There are currently 1282 clinical trials in Pittsburgh, Pennsylvania looking for participants to engage in research studies. Trials are conducted at various facilities, including University of Pittsburgh, University of Pittsburgh Medical Center, Children's Hospital of Pittsburgh UPMC and Allegheny General Hospital. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
A Study of Therapeutic Iobenguane (131-I) and Vorinostat for Recurrent or Progressive High-Risk Neuroblastoma Subjects
NCT03561259
Recruiting
The purpose of this study is to evaluate the efficacy and safety of 131I-MIBG in combination with Vorinostat in patients with Recurrent or Progressive neuroblastoma
Gender:
All
Ages:
1 year and above
Trial Updated:
02/15/2023
Locations: Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania +1 locations
Conditions: Neuroblastoma, Neuroectodermal Tumors, Neoplasms
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Medtronic Signia SDR Product Surveillance Registry
NCT05095935
Recruiting
The purpose of the registry is to confirm the safety and performance of the Signia™ Small Diameter Reload (SDR) when used in surgical procedures in a real-world setting in patients receiving surgery for indicated thoracic, abdominal, and pediatric applications, intraoperatively.
Gender:
All
Ages:
All
Trial Updated:
02/08/2023
Locations: UPMC Falk Clinic, Pittsburgh, Pennsylvania
Conditions: Minimally Invasive Surgical Procedures, Surgical Procedures, Operative
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ACDF Using Structural Allograft vs. Tritanium C
NCT04388332
Recruiting
This is an observational, descriptive, prospective and retrospective data collection study. The purpose of this study is to observe radiographic outcomes of patients who will undergo anterior cervical discectomy and fusion (ACDF) utilizing Tritanium C (Stryker Spine). The rate of fusion success and adverse events will be compared retrospectively to patients who underwent instrumented ACDF utilizing structural allograft bone with plates.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
02/07/2023
Locations: Allegheny Health Network, Pittsburgh, Pennsylvania
Conditions: Degenerative Disc Disease
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Vaginal Estrogen and Pelvic Floor Physical Therapy in Women With Symptomatic Mild Prolapse
NCT01648751
Recruiting
This is a randomized controlled trial in which women with symptomatic mild pelvic organ prolapse undergoing Pelvic Floor Physical Therapy (PFPT) receive vaginal estrogen versus placebo to see if a combined approach to treatment leads to improvement in clinical outcomes. The investigators predict that PFPT in combination with vaginal estrogen will lead to decreased pelvic floor symptoms and improved anatomical support corroborated by biomarker data.
Gender:
Female
Ages:
Between 40 years and 80 years
Trial Updated:
02/07/2023
Locations: Magee-Womens Hospital, University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Pelvic Organ Prolapse
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Targeted Reversal of Inflammation in Pediatric Sepsis-induced MODS
NCT05267821
Recruiting
The TRIPS study is a prospective, multi-center, double-blind, adaptively randomized, placebo-controlled clinical trial of the drug anakinra for reversal of moderate to severe hyperinflammation in children with sepsis-induced multiple organ dysfunction syndrome (MODS).
Gender:
All
Ages:
Between 1 day and 17 years
Trial Updated:
02/07/2023
Locations: Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome (MODS)
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GM-CSF for Reversal of Immunoparalysis in Pediatric Sepsis-induced MODS
NCT05266001
Recruiting
The GRACE-2 study is a prospective, multi-center, double-blind, randomized controlled trial of the drug GM-CSF vs placebo in children with sepsis-induced multiple organ dysfunction syndrome (MODS) who have immunoparalysis with mild to moderate inflammation.
Gender:
All
Ages:
Between 1 day and 17 years
Trial Updated:
02/07/2023
Locations: Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome
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Apixaban for the Acute Treatment of Venous Thromboembolism in Children
NCT02464969
Recruiting
To assess the safety and descriptive efficacy of apixaban in pediatric subjects requiring anticoagulation for the treatment of a VTE.
Gender:
All
Ages:
Between 0 days and 17 years
Trial Updated:
02/06/2023
Locations: UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Venous Thromboembolism
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The PROMISE Study: Duavee in Women With DCIS
NCT02694809
Recruiting
The main purpose of this study is to determine if taking the study drug, conjugated estrogens/bazedoxifene (Duavee®) causes any changes in the proliferation markers within the breast tissue of the study subjects. The study drug is approved by the US Food and Drug Administration in healthy postmenopausal women to treat certain symptoms of menopause such as hot flashes. Since it is not approved in women with DCIS, its use in this study is experimental. This study will also look at whether taking t... Read More
Gender:
Female
Ages:
Between 18 years and 79 years
Trial Updated:
02/06/2023
Locations: University of Pittsburg/ Magee-Womens Hospital, Pittsburgh, Pennsylvania
Conditions: Ductal Breast Carcinoma In Situ, Postmenopausal
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CORRECT Study of Minimal Residual Disease Detection in Colorectal Cancer
NCT05210283
Recruiting
The CORRECT - MRD II study will prospectively enroll patients who have undergone complete surgical resection for stage II or III colorectal cancer. Patients will be followed for a minimum of 3 years and up to 5 years for recurrence.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/01/2023
Locations: UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania
Conditions: Colorectal Cancer
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Sustaining Remission From PTSD Using Tuned Vibroacoustic Stimulation (TVS) Following MDMA-Assisted Psychotherapy
NCT05274230
Recruiting
The purpose of this research is to examine a wearable device called Apollo that emits gentle vibrations found to benefit mood, energy, and focus. We want to understand how it affects outcomes related to MDMA-assisted psychotherapy for PTSD including depression, anxiety and emotion regulation. This study will test whether regular use of the Apollo wearable improves rates of sustained symptom remission in PTSD following MDMA-assisted psychotherapy over the course of two years
Gender:
All
Ages:
18 years and above
Trial Updated:
01/31/2023
Locations: Apollo Neuroscience, Inc., Pittsburgh, Pennsylvania
Conditions: Stress Disorders, Post-Traumatic
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A Study of ZN-c3 in Participants With Solid Tumors
NCT04158336
Recruiting
This is a Phase 1 open-label, multicenter study of ZN-c3 monotherapy which consists of Dose Escalation, a Food Effect Cohort, and Dose Expansion.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/30/2023
Locations: Site 0179, Pittsburgh, Pennsylvania
Conditions: Solid Tumor
Register for Updates
Study of Pembrolizumab Combined With Decitabine and Pralatrexate in PTCL and CTCL
NCT03240211
Recruiting
This is an international, multicenter, multi-arm, phase Ib, model-based dose-escalation study. The primary objectives of the study in each arm is to determine the maximum tolerated dose (MTD), recommended phase 2 dose (RP2D), dose limiting toxicities (DLTs) and to evaluate the clinical efficacy at the MTD of various combinations of pembrolizumab, pralatrexate and decitabine.
Gender:
All
Ages:
Between 18 years and 90 years
Trial Updated:
01/05/2023
Locations: Allegheny Health Network, Pittsburgh, Pennsylvania
Conditions: PTCL, CTCL
Register for Updates