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Carboplatin Treatment Options in Canada
A collection of 336 research studies where Carboplatin is the interventional treatment. These studies are located in the Canada . Carboplatin is used for conditions such as Non-Small Cell Lung Cancer, Ovarian Cancer and Lung Cancer.
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Study of Pembrolizumab With Concurrent Chemoradiation Therapy Followed by Pembrolizumab With or Without Olaparib in Stage III Non-Small Cell Lung Cancer (NSCLC) (MK-7339-012/KEYLYNK-012)
Active Not Recruiting
The purpose of this study is to assess the efficacy and safety of pembrolizumab in combination with concurrent chemoradiation therapy followed by either pembrolizumab with olaparib placebo (Arm 1) or with olaparib (Arm 2) compared to concurrent chemoradiation therapy followed by durvalumab (Arm 3) in participants with unresectable, locally advanced NSCLC. Arms 1 and 2 will be studied in a double-blind design and Arm 3 will be open-label. The primary hypotheses are:
1. Pembrolizumab with concurr... Read More
The purpose of this study is to assess the efficacy and safety of pembrolizumab in combination with concurrent chemoradiation therapy followed by either pembrolizumab with olaparib placebo (Arm 1) or with olaparib (Arm 2) compared to concurrent chemoradiation therapy followed by durvalumab (Arm 3) in participants with unresectable, locally advanced NSCLC. Arms 1 and 2 will be studied in a double-blind design and Arm 3 will be open-label. The primary hypotheses are:
1. Pembrolizumab with concurrent chemoradiation therapy followed by pembrolizumab with olaparib is superior to concurrent chemoradiation therapy followed by durvalumab with respect to progression-free survival (PFS) and overall survival (OS)
2. Pembrolizumab with concurrent chemoradiation therapy followed by pembrolizumab is superior to concurrent chemoradiation therapy followed by durvalumab with respect to PFS and OS Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/15/2024
Locations: University of South Alabama, Mitchell Cancer Institute ( Site 0003), Mobile, Alabama +204 locations
University of South Alabama, Mitchell Cancer Institute ( Site 0003), Mobile, Alabama
St. Bernards Medical Center ( Site 0089), Jonesboro, Arkansas
St Joseph Heritage Healthcare-Oncology ( Site 0088), Fullerton, California
Long Beach Memorial Medical Center ( Site 0006), Long Beach, California
UCLA Hematology/Oncology - Santa Monica ( Site 0013), Los Angeles, California
St. Joseph Heritage Healthcare Local Lab ( Site 0011), Santa Rosa, California
Torrance Memorial Physician Network / Cancer Center ( Site 0093), Torrance, California
Memorial Regional Hospital-Memorial Cancer Institute ( Site 0095), Hollywood, Florida
Miami VA Healthcare System ( Site 0024), Miami, Florida
Mid Florida Hematology and Oncology Center ( Site 0022), Orange City, Florida
Orlando Health, UF Health Cancer Center Inc ( Site 0092), Orlando, Florida
Fort Wayne Medical Oncology and Hematology ( Site 0094), Fort Wayne, Indiana
Parkview Research Center ( Site 0032), Fort Wayne, Indiana
Franciscan Health Lafayette East ( Site 0031), Lafayette, Indiana
University of Kentucky ( Site 0096), Lexington, Kentucky
Norton Brownsboro Hospital-Norton Cancer Institute - Brownsboro ( Site 0035), Louisville, Kentucky
Pikeville Medical Center ( Site 0036), Pikeville, Kentucky
Massachusetts General Hospital ( Site 0038), Boston, Massachusetts
Henry Ford Hospital ( Site 0045), Detroit, Michigan
VA St. Louis Health Care System ( Site 0047), Saint Louis, Missouri
Washington University Siteman Cancer Center ( Site 0046), Saint Louis, Missouri
CHI Health St. Francis ( Site 0053), Grand Island, Nebraska
Rutgers Cancer Institute of New Jersey ( Site 0054), New Brunswick, New Jersey
The Valley Hospital ( Site 0056), Paramus, New Jersey
Montefiore Einstein Center ( Site 0083), Bronx, New York
Novant Health Presbyterian ( Site 0081), Charlotte, North Carolina
Duke University Medical Center ( Site 0050), Durham, North Carolina
Piedmont Hematology-Oncology Associates ( Site 0080), Winston-Salem, North Carolina
The Lindner Center for Research and Education at The Christ Hospital ( Site 0060), Cincinnati, Ohio
Fox Chase Cancer Center ( Site 0063), Philadelphia, Pennsylvania
Sanford Cancer Center Oncology Clinic ( Site 0066), Sioux Falls, South Dakota
Veterans Affairs Puget Sound Health Care System [Seattle, WA] ( Site 0075), Seattle, Washington
Cancer Care Northwest ( Site 0074), Spokane Valley, Washington
Instituto Médico Río Cuarto ( Site 4003), Río Cuarto, Cordoba
Clinica Adventista Belgrano-Oncology ( Site 4002), Caba, Not set
Queen Elizabeth II Health Sciences Centre ( Site 0100), Halifax, Nova Scotia
Centre Hospitalier de l Universite de Montreal - CHUM ( Site 0102), Montreal, Quebec
CIUSSS Ouest de l Ile - St-Mary s Hospital ( Site 0108), Montreal, Quebec
McGill University Health Center - Research Institute ( Site 0114), Montreal, Quebec
Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 0, Quebec, Not set
Centro Investigación del Cáncer James Lind ( Site 0202), Temuco, Araucania
OrlandiOncologia ( Site 0201), Santiago, Region M. De Santiago
Bradfordhill ( Site 0200), Santiago, Region M. De Santiago
Oncocentro ( Site 0203), Vina del Mar, Valparaiso
Bradford Hill Norte ( Site 0204), Antofagasta, Not set
Beijing Cancer Hospital ( Site 3224), Beijing, Beijing
Peking Union Medical College Hospital ( Site 3201), Beijing, Beijing
Cancer Hospital Chinese Academy of Medical Sciences ( Site 3213), Beijing, Beijing
Beijing Cancer Hospital ( Site 3212), Beijing, Beijing
Daping Hospital,Third Military Medical University ( Site 3235), Chongqing, Chongqing
Fujian Provincial Cancer Hospital ( Site 3226), Fuzhou, Fujian
The First Affiliated Hospital of Xiamen University ( Site 3219), Xiamen, Fujian
Peking University Shenzhen Hospital ( Site 3216), Shenzhen, Guangdong
Cancer Hospital Chinese Academy Of Medical Sciences. Shenzhen Center ( Site 3200), Shenzhen, Guangdong
Henan Cancer Hospital ( Site 3205), Zhengzhou, Henan
Wuhan Union Hospital ( Site 3222), Wuhan, Hubei
Hubei Cancer Hospital ( Site 3218), Wuhan, Hubei
Hunan Cancer Hospital ( Site 3238), Changsha, Hunan
Xiangya Hospital of Central South University ( Site 3637), Changsha, Hunan
Second Xiangya Hospital of Central-South University ( Site 3227), Changsha, Hunan
Hunan Cancer Hospital ( Site 3225), Changsha, Hunan
Jiangsu Cancer Hospital ( Site 3234), Nanjing, Jiangsu
The Second Affiliated Hospital of Nanchang University ( Site 3206), Nanchang, Jiangxi
Jilin Cancer Hospital ( Site 3230), Changchun, Jilin
Shanghai Chest Hospital ( Site 3207), Shangai, Shanghai
Zhongshan Hospital Fudan University ( Site 3220), Shanghai, Shanghai
Shanghai Pulmonary Hospital ( Site 3203), Shanghai, Shanghai
West China Hospital of Sichuan University ( Site 3202), Chengdu, Sichuan
Tianjin Medical University Cancer Institute & Hospital ( Site 3204), Tianjin, Tianjin
The 1st Affil Hosp of College of Medicine, Zhejiang Univ ( Site 3232), Hangzhou, Zhejiang
Masarykuv onkologicky ustav ( Site 2206), Brno, Brno-mesto
Fakultni nemocnice Ostrava ( Site 2201), Ostrava, Ostrava Mesto
Fakultni nemocnice Kralovske Vinohrady-Radioterapeuticka a onkologicka klinika ( Site 2200), PRague, Praha 10
Fakultni nemocnice v Motole ( Site 2210), Praha, Praha, Hlavni Mesto
Nemocnice Na Plesi s.r.o. ( Site 2202), Nova Ves pod Plesi, Pribram
Krajska nemocnice Liberec, a.s. ( Site 2209), Liberec, Not set
Vseobecna fakultni nemocnice v Praze ( Site 2208), Praha 2, Not set
Nemocnice Na Bulovce ( Site 2205), Praha 8, Not set
North Estonia Medical Centre Foundation ( Site 1601), Tallin, Harjumaa
Tartu University Hospital ( Site 1600), Tartu, Tartumaa
Clinique Clairval ( Site 0802), Marseille, Bouches-du-Rhone
C.H.R.U. de Brest - Hopital Morvan ( Site 0806), Brest, Bretagne
Centre Hospitalier Annecy Genevois ( Site 0811), Epagny Metz Tessy, Haute-Savoie
Clinique Teissier Groupe ( Site 0808), Valenciennes, Nord
Hopital Avicenne ( Site 0803), Bobigny, Seine-Saint-Denis
Clinique de l'Europe-Service de pneumologie ( Site 0816), Amiens, Somme
H.I.A. Sainte-Anne ( Site 0815), Toulon, Var
CHD Vendee ( Site 0807), La Roche sur Yon, Vendee
Universitätsmedizin Göttingen - Georg-August-Universität ( Site 0917), Göttingen, Niedersachsen
Johannes Wesling Klinikum Minden ( Site 0908), Minden, Nordrhein-Westfalen
GEHO Muenster ( Site 0910), Muenster, Nordrhein-Westfalen
Johanna Etienne Hospital-Klinik für Onkologie ( Site 0916), Neuss, Nordrhein-Westfalen
LungenClinic Grosshansdorf GmbH ( Site 0901), Grosshansdorf, Schleswig-Holstein
Zentralklinik Bad Berka GmbH ( Site 0905), Bad Berka, Thuringen
Universitaetsklinikum Jena ( Site 0911), Jena, Thuringen
Charite-Universitaetsmedizin Berlin Campus Virchow-Klinikum ( Site 0900), Berlin, Not set
Katholisches Marienkrankenhaus gGmbH ( Site 0902), Hamburg, Not set
Bacs-Kiskun Megyei Korhaz-Onkoradiologiai Kozpont ( Site 2302), Kecskemét, Bacs-Kiskun
Bekes Megyei Kozponti Korhaz - Pandy Kalman Tagkorhaza ( Site 2303), Gyula, Bekes
Petz Aladar Megyei Oktato Korhaz ( Site 2306), Gyor, Gyor-Moson-Sopron
Orszagos Koranyi Pulmonologiai Intezet ( Site 2305), Budapest, Not set
Országos Korányi Pulmonológiai Intézet-VI. Tüdöbelosztály és Bronchológia ( Site 2309), Budapest, Not set
Azienda Ospedaliera Umberto I- Torrette ( Site 1009), Torrette, Ancona
Azienda Ospedaliero Universitaria Careggi ( Site 1001), Florence, Firenze
Istituto Clinico Humanitas Research Hospital ( Site 1000), Rozzano, Lombardia
Azienda Ospedaliera Vito Fazzi ( Site 1003), Lecce, Not set
Fondazione IRCCS Istituto Nazionale dei Tumori di Milano ( Site 1008), Milano, Not set
Policlinico di Modena ( Site 1007), Modena, Not set
Policlinico Agostino Gemelli ( Site 1002), Roma, Not set
A.O.U. Santa Maria della Misericordia di Udine ( Site 1004), Udine, Not set
Kurume University Hospital ( Site 3112), Kurume, Fukuoka
Kobe Minimally Invasive Cancer Center ( Site 3100), Kobe, Hyogo
Kanagawa Cancer Center ( Site 3101), Yokohama, Kanagawa
Kansai Medical University Hospital ( Site 3103), Hirakata, Osaka
Osaka Medical and Pharmaceutical University Hospital ( Site 3110), Takatsuki, Osaka
National Hospital Organization Kyushu Cancer Center ( Site 3104), Fukuoka, Not set
Niigata Cancer Center Hospital ( Site 3109), Niigata, Not set
Osaka International Cancer Institute ( Site 3106), Osaka, Not set
Juntendo University Hospital ( Site 3111), Tokyo, Not set
Tokyo Metropolitan Komagome Hospital ( Site 3108), Tokyo, Not set
The Cancer Institute Hospital of JFCR ( Site 3107), Tokyo, Not set
Showa University Hospital ( Site 3105), Tokyo, Not set
Chungbuk National University Hospital ( Site 2802), Cheongju-si, Chungbuk
National Cancer Center ( Site 2800), Goyang-si, Kyonggi-do
The Catholic University of Korea St. Vincent s Hospital ( Site 2805), Gyeonggi-do, Kyonggi-do
Seoul National University Bundang Hospital ( Site 2801), Seongnam-si, Kyonggi-do
Ajou University Hospital ( Site 2803), Suwon-si, Kyonggi-do
Gyeongsang National University Hospital ( Site 2804), Jinju-si, Kyongsangnam-do
Keimyung University Dongsan Hospital ( Site 2807), Daegu, Taegu-Kwangyokshi
Kangbuk Samsung Hospital ( Site 2806), Seoul, Not set
Severance Hospital Yonsei University Health System ( Site 2808), Seoul, Not set
Pauls Stradins Clinical University Hospital ( Site 1501), Riga, Not set
Riga East Clinical University Hospital ( Site 1500), Riga, Not set
Hospital of Lithuanian University of Health Sciences Kauno klinikos-Pulmonology ( Site 4201), Kaunas, Kauno Apskritis
National Cancer Institute-Department of Thoracic Surgery and Oncology ( Site 4200), Vilnius, Vilniaus Miestas
Hospital Civil de Guadalajara Fray Antonio Alcalde ( Site 0500), Guadalajara, Jalisco
Hospital Universitario "Dr. Jose Eleuterio Gonzalez" ( Site 0508), Monterrey, Nuevo Leon
CLIMERS Clinical Medical Research ( Site 0506), Orizaba, Veracruz
Instituto Nacional de Cancerologia ( Site 0502), Tlalpan, Not set
Akershus Universitetssykehus HF ( Site 1106), Lorenskog, Akershus
Vestre Viken HF Drammen Sykehus ( Site 1101), Drammen, Buskerud
Sykehuset Oestfold ( Site 1107), Gralum, Ostfold
Helse Stavanger HF Stavanger Universitetssjukehus ( Site 1103), Stavanger, Rogaland
Oslo Universitetssykehus HF. Ulleval ( Site 1100), Oslo, Not set
Hospital Nacional Carlos Alberto Seguin Escobedo ESSALUD ( Site 0604), Arequipa, Ariqipa
Oncosalud ( Site 0605), Lima, Muni Metro De Lima
Detecta Clínica ( Site 0607), Surquillo, Muni Metro De Lima
IPOR Instituto Peruano de Oncología & Radioterapia ( Site 0606), Lima, Not set
Clinica San Gabriel ( Site 0601), Lima, Not set
Hospital Nacional Cayetano Heredia ( Site 0602), Lima, Not set
Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 2404), Siedlce, Mazowieckie
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie (, Warszawa, Mazowieckie
Szpital Morski im. PCK. Szpitale Pomorskie Sp. Z o.o ( Site 2400), Gdynia, Pomorskie
SPZOZ MSWIA z Warminsko-Mazurskim Centrum Onkologii w Olsztynie ( Site 2401), Olsztyn, Warminsko-mazurskie
Spitalul Universitar de Urgenta Bucuresti ( Site 2508), Bucharest, Bucuresti
Gral Medical SRL-Medical Oncology ( Site 2511), București, Bucuresti
Institutul Oncologic Prof.Dr. Ion Chiricuta Cluj-Napoca ( Site 2506), Cluj Napoca, Cluj
S.C. Radiotherapy Center Cluj S.R.L ( Site 2503), Comuna Floresti, Cluj
Centrul de Oncologie "Sfântul Nectarie"-Medical Oncology ( Site 2510), Craiova, Dolj
Radiology Therapeutic Center-Oncology ( Site 2502), Otopeni, Ilfov
Policlinica Oncomed SRL ( Site 2504), Timisoara, Timis
S C Oncocenter Oncologie Clinica S R L-Medical Oncology ( Site 2509), Timișoara, Timis
S.C.Focus Lab Plus S.R.L ( Site 2500), Bucuresti, Not set
Spitalul Clinic Judetean De Urgenta Constanta ( Site 2501), Constanta, Not set
Institutul Regional de Oncologie Iasi ( Site 2505), Iasi, Not set
Chelyabinsk Regional Clinical Oncological Dispensary ( Site 1913), Chelyabinsk, Chelyabinskaya Oblast
MSROI named after P.A. Hertsen branch of FSBI NMRC Radiology ( Site 1903), Moscow, Moskva
Nizhniy Novgorod Region Oncology Dispensary ( Site 1914), Nizhniy Novgorod, Nizhegorodskaya Oblast
Scientific Research Oncology Institute n.a. N.N.Petrov ( Site 1905), Saint-Petersburg, Sankt-Peterburg
Medical institute named after Berezin Sergey ( Site 1906), St. Petersburg, Sankt-Peterburg
Sverdlovsk Regional Oncology Hospital ( Site 1909), Ekaterinburg, Sverdlovskaya Oblast
Republican Clinical Oncology Dispensary of Tatarstan MoH ( Site 1911), Kazan, Tatarstan, Respublika
Yaroslavl Regional SBIH Clinical Oncology Hospital ( Site 1910), Yaroslavl, Yaroslavskaya Oblast
Hospital Universitario Puerta de Hierro (Majadahonda) ( Site 1202), Majadahonda, Madrid
Hospital Universitario Quiron Madrid ( Site 1200), Pozuelo de Alarcon, Madrid
H.R.U Málaga - Hospital General ( Site 1206), Málaga, Malaga
H.U. Vall de Hebron ( Site 1201), Barcelona, Not set
Hospital Clinic de Barcelona ( Site 1204), Barcelona, Not set
Hospital Universitario Virgen Macarena ( Site 1205), Sevilla, Not set
Hospital Universitario La Fe ( Site 1203), Valencia, Not set
Chulalongkorn University ( Site 3003), Bangkok, Krung Thep Maha Nakhon
Ramathibodi Hospital. ( Site 3000), Bangkok, Krung Thep Maha Nakhon
Chiang Mai University Maharaj Nakorn Chiang Mai Hospital ( Site 3001), Chiang Mai, Not set
Srinagarind Hospital. Khon Kaen University ( Site 3002), Khon Kaen, Not set
Ankara Bilkent Sehir Hastanesi ( Site 2002), Ankara, Adana
Memorial Ankara Hastanesi ( Site 2006), Ankara, Not set
Istanbul Uni. Cerrahpasa Tip Fakultesi ( Site 2000), Istanbul, Not set
Medipol Universite Hastanesi ( Site 2003), Istanbul, Not set
Göztepe Prof. Dr. Süleyman Yalçın Şehir Hastanesi-oncology ( Site 2001), Istanbul, Not set
Ege University Medical Faculty ( Site 2005), Izmir, Not set
Medical center Medikal Plaza of Ecodnipro LLC ( Site 2107), Dnipro, Dnipropetrovska Oblast
SOGrigoriev Inst for Med Radiolgy and Oncology of NAMS of Ukraine-Clinical oncology and hematology (, Kharkiv, Kharkivska Oblast
Communal nonprofit enterprise "Kherson Regional Oncology Dispensary" of Kherson Regional Council (, Antonivka Village, Khersonska Oblast
LLC Ukrainian Center of Tomotherapy ( Site 2105), Kropyvnytskyi, Kirovohradska Oblast
Medical Center of Yuriy Spizhenko LLC.-Clinical Trial ( Site 2104), Kapitanivka Village, Kyivska Oblast
SNPE National Cancer Institute ( Site 2101), Kyiv, Kyivska Oblast
Medical Center Verum ( Site 2106), Kyiv, Kyivska Oblast
Kyiv City Clinical Oncology Center ( Site 2100), Kyiv, Not set
Weston Park Hospital ( Site 1406), Sheffield, Derbyshire
University College Hospital NHS Foundation Trust ( Site 1403), London-Camden, London, City Of
Guys and St Thomas NHS Foundation Trust ( Site 1410), London, London, City Of
Royal Marsden Hospital (Sutton) ( Site 1407), London, Surrey
Southampton General Hospital ( Site 1400), Southampton, Worcestershire
Leeds Teaching Hospitals NHS Trust ( Site 1401), Leeds, Not set
Christie NHS Foundation Trust ( Site 1409), Manchester, Not set
Conditions: Lung Neoplasms, Carcinoma, Non-Small-Cell Lung
Study of Chemotherapy With Pembrolizumab (MK-3475) Followed by Maintenance With Olaparib (MK-7339) for the First-Line Treatment of Women With BRCA Non-mutated Advanced Epithelial Ovarian Cancer (EOC) (MK-7339-001/KEYLYNK-001/ENGOT-ov43/GOG-3036)
Active Not Recruiting
The purpose of this study is to assess the efficacy and safety of treatment with carboplatin/paclitaxel\* PLUS pembrolizumab (MK-3475) and maintenance olaparib (MK-7339) in women with epithelial ovarian cancer (EOC), fallopian tube cancer, or primary peritoneal cancer.
The primary study hypotheses are that the combination of pembrolizumab plus carboplatin/paclitaxel\* followed by continued pembrolizumab and maintenance olaparib is superior to carboplatin/paclitaxel alone with respect to Progres... Read More
The purpose of this study is to assess the efficacy and safety of treatment with carboplatin/paclitaxel\* PLUS pembrolizumab (MK-3475) and maintenance olaparib (MK-7339) in women with epithelial ovarian cancer (EOC), fallopian tube cancer, or primary peritoneal cancer.
The primary study hypotheses are that the combination of pembrolizumab plus carboplatin/paclitaxel\* followed by continued pembrolizumab and maintenance olaparib is superior to carboplatin/paclitaxel alone with respect to Progression Free Survival (PFS) per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1) in participants with programmed death-ligand 1 (PD-L1)-positive tumors (Combined Positive Score \[CPS\]≥10) and in all participants, and that the combination of pembrolizumab plus carboplatin/paclitaxel followed by continued pembrolizumab is superior to carboplatin/paclitaxel alone with respect to PFS per RECIST 1.1 in participants with PD-L1-positive tumors (CPS≥10) and in all participants. Read Less
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
11/15/2024
Locations: University of Alabama at Birmingham (UAB) ( Site 0036), Birmingham, Alabama +226 locations
University of Alabama at Birmingham (UAB) ( Site 0036), Birmingham, Alabama
University of Arizona Cancer Center ( Site 0074), Tucson, Arizona
Disney Family Cancer Center ( Site 0042), Burbank, California
Kaiser Permanente Oncology Clinical Trial -Oakland ( Site 0077), Oakland, California
Kaiser Permanente Oncology Clinical Trials-Roseville ( Site 0084), Roseville, California
Kaiser Permanente Oncology Clinical Trials-Sacramento ( Site 0083), Sacramento, California
Kaiser Permanente Oncology Clinical Trial - San Francisco ( Site 0078), San Francisco, California
Kaiser Permanente Oncology Clinical Trial - Santa Clara ( Site 0079), Santa Clara, California
Kaiser Permanente N. CA Regional Oncology Clinical Trials ( Site 0008), Vallejo, California
Kaiser Permanente Oncology Clinical Trial - Walnut Creek ( Site 0080), Walnut Creek, California
Smilow Cancer Center at Yale-New Haven ( Site 0057), New Haven, Connecticut
Sarasota Memorial Hospital ( Site 0023), Sarasota, Florida
Emory School of Medicine ( Site 0053), Atlanta, Georgia
Northeast Georgia Medical Center ( Site 0029), Gainesville, Georgia
Memorial Health University Medical Center ( Site 0011), Savannah, Georgia
Rush University Medical Center ( Site 0019), Chicago, Illinois
University of Chicago ( Site 0049), Chicago, Illinois
Dr. Sudarshan K. Sharma, LTD ( Site 0061), Hinsdale, Illinois
Saint Vincent Hospital and Health Center ( Site 0012), Indianapolis, Indiana
University of Iowa Hospital and Clinics ( Site 0005), Iowa City, Iowa
University of Kentucky ( Site 0045), Lexington, Kentucky
Weinberg Cancer Institute at Franklin Square ( Site 0035), Baltimore, Maryland
Saint Dominic - Jackson Memorial Hospital ( Site 0072), Jackson, Mississippi
Washington University - School of Medicine ( Site 0062), Saint Louis, Missouri
Nebraska Methodist Hospital ( Site 0063), Omaha, Nebraska
Dartmouth Hitchcock Medical Center ( Site 0024), Lebanon, New Hampshire
MD Anderson Cancer Center at Cooper ( Site 0067), Camden, New Jersey
Holy Name Medical Center ( Site 0037), Teaneck, New Jersey
Northwell Health- Monter Cancer Center ( Site 0075), Lake Success, New York
Sanford Roger Maris Cancer Center ( Site 0082), Fargo, North Dakota
Miami Valley Hospital [Dayton, OH] ( Site 0073), Centerville, Ohio
Oncology/Hematology Care Clinical Trials, LLC ( Site 8001), Cincinnati, Ohio
The Bing Cancer Center ( Site 0044), Columbus, Ohio
OSU Wexner Medical Center ( Site 0076), Hilliard, Ohio
Women and Infants Hospital [Providence, RI] ( Site 0039), Providence, Rhode Island
Sanford Gynecology Oncology ( Site 0004), Sioux Falls, South Dakota
Texas Oncology, P.A. - Bedford ( Site 8005), Bedford, Texas
Texas Oncology-Dallas Presbyterian Hospital ( Site 8004), Dallas, Texas
Parkland Hospital ( Site 0081), Dallas, Texas
UT Southwestern Medical Center ( Site 0046), Dallas, Texas
Texas Oncology, P.A. Texas Oncology-Tyler ( Site 8006), Tyler, Texas
Virginia Cancer Specialists, PC ( Site 8003), Gainesville, Virginia
MEDICAL COLLEGE OF WISCONSIN ( Site 0064), Milwaukee, Wisconsin
St George Hospital ( Site 2207), Kogarah, New South Wales
Cairns and Hinterland Hospital and Health Service ( Site 2201), Cairns, Queensland
Ballarat Health Services ( Site 2202), Ballarat, Victoria
Monash Health ( Site 2204), Clayton, Victoria
Sunshine Hospital. ( Site 2205), St Albans, Victoria
Imelda Ziekenhuis Bonheiden ( Site 0301), Bonheiden, Antwerpen
UZ Leuven Campus Gasthuisberg ( Site 0306), Leuven, Antwerpen
Cliniques Universitaires Saint-Luc ( Site 0312), Brussels, Bruxelles-Capitale, Region De
Grand Hopital de Charleroi ( Site 0302), Charleroi, Hainaut
CHU de Liege ( Site 0310), Liège, Liege
Jessa Ziekenhuis ( Site 0309), Hasselt, Limburg
Centre Hospitalier de l'Ardenne ( Site 0303), Libramont, Luxembourg
AZ Maria Middelares Gent ( Site 0300), Gent, Oost-Vlaanderen
UZ Gent ( Site 0307), Gent, Oost-Vlaanderen
Instituto do Cancer do Ceara ( Site 2707), Fortaleza, Ceara
Hospital Araujo Jorge Associacao de Combate ao Cancer de Goias ( Site 2708), Goiania, Goias
Hospital Erasto Gaertner ( Site 2716), Curitiba, Parana
Hospital de Caridade de Ijui ( Site 2712), Ijui, Rio Grande Do Sul
Hospital Bruno Born ( Site 2704), Lajeado, Rio Grande Do Sul
Hospital Nossa Senhora Da Conceicao ( Site 2703), Porto Alegre, Rio Grande Do Sul
Instituto Nacional de Cancer Hospital do Cancer II ( Site 2700), Rio de Janeiro, Not set
Instituto do Cancer do Estado de Sao Paulo - ICESP ( Site 2714), Sao Paulo, Not set
Clinica de Pesquisas e Ctro de Estudos Onc. Ginecol. e Mamaria Ltda ( Site 2706), Sao Paulo, Not set
Real e Benemerita Associacao Portuguesa de Beneficencia ( Site 2710), Sao Paulo, Not set
Tom Baker Cancer Centre ( Site 0200), Calgary, Alberta
Kingston Health Sciences Centre ( Site 0207), Kingston, Ontario
The Credit Valley Hospital ( Site 0206), Mississauga, Ontario
Princess Margaret Hospital.. ( Site 0202), Toronto, Ontario
CIUSSS du Saguenay-Lac-St-Jean ( Site 0218), Chicoutimi, Quebec
CIUSSS de l Est de L Ile de Montreal - Hopital Maisonneuve-Rosemont ( Site 0219), Montreal, Quebec
Centre Hospitalier de l Universite de Montreal - CHUM ( Site 0208), Montreal, Quebec
Royal Victoria Hospital McGill University Health Centre ( Site 0211), Montreal, Quebec
Centro Investigación del Cáncer James Lind ( Site 2810), Temuco, Araucania
Centro de Investigacion y desarrollo Oncologico SpA - CIDO SpA ( Site 2808), Temuco, Araucania
Fundacion Arturo Lopez Perez FALP ( Site 2800), Santiago, Region M. De Santiago
Sociedad Oncovida S.A. ( Site 2807), Santiago, Region M. De Santiago
Iram Cancer Research ( Site 2809), Santiago, Region M. De Santiago
Pontificia Universidad Catolica de Chile ( Site 2805), Santiago, Region M. De Santiago
Oncocentro ( Site 2801), Vina del Mar, Valparaiso
Centro Oncologico Antofagasta ( Site 2804), Antofagasta, Not set
Biomelab S A S ( Site 2900), Barranquilla, Atlantico
Sociedad de Oncología Y Hematología del Cesar S.A.S. ( Site 2913), Valledupar, Cesar
Oncomedica S.A. ( Site 2911), Monteria, Cordoba
Instituto Nacional de Cancerologia E.S.E ( Site 2910), Bogota, Distrito Capital De Bogota
Clinica Colsanitas S.A. Sede Clinica Universitaria Colombia ( Site 2912), Bogota, Distrito Capital De Bogota
Centro Medico Imbanaco de Cali S.A ( Site 2909), Cali, Valle Del Cauca
Hemato Oncologos S.A. ( Site 2906), Cali, Valle Del Cauca
Fakultni nemocnice Brno ( Site 0404), Brno, Brno-mesto
Fakultni nemocnice Ostrava ( Site 0403), Ostrava-Poruba, Moravskoslezsky Kraj
Vseobecna fakultni nemocnice v Praze ( Site 0400), Praha, Praha, Hlavni Mesto
Nemocnice Na Bulovce ( Site 0401), Praha, Praha, Hlavni Mesto
Fakultni nemocnice Olomouc ( Site 0402), Olomouc, Not set
Hopital Prive Jean Mermoz ( Site 0607), Lyon, Auvergne
Centre Paul Strauss ( Site 0615), Strasbourg, Bas-Rhin
Hopital de la Timone ( Site 0617), Marseille, Bouches-du-Rhone
CHU de Brest -Site Hopital Morvan ( Site 0616), Brest, Bretagne
Institut de Cancerologie du Gard - CHU Caremeau ( Site 0610), Nimes, Gard
Institut de Cancerologie Lucien Neuwirth ( Site 0613), Saint-Priest-en-Jarez, Loire
Centre D Oncologie de Gentilly ( Site 0609), Nancy, Meurthe-et-Moselle
Institut Gustave Roussy ( Site 0600), Villejuif, Val-de-Marne
Hopital Tenon ( Site 0612), Paris, Not set
Marienhospital Stuttgart Vincenz von Paul Kliniken gGmbH ( Site 0707), Stuttgart, Baden-Wurttemberg
Klinikum Rechts der Isar. Technischen Universitaet Muenchen ( Site 0710), Muenchen, Bayern
Uniklinik RWTH Aachen ( Site 0718), Aachen, Nordrhein-Westfalen
Gynaekologisches Zentrum ( Site 0712), Bonn, Nordrhein-Westfalen
Klinikum Dortmund gGmbH ( Site 0717), Dortmund, Nordrhein-Westfalen
Universitaetsklinikum Duesseldorf ( Site 0704), Duesseldorf, Nordrhein-Westfalen
HELIOS Klinikum Krefeld ( Site 0715), Krefeld, Nordrhein-Westfalen
Universitaetsklinikum Muenster ( Site 0720), Muenster, Nordrhein-Westfalen
Caritas Klinikum Saarbruecken St. Theresia ( Site 0702), Saarbruecken, Saarland
Klinikum Chemnitz gGmbH ( Site 0711), Chemnitz, Sachsen
Staedtisches Krankenhaus Kiel GmbH ( Site 0709), Kiel, Schleswig-Holstein
Charite Campus Virchow-Klinikum - CVK ( Site 0700), Berlin, Not set
Pecsi Tudomanyegyetem Klinikai Kozpont ( Site 0805), Pecs, Baranya
Borsod-Abauj-Zemplen Megyei Korhaz es Egyetemi Oktato Korhaz ( Site 0802), Miskolc, Borsod-Abauj-Zemplen
Orszagos Onkologiai Intezet ( Site 0800), Budapest, Not set
Uzsoki Utcai Korhaz ( Site 0803), Budapest, Not set
Debreceni Egyetem Klinikai Kozpont ( Site 0801), Debrecen, Not set
Soroka Medical Center ( Site 1006), Beer-Sheva, Not set
Hillel Yaffe Medical Center ( Site 1011), Hadera, Not set
Carmel Medical Center ( Site 1007), Haifa, Not set
Rambam Medical Center ( Site 1002), Haifa, Not set
Edith Wolfson Medical Center ( Site 1003), Holon, Not set
Shaare Zedek Medical Center ( Site 1005), Jerusalem, Not set
Rabin Medical Center ( Site 1004), Petah Tikva, Not set
Chaim Sheba Medical Center ( Site 1000), Ramat Gan, Not set
Sourasky Medical Center ( Site 1001), Tel Aviv, Not set
IRCCS Giovanni Paolo II. Ospedale Oncologico ( Site 1108), Bari, Abruzzo
Istituto Europeo di Oncologia ( Site 1100), Milano, Lombardia
A.O.U. Citta della Salute e della Scienza di Torino ( Site 1104), Torino, Piemonte
Istituto Oncologico Veneto IRCCS ( Site 1113), Padova, Veneto
Sacro Cuore di Gesu Fatebenefratelli ( Site 1112), Benevento, Not set
Ospedale Cannizzaro ( Site 1110), Catania, Not set
ASST Lecco. Ospedale A. Manzoni ( Site 1101), Lecco, Not set
Fondazione IRCCS Istituto Nazionale dei Tumori di Milano ( Site 1115), Milano, Not set
A.O.U. Federico II di Napoli ( Site 1107), Napoli, Not set
Azienda Ospedaliera Policlinico Umberto I ( Site 1111), Roma, Not set
Policlinico Universitario Gemelli ( Site 1105), Roma, Not set
Presidio Ospedaliero Santa Chiara ( Site 1109), Trento, Not set
A.O. Univ. S. M. della Misericordia ( Site 1114), Udine, Not set
National Cancer Center Hospital East ( Site 2602), Kashiwa, Chiba
National Hospital Organization Shikoku Cancer Center ( Site 2601), Matsuyama, Ehime
Ehime University Hospital ( Site 2600), Toon, Ehime
Gunma Prefectural Cancer Center ( Site 2609), Ota, Gunma
Hokkaido University Hospital ( Site 2607), Sapporo, Hokkaido
Iwate Medical University Hospital ( Site 2606), Shiwa-gun, Iwate
St. Marianna University School of Medicine Hospital ( Site 2613), Kawasaki, Kanagawa
University of the Ryukyus Hospital ( Site 2616), Nakagami-gun, Okinawa
Saitama Medical University International Medical Center ( Site 2604), Hidaka, Saitama
Saitama Cancer Center ( Site 2614), Kitaadachi-gun, Saitama
National Defense Medical College Hospital ( Site 2608), Tokorozawa, Saitama
Kyorin University Hospital ( Site 2610), Mitaka, Tokyo
Kagoshima City Hospital ( Site 2612), Kagoshima, Not set
Niigata Cancer Center Hospital ( Site 2618), Niigata, Not set
Osaka International Cancer Institute ( Site 2617), Osaka, Not set
National Cancer Center Hospital ( Site 2605), Tokyo, Not set
Seoul National University Bundang Hospital ( Site 2404), Seongnam-si, Kyonggi-do
Seoul National University Hospital ( Site 2403), Seoul, Not set
Severance Hospital Yonsei University Health System ( Site 2400), Seoul, Not set
Asan Medical Center ( Site 2402), Seoul, Not set
Samsung Medical Center ( Site 2401), Seoul, Not set
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie (, Warszawa, Mazowieckie
Bialostockie Centrum Onkologii ( Site 1412), Bialystok, Podlaskie
Szpitale Pomorskie Sp. z o.o. ( Site 1407), Gdynia, Pomorskie
Narodowy Instytut Onkologii - Oddzial w Gliwicach ( Site 1406), Gliwice, Slaskie
Swietokrzyskie Centrum Onkologii SPZOZ ( Site 1410), Kielce, Swietokrzyskie
Szpital Kliniczny im. Przemienienia Panskiego Uniwersytetu Medycznego im. K. Marcinkowskiego w Pozna, Poznan, Wielkopolskie
Arkhangelsk Clinical Oncological Dispensary ( Site 1508), Arkhangelsk, Arkhangel Skaya Oblast
Republican Clinical Oncology Dispensary of Republic of Bashkortostan ( Site 1507), Ufa, Baskortostan, Respublika
A. Tsyb Medical Radiological Research Center ( Site 1513), Obninsk, Kaluzskaja Oblast
FSBI National Medical Oncology Research Center n.a. N.N. Blokhina ( Site 1500), Moscow, Moskva
FSCC of Special Types of Med. Care and Technologies ( Site 1503), Moscow, Moskva
Medical Rehabilitation Center ( Site 1502), Moscow, Moskva
City Clinical Oncology Center ( Site 1505), Saint Petersburg, Sankt-Peterburg
National Medical Research Center of Oncology N.A. N.N. Petrov ( Site 1504), Saint-Petersburg, Sankt-Peterburg
Republican Clinical Oncology Dispensary of Tatarstan MoH ( Site 1509), Kazan, Tatarstan, Respublika
Cancer Care Langenhoven Drive Oncology Centre ( Site 1701), Port Elizabeth, Eastern Cape
Groote Schuur Hospital ( Site 1704), Cape Town, Gauteng
Wits Clinical Research ( Site 1702), Johannesburg, Gauteng
Department of Medical Oncology ( Site 1703), Pretoria, Gauteng
Curo Oncology ( Site 1710), Pretoria, Gauteng
Wilgers Oncology Centre ( Site 1705), Pretoria, Gauteng
Little Company of Mary Hospital ( Site 1700), Pretoria, Gauteng
Sandton Oncology Medical Group PTY LTD ( Site 1712), Sandton, Gauteng
The Oncology Centre ( Site 1709), Durban, Kwazulu-Natal
Cancercare ( Site 1706), Cape Town, Western Cape
Outeniqua Cancercare Oncology Unit ( Site 1708), George, Western Cape
Cape Town Oncology Trials Pty Ltd ( Site 1707), Kraaifontein, Western Cape
Instituto Catalan de Oncologia ICO - Hospital Duran i Reynals ( Site 1603), Hospitalet de Llobregat, Barcelona
Xarxa Assistencial Universitaria Manresa ( Site 1605), Manresa, Barcelona
Hospital de Terrassa ( Site 1606), Terrassa, Barcelona
Hospital Universitario de Donostia ( Site 1602), Donostia, Gipuzkoa
Complejo Hospitalario Universitario A Coruna. CHUAC ( Site 1608), A Coruna, La Coruna
Instituto Valenciano de Oncologia ( Site 1601), Valencia, Valenciana, Comunitat
Hospital General Universitario de Valencia ( Site 1610), Valencia, Valenciana, Comunitat
Hospital Provincial San Pedro de Alcantara ( Site 1607), Caceres, Not set
Hospital Universitario Lucus Augusti ( Site 1609), Lugo, Not set
Clinica Universitaria de Navarra ( Site 1600), Madrid, Not set
Hospital Universitario Virgen del Rocio ( Site 1604), Sevilla, Not set
Changhua Christian Hospital ( Site 2507), Changhua, Not set
China Medical University Hospital ( Site 2506), Taichung, Not set
Taichung Veterans General Hospital ( Site 2510), Taichung, Not set
National Cheng Kung University Hospital ( Site 2508), Tainan, Not set
National Taiwan University Hospital ( Site 2502), Taipei, Not set
MacKay Memorial Hospital ( Site 2500), Taipei, Not set
Taipei Veterans General Hospital ( Site 2503), Taipei, Not set
Linkou Chang Gung Memorial Hospital ( Site 2501), Taoyuan, Not set
Istanbul Acibadem University Atakent Hospital ( Site 1902), Kucukcekmece, Istanbul
Etlik Zubeyde Hanim Kadin Hastaliklari Egitim ve Arastirma Hastanesi ( Site 1903), Ankara, Not set
Ankara UTF Cebeci Arastırma ve Uygulama Hastanesi ( Site 1905), Ankara, Not set
Akdeniz Universitesi Tıp Fakultesi ( Site 1901), Antalya, Not set
Uludag Universitesi Tip Fakultesi ( Site 1904), Bursa, Not set
Istanbul Universitesi Istanbul Tip Fakultesi ( Site 1900), Istanbul, Not set
Bakirkoy Sadi Konuk Egitim ve Arastirma Hastanesi ( Site 1907), Istanbul, Not set
Medipol Universite Hastanesi ( Site 1909), Istanbul, Not set
Sakarya Universitesi Tip Fakultesi Hastanesi ( Site 1906), Sakarya, Not set
MI Precarpathian Clinical Oncology Center ( Site 2181), Ivano-Frankivsk, Ivano-Frankivska Oblast
Grigoriev Institute for medical Radiology NAMS of Ukraine ( Site 2180), Kharkiv, Kharkivska Oblast
Municipal non-profit Enterprise Khmelnytskyi Regional Antitu-Gynecological Oncology department, Poli, Khmelnytskyi, Khmelnytska Oblast
Lviv State Oncology Regional Treatment and Diagnostic Center ( Site 2170), Lviv, Lvivska Oblast
MI Odessa Regional Oncological Centre ( Site 2121), Odesa, Odeska Oblast
RMI - Sumy Regional Clinical Oncology Dispensary ( Site 2191), Sumy, Sumska Oblast
Central City Clinical Hospital ( Site 2150), Uzhgorod, Zakarpatska Oblast
Kyiv City Clinical Oncological Center ( Site 2140), Kyiv, Not set
Study of Olaparib Plus Pembrolizumab Versus Chemotherapy Plus Pembrolizumab After Induction With First-Line Chemotherapy Plus Pembrolizumab in Triple Negative Breast Cancer (TNBC) (MK-7339-009/KEYLYNK-009)
Active Not Recruiting
The purpose of this study is to compare the efficacy of olaparib (MK-7339) plus pembrolizumab (MK-3475) with chemotherapy plus pembrolizumab after induction with first-line chemotherapy plus pembrolizumab in triple negative breast cancer (TNBC). The primary hypotheses are:
1. Olaparib plus pembrolizumab is superior to chemotherapy plus pembrolizumab with respect to progression-free survival (PFS).
2. Olaparib plus pembrolizumab is superior to chemotherapy plus pembrolizumab with respect to over... Read More
The purpose of this study is to compare the efficacy of olaparib (MK-7339) plus pembrolizumab (MK-3475) with chemotherapy plus pembrolizumab after induction with first-line chemotherapy plus pembrolizumab in triple negative breast cancer (TNBC). The primary hypotheses are:
1. Olaparib plus pembrolizumab is superior to chemotherapy plus pembrolizumab with respect to progression-free survival (PFS).
2. Olaparib plus pembrolizumab is superior to chemotherapy plus pembrolizumab with respect to overall survival (OS).
As of Amendment 3, study enrollment was discontinued. Participants who were receiving benefit from the study intervention could continue treatment until criteria for discontinuation are met. Participants who are on study treatment or in follow-up phase will no longer have tumor response assessments by BICR. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/11/2024
Locations: Pacific Cancer Care ( Site 0142), Monterey, California +121 locations
Pacific Cancer Care ( Site 0142), Monterey, California
UCSF Helen Diller Family Comprehensive Cancer Center ( Site 0138), San Francisco, California
John Wayne Cancer Institute ( Site 0111), Santa Monica, California
St. Joseph Heritage Healthcare ( Site 0104), Santa Rosa, California
University of Miami Sylvester CC ( Site 0146), Miami, Florida
Georgia Cancer Center at Augusta University ( Site 0129), Augusta, Georgia
University of Chicago ( Site 0159), Chicago, Illinois
Massachusetts General Hospital ( Site 0155), Boston, Massachusetts
Henry Ford Health System ( Site 0103), Detroit, Michigan
Virginia Piper Cancer Institute ( Site 0157), Minneapolis, Minnesota
Memorial Sloan Kettering Cancer Center- Monmouth ( Site 0161), Middletown, New Jersey
MSKCC-Bergen ( Site 0162), Montvale, New Jersey
Memorial Sloan-Kettering Cancer Center at Commack ( Site 0160), Commack, New York
Memorial Sloan-Kettering Cancer Center ( Site 0156), New York, New York
Mercy Clinic Oncology and Hematology ( Site 0110), Oklahoma City, Oklahoma
The Center For Cancer And Blood Disorders ( Site 0151), Fort Worth, Texas
Texas Oncology-New Braunfels ( Site 0168), New Braunfels, Texas
Texas Oncology-San Antonio Northeast ( Site 0165), San Antonio, Texas
Texas Oncology-San Antonio Medical Center ( Site 0158), San Antonio, Texas
Texas Oncology - San Antonio Stone Oak ( Site 0166), San Antonio, Texas
Renovatio Clinical ( Site 0117), The Woodlands, Texas
Virginia Oncology Associates ( Site 0163), Newport News, Virginia
Virginia Oncology Associates ( Site 0153), Norfolk, Virginia
Virginia Oncology Associates ( Site 0164), Virginia Beach, Virginia
YVMH dba Virginia Mason Memorial/North Star Lodge Cancer Center ( Site 0128), Yakima, Washington
Princess Margaret Cancer Centre ( Site 0005), Toronto, Ontario
CSSS de Laval- Hopital de la Cite de la Sante ( Site 0011), Laval, Quebec
Centre Hospitalier de l Universite de Montreal - CHUM ( Site 0003), Montreal, Quebec
Jewish General Hospital ( Site 0010), Montreal, Quebec
McGill University Health Centre ( Site 0002), Montreal, Quebec
Centro Investigación del Cáncer James Lind ( Site 0510), Temuco, Araucania
IC La Serena Research ( Site 0511), La Serena, Coquimbo
Fundacion Arturo Lopez Perez ( Site 0500), Santiago, Region M. De Santiago
Pontificia Universidad Catolica de Chile ( Site 0501), Santiago, Region M. De Santiago
Oncocentro ( Site 0502), Vina del Mar, Valparaiso
Fundacion Colombiana de Cancerologia Clinica Vida ( Site 0601), Medellin, Antioquia
Clinica de la Costa Ltda. ( Site 0600), Barranquilla, Atlantico
Organizacion Clinica Bonnadona-Prevenir S.A.S. ( Site 0609), Barranquilla, Atlantico
Oncomedica S.A. ( Site 0606), Monteria, Cordoba
Fundacion Valle del Lili ( Site 0602), Cali, Valle Del Cauca
Hemato Oncologos S.A. ( Site 0603), Cali, Valle Del Cauca
Centre Francois Baclesse ( Site 1012), Caen, Calvados
CHU-Jean Minjoz ( Site 1013), Besancon, Doubs
Institut Claudius Regaud IUCT Oncopole ( Site 1001), Toulouse, Haute-Garonne
Centre de Cancerologie du Grand Montpellier ( Site 1009), Montpellier, Languedoc-Roussillon
CHR-METZ-THIONVILLE - Hopital de Mercy ( Site 1007), Metz, Moselle
Centre Jean Perrin ( Site 1003), Clermont-Ferrand Cedex 01, Puy-de-Dome
Centre Leon Berard ( Site 1018), Lyon, Rhone
Centre Henri Becquerel ( Site 1020), Rouen, Seine-Maritime
CHU Amiens Hopital Sud ( Site 1023), Amiens, Somme
Institut Gustave Roussy ( Site 1010), Villejuif, Val-de-Marne
Institut Sainte Catherine ( Site 1026), Avignon, Vaucluse
Hôpital Saint-Louis ( Site 1025), Paris, Not set
Universitaetsklinikum Mannheim GmbH ( Site 1213), Mannheim, Baden-Wurttemberg
Universitaetsklinikum Erlangen ( Site 1201), Erlangen, Bayern
Klinik und Poliklinik fuer Frauenheilkunde und Geburtshilfe ( Site 1200), Muenchen, Bayern
Hochwaldkrankenhaus Bad Nauheim ( Site 1211), Bad Nauheim, Hessen
Sana Klinikum Offenbach Klinik fuer Gynakologie und Geburtshilfe ( Site 1206), Offenbach am Main, Hessen
Gynaekologisch-onkologische Praxis Hannover ( Site 1207), Hannover, Niedersachsen
Gynaekologisches Zentrum-Schwerpunkt Gyn. Onkologie ( Site 1205), Bonn, Nordrhein-Westfalen
Universitaetsklinikum AoeR Duesseldorf ( Site 1210), Duesseldorf, Nordrhein-Westfalen
Kliniken Essen-Mitte ( Site 1215), Essen, Nordrhein-Westfalen
Frauenklinik St. Louise ( Site 1216), Paderborn, Nordrhein-Westfalen
Universitaetsklinikum Carl Gustav Carus ( Site 1203), Dresden, Sachsen
Bacs-Kiskun Megyei Korhaz-Onkoradiologiai Kozpont ( Site 1608), Kecskemét, Bacs-Kiskun
Pecsi Tudomanyegyetem Klinikai Kozpont ( Site 1607), Pecs, Baranya
Jasz Nagykun Szolnok Megyei Hetenyi Geza Korhaz Rendelointezet ( Site 1601), Szolnok, Jasz-Nagykun-Szolnok
Zala Megyei Szent Rafael Korhaz ( Site 1605), Zalaegerszeg, Zala
Orszagos Onkologiai Intezet ( Site 1602), Budapest, Not set
Debreceni Egyetem Klinikai Kozpont ( Site 1600), Debrecen, Not set
Somogy Megyei Kaposi Mor Oktato Korhaz ( Site 1604), Kaposvar, Not set
Cork University Hospital ( Site 0902), Cork, Not set
St Vincents University Hospital ( Site 0900), Dublin, Not set
Aichi Cancer Center Hospital ( Site 2202), Nagoya, Aichi
Hyogo College of Medicine Hospital ( Site 2203), Nishinomiya, Hyogo
Fukushima Medical University Hospital ( Site 2201), Fukushima, Not set
Hiroshima City Hiroshima Citizens Hospital ( Site 2204), Hiroshima, Not set
National Hospital Organization - Osaka National Hospital - Institute For Clinical Research (Site 2200), Osaka, Not set
National Cancer Center ( Site 2406), Goyang-si, Kyonggi-do
Seoul National University Bundang Hospital ( Site 2409), Seongnam-si, Kyonggi-do
Ajou University Hospital ( Site 2407), Suwon-si, Kyonggi-do
Kyungpook National University Chilgok Hospital ( Site 2402), Daegu, Taegu-Kwangyokshi
Gachon University Gil Medical Center ( Site 2408), Incheon, Not set
Seoul National University Hospital ( Site 2403), Seoul, Not set
Severance Hospital Yonsei University Health System ( Site 2401), Seoul, Not set
Asan Medical Center ( Site 2404), Seoul, Not set
Samsung Medical Center ( Site 2405), Seoul, Not set
Regionalny Szpital Specjalistyczny Latawiec ( Site 1917), Swidnica, Dolnoslaskie
Pratia MCM Krakow ( Site 1919), Krakow, Malopolskie
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie (Site 1908), Warszawa, Mazowieckie
Szpital Morski im. PCK. Szpitale Pomorskie Sp. Z o.o ( Site 1913), Gdynia, Pomorskie
Narodowy Instytut Onkologii - Oddzial w Gliwicach ( Site 1912), Gliwice, Slaskie
Pleszewskie Centrum Medyczne w Pleszewie Sp. z o.o. ( Site 1909), Pleszew, Wielkopolskie
Hospital Universitario Reina Sofia ( Site 0705), Cordoba, Andalucia
Hospital General Arnau de Vilanova de Valencia ( Site 0706), Valencia, Valenciana, Comunitat
Instituto Oncologico Baselga.Hospital Quiron. ( Site 0707), Barcelona, Not set
Hospital Universitari Vall d Hebron ( Site 0701), Barcelona, Not set
Hospital Clinic I Provincial de Barcelona ( Site 0702), Barcelona, Not set
Clinica Universitaria Navarra - Madrid ( Site 0700), Madrid, Not set
Kaohsiung Chang Gung Memorial Hospital ( Site 2304), Kaohsiung, Not set
National Cheng Kung University Hospital ( Site 2303), Tainan, Not set
MacKay Memorial Hospital ( Site 2301), Taipei, Not set
Koo Foundation Sun Yat-Sen Cancer Center ( Site 2300), Taipei, Not set
China Medical University Hospital ( Site 2302), Taipei, Not set
Chernihiv Medical Center of Modern Oncology ( Site 1520), Chernihiv, Chernihivska Oblast
Dnipropetrovsk City Multidiscipline Clinical Hosp. 4 of DRC ( Site 1502), Dnipro, Dnipropetrovska Oblast
CI Krivorizhskiy oncology dispensery ( Site 1504), Kryviy Rih, Dnipropetrovska Oblast
MI Precarpathian Clinical Oncology Center ( Site 1506), Ivano-Frankivsk, Ivano-Frankivska Oblast
Grigoriev Institute for medical Radiology NAMS of Ukraine ( Site 1508), Kharkiv, Kharkivska Oblast
Communal non profit enterprise Regional Clinical Oncology Center ( Site 1512), Kharkiv, Kharkivska Oblast
SI-Zaytsev institute of general and urgent surgery-NAMS ( Site 1518), Kharkiv, Kharkivska Oblast
Medical Centre Consilium Medical ( Site 1514), Kyiv, Kyivska Oblast
Medical center of the Limited Liability Company Yulis ( Site 1517), Zaporizhzhia, Zaporizka Oblast
Medical Centre LLC Oncolife ( Site 1510), Zaporizhzhya, Zaporizka Oblast
Zhytomyr Regional Oncology Center ( Site 1515), Zhytomyr, Zhytomyrska Oblast
Medical Center Verum ( Site 1501), Kyiv, Not set
Raigmore Hospital ( Site 0915), Inverness, Highland
Blackpool Victoria Hospital ( Site 0921), Blackpool, Lancashire
North West Cancer Centre ( Site 0922), Londonderry, London, City Of
Barts Health NHS Trust ( Site 0912), London, London, City Of
Musgrove Park Hospital ( Site 0918), Taunton, Somerset
The Christie NHS Foundation Trust ( Site 0914), Manchester, Not set
Conditions: Triple Negative Breast Neoplasms
Dose Escalation and Expansion Study of GSK3359609 in Participants With Selected Advanced Solid Tumors (INDUCE-1)
Completed
GSK3359609 is an anti-Inducible T cell Co-Stimulator (ICOS) receptor agonist antibody intended for the treatment of cancers of different histology. This is a first-time-in-human (FTIH), open-label, multicenter study designed to investigate the safety, pharmacology, and preliminary antitumor activity in participants with selected, advanced or recurrent solid tumors with the aim to establish recommended dose(s) of GSK3359609 for further exploration as monotherapy and in combination with pembrolizu... Read More
GSK3359609 is an anti-Inducible T cell Co-Stimulator (ICOS) receptor agonist antibody intended for the treatment of cancers of different histology. This is a first-time-in-human (FTIH), open-label, multicenter study designed to investigate the safety, pharmacology, and preliminary antitumor activity in participants with selected, advanced or recurrent solid tumors with the aim to establish recommended dose(s) of GSK3359609 for further exploration as monotherapy and in combination with pembrolizumab or chemotherapy regimens. The study is comprised of two primary parts, each composed of two phases: Part 1: GSK3359609 monotherapy with Part 1A as dose escalation phase and Part 1B as cohort expansion phase; Part 2: GSK3359609 combination therapy with Part 2A pembrolizumab or GSK3174998 or chemotherapy or pembrolizumab plus chemotherapy or dostarlimab plus cobolimab or Bintrafusp alfa combination dose escalation phase and Part 2B expansion phase with pembrolizumab. The primary objective of the study is to determine the safety, tolerability, maximum tolerated dose or the maximum administered dose of GSK3359609 alone or in combination. Read Less
Gender:
ALL
Ages:
Between 18 years and 93 years
Trial Updated:
11/08/2024
Locations: GSK Investigational Site, Duarte, California +27 locations
GSK Investigational Site, Duarte, California
GSK Investigational Site, Los Angeles, California
GSK Investigational Site, Sarasota, Florida
GSK Investigational Site, New York, New York
GSK Investigational Site, New York, New York
GSK Investigational Site, Oklahoma City, Oklahoma
GSK Investigational Site, Philadelphia, Pennsylvania
GSK Investigational Site, Nashville, Tennessee
GSK Investigational Site, Nashville, Tennessee
GSK Investigational Site, Heidelberg, Victoria
GSK Investigational Site, Melbourne, Victoria
GSK Investigational Site, Nedlands, Western Australia
GSK Investigational Site, Toronto, Ontario
GSK Investigational Site, Shnghai, Not set
GSK Investigational Site, Bordeaux Cedex, Not set
GSK Investigational Site, Lyon cedex 08, Not set
GSK Investigational Site, Paris, Not set
GSK Investigational Site, Villejuif cedex, Not set
GSK Investigational Site, Siena, Toscana
GSK Investigational Site, Chiba, Not set
GSK Investigational Site, Osaka, Not set
GSK Investigational Site, Tokyo, Not set
GSK Investigational Site, Amsterdam, Not set
GSK Investigational Site, Barcelona, Not set
GSK Investigational Site, Barcelona, Not set
GSK Investigational Site, Madrid, Not set
GSK Investigational Site, Mága, Not set
GSK Investigational Site, Sevilla, Not set
Conditions: Neoplasms
Chemotherapy and Pelvic Radiation Therapy With or Without Additional Chemotherapy in Treating Patients With High-Risk Early-Stage Cervical Cancer After Radical Hysterectomy
Active Not Recruiting
RATIONALE: Drugs used in chemotherapy, such as cisplatin, paclitaxel, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. It is not yet known whether chemotherapy and radiation therapy are more effective when given with or without additional chemotherapy in treating cervical cancer.
PURPOSE: This randomized phase III trial is studying chemotherapy... Read More
RATIONALE: Drugs used in chemotherapy, such as cisplatin, paclitaxel, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. It is not yet known whether chemotherapy and radiation therapy are more effective when given with or without additional chemotherapy in treating cervical cancer.
PURPOSE: This randomized phase III trial is studying chemotherapy and pelvic radiation therapy to see how well they work when given with or without additional chemotherapy in treating patients with high-risk early-stage cervical cancer after radical hysterectomy. Read Less
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
11/07/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama +124 locations
University of Alabama at Birmingham, Birmingham, Alabama
Providence Hospital, Mobile, Alabama
Providence Alaska Medical Center, Anchorage, Alaska
Arizona Center for Cancer Care-Peoria, Peoria, Arizona
Saint Joseph's Hospital and Medical Center, Phoenix, Arizona
Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank, California
Mercy San Juan Medical Center, Carmichael, California
City of Hope Medical Center, Duarte, California
Saint Joseph Hospital - Orange, Orange, California
Pomona Valley Hospital Medical Center, Pomona, California
Mercy Cancer Center, Sacramento, California
Mercy General Hospital Radiation Oncology Center, Sacramento, California
Saint Helena Hospital, Saint Helena, California
University of California At San Diego, San Diego, California
Penrose-Saint Francis Healthcare, Colorado Springs, Colorado
Hartford Hospital, Hartford, Connecticut
The Hospital of Central Connecticut, New Britain, Connecticut
University of Miami Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach, Florida
Memorial Healthcare System - Joe DiMaggio Children's Hospital, Hollywood, Florida
Jackson Memorial Hospital-Holtz Children's Hospital, Miami, Florida
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida
Baptist Hospital of Miami, Miami, Florida
Florida Hospital, Orlando, Florida
Grady Health System, Atlanta, Georgia
Northside Hospital, Atlanta, Georgia
Northeast Georgia Medical Center, Gainesville, Georgia
Memorial Health University Medical Center, Savannah, Georgia
Saint Joseph's-Candler Health System, Savannah, Georgia
Queen's Medical Center, Honolulu, Hawaii
University of Hawaii, Honolulu, Hawaii
Saint Alphonsus Regional Medical Center, Boise, Idaho
Northwestern University, Chicago, Illinois
Rush University Medical Center, Chicago, Illinois
OSF Saint Francis Medical Center, Peoria, Illinois
Saint Vincent Anderson Regional Hospital/Cancer Center, Anderson, Indiana
Saint Francis Hospital and Health Centers, Beech Grove, Indiana
Franciscan Saint Margaret Health-Hammond Campus, Hammond, Indiana
Franciscan Saint Francis Health-Indianapolis, Indianapolis, Indiana
Michiana Hematology Oncology PC-Mishawaka, Mishawaka, Indiana
University of Iowa Hospitals and Clinics, Iowa City, Iowa
Mercy Medical Center - North Iowa, Mason City, Iowa
University of Kansas Medical Center, Kansas City, Kansas
Kansas City Cancer Centers-Southwest, Overland Park, Kansas
Via Christi Regional Medical Center, Wichita, Kansas
University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland
Greater Baltimore Medical Center, Baltimore, Maryland
Sinai Hospital of Baltimore, Baltimore, Maryland
Central Maryland Radiation Oncology in Howard County, Columbia, Maryland
Holy Cross Hospital, Silver Spring, Maryland
Hickman Cancer Center, Adrian, Michigan
Saint John Hospital and Medical Center, Detroit, Michigan
West Michigan Cancer Center, Kalamazoo, Michigan
Saint Joseph Mercy Port Huron, Port Huron, Michigan
Saint John Macomb-Oakland Hospital, Warren, Michigan
Abbott-Northwestern Hospital, Minneapolis, Minnesota
Mayo Clinic, Rochester, Minnesota
University of Mississippi Medical Center, Jackson, Mississippi
Kansas City Cancer Center - South, Kansas City, Missouri
Kansas City Cancer Centers - North, Kansas City, Missouri
Kansas City Cancer Center-Lee's Summit, Lee's Summit, Missouri
Phelps County Regional Medical Center, Rolla, Missouri
Saint John's Mercy Medical Center, Saint Louis, Missouri
Mercy Hospital Springfield, Springfield, Missouri
CoxHealth South Hospital, Springfield, Missouri
Nebraska Methodist Hospital, Omaha, Nebraska
The Nebraska Medical Center, Omaha, Nebraska
Elliot Hospital, Manchester, New Hampshire
Cooper Hospital University Medical Center, Camden, New Jersey
Morristown Memorial Hospital, Morristown, New Jersey
Fox Chase Cancer Center at Virtua Memorial Hospital of Burlington County, Mount Holly, New Jersey
UMDNJ - New Jersey Medical School, Newark, New Jersey
MD Anderson Cancer Center at Cooper-Voorhees, Voorhees, New Jersey
Montefiore Medical Center-Weiler Division, Bronx, New York
Montefiore Medical Center, Bronx, New York
State University of New York Downstate Medical Center, Brooklyn, New York
Memorial Sloan-Kettering Cancer Center, New York, New York
Highland Hospital, Rochester, New York
University of Rochester, Rochester, New York
Carolinas Medical Center, Charlotte, North Carolina
Summa Akron City Hospital/Cooper Cancer Center, Akron, Ohio
Akron General Medical Center, Akron, Ohio
Summa Barberton Hospital, Barberton, Ohio
University of Cincinnati, Cincinnati, Ohio
Case Western Reserve University, Cleveland, Ohio
Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center, Columbus, Ohio
Summa Health Center at Lake Medina, Medina, Ohio
UHHS-Chagrin Highlands Medical Center, Orange Village, Ohio
Southern Ohio Medical Center, Portsmouth, Ohio
Robinson Radiation Oncology, Ravenna, Ohio
Cancer Care Center, Incorporated, Salem, Ohio
Ireland Cancer Center at Firelands Regional Medical Center, Sandusky, Ohio
Flower Hospital, Sylvania, Ohio
University of Toledo, Toledo, Ohio
UHHS-Westlake Medical Center, Westlake, Ohio
Cancer Treatment Center, Wooster, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Providence Portland Medical Center, Portland, Oregon
Providence Saint Vincent Medical Center, Portland, Oregon
Delaware County Memorial Hospital, Drexel Hill, Pennsylvania
Reading Hospital, West Reading, Pennsylvania
Lankenau Hospital, Wynnewood, Pennsylvania
Women and Infants Hospital, Providence, Rhode Island
Rapid City Regional Hospital, Rapid City, South Dakota
Sanford Cancer Center-Oncology Clinic, Sioux Falls, South Dakota
University of Tennessee - Knoxville, Knoxville, Tennessee
University of Texas Southwestern Medical Center, Dallas, Texas
M D Anderson Cancer Center, Houston, Texas
Methodist Hospital, Houston, Texas
Intermountain Medical Center, Murray, Utah
McKay-Dee Hospital Center, Ogden, Utah
Dixie Medical Center Regional Cancer Center, Saint George, Utah
Huntsman Cancer Institute/University of Utah, Salt Lake City, Utah
Seattle Cancer Care Alliance, Seattle, Washington
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital, Yakima, Washington
Wheeling Hospital, Wheeling, West Virginia
Saint Vincent Hospital, Green Bay, Wisconsin
Aurora Saint Luke's Medical Center, Milwaukee, Wisconsin
Froedtert and the Medical College of Wisconsin, Milwaukee, Wisconsin
Aurora West Allis Medical Center, West Allis, Wisconsin
McGill University Department of Oncology, Montreal, Quebec
Pamela Youde Nethersole Eastern Hospital, Chai Wan, Not set
Seoul National University Bundang Hospital, Seongnam City, Kyeonggi-do
Seoul National University Hospital, Seoul, Not set
Gangnam Severance Hospital, Seoul, Not set
Korea Cancer Center Hospital, Seoul, Not set
Conditions: Cervical Cancer
9-ING-41 in Patients with Advanced Cancers
Active Not Recruiting
GSK-3β is a potentially important therapeutic target in human malignancies. The Actuate 1801 Phase 1/2 study is designed to evaluate the safety and efficacy of 9-ING-41, a potent GSK-3β inhibitor, as a single agent and in combination with cytotoxic agents, in patients with refractory cancers.
GSK-3β is a potentially important therapeutic target in human malignancies. The Actuate 1801 Phase 1/2 study is designed to evaluate the safety and efficacy of 9-ING-41, a potent GSK-3β inhibitor, as a single agent and in combination with cytotoxic agents, in patients with refractory cancers. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/06/2024
Locations: Mayo Clinic, Phoenix, Arizona +65 locations
Mayo Clinic, Phoenix, Arizona
Arizona Oncology Associates, Tucson, Arizona
The University of Arizona Cancer Center, Tucson, Arizona
University of California Irvine Health, Orange, California
UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California
Christiana Care Health Services, Newark, Delaware
Sibley Memorial Hospital, Washington, District of Columbia
Florida Cancer Specialists - South, Fort Myers, Florida
Miami Cancer Institute, Miami, Florida
Florida Cancer Specialists - North, Saint Petersburg, Florida
Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois
Des Moines Oncology Research Association, Des Moines, Iowa
Kansas University Cancer Center, Kansas City, Kansas
Ochsner Clinic Foundation, New Orleans, Louisiana
University of Michigan, Ann Arbor, Michigan
MetroMetro-Minnesota Community Oncology Research Consortium (MMCORC), Minneapolis, Minnesota
Mayo Clinic, Rochester, Minnesota
Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada
Morristown Medical Center, Morristown, New Jersey
Capital Health Medical Center/ Hopewell, Pennington, New Jersey
MD Anderson Cancer Center at Cooper, Voorhees, New Jersey
Columbia University- Irving Medical Center, New York, New York
Stony Brook University Hospital, Stony Brook, New York
Duke University Medical Center, Durham, North Carolina
Oregon Health and Science University, Portland, Oregon
St. Luke's University Health Network, Bethlehem, Pennsylvania
Allegheny Health Network, Pittsburgh, Pennsylvania
Rhode Island Hospital, Providence, Rhode Island
Prisma Health Cancer Institute, Greenville, South Carolina
Sanford Research, Sioux Falls, South Dakota
West Cancer Center, Germantown, Tennessee
Baptist Clinical Research Institute, Memphis, Tennessee
Sarah Cannon Research Institute- Tennessee Oncology-Nashville, Nashville, Tennessee
Vanderbilt-Ingram Cancer Center, Nashville, Tennessee
Texas Oncology- Charles A. Sammons Cancer Center, Dallas, Texas
UT Southwestern Medical Center, Dallas, Texas
Utah Cancer Specialists, Salt Lake City, Utah
Fred Hutchinson Cancer Research Center, Seattle, Washington
West Virginia University, Morgantown, West Virginia
UW Carbone Cancer Center, Madison, Wisconsin
UZA- Antwerpen, Edegem, Antwerp
Imelda VZW, Bonheiden, Not set
UZ Gent, Gent, Not set
UZ Leuven Gasthuisberg, Leuven, Not set
Cross Cancer Institute, Edmonton, Alberta
QE II Health Sciences Centre, Halifax, Nova Scotia
Centre Intégré de Santé et de Services Sociaux de la Montérégie-Centre, Greenfield Park, Quebec
Jewish General Hospital, Montréal, Quebec
McGill University Health Centre, Montréal, Quebec
Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec
Center Hospitalier Regional Universitaire de Besancon - Site Jean Minjoz, Besançon, Bourgogne-Franche-Comte
CHRU Brest Hopital Morvan, Brest, Bretagne
Hopital Claude Huriez, Lille, Hauts de France
Institute de Cancerologie de Lorraine, Vandœuvre-lès-Nancy, Meurthe-et-Moselle
Institut Bergonie, Bordeaux, Nouvelle Aquitaine
Insitut de Cancerologie de l'Ouest, Saint-Herblain, Pays-de-la-Loire
Hopital de la Timone, Marseille, Not set
Netherlands Cancer Institute, Amsterdam, Not set
Fundacao Champalimaud, Lisbon, Not set
Hospital Da Luz, Lisbon, Not set
Centro Hospitalar Universitario Sao Joao, Porto, Not set
Vall d'Hebron Institute of Oncology, Barcelona, Not set
Institut Catala d'Oncologia, Barcelona, Not set
Hospital Clinico U San Carlos (HSC), Madrid, Not set
START Madrid-HM CIOCC Hospital Universitario, Madrid, Not set
INCLIVA University of Valencia, Valencia, Not set
Conditions: Cancer, Pancreatic Cancer, Sarcoma, Renal Cancer, Refractory Cancer, Refractory Neoplasm, Refractory Non-Hodgkin Lymphoma, Pancreatic Adenocarcinoma, Resistant Cancer, Neoplasm Metastasis, Neoplasm of Bone, Neoplasm, Breast, Neoplasm of Lung, Neoplasms,Colorectal, Neoplasms Pancreatic, Malignant Glioma, Malignancies, Malignancies Multiple, Bone Metastases, Bone Neoplasm, Bone Cancer, Pancreas Cancer, Pancreatic Neoplasms, Breast Neoplasms, Acute T Cell Leukemia Lymphoma
Study of Pemetrexed + Platinum Chemotherapy With or Without Pembrolizumab (MK-3475) in Adults With Tyrosine Kinase Inhibitor- (TKI)-Resistant Epidermal Growth Factor Receptor- (EGFR)-Mutated Metastatic Non-squamous Non-small Cell Lung Cancer (NSCLC) (MK-3475-789/KEYNOTE-789)
Completed
The purpose of this study is to evaluate the efficacy and safety of pemetrexed plus platinum chemotherapy (carboplatin or cisplatin) with or without pembrolizumab (MK-3475; KEYTRUDA®) in the treatment of adults with the following types of tyrosine kinase inhibitor (TKI)-resistant, epidermal growth factor receptor (EGFR)-mutated, metastatic non-squamous non-small cell lung cancer (NSCLC) tumors: 1) TKI-failures (including osimertinib \[TAGRISSO®\] failure) with T790M-negative mutation tumors, 2)... Read More
The purpose of this study is to evaluate the efficacy and safety of pemetrexed plus platinum chemotherapy (carboplatin or cisplatin) with or without pembrolizumab (MK-3475; KEYTRUDA®) in the treatment of adults with the following types of tyrosine kinase inhibitor (TKI)-resistant, epidermal growth factor receptor (EGFR)-mutated, metastatic non-squamous non-small cell lung cancer (NSCLC) tumors: 1) TKI-failures (including osimertinib \[TAGRISSO®\] failure) with T790M-negative mutation tumors, 2) T790M-positive mutation tumors with prior exposure to osimertinib, and 3) first-line osimertinib failure regardless of T790M mutation status.
The primary study hypotheses are that the combination of pembrolizumab plus chemotherapy has superior efficacy compared to saline placebo plus chemotherapy in terms of: 1) Progression-free Survival (PFS) per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1) based on blinded independent central review, and 2) Overall Survival (OS). This study will be considered to have met its success criteria if the combination of pembrolizumab plus chemotherapy is superior to saline placebo plus chemotherapy in terms of PFS or OS.
Upon study completion, participants are discontinued and may be enrolled in a pembrolizumab extension study, if available. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/05/2024
Locations: Cedars-Sinai Medical Center ( Site 0070), Los Angeles, California +157 locations
Cedars-Sinai Medical Center ( Site 0070), Los Angeles, California
Pacific Cancer Care ( Site 0058), Monterey, California
UC Irvine Medical Center/Chao Family Comprehensive Cancer Center ( Site 0092), Orange, California
St. Joseph Heritage Healthcare ( Site 0003), Santa Rosa, California
North Shore University Health System ( Site 0030), Evanston, Illinois
Siouxland Regioinal Cancer Center dba June E. Nylen Cancer Center ( Site 0065), Sioux City, Iowa
Southdale Cancer Care, University of Minnesota Medical Center- Edina ( Site 0048), Edina, Minnesota
Saint Lukes Hospital of Kansas City ( Site 0060), Kansas City, Missouri
New York Oncology Hematology P.C ( Site 8000), Albany, New York
Monter Cancer Center ( Site 0054), Lake Success, New York
Memorial Sloan Kettering Cancer Center-Rockerfeller Patient Pavilion ( Site 0049), New York, New York
White Plains Hospital Center for Cancer Care ( Site 0014), White Plains, New York
Providence Portland Medical Center ( Site 0097), Portland, Oregon
Kaiser Permanente Northwest ( Site 0037), Portland, Oregon
Parkland Health & Hospital System ( Site 2102), Dallas, Texas
University of Texas Southwestern Medical Center at Dallas ( Site 0035), Dallas, Texas
Utah Cancer Specialists ( Site 0001), Salt Lake City, Utah
Emily Couric Clinical Cancer Center ( Site 0020), Charlottesville, Virginia
Froedtert Hospital & the Medical College of Wisconsin ( Site 0041), Milwaukee, Wisconsin
Chris OBrien Lifehouse ( Site 0200), Camperdown, New South Wales
Westmead Hospital ( Site 0201), Westmead, New South Wales
Eastern Health ( Site 0202), Box Hill, Victoria
Austin Health ( Site 0203), Heidelberg, Victoria
Liga Norte Riograndense Contra o Cancer ( Site 1909), Natal, Rio Grande Do Norte
Hospital de Caridade de Ijui ( Site 1907), Ijui, Rio Grande Do Sul
Hospital Bruno Born ( Site 1913), Lajeado, Rio Grande Do Sul
Hospital de Clinicas de Porto Alegre ( Site 1905), Porto Alegre, Rio Grande Do Sul
Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da Pucrs ( Site 1904), Porto Alegre, Rio Grande Do Sul
Fundacao Pio XII - Hospital de Cancer de Barretos ( Site 1911), Barretos, Sao Paulo
Hosp. Clinicas da Fac. de Medicina de Ribeirao Preto - USP ( Site 1912), Ribeirao Preto, Sao Paulo
Instituto do Cancer do Estado de Sao Paulo - ICESP ( Site 1903), Sao Paulo, Not set
William Osler Health System ( Site 0100), Brampton, Ontario
Sunnybrook Health Sciences, Odette Cancer Centre ( Site 0102), Toronto, Ontario
Princess Margaret Cancer Centre ( Site 0104), Toronto, Ontario
Jewish General Hospital ( Site 0105), Montreal, Quebec
The First Affiliated Hospital of Anhui Medical University ( Site 0721), Hefei, Anhui
Cancer Hospital Chinese Academy of Medical Sciences ( Site 0717), Beijing, Beijing
Peking Union Medical College Hospital ( Site 0703), Beijing, Beijing
Beijing Cancer Hospital ( Site 0718), Beijing, Beijing
Southwest Hospital, The Third Military Medical University ( Site 0725), Chongqing, Chongqing
Fujian Cancer Hospital ( Site 0723), Fuzhou, Fujian
The Affiliated Tumour Hospital of Harbin Medical University ( Site 0706), Harbin, Heilongjiang
Henan Cancer Hospital ( Site 0711), Zhengzhou, Henan
Xiangya Hospital of Central South University ( Site 0710), Changsha, Hunan
Hunan Cancer Hospital ( Site 0722), Changsha, Hunan
Jiangsu Cancer Hospital ( Site 0719), Nanjing, Jiangsu
The First Hospital of Jilin University ( Site 0702), Chang chun, Jilin
Jilin Cancer Hospital ( Site 0705), Changchun, Jilin
Shanghai Chest Hospital ( Site 0700), Shanghai, Shanghai
Zhongshan Hospital Fudan University ( Site 0712), Shanghai, Shanghai
Tangdu Hospital ( Site 0708), XI An, Shanxi
The First Affiliated Hospital of Xi an Jiaotong University ( Site 0709), XI An, Shanxi
Affiliated Tumor Hospital of Xinjiang Medical University ( Site 0701), Urumqi, Xinjiang
The First Affiliated Hospital.Zhejiang University ( Site 0713), Hangzhou, Zhejiang
Sir Run Run Shaw Hospital School of Medicine, Zhejiang University ( Site 0715), Hangzhou, Zhejiang
Zhejiang Cancer Hospital ( Site 0716), Hangzhou, Zhejiang
Centre Leon Berard ( Site 0801), Lyon, Auvergne
CHU Caen Service de Pneumologie ( Site 0804), Caen, Calvados
Centre Georges Francois Leclerc ( Site 0809), Dijon, Cote-d'Or
Hopital Jean Minjoz Besancon ( Site 0805), Besancon, Doubs
Hopital Prive d'Antony ( Site 0811), Antony, Hauts-de-Seine
C.H.U. de Tours - Hopital Bretonneau ( Site 0806), Tours, Indre-et-Loire
Centre D Oncologie de Gentilly ( Site 0810), Nancy, Meurthe-et-Moselle
Clinique Victor Hugo ( Site 0802), Le Mans, Sarthe
CHU Poitiers ( Site 0803), Poitiers, Vienne
Robert Bosch Krankenhaus Klinik Schillerhoehe ( Site 0904), Gerlingen, Baden-Wurttemberg
Universitaetsklinikum Mannheim ( Site 0911), Mannheim, Baden-Wurttemberg
Klinikum Wuerzburg Mitte gGmbH ( Site 0901), Wuerzburg, Bayern
Pius Hospital Oldenburg ( Site 0905), Oldenburg, Niedersachsen
Florence Nightingale Krankenhaus ( Site 0912), Duesseldorf, Nordrhein-Westfalen
Kliniken Essen-Mitte ( Site 0900), Essen, Nordrhein-Westfalen
Universitaetsklinikum Muenster ( Site 0906), Muenster, Nordrhein-Westfalen
Medizinische Fakultaet Carl Gustav Carus der TU Dresden ( Site 0907), Dresden, Sachsen
Asklepios Klinikum Hamburg ( Site 0908), Hamburg, Not set
Hong Kong Integrated Oncology Centre ( Site 0304), Hong Kong, Not set
Queen Mary Hospital ( Site 0301), Hong Kong, Not set
Queen Mary Hospital ( Site 0303), Hong Kong, Not set
Hong Kong United Oncology Centre ( Site 0306), Kowloon, Not set
Tuen Mun Hospital ( Site 0305), Tuen Mun, Not set
Barzilai Medical Center ( Site 1706), Ashkelon, HaDarom
Soroka Medical Center ( Site 1702), Beer-Sheva, HaDarom
Meir Medical Center ( Site 1701), Kfar-Saba, HaMerkaz
Rabin Medical Center ( Site 1704), Petah Tikva, HaMerkaz
Ha Emek Medical Center ( Site 1707), Afula, HaTsafon
Rambam Medical Center ( Site 1703), Haifa, Heifa
Chaim Sheba Medical Center. ( Site 1700), Ramat Gan, Tell Abib
Sourasky Medical Center ( Site 1705), Tel Aviv, Tell Abib
Istituto Europeo di Oncologia ( Site 1303), Milano, Lombardia
Ospedale San Vincenzo di Taormina ( Site 1302), Taormina, Messina
AOU San Luigi Gonzaga di Orbassano ( Site 1300), Orbassano, Torino
IRCCS Giovanni Paolo II. Ospedale Oncologico ( Site 1305), Bari, Not set
Azienda Ospedaliero Universitaria Careggi ( Site 1301), Firenze, Not set
Azienda Ospedaliera dei Colli V. Monaldi ( Site 1306), Napoli, Not set
Universita Campus Bio-Medico di Roma ( Site 1304), Roma, Not set
National Hospital Organization Nagoya Medical Center ( Site 0608), Nagoya, Aichi
Aichi Cancer Center Hospital ( Site 0612), Nagoya, Aichi
Fujita Health University Hospital ( Site 0619), Toyoake, Aichi
National Cancer Center Hospital East ( Site 0601), Kashiwa, Chiba
National Hospital Organization Shikoku Cancer Center ( Site 0616), Matsuyama, Ehime
Hyogo Cancer Center ( Site 0604), Akashi, Hyogo
Kanazawa University Hospital ( Site 0617), Kanazawa, Ishikawa
Kanagawa Cancer Center ( Site 0609), Yokohama, Kanagawa
Kansai Medical University Hospital ( Site 0606), Hirakata, Osaka
Shizuoka Cancer Center Hospital and Research Institute ( Site 0602), Sunto-gun, Shizuoka
National Hospital Organization Kyushu Medical Center ( Site 0621), Fukuoka, Not set
Kyushu University Hospital ( Site 0605), Fukuoka, Not set
Niigata Cancer Center Hospital ( Site 0610), Niigata, Not set
Okayama University Hospital ( Site 0614), Okayama, Not set
Osaka International Cancer Institute ( Site 0611), Osaka, Not set
National Cancer Center Hospital ( Site 0603), Tokyo, Not set
Toranomon Hospital ( Site 0615), Tokyo, Not set
Tokyo Metropolitan Komagome Hospital ( Site 0618), Tokyo, Not set
Wakayama Medical University Hospital ( Site 0613), Wakayama, Not set
Chungbuk National University Hospital ( Site 0404), Cheongju si, Chungcheongbuk-do [Chungbuk]
Gachon University Gil Medical Center ( Site 0408), Incheon, Incheon-gwangyeoksi [Incheon]
National Cancer Center ( Site 0400), Gyeonggi-do, Kyonggi-do
Seoul National University Bundang Hospital ( Site 0405), Seongnam-si, Kyonggi-do
Seoul National University Hospital ( Site 0402), Seoul, Seoul-teukbyeolsi [Seoul]
Asan Medical Center ( Site 0407), Seoul, Seoul-teukbyeolsi [Seoul]
Samsung Medical Center ( Site 0403), Seoul, Seoul-teukbyeolsi [Seoul]
The Catholic University of Korea. Seoul St. Mary s Hospital ( Site 0406), Seoul, Seoul-teukbyeolsi [Seoul]
Ulsan University Hospital ( Site 0401), Ulsan, Ulsan-Kwangyokshi
Instituto Jaliscience de Cancerologia ( Site 2000), Guadalajara, Jalisco
Medica Sur S.A.B de C.V. ( Site 2003), Mexico City, Not set
Oaxaca Site Management Organization SC ( Site 2001), Oaxaca, Not set
Instituto Nacional de Cancerologia. ( Site 2007), Tlalpan, Not set
Hospitalo Univ. Germans Trias i Pujol ( Site 1100), Badalona, Barcelona [Barcelona]
Hospital de la Santa Creu i Sant Pau ( Site 1102), Barcelona, Barcelona [Barcelona]
Hospital Universitari Vall d Hebron ( Site 1106), Barcelona, Barcelona [Barcelona]
Hospital Ramon y Cajal ( Site 1101), Madrid, Not set
Hospital Universitario 12 de Octubre ( Site 1103), Madrid, Not set
Complejo Hospitalario Carlos Haya de Malaga ( Site 1107), Malaga, Not set
Hospital Universitario Virgen Macarena ( Site 1104), Sevilla, Not set
Linkopings Universitetssjukhus ( Site 1504), Linkoping, Ostergotlands Lan [se-05]
Skanes Universitetssjukhus Lund ( Site 1503), Lund, Skane Lan [se-12]
Karolinska Universitetssjukhuset Solna ( Site 1500), Solna, Stockholms Lan [se-01]
Sahlgrenska Universitetssjukhuset ( Site 1502), Goteborg, Vastra Gotalands Lan [se-14]
Taipei Tzu Chi Hospital ( Site 0512), New Taipei City, New Taipei
Changhua Christian Hospital ( Site 0509), Changhua, Not set
National Taiwan University Hospital Hsin-Chu Branch ( Site 0511), Hsinchu, Not set
Hualien Tzu Chi Medical Center-Hospital ( Site 0510), Hualien, Not set
Kaohsiung Chang Gung Memorial Hospital ( Site 0507), Kaohsiung, Not set
Taipei Medical University Shuang Ho Hospital ( Site 0508), New Taipei, Not set
China Medical University Hospital ( Site 0505), Taichung, Not set
Taichung Veterans General Hospital ( Site 0504), Taichung, Not set
National Cheng Kung University Hospital ( Site 0506), Tainan, Not set
National Taiwan University Hospital ( Site 0500), Taipei, Not set
Mackay Memorial Hospital ( Site 0503), Taipei, Not set
Taipei Veterans General Hospital ( Site 0501), Taipei, Not set
Chang Gung Medical Foundation. Linkou ( Site 0502), Taoyuan, Not set
Sussex University Hospitals ( Site 1003), Brighton, Brighton And Hove
Western General Hospital ( Site 1009), Edinburgh, Edinburgh, City Of
Leicester Royal Infirmary ( Site 1000), Leicester, Leicestershire
University College London Hospitals NHS Foundation Trust ( Site 1006), London, London, City Of
Chelsea & Westminster Hospital ( Site 1001), London, London, City Of
Birmingham Heartlands Hospital ( Site 1002), Birmingham, Not set
St James s University Hospital ( Site 1008), Leeds, Not set
Barking Havering and Redbridge University Hospitals NHS Trust Queen s Hospital ( Site 1004), Romford, Not set
Conditions: Non-small Cell Lung Cancer
PLX2853 as a Single Agent in Advanced Gynecological Malignancies and in Combination With Carboplatin in Platinum-Resistant Epithelial Ovarian Cancer
Terminated
The purpose of this research study is to evaluate safety, pharmacokinetics, pharmacodynamics and preliminary efficacy of the investigational drug PLX2853 in Advanced Gynecological Malignancies with a Known ARID1A Mutation and PLX2853/Carboplatin Combination Therapy in Platinum-Resistant Epithelial Ovarian Cancer.
The purpose of this research study is to evaluate safety, pharmacokinetics, pharmacodynamics and preliminary efficacy of the investigational drug PLX2853 in Advanced Gynecological Malignancies with a Known ARID1A Mutation and PLX2853/Carboplatin Combination Therapy in Platinum-Resistant Epithelial Ovarian Cancer. Read Less
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
10/30/2024
Locations: The University of Chicago Medical Center, Chicago, Illinois +8 locations
The University of Chicago Medical Center, Chicago, Illinois
Massachusetts General Hospital, Boston, Massachusetts
Memorial Sloan Kettering Cancer Center, New York, New York
University of Oklahoma - Stephenson Cancer Center, Oklahoma City, Oklahoma
Tennessee Oncology / Sarah Cannon, Nashville, Tennessee
University of Virginia Health Systems, Charlottesville, Virginia
Virginia Cancer Specialists, PC, Fairfax, Virginia
University of Washington / Seattle Cancer Care Alliance, Seattle, Washington
Princess Margaret Cancer Centre, Toronto, Ontario
Conditions: Gynecologic Neoplasms, Epithelial Ovarian Cancer
Chemotherapy Followed by Radiation Therapy in Treating Younger Patients With Newly Diagnosed Localized Central Nervous System Germ Cell Tumors
Completed
This phase II trial studies how well chemotherapy followed by radiation therapy work in treating younger patients with newly diagnosed central nervous system germ cell tumors that have not spread to other parts of the brain, spinal canal, or body (localized). Drugs used as chemotherapy, such as carboplatin, etoposide, and ifosfamide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation... Read More
This phase II trial studies how well chemotherapy followed by radiation therapy work in treating younger patients with newly diagnosed central nervous system germ cell tumors that have not spread to other parts of the brain, spinal canal, or body (localized). Drugs used as chemotherapy, such as carboplatin, etoposide, and ifosfamide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high-energy x rays to kill tumor cells. Giving chemotherapy followed by radiation therapy may kill more tumor cells. Read Less
Gender:
ALL
Ages:
Between 3 years and 21 years
Trial Updated:
10/28/2024
Locations: Children's Hospital of Alabama, Birmingham, Alabama +166 locations
Children's Hospital of Alabama, Birmingham, Alabama
University of Alabama at Birmingham Cancer Center, Birmingham, Alabama
Phoenix Childrens Hospital, Phoenix, Arizona
Kaiser Permanente Downey Medical Center, Downey, California
Miller Children's and Women's Hospital Long Beach, Long Beach, California
Children's Hospital Los Angeles, Los Angeles, California
Cedars Sinai Medical Center, Los Angeles, California
Mattel Children's Hospital UCLA, Los Angeles, California
Valley Children's Hospital, Madera, California
UCSF Benioff Children's Hospital Oakland, Oakland, California
Kaiser Permanente-Oakland, Oakland, California
Children's Hospital of Orange County, Orange, California
Lucile Packard Children's Hospital Stanford University, Palo Alto, California
Sutter Medical Center Sacramento, Sacramento, California
Rady Children's Hospital - San Diego, San Diego, California
UCSF Medical Center-Parnassus, San Francisco, California
UCSF Medical Center-Mission Bay, San Francisco, California
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California
Children's Hospital Colorado, Aurora, Colorado
Connecticut Children's Medical Center, Hartford, Connecticut
Yale University, New Haven, Connecticut
Alfred I duPont Hospital for Children, Wilmington, Delaware
MedStar Georgetown University Hospital, Washington, District of Columbia
Children's National Medical Center, Washington, District of Columbia
Lee Memorial Health System, Fort Myers, Florida
Golisano Children's Hospital of Southwest Florida, Fort Myers, Florida
University of Florida Health Science Center - Gainesville, Gainesville, Florida
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood, Florida
Nemours Children's Clinic-Jacksonville, Jacksonville, Florida
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida
Nicklaus Children's Hospital, Miami, Florida
AdventHealth Orlando, Orlando, Florida
Arnold Palmer Hospital for Children, Orlando, Florida
Nemours Children's Clinic - Orlando, Orlando, Florida
Orlando Health Cancer Institute, Orlando, Florida
Nemours Children's Hospital, Orlando, Florida
Nemours Children's Clinic - Pensacola, Pensacola, Florida
Johns Hopkins All Children's Hospital, Saint Petersburg, Florida
Tampa General Hospital, Tampa, Florida
Saint Mary's Hospital, West Palm Beach, Florida
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia
Memorial Health University Medical Center, Savannah, Georgia
University of Hawaii Cancer Center, Honolulu, Hawaii
Kapiolani Medical Center for Women and Children, Honolulu, Hawaii
Saint Luke's Cancer Institute - Boise, Boise, Idaho
Lurie Children's Hospital-Chicago, Chicago, Illinois
University of Illinois, Chicago, Illinois
University of Chicago Comprehensive Cancer Center, Chicago, Illinois
Loyola University Medical Center, Maywood, Illinois
Advocate Children's Hospital-Oak Lawn, Oak Lawn, Illinois
Advocate Children's Hospital-Park Ridge, Park Ridge, Illinois
Saint Jude Midwest Affiliate, Peoria, Illinois
Riley Hospital for Children, Indianapolis, Indiana
Ascension Saint Vincent Indianapolis Hospital, Indianapolis, Indiana
Blank Children's Hospital, Des Moines, Iowa
University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa
University of Kentucky/Markey Cancer Center, Lexington, Kentucky
Norton Children's Hospital, Louisville, Kentucky
Children's Hospital New Orleans, New Orleans, Louisiana
University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland
Walter Reed National Military Medical Center, Bethesda, Maryland
Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Dana-Farber Cancer Institute, Boston, Massachusetts
Wayne State University/Karmanos Cancer Institute, Detroit, Michigan
Michigan State University Clinical Center, East Lansing, Michigan
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids, Michigan
Bronson Methodist Hospital, Kalamazoo, Michigan
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis, Minnesota
Mayo Clinic in Rochester, Rochester, Minnesota
University of Mississippi Medical Center, Jackson, Mississippi
Children's Mercy Hospitals and Clinics, Kansas City, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Mercy Hospital Saint Louis, Saint Louis, Missouri
University Medical Center of Southern Nevada, Las Vegas, Nevada
Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas, Nevada
Summerlin Hospital Medical Center, Las Vegas, Nevada
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire
Hackensack University Medical Center, Hackensack, New Jersey
Saint Barnabas Medical Center, Livingston, New Jersey
Morristown Medical Center, Morristown, New Jersey
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick, New Jersey
Newark Beth Israel Medical Center, Newark, New Jersey
Overlook Hospital, Summit, New Jersey
University of New Mexico Cancer Center, Albuquerque, New Mexico
Albany Medical Center, Albany, New York
Montefiore Medical Center - Moses Campus, Bronx, New York
Roswell Park Cancer Institute, Buffalo, New York
NYU Langone Hospital - Long Island, Mineola, New York
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York
Memorial Sloan Kettering Cancer Center, New York, New York
University of Rochester, Rochester, New York
State University of New York Upstate Medical University, Syracuse, New York
New York Medical College, Valhalla, New York
Mission Hospital, Asheville, North Carolina
UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina
Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina
Novant Health Presbyterian Medical Center, Charlotte, North Carolina
Duke University Medical Center, Durham, North Carolina
Wake Forest University Health Sciences, Winston-Salem, North Carolina
Sanford Broadway Medical Center, Fargo, North Dakota
Children's Hospital Medical Center of Akron, Akron, Ohio
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Rainbow Babies and Childrens Hospital, Cleveland, Ohio
Cleveland Clinic Foundation, Cleveland, Ohio
Nationwide Children's Hospital, Columbus, Ohio
Dayton Children's Hospital, Dayton, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Legacy Emanuel Children's Hospital, Portland, Oregon
Oregon Health and Science University, Portland, Oregon
Lehigh Valley Hospital-Cedar Crest, Allentown, Pennsylvania
Lehigh Valley Hospital - Muhlenberg, Bethlehem, Pennsylvania
Penn State Children's Hospital, Hershey, Pennsylvania
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
Prisma Health Richland Hospital, Columbia, South Carolina
BI-LO Charities Children's Cancer Center, Greenville, South Carolina
Greenville Cancer Treatment Center, Greenville, South Carolina
Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota
T C Thompson Children's Hospital, Chattanooga, Tennessee
East Tennessee Childrens Hospital, Knoxville, Tennessee
Saint Jude Children's Research Hospital, Memphis, Tennessee
Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee
Dell Children's Medical Center of Central Texas, Austin, Texas
Driscoll Children's Hospital, Corpus Christi, Texas
Medical City Dallas Hospital, Dallas, Texas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas
Cook Children's Medical Center, Fort Worth, Texas
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas
M D Anderson Cancer Center, Houston, Texas
UMC Cancer Center / UMC Health System, Lubbock, Texas
Children's Hospital of San Antonio, San Antonio, Texas
Methodist Children's Hospital of South Texas, San Antonio, Texas
University of Texas Health Science Center at San Antonio, San Antonio, Texas
Primary Children's Hospital, Salt Lake City, Utah
University of Virginia Cancer Center, Charlottesville, Virginia
Inova Fairfax Hospital, Falls Church, Virginia
Children's Hospital of The King's Daughters, Norfolk, Virginia
Virginia Commonwealth University/Massey Cancer Center, Richmond, Virginia
Carilion Children's, Roanoke, Virginia
Seattle Children's Hospital, Seattle, Washington
Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington
Madigan Army Medical Center, Tacoma, Washington
Saint Vincent Hospital Cancer Center Green Bay, Green Bay, Wisconsin
University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin
Marshfield Medical Center-Marshfield, Marshfield, Wisconsin
Children's Hospital of Wisconsin, Milwaukee, Wisconsin
John Hunter Children's Hospital, Hunter Regional Mail Centre, New South Wales
Sydney Children's Hospital, Randwick, New South Wales
The Children's Hospital at Westmead, Westmead, New South Wales
Royal Children's Hospital-Brisbane, Herston, Queensland
Queensland Children's Hospital, South Brisbane, Queensland
Women's and Children's Hospital-Adelaide, North Adelaide, South Australia
Royal Children's Hospital, Parkville, Victoria
Princess Margaret Hospital for Children, Perth, Western Australia
Perth Children's Hospital, Perth, Western Australia
British Columbia Children's Hospital, Vancouver, British Columbia
CancerCare Manitoba, Winnipeg, Manitoba
IWK Health Centre, Halifax, Nova Scotia
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton, Ontario
Hospital for Sick Children, Toronto, Ontario
Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec
Starship Children's Hospital, Grafton, Auckland
Christchurch Hospital, Christchurch, Not set
University Pediatric Hospital, San Juan, Not set
Conditions: Central Nervous System Nongerminomatous Germ Cell Tumor, Childhood Central Nervous System Germinoma
Study of Nivolumab in Combination With Ipilimumab or Standard of Care Chemotherapy Compared to the Standard of Care Chemotherapy Alone in Treatment of Participants With Untreated Inoperable or Metastatic Urothelial Cancer
Active Not Recruiting
The purpose of this study is to determine whether an investigational immunotherapy nivolumab in combination with ipilimumab or in combination with standard of care chemotherapy is more effective than standard of care chemotherapy alone in treating participants with previously untreated inoperable or metastatic urothelial cancer.
The purpose of this study is to determine whether an investigational immunotherapy nivolumab in combination with ipilimumab or in combination with standard of care chemotherapy is more effective than standard of care chemotherapy alone in treating participants with previously untreated inoperable or metastatic urothelial cancer. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/22/2024
Locations: Local Institution - 0001, Anchorage, Alaska +173 locations
Local Institution - 0001, Anchorage, Alaska
Local Institution - 0115, Fresno, California
St Joseph Heritage Healthcare, Santa Rosa, California
Local Institution - 0051, Boca Raton, Florida
Local Institution - 0087, Fort Lauderdale, Florida
Local Institution - 0062, Jacksonville, Florida
Local Institution - 0004, Athens, Georgia
Local Institution - 0033, Thomasville, Georgia
Local Institution - 0046, Chicago, Illinois
Local Institution - 0117, New Orleans, Louisiana
Local Institution - 0056, Boston, Massachusetts
Local Institution - 0073, Boston, Massachusetts
Local Institution - 0208, Boston, Massachusetts
Local Institution - 0207, Milford, Massachusetts
Local Institution - 0063, Ann Arbor, Michigan
Local Institution - 0002, Burnsville, Minnesota
Hattiesburg Clinic, Hattiesburg, Mississippi
Local Institution - 0032, Kansas City, Missouri
Local Institution - 0095, Saint Louis, Missouri
Local Institution - 0057, Manchester, New Hampshire
Local Institution - 0084, Albuquerque, New Mexico
Local Institution - 0083, Buffalo, New York
Local Institution - 0014, Mineola, New York
Local Institution - 0072, New York, New York
Local Institution - 0116, Durham, North Carolina
Local Institution - 0082, Columbus, Ohio
Local Institution - 0104, Portland, Oregon
Local Institution - 0013, Pittsburgh, Pennsylvania
Local Institution - 0086, Kirkland, Washington
Local Institution - 0005, Capital Federal, Buenos Aires
Local Institution - 0007, Mar Del Plata, Buenos Aires
Local Institution - 0008, Viedma, RIO Negro
Local Institution - 0009, Buenos Aires, Not set
Local Institution - 0134, Cordoba, Not set
Local Institution - 0006, Cordoba, Not set
Local Institution - 0096, Waratah, New South Wales
Local Institution - 0099, Westmead, New South Wales
Local Institution - 0188, South Brisbane, Queensland
Local Institution - 0120, Tugun, Queensland
Local Institution - 0101, Heidelberg, Victoria
Local Institution - 0100, Doubleview, Western Australia
Local Institution - 0017, Brasilia, Distrito Federal
Local Institution - 0021, Ijui, RIO Grande DO SUL
Local Institution - 0119, Passo Fundo, RIO Grande DO SUL
Local Institution - 0020, Porto Alegre, RIO Grande DO SUL
Local Institution - 0016, Florianopolis, Santa Catarina
Local Institution - 0018, Barretos, Sao Paulo
Local Institution - 0019, Sao Jose Do Rio Preto, Sao Paulo
Local Institution - 0053, Halifax, Nova Scotia
Local Institution - 0064, London, Ontario
Local Institution - 0054, Quebec City, Quebec
Local Institution - 0052, Sherbrooke, Quebec
Local Institution - 0010, Santiago, Metropolitana
Local Institution - 0012, Vina del Mar, Valparaiso
Local Institution - 0106, Vitacura, Not set
Local Institution - 0171, Beijing, Beijing
Local Institution - 0169, Beijing, Beijing
Local Institution - 0182, Chongqing, Chongqing
Local Institution - 0217, Guiyang, Guizhou
Local Institution - 0219, Harbin, Heilongjiang
Local Institution - 0180, Wuhan, Hubei
Local Institution - 0177, Nanjing, Jiangsu
Local Institution - 0176, Nanjing, Jiangsu
Local Institution - 0175, Nanjng, Jiangsu
Local Institution - 0186, Changchun, Jilin
Local Institution - 0220, Taiyuan, Shan1xi
Local Institution - 0216, Yantai, Shandong
Local Institution - 0167, Shanghai, Shanghai
Local Institution - 0162, Shanghai, Shanghai
Local Institution - 0163, Shanghai, Shanghai
Local Institution - 0184, Chengdu, Sichuan
Local Institution - 0173, Hangzhou, Zhejiang
Local Institution - 0174, Hangzhou, Zhejiang
Local Institution - 0172, Hangzhou, Zhejiang
Local Institution - 0170, Beijing, Not set
Local Institution - 0164, Shanghai, Not set
Local Institution - 0160, Brno, Not set
Local Institution - 0152, Hradec Kralove, Not set
Local Institution - 0190, Aalborg, Not set
Local Institution - 0196, Herlev, Not set
Local Institution - 0060, Helsinki, Not set
Local Institution - 0091, Nîmes, Gard
Local Institution - 0089, Lille, Not set
Local Institution - 0088, Marseille Cedex 9, Not set
Local Institution - 0090, St Priest En Jarez, Not set
Local Institution - 0092, Suresnes, Not set
Local Institution - 0093, Tours Cedex, Not set
Local Institution - 0094, Villejuif, Not set
Local Institution - 0036, Dresden, Not set
Local Institution - 0048, Essen, Not set
Local Institution - 0047, Freiburg, Not set
Local Institution - 0049, Hamburg, Not set
Local Institution - 0037, Hannover, Not set
Local Institution - 0041, Jena, Not set
Local Institution - 0213, Mannheim, Not set
Local Institution - 0038, Nuernberg, Not set
Local Institution - 0040, Tuebingen, Not set
Local Institution - 0114, Weiden, Not set
Local Institution - 0039, Wuerzburg, Not set
Local Institution - 0102, Athens, Not set
Local Institution - 0103, Ioannina, Ípeiros
Local Institution - 0199, Kfar Saba, Not set
Local Institution - 0198, Ramat Gan, Not set
Local Institution - 0108, Arezzo, Not set
Local Institution - 0197, Faenza, Not set
Local Institution - 0111, Forlì, Not set
Local Institution - 0109, Grosseto, Not set
Local Institution - 0107, Milano, Not set
Local Institution - 0110, Napoli, Not set
Local Institution - 0136, Hirosaki, Aomori
Local Institution - 0135, Chiba-shi, Chiba
Local Institution - 0147, Matsuyama-shi, Ehime
Local Institution - 0140, Fukuoka-shi, Fukuoka
Local Institution - 0146, Sapporo-city, Hokkaido
Local Institution - 0150, Tsukuba-shi, Ibaraki
Local Institution - 0214, Morioka-shi, Iwate
Local Institution - 0137, Kita-Gun, Kagawa
Local Institution - 0141, Niigata-shi, Niigata
Local Institution - 0143, Okayama-shi, Okayama
Local Institution - 0144, Osaka-shi, Osaka
Local Institution - 0139, Osakasayama, Osaka
Local Institution - 0145, Takatsuki-shi, Osaka
Local Institution - 0201, Hamamatasu, Shizuoka
Local Institution - 0149, Adachi-ku, Tokyo
Local Institution - 0148, Bunkyo-ku, Tokyo
Local Institution - 0142, Bunkyo-ku, Tokyo
Local Institution - 0138, Shinjuku-Ku, Tokyo
Local Institution - 0215, Wakayama-shi, Wakayama
Local Institution - 0200, Ube City, Yamaguchi
Local Institution - 0125, Goyang-si, Gyeonggido
Local Institution - 0126, Seongnam-si, Not set
Local Institution - 0124, Seoul, Not set
Local Institution - 0151, Seoul, Not set
Local Institution - 0128, Seoul, Not set
Local Institution - 0127, Seoul, Not set
Local Institution - 0129, Ciudad de Mexico, Distrito Federal
Local Institution - 0154, Mexico City, Distrito Federal
Local Institution - 0130, Tlalpan, Distrito Federal
Local Institution - 0131, Monterrey, Nuevo Leon
Local Institution - 0022, Amsterdam, Noord-Holland
Local Institution - 0055, Enschede, Not set
Local Institution - 0024, Groningen, Not set
Local Institution - 0026, Leeuwarden, Not set
Local Institution - 0074, Bergen, Not set
Local Institution - 0081, Lorenskog, Not set
Local Institution - 0030, Lima, Not set
Local Institution - 0031, Lima, Not set
Local Institution - 0189, Bydgoszcz, Not set
Local Institution - 0205, Koszalin, Not set
Local Institution - 0202, Warszawa, Not set
Local Institution - 0191, Cluj-Napoca, Cluj
Local Institution - 0187, Craiova, Dolj
Local Institution, Moscow, Not set
Local Institution - 0192, Singapore, Central Singapore
Local Institution - 0070, A Coruna, Not set
Local Institution - 0068, Barcelona, Not set
Local Institution - 0065, Madrid, Not set
Local Institution - 0066, Madrid, Not set
Local Institution - 0209, Santander, Not set
Local Institution - 0067, Sevilla, Not set
Local Institution - 0069, Valencia, Not set
Local Institution - 0075, Jonkoping, Not set
Local Institution - 0059, Linkoping, Not set
Local Institution - 0058, Lund, Not set
Local Institution - 0061, Baden, Aargau
Local Institution - 0042, Chur, Not set
Local Institution - 0156, Kaohsiung, Not set
Local Institution - 0159, Taichung, Not set
Local Institution - 0158, Taipei, Not set
Local Institution - 0155, Taipei, Not set
Local Institution - 0157, Taoyuan, Not set
Local Institution - 0194, Ankara, Not set
Local Institution - 0204, Istanbul, Not set
Local Institution - 0193, Izmir, Not set
Conditions: Urothelial Cancer
Study of Sacituzumab Govitecan Combinations in First-line Treatment of Participants With Advanced or Metastatic Non-Small-Cell Lung Cancer (NSCLC)
Active Not Recruiting
The goal of this clinical study is to learn more about the study drug, sacituzumab govitecan-hziy (SG), and its dosing in combination with pembrolizumab or pembrolizumab and a platinum agent (carboplatin or cisplatin), in participants with advanced or metastatic (cancer that has spread) non-small-cell lung cancer (NSCLC).
The goal of this clinical study is to learn more about the study drug, sacituzumab govitecan-hziy (SG), and its dosing in combination with pembrolizumab or pembrolizumab and a platinum agent (carboplatin or cisplatin), in participants with advanced or metastatic (cancer that has spread) non-small-cell lung cancer (NSCLC). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/18/2024
Locations: Alaska Oncology and Hematology, LLC., Anchorage, Alaska +100 locations
Alaska Oncology and Hematology, LLC., Anchorage, Alaska
Beverly Hills Cancer Center, Beverly Hills, California
USC/Norris Comprehensive Cancer Center, Los Angeles, California
UCLA Hematology/Oncology - Santa Monica, Los Angeles, California
UC Irvine Health, Orange, California
Stanford Cancer Institute, Stanford, California
University of Colorado Hospital - Anschutz Cancer Pavilion (ACP), Aurora, Colorado
Georgetown University Medical Center, Washington, District of Columbia
Moffitt Cancer Center, Tampa, Florida
Northside Hospital Central Research Department, Atlanta, Georgia
Northwestern Memorial Hospital, Chicago, Illinois
Rush University Medical Center, Chicago, Illinois
Orchard Healthcare Research Inc., Skokie, Illinois
Kansas City Veterans Affairs Medical Center, Westwood, Kansas
Kansas City VA Medical Center, Kansas City, Missouri
Weill Cornell Medical/New York-Presbyterian Hospital, New York, New York
Great Lakes Cancer Care, Williamsville, New York
Wake Forest Baptist Health - High Point Medical Center, High Point, North Carolina
FirstHealth Outpatient Cancer Center, Pinehurst, North Carolina
University Hospital Cleveland Medical Center, Cleveland, Ohio
OSU Brain & Spine Hospital, Columbus, Ohio
Siouxland Regional Cancer Center dba June E. Nylen Cancer Center, North Sioux City, South Dakota
Southern Highlands Cancer Centre, Bowral, New South Wales
Saint Vincents Hospital Sydney, Darlinghurst, New South Wales
St George Private Hospital, Kogarah, New South Wales
Pindara Private Hospital, Benowa, Queensland
Sunshine Coast University Private Hospital, Birtinya, Queensland
Flinders Medical Centre, Bedford Park, South Australia
Ashford Cancer Centre Research, Windsor Gardens, South Australia
Peninsula Health - Frankston Hospital, Frankston, Victoria
Western Health - Sunshine Hospital, Melbourne, Victoria
Joondalup Health Campus, Joondalup, Western Australia
CIUSSS Saguenay Lac St-Jean, Quebec, Not set
McGill University Health Centre, Quebec, Not set
APHP - Hôpital Ambroise Paré, Boulogne-Billancourt, Not set
CHRU de Brest - Hopital Morvan, Brest, Not set
Centre Francois Baclesse, Caen, Not set
CHU de CAEN, Caen, Not set
Centre Jean Perrin - 58 rue Montalembert, Clermont-Ferrand, Not set
Centre Georges-François Leclerc, Dijon, Not set
Clinique Victor Hugo, Le Mans, Not set
Institut Curie, Paris, Not set
CHU de Bordeaux Hopital Haut leveque, Pessac, Not set
Hospices Civils de Lyon, Centre Hospitalier Lyon-Sud, Pierre Benite, Not set
Institut de Cancérologie de l'Ouest, Saint Herblain, Not set
Evangelische Lungenklinik Berlin Krakenhausbetriebs GmBH, Berlin, Not set
Klinikum Chemnitz gGmbH, Chemnitz, Not set
Universitatsklinikum Koln, Klinik I fur Innere Medizin, Cologne, Not set
Klinikum Esslingen GmbH, Klinik fur Kardiologie, Angiologie und Pneumologie, Esslingen, Not set
Universitatsklinikum Frankfurt, Frankfurt, Not set
Asklepios Fachkliniken Munchen-Gauting, Zentrum fur Pneumologie und Thoraxchirugie, Gauting, Not set
LungenClinic Grosshansdorf, Grosshansdorf, Not set
Martha-Maria Krankenhaus Halle Dölau gGmbH, Halle, Not set
LKI Lungenfachklinik Immenhausen, Immenhausen, Not set
Department of Clinical Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, Not set
Queen Elizabeth Hospital, Hong Kong, Not set
Queen Mary Hospital, Hong Kong, Not set
Hong Kong United Oncology Center, Kowloon, Not set
ASST Spedali Civili di Brescia, Brescia, Not set
AOU Policlinico Vittorio Emanuele - POG Rodolico, Catania, Not set
Azienda Ospedaliero-Universitaria di Parma, Parma, Not set
IRCCS Istituti Fisioterapicic Ospitalieri - Istituto Nazionale Tumori Regina Elena, Rome, Not set
IRCCS Instituto Clinico Humanitas, Rozzano, Not set
Chungbuk National University Hospital, Cheongju-si, Not set
Gachon University Gil Medical Center, Inchon, Not set
Asan Medical Center, Seoul, Not set
Seoul Metropolitan Government - Seoul National University Boramae Medical Center, Seoul, Not set
Severance Hospital, Yonsei University Health System, Seoul, Not set
The Catholic University of Korea St. Vincent's Hospital, Suwon, Not set
Sultan Ismail Hospital, Johor Bahru, Not set
Hospital Raja Perempuan Zainab II, Kota Bharu, Not set
Hospital Kuala Lumpur, Kuala Lumpur, Not set
University Malaya Medical Centre, Kuala Lumpur, Not set
Hospital Tengku Ampuan Afzan, Kuantan, Not set
Sarawak General Hospital, Kuching, Not set
Institut Kanser Negara, Putrajaya, Not set
Complejo Hospitalario Universitario A Coruna. Hospital Teresa Herrera, A coruna, Not set
Hospital Universitari Germans Trias i Pujol, Badalona, Not set
Hospital Universitari Vall d'Hebrón, Barcelona, Not set
Hospital Clinic de Barcelona, Barcelona, Not set
Hospital Duran i Reynals, Barcelona, Not set
Hospital General Universitario Gregorio Maranon, Madrid, Not set
Hospital Universitario Puerta de Hierro de Majadahonda, Majadahonda, Not set
Clinica Universidad de Navarra - Pamplona, Pamplona, Not set
Hospital Regional Universitario de Malaga-Hospital Civil, Rincon de la Victoria, Not set
Complejo Hospitalario Universitario de Santiago de Compostela CHUS_Hospital Clinico Universitario, Santiago de Compostela, Not set
Hospital Universitario Virgen de Valme, Sevilla, Not set
Hospital Universitario Virgen Macarena, Sevilla, Not set
Hospital Universitari i Politecnic La Fe, Valencia, Not set
Changhua Christian Hospital, Changhua City, Not set
Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City, Not set
E-DA Hospital, Kaohsiung City, Not set
Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Not set
Chi Mei Hospital - Liouying, Liouying Dist., Not set
National Cheng Kung University Hospital, Tainan City, Not set
Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taipei City, Not set
National Taiwan University Hospital, Taipei City, Not set
Taipei Veterans General Hospital, Taipei, Not set
Chang Gung Memorial Hospital (CGMH), Taoyuan City, Not set
University Hospitals Birmingham NHS Foundation Trust, Birmingham, Not set
Guy's and St Thomas' NHS Foundation Trust, London, Not set
Conditions: Non-small Cell Lung Cancer
Maintenance Chemotherapy or Observation Following Induction Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Ependymoma
Active Not Recruiting
The primary aim of this randomized phase III trial was to study whether the addition of maintenance chemotherapy delivered after surgical resection and focal radiation would be better than surgery and focal radiation alone. The trial also studied if patients who received induction chemotherapy and then either achieved a complete response or went on to have a complete resection would also benefit from maintenance chemotherapy. Children ages 1-21 years with newly diagnosed intracranial ependymoma... Read More
The primary aim of this randomized phase III trial was to study whether the addition of maintenance chemotherapy delivered after surgical resection and focal radiation would be better than surgery and focal radiation alone. The trial also studied if patients who received induction chemotherapy and then either achieved a complete response or went on to have a complete resection would also benefit from maintenance chemotherapy. Children ages 1-21 years with newly diagnosed intracranial ependymoma were included. There were 2 arms that were not randomized. One arm studied patients with Grade II tumors located in the supratentorial compartment that were completely resected. One arm studied patients with residual tumor and those patients all received maintenance chemotherapy after focal radiation. Chemotherapy drugs, such as vincristine sulfate, carboplatin, cyclophosphamide, etoposide, and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving more than one drug (combination chemotherapy) may kill more tumor cells. Radiation therapy uses high-energy x-rays to kill tumor cells. Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. Giving chemotherapy in combination with radiation therapy may kill more tumor cells and allow doctors to save the part of the body where the cancer started. Read Less
Gender:
ALL
Ages:
Between 12 months and 21 years
Trial Updated:
10/16/2024
Locations: Children's Hospital of Alabama, Birmingham, Alabama +208 locations
Children's Hospital of Alabama, Birmingham, Alabama
University of Alabama at Birmingham Cancer Center, Birmingham, Alabama
Banner Children's at Desert, Mesa, Arizona
Phoenix Childrens Hospital, Phoenix, Arizona
Banner University Medical Center - Tucson, Tucson, Arizona
Arkansas Children's Hospital, Little Rock, Arkansas
University of Arkansas for Medical Sciences, Little Rock, Arkansas
Kaiser Permanente Downey Medical Center, Downey, California
City of Hope Comprehensive Cancer Center, Duarte, California
Loma Linda University Medical Center, Loma Linda, California
Miller Children's and Women's Hospital Long Beach, Long Beach, California
Children's Hospital Los Angeles, Los Angeles, California
Cedars Sinai Medical Center, Los Angeles, California
Valley Children's Hospital, Madera, California
UCSF Benioff Children's Hospital Oakland, Oakland, California
Kaiser Permanente-Oakland, Oakland, California
Children's Hospital of Orange County, Orange, California
Lucile Packard Children's Hospital Stanford University, Palo Alto, California
Sutter Medical Center Sacramento, Sacramento, California
University of California Davis Comprehensive Cancer Center, Sacramento, California
Rady Children's Hospital - San Diego, San Diego, California
UCSF Medical Center-Parnassus, San Francisco, California
UCSF Medical Center-Mission Bay, San Francisco, California
Children's Hospital Colorado, Aurora, Colorado
Connecticut Children's Medical Center, Hartford, Connecticut
Yale University, New Haven, Connecticut
Alfred I duPont Hospital for Children, Wilmington, Delaware
MedStar Georgetown University Hospital, Washington, District of Columbia
Children's National Medical Center, Washington, District of Columbia
Broward Health Medical Center, Fort Lauderdale, Florida
Lee Memorial Health System, Fort Myers, Florida
Golisano Children's Hospital of Southwest Florida, Fort Myers, Florida
University of Florida Health Science Center - Gainesville, Gainesville, Florida
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood, Florida
Nemours Children's Clinic-Jacksonville, Jacksonville, Florida
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida
Nicklaus Children's Hospital, Miami, Florida
AdventHealth Orlando, Orlando, Florida
Arnold Palmer Hospital for Children, Orlando, Florida
Nemours Children's Clinic - Orlando, Orlando, Florida
Orlando Health Cancer Institute, Orlando, Florida
Nemours Children's Hospital, Orlando, Florida
Nemours Children's Clinic - Pensacola, Pensacola, Florida
Johns Hopkins All Children's Hospital, Saint Petersburg, Florida
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa, Florida
Saint Mary's Hospital, West Palm Beach, Florida
Children's Healthcare of Atlanta - Egleston, Atlanta, Georgia
Augusta University Medical Center, Augusta, Georgia
Memorial Health University Medical Center, Savannah, Georgia
Kapiolani Medical Center for Women and Children, Honolulu, Hawaii
Saint Luke's Cancer Institute - Boise, Boise, Idaho
Lurie Children's Hospital-Chicago, Chicago, Illinois
University of Illinois, Chicago, Illinois
University of Chicago Comprehensive Cancer Center, Chicago, Illinois
Loyola University Medical Center, Maywood, Illinois
Advocate Children's Hospital-Oak Lawn, Oak Lawn, Illinois
Saint Jude Midwest Affiliate, Peoria, Illinois
Southern Illinois University School of Medicine, Springfield, Illinois
Riley Hospital for Children, Indianapolis, Indiana
Ascension Saint Vincent Indianapolis Hospital, Indianapolis, Indiana
Blank Children's Hospital, Des Moines, Iowa
University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa
University of Kentucky/Markey Cancer Center, Lexington, Kentucky
Norton Children's Hospital, Louisville, Kentucky
Tulane University Health Sciences Center, New Orleans, Louisiana
Children's Hospital New Orleans, New Orleans, Louisiana
Ochsner Medical Center Jefferson, New Orleans, Louisiana
Eastern Maine Medical Center, Bangor, Maine
Maine Children's Cancer Program, Scarborough, Maine
University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland
Walter Reed National Military Medical Center, Bethesda, Maryland
Tufts Children's Hospital, Boston, Massachusetts
Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Dana-Farber Cancer Institute, Boston, Massachusetts
Baystate Medical Center, Springfield, Massachusetts
C S Mott Children's Hospital, Ann Arbor, Michigan
Wayne State University/Karmanos Cancer Institute, Detroit, Michigan
Ascension Saint John Hospital, Detroit, Michigan
Michigan State University Clinical Center, East Lansing, Michigan
Hurley Medical Center, Flint, Michigan
Helen DeVos Children's Hospital at Spectrum Health, Grand Rapids, Michigan
Bronson Methodist Hospital, Kalamazoo, Michigan
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis, Minnesota
University of Minnesota/Masonic Cancer Center, Minneapolis, Minnesota
Mayo Clinic in Rochester, Rochester, Minnesota
University of Mississippi Medical Center, Jackson, Mississippi
Columbia Regional, Columbia, Missouri
Children's Mercy Hospitals and Clinics, Kansas City, Missouri
Cardinal Glennon Children's Medical Center, Saint Louis, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Mercy Hospital Saint Louis, Saint Louis, Missouri
Children's Hospital and Medical Center of Omaha, Omaha, Nebraska
University of Nebraska Medical Center, Omaha, Nebraska
University Medical Center of Southern Nevada, Las Vegas, Nevada
Sunrise Hospital and Medical Center, Las Vegas, Nevada
Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas, Nevada
Summerlin Hospital Medical Center, Las Vegas, Nevada
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire
Hackensack University Medical Center, Hackensack, New Jersey
Saint Barnabas Medical Center, Livingston, New Jersey
Morristown Medical Center, Morristown, New Jersey
Saint Peter's University Hospital, New Brunswick, New Jersey
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick, New Jersey
Newark Beth Israel Medical Center, Newark, New Jersey
Saint Joseph's Regional Medical Center, Paterson, New Jersey
Overlook Hospital, Summit, New Jersey
University of New Mexico Cancer Center, Albuquerque, New Mexico
Albany Medical Center, Albany, New York
Montefiore Medical Center - Moses Campus, Bronx, New York
Roswell Park Cancer Institute, Buffalo, New York
NYU Winthrop Hospital, Mineola, New York
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York
Mount Sinai Hospital, New York, New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York
Memorial Sloan Kettering Cancer Center, New York, New York
University of Rochester, Rochester, New York
State University of New York Upstate Medical University, Syracuse, New York
New York Medical College, Valhalla, New York
UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina
Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina
Novant Health Presbyterian Medical Center, Charlotte, North Carolina
Wake Forest University Health Sciences, Winston-Salem, North Carolina
Sanford Broadway Medical Center, Fargo, North Dakota
Children's Hospital Medical Center of Akron, Akron, Ohio
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Rainbow Babies and Childrens Hospital, Cleveland, Ohio
Cleveland Clinic Foundation, Cleveland, Ohio
Nationwide Children's Hospital, Columbus, Ohio
Dayton Children's Hospital, Dayton, Ohio
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo, Ohio
Mercy Children's Hospital, Toledo, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Legacy Emanuel Children's Hospital, Portland, Oregon
Lehigh Valley Hospital-Cedar Crest, Allentown, Pennsylvania
Lehigh Valley Hospital - Muhlenberg, Bethlehem, Pennsylvania
Geisinger Medical Center, Danville, Pennsylvania
Penn State Children's Hospital, Hershey, Pennsylvania
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Saint Christopher's Hospital for Children, Philadelphia, Pennsylvania
Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
Rhode Island Hospital, Providence, Rhode Island
Medical University of South Carolina, Charleston, South Carolina
Prisma Health Richland Hospital, Columbia, South Carolina
BI-LO Charities Children's Cancer Center, Greenville, South Carolina
Greenville Cancer Treatment Center, Greenville, South Carolina
Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota
T C Thompson Children's Hospital, Chattanooga, Tennessee
East Tennessee Childrens Hospital, Knoxville, Tennessee
Saint Jude Children's Research Hospital, Memphis, Tennessee
The Children's Hospital at TriStar Centennial, Nashville, Tennessee
Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee
Dell Children's Medical Center of Central Texas, Austin, Texas
Driscoll Children's Hospital, Corpus Christi, Texas
Medical City Dallas Hospital, Dallas, Texas
Cook Children's Medical Center, Fort Worth, Texas
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas
Covenant Children's Hospital, Lubbock, Texas
UMC Cancer Center / UMC Health System, Lubbock, Texas
Children's Hospital of San Antonio, San Antonio, Texas
Methodist Children's Hospital of South Texas, San Antonio, Texas
University of Texas Health Science Center at San Antonio, San Antonio, Texas
Scott and White Memorial Hospital, Temple, Texas
Primary Children's Hospital, Salt Lake City, Utah
University of Vermont and State Agricultural College, Burlington, Vermont
Inova Fairfax Hospital, Falls Church, Virginia
Children's Hospital of The King's Daughters, Norfolk, Virginia
Naval Medical Center - Portsmouth, Portsmouth, Virginia
Virginia Commonwealth University/Massey Cancer Center, Richmond, Virginia
Carilion Children's, Roanoke, Virginia
Seattle Children's Hospital, Seattle, Washington
Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington
Mary Bridge Children's Hospital and Health Center, Tacoma, Washington
Madigan Army Medical Center, Tacoma, Washington
West Virginia University Charleston Division, Charleston, West Virginia
West Virginia University Healthcare, Morgantown, West Virginia
Saint Vincent Hospital Cancer Center Green Bay, Green Bay, Wisconsin
University of Wisconsin Carbone Cancer Center, Madison, Wisconsin
Marshfield Medical Center-Marshfield, Marshfield, Wisconsin
Children's Hospital of Wisconsin, Milwaukee, Wisconsin
John Hunter Children's Hospital, Hunter Regional Mail Centre, New South Wales
Sydney Children's Hospital, Randwick, New South Wales
The Children's Hospital at Westmead, Westmead, New South Wales
Royal Brisbane and Women's Hospital, Herston, Queensland
Royal Children's Hospital-Brisbane, Herston, Queensland
Queensland Children's Hospital, South Brisbane, Queensland
Women's and Children's Hospital-Adelaide, North Adelaide, South Australia
Monash Medical Center-Clayton Campus, Clayton, Victoria
Royal Children's Hospital, Parkville, Victoria
Princess Margaret Hospital for Children, Perth, Western Australia
Perth Children's Hospital, Perth, Western Australia
Alberta Children's Hospital, Calgary, Alberta
University of Alberta Hospital, Edmonton, Alberta
British Columbia Children's Hospital, Vancouver, British Columbia
CancerCare Manitoba, Winnipeg, Manitoba
Janeway Child Health Centre, Saint John's, Newfoundland and Labrador
IWK Health Centre, Halifax, Nova Scotia
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton, Ontario
Kingston Health Sciences Centre, Kingston, Ontario
Children's Hospital, London, Ontario
Children's Hospital of Eastern Ontario, Ottawa, Ontario
Hospital for Sick Children, Toronto, Ontario
The Montreal Children's Hospital of the MUHC, Montreal, Quebec
Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec
Saskatoon Cancer Centre, Saskatoon, Saskatchewan
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Quebec, Not set
Starship Children's Hospital, Grafton, Auckland
Christchurch Hospital, Christchurch, Not set
Conditions: Anaplastic Ependymoma, Brain Ependymoma, Cellular Ependymoma, Clear Cell Ependymoma, Ependymoma, Papillary Ependymoma
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