There are currently 1260 clinical trials in Columbus, Ohio looking for participants to engage in research studies. Trials are conducted at various facilities, including Nationwide Children's Hospital, Ohio State University Comprehensive Cancer Center, Ohio State University and The Ohio State University. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Magnetic Resonance Elastography as a Method to Estimate Stiffness of Soft Tissues
NCT01757730
Recruiting
Magnetic resonance elastography is a novel non-invasive MRI technique to obtain stiffness of soft tissues such as liver, heart, kidneys, etc. In this imaging technique a person is laid in an MR scanner and a paddle (plastic drum) is put on the area of interest to send sound vibration via a speaker placed outside the scan room which is connecting plastic drum via a plastic tube. These vibrations are scanned using MRI to estimate the stiffness of soft tissues such as liver, heart, kidneys, breast... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/23/2023
Locations: The Ohio State University Wexner Medical Center, Columbus, Ohio
Conditions: Heart Failure, Liver Fibrosis, Cardiac Transplant Rejection, Aortic Aneurysms
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Cognitive Status After Removal of Skull Base Meningioma
NCT04635657
Recruiting
The purpose of this prospectively enrolling trial is to assess long-term cognitive outcomes of patients undergoing surgery for resection of a meningioma associated with the frontal and temporal lobes.
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
10/22/2023
Locations: Ohio State University Wexner Medical Center, Columbus, Ohio
Conditions: Meningioma, Skull Base Meningioma, Frontal Meningioma, Temporal Meningioma, Cognitive Impairment, Cognitive Decline, Post-Surgical Cognition
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Long-Term Longitudinal QoL in Patients Undergoing EEA
NCT04087902
Recruiting
This is a prospective longitudinal study to access postoperative 2-year quality of life in patients who undergo endonasal endoscopic approach surgeries of the skull base.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/22/2023
Locations: Ohio State University, Columbus, Ohio
Conditions: Pituitary Tumor, Meningioma, Rathke Cleft Cysts, Chordoma, Chondrosarcoma, Craniopharyngioma, Encephalocele, Esthesioneuroblastoma
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FSHD Molecular Characterization
NCT06096441
Recruiting
To characterize the clinical and molecular phenotype of FSHD.
Gender:
ALL
Ages:
13 years and above
Trial Updated:
10/20/2023
Locations: The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio
Conditions: Facio-Scapulo-Humeral Dystrophy
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EASE: The Materna Prep Pivotal Study
NCT03973281
Recruiting
This study is designed to evaluate the safety and effectiveness of the Materna Prep Device in reducing pelvic muscle injuries during vaginal delivery. Subjects are randomized to Materna Prep Device or Standard of Care without use of the Materna Prep Device Intervention with the Materna Prep Device is expected to be a one-time use of approximately 30-90 minutes during the 1st stage of labor. Subject participation in the study is targeted to be 12 months from the time of the use of the device d... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
10/17/2023
Locations: The Ohio State University Wexner Medical Center, Columbus, Ohio
Conditions: Vaginal Delivery, Pelvic Organ Prolapse
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Perivenous Dexamethasone Therapy: Examining Reduction of Inflammation After Thrombus Removal to Yield Benefit in Subacute and Chronic Iliofemoral DVT
NCT04858776
Recruiting
This is a study of a medical procedure that utilizes a commercially available catheter (the Bullfrog® Micro-Infusion Device) to locally deliver a commercially available anti-inflammatory drug (dexamethasone sodium phosphate injection) around the deep veins after DVT recanalization, where DVT symptoms were present for at least 14 days and no more than 60 days prior to recanalization. The goal of the study is to see if local anti-inflammation helps prevent re-thrombosis of the blood vessel and imp... Read More
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
10/17/2023
Locations: OhioHealth Research Institute, Columbus, Ohio
Conditions: Iliofemoral; Thrombosis
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Identification of Novel Markers of Human Lung Disease
NCT02369575
Recruiting
The purpose of this study is to investigate new therapies for advanced lung disease.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/11/2023
Locations: Davis Heart and Lung Research Institute, Columbus, Ohio
Conditions: Lung Diseases, Interstitial
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Bronchoscopy in Determining the Effect of E-Cigarette Smoking on Biomarkers in the Lungs
NCT03691350
Recruiting
This trial studies biomarkers obtained by bronchoscopy (bronchoalveolar lavage and lung brushings) to determine the effect of smoking e-cigarettes on the lungs. Studying samples of lung cells from participants who smoke e-cigarettes may help doctors learn more about changes that occur in deoxyribonucleic acid and identify biomarkers related to cancer.
Gender:
ALL
Ages:
Between 21 years and 52 years
Trial Updated:
10/07/2023
Locations: Ohio State University Comprehensive Cancer Center, Columbus, Ohio
Conditions: Cigarette Smoker, Current Every Day Smoker
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Treatment of Metastatic Soft Tissue Sarcoma (STS) Patients (FIBROSARC USA)
NCT03420014
Recruiting
The present study is an open-label, randomized, controlled, two-arm multi-center study of the efficacy of L19TNF treatment in combination with doxorubicin versus doxorubicin alone in metastatic leiomyosarcoma patients.
Gender:
ALL
Ages:
Between 16 years and 100 years
Trial Updated:
10/06/2023
Locations: Ohio State University Comprehensive Cancer Center, Columbus, Ohio
Conditions: Leiomyosarcoma
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CAN-Stim Compared to SNS in Treatment of Urinary Urgency Incontinence With Wireless Neuromodulation Technology
NCT02577302
Recruiting
This is a prospective, randomized, controlled, multi-center, study in which 150 evaluable subjects will be randomized 1:1 to receive either a Protect CAN-Stim or SNS InterStim® system. Subjects from both groups will immediately start with therapy. The primary endpoint is a ≥ 50% reduction in number of incontinence episodes associated with urgency at the 3-month visit, with additional measurements assessed at 14 days, 1, 6, 9 and 12-months.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/03/2023
Locations: Integrated Pain Specialists, Columbus, Ohio
Conditions: Urinary Incontinence, Urge
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Fecal Transplant for Pediatric Patients Who Have Recurrent C-diff Infection
NCT02134392
Recruiting
C-diff infection often causes belly pain and diarrhea and can be very hard to treat with medicine. One of the possible reasons that C-diff infection is hard to treat is because there is too much "bad" bacteria in the colon. Investigators believe that putting more "good" bacteria into the colon will help fight the "bad" bacteria. We do this by doing a fecal (poop) transplant. Fecal transplant has been done at other hospitals, but not at Nationwide Children's Hospital. Since our Investigators hav... Read More
Gender:
ALL
Ages:
Between 2 years and 21 years
Trial Updated:
09/28/2023
Locations: GI Division, Nationwide Children's Hospital, Columbus, Ohio
Conditions: Clostridium Difficile
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Phase 2a Multiple Ascending Dose Study in Hospitalized Patients With Pneumonia.
NCT05123755
Recruiting
A Phase 2a, randomized, double-blind, placebo-controlled, multiple ascending dose study in patients who are hospitalized with presumed pneumonia requiring supplemental oxygen therapy. The purpose of this study is to examine the safety, tolerability and efficacy of AV-001 Injection administration daily to the earlier of day 28 or EOT (day prior to hospital discharge). A total of 120 eligible patients (20 patients in each of cohort 1, 2 and 3 and 60 patients in cohort 4) will be recruited from up... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/27/2023
Locations: The Ohio State University, Columbus, Ohio
Conditions: Acute Respiratory Distress Syndrome, COVID-19 Acute Respiratory Distress Syndrome, Viral or Bacterial Infections, Pneumonia, Pneumonia, Viral, Respiratory Infection
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