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Cyclophosphamide Treatment Options in Canada
A collection of 300 research studies where Cyclophosphamide is the interventional treatment. These studies are located in the Canada . Cyclophosphamide is used for conditions such as Breast Cancer, Lymphoma and Leukemia.
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Safety and Efficacy of ALLO-501A Anti-CD19 Allogeneic CAR T Cells in Adults with Relapsed/Refractory Large B Cell Lymphoma, Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma (ALPHA2)
Active Not Recruiting
This is a single-arm, open label, multicenter Phase 1/2 study evaluating ALLO-501A in adult subjects with R/R LBCL and CLL/SLL. The purpose of the ALPHA2 study is to assess the safety, efficacy, and cell kinetics of ALLO-501A in adults with relapsed or refractory large B-cell lymphoma and assess the safety of ALLO-501A in adults with relapsed or refractory chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) after a lymphodepletion regimen comprising fludarabine, cyclophosphamide, a... Read More
This is a single-arm, open label, multicenter Phase 1/2 study evaluating ALLO-501A in adult subjects with R/R LBCL and CLL/SLL. The purpose of the ALPHA2 study is to assess the safety, efficacy, and cell kinetics of ALLO-501A in adults with relapsed or refractory large B-cell lymphoma and assess the safety of ALLO-501A in adults with relapsed or refractory chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) after a lymphodepletion regimen comprising fludarabine, cyclophosphamide, and ALLO-647. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/22/2025
Locations: Banner MD Anderson Cancer Center, Gilbert, Arizona +22 locations
Banner MD Anderson Cancer Center, Gilbert, Arizona
Mayo Clinic Hospital, Phoenix, Arizona
City of Hope, Duarte, California
UCLA Medical Center, Los Angeles, California
Stanford Cancer Institute, Palo Alto, California
Colorado Blood Cancer Institute, Denver, Colorado
University of Miami, Miami, Florida
Advent Health, Orlando, Florida
Moffitt Cancer Center, Tampa, Florida
Northside Hospital - Atlanta, Atlanta, Georgia
Augusta University, Augusta, Georgia
Norton Cancer Institute, Louisville, Kentucky
Allegheny General Hospital, Pittsburgh, Pennsylvania
Vanderbilt Ingram Cancer Center, Nashville, Tennessee
St. David's South Austin Medical Center, Austin, Texas
Texas Oncology, Dallas, Texas
MD Anderson Cancer Center - University of Texas, Houston, Texas
Medical College of Wisconsin, Milwaukee, Wisconsin
Princess Alexandra Hospital, Woolloongabba, Queensland
Monash Medical Centre, Clayton, Victoria
St. Vincent's Hospital Melbourne, Fitzroy, Victoria
QEII Health Sciences Centre-VG Site, Halifax, Nova Scotia
CHU de Québec -Université Laval; Hôpital de l'Enfant-Jésus, Québec, Quebec
Conditions: Relapsed or Refractory Large B Cell Lymphoma, Relapsed or Refractory Chronic Lymphocytic Leukemia, Relapsed or Refractory Small Lymphocytic Lymphoma
A Study to Evaluate Change in Disease Activity of Subcutaneous (SC) Epcoritamab Combined With Intravenous and Oral Rituximab, Cyclophosphamide, Doxorubicin Hydrochloride, Vincristine, and Prednisone (R-CHOP) or R-CHOP in Adult Participants With Newly Diagnosed Diffuse Large B-Cell Lymphoma (DLBCL)
Active Not Recruiting
B-cell Lymphoma is an aggressive and rare cancer of a type of immune cells (a white blood cell responsible for fighting infections). The purpose of this study is to assess the change in disease activity of epcoritamab when combined with intravenous and oral rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine, and prednisone (R-CHOP) or R-CHOP in adult participants globally with diffuse large b-cell lymphoma (DLBCL). Change in disease activity will be assessed.
Epcoritamab is an... Read More
B-cell Lymphoma is an aggressive and rare cancer of a type of immune cells (a white blood cell responsible for fighting infections). The purpose of this study is to assess the change in disease activity of epcoritamab when combined with intravenous and oral rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine, and prednisone (R-CHOP) or R-CHOP in adult participants globally with diffuse large b-cell lymphoma (DLBCL). Change in disease activity will be assessed.
Epcoritamab is an investigational drug being developed for the treatment of DLBCL. Study doctors put the participants in groups called treatment arms. Participants will receive epcoritamab combined with R-CHOP, followed by epcoritamab or R-CHOP followed by rituximab will be explored. Approximately 900 adult participants with with newly diagnosed DLBCL will be enrolled in the study in approximately 315 sites in globally.
In the Arm 1, participants will receive subcutaneous epcoritamab combined with intravenous and oral R-CHOP followed by subcutaneous epcoritamab in 21-day cycles. In the Arm 2, participants will receive intravenous and oral R-CHOP followed by intravenous rituximab in 21-day cycles.
There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at an approved institution (hospital or clinic). The effect of the treatment will be frequently checked by medical assessments, blood tests, questionnaires and side effects. Read Less
Gender:
ALL
Ages:
Between 18 years and 79 years
Trial Updated:
01/22/2025
Locations: University of Arizona Cancer Center - North Campus /ID# 227463, Tucson, Arizona +330 locations
University of Arizona Cancer Center - North Campus /ID# 227463, Tucson, Arizona
Yuma Regional Medical Center /ID# 261527, Yuma, Arizona
University of Arkansas for Medical Sciences /ID# 225703, Little Rock, Arkansas
CBCC Global Research, Inc. /ID# 262037, Bakersfield, California
Alta Bates Summit Medical Center for Research /ID# 229427, Berkeley, California
Orange Coast Memorial Medical Center /ID# 229632, Fountain Valley, California
Providence - St. Jude Medical Center /ID# 262042, Fullerton, California
Saddleback Memorial Medical Center /ID# 229631, Laguna Hills, California
Long Beach Memorial Medical Ct /ID# 228996, Long Beach, California
Cancer and Blood Speciality Clinic - Los Alamitos /ID# 262032, Los Alamitos, California
University of Southern California /ID# 225443, Los Angeles, California
University of California, Los Angeles /ID# 226887, Los Angeles, California
Kaiser Permanente, Waterpark III Institute for Health Research /ID# 228618, Aurora, Colorado
Cancer Specialists of North Florida /ID# 226826, Jacksonville, Florida
Ocala Oncology Florida Cancer Affiliates - Main /ID# 262785, Ocala, Florida
Orlando Health Cancer Institute /ID# 232626, Orlando, Florida
Straub Medical Center /ID# 229464, Honolulu, Hawaii
University of Illinois at Chicago /ID# 226889, Chicago, Illinois
Southern IL Univ School of Med /ID# 228999, Springfield, Illinois
Springfield Clinic Main Campus /ID# 262584, Springfield, Illinois
Carle Cancer Institute /ID# 228338, Urbana, Illinois
Parkview Comprehensive Cancer Center /ID# 227026, Fort Wayne, Indiana
Goshen Center for Cancer Care /ID# 225534, Goshen, Indiana
University of Iowa Health Care /ID# 261945, Des Moines, Iowa
Cancer Center of Kansas /ID# 261983, Wichita, Kansas
Norton Cancer Institute - St. Matthews /ID# 225420, Louisville, Kentucky
University of Maryland, Baltimore /ID# 225421, Baltimore, Maryland
Johns Hopkins Hospital /ID# 225369, Baltimore, Maryland
American Oncology Partners of Maryland /ID# 226859, Bethesda, Maryland
UMass Memorial Medical Center /ID# 226939, Worcester, Massachusetts
University of Michigan Comprehensive Cancer Center Michigan Medicine /ID# 225462, Ann Arbor, Michigan
Trinity Health St. Joseph Mercy Ann Arbor /ID# 228206, Ypsilanti, Michigan
Metro Minnesota Community Oncology Research Consortium (MMCORC) /ID# 226680, Saint Louis Park, Minnesota
University of Mississippi Medical Center /ID# 228045, Jackson, Mississippi
Intermountain Health St. Vincent Regional Hospital - Cancer Centers of Montana /ID# 259014, Billings, Montana
NHO Revive Research Institute, LLC /ID# 261113, Lincoln, Nebraska
MDACC Cooper /ID# 260320, Camden, New Jersey
Titan Health Partners LLC, d/b/a Astera Cancer Care /ID# 226654, East Brunswick, New Jersey
Morristown Medical Center /ID# 239457, Morristown, New Jersey
University of New Mexico /ID# 227332, Albuquerque, New Mexico
Presbyterian Kaseman Hospital /ID# 262084, Albuquerque, New Mexico
Presbyterian Rust Medical Center /ID# 262068, Rio Rancho, New Mexico
New York Cancer and Blood Specialists- Eastchester, Bronx /ID# 265396, Bronx, New York
Roswell Park Cancer Institute /ID# 239127, Buffalo, New York
NYU Langone Hospital - Long Island /ID# 262412, Mineola, New York
New York Cancer and Blood Specialists- New Hyde Park /ID# 265392, New Hyde Park, New York
NYU Langone - Laura and Isaac Perlmutter Cancer Center /ID# 226141, New York, New York
New York Cancer and Blood Specialists- Manhattan /ID# 265391, New York, New York
Icahn School of Medicine at Mount Sinai /ID# 225370, New York, New York
Memorial Sloan Kettering Cancer Center-Koch Center /ID# 225379, New York, New York
New York Cancer and Blood Specialists /ID# 261114, Port Jefferson Station, New York
Novant Health Presbyterian Medical Center /ID# 227753, Charlotte, North Carolina
East Carolina University - Brody School of Medicine /ID# 225992, Greenville, North Carolina
Novant Health Forsyth Medical Center /ID# 228339, Winston-Salem, North Carolina
University of Cincinnati /ID# 225374, Cincinnati, Ohio
OhioHealth Arthur G.H. Bing, MD Cancer Center /ID# 260790, Columbus, Ohio
University of Oklahoma, Stephenson Cancer Center /ID# 225556, Oklahoma City, Oklahoma
Kaiser Permanente - Northwest /ID# 225488, Portland, Oregon
Houston Methodist Hospital /ID# 258957, Houston, Texas
Millennium Research & Clinical Development /ID# 228284, Kingwood, Texas
Joe Arrington Cancer Research /ID# 227217, Lubbock, Texas
Baylor Scott & White Medical Center- Temple /ID# 225935, Temple, Texas
Intermountain Medical Center /ID# 231184, Murray, Utah
University of Virginia Cancer Center - West Complex /ID# 225433, Charlottesville, Virginia
Virginia Commonwealth University Medical Center Main Hospital /ID# 225796, Richmond, Virginia
Vista Oncology - East Olympia /ID# 229375, Olympia, Washington
MultiCare Institute for Research & Innovation /ID# 225432, Tacoma, Washington
MultiCare Regional Cancer Center - Tacoma /ID# 265285, Tacoma, Washington
Liverpool Hospital /ID# 230072, Liverpool, New South Wales
Royal Adelaide Hospital /ID# 225683, Adelaide, South Australia
Monash Health - Monash Medical Centre /ID# 225680, Clayton, Victoria
Austin Health /ID# 225716, Heidelberg, Victoria
The Alfred Hospital /ID# 225999, Melbourne, Victoria
Hollywood Private Hospital /ID# 251837, Nedlands, Western Australia
Perth Blood Institute Ltd /ID# 225679, Nedlands, Western Australia
Royal Perth Hospital /ID# 226583, Perth, Western Australia
Universitaetsklinikum St. Poelten /ID# 234016, Sankt Poelten, Niederoesterreich
Medizinische Universitaet Wien /ID# 252095, Vienna, Wien
Klinik Ottakring /ID# 243941, Vienna, Wien
Landeskrankenhaus Salzburg-Universitaetsklinikum der PMU (LKH) /ID# 228360, Salzburg, Not set
Duplicate_ZAS Middelheim /ID# 225741, Antwerp, Antwerpen
ZAS Cadix /ID# 264327, Antwerp, Antwerpen
Cliniques Universitaires UCL Saint-Luc /ID# 225737, Woluwe-Saint-Lambert, Bruxelles-Capitale
Hospital La Louviere Site Jolimont - Helora /ID# 225738, La Louvière, Hainaut
CHU de Liège /ID# 225952, Liège, Liege
Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant /ID# 225742, Yvoir, Namur
UZ Gent /ID# 250031, Gent, Oost-Vlaanderen
Vitaz /Id# 226153, Sint-Niklaas, Oost-Vlaanderen
Universitair Ziekenhuis Leuven /ID# 225951, Leuven, Vlaams-Brabant
AZ-Delta /ID# 225736, Roeselare, West-Vlaanderen
Institut Jules Bordet /ID# 225954, Anderlecht, Not set
AZ Sint-Jan Brugge /ID# 225735, Brugge, Not set
Hospital de Clinicas da Universidade Federal do Parana /ID# 226027, Curitiba, Parana
Hospital Amaral Carvalho - Fundacao Doutor Amaral Carvalho /ID# 226065, Jaú, Sao Paulo
Fundacao Antonio Prudente - AC Camargo Cancer Center /ID# 226809, São Paulo, Sao Paulo
Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein /ID# 252832, São Paulo, Sao Paulo
Instituto Nacional de Cancer (INCA) /ID# 226026, Rio de Janeiro, Not set
Real e Benemérita Associação Portuguesa de Beneficência /ID# 226023, Sao Paulo, Not set
Hospital Alemao Oswaldo Cruz /ID# 252833, Sao Paulo, Not set
Instituto D'Or de Pesquisa e Ensino - Regional Sao Paulo /ID# 262394, Sao Paulo, Not set
Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao /ID# 226048, Sao Paulo, Not set
UMHAT Sveti Georgi /ID# 245780, Plovdiv, Not set
Acibadem City Clinic Tokuda University Hospital EAD /ID# 244616, Sofia, Not set
UMHAT Sveti Ivan Rilski /ID# 244615, Sofia, Not set
SHAT Hematologic Diseases /ID# 250102, Sofia, Not set
Arthur J.E. Child Comprehensive Cancer Centre Pharmacy /ID# 226077, Calgary, Alberta
BC Cancer - Vancouver /ID# 230573, Vancouver, British Columbia
William Osler Health System /ID# 250973, Brampton, Ontario
Juravinski Cancer Centre /ID# 226084, Hamilton, Ontario
Saskatoon Cancer Centre /ID# 226082, Saskatoon, Saskatchewan
The Fifth Medical Center of PLA General Hospital /ID# 230941, Beijing, Beijing
Beijing Cancer Hospital /ID# 229819, Beijing, Beijing
Peking University Third Hospital /ID# 230975, Beijing, Beijing
Fujian Provincial Cancer Hospital /ID# 238430, Fuzhou, Fujian
The First Affiliated Hospital of Xiamen University /ID# 238426, Xiamen, Fujian
Sun Yat-Sen University Cancer Center /ID# 238371, Guangzhou, Guangdong
Guangdong Provincial People's Hospital /ID# 230945, Guangzhou, Guangdong
Nanfang Hospital of Southern Medical University /ID# 238436, Guangzhou, Guangdong
Fourth Hospital of Hebei Medical University /ID# 238656, Shijiazhuang, Hebei
Harbin Medical University Cancer Hospital /Id# 241755, Harbin, Heilongjiang
Henan Cancer Hospital /ID# 230398, Zhengzhou, Henan
Union Hospital affiliated to Tongji Medical College of Huazhong University of Sc /ID# 234152, Wuhan, Hubei
Hubei Cancer Hospital /ID# 232256, Wuhan, Hubei
The First Affiliated Hospital of Soochow University /ID# 232569, Suzhou, Jiangsu
The Affiliated Hospital of Xuzhou Medical College /ID# 233174, Xuzhou, Jiangsu
The First Affiliated Hospital of Nanchang University /ID# 230399, Nanchang, Jiangxi
Jiangxi Provincial Cancer Hospital /ID# 233379, Nanchang, Jiangxi
The First Hospital of Jilin University /ID# 239618, Changchun, Jilin
The First Hospital of China Medical University /ID# 233201, Shenyang, Liaoning
Shandong Cancer Hospital /ID# 233200, Jinan, Shandong
Fudan University Cancer Hospital /ID# 251516, Shanghai, Shanghai
Shanxi Provincial Cancer Hospital /ID# 250745, Taiyuan, Shanxi
Tianjin Cancer Hospital /ID# 230974, Tianjin, Tianjin
Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sc /ID# 259904, Tianjin, Tianjin
The First Affiliated Hospital, Zhejiang University School of Medicine /ID# 230387, Hangzhou, Zhejiang
The second affiliated hospital of Zhejiang University school of medicine /ID# 231249, Hangzhou, Zhejiang
Zhejiang Cancer hospital /ID# 231388, Hangzhou, Zhejiang
Clinical Hospital Dubrava /ID# 251809, Zagreb, Grad Zagreb
Klinicka bolnica Merkur /ID# 252481, Zagreb, Grad Zagreb
Klinicki bolnicki centar Zagreb /ID# 250709, Zagreb, Grad Zagreb
Klinicki bolnicki centar Rijeka /ID# 251811, Rijeka, Primorsko-goranska Zupanija
Klinicki Bolnicki Centar (KBC) Split /ID# 250729, Split, Splitsko-dalmatinska Zupanija
Opca bolnica Dr. Josip Bencevic /ID# 251812, Slavonski Brod, Not set
Fakultní Nemocnice Brno - Jihlavská /ID# 225953, Brno, Brno-mesto
Fakultní nemocnice Hradec Králové - Sokolská /ID# 225955, Hradec Králové, Hradec Kralove
Fakultni Nemocnice Ostrava /ID# 225957, Ostrava, Ostrava-mesto
Duplicate_Fakultni Nemocnice v Motole /ID# 225958, Prague, Not set
Fakultni nemocnice Kralovske Vinohrady /ID# 225956, Praha, Not set
Vseobecna fakultni nemocnice v Praze /ID# 225396, Praha, Not set
Rigshospitalet /ID# 226576, Copenhagen Ø, Hovedstaden
Aarhus Universitetshospital - Skejby /ID# 226594, Aarhus, Midtjylland
Roskilde Sygehus /ID# 226597, Roskilde, Sjælland
Odense University Hospital /ID# 226593, Odense, Syddanmark
Sygehus Lillebalt, Vejle /ID# 226592, Vejle, Syddanmark
CHU de Nice - Hôpital Archet 1 /ID# 226127, Nice, Alpes-Maritimes
CHU Clermont-Ferrand /ID# 229283, Clermont, Auvergne-Rhone-Alpes
Institut Paoli-Calmettes /ID# 226557, Marseille, Bouches-du-Rhone
CHU de Rennes - PONTCHAILLOU /ID# 228207, Rennes, Bretagne
CHU Dijon /ID# 238345, Dijon, Cote-d Or
CHU Limoges - Dupuytren 1 /ID# 234235, Limoges CEDEX 1, Franche-Comte
CHU Montpellier - Hopital Saint Eloi /ID# 228191, Montpellier Cedex 5, Herault
Hopital Pitie Salpetriere /ID# 238343, Paris, Ile-de-France
CHU Grenoble - Hopital Michallon /ID# 226128, La Tronche, Isere
CHRU Nancy - Hopitaux de Brabois /ID# 226102, Vandoeuvre-les-Nancy, Meurthe-et-Moselle
CHRU Lille - Hopital Claude Huriez /ID# 226101, Lille, Nord
Hopitaux Universitaires Henri Mondor - Hopital Henri Mondor /ID# 226560, Creteil, Paris
CHU de Nantes, Hotel Dieu -HME /ID# 226125, Nantes, Pays-de-la-Loire
Centre Hospitalier de la Cote Basque /ID# 249143, Bayonne, Pyrenees-Atlantiques
HCL - Hopital Lyon Sud /ID# 227086, Pierre Benite CEDEX, Rhone
Centre Henri Becquerel /ID# 226103, Rouen, Seine-Maritime
CHU Amiens-Picardie Site Sud /ID# 238347, Amiens CEDEX 1, Somme
CHD Vendée- La Roche-sur-Yon - Les Oudairies /ID# 243899, La Roche Sur Yon, Vendee
CHU Poitiers - La miletrie /ID# 226578, Poitiers, Vienne
Chu Angers /Id# 245931, Angers, Not set
CHU de CAEN - Hopital de la Cote de Nacre /ID# 226582, Caen, Not set
Hôpital Saint-Louis /ID# 226126, Paris, Not set
Institut Curie - site CLCC René Huguenin /ID# 253519, Saint-cloud, Not set
General Hospital of Athens Laiko /ID# 225399, Athens, Attiki
Alexandra General Hospital /ID# 225402, Athens, Attiki
University General Hospital Attikon /ID# 225401, Athens, Attiki
General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 225416, Athens, Not set
University General Hospital of Ioannina /ID# 225400, Ioannina, Not set
General University Hospital of Thessaloniki AXEPA /ID# 225398, Thessaloniki, Not set
Theageneio Anticancer Hospital /ID# 225516, Thessaloniki, Not set
Gyor-Moson-Sopron Varmegyei Petz Aladar Egyetemi Oktato Korhaz /ID# 257189, Gyor, Gyor-Moson-Sopron
Debreceni Egyetem-Klinikai Kozpont /ID# 226821, Debrecen, Hajdu-Bihar
Somogy Varmegyei Kaposi Mor Oktato Korhaz /ID# 245938, Kaposvár, Somogy
Tolna Varmegyei Balassa Janos Korhaz /ID# 250063, Szekszard, Tolna
Vas Varmegyei Markusovszky Egyetemi Oktatokorhaz /ID# 226846, Szombathely, Vas
Semmelweis Egyetem /ID# 227239, Budapest, Not set
Orszagos Onkologiai Intezet /ID# 227294, Budapest, Not set
Szegedi Tudományegyetem /ID# 226838, Szeged, Not set
Rambam Health Care Campus /ID# 225981, Haifa, H_efa
Meir Medical Center /ID# 225612, Kfar Saba, HaMerkaz
Assuta Tel Aviv Medical Center /ID# 226066, Tel Aviv, HaMerkaz
The Chaim Sheba Medical Center /ID# 225600, Ramat Gan, Tel-Aviv
Tel Aviv Sourasky Medical Center /ID# 225891, Tel Aviv, Tel-Aviv
Shaare Zedek Medical Center /ID# 259796, Jerusalem, Yerushalayim
Hadassah /ID# 225614, Jerusalem, Yerushalayim
Rabin Medical Center /ID# 225862, Petah Tikva, Not set
IRCCS AOU di Bologna - Policlinico Sant'Orsola-Malpighi /ID# 225551, Bologna, Emilia-Romagna
Fondazione di Religione e di Culto Casa Sollievo della Sofferenza /ID# 225554, San Giovanni Rotondo, Foggia
IRCCS Ospedale San Raffaele /ID# 225555, Milan, Milano
Istituto Europeo Di Oncologia /ID# 225545, Milan, Milano
Azienda Ospedaliera Universitaria Federico II /ID# 225543, Naples, Napoli
A.O.U. CITTA' DELLA SALUTE E DELLA SCIENZA DI TORINO - Ospedale Molinette /ID# 225775, Torino, Piemonte
Duplicate_Centro di Riferimento Oncologico /ID# 225553, Aviano, Pordenone
Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST - IRCCS /ID# 252192, Meldola, Reggio Emilia
Istituto di Candiolo Fondazione del Piemonte per l'Oncologia IRCCS /ID# 225751, Candiolo, Torino
Azienda Ospedaliero - Universitaria SS. Antonio e Biagio e Cesare Arrigo - Aless /ID# 225542, Alessandria, Not set
I.R.C.C.S Istituto Tumori Giovanni Paolo II /ID# 225548, Bari, Not set
Duplicate_ASST Spedali civili di Brescia /ID# 225549, Brescia, Not set
Azienda Ospedaliero Universitaria Maggiore della Carita di Novara /ID# 225773, Novara, Not set
Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello /ID# 225541, Palermo, Not set
Azienda Ospedaliero Universitaria Pisana /ID# 225575, Pisa, Not set
Ospedale Santa Maria Delle Croci /ID# 225571, Ravenna, Not set
NHO Nagoya Medical Center /ID# 230677, Nagoya-shi, Aichi
Aichi Cancer Center Hospital /ID# 226090, Nagoya-shi, Aichi
National Cancer Center Hospital East /ID# 250151, Kashiwa-shi, Chiba
Matsuyama Red Cross Hospital /ID# 251068, Matsuyama-shi, Ehime
National Hospital Organization Kyushu Cancer Center /ID# 251622, Fukuoka-shi, Fukuoka
Kyushu University Hospital /ID# 226091, Fukuoka-shi, Fukuoka
Fukushima Medical University Hospital /ID# 250869, Fukushima-shi, Fukushima
Duplicate_Hokkaido University Hospital /ID# 250149, Sapporo-shi, Hokkaido
Kobe City Medical Center General Hospital /ID# 250597, Kobe-shi, Hyogo
University of Tsukuba Hospital /ID# 251282, Tsukuba-shi, Ibaraki
Kanazawa University Hospital /ID# 251770, Kanazawa-shi, Ishikawa
Kagoshima University Hospital /ID# 250163, Kagoshima-shi, Kagoshima
Tokai University Hospital /ID# 251281, Isehara, Kanagawa
Tohoku University Hospital /ID# 250150, Sendai-shi, Miyagi
Okayama University Hospital /ID# 250161, Okayama-shi, Okayama
Kindai University Hospital /ID# 250160, Osakasayama-shi, Osaka
Osaka University Hospital /ID# 251283, Suita-shi, Osaka
National Cancer Center Hospital /ID# 226089, Chuo-ku, Tokyo
The Cancer Institute Hospital Of JFCR /ID# 230269, Koto-ku, Tokyo
Yamagata University Hospital /ID# 230003, Yamagata-shi, Yamagata
Inje University - Busan Paik Hospital /ID# 232262, Busan, Busan Gwang Yeogsi
Seoul National University Bundang Hospital /ID# 225763, Seongnam-si, Gyeonggido
Keimyung University Dongsan Hospital /ID# 232264, Daegu, Gyeongsangbugdo
Dong-A University Medical Center /ID# 228451, Busan, Gyeongsangnamdo
Jeonbuk National University Hospital /ID# 232263, Jeonju, Jeonrabugdo
Seoul National University Hospital /ID# 225760, Seoul, Seoul Teugbyeolsi
Asan Medical Center /ID# 225758, Seoul, Seoul Teugbyeolsi
Samsung Medical Center /ID# 225759, Seoul, Seoul Teugbyeolsi
The Catholic University of Korea, Seoul St. Marys Hospital /ID# 225761, Seoul, Seoul Teugbyeolsi
Ulsan University Hospital /ID# 226971, Ulsan, Ulsan Gwang Yeogsi
Flevo Ziekenhuis /ID# 229606, Almere, Flevoland
Medisch Centrum Leeuwarden /ID# 225605, Leeuwarden, Friesland
Gelre Ziekenhuizen /ID# 229762, Apeldoorn, Gelderland
Canisius-Wilhelmina Ziekenhuis /ID# 231291, Nijmegen, Gelderland
Maastricht Universitair Medisch Centrum /ID# 225607, Maastricht, Limburg
Amphia Ziekenhuis /ID# 229550, Breda, Noord-Brabant
Catharina Ziekenhuis /ID# 230465, Eindhoven, Noord-Brabant
Maxima Medisch Centrum /ID# 225603, Eindhoven, Noord-Brabant
Elisabeth Tweesteden Ziekenhuis /ID# 229773, Tilburg, Noord-Brabant
Noordwest Ziekenhuisgroep /ID# 230613, Alkmaar, Noord-Holland
Vrije Universiteit Medisch Centrum /ID# 225608, Amsterdam, Noord-Holland
Olvg /Id# 229761, Amsterdam, Noord-Holland
Spaarne Gasthuis, Haarlem Zuid /ID# 229621, Haarlem, Noord-Holland
Tergooi /ID# 229772, Hilversum, Noord-Holland
Dijklander Ziekenhuis /ID# 229900, Hoorn Nh, Noord-Holland
Zaans Medisch Centrum /ID# 230614, Zaandam, Noord-Holland
Medisch Spectrum Twente /ID# 225610, Enschede, Overijssel
Meander Medisch Centrum /ID# 229608, Amersfoort, Utrecht
St. Antonius Ziekenhuis /ID# 229901, Nieuwegein, Utrecht
Albert Schweitzer Ziekenhuis /ID# 229560, Dordrecht, Zuid-Holland
Leids Universitair Medisch Centrum /ID# 225606, Leiden, Zuid-Holland
Haaglanden Medisch Centrum /ID# 229686, Den Haag, Not set
Deventer Ziekenhuis /ID# 229937, Deventer, Not set
Universitair Medisch Centrum Groningen /ID# 225602, Groningen, Not set
Jeroen Bosch Ziekenhuis /ID# 229765, S Hertogenbosch, Not set
Diakonessenhuis /ID# 251793, Utrecht, Not set
North Shore Hospital /ID# 250992, Takapuna, Auckland
Christchurch Hospital /ID# 250993, Christchurch, Canterbury
Wojewodzki Szpital Specjalistyczny im. Janusza Korczaka /ID# 228723, Slupsk, Pomorskie
Swietokrzyskie Centrum Onkologii Samodzielny Publiczny Zaklad Opieki Zdrowotnej /ID# 225986, Kielce, Swietokrzyskie
Szpital Kliniczny MSWiA z Warminsko-Mazurskim Centrum Onkologii /ID# 225985, Olsztyn, Warminsko-mazurskie
ARS-MEDICAL Sp. z o.o. /ID# 225848, Pila, Wielkopolskie
Centrum Medyczne Pratia Poznan /ID# 227236, Skorzewo, Wielkopolskie
2CA-Braga, Hospital de Braga /ID# 249112, Braga, Not set
IPO Lisboa FG, EPE /ID# 249109, Lisboa, Not set
Unidade Local de Saude de Santa Maria, EPE /ID# 249111, Lisboa, Not set
IPO Porto FG, EPE /ID# 249110, Porto, Not set
Hospital Erasto Gaertner /ID# 262593, Curitiba, Not set
Hematology and Oncology Institute /ID# 230054, Manati, Not set
Pan American Center for Oncology Trials, LLC /ID# 230052, Rio Piedras, Not set
Narodny onkologicky ustav /ID# 238847, Bratislava, Bratislavsky Kraj
Univerzitna nemocnica Martin /ID# 240828, Martin, Zilinsky Kraj
Wits Clinical Research /ID# 227799, Johannesburg, Gauteng
Wits Clinical Research /ID# 227803, Johannesburg, Gauteng
Alberts Cellular Therapy /ID# 227798, Pretoria, Gauteng
University of Cape Town /ID# 227802, Cape Town, Western Cape
Haemalife Inc. /ID# 243391, Kuilsrivier, Western Cape
Instituto Catalan de Oncologia (ICO) Badalona /ID# 228063, Badalona, Barcelona
Institut Català d'Oncologia (ICO) - L'Hospitalet /ID# 227393, L'Hospitalet de Llobregat, Barcelona
Hospital Universitario Reina Sofia /ID# 225806, Córdoba, Cordoba
Hospital Clinico Universitario Virgen de la Arrixaca /ID# 255381, El Palmar, Murcia
Clinica Universidad de Navarra - Pamplona /ID# 225809, Pamplona, Navarra
Hospital Parc de Salut del Mar /ID# 225810, Barcelona, Not set
Hospital Universitario Vall d'Hebron /ID# 225811, Barcelona, Not set
Hospital Clinic de Barcelona /ID# 226651, Barcelona, Not set
Hospital Santa Creu i Sant Pau /ID# 225813, Barcelona, Not set
CLINICA UNIVERSIDAD DE NAVARRA-Madrid /ID# 228228, Madrid, Not set
Hospital Universitario Infanta Leonor /ID# 225816, Madrid, Not set
MD Anderson Madrid /ID# 225817, Madrid, Not set
Hospital Universitario Ramon y Cajal /ID# 241750, Madrid, Not set
Hospital Universitario Fundacion Jimenez Diaz /ID# 225804, Madrid, Not set
Hospital Universitario 12 de Octubre /ID# 225815, Madrid, Not set
Hospital Clinico Universitario de Valencia /ID# 225818, Valencia, Not set
Linkoping University Hospital /ID# 233521, Linkoping, Ostergotlands Lan
Skane University Hospital Lund /ID# 227285, Lund, Skane Lan
Karolinska University Hospital Solna /ID# 229284, Solna, Stockholms Lan
Sodra Alvsborgs sjukhus /ID# 228885, Boras, Vastra Gotalands Lan
Sahlgrenska Universitetssjukhuset /ID# 250089, Göteborg, Vastra Gotalands Lan
Kantonsspital Aarau AG /ID# 229112, Aarau, Aargau
Spital Thun /ID# 229499, Thun, Bern
KSW Kantonsspital Winterthur /ID# 241631, Winterthur, Zuerich
Kaohsiung Chang Gung Memorial Hospital /ID# 226670, Kaohsiung City, Kaohsiung
China Medical University Hospital /ID# 226188, Taichung, Not set
Taichung Veterans General Hospital /ID# 226674, Taichung, Not set
National Cheng Kung University Hospital /ID# 226671, Tainan, Not set
Anadolu Saglik Merkezi /ID# 225777, Dilovası, Kocaeli
Ankara Universitesi Fakultesi /ID# 227331, Ankara, Not set
Inonu University Medical Faculty /ID# 226572, Malatya, Not set
Ondokuz Mayis Universitesi /ID# 251247, Samsun, Not set
Karadeniz University /ID# 226573, Trabzon, Not set
Baskent Universitesi Adana Uyg. ve Arast. Merkezi Yuregir Baskent Hastanesi /ID# 225921, Yuregir, Not set
Hammersmith Hospital /ID# 242215, London, England
Norfolk and Norwich University Hospitals NHS Foundation Trust /ID# 226692, Norwich, Norfolk
University Hospitals Birmingham NHS Foundation Trust /ID# 229197, Birmingham, Not set
NHS Lothian /ID# 229055, Edinburgh, Not set
Conditions: Diffuse Large B-Cell Lymphoma
A Study of Glofitamab in Combination With Rituximab or Obinutuzumab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (CHOP), or Polatuzumab Vedotin Plus Rituximab, Cyclophosphamide, Doxorubicin, and Prednisone (CHP) in Participants With Non-Hodgkin Lymphomas or With DLBCL
Completed
This is a phase 1B, multi-center, dose-finding study of glofitamab administered in combination with obinutuzumab (Gazyva; \[G\]), rituximab (R) and standard doses of CHOP (G/R-CHOP or R-CHOP) in participants with r/r NHL and G/R CHOP or Pola-R-CHP in participants with untreated diffuse large B-cell lymphoma (DLBCL). Evaluating the safety, preliminary activity, pharmacokinetic (PK), and pharmacodynamic effects of this combination will be the main objectives of this study. The study is divided in... Read More
This is a phase 1B, multi-center, dose-finding study of glofitamab administered in combination with obinutuzumab (Gazyva; \[G\]), rituximab (R) and standard doses of CHOP (G/R-CHOP or R-CHOP) in participants with r/r NHL and G/R CHOP or Pola-R-CHP in participants with untreated diffuse large B-cell lymphoma (DLBCL). Evaluating the safety, preliminary activity, pharmacokinetic (PK), and pharmacodynamic effects of this combination will be the main objectives of this study. The study is divided in two parts:
* Part I: Dose finding in participants with r/r NHL; test use of G vs R in Cycle 1
* Part II: Dose Expansion. The maximum tolerated dose or optimal biological dose (MTD or OBD) will be further assessed in participants with untreated DLBCL (\>18 years of age with an age-adjusted International Prognostic Index (IPI) of 2-5). Glofitamab will be studied in combination with R-CHOP and Pola-R-CHP. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/15/2025
Locations: University of Alabama Medical Center, Birmingham, Alabama +21 locations
University of Alabama Medical Center, Birmingham, Alabama
Levine Cancer Institute, Charlotte, North Carolina
Fox Chase-Temple Cancer Center, Philadelphia, Pennsylvania
Peter Maccallum Cancer Centre, Melbourne, Victoria
Princess Margaret Cancer Center, Toronto, Ontario
Rigshospitalet, København Ø, Not set
Hopital Claude Huriez, Lille, Not set
Hopital Hotel Dieu Et Hme, Nantes, Not set
Centre Henri Becquerel, Rouen, Not set
Universitätsklinikum Erlangen, Translational Research Center (TRC), Medizin 5, Erlangen, Not set
Universitätsklinikum Freiburg, Freiburg, Not set
Universitätsklinikum Ulm, Ulm, Not set
Universitätsklinikum Würzburg, Wuerzburg, Not set
Istituto Nazionale Tumori Irccs Fondazione g. Pascale, Napoli, Campania
UO Ematologia, Ospedale S.Maria delle Croci, Ravenna, Emilia-Romagna
Asst Papa Giovanni Xxiii, Bergamo, Lombardia
Istituto Clinico Humanitas, Rozzano, Lombardia
Hospital Universitari Vall d'Hebron, Barcelona, Not set
Hospital Clínic i Provincial, Barcelona, Not set
START Madrid-FJD, Hospital Fundacion Jimenez Diaz, Madrid, Not set
University College London Hospitals NHS Foundation Trust, London, Not set
Nottingham University Hospitals NHS Trust - City Hospital, Nottingham, Not set
Conditions: B-Cell Lymphoma, Non-Hodgkin Lymphoma
Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors
Active Not Recruiting
A study to learn about safety and find out maximum tolerable dose of palbociclib given in combination with chemotherapy (temozolomide with irinotecan or topotecan with cyclophosphamide) in children, adolescents and young adults with recurrent or refractory solid tumors (phase 1). Neuroblastoma tumor specific cohort to further evaluate antitumor activity of palbociclib in combination with topotecan and cyclophosphamide in children, adolescents, and young adults with recurrent or refractory neurob... Read More
A study to learn about safety and find out maximum tolerable dose of palbociclib given in combination with chemotherapy (temozolomide with irinotecan or topotecan with cyclophosphamide) in children, adolescents and young adults with recurrent or refractory solid tumors (phase 1). Neuroblastoma tumor specific cohort to further evaluate antitumor activity of palbociclib in combination with topotecan and cyclophosphamide in children, adolescents, and young adults with recurrent or refractory neuroblastoma. Phase 2 to learn about the efficacy of palbociclib in combination with irinotecan and temozolomide when compared with irinotecan and temozolomide alone in the treatment of children, adolescents, and young adults with recurrent or refractory Ewing sarcoma (EWS). Read Less
Gender:
ALL
Ages:
Between 2 years and 20 years
Trial Updated:
01/13/2025
Locations: University of Alabama at Birmingham/Children's of Alabama, Birmingham, Alabama +100 locations
University of Alabama at Birmingham/Children's of Alabama, Birmingham, Alabama
Phoenix Children's Hospital, Phoenix, Arizona
MemorialCare Health System - Long Beach Medical Center, Long Beach, California
Children's Hospital Los Angeles, Los Angeles, California
Children's Hospital and Research Center at Oakland, Oakland, California
Children's Hospital of Orange County, Orange, California
Lucile Packard Children's Hospital, Palo Alto, California
UCSF Medical Center, San Francisco, California
University of California San Francisco,, San Francisco, California
Children's Hospital Colorado, Aurora, Colorado
Children's National Hospital, Washington, District of Columbia
UF Health Shands Hospital, Gainesville, Florida
University of Florida College of Medicine, Gainesville, Florida
Johns Hopkins All Children's Hospital, Saint Petersburg, Florida
Johns Hopkins All Children's Outpatient Care Center, Saint Petersburg, Florida
Johns Hopkins All Children's Hospital, Tampa, Florida
Children's Healthcare of Atlanta at Egleston, Atlanta, Georgia
Children's Healthcare of Atlanta at Scottish Rite, Atlanta, Georgia
Children's Healthcare of Atlanta, Medical Office Building, Atlanta, Georgia
Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois
Indiana University, Indianapolis, Indiana
Norton Children's Hospital, Louisville, Kentucky
Novak Center for Children's Health, Louisville, Kentucky
Johns Hopkins University, Baltimore, Maryland
University of Michigan Health System, Ann Arbor, Michigan
University of Minnesota Masonic Children's Hospital, Minneapolis, Minnesota
University of Minnesota Medical Center, Fairview, Minneapolis, Minnesota
University of Minnesota/Masonic Cancer Center, Minneapolis, Minnesota
University of Minnesota, Minneapolis, Minnesota
University of Mississippi Medical Center, Jackson, Mississippi
Children's Mercy Hospital, Kansas City, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Robert Wood Johnson University Hospital, New Brunswick, New Jersey
Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey
Montefiore Medical Center, Bronx, New York
John R. Oishei Childrens Hospital, Buffalo, New York
Roswell Park Cancer Institute, Buffalo, New York
Cohen Children's Medical Center, New Hyde Park, New York
Morgan Stanley Children's Hospital of New York-Presbyetrian Hospital, New York, New York
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
University Hospitals Cleveland Medical Center, Cleveland, Ohio
Nationwide Children's Hospital, Columbus, Ohio
Cincinnati Children's Liberty Campus, Liberty Township, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Oregon Health & Science University, Portland, Oregon
Penn State Children's Hospital and Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania
Buerger Center for Advanced Pediatric Care, Philadelphia, Pennsylvania
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania
Children's Blood and Cancer Center, Austin, Texas
Dell Children's Medical Center, Austin, Texas
Children's Medical Center Dallas, Dallas, Texas
Cook Children's Medical Center, Fort Worth, Texas
Cook Children's H/O Infusion Center, Grapevine, Texas
Texas Children's Hospital, Houston, Texas
Children's Medical Center Plano, Plano, Texas
Intermountain - Primary Children's Hospital, Salt Lake City, Utah
Primary Children's Hospital Outpatient Services, Salt Lake City, Utah
Children's Hospital of The King's Daughters, Norfolk, Virginia
Children's Hospital of Richmond at VCU, Richmond, Virginia
Seattle Children's Hospital, Seattle, Washington
Children's Wisconsin, Milwaukee, Wisconsin
Medical College of Wisconsin, Milwaukee, Wisconsin
Hospital Pequeno Principe / A ssociacao Hospitalar de Protecao a Infancia, Curitiba, Paraná
Hospital Pequeno Príncipe, Curitiba, Paraná
Hospital de Clinicas de Porto Alegre, Porto Alegre, RIO Grande DO SUL
Hospital de Clinicas de Porto Alegre, Porto Alegre, RIO Grande DO SUL
Fundação Pio XII - Hospital de Câncer de Barretos, Barretos, SÃO Paulo
Instituto Nacional de Câncer - INCA, Rio de Janeiro, Not set
Hospital Santa Marcelina, São Paulo, Not set
Alberta Children's Hospital, Calgary, Alberta
Stollery Children's Hospital, Edmonton, Alberta
The Hospital for Sick Children, Toronto, Ontario
CHU Sainte-Justine, Montreal, Quebec
Detska nemocnice FN Brno, Brno, Brno-město
Fakultni nemocnice v Motole, Praha, Praha 5
Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest, Bordeaux, Aquitaine
Centre Leon Berard, Lyon, Rhône-alpes
Centre Leon Berard, Lyon, Rhône-alpes
Gustave Roussy, Villejuif, Val-de-marne
Assistance Publique Hôpitaux de Marseille - Hôpital de la Timone, Marseille, Not set
Universitätsklinikum Essen, Essen, Nordrhein-westfalen
All India Institute of Medical Sciences, New Delhi, Delhi
Rajiv Gandhi Cancer Institute And Research Centre, New Delhi, Delhi
Artemis hospital, Gurugram, Haryana
National Cancer Center, Goyang-si, Kyǒnggi-do
Seoul National University Hospital, Seoul, Seoul-teukbyeolsi [seoul]
Asan Medical Center, Seoul, Seoul-teukbyeolsi [seoul]
Samsung Medical Center, Seoul, Seoul-teukbyeolsi [seoul]
Instytut Matki i Dziecka, Warsaw, Mazowieckie
Detska fakultna nemocnica s poliklinikou Banska Bystrica, Banska Bystrica, Not set
Narodny ustav detskych chorob, Bratislava, Not set
Hospital Universitari Vall d'Hebron, Barcelona, Barcelona [barcelona]
Hospital Infantil Universitario Niño Jesús, Madrid, Madrid, Comunidad DE
Sahlgrenska Universitetssjukhuset Östra, Gothenburg, Västra Götalands LÄN [se-14]
Ege Universitesi Hastanesi, İzmir, İ̇zmir
Hacettepe Universite Hastaneleri, Ankara, Not set
Royal Victoria Infirmary, Newcastle upon Tyne, England
Royal Hospital for Children, Glasgow, Scotland
Leeds General Infirmary, Leeds, Not set
University College London Hospital, NHS Foundation Trust, London, Not set
Conditions: Solid Tumors, Ewing Sarcoma, Rhabdoid Tumor, Rhabdomyosarcoma, Neuroblastoma, Medulloblastoma, Diffuse Intrinsic Pontine Glioma
Study of Pembrolizumab (MK-3475) Plus Chemotherapy vs Placebo Plus Chemotherapy as Neoadjuvant Therapy and Pembrolizumab vs Placebo as Adjuvant Therapy in Participants With Triple Negative Breast Cancer (TNBC) (MK-3475-522/KEYNOTE-522)
Active Not Recruiting
The purpose of this study is to evaluate the efficacy and safety of pembrolizumab (MK-3475) plus chemotherapy vs placebo plus chemotherapy as neoadjuvant therapy and pembrolizumab vs placebo as adjuvant therapy in participants who have triple negative breast cancer (TNBC).
After a screening phase of approximately 28 days, each participant will receive neoadjuvant study treatment (Pembrolizumab + Chemotherapy OR Placebo + Chemotherapy) based on the randomization schedule for approximately 24 wee... Read More
The purpose of this study is to evaluate the efficacy and safety of pembrolizumab (MK-3475) plus chemotherapy vs placebo plus chemotherapy as neoadjuvant therapy and pembrolizumab vs placebo as adjuvant therapy in participants who have triple negative breast cancer (TNBC).
After a screening phase of approximately 28 days, each participant will receive neoadjuvant study treatment (Pembrolizumab + Chemotherapy OR Placebo + Chemotherapy) based on the randomization schedule for approximately 24 weeks (8 cycles). Each participant will then undergo definitive surgery 3-6 weeks after conclusion of the last cycle of the neoadjuvant study treatment. After definitive surgery, each participant will receive adjuvant study treatment (Pembrolizumab OR Placebo) for approximately 27 weeks (9 cycles). Following adjuvant study treatment, each participant will be monitored for safety, survival and disease recurrence.
The primary study hypothesis is that pembrolizumab is superior to placebo, in combination with chemotherapy, as measured by the rate of Pathological Complete Response (pCR) and/or Event-free Survival (EFS), in participants with locally advanced TNBC. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/08/2025
Locations: Virginia G. Piper Cancer Center Pharmacy - Scottsdale Healthcare ( Site 0089), Scottsdale, Arizona +192 locations
Virginia G. Piper Cancer Center Pharmacy - Scottsdale Healthcare ( Site 0089), Scottsdale, Arizona
Arizona Oncology Associates PC- HOPE ( Site 8001), Tucson, Arizona
Cedars Sinai Medical Center ( Site 0091), Los Angeles, California
Pacific Cancer Care ( Site 0069), Monterey, California
ICRI ( Site 0072), Whittier, California
University of Colorado Cancer Center ( Site 0021), Aurora, Colorado
Yale University School of Medicine ( Site 0054), New Haven, Connecticut
Christiana Hospital ( Site 0029), Newark, Delaware
Univ of Miami-Sylvester Comprehensive Cancer Center- Kendall satellite ( Site 0079), Miami, Florida
The University of Chicago Medical Center ( Site 0047), Chicago, Illinois
North Shore University Health System ( Site 0081), Evanston, Illinois
Orchard Healthcare Research Inc. ( Site 0049), Skokie, Illinois
Goshen Center for Cancer Care ( Site 0010), Goshen, Indiana
University of Iowa Hospital and Clinics ( Site 0038), Iowa City, Iowa
New England Cancer Specialists ( Site 0005), Scarborough, Maine
Henry Ford Hospital ( Site 0003), Detroit, Michigan
Minnesota Oncology Hematology, PA ( Site 8013), Minneapolis, Minnesota
Rutgers Cancer Institute of New Jersey ( Site 0073), New Brunswick, New Jersey
Broome Oncology, LLC ( Site 8002), Johnson City, New York
Nyack Hospital Infusion Center ( Site 0059), Nyack, New York
TriHealth Cancer Institute-Good Samaritan Hospital ( Site 0044), Cincinnati, Ohio
Oncology Hematology Care, Inc. ( Site 8011), Cincinnati, Ohio
Providence Portland Medical Center ( Site 0052), Portland, Oregon
Northwest Cancer Specialists, P.C. ( Site 8008), Portland, Oregon
Magee - Women's Hospital ( Site 0011), Pittsburgh, Pennsylvania
Rhode Island Hospital ( Site 0060), Providence, Rhode Island
The West Clinic, P.C. ( Site 0078), Germantown, Tennessee
Texas Oncology-Austin Central ( Site 8005), Austin, Texas
Parkland Health and Hospital System ( Site 0093), Dallas, Texas
Texas Oncology-Baylor Charles A. Sammons Cancer Center ( Site 8006), Dallas, Texas
Simmons Cancer Center ( Site 0094), Dallas, Texas
UT Southwestern Medical Center ( Site 0030), Dallas, Texas
Moncrief Cancer Institute ( Site 0092), Fort Worth, Texas
Texas Oncology-Memorial City ( Site 8003), Houston, Texas
Houston Methodist Cancer Center ( Site 0013), Houston, Texas
Texas Oncology- Plano East ( Site 8010), Plano, Texas
Texas Oncology-San Antonio Northeast ( Site 8012), San Antonio, Texas
Texas Oncology-Tyler ( Site 8007), Tyler, Texas
University of Virginia ( Site 0022), Charlottesville, Virginia
Virginia Cancer Specialists, PC ( Site 8009), Fairfax, Virginia
Bon Secours Cancer Institute Medical Oncology at St. Mary's ( Site 0033), Midlothian, Virginia
Peninsula Cancer Institute, LLC ( Site 0041), Newport News, Virginia
Virginia Oncology Associates ( Site 8000), Norfolk, Virginia
Kadlec Clinic Hematology and Oncology ( Site 0087), Kennewick, Washington
Seattle Cancer Care Alliance ( Site 0068), Seattle, Washington
Medical Oncology Associates (Summit Cancer Centers) ( Site 0014), Spokane, Washington
YVMH dba Vrigina Mason Memorial/North Star Lodge Cancer Center ( Site 8004), Yakima, Washington
Royal North Shore Hospital ( Site 2000), Sydney, New South Wales
Westmead Hospital ( Site 2002), Sydney, New South Wales
Royal Adelaide Hospital ( Site 2008), Adelaide, South Australia
Cabrini Health ( Site 2009), East Malvern, Victoria
Frankston Hospital ( Site 2010), Franskton, Not set
Royal Brisbane and Women s Hospital ( Site 2003), Herston, Not set
St John of God Subiaco Hospital ( Site 2006), Perth, Not set
Hospital Nossa Senhora da Conceicao ( Site 0203), Porto Alegre, Rio Grande Do Sul
UOPECCAN - Uniao Oeste Paranaense de Estudos e Combate ao Cancer ( Site 0206), Cascavel, Not set
Universidade de Caxias do Sul ( Site 0201), Caxias do Sul, Not set
Hospital Erasto Gaertner ( Site 0207), Curitiba, Not set
Instituto do Cancer do Ceara ( Site 0205), Fortaleza, Not set
Hospital Araujo Jorge ( Site 0204), Goiania, Not set
Hospital Sao Lucas da PUCRS ( Site 0200), Porto Alegre, Not set
Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto ( Site 0208), Sao Jose do Rio Preto, Not set
Instituto do Cancer de Sao Paulo - ICESP ( Site 0211), Sao Paulo, Not set
Tom Baker Cancer Centre ( Site 0105), Calgary, Alberta
The Ottawa Hospital - Cancer Care ( Site 0100), Ottawa, Ontario
Princess Margaret Cancer Centre ( Site 0103), Toronto, Ontario
Centre Hospitalier de l Universite de Montreal - CHUM ( Site 0106), Montreal, Quebec
Jewish General Hospital ( Site 0101), Montreal, Quebec
CIUSSS de l'Estrie-CHUS ( Site 0102), Sherbrooke, Quebec
CHU de Quebec Universite Laval - Hopital du Saint-Sacrement ( Site 0104), Quebec, Not set
Oncomedica S.A. ( Site 0404), Monteria, Cordoba
Oncologos del Occidente S.A. ( Site 0405), Pereira, Risaralda
Hospital Universitario San Ignacio ( Site 0401), Bogota, Not set
Instituto Nacional de Cancerologia [Bogota-Colombia] ( Site 0403), Bogota, Not set
Hemato Oncologos S.A. ( Site 0400), Cali, Not set
Instituto De Cancerologia S.A. ( Site 0406), Medellin, Not set
CHU Jean Minjoz ( Site 0917), Besancon, Not set
Polyclinique Bordeaux Nord Aquitaine ( Site 0911), Bordeaux, Not set
Centre Francois Baclesse ( Site 0907), Caen, Not set
Centre Jean Perrin ( Site 0903), Clermont-Ferrand Cedex 01, Not set
Clinique Victor Hugo ( Site 0901), Le Mans, Not set
Hopital prive du Confluent ( Site 0902), Nantes, Not set
Institut Curie ( Site 0909), Paris, Not set
Hopital Saint Louis ( Site 0908), Paris, Not set
Hopital Diaconesses Croix Saint Simon ( Site 0905), Paris, Not set
CHU de la Miletrie Poitiers ( Site 0913), Poitiers, Not set
Institut Claudius Regaud IUCT Oncopole ( Site 0914), Toulouse Cedex 9, Not set
HELIOS Klinikum Berlin-Buch ( Site 1005), Berlin, Not set
Gynaekologisches Zentrum ( Site 1004), Bonn, Not set
Universitaetsklinikum Erlangen ( Site 1001), Erlangen, Not set
Kliniken Essen Mitte ( Site 1012), Essen, Not set
Universitaetsklinik und Poliklinik Halle/Saale ( Site 1008), Halle, Not set
Universitaetsklinikum Hamburg-Eppendorf ( Site 1007), Hamburg, Not set
Klinikum der Universit. Muenchen ( Site 1002), Muenchen, Not set
Caritasklinik St. Theresia ( Site 1011), Saarbruecken, Not set
Universitaets-Frauenklinik Tuebingen ( Site 1003), Tubingen, Not set
Bon Secours Hospital ( Site 1551), Cork, Not set
St Vincents University Hospital ( Site 1550), Dublin, Not set
Oncology institute ( Site 1601), Beer Sheva, Not set
Assaf Harofeh MC ( Site 1605), Beer Yaakov-Zerifin, Not set
Hadassah Ein Karem - Sharett Institute of Oncology ( Site 1600), Jerusalem, Not set
Rabin-Medical Center ( Site 1604), Petah Tikva, Not set
Sheba Medical Center ( Site 1602), Ramat-Gan, Not set
Sourasky Medical Center ( Site 1603), Tel Aviv, Not set
Istituto Scientifico Romagnolo per Studio e Cura Tumori IRST ( Site 1101), Meldola, FC
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia ( Site 1103), Brescia, Not set
Ospedale San Luca, AZIENDA USL2 TOSCANA NORD OVEST ( Site 1105), Lucca, Not set
Ospedale Civile di Macerata ( Site 1104), Macerata, Not set
Istituto Europeo di Oncologia ( Site 1106), Milano, Not set
Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 1102), Napoli, Not set
Aichi Cancer Center Hospital ( Site 2502), Nagoya, Aichi
National Cancer Center Hospital East ( Site 2518), Kashiwa, Chiba
National Hospital Organization Hokkaido Cancer Center ( Site 2512), Sapporo, Hokkaido
Hyogo College of Medicine Hospital ( Site 2506), Nishinomiya, Hyogo
Tokai University Hospital ( Site 2517), Isehara, Kanagawa
St. Marianna University School of Medicine Hospital ( Site 2516), Kawasaki, Kanagawa
Kindai University Hospital ( Site 2507), Osakasayama, Osaka
Saitama Medical University International Medical Center ( Site 2513), Hidaka, Saitama
Saitama Cancer Center ( Site 2510), Kitaadachi-gun, Saitama
Shizuoka Cancer Center Hospital and Research Institute ( Site 2514), Sunto-gun, Shizuoka
Chiba Cancer Center ( Site 2519), Chiba, Not set
Hiroshima City Hiroshima Citizens Hospital ( Site 2501), Hiroshima, Not set
Social medical corporation Hakuaikai Sagara Hospital ( Site 2508), Kagoshima, Not set
Kumamoto University Hospital ( Site 2515), Kumamoto, Not set
National Hospital Organization Osaka National Hospital ( Site 2505), Osaka, Not set
National Cancer Center Hospital ( Site 2500), Tokyo, Not set
St.Luke's International Hospital ( Site 2511), Tokyo, Not set
Toranomon Hospital ( Site 2503), Tokyo, Not set
The Cancer Institute Hospital of JFCR ( Site 2509), Tokyo, Not set
Seoul National University Hospital ( Site 2101), Seoul, Not set
Severance Hospital Yonsei University Health System ( Site 2100), Seoul, Not set
Asan Medical Center ( Site 2102), Seoul, Not set
Samsung Medical Center ( Site 2103), Seoul, Not set
Mazowiecki Szpital Onkologiczny ( Site 1713), Wieliszew, Mazowieckie
Centrum Onkologii Instytut im. Marii Skłodowskiej Curie ( Site 1717), Gliwice, Slaskie
Centrum Onkologii im. Prof. Franciszka Lukaszczyka ( Site 1708), Bydgoszcz, Not set
Centrum Onkologii im. Prof. Franciszka Lukaszczyka ( Site 1712), Bydgoszcz, Not set
Szpital Morski im. PCK. Szpitale Pomorskie Sp. Z o.o ( Site 1701), Gdynia, Not set
Centrum Onkologii Instytut im. Marii Sklodowskiej Curie ( Site 1719), Krakow, Not set
Centrum Onkologii Ziemi Lubelskiej im. sw. Jana z Dukli ( Site 1700), Lublin, Not set
Dolnoslaskie Centrum Onkologii. ( Site 1702), Wroclaw, Not set
Fundacao Champalimaud ( Site 2444), Lisboa, Not set
Hospital de Santa Maria, E.P.E. ( Site 2445), Lisboa, Not set
Instituto Portugues de Oncologia Do Porto Francisco Gentil E.P.E. ( Site 2446), Porto, Not set
Arkhangelsk Clinical Oncological Dispensary ( Site 1810), Arkhangelsk, Not set
Chelyabinsk Regional Clinical Oncological Dispensary ( Site 1805), Chelyabinsk, Not set
Republican Clinical Oncology Dispensary of Tatarstan MoH ( Site 1806), Kazan, Not set
Russian Oncological Research Center n.a. N.N.Blokhin of MoH ( Site 1801), Moscow, Not set
GBU RO Regional Clinical Oncological Dispensary ( Site 1808), Ryazan, Not set
Scientific Research Oncology Institute n.a. N.N.Petrov ( Site 1803), Saint Petersburg, Not set
Republican Clinical Oncology Dispensary of Republic of Bashkortostan ( Site 1804), Ufa, Not set
National Cancer Centre Singapore ( Site 2600), Singapore, Not set
ICO L Hospitalet ( Site 1305), Hospitalet de Llobregat, Barcelona
Hospital Quiron de Madrid ( Site 1303), Pozuelo de Alarcon, Madrid
Hospital del Mar ( Site 1306), Barcelona, Not set
Instituto Oncologico Baselga.Hospital Quiron. ( Site 1312), Barcelona, Not set
Hospital General Universitari Vall d Hebron ( Site 1301), Barcelona, Not set
Hospital Universitario Reina Sofia ( Site 1304), Cordoba, Not set
Hospital Universitario Ramon y Cajal ( Site 1300), Madrid, Not set
Complejo Hospitalario Universitario de Santiago ( Site 1308), Santiago de Compostela, Not set
Hospital Universitario Virgen del Rocio ( Site 1314), Sevilla, Not set
Hospital Clinico Univ de Valencia ( Site 1313), Valencia, Not set
Linkopings Universitetssjukhus ( Site 1402), Linkoping, Not set
Karolinska Universitetssjukhuset Solna ( Site 1404), Solna, Not set
Norrlands Universitetssjukhus ( Site 1401), Umea, Not set
Akademiska Sjukhuset ( Site 1403), Uppsala, Not set
Taipei Veterans General Hospital ( Site 2302), Taipei, Beitou
National Cheng Kung University Hospital ( Site 2305), Tainan, Not set
National Taiwan University Hospital ( Site 2301), Taipei, Not set
MacKay Memorial Hospital ( Site 2303), Taipei, Not set
Koo Foundation Sun Yat-Sen Cancer Center ( Site 2304), Taipei, Not set
Linkou Chang Gung Memorial Hospital ( Site 2300), Taoyuan, Not set
Samsun Ondokuz Mayıs Universitesi Tıp Fakultesi Hastanesi ( Site 1910), Samsun, Atakum
Adana Acıbadem Hospital Department of Medical Oncology ( Site 1906), Adana, Not set
Baskent Unıversity Adana Kısla Hospital ( Site 1903), Adana, Not set
Hacettepe Universitesi Tip Fakultesi Hastanesi ( Site 1912), Ankara, Not set
Abdurrahman Yurtaslan Oncology Training and Research Hospital ( Site 1909), Ankara, Not set
Ozel Medicana International Ankara Hastanesi ( Site 1915), Ankara, Not set
Antalya Memorial Hospital Department of Medical Oncology ( Site 1908), Antalya, Not set
Trakya University Medical Faculty Balkan Oncology Hospital ( Site 1901), Edirne, Not set
Acibadem Altunizade Hastanesi ( Site 1900), Istambul, Not set
İstanbul University Cerrahpaşa Medical Faculty ( Site 1904), Istanbul, Not set
Amerikan Hospital Medical ( Site 1902), Istanbul, Not set
Memorial Sisli Hastanesi ( Site 1913), Istanbul, Not set
Ege University Medical Faculty Tulay Aktas Oncology Hospital ( Site 1905), Izmir, Not set
Izmir Medical Park Hospital Department of Medical Oncology ( Site 1907), Izmir, Not set
Colchester General Hospital ( Site 1508), Colchester, Essex
Barts Cancer Institute ( Site 1500), London, Not set
St George s Hospital ( Site 1516), London, Not set
Maidstone Hospital ( Site 1511), Maidstone, Not set
The James Cook University Hospital ( Site 1515), Middlesbrough, Not set
Nottingham University Hospitals NHS Trust ( Site 1505), Nottingham, Not set
Royal Cornwall Hospitals NHS Trust ( Site 1504), Truro, Not set
Conditions: Triple Negative Breast Neoplasms
Comparison of Radiation Therapy Regimens in Combination With Chemotherapy in Treating Young Patients With Newly Diagnosed Standard-Risk Medulloblastoma
Completed
This randomized phase III trial is studying how well standard-dose radiation therapy works compared to reduced-dose radiation therapy in children 3-7 years of age AND how well standard volume boost radiation therapy works compared to smaller volume boost radiation therapy when given together with chemotherapy in treating young patients who have undergone surgery for newly diagnosed standard-risk medulloblastoma. Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemo... Read More
This randomized phase III trial is studying how well standard-dose radiation therapy works compared to reduced-dose radiation therapy in children 3-7 years of age AND how well standard volume boost radiation therapy works compared to smaller volume boost radiation therapy when given together with chemotherapy in treating young patients who have undergone surgery for newly diagnosed standard-risk medulloblastoma. Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemotherapy, such as vincristine, cisplatin, lomustine, and cyclophosphamide, work in different ways to stop tumor cells from dividing so they stop growing or die. Giving radiation therapy with chemotherapy after surgery may kill any remaining tumor cells. It is not yet known whether standard-dose radiation therapy is more effective than reduced-dose radiation therapy when given together with chemotherapy after surgery in treating young patients with medulloblastoma. Read Less
Gender:
ALL
Ages:
Between 3 years and 21 years
Trial Updated:
01/03/2025
Locations: Children's Hospital of Alabama, Birmingham, Alabama +196 locations
Children's Hospital of Alabama, Birmingham, Alabama
University of Alabama at Birmingham Cancer Center, Birmingham, Alabama
Phoenix Childrens Hospital, Phoenix, Arizona
Banner University Medical Center - Tucson, Tucson, Arizona
Kaiser Permanente Downey Medical Center, Downey, California
Loma Linda University Medical Center, Loma Linda, California
Miller Children's and Women's Hospital Long Beach, Long Beach, California
Children's Hospital Los Angeles, Los Angeles, California
Cedars Sinai Medical Center, Los Angeles, California
Valley Children's Hospital, Madera, California
UCSF Benioff Children's Hospital Oakland, Oakland, California
Kaiser Permanente-Oakland, Oakland, California
Children's Hospital of Orange County, Orange, California
Lucile Packard Children's Hospital Stanford University, Palo Alto, California
Sutter Medical Center Sacramento, Sacramento, California
University of California Davis Comprehensive Cancer Center, Sacramento, California
Rady Children's Hospital - San Diego, San Diego, California
UCSF Medical Center-Parnassus, San Francisco, California
UCSF Medical Center-Mission Bay, San Francisco, California
Santa Barbara Cottage Hospital, Santa Barbara, California
Children's Hospital Colorado, Aurora, Colorado
Connecticut Children's Medical Center, Hartford, Connecticut
Yale University, New Haven, Connecticut
Alfred I duPont Hospital for Children, Wilmington, Delaware
MedStar Georgetown University Hospital, Washington, District of Columbia
Children's National Medical Center, Washington, District of Columbia
Broward Health Medical Center, Fort Lauderdale, Florida
Lee Memorial Health System, Fort Myers, Florida
Golisano Children's Hospital of Southwest Florida, Fort Myers, Florida
University of Florida Health Science Center - Gainesville, Gainesville, Florida
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood, Florida
Nemours Children's Clinic-Jacksonville, Jacksonville, Florida
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida
Nicklaus Children's Hospital, Miami, Florida
AdventHealth Orlando, Orlando, Florida
Arnold Palmer Hospital for Children, Orlando, Florida
Nemours Children's Clinic - Orlando, Orlando, Florida
Orlando Health Cancer Institute, Orlando, Florida
Nemours Children's Hospital, Orlando, Florida
Nemours Children's Clinic - Pensacola, Pensacola, Florida
Johns Hopkins All Children's Hospital, Saint Petersburg, Florida
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa, Florida
Saint Mary's Hospital, West Palm Beach, Florida
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia
Augusta University Medical Center, Augusta, Georgia
Memorial Health University Medical Center, Savannah, Georgia
University of Hawaii Cancer Center, Honolulu, Hawaii
Kapiolani Medical Center for Women and Children, Honolulu, Hawaii
Tripler Army Medical Center, Honolulu, Hawaii
Saint Luke's Cancer Institute - Boise, Boise, Idaho
Lurie Children's Hospital-Chicago, Chicago, Illinois
University of Illinois, Chicago, Illinois
University of Chicago Comprehensive Cancer Center, Chicago, Illinois
Loyola University Medical Center, Maywood, Illinois
Advocate Children's Hospital-Oak Lawn, Oak Lawn, Illinois
Advocate Children's Hospital-Park Ridge, Park Ridge, Illinois
Advocate Lutheran General Hospital, Park Ridge, Illinois
Saint Jude Midwest Affiliate, Peoria, Illinois
Southern Illinois University School of Medicine, Springfield, Illinois
Riley Hospital for Children, Indianapolis, Indiana
Ascension Saint Vincent Indianapolis Hospital, Indianapolis, Indiana
Blank Children's Hospital, Des Moines, Iowa
University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa
University of Kentucky/Markey Cancer Center, Lexington, Kentucky
Norton Children's Hospital, Louisville, Kentucky
Tulane University School of Medicine, New Orleans, Louisiana
Children's Hospital New Orleans, New Orleans, Louisiana
Eastern Maine Medical Center, Bangor, Maine
Maine Children's Cancer Program, Scarborough, Maine
University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland
Walter Reed National Military Medical Center, Bethesda, Maryland
Tufts Children's Hospital, Boston, Massachusetts
Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Dana-Farber Cancer Institute, Boston, Massachusetts
C S Mott Children's Hospital, Ann Arbor, Michigan
Wayne State University/Karmanos Cancer Institute, Detroit, Michigan
Henry Ford Health Saint John Hospital, Detroit, Michigan
Michigan State University Clinical Center, East Lansing, Michigan
Hurley Medical Center, Flint, Michigan
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids, Michigan
Bronson Methodist Hospital, Kalamazoo, Michigan
Kalamazoo Center for Medical Studies, Kalamazoo, Michigan
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis, Minnesota
University of Minnesota/Masonic Cancer Center, Minneapolis, Minnesota
Mayo Clinic in Rochester, Rochester, Minnesota
Children's Hospital and Clinic-Saint Paul, Saint Paul, Minnesota
University of Mississippi Medical Center, Jackson, Mississippi
Children's Mercy Hospitals and Clinics, Kansas City, Missouri
Cardinal Glennon Children's Medical Center, Saint Louis, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Children's Hospital and Medical Center of Omaha, Omaha, Nebraska
University of Nebraska Medical Center, Omaha, Nebraska
Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas, Nevada
Nevada Cancer Research Foundation NCORP, Las Vegas, Nevada
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire
Hackensack University Medical Center, Hackensack, New Jersey
Morristown Medical Center, Morristown, New Jersey
Saint Peter's University Hospital, New Brunswick, New Jersey
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick, New Jersey
Newark Beth Israel Medical Center, Newark, New Jersey
Saint Joseph's Regional Medical Center, Paterson, New Jersey
Overlook Hospital, Summit, New Jersey
University of New Mexico Cancer Center, Albuquerque, New Mexico
Albany Medical Center, Albany, New York
Montefiore Medical Center - Moses Campus, Bronx, New York
Roswell Park Cancer Institute, Buffalo, New York
NYU Langone Hospital - Long Island, Mineola, New York
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York
University of Rochester, Rochester, New York
State University of New York Upstate Medical University, Syracuse, New York
New York Medical College, Valhalla, New York
UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina
Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina
Novant Health Presbyterian Medical Center, Charlotte, North Carolina
Duke University Medical Center, Durham, North Carolina
East Carolina University, Greenville, North Carolina
Wake Forest University Health Sciences, Winston-Salem, North Carolina
Sanford Broadway Medical Center, Fargo, North Dakota
Children's Hospital Medical Center of Akron, Akron, Ohio
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Rainbow Babies and Childrens Hospital, Cleveland, Ohio
Cleveland Clinic Foundation, Cleveland, Ohio
Nationwide Children's Hospital, Columbus, Ohio
Dayton Children's Hospital, Dayton, Ohio
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo, Ohio
Mercy Children's Hospital, Toledo, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Legacy Emanuel Children's Hospital, Portland, Oregon
Legacy Emanuel Hospital and Health Center, Portland, Oregon
Oregon Health and Science University, Portland, Oregon
Lehigh Valley Hospital - Muhlenberg, Bethlehem, Pennsylvania
Geisinger Medical Center, Danville, Pennsylvania
Penn State Children's Hospital, Hershey, Pennsylvania
Saint Christopher's Hospital for Children, Philadelphia, Pennsylvania
Rhode Island Hospital, Providence, Rhode Island
Medical University of South Carolina, Charleston, South Carolina
Prisma Health Richland Hospital, Columbia, South Carolina
BI-LO Charities Children's Cancer Center, Greenville, South Carolina
Greenville Cancer Treatment Center, Greenville, South Carolina
Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota
T C Thompson Children's Hospital, Chattanooga, Tennessee
East Tennessee Childrens Hospital, Knoxville, Tennessee
Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee
Texas Tech University Health Sciences Center-Amarillo, Amarillo, Texas
Dell Children's Medical Center of Central Texas, Austin, Texas
Driscoll Children's Hospital, Corpus Christi, Texas
Medical City Dallas Hospital, Dallas, Texas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas
Brooke Army Medical Center, Fort Sam Houston, Texas
Cook Children's Medical Center, Fort Worth, Texas
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas
M D Anderson Cancer Center, Houston, Texas
Covenant Children's Hospital, Lubbock, Texas
Methodist Children's Hospital of South Texas, San Antonio, Texas
University of Texas Health Science Center at San Antonio, San Antonio, Texas
Scott and White Memorial Hospital, Temple, Texas
Primary Children's Hospital, Salt Lake City, Utah
University of Vermont and State Agricultural College, Burlington, Vermont
Inova Fairfax Hospital, Falls Church, Virginia
Children's Hospital of The King's Daughters, Norfolk, Virginia
Naval Medical Center - Portsmouth, Portsmouth, Virginia
Virginia Commonwealth University/Massey Cancer Center, Richmond, Virginia
Carilion Children's, Roanoke, Virginia
Seattle Children's Hospital, Seattle, Washington
Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington
Madigan Army Medical Center, Tacoma, Washington
West Virginia University Charleston Division, Charleston, West Virginia
Saint Vincent Hospital Cancer Center Green Bay, Green Bay, Wisconsin
University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin
Marshfield Medical Center-Marshfield, Marshfield, Wisconsin
Children's Hospital of Wisconsin, Milwaukee, Wisconsin
Women's and Children's Hospital-Adelaide, North Adelaide, South Australia
Princess Margaret Hospital for Children, Perth, Western Australia
University of Alberta Hospital, Edmonton, Alberta
British Columbia Children's Hospital, Vancouver, British Columbia
CancerCare Manitoba, Winnipeg, Manitoba
Janeway Child Health Centre, Saint John's, Newfoundland and Labrador
IWK Health Centre, Halifax, Nova Scotia
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton, Ontario
Kingston Health Sciences Centre, Kingston, Ontario
Children's Hospital, London, Ontario
Children's Hospital of Eastern Ontario, Ottawa, Ontario
Hospital for Sick Children, Toronto, Ontario
The Montreal Children's Hospital of the MUHC, Montreal, Quebec
Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec
Saskatoon Cancer Centre, Saskatoon, Saskatchewan
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Quebec, Not set
Dutch Childhood Oncology Group, Utrecht, Not set
Starship Children's Hospital, Grafton, Auckland
Christchurch Hospital, Christchurch, Not set
San Jorge Children's Hospital, San Juan, Not set
Swiss Pediatric Oncology Group - Bern, Bern, Not set
Swiss Pediatric Oncology Group - Geneva, Geneva, Not set
Swiss Pediatric Oncology Group - Lausanne, Lausanne, Not set
Conditions: Medulloblastoma
Combination Chemotherapy, Autologous Stem Cell Transplant, and/or Radiation Therapy in Treating Young Patients With Extraocular Retinoblastoma
Completed
This phase III trial is studying the side effects and how well giving combination chemotherapy together with autologous stem cell transplant and/or radiation therapy works in treating young patients with extraocular retinoblastoma. Giving chemotherapy before an autologous stem cell transplant stops the growth of tumor cells by stopping them from dividing or killing them. After treatment, stem cells are collected from the patient's blood and/or bone marrow and stored. More chemotherapy is given t... Read More
This phase III trial is studying the side effects and how well giving combination chemotherapy together with autologous stem cell transplant and/or radiation therapy works in treating young patients with extraocular retinoblastoma. Giving chemotherapy before an autologous stem cell transplant stops the growth of tumor cells by stopping them from dividing or killing them. After treatment, stem cells are collected from the patient's blood and/or bone marrow and stored. More chemotherapy is given to prepare the bone marrow for the stem cell transplant. The stem cells are then returned to the patient to replace the blood-forming cells that were destroyed by the chemotherapy. Radiation therapy uses high energy x-rays to kill tumor cells. Giving radiation therapy after combination chemotherapy and/or autologous stem cell transplant may kill any remaining tumor cells. Read Less
Gender:
ALL
Ages:
10 years and below
Trial Updated:
01/03/2025
Locations: Children's Hospital of Alabama, Birmingham, Alabama +72 locations
Children's Hospital of Alabama, Birmingham, Alabama
University of Alabama at Birmingham Cancer Center, Birmingham, Alabama
Phoenix Childrens Hospital, Phoenix, Arizona
Arkansas Children's Hospital, Little Rock, Arkansas
University of Arkansas for Medical Sciences, Little Rock, Arkansas
Kaiser Permanente Downey Medical Center, Downey, California
Children's Hospital Los Angeles, Los Angeles, California
Lucile Packard Children's Hospital Stanford University, Palo Alto, California
UCSF Medical Center-Parnassus, San Francisco, California
UCSF Medical Center-Mission Bay, San Francisco, California
Children's Hospital Colorado, Aurora, Colorado
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center, Denver, Colorado
Connecticut Children's Medical Center, Hartford, Connecticut
Alfred I duPont Hospital for Children, Wilmington, Delaware
Children's National Medical Center, Washington, District of Columbia
Nemours Children's Clinic-Jacksonville, Jacksonville, Florida
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida
Nemours Children's Clinic - Orlando, Orlando, Florida
Nemours Children's Hospital, Orlando, Florida
Nemours Children's Clinic - Pensacola, Pensacola, Florida
Johns Hopkins All Children's Hospital, Saint Petersburg, Florida
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa, Florida
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia
Lurie Children's Hospital-Chicago, Chicago, Illinois
University of Illinois, Chicago, Illinois
Riley Hospital for Children, Indianapolis, Indiana
University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa
University of Kentucky/Markey Cancer Center, Lexington, Kentucky
Walter Reed National Military Medical Center, Bethesda, Maryland
Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Dana-Farber Cancer Institute, Boston, Massachusetts
University of Mississippi Medical Center, Jackson, Mississippi
Children's Mercy Hospitals and Clinics, Kansas City, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Sunrise Hospital and Medical Center, Las Vegas, Nevada
Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas, Nevada
Summerlin Hospital Medical Center, Las Vegas, Nevada
Nevada Cancer Research Foundation NCORP, Las Vegas, Nevada
Morristown Medical Center, Morristown, New Jersey
Memorial Sloan Kettering Cancer Center, New York, New York
New York Medical College, Valhalla, New York
Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina
Novant Health Presbyterian Medical Center, Charlotte, North Carolina
Duke University Medical Center, Durham, North Carolina
Children's Hospital Medical Center of Akron, Akron, Ohio
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Rainbow Babies and Childrens Hospital, Cleveland, Ohio
Cleveland Clinic Foundation, Cleveland, Ohio
Dayton Children's Hospital, Dayton, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Penn State Children's Hospital, Hershey, Pennsylvania
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Children's Oncology Group, Philadelphia, Pennsylvania
Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
Saint Jude Children's Research Hospital, Memphis, Tennessee
Medical City Dallas Hospital, Dallas, Texas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas
Cook Children's Medical Center, Fort Worth, Texas
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas
M D Anderson Cancer Center, Houston, Texas
Children's Hospital of San Antonio, San Antonio, Texas
Methodist Children's Hospital of South Texas, San Antonio, Texas
University of Texas Health Science Center at San Antonio, San Antonio, Texas
Virginia Commonwealth University/Massey Cancer Center, Richmond, Virginia
Saint Vincent Hospital Cancer Center Green Bay, Green Bay, Wisconsin
Children's Hospital of Wisconsin, Milwaukee, Wisconsin
Hospital de Pediatria Juan P Garrahan, Buenos Aires, Not set
The Children's Hospital at Westmead, Westmead, New South Wales
Princess Margaret Hospital for Children, Perth, Western Australia
Instituto De Oncologia Pediatrica, Sao Paulo, Not set
IWK Health Centre, Halifax, Nova Scotia
Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec
Children's Cancer Hospital, El Saida Zenab, Cairo
Conditions: Extraocular Retinoblastoma
A Study Evaluating the Safety, Tolerability, Pharmacokinetics and Preliminary Activity of Idasanutlin in Combination With Either Chemotherapy or Venetoclax in Treatment of Pediatric and Young Adult Participants With Relapsed/Refractory Acute Leukemias or Solid Tumors
Terminated
This is a Phase I/II, multicenter, open-label, multi-arm study designed to evaluate the safety, tolerability, pharmacokinetics, and preliminary efficacy of idasanutlin, administered as a single agent or in combination with chemotherapy or venetoclax, in pediatric and young adult participants with acute leukemias or solid tumors.
This study is divided into three parts: Part 1 will begin with dose escalation of idasanutlin as a single agent in pediatric participants with relapsed or refractory so... Read More
This is a Phase I/II, multicenter, open-label, multi-arm study designed to evaluate the safety, tolerability, pharmacokinetics, and preliminary efficacy of idasanutlin, administered as a single agent or in combination with chemotherapy or venetoclax, in pediatric and young adult participants with acute leukemias or solid tumors.
This study is divided into three parts: Part 1 will begin with dose escalation of idasanutlin as a single agent in pediatric participants with relapsed or refractory solid tumors to identify the maximum tolerated dose (MTD)/maximum administered dose (MAD) and to characterize dose-limiting toxicities (DLTs). Following MTD/MAD identification, three separate safety run-in cohorts in neuroblastoma, acute myeloid leukemia (AML), and acute lymphoblastic leukemia (ALL) will be conducted to identify the recommended Phase 2 dose (RP2D) of idasanutlin in each combination, with chemotherapy or venetoclax. Part 2 will evaluate the safety and early efficacy of idasanutlin in combination with chemotherapy or venetoclax in newly enrolled pediatric and young adult participants in neuroblastoma, AML,and ALL cohorts at idasanutlin RP2D. Part 3 will potentially be conducted as an additional expansion phase of the idasanutlin combination cohorts in neuroblastoma, AML, or ALL for further response and safety assessment. Read Less
Gender:
ALL
Ages:
Between 0 years and 30 years
Trial Updated:
12/18/2024
Locations: Arkansas Children's Hospital Research Institute, Little Rock, Arkansas +13 locations
Arkansas Children's Hospital Research Institute, Little Rock, Arkansas
Lucile Packard Children's Hospital at Stanford University; Thoracic Oncology, Palo Alto, California
Arnold Palmer Hosp-Children, Orlando, Florida
Memorial Sloan Kettering Cancer Center, New York, New York
University of Texas Health Science Center at San Antonio, San Antonio, Texas
Alberta Children'S Hospital, Calgary, Alberta
Centre Leon Berard, Lyon CEDEX 08, Not set
Institut Curie, Paris, Not set
Prinses Maxima Centrum, Utrecht, Not set
Hospital Sant Joan De Deu, Esplugues De Llobregas, Barcelona
Hospital Infantil Universitario Nino Jesus, Madrid, Not set
Birmingham Children's Hospital, Birmingham, Not set
The Royal Victoria Infirmary; Paediatric and Adolescent Oncology Unit, Newcastle Upon Tyne, Not set
Royal Marsden Hospital; Pediatric Unit, Surrey, Not set
Conditions: Acute Myeloid Leukemia (AML), Acute Lymphoblastic Leukemia (ALL), Neuroblastoma, Solid Tumors
Study of Nivolumab Versus Placebo in Combination With Neoadjuvant Chemotherapy and Adjuvant Endocrine Therapy in Participants With High-risk, Estrogen Receptor-Positive (ER+), Human Epidermal Growth Factor Receptor 2-Negative (HER2-) Primary Breast Cancer
Completed
A randomized multi-arm study evaluating the efficacy and safety of nivolumab versus placebo in combination with neoadjuvant (pre-surgery) chemotherapy and adjuvant (post-surgery) endocrine therapy in participants with high-risk, estrogen receptor-positive, human epidermal growth factor receptor 2-negative (ER+, HER2-) early stage breast cancer.
A randomized multi-arm study evaluating the efficacy and safety of nivolumab versus placebo in combination with neoadjuvant (pre-surgery) chemotherapy and adjuvant (post-surgery) endocrine therapy in participants with high-risk, estrogen receptor-positive, human epidermal growth factor receptor 2-negative (ER+, HER2-) early stage breast cancer. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/16/2024
Locations: Local Institution - 0136, Mobile, Alabama +239 locations
Local Institution - 0136, Mobile, Alabama
Local Institution - 0052, Greenbrae, California
Local Institution - 0051, Whittier, California
Local Institution - 0182, Stamford, Connecticut
Local Institution - 0150, Jacksonville, Florida
Local Institution - 0097, Miami, Florida
Local Institution - 0149, Pensacola, Florida
Local Institution - 0120, Tallahassee, Florida
Local Institution - 0054, Athens, Georgia
Local Institution - 0107, Atlanta, Georgia
Local Institution - 0056, Columbus, Georgia
Local Institution - 0221, Chicago, Illinois
Local Institution - 0227, Fort Wayne, Indiana
Local Institution - 0222, Topsham, Maine
Local Institution - 0146, Bethesda, Maryland
HCA Midwest Division, Kansas City, Missouri
Local Institution - 0109, Florham Park, New Jersey
Local Institution - 0050, Hackensack, New Jersey
Local Institution - 0180, New Brunswick, New Jersey
Local Institution - 0181, Albuquerque, New Mexico
Local Institution - 0041, Bronx, New York
Local Institution - 0283, Charlotte, North Carolina
Duke Cancer Institute, Durham, North Carolina
Local Institution - 0053, Cleveland, Ohio
Local Institution - 0218, Nashville, Tennessee
Local Institution - 0121, Fort Worth, Texas
Local Institution - 0224, Fairfax, Virginia
Local Institution - 0122, Fredericksburg, Virginia
Virginia Cancer Institute, Richmond, Virginia
Local Institution - 0274, Seattle, Washington
Local Institution - 0012, Ciudad Autonoma Beunos Aires, Buenos Aires
Local Institution - 0015, La Plata, Buenos Aires
Local Institution - 0020, Buenos Aires, Ciudad Autónoma De Buenos Aires
Local Institution - 0294, Córdoba, Cordoba
Local Institution - 0303, Río Cuarto, Cordoba
Local Institution - 0011, Caba, Distrito Federal
Local Institution - 0008, Capital Federal, Distrito Federal
Local Institution - 0013, Ciudad Autonoma de Buenos Aires, Distrito Federal
Local Institution - 0014, Rosario Santa Fe, Santa FE
Local Institution - 0021, Cordoba, Not set
Local Institution, La Rioja, Not set
Local Institution, Viedma, Not set
Local Institution - 0071, North Sydney, New South Wales
Local Institution - 0069, Port Macquarie, New South Wales
Local Institution - 0072, Herston, Queensland
Local Institution - 0067, Elizabeth Vale, South Australia
Local Institution - 0066, Clayton, Victoria
Local Institution - 0142, Clayton, Victoria
Local Institution - 0070, Melbourne, Victoria
Local Institution - 0068, North Ballarat, Victoria
Local Institution - 0045, Graz, Not set
Local Institution - 0042, Innsbruck, Not set
Local Institution - 0048, Salzburg, Not set
Local Institution - 0046, Wien, Not set
Local Institution - 0047, Wien, Not set
Local Institution - 0187, Brussels, Not set
Local Institution - 0030, Charleroi, Not set
Local Institution - 0037, Edegem, Not set
Local Institution - 0032, Gent, Not set
Local Institution - 0031, Liege, Not set
Local Institution - 0130, Fortaleza, Ceara
Local Institution - 0225, Brasilia, Distrito Federal
Local Institution - 0287, Goiânia, Goias
Local Institution - 0133, Belo Horizonte, Minas Gerais
Local Institution - 0132, Ijui, RIO Grande DO SUL
Local Institution - 0288, Porto Alegre, RIO Grande DO SUL
Local Institution - 0131, Porto Alegre, Rio Grande Do Sul
Local Institution - 0135, Porto Alegre, RIO Grande DO SUL
Local Institution - 0273, Santa Cruz do Sul, Rio Grande Do Sul
Local Institution - 0134, Barretos, SAO Paulo
Local Institution - 0272, São Paulo, SAO Paulo
Local Institution - 0128, Santo André, São Paulo
Local Institution - 0129, Rio de Janeiro, Not set
Local Institution - 0144, São Paulo, Not set
Local Institution - 0104, São Paulo, Not set
Local Institution - 0194, Montreal, Quebec
Local Institution - 0095, Montréal, Quebec
Local Institution - 0058, Sherbrooke, Quebec
Local Institution - 0197, La Serena, Coquimbo
Local Institution - 0016, Santiago de Chile, Metropolitana
Local Institution - 0019, Santiago Region Metropolitana, Metropolitana
Local Institution - 0318, Santiago, Metropolitana
Local Institution - 0018, Vina del Mar, Valparaiso
Local Institution - 0326, Antofagasta, Not set
Local Institution - 0235, Bengbu, Anhui
Local Institution - 0239, Hefei, Anhui
Local Institution, Beijing, Beijing
Local Institution - 0319, Chongqing, Chongqing
Local Institution - 0232, Chongqing, Chongqing
Local Institution - 0267, Guangzhou, Guangdong
Local Institution - 0241, Guangzhou, Guangdong
Local Institution, Guangzhou, Guangdong
Local Institution - 0312, Zunyi, Guizhou
Local Institution - 0240, Shjiazhuang, Hebei
Local Institution - 0250, Wuhan, Hebei
Local Institution - 0248, Harbin, Heilongjiang
Local Institution, Zhengzhou, Henan
Local Institution - 0255, Changchun, Jilin
Local Institution - 0247, Changchun, Jilin
Local Institution - 0252, Shenyang, Liaoning
Local Institution - 0263, Xian, Shan3xi
Local Institution - 0245, Jinan, Shandong
Local Institution - 0256, Qingdao, Shandong
Local Institution - 0214, YanTai, Shandong
Local Institution - 0127, Shanghai, Shanghai
Local Institution - 0244, Chengdu, Sichuan
Local Institution - 0254, Tianjin, Tianjin
Local Institution - 0311, Urumqi, Xinjiang
Local Institution - 0238, Hangzhou, Zhejiang
Local Institution - 0231, Hangzhou, Zhejiang
Local Institution - 0237, Hangzhou, Zhejiang
Local Institution - 0215, Beijing, Not set
Local Institution - 0261, Barranquilla, Atlántico
Local Institution - 0203, Colombia, Bogota
Local Institution - 0113, Montería, Córdoba
Local Institution - 0094, Bogotá, Distrito Capital De Bogotá
Local Institution - 0098, Piedecuesta, Santander
Local Institution - 0093, Cali, Not set
Local Institution - 0271, Pereira, Not set
Local Institution - 0202, Rionegro, Not set
Local Institution - 0100, Hradec Kralove, Not set
Local Institution - 0103, Novy Jicin, Not set
Local Institution - 0101, Olomouc, Not set
Local Institution - 0099, Praha 10, Not set
Local Institution - 0167, Aarhus N, Midtjylland
Local Institution - 0165, Herlev, Not set
Local Institution - 0164, Kobenhavn O, Not set
Local Institution - 0166, Naestved, Not set
Local Institution - 0001, Helsinki, Not set
Local Institution - 0160, Tampere, Not set
Local Institution - 0216, Le Mans, Sarthe
Local Institution - 0004, Besancon, Not set
Local Institution - 0024, Brest, Not set
Local Institution - 0162, Clermont-Ferrand, Not set
Local Institution - 0153, Lyon, Not set
Local Institution - 0152, Montpellier, Not set
Local Institution - 0161, Paris, Not set
Local Institution - 0195, Plerin, Not set
Local Institution - 0002, Saint Herblain, Not set
Local Institution - 0258, Strasbourg, Not set
Local Institution - 0228, Toulon Cedex, Not set
Local Institution - 0003, Villejuif, Not set
Local Institution - 0084, München, Bayern
Local Institution - 0079, Saarbruecken, Saarland
Local Institution - 0083, Berlin, Not set
Local Institution - 0112, Dresden, Not set
Local Institution - 0081, Essen, Not set
Local Institution - 0158, Frankfurt, Not set
Local Institution - 0223, Hamburg, Not set
Local Institution - 0087, Heidelberg, Not set
Local Institution - 0089, Homburg, Not set
Local Institution - 0080, Köln, Not set
Local Institution - 0196, Leipzig, Not set
Local Institution - 0111, Moenchengladbach, Not set
Local Institution - 0156, Rostock, Not set
Local Institution - 0157, Velbert, Not set
Local Institution - 0105, Würzburg, Not set
Local Institution - 0115, Hong Kong, Not set
Local Institution - 0034, Dublin 8, Dublin
Local Institution - 0035, Beaumont, Not set
Local Institution - 0036, Cork, Not set
Local Institution - 0191, Catanzaro, Not set
Local Institution - 0207, Milano, Not set
Azienda Ospedaliero Universitaria Federico II di Napoli, Napoli, Not set
Local Institution - 0124, Napoli, Not set
Local Institution - 0155, Padova, Not set
Fondazione Irccs - Policlinico San Matteo, Pavia, Not set
Local Institution - 0190, Roma, Not set
Local Institution - 0125, Rozzano (MI), Not set
Local Institution - 0325, Seongnam, Not set
Local Institution - 0295, Seoul, Not set
Local Institution - 0320, Seoul, Not set
Local Institution - 0290, Seoul, Not set
Local Institution - 0291, Seoul, Not set
Local Institution - 0262, Tijuana, BAJA California
Local Institution - 0168, Mexico City, Distrito Federal
Local Institution - 0154, Mexico City, Distrito Federal
Local Institution - 0330, Zapopan, Jalisco
Local Institution - 0137, Monterrey, Nuevo LEON
Local Institution - 0212, Merida, Yucatán
Local Institution - 0280, Campeche, Not set
Local Institution - 0091, Chihuahua, Not set
Local Institution - 0145, Colima, Not set
Local Institution - 0141, Oaxaca, Not set
Local Institution - 0033, Amsterdam, Not set
Local Institution - 0177, Breda, Not set
Local Institution - 0199, Deventer, Not set
Local Institution - 0147, Utrecht, Not set
Local Institution - 0335, Bydgoszcz, Not set
Local Institution - 0061, Koszalin, Not set
Local Institution - 0059, Krakow, Not set
Local Institution - 0063, Lodz, Not set
Local Institution - 0062, Opole, Not set
Local Institution - 0060, Warszawa, Not set
Local Institution - 0334, Gliwice, Śląskie
Local Institution - 0210, Lisboa, Not set
Local Institution - 0211, Lisboa, Not set
Local Institution - 0209, Porto, Not set
Local Institution - 0110, Ponce, Not set
Local Institution - 0029, Bucharest, Not set
Local Institution - 0270, Bucharest, Not set
Local Institution - 0025, Bucuresti, Not set
Local Institution - 0028, Craiova, Not set
Local Institution - 0027, Floresti, Not set
Local Institution - 0026, Suceava, Not set
Local Institution, Krasnodar, Not set
Local Institution - 0119, Moscow, Not set
Local Institution, Moscow, Not set
Local Institution - 0285, Moskva, Not set
Local Institution, Ryazan, Not set
Local Institution - 0284, Saint Petersburg, Not set
Local Institution - 0306, Sankt-Peterburg, Not set
Local Institution, Sochi, Not set
Local Institution - 0078, Singapore, Not set
Local Institution - 0076, Singapore, Not set
Local Institution - 0077, Singapore, Not set
Local Institution - 0205, Elche, Alicante
Local Institution - 0171, Barcelona, Not set
Local Institution - 0172, Barcelona, Not set
Local Institution - 0173, Madrid, Not set
Local Institution - 0176, Madrid, Not set
Local Institution - 0169, Malaga, Not set
Local Institution - 0204, Pamplona, Not set
Local Institution - 0174, Santiago de Compostela, Not set
Local Institution - 0170, Sevilla, Not set
Local Institution - 0175, Valencia, Not set
Local Institution - 0184, Basel, Not set
Local Institution - 0186, Lausanne, Not set
Local Institution - 0185, Thun, Not set
Local Institution - 0301, Kaohsiung, Not set
Local Institution - 0300, Tainan City, Not set
Local Institution - 0298, Tainan, Not set
Local Institution - 0305, Taipei, Not set
Local Institution - 0297, Taipei, Not set
Local Institution - 0073, Adana, Not set
Local Institution - 0257, Ankara, Not set
Local Institution - 0075, Antalya, Not set
Local Institution - 0074, Istanbul, Not set
Local Institution - 0006, Withington, Manchester
Local Institution - 0005, London, Not set
Conditions: Breast Cancer
Study of Effectiveness of Axicabtagene Ciloleucel Compared to Standard of Care Therapy in Patients With Relapsed/Refractory Diffuse Large B Cell Lymphoma
Completed
The goal of this clinical study is to assess whether axicabtagene ciloleucel therapy improves the clinical outcome compared with standard of care second-line therapy in patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL).
The goal of this clinical study is to assess whether axicabtagene ciloleucel therapy improves the clinical outcome compared with standard of care second-line therapy in patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/06/2024
Locations: Banner MD Anderson Cancer Center, Gilbert, Arizona +71 locations
Banner MD Anderson Cancer Center, Gilbert, Arizona
Mayo Clinic Hospital, Phoenix, Arizona
UC San Diego Moores Cancer Center, La Jolla, California
UCLA, Santa Monica, California
Stanford Cancer Institute, Stanford, California
University of Miami Hospital and Clinics/Sylvester Comprehensive Cancer Center, Miami, Florida
Moffitt Cancer Center, Tampa, Florida
Northwestern University, Chicago, Illinois
University of Chicago Medical Center, Chicago, Illinois
University of Iowa Hospitals and Clinincs, Iowa City, Iowa
The University of Kansas Cancer Center, Kansas City, Kansas
University of Maryland, Greenbaum Comprehensive Cancer Center, Baltimore, Maryland
Dana-Farber Cancer Institute, Boston, Massachusetts
Barbara Ann Karmanos Cancer Institute, Detroit, Michigan
Mayo Clinic, Patient Location, Rochester, Minnesota
Washington University School of Medicine, Saint Louis, Missouri
John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, New Jersey
Memorial Sloan Kettering Cancer Center, New York, New York
Icahn School of Medicine at Mount Sinai, New York, New York
University of Rochester Medical Center, Rochester, New York
Cleveland Clinic, Cleveland, Ohio
James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive Cancer Center, Columbus, Ohio
Thomas Jefferson University, Philadelphia, Pennsylvania
UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania
Sarah Cannon Research Institute, Nashville, Tennessee
Henry-Joyce Cancer Center, Nashville, Tennessee
The University of Texas, MD Anderson Cancer Center, Houston, Texas
University of Utah, Huntsman Cancer Institute, Salt Lake City, Utah
University of Virginia Health System, Charlottesville, Virginia
Swedish Cancer Institute, Seattle, Washington
Peter MacCallum Cancer Center, Melbourne, Victoria
Universitatsklinikum Graz, Division of Hematology, Graz, Not set
Medizinische Universitat Innsbruck, Innere Medizin V - Hamatologie und Onkologie, Innsbruck, Not set
Cliniques Universiaires Saint-Luc, Brussels, Not set
UZ Gasthuisberg, Leuven, Not set
Vancouver General Hospital, Vancouver, British Columbia
CancerCare Manitoba, Winnipeg, Manitoba
Uninversity Health Network - Princess Margaret Cancer Center, Toronto, Ontario
McGill University Health Center, Montreal, Quebec
QEII Health Sciences Centre, Halifax, Not set
Centre Integre Universitaire de Sante et Services Sociaux de l'Est-de-l'lle-de-Montreal / Hopital Maisonneuve-Rosemont, Montréal, Not set
The Ottawa Hospital - General Campus, Ottawa, Not set
CHU de Quebec-Universite Laval, Hopital de L'Enfante-Jesus, Québec, Not set
CHRU de Lille - Hopital Claude Huriez, Lille cedex, Not set
Hopital Saint-Louis, Paris, Not set
Centre Hospitalier Lyon-Sud - Service d'Hematologie clinique, Pierre Benite, Not set
Centre Hospitalier Universitaire de Rennes - Hopital Pontchaillou, Rennes, Not set
Universitäts-klinikum Dresden, Dresden, Not set
Universitatsmedizin Gottingen, Göttingen, Not set
Universitatsklinikum Hamburg-Eppendorf, Hamburg, Not set
Universitätsklinikum Heidelberg, Heidelberg, Not set
Universitäts-klinikum Würzburg, Würzburg, Not set
Tel Aviv Sourasky Medical Center, Tel Aviv, Not set
Instituto di Ematologia "L. e A. Seragnoli" - Dipartimento di Medicina Specialistica Diagnostica e Sperimentale, Bologna, Not set
IRCCS Ospedale San Raffaele di Milano, Milano, Not set
Academic Medical Center, Amsterdam, Not set
University Medical Center Groningen, Groningen, Not set
Erasmus Medical Center, Rotterdam, Not set
University Medical Center Utrecht, Utrecht, Not set
Hospital Clinic de Barcelona, Barcelona, Not set
Institut Catala d'Oncologia, Barcelona, Not set
Hospital Universitario La Paz, Madrid, Not set
Clinica Universidad de Navarra, Pamplona, Not set
Hospital Universitario de Salamanca, Salamanca, Not set
Uppsala Akademiska Sjukhus, Uppsala, Not set
IOSI, OSpedale Regionale Bellinzona e Valli, Bellinzona, Not set
University Hospital Zurich, Zürich, Not set
University Hospitals Birmingham NHS Foundation Trust, Birmingham, Not set
Barts Health NHS Trust, London, Not set
University College London Hospitals NHS Foundation Trust, London, Not set
The Christie NHS Foundation Trust, Manchester, Not set
The Royal Marsden NHS Foundation Trust, Sutton, Not set
Conditions: Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL)
Study of Copanlisib in Combination With Standard Immunochemotherapy in Relapsed Indolent Non-Hodgkin's Lymphoma (iNHL)
Terminated
The purpose of this study is to assess whether copanlisib in combination with standard immunochemotherapy (rituximab in combination with bendamustine \[R-B\] and rituximab in combination with a 4 drug combination of cyclophosphamide, doxorubicin, vincristine and prednisone/prednisolone \[R-CHOP\]) is effective and safe, compared with placebo in combination with standard immunochemotherapy (R-B or R-CHOP) in patients with relapsed iNHL who have received at least one, but at most three, lines of t... Read More
The purpose of this study is to assess whether copanlisib in combination with standard immunochemotherapy (rituximab in combination with bendamustine \[R-B\] and rituximab in combination with a 4 drug combination of cyclophosphamide, doxorubicin, vincristine and prednisone/prednisolone \[R-CHOP\]) is effective and safe, compared with placebo in combination with standard immunochemotherapy (R-B or R-CHOP) in patients with relapsed iNHL who have received at least one, but at most three, lines of treatment, including rituximab-based immunochemotherapy and alkylating agents. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/15/2024
Locations: Ironwood Physicians P.C. DBA Ironwood Cancer & Res. Ctr., Chandler, Arizona +200 locations
Ironwood Physicians P.C. DBA Ironwood Cancer & Res. Ctr., Chandler, Arizona
Brian J. LeBerthon, MD, West Covina, California
SCL Health Research at St Joseph's Hospital Denver CO, Denver, Colorado
Lewis Hall Singletary Oncology Center, Thomasville, Georgia
Memorial Sloan Kettering Cancer Center- Bergen, New York, New York
Memorial Sloan-Kettering Cancer Center, New York, New York
New York Cancer and Blood Specialists, Port Jefferson Station, New York
Gabrail Cancer Center, Canton, Ohio
Oncology Consultants, Houston, Texas
Texas Oncology- McAllen, McAllen, Texas
Calvary Mater Hospital Newcastle, Waratah, New South Wales
Flinders Medical Centre, Bedford Park, South Australia
Ashford Cancer Centre Research Pty Ltd, Kurralta Park, South Australia
The Alfred Hospital, Melbourne, Victoria
Fiona Stanley Hospital, Murdoch, Western Australia
Eastern Health Integrated Renal Service, Box Hill, Not set
Institut Jules Bordet/Jules Bordet Instituut, Bruxelles, Not set
UZ Gent, Gent, Not set
UZ Leuven Gasthuisberg, Leuven, Not set
CHU de Liège, Liege, Not set
Centro Integrado de Oncologia de Curitiba, Curitiba, Parana
Irmandade da Santa Casa de Misericordia de Porto Alegre | Hospital Sao Francisco - Centro Medico Pesquisa Clinica Cardiologia, Porto Alegre, Rio Grande Do Sul
Hospital de Clinicas de Porto Alegre | Clinical Research Center - Surgery Research Center, Porto Alegre, Rio Grande Do Sul
Centro de Pesquisas Oncológicas, Florianópolis, Santa Catarina
Faculdade de Ciencias Medicas-Universidade Estadual Campinas, Campinas, Sao Paulo
Centro Multidisciplinar de Estudos Clínicos EPP - Ltda., São Bernardo do Campo, Sao Paulo
IEP São Lucas, São Paulo, Sao Paulo
Instituto Nacional do Cancer Jose Alencar Gomes da Silva, Rio de Janeiro, Not set
Hospital das Clínicas da Faculdade de Medicina da USP, Sao Paulo, Not set
Hospital Israelita Albert Einstein | Morumbi - Clinical Research Department, Sao Paulo, Not set
UMHAT Sveti Georgi, Plovdiv, Not set
University Multiprofile Hosp. for Active Treat. Sveti Ivan, Sofia, Not set
SHATHD Spec. Hospi. for Active Treatm. of Haematol. Dis. EAD, Sofia, Not set
Multiprofile Hospital for Active Treatment Hristo Botev AD, Vratsa, Not set
Hopital Maisonneuve-Rosemont, Montreal, Quebec
Hopital du Sacre-Coeur de Montreal, Montreal, Quebec
Hopital de L'Enfant Jesus, Quebec City, Quebec
Centre Universitaire de Sante de l'Estrie, Sherbrooke, Quebec
Sociedad de Investigaciones Medicas Ltda, Temuco, Araucanía
Centro de Investigaciones Clínicas Vina del Mar Ltda., Vina del Mar, Valparaíso
Instituto Nacional del Cáncer, Santiago, Not set
FuJian Medical University Union Hospital, Fuzhou, Fujian
Guangdong Provincial People's Hospital, Guangzhou, Guangdong
Sun Yat-sen University Cancer Center, Guangzhou, Guangdong
Tumor Hospital of Hebei Province, Hebei, Hebei
Henan Cancer Hospital, Zhengzhou, Henan
Jiangsu Cancer Hospital, Nanjing, Jiangsu
1st Affiliated hospital of Soochow University, Suzhou, Jiangsu
Jilin Cancer Hospital, Changchun, Jilin
The Affiliated Hospital of Qingdao University, Shandong, Shandong
West China Hospital Sichuan University, Chengdu, Sichuan
The 1st Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang
Zhejiang Cancer Hospital, Hangzhou, Zhejiang
Fifth Medical Center, General Hospital of the Chinese People, Beijing, Not set
Beijing Friendship Hospital, Capital Medical University, Beijing, Not set
Fudan University Shanghai Cancer Center, Shanghai, Not set
Xinhua Hos Affiliated to SH Jiaotong Uni School of Medicine, Shanghai, Not set
Tianjin Medical University Cancer Institute & Hospital, Tianjin, Not set
Tianjin Union Medicine Centre (People's Hospital of Tianjin), Tianjin, Not set
Fakultni Nemocnice Hradec Kralove, Hradec Kralove, Not set
Fakultni nemocnice Kralovske Vinohrady, Praha 10, Not set
Rigshospitalet - Hjertesygdomme, København Ø, Not set
Odense Universitetshospital - Hæmatologisk afdeling, Odense C, Not set
HUS, Meilahden sairaala, Helsinki, Not set
Oulun yliopistollinen sairaala, Oulu, Not set
Tampereen yliopistollinen sairaala, Tampere, Not set
Turun yliopistollinen keskussairaala, Turku, Not set
Centre Hospitalier Universitaire - Angers, Angers, Not set
Centre Hospitalier de la Durance - Avignon, Avignon, Not set
Centre Hospitalier Intercommunal de la Côte Basque-Bayonne, Bayonne, Not set
Centre Hospitalier Universite de Grenoble, Grenoble, Not set
Clinique Victor Hugo - Le Mans, Le Mans Cedex 2, Not set
Hôpital Dupuytren, Limoges Cedex, Not set
Hôpital Saint-Eloi, Montpellier Cedex, Not set
Hopital Hotel Dieu - Nantes, Nantes, Not set
Hôpital Saint Louis, Paris, Not set
Centre François Magendie - Pessac, Pessac, Not set
Hôpital de la Milétrie, Poitiers, Not set
Clinique Saint Anne, Strasbourg, Not set
Stauferklinikum Schwäbisch-Gmünd, Mutlangen, Baden-Württemberg
Haematologie-Onkologie im Zentrum MVZ GmbH, Augsburg, Bayern
Klinikum der Universität München Grosshadern, München, Bayern
Medizinische Hochschule Hannover (MHH), Hannover, Niedersachsen
Universitaetsklinikum Muenster, Münster, Nordrhein-Westfalen
Oncologianova GmbH, Recklinghausen, Nordrhein-Westfalen
Marienhospital Herne Universitätsklinik, Herne, NRW
Med. Fakultät der Martin-Luther-Universität Halle-Wittenberg, Halle, Sachsen-Anhalt
EVANGELISMOS General Hospital of Athens, Athens, Not set
General Hospital of Athens LAIKO, Athens, Not set
University General Hospital of Athens "ATTIKON", Chaidari, Not set
Univ. General Hospital of Larissa, Larissa, Not set
University General Hospital of Patras, Patras, Not set
Prince of Wales Hospital, Hong Kong, Not set
Semmelweis University, Budapest, Not set
Orszagos Onkologiai Intezet, Budapest, Not set
Somogy Varmegyei Kaposi Mor Oktato Korhaz, Kaposvar, Not set
Szabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz, Nyiregyhaza, Not set
Pecsi Tudomanyegyetem Klinikai Kozpont, Pecs, Not set
Komarom-Esztergom Varmegyei Szent Borbala Korhaz, Tatabanya, Not set
Cork University Hospital, Cork, Not set
Mater Misericordiae University Hospital, Dublin, Not set
Rambam Health Corporation, Haifa, Not set
Hadassah Hebrew University Hospital Ein Kerem, Jerusalem, Not set
Chaim Sheba Medical Center, Ramat Gan, Not set
Shamir Medical Center (Assaf Harofeh), Zerifin, Not set
IRCCS Ospedale Policlinico San Martino, Genova, Liguria
Humanitas Mirasole S.p.A., Milano, Lombardia
IRCCS Fondazione Policlinico San Matteo, Pavia, Lombardia
A.O.U. Ospedali Riuniti "Umberto I - G.M.Lancisi - G.Salesi", Ancona, Marche
Aichi Cancer Center Hospital, Nagoya, Aichi
Nagoya City University Hospital, Nagoya, Aichi
JCHO Kyushu Hospital, Kitakyushu, Fukuoka
Gunma University Hospital, Maebashi, Gunma
Hyogo Cancer Center, Akashi, Hyogo
Kobe University Hospital, Kobe, Hyogo
Kanagawa Cancer Center, Yokohama, Kanagawa
Tohoku University Hospital, Sendai, Miyagi
Tenri Hospital, Tenri, Nara
Kindai University Hospital, Osakasayama-shi, Osaka
Saitama Medical University International Medical Center, Hidaka, Saitama
National Cancer Center Hospital, Chuo-ku, Tokyo
Aomori Prefectural Central Hospital, Aomori, Not set
National Hospital Organization Kyushu Cancer Center, Fukuoka, Not set
Hiroshima Red Cross & Atomic-bomb Survivors Hospital, Hiroshima, Not set
National Hospital Organization Kumamoto Medical Center, Kumamoto, Not set
Kumamoto University Hospital, Kumamoto, Not set
Osaka Red Cross Hospital, Osaka, Not set
Osaka Metropolitan University Hospital, Osaka, Not set
Yamagata University Hospital, Yamagata, Not set
Seoul National University Hospital, Seoul, Seoul Teugbyeolsi
Severance Hospital, Yonsei University Health System, Seoul, Not set
Asan Medical Center, Seoul, Not set
Samsung Medical Center, Seoul, Not set
Hospital General de México SS, México, D. F., Distrito Federal
Centro de Investigación Clínica Chapultepec S.A. de C.V., Morelia, Michoacán
Hospital Universitario "José Eleuterio González", Monterrey, Nuevo Leon
Centro Especializado en Investigación Clínica S.C., Boca del Río, Veracruz
Centro de Atencion e Investigacion Clinica en Oncologia SCP, Merida, Yucatán
Szpital Morski im. PCK, Gdynia, Not set
Pratia McM Kraków, Krakow, Not set
Wojew. Szpital Specjalistyczny im. M. Kopernika, Lodz, Not set
Centro Clinico Academico Braga | Braga, Portugal, Braga, Not set
Centro Hospitalar Universitario do Porto, Porto, Not set
IPO Porto, Porto, Not set
Centro Hospitalar Vila Nova de Gaia e Espinho | Unit 1 - Clinical Research Center, Porto, Not set
Sp. Judetean de Urgenta Dr. Constantin Opris Baia Mare, Baia Mare, Not set
Sc Onco Card Srl, Brasov, Not set
Spitalul Clinic Colentina, Bucuresti, Not set
Fundeni Clinical Institute, Bucuresti, Not set
Spitalul Clinic Coltea, Bucuresti, Not set
Spitalul Clinic Municipal Filantropia Craiova, Craiova, Not set
Institutul Regional de Oncologie Iasi, Iasi, Not set
Spitalul Clinic Judetean de Urgenta Sibiu, Sibiu, Not set
Kemerovo Regional Clinical Hospital, Kemerovo, Not set
Clinical Oncological Dispensary of Omsk Region, Omsk, Not set
Research Institute of Oncology, Rostov-on-Don, Not set
RSRI of Hematology and Transfusiology, Saint-Petersburg, Not set
Oncology Dispensary #2, Sochi, Not set
Siberian State Medical University, Tomsk, Not set
Republican Clinical Oncology Dispensary, Ufa, Not set
National University Hospital, Singapore, Not set
National Cancer Center Singapore, Singapore, Not set
Singapore General Hospital, Singapore, Not set
Narodny onkologicky ustav, Bratislava, Not set
Outeniqua Cancercare Oncology Unit, George, Eastern Cape
Cancercare Langenhoven, Port Elizabeth, Eastern Cape
Albert Alberts Stem Cell Transplant Research Centre, Pretoria, Gauteng
Constantiaberg Medi Clinic, Cape Town, Western Cape
Institut Català d'Oncologia Badalona, Badalona, Barcelona
Institut Català d'Oncologia Hospitalet, Hospitalet de Llobregat, Barcelona
Hospital Universitario Clinica Puerta de Hierro, Majadahonda, Madrid
Hospital Regional de Malaga | Oncologia, Malaga, Málaga
Ciutat Sanitaria i Universitaria de la Vall d'Hebron, Barcelona, Not set
Hospital Clínico Universitario Lozano Blesa, Zaragoza, Not set
Changhua Christian Hospital, Changhua, Not set
Chang Gung Memorial Hospital Kaohsiung, Kaohsiung, Not set
National Cheng Kung University Hospital, Tainan, Not set
National Taiwan University Hospital, Taipei, Not set
Taipei Veterans General Hospital, Taipei, Not set
Phramongkutklao Hospital, Bangkok, Not set
Siriraj Hospital, Mahidol, Bangkok, Not set
Ankara Universitesi Tip Fakultesi Hastanesi, Ankara, Not set
Trakya Univ. Tip Fak., Edirne, Not set
Istanbul Universitesi Istanbul Tip Fakultesi, Istanbul, Not set
Marmara Uni. Tip Fak. Pendik EAH Hematoloji BD, Istanbul, Not set
Dokuz Eylul Universitesi Tip Fakultesi, Izmir, Not set
Ege Universitesi Tip Fakultesi, Izmir, Not set
Erciyes Universitesi Tip Fakultesi, Kayseri, Not set
Ondokuz Mayis Uni Tip Fakultesi, Samsun, Not set
Karadeniz Teknik Universitesi Tip Fakultesi, Trabzon, Not set
CNE "Clinical Center of Oncology, Hematology, Transplantology and Palliative Care of the Cherkasy Regional Council", Cherkasy, Not set
Municipal Non-Profit Enterprise "City Clinical Hospital ?4" of the Dnipro City Council, Dnipro, Not set
Clinic of National cancer institute - scientific and research department of pediatric oncology, Kyiv, Not set
State Institution - Institute of Blood Pathology and Transfusion Medicine NAMS of Ukraine, Lviv, Not set
CNE "Zaporizhzhia Regional Clinical Hospital" of Zaporizhzhia regional council, Zaporizhzhya, Not set
Royal Devon & Exeter Hospital, Exeter, Devon
Northwick Park Hospital, Harrow, London
St George's Hospital, Kogarah, London
Dorset County Hospital, Dorchester, Not set
Royal Marsden Hospital (London), London, Not set
Singleton Hospital, Swansea, Not set
Conditions: Lymphoma, Non-Hodgkin
Optimizing Lymphodepletion to Improve Outcomes in Patients Receiving Cell Therapy With Kymriah
Withdrawn
This is a Phase 1b study of participants with Diffuse Large B Cell Lymphoma (DLBCL). The purpose of this study is to identify an optimized lymphodepletion (LD) regimen by evaluating standard and intermediate doses of Fludarabine (Flu) / Cyclophosphamide (Cy) with or without a fixed dose of total lymphoid irradiation (TLI) in the setting of standard of care chimeric antigen receptor T (CAR T) cell therapy.
This is a Phase 1b study of participants with Diffuse Large B Cell Lymphoma (DLBCL). The purpose of this study is to identify an optimized lymphodepletion (LD) regimen by evaluating standard and intermediate doses of Fludarabine (Flu) / Cyclophosphamide (Cy) with or without a fixed dose of total lymphoid irradiation (TLI) in the setting of standard of care chimeric antigen receptor T (CAR T) cell therapy. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/09/2024
Locations: Princess Margaret Cancer Centre, Toronto, Ontario
Princess Margaret Cancer Centre, Toronto, Ontario
Conditions: Lymphoma, Large B-Cell, Diffuse
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