There are currently 1264 clinical trials in Columbus, Ohio looking for participants to engage in research studies. Trials are conducted at various facilities, including Nationwide Children's Hospital, Ohio State University Comprehensive Cancer Center, Ohio State University and The Ohio State University. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Study to Evaluate the Safety and Tolerability of Single-Dose Intravenous (IV) Oritavancin
NCT05599295
Recruiting
This protocol describes a randomized, open-label study to evaluate the safety and tolerability of single-dose intravenous (IV) oritavancin diphosphate (oritavancin) versus standard of care (SoC) antibiotics for the treatment of pediatric subjects with acute bacterial skin and skin structure infections (ABSSSIs). This study involves two oritavancin products, ORBACTIV® and KIMYRSATM. Oritavancin is the active drug substance in both ORBACTIV and KIMYRSA. This study protocol distinguishes the diffe... Read More
Gender:
ALL
Ages:
Between 3 months and 17 years
Trial Updated:
07/25/2024
Locations: Nationwide Children's Hospital, Columbus, Ohio
Conditions: Acute Bacterial Skin and Skin Structure Infection
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ABTECT-1 - ABX464 Treatment Evaluation for Ulcerative Colitis Therapy -1
NCT05507203
Recruiting
This is a multicenter, randomized, placebo controlled study to evaluate the efficacy and safety of ABX464 given at 25 or 50 mg QD in inducing clinical remission in subjects with moderately to severely active ulcerative colitis who have inadequate response, no response, a loss of response, or an intolerance to either conventional therapies \[corticosteroids, immunosuppressant (i.e. azathioprine, 6-mercaptopurine, methotrexate)\] and/or advanced therapies \[biologics (TNF inhibitors, anti-integrin... Read More
Gender:
ALL
Ages:
16 years and above
Trial Updated:
07/25/2024
Locations: Wexner Medical Center, Columbus, Ohio
Conditions: Ulcerative Colitis
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Posterior Tibial Nerve Stimulation for Children With Pelvic Floor Dyssynergia
NCT06528470
Recruiting
The overall objective of this study is to determine the effect of posterior tibial nerve stimulation (PTNS) on children with constipation due to pelvic floor dyssynergia. Our main hypothesis is that PTNS effectively treats children with constipation secondary to pelvic floor dyssynergia through modulation of anorectal function. We will perform a single-center, randomized controlled pilot study comparing PTNS to sham stimulation in children with constipation secondary to pelvic floor dyssynergia.
Gender:
ALL
Ages:
Between 8 years and 18 years
Trial Updated:
07/25/2024
Locations: Nationwide Children's Hospital, Columbus, Ohio
Conditions: Constipation, Fecal Incontinence in Children, Pelvic Floor Dyssynergia
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Baclofen for Children With Rumination Syndrome
NCT05975684
Recruiting
The goal of this clinical trial is to learn about baclofen in pediatric patients with rumination syndrome. The main question it aims to answer is whether baclofen is effective in treating children with rumination syndrome. Participants will be asked to take baclofen or placebo for 4 weeks and fill out surveys regarding symptoms.
Gender:
ALL
Ages:
Between 4 years and 18 years
Trial Updated:
07/25/2024
Locations: Nationwide Children's Hospital, Columbus, Ohio
Conditions: Rumination Syndrome
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EV Based Platform for Monitoring Therapeutics Response During Pregnancy (ARISE)
NCT06249178
Recruiting
The goal of this prospective observational cohort study of pregnant people at-risk of preeclampsia receiving aspirin as part of clinical care or a planned randomized controlled trial of 81mg vs. 162mg of aspirin is to generate proteomic data to show a distinct maternal and fetal Extracellular Vesicle (EV) proteome profile with aspirin treatment, and develop and validate a multi-marker panel for the monitoring of placental function in people at-risk of Preeclampsia and in response to aspirin trea... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
07/24/2024
Locations: The Ohio State University Wexner Medical Center OB/GYN Maternal and Fetal Medicine, Columbus, Ohio
Conditions: Preeclampsia
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Dose Escalation/ Expansion Study of CA-4948 as Monotherapy in Patients With Acute Myelogenous Leukemia (AML) or Myelodysplastic Syndrome (MDS)
NCT04278768
Recruiting
This is a multicenter, open-label, Phase 1/2a dose escalation and expansion study of orally administered emavusertib (CA-4948) monotherapy in adult patients with AML or higher- risk Myelodysplastic Syndrome (hrMDS). Patients enrolling in the Phase 1 dose escalation of the study must meet one of the following criteria prior to consenting to the study: * Relapse/refractory (R/R) AML with FMS-like tyrosine kinase-3 (FLT3) mutations who have been previously treated with a FLT3 inhibitor * R/R AML... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/24/2024
Locations: The Ohio State University Wexner Medical Center - James Cancer Hospital, Columbus, Ohio
Conditions: Acute Myelogenous Leukemia, Myelodysplastic Syndrome
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A Retrospective Chart Review Study of Patients With Chronic Lung Allograft Dysfunction-Bronchiolitis Obliterans Syndrome (CLAD-BOS) Post Lung Transplantation
NCT06503770
Recruiting
The aim of this study is to describe the forced expiratory volume in 1 second (FEV1) decline and natural disease evolution in patients affected by CLAD-BOS after lung transplantation and receiving an immunosuppressive therapy as standard of care.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/18/2024
Locations: Baylor Scott and White Health Advanced Lung Disease Specialists, Columbus, Ohio
Conditions: Bronchiolitis Obliterans Syndrome Due to and After Lung Transplantation (Disorder)
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Spinal Cord Stimulation and Small Fiber Peripheral Neuropathy
NCT06287736
Recruiting
This is a prospective randomized control trial. Participants enrolled into the study will be randomized into one of three groups, two of which are treatment groups and the third is a control group. A time course of measurements before and after spinal cord stimulation (SCS) treatment (where applicable) will assess pain, DPN severity, small fiber nerve activity, and metabolic health markers.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/17/2024
Locations: The Ohio State University Wexner Medical Center, Columbus, Ohio
Conditions: Diabetic Peripheral Neuropathy
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Using Ultrasound Elastography to Predict Development of Hepatic Sinusoidal Obstruction Syndrome
NCT03865589
Recruiting
To perform an receiver operating characteristic (ROC) analysis, define a threshold and quantify the sensitivity and specificity of US SWE for risk stratification of patients into three categories as defined by the European Bone Marrow Transplant (EBMT) adult and pediatric criteria: no sinusoidal obstruction syndrome (SOS), mild to moderate SOS, and severe to very severe SOS. Secondarily, the investigators would also like to quantify the temporal relationship between US SWE changes and SOS diagno... Read More
Gender:
ALL
Ages:
Between 1 month and 99 years
Trial Updated:
07/16/2024
Locations: Nationwide Children's Hospital, Columbus, Ohio
Conditions: Bone Marrow Transplant Complications, Sinusoidal Obstruction Syndrome, Veno Occlusive Disease, Hepatic, Stem Cell Transplant Complications
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Autologous Platelet-Rich Plasma Therapy in the Treatment of Pyoderma Gangrenosum
NCT05984654
Recruiting
Pyoderma gangrenosum (PG) is a chronic inflammatory condition with severe painful ulcers. We hypothesize that Platelet-rich plasma(PRP) therapy derived from patient's own blood has a high concentration of endogenous growth factors, which will activate the wound-healing cascade stimulating formation of new blood vessels and collagen in PG ulcers.The goal of this study is to evaluate the efficacy and safety of autologous Platelet rich Plasma(PRP) therapy for the treatment of chronic Pyoderma Gangr... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/16/2024
Locations: The Ohio State University Wexner Medical Center, Columbus, Ohio
Conditions: Pyoderma Gangrenosum
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Feasibility Study - Filter Ventilation
NCT04514471
Recruiting
This open label, between-subject, randomized multi-center pilot study will assess the feasibility of conducting a study remotely with telehealth visits to assess the effect of cigarettes with minimal filter ventilation vs. moderate filter ventilation on smoking behavior and biomarkers of tobacco toxicant exposure. Subjective measures, alveolar carbon monoxide, blood pressure and cigarettes per a day will be collected remotely. Biological samples will be collected at home and mailed to the study... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
07/15/2024
Locations: The Ohio State University Comprehensive Cancer Center, Columbus, Ohio
Conditions: Tobacco Use
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Psychologically Informed Education Intervention for Adolescents With Atraumatic Lower-Extremity Injuries
NCT05701618
Recruiting
This is a randomized prospective study assessing the impact of psychosocial factors on pain and physical performance among adolescents with leg pain. A set of psychosocial surveys assessing activity-related fear, stress, anxiety and depression will be completed by the participants. Participants will then complete self-report questionnaires assessing pain, quality of life and functional ability followed by an assessment of physical activity levels assessed with a wearable activity monitor;. Parti... Read More
Gender:
ALL
Ages:
Between 12 years and 18 years
Trial Updated:
07/15/2024
Locations: Nationwide Children's Hospital Sports and Ortho Physical Therapy, Columbus, Ohio
Conditions: Leg Injury
Register for Updates