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Carboplatin Treatment Options in Canada
A collection of 336 research studies where Carboplatin is the interventional treatment. These studies are located in the Canada . Carboplatin is used for conditions such as Non-Small Cell Lung Cancer, Ovarian Cancer and Lung Cancer.
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Durvalumab Treatment in Combination With Chemotherapy and Bevacizumab, Followed by Maintenance Durvalumab, Bevacizumab and Olaparib Treatment in Advanced Ovarian Cancer Patients
Active Not Recruiting
This is a Phase III randomised, double-blind, multi-centre study to evaluate the efficacy and safety of durvalumab in combination with standard of care platinum based chemotherapy and bevacizumab followed by maintenance durvalumab and bevacizumab or durvalumab, bevacizumab and olaparib in patients with newly diagnosed advanced ovarian cancer.
This is a Phase III randomised, double-blind, multi-centre study to evaluate the efficacy and safety of durvalumab in combination with standard of care platinum based chemotherapy and bevacizumab followed by maintenance durvalumab and bevacizumab or durvalumab, bevacizumab and olaparib in patients with newly diagnosed advanced ovarian cancer. Read Less
Gender:
FEMALE
Ages:
Between 18 years and 130 years
Trial Updated:
01/28/2025
Locations: Research Site, Foothill Ranch, California +213 locations
Research Site, Foothill Ranch, California
Research Site, Los Angeles, California
Research Site, Orange, California
Research Site, San Francisco, California
Research Site, Tampa, Florida
Research Site, Augusta, Georgia
Research Site, Hinsdale, Illinois
Research Site, Indianapolis, Indiana
Research Site, Towson, Maryland
Research Site, Detroit, Michigan
Research Site, Springfield, Missouri
Research Site, Middletown, New Jersey
Research Site, Montvale, New Jersey
Research Site, Albany, New York
Research Site, New York, New York
Research Site, Uniondale, New York
Research Site, Durham, North Carolina
Research Site, Cleveland, Ohio
Research Site, Dayton, Ohio
Research Site, Hilliard, Ohio
Research Site, Tulsa, Oklahoma
Research Site, Lancaster, Pennsylvania
Research Site, Philadelphia, Pennsylvania
Research Site, Philadelphia, Pennsylvania
Research Site, Pittsburgh, Pennsylvania
Research Site, Salt Lake City, Utah
Research Site, Graz, Not set
Research Site, Innsbruck, Not set
Research Site, Linz, Not set
Research Site, Wien, Not set
Research Site, Aalst, Not set
Research Site, Leuven, Not set
Research Site, Namur, Not set
Research Site, Oostende, Not set
Research Site, Sint-Niklaas, Not set
Research Site, Barretos, Not set
Research Site, Florianópolis, Not set
Research Site, Fortaleza, Not set
Research Site, Londrina, Not set
Research Site, Porto Alegre, Not set
Research Site, Porto Alegre, Not set
Research Site, Rio de Janeiro, Not set
Research Site, Sao Paulo, Not set
Research Site, São Paulo, Not set
Research Site, Burgas, Not set
Research Site, Plovdiv, Not set
Research Site, Sofia, Not set
Research Site, Varna, Not set
Research Site, Calgary, Alberta
Research Site, Barrie, Ontario
Research Site, Sudbury, Ontario
Research Site, Toronto, Ontario
Research Site, Montreal, Quebec
Research Site, Montreal, Quebec
Research Site, Montreal, Quebec
Research Site, Rimouski, Quebec
Research Site, Quebec, Not set
Research Site, Beijing, Not set
Research Site, Beijing, Not set
Research Site, Bengbu, Not set
Research Site, Changchun, Not set
Research Site, Changsha, Not set
Research Site, Changsha, Not set
Research Site, Chengdu, Not set
Research Site, Chongqing, Not set
Research Site, Dalian, Not set
Research Site, Guangzhou, Not set
Research Site, Guangzhou, Not set
Research Site, Hangzhou, Not set
Research Site, Hangzhou, Not set
Research Site, Harbin, Not set
Research Site, Hefei, Not set
Research Site, Jinhua, Not set
Research Site, Kunming, Not set
Research Site, Lanzhou, Not set
Research Site, Luzhou, Not set
Research Site, Nan Chong, Not set
Research Site, Nanjing, Not set
Research Site, Nanning, Not set
Research Site, Nantong, Not set
Research Site, Shanghai, Not set
Research Site, Shanghai, Not set
Research Site, Wuhan, Not set
Research Site, Wuhan, Not set
Research Site, Xi'an, Not set
Research Site, Zhengzhou, Not set
Research Site, Zhengzhou, Not set
Research Site, Zhuhai, Not set
Research Site, Aalborg, Not set
Research Site, Aarhus N, Not set
Research Site, Odense, Not set
Research Site, Roskilde, Not set
Research Site, Vejle, Not set
Research Site, Kuopio, Not set
Research Site, Oulu, Not set
Research Site, Turku, Not set
Research Site, Besançon, Not set
Research Site, Bordeaux, Not set
Research Site, Limoges Cedex, Not set
Research Site, Lyon Cedex 08, Not set
Research Site, Marseille, Not set
Research Site, Nantes, Not set
Research Site, Paris Cedex 14, Not set
Research Site, Paris, Not set
Research Site, Paris, Not set
Research Site, Saint Herblain Cedex, Not set
Research Site, Vandoeuvre les Nancy, Not set
Research Site, Bad Homburg, Not set
Research Site, Berlin, Not set
Research Site, Bielefeld, Not set
Research Site, Bonn, Not set
Research Site, Brandenburg, Not set
Research Site, Dresden, Not set
Research Site, Düsseldorf, Not set
Research Site, Essen, Not set
Research Site, Essen, Not set
Research Site, Esslingen am Neckar, Not set
Research Site, Frankfurt, Not set
Research Site, Freiburg, Not set
Research Site, Fürth, Not set
Research Site, Greifswald, Not set
Research Site, Gütersloh, Not set
Research Site, Hamburg, Not set
Research Site, Hamburg, Not set
Research Site, Hamburg, Not set
Research Site, Hannover, Not set
Research Site, Hannover, Not set
Research Site, Jena, Not set
Research Site, Karlsruhe, Not set
Research Site, Karlsruhe, Not set
Research Site, Kassel, Not set
Research Site, Kiel, Not set
Research Site, Köln, Not set
Research Site, Leipzig, Not set
Research Site, Ludwigsburg, Not set
Research Site, Lübeck, Not set
Research Site, Mainz, Not set
Research Site, Mannheim, Not set
Research Site, München, Not set
Research Site, Offenbach am Main, Not set
Research Site, Oldenburg, Not set
Research Site, Rosenheim, Not set
Research Site, Rostock, Not set
Research Site, Saalfeld, Not set
Research Site, Schweinfurt, Not set
Research Site, Tübingen, Not set
Research Site, Ulm, Not set
Research Site, Worms, Not set
Research Site, Budapest, Not set
Research Site, Budapest, Not set
Research Site, Debrecen, Not set
Research Site, Győr, Not set
Research Site, Kaposvár, Not set
Research Site, Szeged, Not set
Research Site, Zalaegerszeg, Not set
Research Site, Brescia, Not set
Research Site, Lecce, Not set
Research Site, Lecco, Not set
Research Site, Milano, Not set
Research Site, Milano, Not set
Research Site, Mirano, Not set
Research Site, Napoli, Not set
Research Site, Reggio Calabria, Not set
Research Site, Reggio Emilia, Not set
Research Site, Roma, Not set
Research Site, Torino, Not set
Research Site, Torino, Not set
Research Site, Fukuoka-shi, Not set
Research Site, Kashiwa-shi, Not set
Research Site, Kobe-shi, Not set
Research Site, Koto-ku, Not set
Research Site, Kurume-shi, Not set
Research Site, Kyoto-shi, Not set
Research Site, Minato-ku, Not set
Research Site, Nagoya-shi, Not set
Research Site, Niigata-shi, Not set
Research Site, Okayama-shi, Not set
Research Site, Sapporo-shi, Not set
Research Site, Sendai-shi, Not set
Research Site, Shinjuku-ku, Not set
Research Site, Sunto-gun, Not set
Research Site, Toyoake-shi, Not set
Research Site, Goyang-si, Not set
Research Site, Seongnam-si, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Suwon-si, Not set
Research Site, Bellavista, Not set
Research Site, La Libertad, Not set
Research Site, Lima, Not set
Research Site, Lima, Not set
Research Site, Lima, Not set
Research Site, Lima, Not set
Research Site, San Isidro, Not set
Research Site, Gdynia, Not set
Research Site, Szczecin, Not set
Research Site, Warszawa, Not set
Research Site, Warszawa, Not set
Research Site, Łódź, Not set
Research Site, Floresti, Not set
Research Site, Córdoba, Not set
Research Site, Madrid, Not set
Research Site, Madrid, Not set
Research Site, Madrid, Not set
Research Site, Madrid, Not set
Research Site, Terrassa(Barcelona), Not set
Research Site, Vigo, Not set
Research Site, Adana, Not set
Research Site, Ankara, Not set
Research Site, Ankara, Not set
Research Site, Istanbul, Not set
Research Site, Istanbul, Not set
Research Site, Izmir, Not set
Conditions: Advanced Ovarian Cancer
Avelumab in First-line NSCLC (JAVELIN Lung 100)
Completed
The purpose of this study was to demonstrate superiority with regard to Overall Survival (OS) or Progression Free Survival (PFS) of avelumab versus platinum-based doublet, based on an Independent Review Committee assessment, in Non-small cell lung cancer (NSCLC) participants with Programmed death ligand 1+ (PD-L1+) tumors.
The purpose of this study was to demonstrate superiority with regard to Overall Survival (OS) or Progression Free Survival (PFS) of avelumab versus platinum-based doublet, based on an Independent Review Committee assessment, in Non-small cell lung cancer (NSCLC) participants with Programmed death ligand 1+ (PD-L1+) tumors. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/20/2025
Locations: Clearview Cancer Institute, Huntsville, Alabama +348 locations
Clearview Cancer Institute, Huntsville, Alabama
Arizona Center for Cancer Care, Surprise, Arizona
Sharp Memorial Hospital, San Diego, California
University Cancer Institute, Boynton Beach, Florida
South Georgia Medical Center, Valdosta, Georgia
Christus Cancer Treatment Center, Shreveport, Louisiana
Henry Ford Hospital, Detroit, Michigan
St. Vincent Frontier Cancer Center, Billings, Montana
Nevada Cancer Research Foundation, Las Vegas, Nevada
San Juan Oncology Associates, Farmington, New Mexico
Novant Health Oncology Specialists, Kernersville, North Carolina
Mercy Research, Oklahoma City, Oklahoma
Kaiser Permanente Northwest, Portland, Oregon
Lancaster Cancer Center, Lancaster, Pennsylvania
Cookeville Regional Medical Center, Cookeville, Tennessee
Thompson Cancer Survival Center, Knoxville, Tennessee
Coastal Bend Cancer Center, Corpus Christi, Texas
Oncology Consultants, P.A., Houston, Texas
University of Vermont Medical Center, Burlington, Vermont
Northwest Medical Specialties, PLLC, Tacoma, Washington
Cheyenne Regional Medical Center, Cheyenne, Wyoming
Albury Wodonga Regional Cancer Centre, Albury, New South Wales
Coffs Harbour Health Campus, Coffs Harbour, New South Wales
St George Private Hospital, Kogarah, New South Wales
Lismore Base Hospital, Lismore, New South Wales
Orange Health Service, Orange, New South Wales
Royal North Shore Hospital, St Leonards, New South Wales
Calvary Mater Newcastle, Waratah, New South Wales
Gallipoli Medical Research Foundation Ltd, Greenslopes, Queensland
Gold Coast University Hospital, Southport, Queensland
The Queen Elizabeth Hospital, Woodville South, South Australia
Ballarat Base Hospital, Ballarat, Victoria
Bendigo Hospital, Bendigo, Victoria
South West Healthcare, Warrnambool, Victoria
Fiona Stanley Hospital, Murdoch, Western Australia
ZNA Middelheim, Antwerpen, Not set
A.Z. Klina, Brasschaat, Not set
CHU Ambroise Paré, Mons, Not set
NOB - Núcleo de Oncologia da Bahia, Salvador, Bahia
CRIO - Centro Regional Integrado de Oncologia, Fortaleza, Ceará
CEBROM - Centro Brasileiro de Radioterapia, Oncologia e Mastologia, Goiânia, Goiás
Hospital Erasto Gaertner - Liga Paranaense de Combate ao Câncer, Curitiba, Paraná
Hospital de Caridade de Ijuí, Ijuí, Rio Grande Do Sul
Hospital Bruno Born, Lajeado, Rio Grande Do Sul
Hospital São Vicente de Paulo, Passo Fundo, Rio Grande Do Sul
Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande Do Sul
IMV-Pesquisa Cardiologica Sociedade Simples - HMD - COR, Porto Alegre, Rio Grande Do Sul
Hospital São Lucas da PUCRS, Porto Alegre, Rio Grande Do Sul
Hospital Nossa Senhora da Conceição, Porto Alegre, Rio Grande Do Sul
CEPON - Centro de Pesquisas Oncológicas de Santa Catarina, Florianópolis, Santa Catarina
Clínica de Neoplasias Litoral Ltda., Itajaí, Santa Catarina
Hospital de Câncer de Barretos - Fundação Pio XII, Barretos, Sao Paulo
Fundação Doutor Amaral Carvalho, Jaú, Sao Paulo
CEPHO - Centro de Estudos e Pesquisas em Hematologia e Oncologia, Santo Andre, Sao Paulo
Fundação Faculdade Regional de Medicina de São José do Rio Preto, São José do Rio Preto, Sao Paulo
ICESP - Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira, São Paulo, Sao Paulo
IBCC - Instituto Brasileiro de Controle do Câncer, São Paulo, Sao Paulo
INCA - Instituto Nacional de Câncer, Rio de Janeiro, Not set
Complex Oncological Center - Ruse, EODD, Ruse, Not set
MHAT for women's health - Nadezhda, OOD, Sofia, Not set
UMHAT "Sv. Ivan Rilski", EAD, Sofia, Not set
Shato, Ead, Sofia, Not set
The Moncton Hospital, Moncton, New Brunswick
Mount Sinai Hospital, Toronto, Ontario
FALP - Fundación Arturo López Pérez, Santiago, Not set
Clinica Santa Maria, Santiago, Not set
IRAM - Instituto de Radio Medicina, Santiago, Not set
Hospital Militar de Santiago, Santiago, Not set
Hospital Clínico San Borja Arriaran, Santiago, Not set
Hospital Clínico Universidad de Chile, Santiago, Not set
Hospital Clinico Viña del Mar, Viña del Mar, Not set
Centro de Investigaciones Clinicas Viña del Mar, Viña del Mar, Not set
Beijing Cancer Hospital, Beijing, Beijing
Guangdong General Hospital, Guangzhou, Guangdong
Harbin Medical University Cancer Hospital, Harbin, Heilongjiang
Liaoning Cancer Hospital & Institute, Shenyang, Liaoning
Linyi Cancer Hospital, Linyi, Shandong
Administradora Country S.A., Bogotá, Not set
Fundación Oftalmológica de Santander - FOSCAL, Floridablanca, Not set
Hospital Pablo Tobón Uribe, Medellín, Not set
IPS IMAT- Instituto Medico de Alta Tecnologia - Oncomedica S.A., Monteria, Not set
University Clinic for Pulmonary Diseases, Zagreb, Not set
University Hospital Centre "Sestre Milosrdnice", Zagreb, Not set
Bank of Cyprus Oncology Center, Nicosia, Not set
Krajska nemocnice Liberec, a.s., Liberec, Not set
Nemocnice Na Plesi s.r.o., Nova Ves pod Plesi, Not set
Fakultni nemocnice Olomouc, Olomouc, Not set
Vitkovicka nemocnice a.s, Ostrava - Vitkovice, Not set
Thomayerova nemocnice, Praha 4 - Krc, Not set
Krajska zdravotni, a.s. - Masarykova nemocnice v Usti nad Labem, o.z., Usti nad Labem, Not set
Herning Sygehus, Herning, Not set
Roskilde Sygehus, Roskilde, Not set
North Estonia Medical Centre Foundation, Tallinn, Not set
Centre Antoine Lacassagne, Nice cedex 02, Alpes Maritimes
CHU de Strasbourg - Nouvel Hôpital Civil, Strasbourg, Bas Rhin
Hôpital Nord - AP-HM Marseille#, Marseille cedex 20, Bouches-du-Rhône
Hôpital privé Clairval, Marseille, Bouches-du-Rhône
CHU Besançon - Hôpital Jean Minjoz, Besancon Cedex, Doubs
CHU Brest - Hôpital Morvan, Brest Cedex, Finistere
Groupe Hospitalier Sud - Hôpital Haut-Lévêque, Pessac, Gironde
CHU Angers - Hôpital Hôtel Dieu#, Angers Cedex 9, Maine Et Loire
Hôpital Cochin, Paris cedex 14, Paris
Centre Hospitalier de la Côte Basque, Bayonne, Pyrenees Atlantiques
Centre Hospitalier de la Croix Rousse, Lyon cedex 04, Rhone
Clinique Victor Hugo - Centre Jean Bernard, Le Mans Cedex 02, Sarthe
Institut Sainte Catherine, Avignon Cedex 9, Vaculuse
Centre Hospitalier Intercommunal de Créteil, Creteil cedex, Val De Marne
Hôpital Saint-Louis - Paris, Paris Cedex 10, Not set
Universitaetsklinikum Heidelberg, Heidelberg, Baden Wuerttemberg
LungenClinic Grosshansdorf GmbH, Grosshansdorf, Schleswig Holstein
251 General Air Force Hospital, Athens, Not set
General Hospital of Athens of Chest Diseases "SOTIRIA", Athens, Not set
University General Hospital "Attikon", Athens, Not set
General Oncology Hospital of Kifissia " Agioi Anargyroi", Athens, Not set
Metropolitan General Hospital, Athens, Not set
University General Hospital of Heraklion, Heraklion, Not set
University General Hospital of Patra, Patras, Not set
Euromedica General Clinic Thessaloniki, Thessaloniki, Not set
Orszagos Koranyi Pulmonologiai Intezet, Budapest, Not set
Orszagos Onkologiai Intezet, Budapest, Not set
Semmelweis Egyetem, Budapest, Not set
Orszagos Koranyi Pulmonologiai Intezet, Budapest, Not set
Csongrad Megyei Mellkasi Betegsegek Szakkorhaza, Deszk, Not set
Petz Aladar Megyei Oktato Korhaz, Györ, Not set
Borsod-Abauj-Zemplen Megyei Kozponti Korhaz es Egyetemi Oktatokorhaz, Miskolc, Not set
SzSzB Megyei Korhazak es Egyetemi Oktatokorhaz, Nyiregyhaza, Not set
Tolna Megyei Balassa Janos Korhaz, Szekszard, Not set
Tudogyogyintezet Torokbalint, Torokbalint, Not set
Zala Megyei Szent Rafael Korhaz, Zalaegerszeg, Not set
Cork University Hospital, Cork, Not set
Soroka University Medical Center, Beer Sheva, Not set
Rambam Health Care Center, Haifa, Not set
Hadassah University Hospital - Ein Kerem, Jerusalem, Not set
Sapir Medical Center, Meir Hospital, Kfar-Saba, Not set
Rabin Medical Center-Beilinson Campus, Petach Tikva, Not set
Chaim Sheba Medical Center, Ramat Gan, Not set
Kaplan Medical Center, Rechovot, Not set
Assaf Harofeh, Rishon Lezion, Not set
Tel Aviv Sourasky Medical Center, Tel Aviv, Not set
Ospedale Mater Salutis, Legnago, Verona
Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Not set
Presidio Ospedaliero Garibaldi Nesima, Catania, Not set
Azienda Ospedaliero Universitaria San Martino, Genova, Not set
Seconda Università degli Studi di Napoli, Napoli, Not set
Azienda Ospedaliero Universitaria di Parma, Parma, Not set
Azienda Ospedaliero Universitaria Pisana, Pisa, Not set
National Cancer Center Hospital East, Kashiwa-shi, Chiba-Ken
Kurume University Hospital, Kurume-shi, Fukuoka-Ken
NHO Hokkaido Cancer Center, Sapporo-shi, Hokkaido
Institute of Biomedical Research and Innovation Hospital, Kobe-shi, Hyogo-Ken
Kobe City Hospital Organization Kobe City Medical Center General Hospital, Kobe-shi, Hyogo-Ken
Yokohama Municipal Citizen's Hospital, Yokohama-shi, Kanagawa-Ken
Kanagawa Cancer Center, Yokohama-shi, Kanagawa-Ken
Kansai Medical University Hospital, Hirakata-shi, Osaka-Fu
Osaka Medical College Hospital, Takatsuki-shi, Osaka-Fu
National Cancer Center Hospital, Chuo-ku, Tokyo-To
Tokyo Medical University Hospital, Shinjuku-ku, Tokyo-To
Toyama University Hospital, Toyama-shi, Toyama-Ken
Kobe City Hospital Organization Kobe City Medical Center General Hospital, Kobe-shi, Not set
Chungbuk National University Hospital, Cheongju-si, Chungcheongbuk-do
Yonsei University Wonju Severance Christian Hospital, Wonju-si, Gangwon-do
Inje University Haeundae Paik Hospital, Busan, Gyeonggi-do
National Cancer Center, Goyang-si, Gyeonggi-do
CHA Bundang Medical Center, CHA University, Seongnam-si, Gyeonggi-do
Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do
The Catholic University of Korea, St. Vincent's Hospital, Suwon-si, Gyeonggi-do
Ajou University Hospital, Suwon-si, Gyeonggi-do
Kyungpook National University Chilgok Hospital, Daegu, Not set
Gachon University Gil Medical Center, Incheon, Not set
Korea University Anam Hospital, Seoul, Not set
Seoul National University Hospital, Seoul, Not set
Severance Hospital, Yonsei University, Seoul, Not set
Asan Medical Center, Seoul, Not set
Samsung Medical Center, Seoul, Not set
The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Not set
The Catholic University of Korea, Yeouido St. Mary's Hospital, Seoul, Not set
Korea University Guro Hospital, Seoul, Not set
Ulsan University Hospital, Ulsan, Not set
American University of Beirut Medical Center, Beirut, Not set
Rafik Hariri University Hospital, Beirut, Not set
Hotel Dieu de France Hospital, Beirut, Not set
Mount Lebanon Hospital, Beirut, Not set
Hammoud Hospital University Medical Center, Saida, Not set
Hospital of Lithuanian University of Health Sciences Kaunas Clinics, Kaunas, Not set
Martini Ziekenhuis, Groningen, Not set
Westfriesgasthuis - PARENT, Hoorn, Not set
ETZ Elisabeth, Tilburg, Not set
Auckland City Hospital, Auckland, Not set
Dunedin Public Hospital, Dunedin, Not set
Waikato Hospital, Hamilton, Not set
Palmerston North Hospital, Palmerston North, Not set
Tauranga Hospital, Tauranga, Not set
Wellington Hospital, Wellington, Not set
Instituto Nacional de Enfermedades Neoplásicas, Lima, Not set
Clinica Internacional Sede San Borja, Lima, Not set
Oncosalud, Lima, Not set
Centrum Terapii Wspolczesnej J.M. Jasnorzewska sp. komandytowo-akcyjna, Lodz, Not set
Instytut MSF Sp. o.o, Lodz, Not set
Wojewódzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Łodzi, Lodz, Not set
KO-MED Centra Kliniczne Lublin II, Lublin, Not set
SSZZOZ im. Dr Teodora Dunina w Rudce, Mrozy, Not set
SP Zespol Gruzlicy i Chorob Pluc w Olsztynie, Olsztyn, Not set
Mazowieckie Centrum Leczenia Chorob Pluc i Gruzlicy, Otwock, Not set
Szpital Kliniczny Przemienienia Panskiego Uniwersytetu Medycznego im. Karola Marcinkowskiego, Poznan, Not set
Izerskie Centrum Pulmonologii i Chemioterapii "IZER-MED" Spolka z o.o., Szklarska Poręba, Not set
Centrum Onkologii-Instytut im. M. Sklodowskiej Curie, Warszawa, Not set
Mazowiecki Szpital Onkologiczny, Wieliszew, Not set
Hospital Garcia de Orta, EPE, Almada, Not set
Hospital Professor Doutor Fernando Fonseca, E.P.E., Amadora-Lisbon, Not set
Centro Hospitalar De Coimbra-CHUC, Coimbra, Not set
Centro Hospitalar e Universitário de Coimbra, E.P.E (CHC), Coimbra, Not set
Centro Hospitalar de Lisboa Norte, E.P.E. - Hospital Pulido Valente, Lisboa, Not set
Centro Hospitalar de Lisboa Central, E.P.E. - Hospital de Santo António dos Capuchos, Lisboa, Not set
Centro Hospitalar do Porto, E.P.E. - Hospital de Santo António, Porto, Not set
Hospital CUF Porto, Porto, Not set
Instituto Português de Oncologia do Porto Francisco Gentil, EPE, Porto, Not set
Centro Hospitalar de São João, E.P.E., Porto, Not set
Centro Hospitalar de Entre o Douro e Vouga, E.P.E - Hospital de São Sebastião, Santa Maria da Feira, Not set
Centro Hospitalar Vila Nova de Gaia/Espinho, E.P.E, Vila Nova de Gaia, Not set
Spitalul Judetean de Urgenta "Dr. Constantin Opris" Baia Mare, Baia Mare, Not set
S.C Policlinica de Diagnostic Rapid S.A, Brasov, Not set
Institutul Oncologic "Prof. Dr. Al. Trestioreanu", Bucuresti, Not set
Spitalul Clinic Coltea, Bucuresti, Not set
S.C Gral Medical S.R.L, Bucuresti, Not set
Institutul Oncologic "Prof. Dr. Ion Chiricuta" Cluj Napoca, Cluj Napoca, Not set
S.C Medisprof S.R.L, Cluj-Napoca, Not set
Spitalul Militar de Urgenta "Dr.Constantin Papilian"Cluj -Napoca, Cluj-Napoca, Not set
S.C Radiotherapy Center Cluj S.R.L, Comuna Floresti, Not set
Spitalul Clinic Judetean de Urgenta "Sf. Apostol Andrei" Constanta, Constanta, Not set
S.C Centrul de Oncologie Sf. Nectarie S.R.L, Craiova, Not set
Institutul Regional de Oncologie Iasi, Iasi, Not set
S.C Pelican Impex S.R.L, Oradea, Not set
Spitalul Clinic Municipal "Dr. Gavril Curteanu" Oradea, Oradea, Not set
Spitalul Judetean de Urgenta "Sf. Ioan cel Nou" Suceava, Suceava, Not set
S.C Oncocenter Oncologie Clinica S.R.L, Timisoara, Not set
S.C Oncomed S.R.L, Timisoara, Not set
SBIH of Arkhangelsk region "Arkhangelsk Clinical Oncological Dispensary", Arkhangelsk, Not set
LLC Evimed, Chelyabinsk, Not set
Chelyabinsk Regional Oncology Dispensary, Chelyabinsk, Not set
Irkutsk Regional Oncology Dispensary, Irkutsk, Not set
RBIH "Ivanovo Regional Oncological Dispensary", Ivanovo, Not set
SBHI of Kaluga Region "Kaluga regional clinical oncology dispensary", Kaluga, Not set
SAIH "Republican Clinical Oncological Dispensary of the Ministry of Healthcare of Republic Tatarstan, Kazan, Not set
Kemerovo SPI Regional Clinical Oncology Dispensary, Kemerovo, Not set
SBHI "Krasnoyarsk Regional Oncology Dispensary n.a. A.I. Kryzhanovsky", Krasnoyarsk, Not set
RBIH "Kursk regional clinical oncology dispensary" of Kursk Region Healthcare Committee, Kursk, Not set
FSBSI "Russian Oncological Scientific Center n.a. N.N. Blokhin", Moscow, Not set
Murmansk Regional Clinical Hospital named after Bayandin, Murmansk, Not set
SBHI of Novosibirsk region "Novosibirsk Regional Oncological Dispensary", Novosibirsk, Not set
SBIH of Stavropol territory "Pyatigorsk Oncological Dispensary", Pyatigorsk, Not set
SBIH "Leningrad Regional Oncological Dispensary", Saint-Petersburg, Not set
"Bio Eq" LLC, Saint-Petersburg, Not set
FBI "Scientific Research Institute of Oncology n. a. N. N. Petrov", Saint-Petersburg, Not set
SBIH "Samara Regional Clinical Oncological Dispensary", Samara, Not set
SBIH "Oncological Dispensary # 2" of the MoH of Krasnodar territory, Sochi, Not set
FSBHI Clinical research institute of phthisiopulmonology, St. Petersburg, Not set
Tomsk Research Instutite of Oncology, Tomsk, Not set
BHI of Omsk region "Clinical Oncology Dispensary", Tomsk, Not set
Medicinskiy gorod, Tyumen, Not set
SBIH of Yaroslavl region "Regional Clinical Oncological Hospital", Yaroslavl, Not set
Clinical Center of Serbia, Belgrade, Not set
Institute of Oncology and Radiology of Serbia, Belgrade, Not set
Military Medical Academy, Belgrade, Not set
Clinical Center Bezanijska Kosa, Belgrade, Not set
Clinical Center Nis, Pulmonary Diseases Clinic, Gornji Matejevac, Not set
Clinical Center Kragujevac, Kragujevac, Not set
Institute for Pulmonary Diseases of Vojvodina, Sremska Kamenica, Not set
National University Cancer Institute, Singapore, Not set
National Cancer Centre, Singapore, Not set
Tan Tock Seng Hospital, Singapore, Not set
Nemocnica s poliklinikou Sv. Jakuba, n.o. Bardejov, Bardejov, Not set
Univerzitna nemocnica Bratislava, Nemocnica Ruzinov, Bratislava, Not set
Emery Clinical Services, Alberton, Gauteng
University of Pretoria Oncology Department, Pretoria, Gauteng
Johese Clinical Research, Pretoria, Gauteng
Cape Town Oncology Trials Pty Ltd, Cape Town, Western Cape
Hospital de Mataro, Mataro, Barcelona
Hospital Universitario Mutua de Terrassa, Terrassa, Barcelona
Hospital Universitario Donostia, San Sebastian, Guipuzcoa
Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, La Coruña
Complejo Hospitalario Universitario de Vigo, Vigo, Pontevedra
Specialist, Barcelona, Not set
Hospital Universitari Quiron Dexeus, Barcelona, Not set
Hospital Universitari Vall d'Hebron, Barcelona, Not set
Hospital de la Santa Creu i Sant Pau, Barcelona, Not set
ICO Girona - Hospital Universitari de Girona Dr. Josep Trueta, Girona, Not set
Hospital General Universitario Gregorio Marañon, Madrid, Not set
MD Anderson Cancer Centre, Madrid, Not set
Fundacion Jimenez Diaz, Madrid, Not set
Hospital Universitario La Paz, Madrid, Not set
Hospital Regional Universitario de Malaga, Málaga, Not set
Hospital Quiron Sagrado Corazon, Sevilla, Not set
Hospital Universitario Virgen del Rocio, Sevilla, Not set
Hospital Txagorritxu, Vitoria, Not set
Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Not set
China Medical University Hospital, Taichung, Not set
Taichung Veterans General Hospital, Taichung, Not set
National Taiwan University Hospital, Taipei, Not set
Taipei Veterans General Hospital, Taipei, Not set
Tri-Service General Hospital, Taipei, Not set
Chang Gung Memorial Hospital, Linkou, Taoyuan County, Not set
King Chulalongkorn Memorial Hospital, Patumwan, Bangkok
Rajavithi Hospital, Rajathevee, Bangkok
Maharaj Nakorn Chiang Mai Hospital, Muang, Chiang Mai
Srinagarind Hospital, Muang, Khon Kaen
Naresuan University Hospital, Muang, Phitsanulok
Songklanagarind Hospital, Hat Yai, Songkhla
Siriraj Hospital, Bangkok, Not set
Acibadem Adana Hospital, Adana, Not set
Baskent University Adana Application and Research Center, Adana, Not set
Adana Numune Training and Research Hospital, Adana, Not set
Cukurova University Medical Faculty, Adana, Not set
Adana City Hospital, Adana, Not set
Ankara University Medical Faculty, Ankara, Not set
Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Not set
Hacettepe University Medical Faculty, Ankara, Not set
Memorial Antalya Hastanesi, Antalya, Not set
Okmeydani Research and Training Hospital, Istanbul, Not set
Istanbul University Cerrahpasa Medical Faculty, Istanbul, Not set
Bakirkoy Dr. Sadi Konuk Teaching and Research Hospital, Istanbul, Not set
Medipol University Medical Faculty, Istanbul, Not set
Kartal Lutfi Kirdar Research and Training Hospital, Istanbul, Not set
Ege University Medical Faculty, Izmir, Not set
Inonu Uni. Med. Fac., Malatya, Not set
Mersin University Medical Faculty, Mersin, Not set
Sakarya Traning and Research Hospital, Sakarya, Not set
Namik Kemal University, Tekirdag, Not set
CI Chernivtsi RC Oncological Dispensary Bukovinian SMU Ch of Oncology and Radiology, Chernivtsi, Not set
CI Dnipropetrovsk CMCH #4 of Dnipropetrovsk RC Dept of Chemotherapy SI Dnipropetrovsk MA of MOHU, Dnipro, Not set
CI Transcarpathian Cl Onc Center Dep of Surgery#1 SHEI Ivano-Frankivsk NMU, Ivano-Frankivsk, Not set
SI S.P.Grygoriev Institute of Medical Radiology of NAMSU, Kharkiv, Not set
Communal Non-profit Enterprise Regional Center of Oncology, Kharkiv, Not set
Kherson Regional Oncologic Dispensary, Kherson, Not set
Treatment-Diagnostic Center of Private Enterprise of PPC Atsynus, Kropyvnytskyi, Not set
CI Kryvyi Rih Oncological Dispensary of DRC, Kryvyi Rih, Dnipropetrovsk Region, Not set
Kyiv City Clinical Oncological Center, Kyiv, Not set
Treatment-Prevention Institution Volyn Regional Oncological Dispensary, Lutsk, Not set
Lviv State Oncological Regional Treatment and Diagnostic Center, Lviv, Not set
Odesa Regional Oncologic Dispensary, Odesa, Not set
RCI Sumy Regional Clinical Oncological Dispensary, Sumy, Not set
CCCH City Oncological Center SHEI Uzhgorod NU, Uzhgorod, Not set
Podilskyi Regional Oncological Center, Vinnytsia, Not set
Vinnytsia Regional Clinical Oncological Dispensary, Vinnytsia, Not set
Southend University Hospital, Westcliff on Sea, Essex
Cheltenham General Hospital, Cheltenham, Gloucestershire
Chelsea and Westminster Hospital, London, Greater London
Mount Vernon Hospital, Stevenage, Hertfordshire
The Clatterbridge Cancer Centre, Wirral, Merseyside
Royal Stoke University Hospital, Stoke on Trent, Staffordshire
Conditions: First Line Non-Small Cell Lung Cancer
A Neoadjuvant Study of Nivolumab Plus Ipilimumab or Nivolumab Plus Chemotherapy Versus Chemotherapy Alone in Early Stage Non-Small Cell Lung Cancer (NSCLC)
Completed
The purpose of this neoadjuvant study is to compare nivolumab plus chemotherapy and chemotherapy alone in terms of safety and effectiveness, and to describe nivolumab plus ipilimumab's safety and effectiveness in treating resectable NSCLC.
This study has multiple primary endpoints.
The purpose of this neoadjuvant study is to compare nivolumab plus chemotherapy and chemotherapy alone in terms of safety and effectiveness, and to describe nivolumab plus ipilimumab's safety and effectiveness in treating resectable NSCLC.
This study has multiple primary endpoints. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/13/2025
Locations: Local Institution - 0121, Glendale, Arizona +139 locations
Local Institution - 0121, Glendale, Arizona
Local Institution - 0081, Los Angeles, California
Local Institution - 0025, Denver, Colorado
Local Institution - 0007, Plainville, Connecticut
Local Institution - 0173, Hollywood, Florida
Local Institution - 0136, Miami, Florida
Local Institution - 0054, Orlando, Florida
Orlando Health, Inc., Orlando, Florida
Indian River Medical Center, Vero Beach, Florida
Northwest Georgia Oncology Center, P.C., Marietta, Georgia
Local Institution - 0015, Chicago, Illinois
Local Institution - 0002, Chicago, Illinois
Illinois Cancer Specialists, Niles, Illinois
Local Institution - 0171, Fort Wayne, Indiana
Local Institution - 0170, Lexington, Kentucky
Local Institution - 0186, Louisville, Kentucky
University Medical Center New Orleans, New Orleans, Louisiana
Local Institution - 0151, Baltimore, Maryland
Local Institution - 0001, Baltimore, Maryland
Local Institution - 0008, Boston, Massachusetts
Southcoast Center For Cancer, Fairhaven, Massachusetts
Local Institution - 0006, Newton, Massachusetts
Local Institution - 0012, Detroit, Michigan
Local Institution - 0090, Hattiesburg, Mississippi
St Vincent Frontier Cancer Center, Billings, Montana
Local Institution - 0032, Las Vegas, Nevada
Local Institution - 0009, Hackensack, New Jersey
Valley Hospital Luckow Pavili, Westwood, New Jersey
Local Institution - 0027, Albany, New York
Local Institution - 0011, New York, New York
Local Institution - 0140, High Point, North Carolina
Christ Hospital, Cincinnati, Ohio
MetroHealth Medical Center, Cleveland, Ohio
Local Institution - 0149, Zanesville, Ohio
Kaiser Permanente, Portland, Oregon
Local Institution - 0139, Portland, Oregon
Local Institution - 0010, Philadelphia, Pennsylvania
Local Institution - 0018, Pittsburgh, Pennsylvania
Local Institution - 0013, Charleston, South Carolina
Local Institution - 0021, Charleston, South Carolina
Local Institution - 0146, Greenville, South Carolina
Local Institution - 0092, Nashville, Tennessee
Local Institution - 0005, Nashville, Tennessee
Local Institution - 0035, Austin, Texas
Texas Oncology, Bedford, Texas
Local Institution - 0153, Fort Bliss, Texas
Local Institution - 0106, Houston, Texas
Southwest Cancer Center, Lubbock, Texas
Texas Cancer Center - Sherman, Sherman, Texas
Local Institution - 0143, Tyler, Texas
Local Institution - 0026, Waco, Texas
Intermountain Medical Center, Murray, Utah
Southwest Regional Cancer Clinic, Saint George, Utah
Local Institution - 0003, Salt Lake City, Utah
Local Institution - 0135, Burlington, Vermont
Local Institution - 0125, Fairfax, Virginia
Local Institution - 0198, Fredericksburg, Virginia
Local Institution - 0022, Capital Federal, Buenos Aires
Local Institution - 0023, Ciudad Autonoma De Buenos Aire, Buenos Aires
Local Institution - 0079, Brasilia, Distrito Federal
Local Institution - 0077, Belo Horizonte, Minas Gerais
Local Institution - 0076, Ijui, RIO Grande DO SUL
Local Institution - 0073, Porto Alegre, RIO Grande DO SUL
Fundacao Pio Xii Hosp Cancer De Barretos, Barretos, Sao Paulo
Local Institution - 0075, Rio de Janeiro, Not set
Local Institution - 0095, Gatineau, Quebec
Local Institution - 0138, Montreal, Quebec
Local Institution - 0017, Montreal, Quebec
Local Institution - 0052, Trois-Rivieres, Quebec
Local Institution - 0016, Saskatoon, Saskatchewan
Local Institution - 0161, Beijing, Beijing
Local Institution, Beijing, Beijing
Local Institution - 0156, Beijing, Beijing
Local Institution - 0190, Guangzhou, Guangdong
Local Institution - 0192, Changsha, Hunan
Local Institution - 0175, Changsha, Hunan
Local Institution - 0193, Changsha, Hunan
Local Institution - 0179, Nanchang, Jiangxi
Local Institution - 0166, Nanchang, Jiangxi
Local Institution, Changchun, Jilin
Local Institution - 0159, XiAn, Shan1xi
Local Institution - 0180, Xian, Shan3xi
Local Institution - 0160, Shanghai, Shanghai
Local Institution - 0178, Chengdu, Sichuan
Local Institution - 0163, Tianjin, Tianjin
Local Institution - 0189, Hangzhou, Zhejiang
Local Institution - 0183, Hangzhou, Zhejiang
Local Institution - 0182, Hangzhou, Zhejiang
Local Institution - 0165, Shanghai, Not set
Local Institution - 0059, Marseille Cedex 20, Not set
Local Institution - 0112, Paris Cedex 5, Not set
Local Institution - 0060, Paris, Not set
Local Institution - 0064, Pierre Benite Cedax, Not set
Local Institution - 0061, Rennes Cedex 9, Not set
Local Institution - 0113, Strasbourg, Not set
Local Institution - 0058, Toulouse, Not set
Local Institution - 0062, Tours Cedex 09, Not set
Local Institution - 0019, Athens, Not set
Local Institution - 0122, Thessaloniki, Not set
Local Institution, Budapest, Not set
Local Institution, Szekesfehervar, Not set
Local Institution - 0068, Bari, Not set
Local Institution - 0080, Genova, Not set
Local Institution - 0070, Perugia, Not set
Local Institution - 0066, Ravenna, Not set
Local Institution - 0067, Roma, Not set
Local Institution - 0131, Nagoya-shi, Aichi
Local Institution - 0118, Kashiwa-shi, Chiba
Local Institution - 0111, Kitakyushu-shi, Fukuoka
Local Institution - 0110, Fukushima-shi, Fukushima
Local Institution - 0109, Hiroshima-Shi, Hiroshima
Local Institution - 0147, Sapporo-shi, Hokkaido
Local Institution - 0133, Kobe-shi, Hyogo
Local Institution - 0123, Yokohama-shi, Kanagawa
Local Institution - 0148, Sendai-shi, Miyagi
Local Institution - 0127, Osaka-shi, Osaka
Local Institution - 0119, Sakai-shi, Osaka
Local Institution - 0132, Sunto-gun, Shizuoka
Local Institution - 0126, Bunkyo-ku, Tokyo
Local Institution - 0120, Shinjuku-ku, Tokyo
Local Institution - 0108, Osaka, Not set
Local Institution - 0124, Tokyo, Not set
Local Institution - 0097, Busan, Not set
Local Institution - 0098, Hwasun, Not set
Local Institution - 0105, Seoul, Not set
Local Institution - 0042, Amsterdam, Not set
Local Institution - 0043, Groningen, Not set
Local Institution - 0050, Craiova, Not set
Local Institution - 0051, Romania, Not set
Local Institution - 0069, Sector 2, Not set
Local Institution - 0028, Barcelona, Not set
Local Institution - 0029, Madrid, Not set
Local Institution - 0031, Majadahonda - Madrid, Not set
Local Institution - 0102, New Taipei City, Not set
Local Institution - 0107, Taichung, Not set
Local Institution - 0099, Taipei, Not set
Local Institution - 0100, Taipei, Not set
Local Institution - 0093, Adana, Not set
Local Institution - 0084, Ankara, Not set
Local Institution - 0115, Istanbul, Not set
Conditions: Non Small Cell Lung Cancer
Savolitinib Plus Osimertinib Versus Platinum-based Doublet Chemotherapy in Participants With Non-Small Cell Lung Cancer Who Have Progressed on Osimertinib Treatment
Recruiting
Clinical study to investigate the efficacy and safety of savolitinib in combination with osimertinib versus platinum-based doublet chemotherapy in participants with EGFR mutated, MET-overexpressed and/or amplified, locally advanced or metastatic NSCLC who have progressed on treatment with Osimertinib.
Clinical study to investigate the efficacy and safety of savolitinib in combination with osimertinib versus platinum-based doublet chemotherapy in participants with EGFR mutated, MET-overexpressed and/or amplified, locally advanced or metastatic NSCLC who have progressed on treatment with Osimertinib. Read Less
Gender:
ALL
Ages:
Between 18 years and 130 years
Trial Updated:
01/09/2025
Locations: Research Site, La Jolla, California +284 locations
Research Site, La Jolla, California
Research Site, Orange City, Florida
Research Site, Orlando, Florida
Research Site, Honolulu, Hawaii
Research Site, Evergreen Park, Illinois
Research Site, Boston, Massachusetts
Research Site, Boston, Massachusetts
Research Site, Detroit, Michigan
Research Site, Florham Park, New Jersey
Research Site, New Brunswick, New Jersey
Research Site, New York, New York
Research Site, Canton, Ohio
Research Site, Nashville, Tennessee
Research Site, Berazategui, Not set
Research Site, Buenos Aires, Not set
Research Site, Caba, Not set
Research Site, Cordoba, Not set
Research Site, Florida, Not set
Research Site, La Rioja, Not set
Research Site, Rosario, Not set
Research Site, Rosario, Not set
Research Site, San Miguel de Tucumán, Not set
Research Site, Viedma, Not set
Research Site, Clayton, Not set
Research Site, Fremantle, Not set
Research Site, Geelong, Not set
Research Site, Liverpool, Not set
Research Site, Southport, Not set
Research Site, Waratah NSW, Not set
Research Site, Westmead, Not set
Research Site, Graz, Not set
Research Site, Salzburg, Not set
Research Site, Wien, Not set
Research Site, Bruxelles, Not set
Research Site, Bruxelles, Not set
Research Site, Edegem, Not set
Research Site, Gent, Not set
Research Site, Hasselt, Not set
Research Site, Mons, Not set
Research Site, Roeselare, Not set
Research Site, Sint-Niklaas, Not set
Research Site, Belo Horizonte, Not set
Research Site, Brasilia, Not set
Research Site, Cachoeiro de Itapemirim, Not set
Research Site, Curitiba, Not set
Research Site, Ijuí, Not set
Research Site, Ipatinga, Not set
Research Site, Porto Alegre, Not set
Research Site, Porto Alegre, Not set
Research Site, Porto Alegre, Not set
Research Site, Rio De Janeiro, Not set
Research Site, Rio De Janeiro, Not set
Research Site, Salvador, Not set
Research Site, Salvador, Not set
Research Site, São Paulo, Not set
Research Site, São Paulo, Not set
Research Site, São Paulo, Not set
Research Site, Vitória, Not set
Research Site, Haskovo, Not set
Research Site, Pleven, Not set
Research Site, Plovdiv, Not set
Research Site, Sofia, Not set
Research Site, Varna, Not set
Research Site, Vratsa, Not set
Research Site, Calgary, Alberta
Research Site, Mississauga, Ontario
Research Site, Toronto, Ontario
Research Site, Toronto, Ontario
Research Site, Montreal, Quebec
Research Site, Montreal, Quebec
Research Site, Santiago, Not set
Research Site, Santiago, Not set
Research Site, Temuco, Not set
Research Site, Baoding, Not set
Research Site, Beijing, Not set
Research Site, Beijing, Not set
Research Site, Bengbu, Not set
Research Site, Changchun, Not set
Research Site, Changsha, Not set
Research Site, Changsha, Not set
Research Site, Changsha, Not set
Research Site, Chengdu, Not set
Research Site, Chongqing, Not set
Research Site, Fuzhou, Not set
Research Site, Fuzhou, Not set
Research Site, Hangzhou, Not set
Research Site, Hankou,Wuhan, Not set
Research Site, Harbin, Not set
Research Site, Hefei, Not set
Research Site, Jinan, Not set
Research Site, Linyi, Not set
Research Site, Nanchang, Not set
Research Site, Qingdao, Not set
Research Site, Shanghai, Not set
Research Site, Shenyang, Not set
Research Site, Shenzhen, Not set
Research Site, Wuhan, Not set
Research Site, Xi'an, Not set
Research Site, Xiangfan, Not set
Research Site, Xian, Not set
Research Site, Yichang, Not set
Research Site, Zhengzhou, Not set
Research Site, Angers, Not set
Research Site, Bobigny, Not set
Research Site, Bordeaux Cedex, Not set
Research Site, Brest, Not set
Research Site, Creteil, Not set
Research Site, Dijon, Not set
Research Site, Marseille, Not set
Research Site, Montpellier, Not set
Research Site, Paris, Not set
Research Site, Paris, Not set
Research Site, Poitiers, Not set
Research Site, Rennes, Not set
Research Site, Rouen, Not set
Research Site, Saint-Herblain, Not set
Research Site, Saint-Quentin, Not set
Research Site, Strasbourg Cedex, Not set
Research Site, Suresnes Cedex, Not set
Research Site, Berlin, Not set
Research Site, Berlin, Not set
Research Site, Chemnitz, Not set
Research Site, Frankfurt A. Main, Not set
Research Site, Gauting, Not set
Research Site, Homburg, Not set
Research Site, Immenhausen, Not set
Research Site, Löwenstein, Not set
Research Site, Muenster, Not set
Research Site, München, Not set
Research Site, Stuttgart, Not set
Research Site, Wangen, Not set
Research Site, Athens, Not set
Research Site, Athens, Not set
Research Site, Chaidari, Not set
Research Site, Heraklion, Not set
Research Site, Larissa, Not set
Research Site, Rio, Not set
Research Site, Thessaloniki, Not set
Research Site, Thessaloniki, Not set
Research Site, HKG, Not set
Research Site, Hong Kong, Not set
Research Site, Kowloon, Not set
Research Site, Afula, Not set
Research Site, Ashdod, Not set
Research Site, Be'er Ya'akov, Not set
Research Site, Hadera, Not set
Research Site, Jerusalem, Not set
Research Site, Tel Aviv, Not set
Research Site, Avellino, Not set
Research Site, Aviano, Not set
Research Site, Catania, Not set
Research Site, Meldola, Not set
Research Site, Milano, Not set
Research Site, Milan, Not set
Research Site, Modena, Not set
Research Site, Monserrato, Not set
Research Site, Napoli, Not set
Research Site, Orbassano, Not set
Research Site, Padova, Not set
Research Site, Parma, Not set
Research Site, Perugia, Not set
Research Site, Peschiera Del Garda, Not set
Research Site, Roma, Not set
Research Site, Roma, Not set
Research Site, Treviso, Not set
Research Site, Bunkyo-ku, Not set
Research Site, Chuo-ku, Not set
Research Site, Fukuoka-shi, Not set
Research Site, Hirosaki-shi, Not set
Research Site, Hiroshima-shi, Not set
Research Site, Iwakuni-shi, Not set
Research Site, Kanazawa-shi, Not set
Research Site, Kashiwa, Not set
Research Site, Kobe-shi, Not set
Research Site, Kobe, Not set
Research Site, Kumamoto-shi, Not set
Research Site, Kurume-shi, Not set
Research Site, Matsuyama, Not set
Research Site, Nagasaki-shi, Not set
Research Site, Okayama-shi, Not set
Research Site, Osaka-shi, Not set
Research Site, Osakasayama-shi, Not set
Research Site, Sakai-shi, Not set
Research Site, Sapporo-shi, Not set
Research Site, Sapporo-shi, Not set
Research Site, Sendai-shi, Not set
Research Site, Sunto-gun, Not set
Research Site, Utsunomiya-shi, Not set
Research Site, Wakayama-shi, Not set
Research Site, Yokohama-shi, Not set
Research Site, Goyang-si, Not set
Research Site, Gyeonggi-do, Not set
Research Site, Incheon, Not set
Research Site, Jinju-si, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Suwon, Not set
Research Site, Ulsan, Not set
Research Site, Kota Bharu, Not set
Research Site, Kuala Lumpur, Not set
Research Site, Petaling Jaya, Not set
Research Site, Pulau Pinang, Not set
Research Site, Sabah, Not set
Research Site, Amsterdam, Not set
Research Site, Bacolod, Not set
Research Site, Baguio City, Not set
Research Site, Cebu City, Not set
Research Site, Cebu, Not set
Research Site, Davao City, Not set
Research Site, Manila, Not set
Research Site, Quezon City, Not set
Research Site, Quezon City, Not set
Research Site, Quezon City, Not set
Research Site, San Juan, Not set
Research Site, Bialystok, Not set
Research Site, Krakow, Not set
Research Site, Olsztyn, Not set
Research Site, Łódź, Not set
Research Site, Chelyabinsk, Not set
Research Site, Moscow, Not set
Research Site, Saint Petersburg, Not set
Research Site, Tomsk, Not set
Research Site, Singapore, Not set
Research Site, Singapore, Not set
Research Site, Badajoz, Not set
Research Site, Badalona, Not set
Research Site, Barcelona, Not set
Research Site, Barcelona, Not set
Research Site, Cordoba, Not set
Research Site, Girona, Not set
Research Site, La Coruña, Not set
Research Site, Madrid, Not set
Research Site, Madrid, Not set
Research Site, Madrid, Not set
Research Site, Majadahonda, Not set
Research Site, Málaga, Not set
Research Site, Pontevedra, Not set
Research Site, Sabadell, Not set
Research Site, Sevilla, Not set
Research Site, Valencia, Not set
Research Site, Zaragoza, Not set
Research Site, Baden, Not set
Research Site, Basel, Not set
Research Site, Bern, Not set
Research Site, Winterthur, Not set
Research Site, Zürich, Not set
Research Site, Chiayi, Not set
Research Site, Hsinchu, Not set
Research Site, Kaohsiung City, Not set
Research Site, Liuying, Not set
Research Site, Taichung, Not set
Research Site, Taichung, Not set
Research Site, Taipei 112, Not set
Research Site, Taipei City, Not set
Research Site, Taipei, Not set
Research Site, Bangkok, Not set
Research Site, Bangkok, Not set
Research Site, Chiang Mai, Not set
Research Site, Dusit, Not set
Research Site, Hat Yai, Not set
Research Site, Muang, Not set
Research Site, Mueang Chanthaburi, Not set
Research Site, Adana, Not set
Research Site, Ankara, Not set
Research Site, Edirne, Not set
Research Site, Istanbul, Not set
Research Site, Istanbul, Not set
Research Site, Izmir, Not set
Research Site, Bristol, Not set
Research Site, Leicester, Not set
Research Site, Liverpool, Not set
Research Site, London, Not set
Research Site, Manchester, Not set
Research Site, Newport, Not set
Research Site, Reading, Not set
Research Site, Wolverhampton, Not set
Research Site, Can Tho, Not set
Research Site, Hanoi City, Not set
Research Site, Hanoi, Not set
Research Site, Hanoi, Not set
Research Site, Ho Chi Minh city, Not set
Research Site, Ho Chi Minh, Not set
Conditions: Carcinoma, Non-Small-Cell Lung
Study of Pembrolizumab (MK-3475) Plus Chemotherapy vs Placebo Plus Chemotherapy as Neoadjuvant Therapy and Pembrolizumab vs Placebo as Adjuvant Therapy in Participants With Triple Negative Breast Cancer (TNBC) (MK-3475-522/KEYNOTE-522)
Active Not Recruiting
The purpose of this study is to evaluate the efficacy and safety of pembrolizumab (MK-3475) plus chemotherapy vs placebo plus chemotherapy as neoadjuvant therapy and pembrolizumab vs placebo as adjuvant therapy in participants who have triple negative breast cancer (TNBC).
After a screening phase of approximately 28 days, each participant will receive neoadjuvant study treatment (Pembrolizumab + Chemotherapy OR Placebo + Chemotherapy) based on the randomization schedule for approximately 24 wee... Read More
The purpose of this study is to evaluate the efficacy and safety of pembrolizumab (MK-3475) plus chemotherapy vs placebo plus chemotherapy as neoadjuvant therapy and pembrolizumab vs placebo as adjuvant therapy in participants who have triple negative breast cancer (TNBC).
After a screening phase of approximately 28 days, each participant will receive neoadjuvant study treatment (Pembrolizumab + Chemotherapy OR Placebo + Chemotherapy) based on the randomization schedule for approximately 24 weeks (8 cycles). Each participant will then undergo definitive surgery 3-6 weeks after conclusion of the last cycle of the neoadjuvant study treatment. After definitive surgery, each participant will receive adjuvant study treatment (Pembrolizumab OR Placebo) for approximately 27 weeks (9 cycles). Following adjuvant study treatment, each participant will be monitored for safety, survival and disease recurrence.
The primary study hypothesis is that pembrolizumab is superior to placebo, in combination with chemotherapy, as measured by the rate of Pathological Complete Response (pCR) and/or Event-free Survival (EFS), in participants with locally advanced TNBC. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/08/2025
Locations: Virginia G. Piper Cancer Center Pharmacy - Scottsdale Healthcare ( Site 0089), Scottsdale, Arizona +192 locations
Virginia G. Piper Cancer Center Pharmacy - Scottsdale Healthcare ( Site 0089), Scottsdale, Arizona
Arizona Oncology Associates PC- HOPE ( Site 8001), Tucson, Arizona
Cedars Sinai Medical Center ( Site 0091), Los Angeles, California
Pacific Cancer Care ( Site 0069), Monterey, California
ICRI ( Site 0072), Whittier, California
University of Colorado Cancer Center ( Site 0021), Aurora, Colorado
Yale University School of Medicine ( Site 0054), New Haven, Connecticut
Christiana Hospital ( Site 0029), Newark, Delaware
Univ of Miami-Sylvester Comprehensive Cancer Center- Kendall satellite ( Site 0079), Miami, Florida
The University of Chicago Medical Center ( Site 0047), Chicago, Illinois
North Shore University Health System ( Site 0081), Evanston, Illinois
Orchard Healthcare Research Inc. ( Site 0049), Skokie, Illinois
Goshen Center for Cancer Care ( Site 0010), Goshen, Indiana
University of Iowa Hospital and Clinics ( Site 0038), Iowa City, Iowa
New England Cancer Specialists ( Site 0005), Scarborough, Maine
Henry Ford Hospital ( Site 0003), Detroit, Michigan
Minnesota Oncology Hematology, PA ( Site 8013), Minneapolis, Minnesota
Rutgers Cancer Institute of New Jersey ( Site 0073), New Brunswick, New Jersey
Broome Oncology, LLC ( Site 8002), Johnson City, New York
Nyack Hospital Infusion Center ( Site 0059), Nyack, New York
TriHealth Cancer Institute-Good Samaritan Hospital ( Site 0044), Cincinnati, Ohio
Oncology Hematology Care, Inc. ( Site 8011), Cincinnati, Ohio
Providence Portland Medical Center ( Site 0052), Portland, Oregon
Northwest Cancer Specialists, P.C. ( Site 8008), Portland, Oregon
Magee - Women's Hospital ( Site 0011), Pittsburgh, Pennsylvania
Rhode Island Hospital ( Site 0060), Providence, Rhode Island
The West Clinic, P.C. ( Site 0078), Germantown, Tennessee
Texas Oncology-Austin Central ( Site 8005), Austin, Texas
Parkland Health and Hospital System ( Site 0093), Dallas, Texas
Texas Oncology-Baylor Charles A. Sammons Cancer Center ( Site 8006), Dallas, Texas
Simmons Cancer Center ( Site 0094), Dallas, Texas
UT Southwestern Medical Center ( Site 0030), Dallas, Texas
Moncrief Cancer Institute ( Site 0092), Fort Worth, Texas
Texas Oncology-Memorial City ( Site 8003), Houston, Texas
Houston Methodist Cancer Center ( Site 0013), Houston, Texas
Texas Oncology- Plano East ( Site 8010), Plano, Texas
Texas Oncology-San Antonio Northeast ( Site 8012), San Antonio, Texas
Texas Oncology-Tyler ( Site 8007), Tyler, Texas
University of Virginia ( Site 0022), Charlottesville, Virginia
Virginia Cancer Specialists, PC ( Site 8009), Fairfax, Virginia
Bon Secours Cancer Institute Medical Oncology at St. Mary's ( Site 0033), Midlothian, Virginia
Peninsula Cancer Institute, LLC ( Site 0041), Newport News, Virginia
Virginia Oncology Associates ( Site 8000), Norfolk, Virginia
Kadlec Clinic Hematology and Oncology ( Site 0087), Kennewick, Washington
Seattle Cancer Care Alliance ( Site 0068), Seattle, Washington
Medical Oncology Associates (Summit Cancer Centers) ( Site 0014), Spokane, Washington
YVMH dba Vrigina Mason Memorial/North Star Lodge Cancer Center ( Site 8004), Yakima, Washington
Royal North Shore Hospital ( Site 2000), Sydney, New South Wales
Westmead Hospital ( Site 2002), Sydney, New South Wales
Royal Adelaide Hospital ( Site 2008), Adelaide, South Australia
Cabrini Health ( Site 2009), East Malvern, Victoria
Frankston Hospital ( Site 2010), Franskton, Not set
Royal Brisbane and Women s Hospital ( Site 2003), Herston, Not set
St John of God Subiaco Hospital ( Site 2006), Perth, Not set
Hospital Nossa Senhora da Conceicao ( Site 0203), Porto Alegre, Rio Grande Do Sul
UOPECCAN - Uniao Oeste Paranaense de Estudos e Combate ao Cancer ( Site 0206), Cascavel, Not set
Universidade de Caxias do Sul ( Site 0201), Caxias do Sul, Not set
Hospital Erasto Gaertner ( Site 0207), Curitiba, Not set
Instituto do Cancer do Ceara ( Site 0205), Fortaleza, Not set
Hospital Araujo Jorge ( Site 0204), Goiania, Not set
Hospital Sao Lucas da PUCRS ( Site 0200), Porto Alegre, Not set
Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto ( Site 0208), Sao Jose do Rio Preto, Not set
Instituto do Cancer de Sao Paulo - ICESP ( Site 0211), Sao Paulo, Not set
Tom Baker Cancer Centre ( Site 0105), Calgary, Alberta
The Ottawa Hospital - Cancer Care ( Site 0100), Ottawa, Ontario
Princess Margaret Cancer Centre ( Site 0103), Toronto, Ontario
Centre Hospitalier de l Universite de Montreal - CHUM ( Site 0106), Montreal, Quebec
Jewish General Hospital ( Site 0101), Montreal, Quebec
CIUSSS de l'Estrie-CHUS ( Site 0102), Sherbrooke, Quebec
CHU de Quebec Universite Laval - Hopital du Saint-Sacrement ( Site 0104), Quebec, Not set
Oncomedica S.A. ( Site 0404), Monteria, Cordoba
Oncologos del Occidente S.A. ( Site 0405), Pereira, Risaralda
Hospital Universitario San Ignacio ( Site 0401), Bogota, Not set
Instituto Nacional de Cancerologia [Bogota-Colombia] ( Site 0403), Bogota, Not set
Hemato Oncologos S.A. ( Site 0400), Cali, Not set
Instituto De Cancerologia S.A. ( Site 0406), Medellin, Not set
CHU Jean Minjoz ( Site 0917), Besancon, Not set
Polyclinique Bordeaux Nord Aquitaine ( Site 0911), Bordeaux, Not set
Centre Francois Baclesse ( Site 0907), Caen, Not set
Centre Jean Perrin ( Site 0903), Clermont-Ferrand Cedex 01, Not set
Clinique Victor Hugo ( Site 0901), Le Mans, Not set
Hopital prive du Confluent ( Site 0902), Nantes, Not set
Institut Curie ( Site 0909), Paris, Not set
Hopital Saint Louis ( Site 0908), Paris, Not set
Hopital Diaconesses Croix Saint Simon ( Site 0905), Paris, Not set
CHU de la Miletrie Poitiers ( Site 0913), Poitiers, Not set
Institut Claudius Regaud IUCT Oncopole ( Site 0914), Toulouse Cedex 9, Not set
HELIOS Klinikum Berlin-Buch ( Site 1005), Berlin, Not set
Gynaekologisches Zentrum ( Site 1004), Bonn, Not set
Universitaetsklinikum Erlangen ( Site 1001), Erlangen, Not set
Kliniken Essen Mitte ( Site 1012), Essen, Not set
Universitaetsklinik und Poliklinik Halle/Saale ( Site 1008), Halle, Not set
Universitaetsklinikum Hamburg-Eppendorf ( Site 1007), Hamburg, Not set
Klinikum der Universit. Muenchen ( Site 1002), Muenchen, Not set
Caritasklinik St. Theresia ( Site 1011), Saarbruecken, Not set
Universitaets-Frauenklinik Tuebingen ( Site 1003), Tubingen, Not set
Bon Secours Hospital ( Site 1551), Cork, Not set
St Vincents University Hospital ( Site 1550), Dublin, Not set
Oncology institute ( Site 1601), Beer Sheva, Not set
Assaf Harofeh MC ( Site 1605), Beer Yaakov-Zerifin, Not set
Hadassah Ein Karem - Sharett Institute of Oncology ( Site 1600), Jerusalem, Not set
Rabin-Medical Center ( Site 1604), Petah Tikva, Not set
Sheba Medical Center ( Site 1602), Ramat-Gan, Not set
Sourasky Medical Center ( Site 1603), Tel Aviv, Not set
Istituto Scientifico Romagnolo per Studio e Cura Tumori IRST ( Site 1101), Meldola, FC
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia ( Site 1103), Brescia, Not set
Ospedale San Luca, AZIENDA USL2 TOSCANA NORD OVEST ( Site 1105), Lucca, Not set
Ospedale Civile di Macerata ( Site 1104), Macerata, Not set
Istituto Europeo di Oncologia ( Site 1106), Milano, Not set
Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 1102), Napoli, Not set
Aichi Cancer Center Hospital ( Site 2502), Nagoya, Aichi
National Cancer Center Hospital East ( Site 2518), Kashiwa, Chiba
National Hospital Organization Hokkaido Cancer Center ( Site 2512), Sapporo, Hokkaido
Hyogo College of Medicine Hospital ( Site 2506), Nishinomiya, Hyogo
Tokai University Hospital ( Site 2517), Isehara, Kanagawa
St. Marianna University School of Medicine Hospital ( Site 2516), Kawasaki, Kanagawa
Kindai University Hospital ( Site 2507), Osakasayama, Osaka
Saitama Medical University International Medical Center ( Site 2513), Hidaka, Saitama
Saitama Cancer Center ( Site 2510), Kitaadachi-gun, Saitama
Shizuoka Cancer Center Hospital and Research Institute ( Site 2514), Sunto-gun, Shizuoka
Chiba Cancer Center ( Site 2519), Chiba, Not set
Hiroshima City Hiroshima Citizens Hospital ( Site 2501), Hiroshima, Not set
Social medical corporation Hakuaikai Sagara Hospital ( Site 2508), Kagoshima, Not set
Kumamoto University Hospital ( Site 2515), Kumamoto, Not set
National Hospital Organization Osaka National Hospital ( Site 2505), Osaka, Not set
National Cancer Center Hospital ( Site 2500), Tokyo, Not set
St.Luke's International Hospital ( Site 2511), Tokyo, Not set
Toranomon Hospital ( Site 2503), Tokyo, Not set
The Cancer Institute Hospital of JFCR ( Site 2509), Tokyo, Not set
Seoul National University Hospital ( Site 2101), Seoul, Not set
Severance Hospital Yonsei University Health System ( Site 2100), Seoul, Not set
Asan Medical Center ( Site 2102), Seoul, Not set
Samsung Medical Center ( Site 2103), Seoul, Not set
Mazowiecki Szpital Onkologiczny ( Site 1713), Wieliszew, Mazowieckie
Centrum Onkologii Instytut im. Marii Skłodowskiej Curie ( Site 1717), Gliwice, Slaskie
Centrum Onkologii im. Prof. Franciszka Lukaszczyka ( Site 1708), Bydgoszcz, Not set
Centrum Onkologii im. Prof. Franciszka Lukaszczyka ( Site 1712), Bydgoszcz, Not set
Szpital Morski im. PCK. Szpitale Pomorskie Sp. Z o.o ( Site 1701), Gdynia, Not set
Centrum Onkologii Instytut im. Marii Sklodowskiej Curie ( Site 1719), Krakow, Not set
Centrum Onkologii Ziemi Lubelskiej im. sw. Jana z Dukli ( Site 1700), Lublin, Not set
Dolnoslaskie Centrum Onkologii. ( Site 1702), Wroclaw, Not set
Fundacao Champalimaud ( Site 2444), Lisboa, Not set
Hospital de Santa Maria, E.P.E. ( Site 2445), Lisboa, Not set
Instituto Portugues de Oncologia Do Porto Francisco Gentil E.P.E. ( Site 2446), Porto, Not set
Arkhangelsk Clinical Oncological Dispensary ( Site 1810), Arkhangelsk, Not set
Chelyabinsk Regional Clinical Oncological Dispensary ( Site 1805), Chelyabinsk, Not set
Republican Clinical Oncology Dispensary of Tatarstan MoH ( Site 1806), Kazan, Not set
Russian Oncological Research Center n.a. N.N.Blokhin of MoH ( Site 1801), Moscow, Not set
GBU RO Regional Clinical Oncological Dispensary ( Site 1808), Ryazan, Not set
Scientific Research Oncology Institute n.a. N.N.Petrov ( Site 1803), Saint Petersburg, Not set
Republican Clinical Oncology Dispensary of Republic of Bashkortostan ( Site 1804), Ufa, Not set
National Cancer Centre Singapore ( Site 2600), Singapore, Not set
ICO L Hospitalet ( Site 1305), Hospitalet de Llobregat, Barcelona
Hospital Quiron de Madrid ( Site 1303), Pozuelo de Alarcon, Madrid
Hospital del Mar ( Site 1306), Barcelona, Not set
Instituto Oncologico Baselga.Hospital Quiron. ( Site 1312), Barcelona, Not set
Hospital General Universitari Vall d Hebron ( Site 1301), Barcelona, Not set
Hospital Universitario Reina Sofia ( Site 1304), Cordoba, Not set
Hospital Universitario Ramon y Cajal ( Site 1300), Madrid, Not set
Complejo Hospitalario Universitario de Santiago ( Site 1308), Santiago de Compostela, Not set
Hospital Universitario Virgen del Rocio ( Site 1314), Sevilla, Not set
Hospital Clinico Univ de Valencia ( Site 1313), Valencia, Not set
Linkopings Universitetssjukhus ( Site 1402), Linkoping, Not set
Karolinska Universitetssjukhuset Solna ( Site 1404), Solna, Not set
Norrlands Universitetssjukhus ( Site 1401), Umea, Not set
Akademiska Sjukhuset ( Site 1403), Uppsala, Not set
Taipei Veterans General Hospital ( Site 2302), Taipei, Beitou
National Cheng Kung University Hospital ( Site 2305), Tainan, Not set
National Taiwan University Hospital ( Site 2301), Taipei, Not set
MacKay Memorial Hospital ( Site 2303), Taipei, Not set
Koo Foundation Sun Yat-Sen Cancer Center ( Site 2304), Taipei, Not set
Linkou Chang Gung Memorial Hospital ( Site 2300), Taoyuan, Not set
Samsun Ondokuz Mayıs Universitesi Tıp Fakultesi Hastanesi ( Site 1910), Samsun, Atakum
Adana Acıbadem Hospital Department of Medical Oncology ( Site 1906), Adana, Not set
Baskent Unıversity Adana Kısla Hospital ( Site 1903), Adana, Not set
Hacettepe Universitesi Tip Fakultesi Hastanesi ( Site 1912), Ankara, Not set
Abdurrahman Yurtaslan Oncology Training and Research Hospital ( Site 1909), Ankara, Not set
Ozel Medicana International Ankara Hastanesi ( Site 1915), Ankara, Not set
Antalya Memorial Hospital Department of Medical Oncology ( Site 1908), Antalya, Not set
Trakya University Medical Faculty Balkan Oncology Hospital ( Site 1901), Edirne, Not set
Acibadem Altunizade Hastanesi ( Site 1900), Istambul, Not set
İstanbul University Cerrahpaşa Medical Faculty ( Site 1904), Istanbul, Not set
Amerikan Hospital Medical ( Site 1902), Istanbul, Not set
Memorial Sisli Hastanesi ( Site 1913), Istanbul, Not set
Ege University Medical Faculty Tulay Aktas Oncology Hospital ( Site 1905), Izmir, Not set
Izmir Medical Park Hospital Department of Medical Oncology ( Site 1907), Izmir, Not set
Colchester General Hospital ( Site 1508), Colchester, Essex
Barts Cancer Institute ( Site 1500), London, Not set
St George s Hospital ( Site 1516), London, Not set
Maidstone Hospital ( Site 1511), Maidstone, Not set
The James Cook University Hospital ( Site 1515), Middlesbrough, Not set
Nottingham University Hospitals NHS Trust ( Site 1505), Nottingham, Not set
Royal Cornwall Hospitals NHS Trust ( Site 1504), Truro, Not set
Conditions: Triple Negative Breast Neoplasms
A Study of Pembrolizumab (MK-3475) With or Without Maintenance Olaparib in First-line Metastatic Squamous Non-small Cell Lung Cancer (NSCLC, MK-7339-008/KEYLYNK-008)
Active Not Recruiting
The current study will compare pembrolizumab (MK-3475) plus maintenance olaparib, vs. pembrolizumab plus maintenance olaparib placebo for the treatment of squamous NSCLC. The study's 2 primary hypotheses are:
1. Pembrolizumab plus maintenance olaparib is superior to pembrolizumab plus maintenance olaparib placebo with respect to progression-free survival (PFS) per RECIST 1.1 by blinded independent clinical review (BICR).
2. Pembrolizumab plus maintenance olaparib is superior to pembrolizumab pl... Read More
The current study will compare pembrolizumab (MK-3475) plus maintenance olaparib, vs. pembrolizumab plus maintenance olaparib placebo for the treatment of squamous NSCLC. The study's 2 primary hypotheses are:
1. Pembrolizumab plus maintenance olaparib is superior to pembrolizumab plus maintenance olaparib placebo with respect to progression-free survival (PFS) per RECIST 1.1 by blinded independent clinical review (BICR).
2. Pembrolizumab plus maintenance olaparib is superior to pembrolizumab plus maintenance olaparib placebo with respect to overall survival (OS).
As of Amendment 07, there will be no further analyses for OS and patient-reported outcome assessments. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/06/2025
Locations: Alabama Oncology Bruno Cancer Center ( Site 0001), Birmingham, Alabama +177 locations
Alabama Oncology Bruno Cancer Center ( Site 0001), Birmingham, Alabama
Disney Family Cancer Center ( Site 0005), Burbank, California
Boca Raton Regional Hospital ( Site 0018), Boca Raton, Florida
Mid-Florida Cancer Centers ( Site 0022), Orange City, Florida
H. Lee Moffitt Cancer Center and Research Institute ( Site 0024), Tampa, Florida
Columbus Regional Research Institute ( Site 0099), Columbus, Georgia
Mount Sinai Hospital Medical Center ( Site 0035), Chicago, Illinois
Oncology of Northshore ( Site 0036), Rolling Meadows, Illinois
Methodists Hospitals/Premier Oncology Hematology Associates ( Site 0039), Merrillville, Indiana
MedStar Franklin Square Medical Center ( Site 0044), Baltimore, Maryland
Barbara Ann Karmanos Cancer Institute ( Site 0046), Detroit, Michigan
Hattiesburg Clinic ( Site 0051), Hattiesburg, Mississippi
Frontier Oncology ( Site 0052), Billings, Montana
Bozeman Health Deaconness Cancer Center ( Site 0053), Bozeman, Montana
Waverly Hematology Oncology ( Site 0054), Cary, North Carolina
Thompson Cancer Survival Center ( Site 2812), Knoxville, Tennessee
Renovatio Clinical ( Site 0074), The Woodlands, Texas
Cancer Care Northwest ( Site 0083), Spokane Valley, Washington
Hospital Italiano Regional del Sur ( Site 0509), Bahia Blanca, Buenos Aires
Instituto de Investigaciones Clinicas Mar del Plata ( Site 0516), Mar del Plata, Buenos Aires
Hospital Britanico de Buenos Aires ( Site 0500), Buenos Aires, Caba
Instituto Medico Rio Cuarto ( Site 0501), Rio Cuarto, Cordoba
Sanatorio Parque ( Site 0515), Rosario, Santa Fe
Centro Oncológico de Rosario ( Site 0507), Rosario, Santa Fe
Centro Medico San Roque ( Site 0506), San Miguel de Tucuman, Tucuman
Hospital Italiano de Buenos Aires ( Site 0511), Buenos Aires, Not set
Clínica Universitaria Reina Fabiola ( Site 0505), Cordoba, Not set
Sanatorio Privado San Geronimo S.R.L ( Site 0510), Santa Fe, Not set
Liverpool Hospital ( Site 1201), Liverpool, New South Wales
Southern Medical Day Care Centre ( Site 1200), Wollongong, New South Wales
Townsville General Hospital ( Site 1202), Townsville, Queensland
Monash Cancer Centre ( Site 1205), Clayton, Victoria
Ordensklinikum Linz GmbH Elisabethinen ( Site 1307), Linz, Oberosterreich
Klinikum Wels-Grieskirchen ( Site 1304), Wels, Oberosterreich
Innsbruck LKH ( Site 1302), Innsbruck, Tirol
Social Medical Center - Otto Wagner Hospital ( Site 1301), Vienna, Wien
Krankenhaus Nord - Klinik Floridsdorf ( Site 1300), Wien, Not set
Hospital Sao Rafael ( Site 0258), Salvador - BA, Bahia
Instituto do Cancer do Ceara ( Site 0251), Fortaleza, Ceara
Oncologica do Brasil ( Site 0256), Belem, Para
Hospital Tacchini ( Site 0265), Bento Goncalves, Rio Grande Do Sul
Irmandade da Santa Casa de Misericordia de Porto Alegre ( Site 0255), Porto Alegre, Rio Grande Do Sul
Centro de Novos Tratamentos Itajai - Clinica de Neoplasias Litoral ( Site 0252), Itajai, Santa Catarina
Hospital de Base de Sao Jose de Rio Preto ( Site 0254), Sao Jose Rio Preto, Sao Paulo
Instituto Nacional do Cancer Jose Alencar Gomes da Silva INCA ( Site 0253), Rio de Janeiro, Not set
Instituto do Cancer do Estado de Sao Paulo - ICESP ( Site 0250), Sao Paulo, Not set
Hospital Paulistano - Amil Clinical Research ( Site 0263), Sao Paulo, Not set
Real e Benemerita Associacao Portuguesa de Beneficencia ( Site 0260), Sao Paulo, Not set
Nova Scotia Health Authority ( Site 0103), Halifax, Nova Scotia
Hamilton Health Sciences-Juravinski Cancer Centre ( Site 0107), Hamilton, Ontario
Kingston Health Sciences Centre ( Site 0102), Kingston, Ontario
Stronach Regional Cancer Centre ( Site 0100), Newmarket, Ontario
CISSS de la Monteregie-Centre ( Site 0101), Greenfield Park, Quebec
Hopital Cite de la Sante de Laval ( Site 0105), Laval, Quebec
CIUSSS Ouest de l Ile - St-Mary s Hospital ( Site 0110), Montreal, Quebec
CIUSSS de la Mauricie et du Centre du Quebec ( Site 0106), Trois-Rivieres, Quebec
Centre Hospitalier De Chauny ( Site 1411), Chauny, Aisne
CHU Caen ( Site 1406), Caen, Calvados
CHU Angers ( Site 1405), Angers, Maine-et-Loire
Institut De Cancerologie De Lorraine ( Site 1409), Vandoeuvre les Nancy, Meurthe-et-Moselle
Hopital Robert Schuman ( Site 1402), Vantoux, Moselle
Centre Jean Perrin ( Site 1407), Clermont Ferrand, Puy-de-Dome
Centre Hospitalier de Pau ( Site 1412), Pau, Pyrenees-Atlantiques
CHU de Rouen ( Site 1403), Rouen, Seine-Maritime
Hopital d'Instruction des Armees Begin ( Site 1413), Saint-Mande, Val-de-Marne
Studienzentrum Aschaffenburg ( Site 1575), Aschaffenburg, Bayern
Klinikum Bogenhausen Staedt. Klinikum Muenchen GmbH ( Site 1573), Muenchen, Bayern
Klinikum der LMU ( Site 1550), Munich, Bayern
Universitaetsklinikum Regensburg ( Site 1562), Regensburg, Bayern
Klinikum Wuerzburg Mitte gGmbH ( Site 1559), Wuerzburg, Bayern
Universitaetsklinikum Frankfurt ( Site 1563), Frankfurt, Hessen
Pneumologische Lehrklinik Universitaet Goettingen ( Site 1551), Immenhausen, Hessen
Universitaetsmedizin Goettingen ( Site 1557), Goettingen, Niedersachsen
Universitaetsklinikum Bonn ( Site 1574), Bonn, Nordrhein-Westfalen
Kliniken Essen Mitte ( Site 1567), Essen, Nordrhein-Westfalen
InVo-Institut fuer Versorgungsforschung in der Onkologie ( Site 1564), Koblenz, Rheinland-Pfalz
Helios Klinikum Erfurt GmbH ( Site 1552), Erfurt, Thuringen
Katholisches Marienkrankenhaus gGmbH ( Site 1572), Hamburg, Not set
National Hospital Organization Nagoya Medical Center ( Site 0806), Nagoya, Aichi
Aichi Cancer Center Hospital ( Site 0803), Nagoya, Aichi
National Cancer Center Hospital East ( Site 0801), Kashiwa, Chiba
Kurume University Hospital ( Site 0814), Kurume, Fukuoka
Kanazawa University Hospital ( Site 0811), Kanazawa, Ishikawa
Kanagawa Cancer Center ( Site 0807), Yokohama, Kanagawa
Sendai Kousei Hospital ( Site 0812), Sendai, Miyagi
Kansai Medical University Hospital ( Site 0804), Hirakata, Osaka
National Hospital Organization Kinki-chuo Chest Medical Center ( Site 0813), Sakai, Osaka
Shizuoka Cancer Center Hospital and Research Institute ( Site 0802), Sunto-gun, Shizuoka
National Hospital Organization Kyushu Medical Center ( Site 0805), Fukuoka, Not set
Niigata Cancer Center Hospital ( Site 0808), Niigata, Not set
Okayama University Hospital ( Site 0810), Okayama, Not set
Osaka International Cancer Institute ( Site 0809), Osaka, Not set
The Cancer Institute Hospital of JFCR ( Site 0800), Tokyo, Not set
Chungbuk National University Hospital ( Site 1002), Cheongju si, Chungbuk
National Cancer Center ( Site 1006), Goyang-si, Kyonggi-do
The Catholic University of Korea St. Vincent s Hospital ( Site 1003), Gyeonggi-do, Kyonggi-do
Ajou University Hospital ( Site 1004), Suwon, Kyonggi-do
Gyeongsang National University Hospital ( Site 1005), Jinju, Kyongsangnam-do
Asan Medical Center ( Site 1007), Songpa-gu, Seoul
Seoul National University Hospital ( Site 1000), Seoul, Not set
Severance Hospital Yonsei University Health System ( Site 1001), Seoul, Not set
Korea University Guro Hospital ( Site 1008), Seoul, Not set
Investigacion Onco Farmaceutica S de RL de CV ( Site 0300), La Paz, Baja California Sur
Hospital Civil de Guadalajara Fray Antonio Alcalde ( Site 0334), Guadalajara, Jalisco
Axis Heilsa S. de R.L. de C.V. ( Site 0301), Monterrey, Nuevo Leon
CLIMERS Clinical Medical Research ( Site 0306), Orizaba, Veracruz
Arke Estudios Clinicos ( Site 0333), Cdmx, Not set
FAICIC Clinical Research ( Site 0303), Veracruz, Not set
MidCentral DHB Palmerston North Hospital ( Site 1102), Palmerston North, Manawatu-Wanganui
Capital & Coast District Health Board - Wellington Hospital ( Site 1101), Wellington, Not set
Samodzielny Publiczny Zespol Gruzlicy i Chorob Pluc ( Site 2417), Olsztyn, Dolnoslaskie
Wielospecjalistyczny Szpital SPZOZ w Zgorzelcu ( Site 2404), Zgorzelec, Dolnoslaskie
Krakowski Szpital Specjalistyczny im Jana Pawla II ( Site 2420), Krakow, Malopolskie
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie (, Warszawa, Mazowieckie
Szpital Rejonowy im. dr Jozefa Rostka ( Site 2402), Raciborz, Slaskie
Przychodnia Lekarska Komed ( Site 2416), Konin, Wielkopolskie
MED-POLONIA Sp. z o.o. ( Site 2419), Poznan, Wielkopolskie
Cardiomed SRL Cluj-Napoca ( Site 2504), Cluj Napoca, Cluj
S.C. Radiotherapy Center Cluj S.R.L ( Site 2507), Cluj-Napoca, Cluj
S.C. Centrul de Oncologie Sf. Nectarie SRL ( Site 2508), Craiova, Dolj
Policlinica Oncomed SRL ( Site 2505), Timisoara, Timis
S.C.Focus Lab Plus S.R.L ( Site 2502), Bucuresti, Not set
Spitalul Clinic Judetean de Urgenta Sf Apostol Andrei ( Site 2501), Constanta, Not set
Moscow Regional Oncological Dispensary ( Site 2028), Balashikha, Moskovskaya Oblast
Russian Oncological Research Center n.a. N.N.Blokhin of MoH ( Site 2000), Moscow, Moskva
First Moscow State Medical University n.a. I.M.Sechenov ( Site 2024), Moscow, Moskva
Moscow Research Oncology Institute named after P.A. Hertsen ( Site 2009), Moscow, Moskva
FSAI Treatment and Rehabilitation Centre of the MoH and SD of RF ( Site 2006), Moscow, Moskva
Nizhniy Novgorod Region Oncology Dispensary ( Site 2026), Nizhniy Novgorod, Nizhegorodskaya Oblast
Budgetary Healthcare Institution of Omsk Region Clinical Oncology Dispensary-Chemotherapy #1 ( Site, Omsk, Omskaya Oblast
SBHI Samara Regional Clinical Oncology Dispensary ( Site 2016), Samara, Samarskaya Oblast
SBHI Leningrad Regional Clinical Hospital ( Site 2002), Saint Petersburg, Sankt-Peterburg
SPb Central Clinical Railway Hospital ( Site 2003), Saint Petersburg, Sankt-Peterburg
National Medical Research Center of Oncology N.A. N.N. Petrov ( Site 2004), Saint Petersburg, Sankt-Peterburg
SPb SBHI City Clinical Oncological Dispensary ( Site 2001), Saint Petersburg, Sankt-Peterburg
Republican Clinical Oncology Dispensary of Tatarstan MoH ( Site 2021), Kazan, Tatarstan, Respublika
Hospital Duran i Reynals ( Site 1710), Hospitalet de Llobregat, Barcelona
Complejo Hospitalario de Jaen ( Site 1713), Jaen, La Coruna
Hospital Sant Creu i Sant Pau ( Site 1711), Barcelona, Not set
Hospital Universitario 12 de Octubre ( Site 1716), Madrid, Not set
Complejo Hospitalario de Malaga ( Site 1714), Malaga, Not set
Hospital Universitario Virgen Macarena ( Site 1712), Sevilla, Not set
Chang Gung Medical Foundation. Kaohsiung Branch ( Site 0907), Kaohsiung, Not set
China Medical University Hospital ( Site 0904), Taichung, Not set
National Cheng Kung University Hospital ( Site 0905), Tainan, Not set
National Taiwan University Hospital ( Site 0900), Taipei, Not set
Mackay Memorial Hospital ( Site 0902), Taipei, Not set
Chang Gung Medical Foundation.Linkou Branch ( Site 0903), Taoyuan, Not set
Namik Kemal Universitesi Tip Fakultesi ( Site 2100), Tekirdag, Tekirdas
Baskent Unv. Adana Uyg. ve Arast. Hastanesi ( Site 2101), Adana, Not set
Gazi Universitesi Tip Fakultesi ( Site 2104), Ankara, Not set
Ankara Sehir Hastanesi ( Site 2105), Ankara, Not set
Bezmialem Vakif Univ. Tıp Fakultesi Hastanesi Tibbi Onkoloji Bolumu ( Site 2107), Istanbul, Not set
Göztepe Prof. Dr. Süleyman Yalçın Şehir Hastanesi-oncology ( Site 2103), Istanbul, Not set
Ege Universitesi Tip Fakultesi ( Site 2109), Izmir, Not set
Erciyes Universitesi Tip Fakultesi ( Site 2108), Kayseri, Not set
Ondokuz Mays Üniversitesi Tp Fakültesi Hastanesi-Oncology ( Site 2106), Samsun, Not set
Cherkasy Regional Oncology Dispensary ( Site 2225), Cherkasy, Cherkaska Oblast
City Clinical Hosp.4 of DCC ( Site 2215), Dnipro, Dnipropetrovska Oblast
MI Precarpathian Clinical Oncology Center ( Site 2218), Ivano-Frankivsk, Ivano-Frankivska Oblast
Grigoriev Institute for medical Radiology NAMS of Ukraine ( Site 2226), Kharkiv, Kharkivska Oblast
Regional Centre of Oncology-Thoracic organs ( Site 2219), Kharkiv, Kharkivska Oblast
PP PPC Acinus Medical and Diagnostic Centre ( Site 2223), Kropyvnytskyi, Kirovohradska Oblast
Medical Center Asklepion LLC ( Site 2243), Khodosivka, Kyivska Oblast
Kyiv City Clinical Oncology Centre ( Site 2224), Kyiv, Kyivska Oblast
Medical and Diagnostic Centre LLC Dobryi Prognoz ( Site 2227), Kyiv, Kyivska Oblast
MI Odessa Regional Oncological Centre ( Site 2222), Odesa, Odeska Oblast
Central City Clinical Hospital ( Site 2221), Uzhgorod, Zakarpatska Oblast
Medical Center Verum ( Site 2228), Kyiv, Not set
Southend University Hospital NHS Foundation Trust ( Site 1913), Westcliff-on-Sea, Essex
Barts Health NHS Trust - St Bartholomew s Hospital ( Site 1923), London, London, City Of
Chelsea and Westminster Hospital ( Site 1901), London, London, City Of
Newcastle Freeman Hospital ( Site 1902), Newcastle-upon-Tyne, Newcastle Upon Tyne
West Suffolk Hospitals NHS Trust ( Site 1919), Bury Saint Edmunds, Suffolk
Singleton Hospital ( Site 1909), Swansea, Wales
Colchester General Hospital ( Site 1911), Colchester, Worcestershire
Birmingham Heartlands Hospital ( Site 1910), Birmingham, Not set
Western General Hospital, Edinburgh ( Site 1924), Edinburg, Not set
Conditions: Carcinoma, Squamous Cell, Non-small-cell Lung
Combination Chemotherapy, Autologous Stem Cell Transplant, and/or Radiation Therapy in Treating Young Patients With Extraocular Retinoblastoma
Completed
This phase III trial is studying the side effects and how well giving combination chemotherapy together with autologous stem cell transplant and/or radiation therapy works in treating young patients with extraocular retinoblastoma. Giving chemotherapy before an autologous stem cell transplant stops the growth of tumor cells by stopping them from dividing or killing them. After treatment, stem cells are collected from the patient's blood and/or bone marrow and stored. More chemotherapy is given t... Read More
This phase III trial is studying the side effects and how well giving combination chemotherapy together with autologous stem cell transplant and/or radiation therapy works in treating young patients with extraocular retinoblastoma. Giving chemotherapy before an autologous stem cell transplant stops the growth of tumor cells by stopping them from dividing or killing them. After treatment, stem cells are collected from the patient's blood and/or bone marrow and stored. More chemotherapy is given to prepare the bone marrow for the stem cell transplant. The stem cells are then returned to the patient to replace the blood-forming cells that were destroyed by the chemotherapy. Radiation therapy uses high energy x-rays to kill tumor cells. Giving radiation therapy after combination chemotherapy and/or autologous stem cell transplant may kill any remaining tumor cells. Read Less
Gender:
ALL
Ages:
10 years and below
Trial Updated:
01/03/2025
Locations: Children's Hospital of Alabama, Birmingham, Alabama +72 locations
Children's Hospital of Alabama, Birmingham, Alabama
University of Alabama at Birmingham Cancer Center, Birmingham, Alabama
Phoenix Childrens Hospital, Phoenix, Arizona
Arkansas Children's Hospital, Little Rock, Arkansas
University of Arkansas for Medical Sciences, Little Rock, Arkansas
Kaiser Permanente Downey Medical Center, Downey, California
Children's Hospital Los Angeles, Los Angeles, California
Lucile Packard Children's Hospital Stanford University, Palo Alto, California
UCSF Medical Center-Parnassus, San Francisco, California
UCSF Medical Center-Mission Bay, San Francisco, California
Children's Hospital Colorado, Aurora, Colorado
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center, Denver, Colorado
Connecticut Children's Medical Center, Hartford, Connecticut
Alfred I duPont Hospital for Children, Wilmington, Delaware
Children's National Medical Center, Washington, District of Columbia
Nemours Children's Clinic-Jacksonville, Jacksonville, Florida
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida
Nemours Children's Clinic - Orlando, Orlando, Florida
Nemours Children's Hospital, Orlando, Florida
Nemours Children's Clinic - Pensacola, Pensacola, Florida
Johns Hopkins All Children's Hospital, Saint Petersburg, Florida
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa, Florida
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia
Lurie Children's Hospital-Chicago, Chicago, Illinois
University of Illinois, Chicago, Illinois
Riley Hospital for Children, Indianapolis, Indiana
University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa
University of Kentucky/Markey Cancer Center, Lexington, Kentucky
Walter Reed National Military Medical Center, Bethesda, Maryland
Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Dana-Farber Cancer Institute, Boston, Massachusetts
University of Mississippi Medical Center, Jackson, Mississippi
Children's Mercy Hospitals and Clinics, Kansas City, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Sunrise Hospital and Medical Center, Las Vegas, Nevada
Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas, Nevada
Summerlin Hospital Medical Center, Las Vegas, Nevada
Nevada Cancer Research Foundation NCORP, Las Vegas, Nevada
Morristown Medical Center, Morristown, New Jersey
Memorial Sloan Kettering Cancer Center, New York, New York
New York Medical College, Valhalla, New York
Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina
Novant Health Presbyterian Medical Center, Charlotte, North Carolina
Duke University Medical Center, Durham, North Carolina
Children's Hospital Medical Center of Akron, Akron, Ohio
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Rainbow Babies and Childrens Hospital, Cleveland, Ohio
Cleveland Clinic Foundation, Cleveland, Ohio
Dayton Children's Hospital, Dayton, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Penn State Children's Hospital, Hershey, Pennsylvania
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Children's Oncology Group, Philadelphia, Pennsylvania
Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
Saint Jude Children's Research Hospital, Memphis, Tennessee
Medical City Dallas Hospital, Dallas, Texas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas
Cook Children's Medical Center, Fort Worth, Texas
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas
M D Anderson Cancer Center, Houston, Texas
Children's Hospital of San Antonio, San Antonio, Texas
Methodist Children's Hospital of South Texas, San Antonio, Texas
University of Texas Health Science Center at San Antonio, San Antonio, Texas
Virginia Commonwealth University/Massey Cancer Center, Richmond, Virginia
Saint Vincent Hospital Cancer Center Green Bay, Green Bay, Wisconsin
Children's Hospital of Wisconsin, Milwaukee, Wisconsin
Hospital de Pediatria Juan P Garrahan, Buenos Aires, Not set
The Children's Hospital at Westmead, Westmead, New South Wales
Princess Margaret Hospital for Children, Perth, Western Australia
Instituto De Oncologia Pediatrica, Sao Paulo, Not set
IWK Health Centre, Halifax, Nova Scotia
Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec
Children's Cancer Hospital, El Saida Zenab, Cairo
Conditions: Extraocular Retinoblastoma
Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice and Pembrolizumab in Patients With Previously Untreated, Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer
Active Not Recruiting
The primary objective of this study is to compare the progression-free survival (PFS) between sacituzumab govitecan-hziy (SG) and pembrolizumab versus treatment of physician's choice (TPC) and pembrolizumab in participants with previously untreated, locally advanced inoperable or metastatic triple-negative breast cancer, whose tumors express programmed cell death ligand 1 (PD-L1).
The primary objective of this study is to compare the progression-free survival (PFS) between sacituzumab govitecan-hziy (SG) and pembrolizumab versus treatment of physician's choice (TPC) and pembrolizumab in participants with previously untreated, locally advanced inoperable or metastatic triple-negative breast cancer, whose tumors express programmed cell death ligand 1 (PD-L1). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/19/2024
Locations: Alaska Oncology and Hematology, Anchorage, Alaska +503 locations
Alaska Oncology and Hematology, Anchorage, Alaska
Arizona Oncology Associates, PC-Hope,1845 W Orange Grove Rd, Tucson, Arizona
Arizona Oncology Associates, PC-Hope,2070 W. Rudasill Rd., Tucson, Arizona
Arizona Oncology Associates, PC-Hope, Tucson, Arizona
Arizona Oncology Associates, PC-Hope,1620 West St. Mary's Road, Tucson, Arizona
Genesis Cancer and Blood Institute, Hot Springs, Arkansas
Genesis Cancer and Blood Institute,1456 Higdon Ferry Road Suite B., Hot Springs, Arkansas
Saint Bernards Medical Center, Jonesboro, Arkansas
Saint Bernards Medical Center,4000 Linwood Drive, Paragould, Arkansas
University of California Los Angeles - Jonsson Comprehensive Cancer Center,201 S. Buena Vista Street, Suite 200, Burbank, California
University of California Irvine Health Chao Family,1640 Newport Blvd, Costa Mesa, California
City of Hope, Duarte, California
University of California San Diego Moores Cancer, La Jolla, California
University of California Los Angeles - Jonsson Comprehensive Cancer Center,24302 Paseo de Valencia, Suite 200, Laguna Hills, California
Cancer and Blood Specialty Clinic, Los Alamitos, California
City of Hope,1601 Avocado Ave, Newport, California
University of California Irvine Health Chao Family, Orange, California
City of Hope,209 Fair Oaks Ave, Pasadena, California
University of California Los Angeles - Jonsson Comprehensive Cancer Center,892 Aerovista Place, Suite 240, San Luis Obispo, California
Sansum Clinic, Santa Barbara, California
University of California Los Angeles - Jonsson Comprehensive Cancer Center,2020 Santa Monica Blvd, Suite 600, Santa Monica, California
University of California Los Angeles - Jonsson Comprehensive Cancer Center,2336 Santa Monica, Suites 302 and 304, Santa Monica, California
University of California Los Angeles - Jonsson Comprehensive Cancer Center, Santa Monica, California
St. Jude Hospital Yorba dba St. Joseph Heritage Healthcare, Santa Rosa, California
Sansum Clinic,2040 Viborg Road, Solvang, California
City of Hope,5215 Torrance Blvd, Torrance, California
Torrance Memorial Physician Network - Cancer Care, Torrance, California
City of Hope,1100 San Bernardino Rd, Upland, California
University of California Los Angeles - Jonsson Comprehensive Cancer Center,1250 La Venta Dr, Suite 100, Westlake Village, California
Rocky Mountain Cancer Centers,1700 South Potomac Street, Aurora, Colorado
Rocky Mountain Cancer Centers, Boulder, Colorado
Rocky Mountain Cancer Centers,2312 N. Nevada Avenue, Colorado Springs, Colorado
Rocky Mountain Cancer Centers,6031 E. Woodman Rd., Colorado Springs, Colorado
Rocky Mountain Cancer Centers,4700 E. Hale Parkway, Denver, Colorado
Rocky Mountain Cancer Centers,11750 West 2nd Place, Lakewood, Colorado
Rocky Mountain Cancer Centers,22 West Dry Creek Circle, Littleton, Colorado
Rocky Mountain Cancer Centers,10107 Ridge Gate Parkway, Lone Tree, Colorado
Rocky Mountain Cancer Centers,2030 Mountain View Ave Ste 210, Longmont, Colorado
Rocky Mountain Cancer Centers,3676 Parker Blvd, Pueblo, Colorado
Rocky Mountain Cancer Centers,525 W. 15th Street, Pueblo, Colorado
Rocky Mountain Cancer Centers,8820 Huron Street, Thornton, Colorado
Eastern Connecticut Hematology and Oncology Associates, Norwich, Connecticut
Advent Health Medical Group, Altamonte Springs, Florida
SCRI - Florida Cancer Specialists - North Region R,750 Orienta Ave, Altamonte Springs, Florida
University of Miami - Sylvester Comprehensive Cancer Center,2801 NE 213th St, Aventura, Florida
Florida Cancer Specialists,9776 Bonita Beach Road Southeast Suite 201 A, Bonita Springs, Florida
Florida Cancer Specialists,3630 Manatee Avenue West, Bradenton, Florida
Florida Cancer Specialists,5985 Silver Falls Run, Bradenton, Florida
SCRI - Florida Cancer Specialists - North Region R,403 S. Kings Ave., Brandon, Florida
Florida Cancer Specialists,1030 Commerce Creek Blvd, Cape Coral, Florida
SCRI - Florida Cancer Specialists - North Region R,3280 McMullen Booth Road, Clearwater, Florida
University of Miami - Sylvester Comprehensive Cancer Center,5555 Ponce De Leon Blvd, Coral Gables, Florida
SCRI - Florida Cancer Specialists - West Palm Beach,224 Memorial Medical Parkway, Suite 300, Daytona Beach, Florida
University of Miami - Sylvester Comprehensive Cancer Center,1192 East Newport Center Drive, Deerfield Beach, Florida
Florida Cancer Specialists, Fort Myers, Florida
Florida Cancer Specialists,8981 Colonial Center Drive, Fort Myers, Florida
Florida Cancer Specialists,8260 Gladiolus Dr, Fort Myers, Florida
SCRI - Florida Cancer Specialists - North Region R,6420 W. Newberry Road, Gainesville, Florida
University of Miami - Sylvester Comprehensive Cancer Center,3850 Hollywood Blvd, Hollywood, Florida
SCRI - Florida Cancer Specialists - North Region R,100 Highland Avenue, Largo, Florida
SCRI - Florida Cancer Specialists - North Region R,521 North Lecanto Highway, Lecanto, Florida
University of Miami - Sylvester Comprehensive Cancer Center,1400 NW 12th Ave, Miami, Florida
University of Miami - Sylvester Comprehensive Cancer Center, Miami, Florida
University of Miami - Sylvester Comprehensive Cancer Center,8932 S.W. 97 Ave, Miami, Florida
Florida Cancer Specialists,1100 Goodlette Road, Naples, Florida
SCRI - Florida Cancer Specialists - North Region R,4945 SW 49th Place, Ocala, Florida
SCRI - Florida Cancer Specialists - North Region R,2824 Enterprise Rd, Orange City, Florida
Advent Health Medical Group,2501 North Orange Ave, Orlando, Florida
SCRI - Florida Cancer Specialists - North Region R,70 W. Gore Street, Orlando, Florida
University of Miami - Sylvester Comprehensive Cancer Center,8100 SW 10 Street, Plantation, Florida
Florida Cancer Specialists,22395 Edgewater Drive, Port Charlotte, Florida
SCRI - Florida Cancer Specialists - North Region R,1201 Fifth Avenue North, Saint Petersburg, Florida
SCRI - Florida Cancer Specialists - North Region R, Saint Petersburg, Florida
Florida Cancer Specialists,600 North Cattlemen Road, Sarasota, Florida
Florida Cancer Specialists,1970 Golf Street, Sarasota, Florida
SCRI - Florida Cancer Specialists - North Region R,7154 Medical Center Drive, Spring Hill, Florida
SCRI - Florida Cancer Specialists - West Palm Beach,301 SE Ocean Blvd, Suite 102, Stuart, Florida
SCRI - Florida Cancer Specialists - North Region R,3402 West Dr. Martin Luther King Jr. Boulevard, Tampa, Florida
SCRI - Florida Cancer Specialists - North Region R,4100 Waterman Way, Tavares, Florida
SCRI - Florida Cancer Specialists - North Region R,1400 US Highway 441 N, The Villages, Florida
SCRI - Florida Cancer Specialists - North Region R,9320 State Road 54, Trinity, Florida
Florida Cancer Specialists,836 Sunset Lake Blvd, Venice, Florida
SCRI - Florida Cancer Specialists - West Palm Beach,3730 7th Terrace, Suite 101, Vero Beach, Florida
SCRI - Florida Cancer Specialists - West Palm Beach,1037 S. State Road 7, Bldg B, Suite 303, Wellington, Florida
SCRI - Florida Cancer Specialists - West Palm Beach, West Palm Beach, Florida
SCRI - Florida Cancer Specialists - North Region R,460 N Orlando Ave, Winter Park, Florida
Northside Hospital,125 King Avenue, Athens, Georgia
Piedmont Cancer Institute - Atlanta,1267 Hwy 54W, Atlanta, Georgia
Winship Cancer Institute of Emory University,550 Peachtree St NE, Atlanta, Georgia
Piedmont Cancer Institute - Atlanta, Atlanta, Georgia
Winship Cancer Institute of Emory University, Atlanta, Georgia
Northside Hospital,5670 Peachtree Dunwoody Rd., Atlanta, Georgia
Northside Hospital, Atlanta, Georgia
Winship Cancer Institute of Emory University,5665 Peachtree Dunwoody Road, Atlanta, Georgia
Northside Hospital,308 Deep South Farm Rd, Suite 200, Blairsville, Georgia
Northside Hospital,228 Riverstone Dr., Canton, Georgia
Northside Hospital,1505 Northside Blvd, Suite 4600, Cumming, Georgia
Northside Hospital,3855 Pleasant Hill Rd., Suite 480, Duluth, Georgia
Northside Hospital,308 Coliseum Dr., Macon, Georgia
Piedmont Cancer Institute - Atlanta,775 Poplar Road, Newnan, Georgia
Piedmont Cancer Institute - Atlanta,1240 Eagles Landing Pkwy, Stockbridge, Georgia
Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois
University of Illinois Hospital and Health Sciences System (Outpatient Cancer Center), Chicago, Illinois
Orchard Healthcare Research Inc,2845 North Sheridan Road, 1st Floor, Chicago, Illinois
Robert H. Lurie Comprehensive Cancer Center of Northwestern University,1 Kish Hospital Drive, DeKalb, Illinois
Robert H. Lurie Comprehensive Cancer Center of Northwestern University,10 Health Services Drive, DeKalb, Illinois
Orchard Healthcare Research Inc,800 Austin Street, Suite 360, East Tower, Evanston, Illinois
Robert H. Lurie Comprehensive Cancer Center of Northwestern University,300 Randall Road, Geneva, Illinois
Robert H. Lurie Comprehensive Cancer Center of Northwestern University,304 Randall Road, Geneva, Illinois
Robert H. Lurie Comprehensive Cancer Center of Northwestern University,1000 N. Westmoreland Road, Lake Forest, Illinois
Orchard Healthcare Research Inc, Skokie, Illinois
Robert H. Lurie Comprehensive Cancer Center of Northwestern University,4405 Weaver Parkway, Warrenville, Illinois
Robert H. Lurie Comprehensive Cancer Center of Northwestern University,4455 Weaver Parkway, Warrenville, Illinois
Robert H. Lurie Comprehensive Cancer Center of Northwestern University,25 N Winfield Road, Winfield, Illinois
Regulatory Management Only: TRIO-US Central Administration, Fort Wayne, Indiana
The University of Kansas Cancer Center,2000 Olathe Blvd, Kansas City, Kansas
The University of Kansas Cancer Center,12200 W. 110th Street, Overland Park, Kansas
The University of Kansas Cancer Center,10710 Nall Avenue, Overland Park, Kansas
The University of Kansas Cancer Center,10730 Nall Avenue, Overland Park, Kansas
The University of Kansas Cancer Center, Westwood, Kansas
Norton Cancer Institute - Saint Matthews,234 E. Gray Strret, Louisville, Kentucky
Norton Cancer Institute - Saint Matthews,676 S. Floyd Street, Louisville, Kentucky
Norton Cancer Institute - Saint Matthews, Louisville, Kentucky
Norton Cancer Institute - Saint Matthews,4955 Norton Healthcare Blvd, Louisville, Kentucky
Hematology Oncology Clinic - Baton Rouge, Baton Rouge, Louisiana
Hematology Oncology Clinic - Baton Rouge,1673 E Mount Please Drive, Zachary, Louisiana
Cancer Institute Ascension Saint Agnes, Baltimore, Maryland
Beth Israel Deaconess Medical Center, Boston, Massachusetts
Dana-Farber Cancer Institute, Boston, Massachusetts
Massachusetts General Hospital, Boston, Massachusetts
Massachusetts General Hospital,102 Endicott Street, Danvers, Massachusetts
Massachusetts General Hospital,2014 Washington St, Newton, Massachusetts
University of Michigan, Ann Arbor, Michigan
Ascension St. John Hospital, Grosse Pointe Woods, Michigan
Ascension Providence Hospital Southfield Cancer Center, Southfield, Michigan
Mayo Clinic, Rochester, Minnesota
The West Clinic, PLLC dba West Cancer Center,7668 Airways Blvd, Southaven, Mississippi
The University of Kansas Cancer Center,2750 Clay Edwards Drive, Kansas City, Missouri
The University of Kansas Cancer Center,8700 North Green Hills Road, Kansas City, Missouri
The University of Kansas Cancer Center,4881 N.E. Goodview Circle, Lee's Summit, Missouri
Nebraska Cancer Specialists,2730 W. Faidley Ave, Grand Island, Nebraska
Nebraska Cancer Specialists,8303 Dodge Street, Omaha, Nebraska
Nebraska Cancer Specialists, Omaha, Nebraska
Nebraska Cancer Specialists,611 Fenwick Dr, Papillion, Nebraska
Comprehensive Cancer Centers of Nevada - Central V,10001 S. Eastern Avenue, Suite 108, Henderson, Nevada
Comprehensive Cancer Centers of Nevada - Central V,2460 W. Horizon Ridge Parkway, Henderson, Nevada
Comprehensive Cancer Centers of Nevada - Central V,1501 Wigwam Parkway, Suite 1300, Henderson, Nevada
Comprehensive Cancer Centers of Nevada - Central V,653 North Town Center Drive, Suite 402, Las Vegas, Nevada
Comprehensive Cancer Centers of Nevada - Central V,9280 W. Sunset Road Suite 100, Las Vegas, Nevada
Comprehensive Cancer Centers of Nevada - Central V,7445 Peak Drive, Las Vegas, Nevada
Comprehensive Cancer Centers of Nevada - Central V, Las Vegas, Nevada
Summit Medical Group,1 Diamond Hill Road, Berkeley Heights, New Jersey
Regional Cancer Care Associates - East Brunswick, East Brunswick, New Jersey
Summit Medical Group, Florham Park, New Jersey
John Theurer Cancer Center, Hackensack, New Jersey
Rutgers Cancer Institute of New Jersey,2575 Klockner Road, Hamilton, New Jersey
Rutgers Cancer Institute of New Jersey,414 Grand Street, Jersey City, New Jersey
Rutgers Cancer Institute of New Jersey,600 River Avenue, Lakewood, New Jersey
Rutgers Cancer Institute of New Jersey,94 Old Short Hills Road, Livingston, New Jersey
Rutgers Cancer Institute of New Jersey,300 Second Ave, Long Branch, New Jersey
Regional Cancer Care Associates - East Brunswick,9 Centre Drive, Monroe, New Jersey
Regional Cancer Care Associates - East Brunswick,34-36 Progress Street, New Brunswick, New Jersey
Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey
Rutgers Cancer Institute of New Jersey,150 Bergen St., Newark, New Jersey
Rutgers Cancer Institute of New Jersey,201 Lyons Avenue, Newark, New Jersey
Regional Cancer Care Associates - East Brunswick,75 Veronica Avenue, Somerset, New Jersey
Rutgers Cancer Institute of New Jersey,110 Rehill Ave, Somerville, New Jersey
Rutgers Cancer Institute of New Jersey,99 Highway 37 West, Toms River, New Jersey
Rutgers Cancer Institute of New Jersey,100 State Route 36, West Long Branch, New Jersey
New York Cancer & Blood Specialists - Port Jeffers,72 East Main St., Babylon, New York
New York Cancer & Blood Specialists - Port Jeffers,12 East 86th St, Suite 4, Bronx, New York
Montefiore Medical Center - Montefiore Medical Park, Bronx, New York
New York Cancer & Blood Specialists - Port Jeffers,2330 Eastchester Road, Suite 360, Bronx, New York
Perlmutter Cancer Center - Manhattan - 34th Street,259 First Street, Mineola, New York
New York Cancer & Blood Specialists - Port Jeffers,1 Delaware Dr., New Hyde Park, New York
Perlmutter Cancer Center - Manhattan - 34th Street, New York, New York
NYP/Columbia Univeresity Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York
New York Cancer & Blood Specialists - Port Jeffers,365 East Main St., Patchogue, New York
New York Cancer & Blood Specialists - Port Jeffers,49 Rte. 347, Newconset Hwy, Port Jefferson Station, New York
New York Cancer & Blood Specialists - Port Jeffers, Port Jefferson Station, New York
New York Cancer & Blood Specialists - Port Jeffers,1500 Rte, 112, Building 4, Port Jefferson, New York
New York Cancer & Blood Specialists - Port Jeffers,750 Old County Rd. Suite 4, Riverhead, New York
The Ohio State University Wexner Medical Center Clinical Laboratories, Columbus, Ohio
Zangmeister Cancer Center, Columbus, Ohio
Northwest Cancer Specialists, PC,5050 NE Hoyt St., Portland, Oregon
Northwest Cancer Specialists, PC,265 N. Broadway, Portland, Oregon
Northwest Cancer Specialists, PC, Tigard, Oregon
Magee-Womens Hospital of UPMC,200 Oxford Drive, Bethel Park, Pennsylvania
Magee-Womens Hospital of UPMC,3 St. Francis Way, Cranberry Township, Pennsylvania
Magee-Womens Hospital of UPMC,2500 West 12th Street, Erie, Pennsylvania
Magee-Womens Hospital of UPMC,201 State Street, 6 Main, Erie, Pennsylvania
Magee-Womens Hospital of UPMC,200 Village Drive, Greensburg, Pennsylvania
Magee-Womens Hospital of UPMC,400 Oxford Drive, Monroeville, Pennsylvania
University of Pennsylvania Abramson Cancer Center, Philadelphia, Pennsylvania
Magee-Womens Hospital of UPMC,300 Halket Street, Pittsburgh, Pennsylvania
Magee-Womens Hospital of UPMC, Pittsburgh, Pennsylvania
Magee-Womens Hospital of UPMC,5115 Centre Avenue, Pittsburgh, Pennsylvania
Magee-Womens Hospital of UPMC,9100 Babcock Boulevard, Pittsburgh, Pennsylvania
Magee-Womens Hospital of UPMC,100 Fairfield Dr, Seneca, Pennsylvania
Magee-Womens Hospital of UPMC,470 Johnson Road, Washington, Pennsylvania
Magee-Womens Hospital of UPMC,1703 Innovation Drive, York, Pennsylvania
Rhode Island Hospital, Providence, Rhode Island
Rhode Island Hospital,164 Summit Ave, Fain 275A, Providence, Rhode Island
Tennessee Oncology, PLLC,103 Natchez Park Drive, Dickson, Tennessee
Tennessee Oncology, PLLC,4488 Carothers Parkway, Franklin, Tennessee
Tennessee Oncology, PLLC,225 Big Station Camp Blvd, Gallatin, Tennessee
The West Clinic, PLLC dba West Cancer Center, Germantown, Tennessee
Tennessee Oncology, PLLC,353 New Shackle Island Road, Hendersonville, Tennessee
Tennessee Oncology, PLLC,5653 First Blvd., Hermitage, Tennessee
Tennessee Oncology, PLLC,103 Physicians Way, Lebanon, Tennessee
Tennessee Oncology, PLLC,1840 Medical Center Parkway, Murfreesboro, Tennessee
Tennessee Oncology, PLLC,2004 Hayes Street, Nashville, Tennessee
Tennessee Oncology, PLLC,SCRI Oncology Partners, Nashville, Tennessee
Tennessee Oncology, PLLC, Nashville, Tennessee
Tennessee Oncology, PLLC,4220 Harding Rd, Nashville, Tennessee
Tennessee Oncology, PLLC,3443 Dickerson Road, Nashville, Tennessee
Tennessee Oncology, PLLC,397 Wallace Road, Nashville, Tennessee
Tennessee Oncology, PLLC,120 Frank Martin Road, Shelbyville, Tennessee
Tennessee Oncology, PLLC,300 Stonecrest Blvd, Smyrna, Tennessee
The Center for Cancer and Blood Disorders - Magnolia,515 W. Mayfield Rd., Arlington, Texas
Texas Oncology-Austin,901 West 38th Street, Austin, Texas
Texas Oncology-Austin, Austin, Texas
Texas Oncology-Austin,4101 James Casey, Suite 100, Austin, Texas
The Center for Cancer and Blood Disorders - Magnolia,11805 South Freeway, Burleson, Texas
Texas Oncology-Baylor Charles A. Sammons Cancer Center, Dallas, Texas
Texas Oncology-Denison, Denison, Texas
The Center for Cancer and Blood Disorders - Magnolia, Fort Worth, Texas
Oncology Consultants,1631 North Loop West, Houston, Texas
Oncology Consultants,925 Gessner, Houston, Texas
Oncology Consultants, Houston, Texas
University of Texas MD Anderson Cancer Center,1155 Pressler St, Houston, Texas
University of Texas MD Anderson Cancer Center, Houston, Texas
Mays Cancer Center, San Antonio, Texas
The Center for Cancer and Blood Disorders - Magnolia,920 Santa Fe Drive, Weatherford, Texas
Huntsman Cancer Institute, University of Utah,165 North University Avenue, Farmington, Utah
Huntsman Cancer Institute, University of Utah,1280 E. Stringham Avenue, Salt Lake City, Utah
Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah
Huntsman Cancer Institute, University of Utah,5126 West Daybreak Parkway, South Jordan, Utah
Virginia Oncology Associates,744 N. Battlefield Blvd, Chesapeake, Virginia
Virginia Cancer Institute,7501 Right Flank Road, Mechanicsville, Virginia
Virginia Oncology Associates,1051 Loftis Blvd Suite 100, Newport News, Virginia
Virginia Oncology Associates, Norfolk, Virginia
Virginia Cancer Institute,210 Medical Park Boulevard, Petersburg, Virginia
Virginia Cancer Institute,1401 Johnston-Willis Drive, Richmond, Virginia
Virginia Cancer Institute, Richmond, Virginia
Virginia Oncology Associates,1950 Glenn Mitchell Drive, Virginia Beach, Virginia
Northwest Cancer Specialists, PC,210 SE 136th Avenue, Vancouver, Washington
Hospital Británico de Buenos Aires, Buenos Aires, Not set
Instituto de Oncología Ángel H. Roffo, Caba, Not set
Fundacion CORI para la Investigacioy y Prevención del Cancer, Capital, Not set
Instituto de Oncologia de Rosario, Rosario, Not set
CAIPO Centro Para La Atención Integral Del Pacient, San Miguel de Tucumán, Not set
Clinica Viedma, Viedma, Not set
Border Medical Oncology, Albury, New South Wales
Saint George Hospital - Australia, Kogarah, New South Wales
Mater Hospital - North Sydney, North Sydney, New South Wales
GenesisCare - North Shore, St Leonards, New South Wales
Mater Misericordiae Limited and Mater Research Limited, South Brisbane, Queensland
Princess Alexandra Hospital, Woolloongabba, Queensland
Cancer Research SA (CRSA), Adelaide, South Australia
Icon Cancer Centre Hobart, Hobart, Tasmania
Monash Medical Centre, Clayton, Victoria
Austin Hospital, Melbourne, Victoria
Peter MacCallum Cancer Centre, Parkville, Victoria
Breast Cancer Research Center - Western Australia, Nedlands, Western Australia
Medizinische Universität Innsbruck, Innsbruck, Not set
Ordensklinikum Linz GmbH Barmherzige Schwestern, Linz, Not set
Landeskrankenhaus Salzburg, Salzburg, Not set
Universitätsklinikum Sankt Pölten, Sankt Poelten, Not set
Medizinische Universität Wien, Wien, Not set
Institut Jules Bordet, Anderlecht, Not set
Algemeen Ziekenhuis Klina, Brasschaat, Not set
Cliniques Universitaires Saint-Luc, Brussels, Not set
Universitair Ziekenhuis Brussel, Brussels, Not set
Grand Hopital de Charleroi - Notre Dame, Charleroi, Not set
Universitair Ziekenhuis Gent, Gent, Not set
UZ Leuven, Leuven, Not set
Centre Hospitalier Universitaire Université Cathol, Namur, Not set
Hospital Araújo Jorge - Associacao de Combate ao Cancer em Goias - ACCG, Goiânia, Not set
Centro de Pesquisa Clinica Em Oncologia - ONCOSITE, Ijui, Not set
Hospital de Clinicas de Porto Alegre - HCPA, Itajai, Not set
Centro de Pesquisas Clinicas da Fundacao Doutor Amaral Carvalho - Hospital Amarval Carvalho, Jau, Not set
Associacao Hosptialar Moinos de Vento - Hospital Moinhos de Vento, Porto Alegre, Not set
Hospital de Clínicas de Porto Alegre, Porto Alegre, Not set
Hospital Sao Lucas da PUCRS, Porto Alegre, Not set
Instituto Nacional de Câncer - Brazil, Rio de Janeiro, Not set
Núcleo de Oncologia da Bahia, Salvador, Not set
CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia - Centro Universitário FMABC, Santo Andre, Not set
Real e Benemerita Associacao Portuguesa de Beneficencia - Hospital Beneficencia Portuguesa (BP) - Unidade Paulista, São Paulo, Not set
Clinica de Pesquisas e Centro de Estudos em Oncolo, São Paulo, Not set
Fundação Pio XII - Hospital de Câncer de Barretos, São Paulo, Not set
Nucleo de Pesquisa Clinica da Rede Sao Camilo, São Paulo, Not set
Tom Baker Cancer Centre, Calgary, Not set
Cross Cancer Institute, Edmonton, Not set
QEII Health Sciences Centre, Halifax, Not set
Grand River Regional Cancer Centre at Grand River Hospital, Kitchener, Not set
London Health Sciences Centre, London, Not set
McGill University Health Centre, Montreal, Not set
Jewish General Hospital, Montréal, Not set
Princess Margaret Cancer Centre - University Health Network, Ontario, Not set
Ottawa Hospital - General Campus, Ottawa, Not set
Sunnybrook Research Institute, Toronto, Not set
Mount Sinai Hospital, Toronto, Not set
British Columbia Cancer - Vancouver, Vancouver, Not set
Oncovida - Santiago, Providencia, Not set
Clínica IRAM, Santiago DE CHILE, Not set
Centro de Cancer Pontificia Universidad Catolica, Santiago Region, Not set
Clínica Alemana, Santiago, Not set
James Lind Centro de Investigacion del Cancer, Temuco, Not set
Masarykuv Onkologicky Ustav, Klinika Komplexni Onkologicke Pece, Brno, Not set
Fakultní Thomayerova nemocnice, Hradec Kralove, Not set
Fakultní Nemocnice Hradec Králové, Hradec Králové, Not set
Fakultni nemocnice Olomouc, Onkologicka klinika, Olomouc, Not set
Vseobecna Fakultni Nemocnice v Praze, Onkologicka klinika, Prague, Not set
Fakultní Nemocnice Královské Vinohrady, Radioterapeuticka a onkologicka klinika, Praha, Not set
Sainte Catherine Institut du Cancer Avignon Provence, Avignon, Not set
Centre Hospitalier Régional et Universitaire de Be, Besancon, Not set
Polyclinique Bordeaux Nord Aquitaine, Bordeaux, Not set
Hôpital Morvan, Institut de cancérologie, Brest, Not set
Centre de Lutte contre le Cancer - François Bacles, Caen, Not set
Centre Jean Perrin, Clermont Ferrand, Not set
Centre Leon Berard, Lyon, Not set
Institut Paoli-Calmettes, Marseille CEDEX 9, Not set
Institut Régional du Cancer de Montpellier, Montpellier Cedex 5, Not set
Centre de Cancérologie du Grand Montpellier, Montpellier, Not set
Hôpital Privé du Confluent, Nantes, Not set
Hospices Civils de Lyon, Hôpital Lyon Sud, Pierre-Benite, Not set
Centre Armoricain de Radiothérapie, dImagerie Méd, Plerin, Not set
Centre Eugène Marquis, Rennes Cedex, Not set
Institut Claudius Regaud - IUCT-O, Toulouse, Not set
Institut Gustave Roussy, Villejuif, Not set
Helios Klinikum Berlin-Buch, Berlin, Not set
: Gynakologisches Zentrum Bonn, Schwerpunkt Gyn. Onkologie,, Bonn, Not set
Marienhospital Bottrop, Bottrop, Not set
Universitätsklinikum Erlangen, Frauen klinik, Erlangen, Not set
Kliniken Essen-Mitte - Evangelische Huyssens-Stift, Essen, Not set
Praxis für interdisziplinäre Onkologie & Hämatolog, Freiburg, Not set
: Universitätsklinikum Hamburg-Eppendorf, Hamburg, Not set
Facharztzentrum Eppendorf, Hamburg, Not set
Nationales Centrum für Tumorerkrankungen, Heidelberg, Not set
Klinik Frauenheilkunde, Uniklinik ClO, Studienzentrale, Köln, Not set
Universitätsklinikum Schleswig-Holstein Institut fur Klinische Chermie, Lübeck, Not set
Universitatsklinikum Mannheim GmBH, Frauenklinik, Mannheim, Not set
Universitätsklinikum Münster, Bereich Senologie an der klinik fur Frauenheilkunde und Gerburtschilfe, Munster, Not set
EV. Krankenhaus Bethesda - Johanniter GmbH, Station 1 Brustzentrum Niederrhein, Mönchengladbach, Not set
Rotkreuzklinikum Munchen Frauenklinik, München, Not set
Klinik und Poliklinik für Frauenheilkunde, München, Not set
Universitatsklinikum Tubingen, Tübingen, Not set
St. Josefs-Hospital Wiesbaden GmbH, Gynakologie und Geburtshilfe, Wiesbaden, Not set
Department of Medicine, Queen Mary Hospital, Hong Kong, Not set
Hong Kong Sanatorium and Hospital, Hong Kong, Not set
Tuen Mun Hospital, Hong Kong, Not set
Prince of Wales Hospital - Hong Kong, New Territories, Not set
Orszagos Onkologiai Intezet, Budapest, Not set
Uzsoki Utcai Kórház, Budapest, Not set
Debreceni Egyetem Klinikai Központ, Debrecen, Not set
Petz Aladár Egyetemi Oktató Kórház - Gy?r, Gyor, Not set
Soroka Medical Center, Beer-Sheva, Not set
Rambam Health Care Campus, Haifa, Not set
Shaare Zedek Medical Center, Jerusalem, Not set
Hadassah - Hebrew University Medical Center, Jerusalem, Not set
Meir Medical Center, Kfar Saba, Not set
Rabin Medical Center, Petah Tikva, Not set
Kaplan Medical Center, Rehovot, Not set
Sheba Medical Center Hospital - Tel Hashomer, Tel Aviv, Not set
Tel Aviv Sourasky Medical Center, Tel Aviv, Not set
IRCCS Istituto Tumori "Giovanni Paolo II", Bari, Not set
SSD Oncologia Medica Addarii-Zamagni, IRCSS Azienda Ospedaliero-Universitaria di Bologna - Policlinico di Sant'Orsola, Bologna, Not set
UO Oncologia, ASST degli Spedali Civili di Brescia, Brescia, Not set
IRCCS Ospedale Policlinico San Martino, Genova GE, Not set
S.C. Oncologia medica, ASST di Lecco, Lecco, Not set
Presidio Ospedaliero di Lucca, Lucca, Not set
Ospedale Generale Provinciale - Macerata, Macerata, Not set
Ospedale San Raffaele, Milano, Not set
Fondazione IRCCS - Istituto Nazionale dei Tumori, Milano, Not set
Istituto Europeo di Oncologia, Milan, Not set
Centro Ricerca Fase I, Fondazione IRCSS San Gerado dei Tintori, Monza, Not set
AOU "Luigi Vanvitelli", Napoli, Not set
Oncologia Medica Senologica Sperimentale - Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Napoli, Not set
AOU Maggiore della Carita, Novara, Not set
Istituto Oncologico Veneto - IRCCS, Padova, Not set
S.O.C Oncologia Medica, Nuovo Ospedale di Prato Santo Stefano, Prato, Not set
Policlinico di Roma, Roma, Not set
Fondazione Policlinico Universitario Agostino Geme, Rome, Not set
Azienda Ospedaliera Universitaria Senese - Losped, Siena, Not set
Aichi Cancer Center Hospital, Aichi, Not set
Tohoku University Hospital, Aoba-ku, Not set
Juntendo University Hospital, Bunkyo-ku, Not set
Chiba Cancer Center, Chuo-ku, Not set
Osaka Prefectural Hospital Organization Osaka International Cancer Institute, Chuo-ku, Not set
NHO Shikoku Cancer Center, Ehime, Not set
Fukushima Medical University Hospital, Fukushima, Not set
Saitama Cancer Center, Inamachi, Not set
Hakuaikai Sagara Hospital, Kagoshima-shi, Not set
Tokai University Hospital, Kanagawa, Not set
National Cancer Center Hospital East, Kashiwa, Not set
The Cancer Institute Hospital of JFCR, Koto-ku, Not set
Kumamoto University Hospital, Kumamoto- shi, Not set
Kure Medical Center And Chugoku Cancer Center, Kure, Not set
Mie University Hospital, Mie, Not set
Nagoya University Hospital, Nagoya, Not set
Nagoya City University Hospital, Nagoya, Not set
Hiroshima City Hiroshima Citizens Hospital, Naka-ku, Not set
NIigata Cancer Center Hospital, Niigata-shi, Not set
Okayama University Hospital, Okayama, Not set
Gunma Prefectural Cancer Center, Ota, Not set
Kyoto University Hospital, Sakyo-ku, Not set
Hokkaido Cancer Center, Sapporo, Not set
Shizuoka General Hospital, Shizuoka-city, Not set
Shizuoka Cancer Center, Shizuoka, Not set
Osaka University Hospital, Suita, Not set
Showa University Hospital, Tokyo, Not set
Kanagawa Cancer Center, Yokohama, Not set
National Cancer Center - Korea, Goyang-si Gyeonggi-do, Not set
Seoul National University Bundang Hospital, Seongnam-si, Not set
Severance Hospital, Seoul, Not set
Asan Medical Center, Seoul, Not set
Samsung Medical Center, Seoul, Not set
Korea University Anam Hospital, Seoul, Not set
Seoul National University Hospital, Seoul, Not set
The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Not set
Hospital Pulau Pinang, Georgetown, Not set
Hospital Sultan Ismail, Johor Bahru, Not set
Hospital Kuala Lumpur, Kuala Lumpur, Not set
Pantai Hospital Kuala Lumpur, Kuala Lumpur, Not set
University Malaya Medical Centre (UMMC), Kuala Lumpur, Not set
Institut Kanser Negara, Putrajaya, Not set
Hospital Wanita dan Kanak-Kanak Sabah, Sabah, Not set
Sarawak General Hospital, Sarawak, Not set
Icaro Investigaciones en Medicina S.A. de C.V., Chihuahua, Not set
Cryptex Investigación Clínica, Ciudad de Mexico, Not set
Centro para el Desarrollo de la Medicina, Culiacan, Not set
Panamerican Clinical Research Mexico - Guadalajara, Guadalajara, Not set
Medical Care and Research S.A. de C.V, Merida, Not set
Avix Investigacion Clinica S.C., Monterrey, Not set
Fucam A.C., México, Not set
Oncológico Potosino, San Luis Potosi, Not set
FAICIC Clínical Research, Veracruz, Not set
iBiomed - Investigacion Biomedica para el Desarrol, Zapopan, Not set
Amphia Ziekenhuis - Breda Langendijk, Breda, Not set
Universitair Medisch Centrum Groningen, Groningen, Not set
Medisch Centrum Leeuwarden, Leeuwarden, Not set
Erasmus Medisch Centrum, Rotterdam, Not set
Uniwersyteckie Centrum Kliniczne, Klinika Onkologii i Radioterapii, Gdansk, Not set
Narodowy Instytut Onkologii im. Marii Sklodowskiej, Gliwice, Not set
SP ZOZ Opolskie Centrum Onkologii im. prof. Tadeusza Koszarowskiego, Opole, Not set
Wielkopolskie Centrum Onkologii im. Marii Sklodowskiej-Curie, Poznan, Not set
Mazowiecki Szpital Wojewódzki im. w. Jana Pawa II w, Siedlce, Not set
Wojskowy Instytut Medyczny, Warsaw, Not set
Narodowy Instytut Onkologii im.Marii Marii Sklodowskiejs, Warszawa, Not set
Ponce Medical School Foundation Inc., Ponce, Not set
Hopelands Cancer Centre, Hilton, Not set
The Medical Oncology Centre of Rosebank, Johannesburg, Not set
University of Pretoria, Pretoria, Not set
Hospital Teresa Herrera - Materno Infantil, A Coruña, Not set
Hospital Universitari Dexeus, Barcelona, Not set
Hospital Clinic Barcelona, Barcelona, Not set
Hospital Clínic de Barcelona, Barcelona, Not set
Hospital de la Santa Creu i Sant Pau, Barcelona, Not set
Hospital Universitari Vall d'Hebrón, Barcelona, Not set
Hospital Universitario de Basurto, Bilbo, Not set
Hospital Universitari Arnau de Vilanova, Lleida, Not set
Hospital General Universitario Gregorio Marañón, Madrid, Not set
MD Anderson Cancer Centre Madrid, Madrid, Not set
Hospital Universitario Fundación Jiménez Díaz, Madrid, Not set
Hospital Universitario Virgen de la Victoria, Malaga, Not set
Hospital General Universitario Morales Meseguer, Murcia, Not set
Hospital Unviersitario Virgen del Rocio, Sevilla, Not set
Hospital Universitario Virgen Macarena, Sevilla, Not set
Hospital Universitario de Canarias, Tenerife, Not set
Hospital Clínico Universitario de Valencia, Valencia, Not set
Kantonsspital Baden, Baden, Not set
Kantonsspital Baselland - Standort Liestal, Liestal, Not set
Kantonsspital Sankt Gallen, St. Gallen, Not set
Kantonsspital Winterthur, Winterthur, Not set
Brust-Zentrum Zurich, Zürich, Not set
Changhua Christian Hospital, Changhua, Not set
Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Not set
Taipei Medical University-Shuang Ho Hospital, New Taipei City, Not set
Chi Mei Hospital, Liouying, Tainan City, Not set
National Cheng Kung University Hospital, Tainan, Not set
Taipei Veterans General Hospital, Taipei City, Not set
National Taiwan University Hospital, Taipei, Not set
Linkou Chang Gung Memorial Hospital, Taoyuan, Not set
Baskent Uni. Dr Turgut Noyan Uyg. ve Aras. Merkezi, Adana, Not set
Ankara Il Saglik Mudurlugu SBU Gulhane Egitim Ve A, Ankara, Not set
Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Not set
Memorial Ankara Hastanesi, Ankara, Not set
Hacettepe Üniversitesi Hastanesi, Ankara, Not set
Trakya Universitesi Tip Fakultesi Hastanesi, Edirne, Not set
Istanbul Il Saglik Mudurlugu Goztepe Prof. Dr. Sul, Istanbul, Not set
Medipol Mega Universite Hastanesi, Istanbul, Not set
Ege Universitesi Hastanesi, Izmir, Not set
Medicana International Izmir Hastanesi, İzmir, Not set
Acibadem Maslak Hastanesi, Sariyer, Not set
VKV Amerikan Hastanesi, Sisli, Not set
NHS Lothian, Edinburgh, Not set
Clinical Trials Unit Lvl 0 Cancer Research UK Beatson Institute, Glasgow, Not set
Leeds Teaching Hospitals NHS Trust, Leeds, Not set
: Barts Health NHS Trust, St Hospital, London, Not set
Royal Free London NHS Foundation Trust, London, Not set
Guy's and Saint Thomas' NHS Foundation Trust, London, Not set
University College London Hospitals, London, Not set
Nottingham University Hospitals NHS Trust, Nottingham, Not set
Conditions: Triple Negative Breast Cancer, PD-L1 Positive
A Study of Nivolumab and Ipilimumab Combined With Chemotherapy Compared to Chemotherapy Alone in First Line NSCLC
Completed
The purpose of this study is to determine whether Nivolumab, Ipilimumab combined with chemotherapy is more effective than chemotherapy by itself when treating stage IV NSCLC as the first treatment given for the disease
The purpose of this study is to determine whether Nivolumab, Ipilimumab combined with chemotherapy is more effective than chemotherapy by itself when treating stage IV NSCLC as the first treatment given for the disease Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/06/2024
Locations: Memorial Health Systems, Colorado Springs, Colorado +115 locations
Memorial Health Systems, Colorado Springs, Colorado
Local Institution - 0044, Plainville, Connecticut
Local Institution - 0045, Jacksonville, Florida
Local Institution - 0029, Marietta, Georgia
Local Institution - 0091, Wichita, Kansas
Local Institution - 0004, Lexington, Kentucky
Local Institution - 0105, Detroit, Michigan
Local Institution - 0058, Johnson City, New York
Local Institution - 0098, Mineola, New York
Local Institution - 0095, Columbus, Ohio
Local Institution - 0006, Lancaster, Pennsylvania
Local Institution - 0047, Pittsburgh, Pennsylvania
Local Institution - 0093, Pittsburgh, Pennsylvania
Local Institution - 0094, Charleston, South Carolina
Southwest Regional Cancer Clinic, Saint George, Utah
Local Institution - 0099, Madison, Wisconsin
Local Institution - 0014, Ciudad Autónoma de Buenos Aires, Buenos Aires
Local Institution - 0028, Rio Cuarto, Cordoba
Local Institution - 0026, Viedma, Rio Negro
Local Institution - 0027, Rosario, Santa Fe
Local Institution - 0030, Cordoba, Not set
Local Institution - 0086, Gosford, New South Wales
Local Institution - 0040, Bedford Park, South Australia
Local Institution - 0089, Box Hill, Victoria
Local Institution - 0036, Heidelberg, Victoria
Local Institution - 0078, Murdoch, Western Australia
Local Institution - 0002, Gilly, Not set
Local Institution - 0033, Leuven, Not set
Local Institution - 0001, Roeselare, Not set
Local Institution - 0068, Natal, RIO Grande DO Norte
Local Institution - 0063, Ijui, Rio Grande Do Sul
Local Institution - 0067, Porto Alegre, Rio Grande Do Sul
Local Institution - 0069, Blumenau, Santa Catarina
Local Institution - 0064, Barretos, Sao Paulo
Local Institution - 0065, Sao Jose Do Rio Preto, Sao Paulo
Local Institution - 0066, Rio De Janeiro, Not set
Local Institution - 0070, São Paulo, Not set
Local Institution - 0090, Montreal, Quebec
Local Institution - 0083, Montreal, Quebec
Local Institution - 0082, Montreal, Quebec
Local Institution - 0080, Rimouski, Quebec
Local Institution - 0084, Santiago, Metropolitana
Local Institution - 0059, Santiago, Región Metropolitana De Santiago
Local Institution - 0079, Vina Del Mar, Valparaiso
Local Institution - 0139, Beijing, BEI
Local Institution - 0146, Haikou, Hainan
Local Institution - 0148, Zhengzhou, Henan
Local Institution - 0120, Zhengzhou, Henan
Local Institution - 0144, Changsha, Hunan
Local Institution - 0106, Changchun, Jilin
Local Institution - 0108, Xi'an City, Shan3xi
Local Institution - 0110, Hangzhou, Zhejiang
Local Institution - 0111, Zhejiang, Zhejiang
Local Institution - 0113, Beijing, Not set
Local Institution - 0112, Shanghai, Not set
Local Institution - 0010, Bron, Rhone Alpes
Local Institution - 0009, Lyon Cedex08, Rhône-Alpes
Local Institution - 0013, Caen, Not set
Local Institution - 0071, Lille Cedex, Not set
Local Institution - 0012, Montpellier, Not set
Local Institution - 0035, Nantes, Not set
Local Institution - 0011, Paris Cedex 20, Not set
Local Institution - 0097, Saint-Brieuc, Not set
Local Institution - 0073, Berlin, Not set
Local Institution - 0016, Gauting, Not set
Local Institution - 0072, Grosshansdorf, Not set
Local Institution - 0019, Hemer, Not set
Local Institution - 0017, Immenhausen, Not set
Local Institution - 0074, Magdeburg, Not set
Local Institution - 0015, Muenchen, Not set
Local Institution - 0018, Stuttgart, Not set
Local Institution - 0021, Dublin, Not set
Local Institution - 0020, Limerick, Not set
Local Institution - 0042, Lucca, Not set
Local Institution - 0041, Milano, Not set
Local Institution - 0043, Napoli, Not set
Local Institution - 0101, Fukushima-shi, Fukushima
Local Institution - 0118, Maebashi-shi, Gunma
Local Institution - 0128, Ota-shi, Gunma
Local Institution - 0138, Hiroshima-shi, Hiroshima
Local Institution - 0137, Hiroshima-shi, Hiroshima
Local Institution - 0127, Sapporo-shi, Hokkaido
Local Institution - 0131, Akashi-shi, Hyogo
Local Institution - 0119, Himeji-shi, Hyogo
Local Institution - 0104, Kobe-shi, Hyogo
Local Institution - 0115, Kanazawa-shi, Ishikawa
Local Institution - 0100, Shiwa-gun, Iwate
Local Institution - 0129, Yokohama-shi, Kanagawa
Local Institution - 0114, Yokohama-Shi, Kanagawa
Local Institution - 0134, Yokohama-shi, Kanagawa
Local Institution - 0116, Niigata-shi, Niigata
Local Institution - 0136, Okayama-shi, Okayama
Local Institution - 0135, Habikino-shi, Osaka
Local Institution - 0103, Osaka-Sayama, Osaka
Local Institution - 0102, Kitaadachi-gun, Saitama
Local Institution - 0132, Ube-shi, Yamaguchi
Local Institution - 0130, Osaka, Not set
Local Institution - 0077, La Paz, BAJA Californa SUR
Local Institution - 0061, Guadalajara, Jalisco
Local Institution - 0075, Veracruz, Veracruz, Not set
Local Institution - 0087, Bydgoszcz, Not set
Local Institution - 0022, Bytom, Not set
Local Institution - 0085, Gdańsk, Not set
Local Institution - 0034, Bucharest, Not set
Local Institution - 0031, Cluj Napoca, Not set
Local Institution - 0032, Craiova, Not set
Local Institution - 0024, Moscow, Not set
Local Institution - 0025, St.petersburg, Not set
Local Institution - 0054, A Coruña, Not set
Local Institution - 0053, Barcelona, Not set
Local Institution - 0052, Madrid, Not set
Local Institution - 0055, Malaga, Not set
Local Institution - 0056, Valencia, Not set
Local Institution - 0050, Guildford, Not set
Local Institution - 0049, London, Not set
Local Institution - 0048, Tauton, Not set
Conditions: Non-Small Cell Lung Cancer
Safety and Pharmacokinetics (PK) of Escalating Doses of Tiragolumab as a Single Agent and in Combination With Atezolizumab and/or Other Anti-Cancer Therapies in Locally Advanced or Metastatic Tumors
Completed
This first-in-human open-label, multicenter, dose-escalation and expansion study is designed to evaluate the safety, tolerability, and PK of tiragolumab alone or in combination with atezolizumab and/or other anti-cancer therapies in participants with locally advanced, recurrent, or metastatic incurable tumors for whom standard therapy does not exist, has proven to be ineffective or intolerable, or is considered inappropriate, or for whom a clinical trial of an investigational agent is a recogniz... Read More
This first-in-human open-label, multicenter, dose-escalation and expansion study is designed to evaluate the safety, tolerability, and PK of tiragolumab alone or in combination with atezolizumab and/or other anti-cancer therapies in participants with locally advanced, recurrent, or metastatic incurable tumors for whom standard therapy does not exist, has proven to be ineffective or intolerable, or is considered inappropriate, or for whom a clinical trial of an investigational agent is a recognized standard of care. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/04/2024
Locations: Honor Health Research Institute, Scottsdale, Arizona +27 locations
Honor Health Research Institute, Scottsdale, Arizona
University of California Los Angeles, Santa Monica, California
Yale Cancer Center, New Haven, Connecticut
Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland
Dana Farber Cancer Institute, Boston, Massachusetts
Henry Ford Hospital, Detroit, Michigan
Memorial Sloan-Kettering Cancer Center, New York, New York
Tennessee Oncology - Nashville, Nashville, Tennessee
Kinghorn Cancer Centre; St Vincents Hospital, Darlinghurst, New South Wales
Peter MacCallum Cancer Center, North Melbourne, Victoria
Princess Margaret Hospital, Toronto, Ontario
Institut Bergonie CLCC Bordeaux, Bordeaux, Not set
Centre Léon Bérard Centre Régional de Lutte Contre Le Cancer Rhône Alpes, Lyon, Not set
Institut Curie, Paris, Not set
Institut Claudius Regaud; Departement Oncologie Medicale, Toulouse, Not set
Institut Gustave Roussy, Villejuif, Not set
National Cancer Center Hospital, Tokyo, Not set
The Cancer Institute Hospital of Japanese Foundation For Cancer Research, Tokyo, Not set
Seoul National University Hospital, Seoul, Not set
Severance Hospital, Yonsei University Health System, Seoul, Not set
Asan Medical Center, Seoul, Not set
Samsung Medical Center, Seoul, Not set
ICO L'Hospitalet; Servicio de oncologia medica, L'Hospitalet de Llobregat, Barcelona
Hospital Univ Vall d'Hebron; Servicio de Oncologia, Sant Andreu de La Barca, Barcelona
Clinica Universitaria de Navarra; Servicio de oncología, Pamplona, Navarra
Hospital del Mar, Barcelona, Not set
Hospital Universitario HM Sanchinarro-CIOCC; Oncología Médica, Madrid, Not set
Hospital Clinico Universitario de Valencia, Valencia, Not set
Conditions: Advanced/Metastatic Tumors
Pembrolizumab With Chemotherapy and MK-4830 for Treating Participants With Ovarian Cancer (MK-4830-002)
Completed
The primary objective is to evaluate in participants with high-grade serous ovarian cancer (HGSOC), whether the reduction from baseline in circulating tumor DNA (ctDNA) at Cycle 3 (ΔctDNA) is larger in participants receiving MK-4830 + pembrolizumab in combination with standard of care (SOC) therapy than in those receiving pembrolizumab + SOC therapy.
The primary objective is to evaluate in participants with high-grade serous ovarian cancer (HGSOC), whether the reduction from baseline in circulating tumor DNA (ctDNA) at Cycle 3 (ΔctDNA) is larger in participants receiving MK-4830 + pembrolizumab in combination with standard of care (SOC) therapy than in those receiving pembrolizumab + SOC therapy. Read Less
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
11/27/2024
Locations: University of Colorado Anschutz Medical Campus-Cancer Clinical Trials Office ( Site 0108), Aurora, Colorado +44 locations
University of Colorado Anschutz Medical Campus-Cancer Clinical Trials Office ( Site 0108), Aurora, Colorado
Mayo Clinic in Florida ( Site 0101), Jacksonville, Florida
Miami Cancer Institute at Baptist Health, Inc. ( Site 0110), Miami, Florida
Northwestern Memorial Hospital ( Site 0104), Chicago, Illinois
Washington University ( Site 0113), Saint Louis, Missouri
Rutgers Cancer Institute of New Jersey ( Site 0114), New Brunswick, New Jersey
Roswell Park Cancer Institute ( Site 0106), Buffalo, New York
Perlmutter Cancer Center at NYU Langone Hospital - Long Island ( Site 0116), Mineola, New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone ( Site 0107), New York, New York
Memorial Sloan Kettering Cancer Center ( Site 0102), New York, New York
Sanford Cancer Center-Gynecologic Oncology ( Site 0115), Sioux Falls, South Dakota
Fred Hutchinson Cancer Center ( Site 0100), Seattle, Washington
Antwerp University Hospital-Oncology ( Site 1301), Edegem, Antwerpen
AZ Maria Middelares-IKG ( Site 1302), Gent, Oost-Vlaanderen
UZ Leuven ( Site 1300), Leuven, Vlaams-Brabant
Centre Hospitalier de l'Université de Montréal ( Site 0300), Montréal, Quebec
McGill University Health Centre ( Site 0301), Montréal, Quebec
James Lind Centro de Investigación del Cáncer ( Site 0903), Temuco, Araucania
FALP ( Site 0905), Santiago, Region M. De Santiago
Pontificia Universidad Catolica de Chile-Centro del Cáncer ( Site 0900), Santiago, Region M. De Santiago
ONCOCENTRO APYS-ACEREY ( Site 0904), Viña del Mar, Valparaiso
Rambam Health Care Campus-Gyneco-oncology unit ( Site 0602), Haifa, Not set
Shaare Zedek Medical Center ( Site 0601), Jerusalem, Not set
Sheba Medical Center-ONCOLOGY ( Site 0600), Ramat Gan, Not set
Istituto Nazionale Tumori IRCCS Fondazione Pascale-S.C. Oncologia Sperimentale Uro-Genitale ( Site 0, Napoli, Campania
Fondazione Policlinico Universitario Agostino Gemelli-Ginecologia Oncologica ( Site 0502), Roma, Lazio
Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Chirurgia Ginecologica ( Site 050, Milan, Lombardia
Istituto Europeo di Oncologia IRCCS-Divisione di Ginecologia Oncologica ( Site 0501), Milano, Not set
Seoul National University Hospital ( Site 0801), Seoul, Not set
Severance Hospital, Yonsei University Health System-Gynecologic cancer center ( Site 0800), Seoul, Not set
Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 0701), Siedlce, Mazowieckie
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Ginekologii Onkologicznej ( Sit, Warszawa, Mazowieckie
Uniwersyteckie Centrum Kliniczne-Klinika Ginekologii, Ginekologii Onkologicznej i Endokrynologii Gi, Gdańsk, Pomorskie
Swietokrzyskie Centrum Onkologii, Samodzielny Publiczny Zaklad Opieki Zdrowotnej ( Site 0708), Kielce, Swietokrzyskie
Uniwersytecki Szpital Kliniczny w Poznaniu-Oddzial Ginekologii Onkologicznej ( Site 0709), Poznan, Wielkopolskie
National Cancer Centre Singapore ( Site 1501), Singapore, Central Singapore
National University Hospital ( Site 1502), Singapore, South West
Instituto Catalan de Oncologia - Hospital Duran i Reynals-Medical Oncology ( Site 1103), Hospitalet, Barcelona
Hospital Universitario 12 de Octubre-Medical Oncology ( Site 1104), Madrid, Madrid, Comunidad De
Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 1101), Barcelona, Not set
Changhua Christian Hospital-Obstetrics and Gynecology ( Site 1203), Changhua County, Changhua
Taichung Veterans General Hospital-GYNECOLOGY ( Site 1202), Taichung, Not set
National Cheng Kung University Hospital ( Site 1201), Tainan, Not set
National Taiwan University Hospital-Internal Medicine ( Site 1200), Taipei, Not set
Mackay Memorial Hospital ( Site 1204), Taipei, Not set
Conditions: High-grade Serous Ovarian Carcinoma, Ovarian Carcinoma
A Study to Evaluate Dostarlimab Plus Carboplatin-paclitaxel Versus Placebo Plus Carboplatin-paclitaxel in Participants With Recurrent or Primary Advanced Endometrial Cancer
Active Not Recruiting
This is a 2 part study. Part 1 is to evaluate the efficacy and safety of dostarlimab plus carboplatin-paclitaxel followed by dostarlimab versus placebo plus carboplatin-paclitaxel followed by placebo; and Part 2 is to evaluate the efficacy and safety of dostarlimab plus carboplatin-paclitaxel followed by dostarlimab plus niraparib versus placebo plus carboplatin-paclitaxel followed by placebo in participants with recurrent or primary advanced (Stage III or IV) endometrial cancer.
This is a 2 part study. Part 1 is to evaluate the efficacy and safety of dostarlimab plus carboplatin-paclitaxel followed by dostarlimab versus placebo plus carboplatin-paclitaxel followed by placebo; and Part 2 is to evaluate the efficacy and safety of dostarlimab plus carboplatin-paclitaxel followed by dostarlimab plus niraparib versus placebo plus carboplatin-paclitaxel followed by placebo in participants with recurrent or primary advanced (Stage III or IV) endometrial cancer. Read Less
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
11/26/2024
Locations: GSK Investigational Site, Phoenix, Arizona +168 locations
GSK Investigational Site, Phoenix, Arizona
GSK Investigational Site, Scottsdale, Arizona
GSK Investigational Site, Tempe, Arizona
GSK Investigational Site, Tucson, Arizona
GSK Investigational Site, Tucson, Arizona
GSK Investigational Site, Newport Beach, California
GSK Investigational Site, Palo Alto, California
GSK Investigational Site, Deerfield Beach, Florida
GSK Investigational Site, Jacksonville, Florida
GSK Investigational Site, Miami, Florida
GSK Investigational Site, Miami, Florida
GSK Investigational Site, Orlando, Florida
GSK Investigational Site, Augusta, Georgia
GSK Investigational Site, Savannah, Georgia
GSK Investigational Site, Savannah, Georgia
GSK Investigational Site, Hinsdale, Illinois
GSK Investigational Site, Zion, Illinois
GSK Investigational Site, Fort Wayne, Indiana
GSK Investigational Site, Indianapolis, Indiana
GSK Investigational Site, Indianapolis, Indiana
GSK Investigational Site, Iowa City, Iowa
GSK Investigational Site, Lexington, Kentucky
GSK Investigational Site, Covington, Louisiana
GSK Investigational Site, New Orleans, Louisiana
GSK Investigational Site, Shreveport, Louisiana
GSK Investigational Site, Boston, Massachusetts
GSK Investigational Site, Springfield, Massachusetts
GSK Investigational Site, Detroit, Michigan
GSK Investigational Site, Saint Louis, Missouri
GSK Investigational Site, Lebanon, New Hampshire
GSK Investigational Site, Albuquerque, New Mexico
GSK Investigational Site, Rio Rancho, New Mexico
GSK Investigational Site, Albany, New York
GSK Investigational Site, Bronx, New York
GSK Investigational Site, Mineola, New York
GSK Investigational Site, New York, New York
GSK Investigational Site, Charlotte, North Carolina
GSK Investigational Site, Durham, North Carolina
GSK Investigational Site, Kernersville, North Carolina
GSK Investigational Site, Mount Airy, North Carolina
GSK Investigational Site, Winston-Salem, North Carolina
GSK Investigational Site, Cincinnati, Ohio
GSK Investigational Site, Cincinnati, Ohio
GSK Investigational Site, Cleveland, Ohio
GSK Investigational Site, Columbus, Ohio
GSK Investigational Site, Hilliard, Ohio
GSK Investigational Site, Tulsa, Oklahoma
GSK Investigational Site, Philadelphia, Pennsylvania
GSK Investigational Site, Pittsburgh, Pennsylvania
GSK Investigational Site, Wexford, Pennsylvania
GSK Investigational Site, Willow Grove, Pennsylvania
GSK Investigational Site, Providence, Rhode Island
GSK Investigational Site, Knoxville, Tennessee
GSK Investigational Site, Austin, Texas
GSK Investigational Site, Dallas, Texas
GSK Investigational Site, Fort Worth, Texas
GSK Investigational Site, Charlottesville, Virginia
GSK Investigational Site, Roanoke, Virginia
GSK Investigational Site, Seattle, Washington
GSK Investigational Site, Grodno, Not set
GSK Investigational Site, Minsk, Not set
GSK Investigational Site, Aalst, Not set
GSK Investigational Site, Leuven, Not set
GSK Investigational Site, LiEge, Not set
GSK Investigational Site, Calgary, Alberta
GSK Investigational Site, Winnipeg, Manitoba
GSK Investigational Site, Ottawa, Ontario
GSK Investigational Site, Sault Ste Marie, Ontario
GSK Investigational Site, Toronto, Ontario
GSK Investigational Site, Montreal, Quebec
GSK Investigational Site, Montreal, Quebec
GSK Investigational Site, QuEbec, Not set
GSK Investigational Site, Brno, Not set
GSK Investigational Site, Praha 2, Not set
GSK Investigational Site, Aalborg, Not set
GSK Investigational Site, Copenhagen, Not set
GSK Investigational Site, Herlev, Not set
GSK Investigational Site, Odense C, Not set
GSK Investigational Site, Roskilde, Not set
GSK Investigational Site, Kuopio, Not set
GSK Investigational Site, Tampere, Not set
GSK Investigational Site, Turku, Not set
GSK Investigational Site, Amberg, Not set
GSK Investigational Site, Bad Homburg, Not set
GSK Investigational Site, Dessau, Not set
GSK Investigational Site, Dresden, Not set
GSK Investigational Site, Essen, Not set
GSK Investigational Site, Essen, Not set
GSK Investigational Site, Frankfurt, Not set
GSK Investigational Site, Giessen, Not set
GSK Investigational Site, Hamburg, Not set
GSK Investigational Site, Hannover, Not set
GSK Investigational Site, Jena, Not set
GSK Investigational Site, Karlsruhe, Not set
GSK Investigational Site, Kiel, Not set
GSK Investigational Site, Koeln, Not set
GSK Investigational Site, Luebeck, Not set
GSK Investigational Site, Mainz, Not set
GSK Investigational Site, Muenchen, Not set
GSK Investigational Site, Offenbach, Not set
GSK Investigational Site, Ravensburg, Not set
GSK Investigational Site, Rosenheim, Not set
GSK Investigational Site, Tuebingen, Not set
GSK Investigational Site, Ulm, Not set
GSK Investigational Site, Wiesbaden, Not set
GSK Investigational Site, Marousi, Not set
GSK Investigational Site, Thessaloniki, Not set
GSK Investigational Site, Budapest, Not set
GSK Investigational Site, Debrecen, Not set
GSK Investigational Site, Ashkelon, Not set
GSK Investigational Site, Beer-Sheva, Not set
GSK Investigational Site, Haifa, Not set
GSK Investigational Site, Jerusalem, Not set
GSK Investigational Site, Petach Tikva, Not set
GSK Investigational Site, Rehovot, Not set
GSK Investigational Site, Tel Aviv, Not set
GSK Investigational Site, Biella, Not set
GSK Investigational Site, Candiolo, Not set
GSK Investigational Site, Carpi MO, Not set
GSK Investigational Site, Lecce, Not set
GSK Investigational Site, Milano, Not set
GSK Investigational Site, Naples, Not set
GSK Investigational Site, Rome, Not set
GSK Investigational Site, Sassuolo, Not set
GSK Investigational Site, Trento, Not set
GSK Investigational Site, Udine, Not set
GSK Investigational Site, Amsterdam, Not set
GSK Investigational Site, Eindhoven, Not set
GSK Investigational Site, Enschede, Not set
GSK Investigational Site, Groningen, Not set
GSK Investigational Site, Maastricht, Not set
GSK Investigational Site, Rotterdam, Not set
GSK Investigational Site, Bergen, Not set
GSK Investigational Site, Oslo, Not set
GSK Investigational Site, Stavanger, Not set
GSK Investigational Site, Troms, Not set
GSK Investigational Site, Trondheim, Not set
GSK Investigational Site, Bialystok, Not set
GSK Investigational Site, Gdynia, Not set
GSK Investigational Site, Lodz, Not set
GSK Investigational Site, Olsztyn, Not set
GSK Investigational Site, Poznan, Not set
GSK Investigational Site, Szczecin, Not set
GSK Investigational Site, Warszawa, Not set
GSK Investigational Site, Barcelona, Not set
GSK Investigational Site, Barcelona, Not set
GSK Investigational Site, Madrid, Not set
GSK Investigational Site, Madrid, Not set
GSK Investigational Site, MAlaga, Not set
GSK Investigational Site, MAlaga, Not set
GSK Investigational Site, Murcia, Not set
GSK Investigational Site, San SebastiAn, Not set
GSK Investigational Site, Valencia, Not set
GSK Investigational Site, Linkoping, Not set
GSK Investigational Site, Lund, Not set
GSK Investigational Site, Stockholm, Not set
GSK Investigational Site, Uppsala, Not set
GSK Investigational Site, Adapazari, Not set
GSK Investigational Site, Ankara, Not set
GSK Investigational Site, Istanbul, Not set
GSK Investigational Site, Istanbul, Not set
GSK Investigational Site, Istanbul, Not set
GSK Investigational Site, Chernihiv, Not set
GSK Investigational Site, Kharkiv, Not set
GSK Investigational Site, Brighton, Not set
GSK Investigational Site, Cambridge, Not set
GSK Investigational Site, London, Not set
GSK Investigational Site, London, Not set
GSK Investigational Site, Truro, Not set
Conditions: Neoplasms
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