There are currently 1248 clinical trials in Nashville, Tennessee looking for participants to engage in research studies. Trials are conducted at various facilities, including Vanderbilt University Medical Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University and Sarah Cannon Research Institute. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Image-Based, In-Vivo Assessment of Tumor Hypoxia to Guide Hypoxia-Driven Adaptive Radiation Therapy
NCT05996432
Recruiting
This study will apply novel MRI approaches with established sensitivity to tissue oxygen consumption and perfusion to predict hypoxia-associated radiation resistance, manifested as tumor recurrence and progression post-treatment.
Gender:
All
Ages:
18 years and above
Trial Updated:
08/10/2023
Locations: Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee
Conditions: Head and Neck Squamous Cell Carcinoma, Brain Metastases
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Physiological Brain Atlas Development
NCT00575081
Recruiting
The NIH grant has funded the development of a physiological brain atlas registry that will allow us to significantly improve the data collectioin and use of physiological data into a normalized brain volume. This initially was used to improve DBS implants for Parkinson's Disease, Dystonia, Essential Tremor, and OCD, but now includes data acquired during all stereotactic brain procedures.
Gender:
All
Ages:
Between 6 years and 90 years
Trial Updated:
08/09/2023
Locations: Vanderbilt Univeristy, Nashville, Tennessee
Conditions: Parkinson's Disease, Obsessive Compulsive Disorder, Dystonia, Essential Tremor, Epilepsy
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Biomarker-Driven Radiation Therapy Dose Reduction After Transoral Robotic Surgery for the Treatment of HPV-Positive Oropharyngeal Cancer
NCT05387915
Recruiting
This phase II trial tests whether reduced dose radiation therapy after transoral robotic surgery works in treating patients with human papillomavirus (HPV)-positive oropharyngeal cancer. HPV positive oropharyngeal cancer has a better prognosis than oropharyngeal cancer not caused by HPV. A standard of care treatment for HPV positive oropharyngeal cancer is transoral robotic surgery followed by radiation therapy. However, this treatment is associated with many long-term side effects including dif... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
08/08/2023
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Oropharyngeal HPV-Positive Squamous Cell Carcinoma
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Cancer Driving Mutations in Endometriosis Lesions and Development of Progesterone Resistance
NCT03756480
Recruiting
This study will test the hypothesis that the molecular changes present in ectopic endometriosis lesions correlate with progesterone-resistant disease (using the criteria defined in this study) and are present in matched eutopic endometrium.
Gender:
Female
Ages:
Between 18 years and 45 years
Trial Updated:
08/07/2023
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Endometriosis, Endometrial Diseases
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Collecting and Storing Tissue Samples From Women With or Without Breast Cancer
NCT00899301
Recruiting
RATIONALE: Collecting and storing samples of tissue, blood, and urine from patients with or without breast cancer to study in the laboratory may help the study of cancer. PURPOSE: This research study is collecting and storing tissue samples from women with or without breast cancer.
Gender:
Female
Ages:
18 years and above
Trial Updated:
08/01/2023
Locations: Vanderbilt-Ingram Cancer Center, Nashville, Tennessee
Conditions: Breast Cancer
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BRAVE Strategy - Breast Cancer Risk Assessment -achieVing Equity
NCT05051631
Recruiting
The central goal of this study is to test strategies to implement evidence-based breast cancer risk assessment in healthcare clinics in Tennessee. The BRAVE Strategy (Breast cancer Risk Assessment - achieVing Equity) study aims to assess the feasibility, reach, acceptability, and appropriateness of select customized strategies to increase uptake of breast cancer risk assessment. The investigators will achieve these aims through a conducting a stepped-wedge trial conducted in 10 healthcare clinic... Read More
Gender:
Female
Ages:
Between 25 years and 49 years
Trial Updated:
07/28/2023
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Breast Cancer
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CoQ10 and Exercise for Mitochondrial Dysfunction in Advance Kidney Disease
NCT05422534
Recruiting
Frailty and sarcopenia are modifiable risk factors for morbidity and mortality in patients with ESRD. Exercise is the recommended intervention to prevent frailty and sarcopenia, however, many clinical trials have shown limited clinical improvement in muscle mass and physical function. We propose that mitochondrial dysfunction is one of the deterrents to the effectiveness of the exercise. We plan to evaluate the additive effect of HIIT and CoQ10, a mitochondrial-targeted therapy, on mitochondrial... Read More
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
07/27/2023
Locations: Vanderbilt University Medical Center-GCRC, Nashville, Tennessee
Conditions: End Stage Renal Disease
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Trial of Parkinson's And Zoledronic Acid
NCT03924414
Recruiting
This home-based study is a randomized (1:1) placebo-controlled trial of a single infusion of zoledronic acid-5 mg (ZA) for the prevention of fractures in men and women aged 60 years and older with Parkinson's disease and parkinsonism with at least 2 years of follow-up. A total of 3500 participants will be enrolled and randomized in the United States. Participants, follow-up outcome assessors, and study investigators will be blinded to assigned study treatment. This trial is funded by the Nationa... Read More
Gender:
All
Ages:
60 years and above
Trial Updated:
07/24/2023
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Parkinson Disease, Osteoporosis, Parkinsonism, Parkinson's Disease and Parkinsonism, Atypical Parkinsonism, Progressive Supranuclear Palsy, Multiple System Atrophy, Vascular Parkinsonism, Dementia With Lewy Bodies
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Safety and Efficacy of AM712 in Patients With nAMD
NCT05345769
Recruiting
The purpose of this Phase 1 study is comprised of multiple ascending-dose component (Part 1) and high concentration component (Part 2) to evaluate the safety, tolerability, pharmacokinetics, and efficacy of AM712 in patients with neovascular age- related macular degeneration (nAMD).
Gender:
All
Ages:
50 years and above
Trial Updated:
07/24/2023
Locations: Tennessee Retina, PC, Nashville, Tennessee
Conditions: Neovascular Age-related Macular Degeneration
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Neurophysiology Biomarkers of Cognitive Impairment Associated With Deep Brain Stimulation
NCT05933681
Recruiting
The study aims to investigate cognitive impairment associated with Deep Brain Stimulation (DBS) in Parkinson's Disease patients, with a focus on identifying neurophysiology biomarkers of DBS associated cognitive changes. Using neurophysiology data recorded during DBS surgeries and post-implantation, the research intends to identify biomarkers in order to optimize electrode placement, enhance programming, and ultimately minimize DBS-related cognitive side effects.
Gender:
All
Ages:
40 years and above
Trial Updated:
07/21/2023
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Parkinson Disease
Register for Updates
Corticostriatal Contributions to Parkinson's Disease Cognitive Impairment
NCT04715984
Recruiting
The goal of this study is to learn more about the brain activity underlying Parkinson's disease cognitive impairment. The investigators will utilize neural recordings from corticostriatal structures performed during deep brain stimulation surgery to measure neural activity underlying nonmotor symptoms of Parkinson's disease.
Gender:
All
Ages:
40 years and above
Trial Updated:
07/21/2023
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Parkinson Disease
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A Study to Evaluate the Safety and Efficacy of NEXAGON® (Lufepirsen Ophthalmic Gel) in Subjects With PCED
NCT05966493
Recruiting
This study is to evaluate the safety and efficacy of NEXAGON® (lufepirsen ophthalmic gel) (NEXAGON) in subjects with persistent corneal epithelial defects (PCED). The objectives of the study are to evaluate the safety and efficacy of NEXAGON in this population.
Gender:
All
Ages:
2 years and above
Trial Updated:
07/21/2023
Locations: Principal Investigator, Nashville, Tennessee
Conditions: Persistent Corneal Epithelial Defect
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