Ketamine for Postoperative Avoidance of Depressive Symptoms: The K-PASS Feasibility Trial
NCT05233566
Completed
This protocol describes a feasibility trial that will evaluate the feasibility of conducting a full-scale phase 3 trial testing the hypothesis that a postoperative sustained, low-dose ketamine infusion can prevent postoperative depressive symptoms when administered to a targeted population of neurosurgical patients with a history of depression.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/13/2024
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Postoperative Depression
Register for Updates
Ketamine as a Supplement to Local Anesthesia for Minor Procedures
NCT06284473
Recruiting
This trial is a double-blind randomized controlled clinical trial of adults and children (ages 7 to less than 70 years). Patients who present to the ED and who undergo minor bedside procedures that require local anesthesia will be divided into two groups: The first group will be treated with 0.7 mg/kg intranasal ketamine as well as standard local anesthesia for the procedure (treatment cohort). The second group will be treated with a volume-based dose of intranasal saline solution as well as sta... Read More
Gender:
ALL
Ages:
Between 7 years and 70 years
Trial Updated:
03/13/2024
Locations: Loyola University Medical Center, Maywood, Illinois
Conditions: Pain, Procedural, Minor Laceration, Abscess
Register for Updates
Connectivity Changes Associated With Ketamine Assisted Psychotherapy for PTSD
NCT06036511
Withdrawn
The goal of this clinical trial is to learn about the effects of Ketamine Assisted Psychotherapy \[KAP\] on individuals with Post Traumatic Stress Disorder \[PTSD\]. The main questions it aims to answer are: 1. Does KAP improve symptoms of PTSD? 2. What changes in brain network connectivity are seen with KAP?
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/08/2024
Locations: University of New Mexico, Albuquerque, New Mexico
Conditions: PTSD
Register for Updates
Ketamine for OUD and Comorbid Depression (OUDCD)
NCT05051449
Terminated
Methadone is a first-line, evidence-based treatment for opioid use disorder (OUD). Unfortunately, retention and adherence in methadone treatment is a major challenge. OUD patients frequently present with co-morbid depression (OUDCD), a risk factor for poor OUD treatment outcomes, overdose, and suicide. The last two decades have seen an exciting and transformational development in the treatment of depression - ketamine. As a safe, rapid-acting anti-depressant deliverable within the context of met... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/05/2024
Locations: University of Maryland Baltimore, Baltimore, Maryland
Conditions: Depressive Disorder, Opioid Use Disorder
Register for Updates
Ketamine for Post-operative Analgesia in Hemorrhoidectomy
NCT04248205
Recruiting
This is a prospective, randomized study of ketamine versus no ketamine in approximately 100 patients undergoing hemorrhoidectomy for Grade III or IV hemorrhoids. The participants will be blinded to which treatment arm they are assigned, because participants will be under anesthesia when the ketamine is administered. The investigators will know whether the participant receives ketamine or not.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
03/04/2024
Locations: University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Conditions: Hemorrhoids
Register for Updates
Prospective Study of Induction Medications Used in the Trauma RSI
NCT04291521
Not Yet Recruiting
To compare the outcomes of the use of propofol, etomidate, and ketamine as induction agents for adult trauma patients undergoing intubation within 24 hours of admission. The primary goal is to determine the ideal agent that should be used in this patient population for intubations.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/03/2024
Locations: Keck School of Medicine of the University of Southern California, Los Angeles, California
Conditions: Trauma, Rapid Sequence Intubation
Register for Updates
The CHECK Trial: A Comparison of Headache Treatment in the Emergency Department: Compazine Versus Ketamine
NCT02735343
Terminated
Investigators are comparing Ketamine to prochlorperazinecompazine for benign headaches in the ED. Subjects will be randomized into 1 of 2 groups. Group 1 will receive standard treatment of prochlorperazinecompazine 10 mg IV along with diphenhydramine 25 mg IV. Group 2 (research arm) will receive Ketamine 0.3 mg/kg along with ondansetron 4 mg IV. Subjects will be seen at 15, 30, 45, and 60 minutes post-intervention to obtain Heart Rate, Blood Pressure, Headache severity, Nausea severity, Vomiting... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
02/28/2024
Locations: Mike O'Callaghan Federal Medical Center, Nellis Air Force Base, Nevada
Conditions: Headache
Register for Updates
Intravenous Ketamine Plus Neurocognitive Training for Depression
NCT03237286
Completed
This study has two aims: 1) to characterize the effects of intravenous ketamine on neurocognitive markers in depressed patients; 2) to test the efficacy of a synergistic intervention for depression combining intravenous ketamine with neurocognitive training. Three of the primary outcomes listed (fMRI functional connectivity; Implicit Association Test; cognitive flexibility testing) pertain to Aim 1. For Aim 2, one primary clinical outcome (MADRS, a clinician-administered measure of depression se... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
02/23/2024
Locations: Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania
Conditions: Depression
Register for Updates
A Retrospective Effectiveness Trial of Ketamine-Assisted Psychotherapy in Adult Patients Coping With Mental Health
NCT05604794
Completed
Ketamine-Assisted Psychotherapy (KAP) is a relatively new approach for the treatment of mental health issues, which involves the combination of ketamine, a dissociative anaesthetic with psychedelic properties, and psychotherapy to promote emotional wellbeing. In this study, we investigated the effectiveness of KAP in adult patients coping with mental health. We predicted that clients would experience lasting reductions in psychological distress over time, such as depression, anxiety, and post tr... Read More
Gender:
ALL
Ages:
19 years and above
Trial Updated:
02/22/2024
Locations: LA Centre, Los Angeles, California +10 locations
Conditions: Depression, Anxiety, Post Traumatic Stress Disorder
Register for Updates
Effect of Ketamine on Intraoperative Motor Evoked Potentials
NCT06140927
Recruiting
The goal of this clinical trial is to learn about the effect of ketamine on intraoperative motor evoked potentials in adult patients undergoing thoracolumbar spinal fusions. Participants will undergo a standard anesthetic. In addition to the standard anesthetic, the patients will be administered increasing doses of ketamine with motor-evoked potentials being measured at each dose, to assess any impacts.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
02/08/2024
Locations: University of California, San Francisco, San Francisco, California
Conditions: Spine Fusion, Spine Tumor, Spinal Stenosis
Register for Updates
The Effects of Ketamine and Methadone on Postoperative Pain for Laminectomy
NCT02252432
Terminated
The purpose of this research is to determine the pain-reducing effects of ketamine (Ketalar, an FDA-approved drug for anesthesia) and methadone (Dolophine, a long-acting narcotic) after lumbar laminectomy. The investigators would like to evaluate whether intraoperative use of both drugs may be able to provide better control of pain after lumbar surgery.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
02/05/2024
Locations: Cedars Sinai Medical Center, Los Angeles, California
Conditions: Laminectomy
Register for Updates
Facilitating Rapid Naltrexone Initiation
NCT03345173
Active Not Recruiting
The incidence of opioid use disorders (OUDs) has increased to near-epidemic proportions. While maintenance with long-acting opioids such as methadone or buprenorphine represents an effective treatment strategy, it may be unacceptable to many individuals. As a result, long-acting injectable naltrexone (XR-NTX), an antagonist medication that blocks the effects of opioids for at least 4 weeks, is now indicated for relapse prevention following detoxification. This randomized, controlled trial aims t... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
02/01/2024
Locations: New York State Psychiatric Institute, New York, New York
Conditions: Opioid Dependence
Register for Updates