Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery
NCT02958566
Unknown
The General Objective of this study is to investigate the cost and efficacy of treating patients undergoing colorectal surgical resections with an opioid limited pain control regimen as part of an Enhanced Recovery After Surgery (ERAS) Protocol. This group will be compared to a traditional opioid based pain control regimen.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/16/2017
Locations: Uicomp, Peoria, Illinois
Conditions: Colon Cancer, Colon Diverticulosis, Colonic Neoplasms, Colonic Diverticulitis, Pain, Postoperative, Ileus, Ileus Paralytic, Ileus; Mechanical, Constipation Drug Induced, Constipation, Rectum Cancer, Rectum Neoplasm
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Intranasal Ketamine In the Treatment of Pediatric Bipolar Disorder
NCT01504659
Terminated
The investigators plan to evaluate the efficacy and safety of intranasal Ketalar (ketamine hydrochloride) in the treatment of primary symptom manifestations of pediatric bipolar disorder; Fear of Harm (FOH) phenotype. This phenotype represents those children who are most resistant to traditional treatments and suffer repeated hospitalizations. Primary symptoms include fearfulness, aggression secondary to threat, mood and/or arousal instability, and psychosis. In addition to evaluation of efficac... Read More
Gender:
ALL
Ages:
Between 6 years and 12 years
Trial Updated:
03/14/2017
Locations: Individual homes of subjects, Not Predetermined, Connecticut +3 locations
Conditions: Bipolar Disorder
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PET Imaging of mGLuR5 With Drug Challenge
NCT01691092
Completed
This study is designed to look at that involvement of a process in the brain called the glutamate system in depression. Participants will undergo a screening session, up to two functional Magnetic Resonance Imaging (fMRI) scans, and up to three Positron Emission Tomography (PET) scans, as well as cognitive testing at each scan session. For one of the PET scans, a drug (either ketamine or n-acetyl cysteine) will be administered. Hypothesis 1: The investigators hypothesize administration of ketam... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/10/2017
Locations: Connecticut Mental Health Center, New Haven, Connecticut +2 locations
Conditions: Major Depressive Disorder, Post-Traumatic Stress Disorder (PTSD)
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The Impact of Ketamine on the Reward Circuitry of Suicidal Patients
NCT02532153
Withdrawn
Every 40 seconds, someone in the world dies by suicide. There is a lack of effective and safe antisuicidal agents for preventing suicide attempts. This leads to the immense worldwide individual, financial, and societal burden of suicide-which is projected to rise in the coming decades-supporting the need for antisuicidal treatments. This treatment gap may be filled through understanding the neurobiology of suicide, which can guide the development of targeted antisuicidal treatments. Though some... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
03/01/2017
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Suicidal Ideation, Suicide
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Cognitive Behavioral Therapy in Prolonging the Antidepressant Effects of Intravenous Ketamine
NCT02289248
Completed
Subjects with depressive episodes will be recruited to undergo a brief 2 week course of IV infusions of ketamine in combination with cognitive behavioral therapy for 8 weeks.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
02/27/2017
Locations: Connecticut Mental Health Center, New Haven, Connecticut +1 locations
Conditions: Depression
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Efficacy Study of Ketamine for Postoperative Pain in Opioid Dependent Patients
NCT01591382
Completed
Patients who are dependent on opioids often have poor pain relief after major surgery. This study tests the hypothesis that adding intravenous ketamine to a postoperative regimen of intravenous opioids for postoperative pain will improve pain relief in this subset of patients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/01/2017
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Postoperative Pain
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Pilot Study of Ketamine in Adults With Obsessive-Compulsive Disorder (OCD)
NCT01100255
Completed
In this study investigators are studying the effects of a drug called ketamine on the symptoms of Obsessive-compulsive disorder (OCD).
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
01/03/2017
Locations: New York State Psychiatric Institute, New York, New York
Conditions: Obsessive-Compulsive Disorder
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Intranasal Ketamine in Treatment-Resistant Depression
NCT01304147
Completed
The objective of the current study is to investigate the safety and efficacy of a single dose of intranasal (IN) ketamine in treatment-resistant depression (TRD).
Gender:
ALL
Ages:
Between 21 years and 65 years
Trial Updated:
12/16/2016
Locations: Icahn School of Medicine at Mount Sinai, New York City, New York
Conditions: Major Depressive Disorder
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Ketamine For Suicidal Ideation
NCT01507181
Completed
This study will examine the effects of Intravenous (IV) ketamine both in an outpatient population and with subjects on the inpatient unit with suicidal ideation (SI).
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
12/16/2016
Locations: Icahn School of Medicine at Mount Sinai, New York, New York
Conditions: Suicidal Ideation
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Compare the Effect of Propofol vs. "Ketofol" on Hemodynamic Stability During Induction of General Anesthesia
NCT02282891
Withdrawn
The purpose of this study is to compare the hemodynamic effects of a standardized induction of general anesthesia with either propofol or ketofol in patients with physical status classification ASA 3. The study will be a double blinded, randomized controlled trial (RCT) with two arms of treatment groups. One arm will consist of induction of general anesthesia using a mixture of 1.5mg/kg:0.75mg/kg Propofol/ketamine (ketofol) and the induction dose will be 1.5mg/kg of propofol and 0.75mg/kg of ket... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
12/14/2016
Locations: Yale New Haven Hospital, New Haven, Connecticut
Conditions: Patients With "ASA 3" Designation
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A Study to Investigate Evoked Potentials as Markers of Ketamine-induced Cortical Plasticity in Patients With Major Depressive Disorder
NCT01957410
Terminated
To evaluate if somatosensory evoked potentials (SEPs) and motor evoked potentials (MEPs) obtained with electroencephalography (EEG) and electromyography (EMG) can be used to detect changes in cortical plasticity in responders to a single IV infusion of ketamine as compared to non-responders.
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
12/05/2016
Locations: Not set, Durham, North Carolina
Conditions: Major Depressive Disorder
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Ketamine in Chronic Kid's (KiCK) Pain
NCT01755169
Terminated
This study is designed to select the most tolerable dose of oral ketamine for children with chronic pain. Children will be given either placebo or one of three dosages of oral ketamine for 2 weeks. The dosage that is most tolerable will be selected for further study.
Gender:
ALL
Ages:
Between 8 years and 20 years
Trial Updated:
11/28/2016
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Chronic Pain
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