Oregon is currently home to 1215 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Portland, Eugene, Medford and Clackamas. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Biomarker Verification in Pediatric Chronic GvHD: ABLE 2.0 / PTCTC GVH 1901 Study
NCT04372524
Recruiting
This study will validate a previously developed pediatric prognostic biomarker algorithm aimed at improving prediction of risk for the later development of chronic graft-versus-host disease (cGvHD) in children and young adults undergoing allogeneic hematopoietic stem cell transplant. By developing an early risk stratification of patients into low-, intermediate-, and high-risk for future cGvHD development (based upon their biomarker profile, before the onset of cGvHD), pre-emptive therapies aim... Read More
Gender:
ALL
Ages:
Between 0 years and 24 years
Trial Updated:
12/02/2023
Locations: Oregon Health & Science University Knight Cancer Institute, Portland, Oregon
Conditions: Chronic Graft-versus-Host-Disease, Leukemia, Allogeneic Hematopoietic Stem Cell Transplantation, Blood Cancer, Non-Malignant Hematologic and Lymphocytic Disorder
Register for Updates
Sleep Management And Recovery After Traumatic Brain Injury in Kids: Pilot Intervention of Melatonin
NCT04932096
Recruiting
Sleep wake disturbances compound recovery in over half of pediatric traumatic brain injury survivors, leading to impaired quality of life, and few effective interventions exist to treat this important morbidity. Therefore, this study will conduct a randomized controlled trial evaluating a melatonin intervention started during hospitalization and continued after discharge compared to placebo. The trial will investigate if this intervention is feasible, acceptable, and effective at reducing sleep... Read More
Gender:
ALL
Ages:
Between 6 years and 18 years
Trial Updated:
11/14/2023
Locations: Oregon Health & Science University, Portland, Oregon
Conditions: Traumatic Brain Injury, Critical Illness, Sleep
Register for Updates
A Prospective Analysis of Long-Term Clinical Outcomes and 3D Spine Growth in Anterior Vertebral Body Tethering
NCT04914507
Recruiting
Anterior vertebral body tethering (AVBT) is a novel, minimally invasive, growth modulation technique that was recently approved by the FDA under a Humanitarian Device Exemption (HDE). The goal of AVBT is to control curve progression by applying compression on the convex side of the spine deformity. While there has been great initial enthusiasm about the technique as an alternate treatment option to spinal fusion for skeletally immature children with scoliosis, there is a need to better understan... Read More
Gender:
ALL
Ages:
18 years and below
Trial Updated:
11/14/2023
Locations: Shriners Children's Portland, Portland, Oregon
Conditions: Scoliosis Idiopathic
Register for Updates
Body Composition Changes After TIPS and Associated Clinical Outcomes
NCT05420753
Recruiting
The purpose of this study is to prospectively assess the impact of TIPS creation on muscle mass and physical function in patients with cirrhosis, and to determine whether these changes correlate with improved outcomes in patients awaiting liver transplantation. Retrospective observational studies have shown improvement in muscle mass and body composition in cirrhotic patients undergoing TIPS. The investigators aim to now prospectively study this through a pilot randomized controlled trial tracki... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
11/02/2023
Locations: Oregon Health and Science University, Portland, Oregon
Conditions: Cirrhosis, Liver, Sarcopenia
Register for Updates
Promoting Math in Young Children: Leveraging Pediatric Clinics to Reach Underrepresented Children in Rural Communities
NCT05884541
Recruiting
The goals of this clinical trial to examine how pediatricians prescribing early math enriching texts to the parents of their patients affects the early math skills of under-resourced pre-kindergarten-aged children in rural Oregon. The main question it aims to answer is: What is the impact of the text intervention on early math skills in preschool-aged children? Participants will be randomized to receive the early math text intervention or standard of care. Researchers will compare pre-and-post m... Read More
Gender:
ALL
Ages:
Between 36 months and 59 months
Trial Updated:
10/30/2023
Locations: Oregon Rural Practice Research Network, Portland, Oregon
Conditions: Early Math Learning
Register for Updates
COmbination Therapy With Baloxavir and Oseltamivir 1 for Hospitalized Patients With Influenza (The COMBO Trial 1)
NCT04327791
Recruiting
This is a randomized, double-blind, placebo-controlled Phase 2-like, investigator-directed trial of hospitalized patients with laboratory confirmed influenza. Eligible and consented patients will be randomly assigned, in a 1:1 ratio, to one of two groups: Group 1, the combination treatment group (oseltamivir and baloxavir); Group 2, the standard treatment group (oseltamivir and placebo).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/27/2023
Locations: Oregon Health & Science University, Portland, Oregon
Conditions: Influenza
Register for Updates
Caloric Restriction and Activity to Reduce Chemoresistance in B-ALL
NCT05082519
Recruiting
This study is for older children, adolescents, and young adults with B-cell Acute Lymphoblastic Leukemia (B-ALL). Higher amounts of body fat is associated with resistance to chemotherapy in patients with B-ALL. Chemotherapy during the first month causes large gains in body fat in most people, even those who start chemotherapy at a healthy weight. This study is being done to find out if caloric restriction achieved by a personalized nutritional menu and exercise plan during routine chemotherapy... Read More
Gender:
ALL
Ages:
Between 10 years and 25 years
Trial Updated:
10/25/2023
Locations: Oregon Health & Science University, Portland, Oregon
Conditions: B-cell Acute Lymphoblastic Leukemia, Obesity
Register for Updates
Supported Employment COVID-19 Rapid Testing for PWID
NCT05984966
Recruiting
This community-engaged project aims to improve the accessibility of rapid tests through a supported employment program for people who inject drugs (PWID). The program is called Peer Connect2Test (PeerC2T). PWID will be recruited by a community partner who provides syringe exchange services. PWID will the trained by the community partner to become peer health workers (PHW) to distribute SARS-CoV-2 rapid tests to other PWID. Investigators expect that PeerC2T will improve knowledge, self-efficacy,... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/06/2023
Locations: University of Oregon, Eugene, Oregon
Conditions: Health Behavior
Register for Updates
Immunogenicity of Yellow Fever Vaccine 17D in Adults With Prior 17D Vaccination
NCT05859490
Recruiting
The goal of this clinical trial is to assess the immune response to the yellow fever vaccine 17D in adults with prior 17D vaccination. The main questions this study aims to answer are: * how does prior vaccination affect antibody responses to re-vaccination? * how does prior vaccination affect the immune cell response to re-vaccination? Participants will: * have been previously vaccinated with 17D. * be re-vaccinated with 17D. * provide medical and travel histories. * provide a blood sample p... Read More
Gender:
ALL
Ages:
Between 20 years and 49 years
Trial Updated:
09/26/2023
Locations: Oregon Health & Science University, Portland, Oregon
Conditions: Yellow Fever, Immunization; Infection
Register for Updates
Whole Genome Sequencing (WGS) on IVF Embryos and Individual Patients
NCT05739890
Recruiting
This research project aims to utilise recent advances in whole genome sequencing of preimplantation genetic diagnosis embryos to investigate the impact of paternal age on de novo mutation rates in IVF embryos. Embryos that are deemed unsuitable for transfer following preimplantation genetic testing for monogenic/single gene disorders (PGT-M) due to the detection of genetic abnormalities will be utilized for this study. These embryos will undergo re-biopsy, and both the biopsied samples as well a... Read More
Gender:
ALL
Ages:
Between 18 years and 48 years
Trial Updated:
09/21/2023
Locations: ORM Fertility, Portland, Oregon
Conditions: Fertility Issues, Single-Gene Defects
Register for Updates
Resilience, Grit, and Stress in Medical Students
NCT06046183
Recruiting
The incidence of burnout and mental ill-health begins very early in medical school and continues to be high throughout training. Medical students are under high amounts of stress, which often becomes chronic, and can lead to both physical and psychological issues as a student, resident, and physician. Chronic stress and burnout in medical students are not a new phenomenon, but recent research has highlighted the worsening mental health of medical students, with as high as three-quarters of stude... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
09/13/2023
Locations: Western University of Health Science, College of Osteopathic Medicine of the Pacific - Northwest, Lebanon, Oregon
Conditions: Stress, Psychological
Register for Updates
Part II: Granulocyte-Colony Stimulating Factor Adjunct Therapy for Biliary Atresia
NCT04373941
Recruiting
The Investigators propose to test the hypothesis that GCSF enhances the clinical outcome of biliary atresia in a multi-institutional Phase 2 trial to prospectively evaluate the safety and efficacy of GCSF in each of the 2 groups of newly diagnosed BA patients: KBA (i.e., Kasai-operated) or NoK (i.e., patients who did not undergo Kasai surgery). Subjects who participate in the trial will be followed for 2 years.
Gender:
ALL
Ages:
Between 14 days and 180 days
Trial Updated:
09/07/2023
Locations: Oregon Health & Science University (OHSU), Portland, Oregon
Conditions: Biliary Atresia
Register for Updates