Oregon is currently home to 1217 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Portland, Eugene, Medford and Clackamas. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
AB-101 as Monotherapy and With Immunotherapy in Patients With Relapsed/Refractory B-Cell Non-Hodgkin Lymphoma
NCT04673617
Recruiting
AB-101 is an off-the shelf, allogeneic cell product made of "natural killer" cells, also called NK cells. White blood cells are part of the immune system and NK cells are a type of white blood cell that are known to kill cancer cells. This clinical trial will enroll patients with relapsed/refractory non-Hodgkin lymphoma of B-cell origin and is conducted in two phases. The primary objectives of Phase 1 are as follows: 1) to evaluate the safety of AB-101 given alone or in combination with rituxim... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/09/2024
Locations: Oregon Health Sciences Center, Portland, Oregon
Conditions: Non Hodgkin Lymphoma
Register for Updates
Optimizing Sleep Health in Nurses
NCT05965609
Recruiting
The aim of the proposed study is to pilot test two behavioral sleep intervention strategies for improving insomnia among night shift working nurses.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/08/2024
Locations: Oregon State University, Corvallis, Oregon
Conditions: Circadian Rhythm Sleep-Wake Disorders, Shift Work Type, Sleep Initiation and Maintenance Disorders
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Scleral Lens Fitting Using Wide-Field OCT
NCT04570020
Recruiting
The purpose of this study is to see if OCT technology can optimize scleral contact lens fittings. Subjects with keratoconus, post-penetrating keratoplasty (PK), post-LASIK ectasia, post-radial keratotomy (RK), or a variety of anterior surface disorders requiring scleral lens fittings will be considered for enrollment. For each study eye, a clinically-selected scleral lens fit will be compared against an OCT-selected lens fit. The quality of each lens fit will be determined by flourescein exam at... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/08/2024
Locations: Oregon Health & Science University, Casey Eye Institute, Portland, Oregon
Conditions: Keratoconus, Irregular; Contour of Cornea
Register for Updates
OCT in Fuchs' Dystrophy
NCT04258787
Recruiting
This is an observational study using optical coherence tomography (OCT) technology to quantify corneal edema in Fuchs' endothelial dystrophy and predict refractive shift from resolving corneal edema after surgical treatments.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/08/2024
Locations: Oregon Health & Science University, Portland, Oregon
Conditions: Fuchs Dystrophy, Pseudophakic Bullous Keratopathy
Register for Updates
Observational Study of Iris Tumors
NCT03809585
Recruiting
This is an observational study using OCT angiography to assist with tumor characterization in melanotic and amelanotic iris lesions. OCT angiography data from healthy eyes will be compared to eyes with various types of iris tumors.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/08/2024
Locations: Oregon Health & Science University, Portland, Oregon
Conditions: Iris Tumor
Register for Updates
OCT Angiography and NRAI in Dementia
NCT03761381
Recruiting
The primary goals of this study are to use optical coherence tomography (OCT) angiography (blood vessel mapping) to: Detect retinal blood vessel and blood flow changes in participants with dementia. Detect amyloid protein deposits in the retinas of participants with dementia.
Gender:
All
Ages:
55 years and above
Trial Updated:
02/08/2024
Locations: Oregon Health & Science University, Portland, Oregon
Conditions: Alzheimer Disease, Dementia, Mild Cognitive Impairment
Register for Updates
Collagen Cross-linking in Keratoconus
NCT03760432
Recruiting
Optical Coherence Tomography (OCT) devices are non-contact instruments that can measure the depth of scars, other causes of cloudiness of the cornea, and degree of corneal thinning in patients with keratoconus. Laser Custom Corneal Collagen Cross-linking (CXL) significantly decreases corneal aberrations and improves vision. This study will use OCT-guided setting for the lasers used in the corneal smoothing portion of the laser custom CXL procedure to assess the affect on visual outcomes.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/08/2024
Locations: Oregon Health & Science University, Portland, Oregon
Conditions: Keratoconus
Register for Updates
OCT Angiography in Wet AMD
NCT02253030
Recruiting
The primary goals of this study are to use optical coherence tomography (OCT) angiography (blood vessel mapping) to: diagnose the presence of new blood vessels in wet age-related macular degeneration (AMD) evaluate patients undergoing treatment for wet AMD determine if reduced flow to the choroid is a risk factor for developing wet AMD.
Gender:
All
Ages:
Between 50 years and 100 years
Trial Updated:
02/08/2024
Locations: Casey Eye Institute, Oregon Health & Science University, Portland, Oregon
Conditions: Neovascular (Wet) Age-related Macular Degeneration (AMD)
Register for Updates
OCT in Rare Chorioretinal Diseases
NCT02141308
Recruiting
This study will evaluate the total blood flow in the retina and choroid (structures in the back of the eye) by Doppler optical coherence tomography (OCT) and OCT angiography. Angiography is mapping of the blood vessels. The purpose of measuring blood flow in the retina and choroid is to 1.) determine if rare diseases in these structures causes a change in blood flow compared to healthy eyes and 2.) find out if areas of changed blood flow line up with areas of damage that appear on conventional... Read More
Gender:
All
Ages:
Between 7 years and 100 years
Trial Updated:
02/08/2024
Locations: Casey Eye Institute, Oregon Health & Science University, Portland, Oregon
Conditions: Retinal Artery Occlusions, Polypoidal Choroidal Vasculopathy, Retinal Arterial Macroaneurysm, Juxtafoveal Telangiecasia, Central Serous Chorioretinopathy
Register for Updates
Observational Study of Corneal Opacities in Adults
NCT02109471
Recruiting
A prospective observational study on corneal opacities (scar and stromal dystrophy) in adults (n=150) will be conducted at OHSU. The Optovue anterior segment OCT will be used to perform 3-D corneal scans. These scans will be used to assess opacity depth and measure corneal thickness (pachymetry), corneal topography (anterior and posterior), and epithelial thickness maps. The ultrahigh-speed MIT OCT prototypes will also be used when they become available. A comprehensive eye examination, Placido-... Read More
Gender:
All
Ages:
Between 18 years and 100 years
Trial Updated:
02/08/2024
Locations: Humberto Martinez, Portland, Oregon
Conditions: Corneal Opacities (Scar and Stromal Dystrophy)
Register for Updates
Optical Coherence Tomography (OCT) in Uveitis
NCT02026128
Recruiting
Optical Coherence Tomography (OCT) machines are non-contact instruments that can provide micrometer (one one-thousandths) scale imaging of biological tissue. This allows excellent assessment of the white blood and inflammatory cells seen in uveitis, an inflammation of any or all parts of the uvea (iris, ciliary body, choroid).
Gender:
All
Ages:
18 years and above
Trial Updated:
02/08/2024
Locations: Oregon Health & Science University, Portland, Oregon
Conditions: Uveitis
Register for Updates
Optical Coherence Tomography Guided Transepithelial Phototherapeutic Keratectomy
NCT01243931
Recruiting
Optical Coherence Tomography (OCT) machines are non-contact instruments that can measure the depth of scars and other causes of cloudiness in the front of the cornea. The purpose of this study is to determine whether OCT-guided settings for the lasers used for removal of corneal scars and other partial-thickness corneal defects result in improved vision in patients receiving these procedures.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/08/2024
Locations: Casey Eye Institute, Oregon Health & Science University, Portland, Oregon
Conditions: Corneal Opacity
Register for Updates