There are currently 1244 clinical trials in Nashville, Tennessee looking for participants to engage in research studies. Trials are conducted at various facilities, including Vanderbilt University Medical Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University and Sarah Cannon Research Institute. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Epidemiology of Silent and Overt Strokes in Sickle Cell Disease
NCT03376893
Recruiting
Sickle Cell Disease (SCD) is a rare disease occurring in an estimated 100,000 individuals, often poor and underserved, in the US. Silent and overt strokes contribute significantly to morbidity in adults with SCD, resulting in functional impairment, challenges with school and job performance, and premature death. Five NIH-funded randomized controlled trials have identified therapies to prevent silent and overt strokes in children with SCD, including monthly blood transfusion therapy (for preventi... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/30/2024
Locations: Vanderbilt University Medical Center, Nashville, Tennessee +1 locations
Conditions: Anemia, Sickle Cell, Sickle Cell Disease, Stroke, Sickle Cell Thalassemia, Sickle Cell-Beta0-Thalassemia
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Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs
NCT04613921
Recruiting
Management of ACLF is mainly supportive. The poor outcomes lead physicians to consider liver transplantation as an option, even if controversial. In sicker recipients, LT results in immediate survival, but poor medium-term survival rates in some studies. The scarcity of deceased donors obliges to maximize LT success. Alternative strategies, as living-donor LT, should be explored. LDLT has impressive results in Eastern centers, but it is restrained in Western countries, due to potential life-thre... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
08/27/2024
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Liver Diseases, Liver Cirrhosis, Acute-On-Chronic Liver Failure, Liver Transplant; Complications
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Study to Assess the Safety and Tolerability of CFT7455 in Relapsed/Refractory Non-Hodgkin's Lymphoma or Multiple Myeloma
NCT04756726
Recruiting
The purpose of this study is to characterize the safety, tolerability, pharmacokinetics, pharmacodynamics, and antitumor activity of oral cemsidomide (also known as CFT7455) administered at different dosages in subjects with Relapsed/Refractory (r/r) Non-Hodgkin's Lymphoma (NHL) or Multiple Myeloma (MM). Cemsidomide may be administered as a single agent and, in MM only, in combination with oral dexamethasone.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/27/2024
Locations: Tennessee Oncology (Sarah Cannon Research Institute), Nashville, Tennessee
Conditions: Multiple Myeloma, Lymphoma, Non-Hodgkin's
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From Opinion to Evidence: Multi-site Evaluation of Custom Dynamic Orthosis Best Practices
NCT06352788
Recruiting
This study is designed to support evidence-based practice and optimal care by evaluating how different configurations of two types of carbon fiber custom dynamic orthoses (CDOs) influences outcomes following traumatic lower extremity injury.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
08/26/2024
Locations: Vanderbilt University - Zelik Lab For Biomechanics & Assistive Technology, Nashville, Tennessee
Conditions: Foot Injury
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The APS Phenotyping Study
NCT06521502
Recruiting
The goal of the observational APS phenotyping study is to better understand risk factors, potential biomarkers, length and severity of illness, and recovery for adults with ARDS, pneumonia, and/ or sepsis. This study will also generate a biobank of specimens collected from these patients that will be available to investigators for future studies of ARDS, sepsis, and/or pneumonia.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/26/2024
Locations: Meharry Medical College, Nashville, Tennessee +1 locations
Conditions: ARDS, Sepsis, Pneumonia
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CBT Enhanced With Social Cognitive Training vs. CBT Only With Depressed Youth
NCT05456035
Recruiting
Depression in youth is a serious public health concern for which more personalized treatments are needed. This randomized controlled trial will test the effect of an intervention aimed at enhancing social cognitive capacities (e.g., ability to take another's perspective), thereby making treatment of depression in youth more efficient and effective. Participants in the R33 (N=82) will be youth between ages 13- through 17-years-old currently experiencing depression. Youth will be randomized to eit... Read More
Gender:
ALL
Ages:
Between 13 years and 17 years
Trial Updated:
08/24/2024
Locations: Judy Garber, Nashville, Tennessee
Conditions: Depression
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Collecting and Storing Tissue Samples From Women With or Without Breast Cancer
NCT00899301
Recruiting
RATIONALE: Collecting and storing samples of tissue, blood, and urine from patients with or without breast cancer to study in the laboratory may help the study of cancer. PURPOSE: This research study is collecting and storing tissue samples from women with or without breast cancer.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
08/23/2024
Locations: Vanderbilt-Ingram Cancer Center, Nashville, Tennessee
Conditions: Breast Cancer
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Cholinergic Mechanisms of Attention in Aging
NCT04756232
Recruiting
This study will use an anticholinergic pharmacological probe to examine attention network function in SCD using EEG. The overall hypothesis is that in older adults with SCD, normal cognitive performance is maintained by compensatory attention network activity, supported by enhanced cholinergic function. The investigators anticipate that SCD will be associated with greater compensatory attention network activity and that disrupting this compensatory process through anticholinergic challenge will... Read More
Gender:
ALL
Ages:
55 years and above
Trial Updated:
08/23/2024
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Subjective Cognitive Decline
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Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study
NCT05548283
Recruiting
The purpose of this study is to look at pulmonary exacerbations in people with cystic fibrosis (CF) that need to be treated with antibiotics given through a tube inserted into a vein (intravenous or IV). A pulmonary exacerbation is a worsening of respiratory symptoms in people with CF that needs medical intervention. Both doctors and CF patients are trying to understand the best way to treat pulmonary exacerbations. This study is trying to answer the following questions about treating a pulmonar... Read More
Gender:
ALL
Ages:
6 years and above
Trial Updated:
08/23/2024
Locations: Vanderbilt Children's Hospital, Nashville, Tennessee
Conditions: Cystic Fibrosis, Cystic Fibrosis Pulmonary Exacerbation
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Stereotactic Radiosurgery for Essential Tremor and Parkinsonian Tremor
NCT01734122
Recruiting
The purpose of this study is to determine the changes in quality of life and degree of tremor for patients with essential tremor or Parkinsonian tremor who are treated by stereotactic radiosurgery (SRS). This is a questionnaire-based study. Please see Detailed Description below for more information.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/22/2024
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Tremor, Essential Tremor, Parkinson Disease, Radiosurgery, Quality of Life
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S1803, Lenalidomide +/- Daratumumab/rHuPh20 as Post-ASCT Maintenance for MM w/MRD to Direct Therapy Duration
NCT04071457
Recruiting
Patients are enrolled to screening (Reg Step 1) prior to or after ASCT but prior to Reg Step 2. Patients are followed until they will begin Maintenance and then registered to Reg Step 2 (first randomization). Patients are randomized between Lenalidomide for 2 years and Lenalidomide + Daratumumab/rHuPH20. After 2 years of Maintenance, MRD is assessed to guide further therapy. MRD-positive patients will continue with the assigned treatment. MRD-negative patients will be further randomized (Reg Ste... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
08/21/2024
Locations: Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee
Conditions: Multiple Myeloma
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Delirium Reduction With Ramelteon
NCT05069428
Recruiting
The overall purpose of this study is to identify a medication that might treat and/or prevent delirium in intensive care unit (ICU). Currently, there is no proven medical therapy for prevention or treatment of delirium. Ramelteon is a medication approved for insomnia. We hypothesize that ramelteon may help regulate the day/night cycle and decrease ICU delirium.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/20/2024
Locations: Centennial Medical Center, Nashville, Tennessee
Conditions: Delirium
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