Double Blind Placebo Controlled Study of Outpatient Intravenous Ketamine for the Treatment of CRPS
Completed
Complex Regional Pain Syndrome is a debilitating and extremely difficult to treat condition. There is a large body of evidence demonstrating the therapeutic value of N-methyl-D-aspartate (NMDA)-receptor antagonists in CRPS. The NMDA antagonist ketamine has been shown to be effective in the treatment of CRPS, resulting in complete remission of the disease in some patients. The purpose of this study is to evaluate intravenous outpatient infusion of sub-anesthetic doses of ketamine for the treatmen... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
06/15/2010
Locations: Drexel University College of Medicine Department of Neurology, Philadelphia, Pennsylvania
Conditions: Complex Regional Pain Syndrome
Pilot Study on the Effects of Intravenous Ketamine on Acute Pain Crisis in Patients With Sickle Cell Disease
Terminated
The purpose of this pilot study is to provide a preliminary assessment of the feasibility and efficacy of intravenous ketamine in controlling pain in patients with sickle cell disease (who are admitted to the hospital with severe, acute pain crisis, and who have been resistant to intravenous narcotics).
Gender:
ALL
Ages:
Between 7 years and 18 years
Trial Updated:
03/12/2009
Locations: The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Sickle Cell Disease
Assessing the Effects of a Nasal Corticosteroid on PMI-150 (Intranasal Ketamine)
Completed
To assess the effects of nasal corticosteroid treatment on the rate and extent of intranasal absorption of PMI-150 (intranasal ketamine HCl)
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
04/21/2008
Locations: Not set, Baltimore, Maryland
Conditions: Healthy
Determination of Drug Interactions of Certain Nasal Medications With Intranasal Ketamine
Unknown
This is an open label, single-center study to determine whether certain nasal medication interact with PMI-150 (intranasal ketamine) 30 mg in healthy adult volunteers and in patients with allergic rhinitis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/27/2008
Locations: Javelin Pharmaceuticals, Cambridge, Massachusetts
Conditions: Pharmacokinetics
Absolute Bioavailability and Nasopharyngeal Absorption of Intranasal Ketamine
Completed
This is an open label, single-center study to determine the absolute bioavailability and nasopharyngeal absorption of PMI-150 (intranasal ketamine) 30 mg in healthy adult volunteers.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/09/2008
Locations: Javelin Pharmaceuticals, Cambridge, Massachusetts
Conditions: Healthy
Use of Ketamine Prior to Cardiopulmonary Bypass in Children
Completed
To assess whether the drug ketamine given prior to cardiopulmonary bypass can decrease injury to the cells in the brain.
Gender:
ALL
Ages:
1 year and below
Trial Updated:
11/09/2007
Locations: Arkansas Children's Hospital, Little Rock, Arkansas
Conditions: Ventricular Septal Defect