There are currently 334 clinical trials in Norfolk, Virginia looking for participants to engage in research studies. Trials are conducted at various facilities, including Children's Hospital of The King's Daughters, Sentara Norfolk General Hospital, Virginia Oncology Associates and Eastern Virginia Medical School. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice and Pembrolizumab in Patients With Previously Untreated, Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer
NCT05382286
Recruiting
The primary objective of this study is to compare the progression-free survival (PFS) between sacituzumab govitecan-hziy (SG) and pembrolizumab versus treatment of physician's choice (TPC) and pembrolizumab in participants with previously untreated, locally advanced inoperable or metastatic triple-negative breast cancer, whose tumors express programmed cell death ligand 1 (PD-L1).
Gender:
All
Ages:
18 years and above
Trial Updated:
05/08/2024
Locations: Virginia Oncology Associates, Norfolk, Virginia
Conditions: Triple Negative Breast Cancer, PD-L1 Positive
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Multi-Center Study of Panosyl-Isomaltooligosaccharides Adjunctive to PPI Therapy to Treat GERD
NCT05556824
Recruiting
This study will be conducted as a multi-center, randomized, double-blind, placebo-controlled trial to evaluate the effect of MHS-1031 on heartburn-free days in subjects with GERD-related heartburn symptoms.
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
05/08/2024
Locations: Digestive Disease and Liver Specialists, Norfolk, Virginia
Conditions: Gastroesophageal Reflux
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PARTNER 3 Trial - Aortic Valve-in-Valve
NCT03003299
Recruiting
This study will assess the safety and effectiveness of the SAPIEN 3/SAPIEN 3 Ultra transcatheter heart valve (THV) in patients with a failing aortic bioprosthetic valve.
Gender:
All
Ages:
All
Trial Updated:
05/08/2024
Locations: Sentara Cardiovascular Research Institute, Norfolk, Virginia
Conditions: Aortic Stenosis, Aortic Stenosis, Severe
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A Study to Test if Fremanezumab is Effective in Preventing Migraine in Children and Adolescents
NCT04530110
Recruiting
The primary objective of the study is to evaluate the long-term safety and tolerability of subcutaneous fremanezumab in the preventive treatment of migraine in pediatric participants 6 to 17 years of age (inclusive at enrollment in the pivotal study). Secondary objectives are to evaluate the efficacy of subcutaneous fremanezumab in pediatric participants with migraine and to evaluate the immunogenicity of fremanezumab and the impact of ADAs on clinical outcomes in pediatric participants exposed... Read More
Gender:
All
Ages:
Between 6 years and 17 years
Trial Updated:
05/07/2024
Locations: Teva Investigational Site 14323, Norfolk, Virginia
Conditions: Migraine
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Trans-Abdominal Fetal Pulse Oximetry - EFS-IDE
NCT06405984
Recruiting
The Lumerah System, developed and manufactured by Raydiant Oximetry, Inc., is a non-invasive fetal pulse oximeter that measures fetal arterial oxygen saturation using safe, non-invasive, transabdominal near-infrared spectroscopy. The Lumerah System is intended as an adjunct to cardiotocography. In this study, women in labor will also be simultaneously monitored with a re-engineered version of the previously approved transvaginal oximeter sensor connected to a Nellcor N-400 fetal oximetry monitor... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
05/06/2024
Locations: Sentara Norfolk General - Eastern Virginia Medical School, Norfolk, Virginia
Conditions: Fetal Hypoxia, Fetal Distress, Fetal Conditions, Fetal Complications, Labor Fetal Anoxia, Labor (Obstetrics)--Complications, Oxygen Deficiency
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Ultrasound Findings in Diabetic Pregnancies
NCT06407388
Recruiting
The goal of our study is to identify ultrasonographic markers that can predict adverse neonatal outcomes. Specifically, we hypothesize that an increase in fetal liver volumes will increase transcutaneous bilirubin (TcB) in the newborn and thus jaundice requiring phototherapy. This information can be used in patient counseling and to guide future screening protocols for ultrasound in individuals with diabetes.
Gender:
Female
Ages:
Between 18 years and 45 years
Trial Updated:
05/06/2024
Locations: Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Eastern Virginia Medical School, Norfolk, Virginia
Conditions: Diabetes
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An Open-label Study Comparing Lutetium (177Lu) Vipivotide Tetraxetan Versus Observation in PSMA Positive OMPC.
NCT05939414
Recruiting
The purpose of this study is to evaluate the efficacy and safety of lutetium (177Lu) vipivotide tetraxetan (AAA617) in participants with oligometastatic prostate cancer (OMPC) progressing after definitive therapy to their primary tumor. The data generated from this study will provide evidence for the treatment of AAA617 in early-stage prostate cancer patients to control recurrent tumor from progressing to fatal metastatic disease while preserving quality of life by delaying treatment with androg... Read More
Gender:
Male
Ages:
18 years and above
Trial Updated:
05/02/2024
Locations: Virginia Oncology Associates ., Norfolk, Virginia
Conditions: Oligometastatic Prostate Cancer (OMPC)
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SELUTION4BTK Trial
NCT05055297
Recruiting
This study aims to demonstrate superior efficacy and equivalent safety of the SELUTION SLR™ DEB 014 compared to plain (uncoated) balloon angioplasty in the treatment of peripheral arterial disease (PAD) in the BTK arteries in CLTI patients.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/02/2024
Locations: Sentara Norfolk General Hospital, Norfolk, Virginia
Conditions: Peripheral Arterial Disease, Chronic Limb-Threatening Ischemia Nos of Native Arteries of Extremities
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Safety and Efficacy Study of Intracystic TARA-002 for the Treatment of Lymphatic Malformations in Participants 6 Months to Less Than 18 Years of Age
NCT05871970
Recruiting
This is a Phase 2a/b single arm open label study to evaluate the safety, reactogenicity, and efficacy of intracystic injection of TARA-002 in participants 6 months to less than 18 years of age for the treatment of macrocystic and mixed cystic lymphatic malformations. The Phase 2a safety lead-in, age de-escalation study is designed to establish the safety of TARA-002 in older participants 6 years to less than 18 years before proceeding to younger participants 2 years to less than 6 years, then 6... Read More
Gender:
All
Ages:
Between 6 months and 18 years
Trial Updated:
05/01/2024
Locations: Children's Hospital of the King's Daughters, Norfolk, Virginia
Conditions: Lymphatic Malformation
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A Study of Ianalumab (VAY736) in Patients With Primary Immune Thrombocytopenia (ITP) Previously Treated With at Least Two Lines of Therapies
NCT05885555
Recruiting
The purpose of this study is to evaluate the therapeutic efficacy, safety and tolerability of ianalumab in adult patients with primary ITP previously treated with at least one corticosteroid and one TPO-RA.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/01/2024
Locations: Virginia Oncology Associates ., Norfolk, Virginia
Conditions: Primary Immune Thrombocytopenia (ITP)
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Medtronic Terminate AF Study
NCT03546374
Recruiting
The purpose of this study is to demonstrate the safety and effectiveness of the Cardioblate iRF and CryoFlex hand held devices for the treatment of non-paroxysmal AF.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/01/2024
Locations: Sentara Norfolk General Hospital, Norfolk, Virginia
Conditions: Persistent Atrial Fibrillation, Longstanding Persistent Atrial Fibrillation
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Prostate Active Surveillance Study
NCT00756665
Recruiting
The Prostate Active Surveillance Study (PASS) is a research study for men who have chosen active surveillance as a management plan for their prostate cancer. Active surveillance is defined as close monitoring of prostate cancer with the offer of treatment if there are changes in test results. This study seeks to discover markers that will identify cancers that are more aggressive from those tumors that grow slowly.
Gender:
Male
Ages:
21 years and above
Trial Updated:
04/30/2024
Locations: Eastern Virginia Medical School, Norfolk, Virginia
Conditions: Prostatic Neoplasms
Register for Updates