There are currently 1259 clinical trials in Columbus, Ohio looking for participants to engage in research studies. Trials are conducted at various facilities, including Nationwide Children's Hospital, Ohio State University Comprehensive Cancer Center, Ohio State University and The Ohio State University. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Feasibility and Acceptability of Incorporating Smartwatches Into an Exercise is Medicine Program in Older Individuals
NCT06287255
Recruiting
The effects of exercise on prevention and improved control of chronic diseases, reduced mortality, and improved quality of life are well established. Exercise has been shown to prevent heart disease, stroke, type 2 diabetes, depression, and certain types of cancers. In addition to prevention, physical activity is included in the standard or care for many chronic diseases and used in treatment. For example, the American Diabetes Association has identified positive health behaviors like physical a... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
08/01/2024
Locations: The Ohio State University, Columbus, Ohio
Conditions: Physical Inactivity, Obesity
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Evaluation of Canakinumab in High-Risk Former-Smokers
NCT06038526
Recruiting
This phase II trial tests the impact of canakinumab on biologic samples (buccal, nasal, and blood) from former smokers with increased risk of cancer. Canakinumab blocks the activity of a protein called interleukin-1 beta (IL-1b), an agent of the inflammatory system and is used for the treatment of different non-cancer diseases (like auto-inflammatory diseases). Giving canakinumab may block the inflammatory system and could have positive effects to reduce cancer growth.
Gender:
ALL
Ages:
Between 55 years and 73 years
Trial Updated:
07/27/2024
Locations: Ohio State University Comprehensive Cancer Center, Columbus, Ohio
Conditions: Cigarette Smoking-Related Carcinoma, Lung Carcinoma
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Improvement of PPROM Management With Prophylactic Antimicrobial Therapy (iPROMPT)
NCT06396078
Recruiting
To conduct an unblinded pragmatic randomized controlled trial (pRCT) "Improvement of PPROM Management with Prophylactic Antimicrobial Therapy (iPROMPT)" of a seven-day course of ceftriaxone, clarithromycin, and metronidazole versus the current standard of care of a seven-day course of ampicillin/amoxicillin and azithromycin or erythromycin to prolong pregnancy and decrease adverse perinatal outcomes among hospitalized pregnant individuals undergoing expectant management of PPROM \<34 weeks.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
07/26/2024
Locations: The Ohio State University Wexner Medical Center OB/GYN Maternal and Fetal Medicine, Columbus, Ohio
Conditions: Preterm Premature Rupture of Membrane, Pregnancy, High Risk, Preterm Birth
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Registry of Avance® Nerve Graft's Utilization and Recovery Outcomes Post Peripheral Nerve Reconstruction
NCT01526681
Recruiting
This study is a registry of general use of Avance Nerve Graft and is intended to evaluate the uses, response rates, and safety of Avance Nerve Graft in the real-life clinical setting. Optional addendums 1 and 2 included in the protocol are intended to establish comparative groups and focused subgroups within the registry.
Gender:
ALL
Ages:
All
Trial Updated:
07/25/2024
Locations: RANGER: Ohio State University Medical Center, Columbus, Ohio +1 locations
Conditions: Peripheral Nerve Injuries
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Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis
NCT04102371
Recruiting
The objectives of this multicenter pragmatic clinical trial are to compare the effectiveness and relative safety of balanced fluid resuscitation versus 0.9% "normal" saline in children with septic shock, including whether balanced fluid resuscitation can reduce progression of kidney injury.
Gender:
ALL
Ages:
Between 2 months and 17 years
Trial Updated:
07/25/2024
Locations: Nationwide Children's Hospital, Columbus, Ohio
Conditions: Shock, Septic
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ABTECT-1 - ABX464 Treatment Evaluation for Ulcerative Colitis Therapy -1
NCT05507203
Recruiting
This is a multicenter, randomized, placebo controlled study to evaluate the efficacy and safety of ABX464 given at 25 or 50 mg QD in inducing clinical remission in subjects with moderately to severely active ulcerative colitis who have inadequate response, no response, a loss of response, or an intolerance to either conventional therapies \[corticosteroids, immunosuppressant (i.e. azathioprine, 6-mercaptopurine, methotrexate)\] and/or advanced therapies \[biologics (TNF inhibitors, anti-integrin... Read More
Gender:
ALL
Ages:
16 years and above
Trial Updated:
07/25/2024
Locations: Wexner Medical Center, Columbus, Ohio
Conditions: Ulcerative Colitis
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Baclofen for Children With Rumination Syndrome
NCT05975684
Recruiting
The goal of this clinical trial is to learn about baclofen in pediatric patients with rumination syndrome. The main question it aims to answer is whether baclofen is effective in treating children with rumination syndrome. Participants will be asked to take baclofen or placebo for 4 weeks and fill out surveys regarding symptoms.
Gender:
ALL
Ages:
Between 4 years and 18 years
Trial Updated:
07/25/2024
Locations: Nationwide Children's Hospital, Columbus, Ohio
Conditions: Rumination Syndrome
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Posterior Tibial Nerve Stimulation for Children With Pelvic Floor Dyssynergia
NCT06528470
Recruiting
The overall objective of this study is to determine the effect of posterior tibial nerve stimulation (PTNS) on children with constipation due to pelvic floor dyssynergia. Our main hypothesis is that PTNS effectively treats children with constipation secondary to pelvic floor dyssynergia through modulation of anorectal function. We will perform a single-center, randomized controlled pilot study comparing PTNS to sham stimulation in children with constipation secondary to pelvic floor dyssynergia.
Gender:
ALL
Ages:
Between 8 years and 18 years
Trial Updated:
07/25/2024
Locations: Nationwide Children's Hospital, Columbus, Ohio
Conditions: Constipation, Fecal Incontinence in Children, Pelvic Floor Dyssynergia
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Dose Escalation/ Expansion Study of CA-4948 as Monotherapy in Patients With Acute Myelogenous Leukemia (AML) or Myelodysplastic Syndrome (MDS)
NCT04278768
Recruiting
This is a multicenter, open-label, Phase 1/2a dose escalation and expansion study of orally administered emavusertib (CA-4948) monotherapy in adult patients with AML or higher- risk Myelodysplastic Syndrome (hrMDS). Patients enrolling in the Phase 1 dose escalation of the study must meet one of the following criteria prior to consenting to the study: * Relapse/refractory (R/R) AML with FMS-like tyrosine kinase-3 (FLT3) mutations who have been previously treated with a FLT3 inhibitor * R/R AML... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/24/2024
Locations: The Ohio State University Wexner Medical Center - James Cancer Hospital, Columbus, Ohio
Conditions: Acute Myelogenous Leukemia, Myelodysplastic Syndrome
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EV Based Platform for Monitoring Therapeutics Response During Pregnancy (ARISE)
NCT06249178
Recruiting
The goal of this prospective observational cohort study of pregnant people at-risk of preeclampsia receiving aspirin as part of clinical care or a planned randomized controlled trial of 81mg vs. 162mg of aspirin is to generate proteomic data to show a distinct maternal and fetal Extracellular Vesicle (EV) proteome profile with aspirin treatment, and develop and validate a multi-marker panel for the monitoring of placental function in people at-risk of Preeclampsia and in response to aspirin trea... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
07/24/2024
Locations: The Ohio State University Wexner Medical Center OB/GYN Maternal and Fetal Medicine, Columbus, Ohio
Conditions: Preeclampsia
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Autologous Platelet-Rich Plasma Therapy in the Treatment of Pyoderma Gangrenosum
NCT05984654
Recruiting
Pyoderma gangrenosum (PG) is a chronic inflammatory condition with severe painful ulcers. We hypothesize that Platelet-rich plasma(PRP) therapy derived from patient's own blood has a high concentration of endogenous growth factors, which will activate the wound-healing cascade stimulating formation of new blood vessels and collagen in PG ulcers.The goal of this study is to evaluate the efficacy and safety of autologous Platelet rich Plasma(PRP) therapy for the treatment of chronic Pyoderma Gangr... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/16/2024
Locations: The Ohio State University Wexner Medical Center, Columbus, Ohio
Conditions: Pyoderma Gangrenosum
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Psychologically Informed Education Intervention for Adolescents With Atraumatic Lower-Extremity Injuries
NCT05701618
Recruiting
This is a randomized prospective study assessing the impact of psychosocial factors on pain and physical performance among adolescents with leg pain. A set of psychosocial surveys assessing activity-related fear, stress, anxiety and depression will be completed by the participants. Participants will then complete self-report questionnaires assessing pain, quality of life and functional ability followed by an assessment of physical activity levels assessed with a wearable activity monitor;. Parti... Read More
Gender:
ALL
Ages:
Between 12 years and 18 years
Trial Updated:
07/15/2024
Locations: Nationwide Children's Hospital Sports and Ortho Physical Therapy, Columbus, Ohio
Conditions: Leg Injury
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