Effect of Ketamine on Fatigue Following Cancer Therapy
NCT02317341
Terminated
Background: - Fatigue is a common side effect of cancer and its treatment. No medications can treat this fatigue. Researchers want to see if the drug ketamine can improve fatigue after radiation therapy for cancer. They will compare the effects of ketamine on fatigue to midazolam, a sedative with similar effects. Objectives: - To better understand fatigue in people who completed radiation therapy for cancer. To look at the effects of a dose of ketamine on fatigue. Eligibility: - Adults 18 a... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/19/2019
Locations: National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland
Conditions: Cancer, Fatigue, Ketamine
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Intraoperative Low-dose Ketamine Infusion as the Main Analgesic in Burn Patients
NCT03049930
Unknown
The purpose of this study is to determine whether a low-dose ketamine infusion can be used as the main intra-operative analgesic in different burn patients, and thereby reduce the total intra-operative opioid requirement. Secondary objectives are to determine whether this low-dose ketamine infusion will lengthen the amount of time to the first narcotic given in the recovery room or ICU, and whether pain scores for awake patients will be lower post-operatively.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
03/13/2019
Locations: Loyola University Medical Center, Maywood, Illinois
Conditions: Burns
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Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis
NCT02625181
Completed
The purpose of this study is to determine how automated recommendations are best presented to optimize the adherence to guidelines on prophylaxis for nausea and vomiting after surgery.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/05/2019
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Postoperative Nausea and Vomiting
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Post-op Ketamine Study
NCT03865550
Unknown
The purpose of this study is to establish the effect of sub-anesthetic dosing of ketamine with spinal anesthesia during total knee arthroplasty on post-operative pain and narcotic consumption. We hypothesize that sub-anesthetic ketamine will decrease post-operative pain and narcotic consumption and may secondarily lead to shorter lengths of stay, faster rehabilitation, improved postoperative outcomes and patient satisfaction.
Gender:
Not set
Ages:
All
Trial Updated:
03/05/2019
Locations: Rothman Institute, Philadelphia, Pennsylvania
Conditions: Osteo Arthritis Knee
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RCT: Fentanyl Plus Ketamine Versus Fentanyl Alone for Acute Burn Pain
NCT03305055
Terminated
The Ketamine for Acute Pain in Burns study is a randomized, double-blind, parallel group trial (RCT) with active control (usual care) contrasting the efficacy and safety of "Ketamine Plus Opiate-based usual care" (O+K) with the safety and efficacy of the "Current Standard of Care". THe current standard of care is an opiate medication alone, Fentanyl (Usual Care-Opiate (UC-O), dose/timing as per Burn Center protocol).
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
02/18/2019
Locations: Johns Hopkins Burn Center, Baltimore, Maryland
Conditions: Acute Pain, Wound Care, Posttraumatic Stress Disorder
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Alternative Sedation During Bronchoscopy
NCT01158820
Completed
This protocol hopes to determine whether the use of dexmedetomidine-ketamine can reduce the use of standard of care fentanyl-midazolam sedation during bronchoscopy. This may result in less respiratory depression while providing better compliance with the procedure.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
02/05/2019
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Sedation
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Intranasal Ketamine for Pediatric Procedural Sedation: a Feasibility Study
NCT03067974
Terminated
The purpose of this study is to evaluate the feasibility of intranasal ketamine for adequate sedation of children undergoing minor procedures in the Emergency Department. An intranasal dose of 10mg/kg will be used in patients requiring procedural sedation. The investigators hypothesize that this dose of intranasal ketamine will be able to provide adequate sedation and analgesia for the physician to successfully complete the planned diagnostic or therapeutic intervention (Pediatr Emer Care 2012;2... Read More
Gender:
ALL
Ages:
Between 2 years and 7 years
Trial Updated:
01/24/2019
Locations: Banner Univsersity Medical Center Tucson, Tucson, Arizona
Conditions: Failed Moderate Sedation During Procedure, Ketamine Adverse Reaction
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Pre-operative Pregabalin and Ketamine to Prevent Phantom Pain
NCT02311777
Withdrawn
Phantom limb pain (PLP) is as painful sensations located to the missing limb and classified as neuropathic pain. In the United States, an estimated 1.7 million patients have undergone limb amputation, and 60% to 80% of these patients develop PLP (1-2) and it is usually resistant to a wide variety of treatments (1-4). Three factors may contribute to the development of persistent, post-amputation PLP by inducing central sensitization at different times relative to surgery: pre-amputation pain, nox... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/17/2018
Locations: Parkland Health Hospital System, Dallas, Texas +1 locations
Conditions: Phantom Pain
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KETODEX for Emergence Delirium in Children Undergoing Outpatient Strabismus Surgery
NCT03779282
Completed
Strabismus surgery for children is a very common procedure, with a high incidence of emergence delerium in the recovery room. A combination of intravenous ketamine/dexmedetomidine, or ketodex, has been previously shown to reduce emergence delerium in children undergoing adenotonsillectomy. Here, we study its application in strabismus surgery.
Gender:
ALL
Ages:
18 years and below
Trial Updated:
12/17/2018
Locations: Ochsner Main Campus, Jefferson, Louisiana
Conditions: Emergence Delirium, Strabismus
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US-guided SAPB for Rib Fractures in the ED
NCT03619785
Unknown
The purpose of this randomized controlled study is to determine whether the serratus anterior plane block reduces pain more than the usual treatment for rib fractures in the same amount of time.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/14/2018
Locations: Alameda Health System - Highland Hospital, Oakland, California
Conditions: Rib Fractures, Rib Fracture Multiple
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Ketamine for Preventing Depression in Patients Undergoing Treatment for Pancreatic or Head and Neck Cancers
NCT02442739
Withdrawn
The primary purpose of this study is to see if it is safe to give patients with pancreatic or head and neck cancer a low dose of the FDA approved anesthetic drug ketamine at the same time they receive radiation and/or chemotherapy for their cancer treatment to prevent depression and its effects. Researchers would also like to see if giving ketamine at the same time as cancer treatment is practical and reasonably acceptable to the patient. New onset depression is highly frequent in those with he... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/02/2018
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Head and Neck Cancer, Pancreatic Cancer, Depression
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Study of Oral Ketamine Versus Placebo for Treating Depression in Patients Undergoing Treatment for Cancer
NCT02836288
Completed
The primary purpose of this study is to see if it is safe to give patients with cancer a low dose of the FDA approved anesthetic drug ketamine at the same time they receive radiation, chemotherapy, and/or surgery for their cancer treatment to treat depression and its effects. Researchers would also like to see if giving ketamine at the same time as cancer treatment is practical and reasonably acceptable to the patient. Depression has many negative consequences for outcomes in those with cancer.... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/02/2018
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Cancer, Depression
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