All Clinical Trials in Canada

A listing of 3894 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.

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An Open-label Study to Assess Safety and Efficacy of SZC in Paediatric Patients With Hyperkalaemia

NCT03813407

Recruiting

Sodium zirconium cyclosilicate has been shown to be effective and safe in adults for the treatment of hyperkalaemia, and therefore it is expected to be beneficial in children. This study will evaluate the efficacy, safety and tolerability of sodium zirconium cyclosilicate for the treatment of hyperkalaemia in children \<18 years of age. Approximately 140 participants will enter CP at approximately 46 sites in locations including but not limited to Europe and North America for this study. Treatment will include 3 phases: the CP, MP, and LTMP. Enrolment will start in 2 cohorts, ages 6 to \< 12 years and 12 to \< 18 years. After review of accumulated data, the independent Data Monitoring Committee (iDMC) will recommend whether to open enrolment in the ages 2 to \< 6 years cohort and later in the ages 0 to \< 2 years cohort. All eligible participants with hyperkalaemia will enter an open-label Correction Phase (CP) receiving a fixed dose of SZC three times daily (TID) for up to 3 days until normokalaemia is achieved. Within each age cohorts 2 to \< 18 years, initial participants will be allocated to the dose level (DL) based on body weight equivalent to an adult 5 g TID. After recommendation of higher DLs by the iDMC, subsequent participants may be allocated in the CP to on body weight equivalent to an adult 10 g TID and then potentially on body weight equivalent to an adult 15 g TID. All participants in the ages 0 to \< 2 years cohort will be assigned to the same DL which will be decided based on data from older age cohorts. Participants who successfully achieve normokalaemia in the CP will enter a 28-day open-label Maintenance Phase (MP), which will be initiated with once daily administration of the dose received TID in the CP. During MP, the Investigator is able to titrate the dose up or down in the range 2.5 g to 15 g body weight equivalent to maintain normokalaemia. For participants who, at the end of MP, are normokalaemic or hyperkalaemic without being on maximum dose, the MP is followed by the option to continue the study in a long term maintenance phase (LTMP) where the same titration regimen is used as in MP Read Less

Gender:

ALL

Ages:

Between 0 years and 18 years

Trial Updated:

07/17/2025

Locations: Research Site, Birmingham, Alabama +68 locations

Research Site, Birmingham, Alabama

Research Site, Atlanta, Georgia

Research Site, Baltimore, Maryland

Research Site, Grand Rapids, Michigan

Research Site, Saint Louis, Missouri

Research Site, Hackensack, New Jersey

Research Site, New York, New York

Research Site, Stony Brook, New York

Research Site, Charlotte, North Carolina

Research Site, Winston-Salem, North Carolina

Research Site, Akron, Ohio

Research Site, Cincinnati, Ohio

Research Site, Columbia, South Carolina

Research Site, Morgantown, West Virginia

Research Site, Campinas, Not set

Research Site, Sao Paulo, Not set

Research Site, Calgary, Alberta

Research Site, Edmonton, Alberta

Research Site, Vancouver, British Columbia

Research Site, Montreal, Quebec

Research Site, Beijing, Not set

Research Site, Changsha, Not set

Research Site, Chengdu, Not set

Research Site, Chongqing, Not set

Research Site, Hangzhou, Not set

Research Site, Hefei, Not set

Research Site, Shanghai, Not set

Research Site, Berlin, Not set

Research Site, Essen, Not set

Research Site, Heidelberg, Not set

Research Site, Bhubaneshwar, Not set

Research Site, Gurgaon, Not set

Research Site, New Delhi, Not set

Research Site, Bunkyo-ku, Not set

Research Site, Fuchu-shi, Not set

Research Site, Fukuoka-shi, Not set

Research Site, Kawasaki-shi, Not set

Research Site, Kobe-shi, Not set

Research Site, Matsumoto-shi, Not set

Research Site, Nakagami-gun, Not set

Research Site, Saitama-Shi, Not set

Research Site, Sendai-Shi, Not set

Research Site, Shizuoka-Shi, Not set

Research Site, Białystok, Not set

Research Site, Krakow, Not set

Research Site, Warszawa, Not set

Research Site, Łódź, Not set

Research Site, Bucuresti, Not set

Research Site, București, Not set

Research Site, Cluj-Napoca, Not set

Research Site, Targu Mures, Not set

Research Site, Timisoara, Not set

Research Site, Samara, Not set

Research Site, Esplugues de Llobregat, Not set

Research Site, Madrid, Not set

Research Site, Dnipropetrovsk, Not set

Research Site, Kharkiv Region, Not set

Research Site, Kyiv, Not set

Research Site, Odesa, Not set

Research Site, Sumy, Not set

Research Site, Zaporizhzhia, Not set

Research Site, Glasgow, Not set

Research Site, Hampshire, Not set

Research Site, Manchester, Not set

Research Site, Nottingham, Not set

Conditions: Hyperkalaemia

Learn More ›

A Study of Nipocalimab in Pregnancies at Risk for Severe Hemolytic Disease of the Fetus and Newborn (HDFN)

NCT05912517

Recruiting

The purpose of this study is to assess the effectiveness of nipocalimab when compared to placebo in decreasing the risk of fetal anemia (a condition in which a baby's red blood cell volume falls below normal levels while the baby is developing in the womb) with live neonates in pregnant participants at risk for severe hemolytic disease of the fetus and newborn.

Gender:

FEMALE

Ages:

Between 18 years and 45 years

Trial Updated:

07/17/2025

Locations: UC Davis School of Medicine, Sacramento, California +52 locations

UC Davis School of Medicine, Sacramento, California

Childrens Hospital Colorado, Aurora, Colorado

Advocate Children's Hospital, Park Ridge, Illinois

Riley Children s Hospital, Indianapolis, Indiana

University of Kentucky Medical Center, Lexington, Kentucky

Johns Hopkins Hospital, Baltimore, Maryland

Midwest Fetal Care Center, Minneapolis, Minnesota

Columbia University Medical Center, New York, New York

University of North Carolina (UNC) - School of Medicine, Chapel Hill, North Carolina

University of Cincinnati, Cincinnati, Ohio

Oregon Health and Science University, Portland, Oregon

Lehigh Valley Hospital, Allentown, Pennsylvania

University of Texas Dell Medical School Department of Women's Health, Austin, Texas

University Of Texas Medical Branch At Galveston, Galveston, Texas

Eastern Virginia Medical School, Norfolk, Virginia

Hospital Italiano de Buenos Aires, Buenos Aires, Not set

Hospital Privado Universitario De Cordoba, Cordoba, Not set

Mater Hospital Brisbane, South Brisbane, Not set

Liverpool Hospital, Sydney, Not set

Medizinische Universitaet Wien, Vienna, Not set

C.H.U. Brugmann, Bruxelles, Not set

Universitair Ziekenhuis Leuven, Leuven, Not set

Universidade Federal De Minas Gerais, Belo Horizonte, Not set

Empresa Brasileira de Servicos Hospitalares EBSERH Hospital das Clinicas da UFG, Goiania, Not set

Instituto de Medicina Integral Professor Fernando Figueira, Recife, Not set

Instituto D Or de Pesquisa e Ensino IDOR, Rio de Janeiro, Not set

Hospital Das Clinicas Da Faculdade De Medicina Da USP, Sao Paulo, Not set

BC Women's Hospital University of British Columbia, Vancouver, British Columbia

Centre Hospitalier Sainte Justine, Montreal, Quebec

McGill University Health Centre, Montreal, Quebec

CHRU Lille, Lille Cedex, Not set

Hopital Armand Trousseau, Paris, Not set

Charite Universitaetsmedizin Berlin, Berlin, Not set

Universitaetsklinikum Giessen und Marburg Standort Giessen, Giessen, Not set

Rotunda Hospital, Dublin, Not set

Rabin Medical Center, Petah Tikva, Not set

The Chaim Sheba Medical Center, Ramat Gan, Not set

Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Not set

Kyushu University Hospital, Fukuoka, Not set

Gifu Prefectural General Medical Center, Gifu, Not set

Osaka Women's and Children's Hospital, Izumi-shi, Not set

Toho University Medical Center Omori Hospital, Ota, Not set

Miyagi Children's Hospital, Sendai, Not set

Leiden University Medical Center, Leiden, Not set

Hosp Univ Vall D Hebron, Barcelona, Not set

Hosp. Univ. La Paz, Madrid, Not set

Hosp. Virgen Del Rocio, Sevilla, Not set

Karolinska Universitetssjukhuset Huddinge, Stockholm, Not set

Birmingham Women's Hospital, Birmingham, Not set

Leeds Teaching Hospitals NHS Trust, Leeds, Not set

St Georges Hospital, London, Not set

St.Mary's Hospital, Manchester, Not set

John Radcliffe Hospital, Oxford, Not set

Conditions: Hemolytic Disease of the Fetus and Newborn

Learn More ›

Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma

NCT06172296

Recruiting

This phase III trial tests how well the addition of dinutuximab to Induction chemotherapy along with standard of care surgical resection of the primary tumor, radiation, stem cell transplantation, and immunotherapy works for treating children with newly diagnosed high-risk neuroblastoma. Dinutuximab is a monoclonal antibody that binds to a molecule called GD2, which is found on the surface of neuroblastoma cells, but is not present on many healthy or normal cells in the body. When dinutuximab binds to the neuroblastoma cells, it helps signal the immune system to kill the tumor cells. This helps the cells of the immune system kill the cancer cells, this is a type of immunotherapy. When chemotherapy and immunotherapy are given together, during the same treatment cycle, it is called chemoimmunotherapy. This clinical trial randomly assigns patients to receive either standard chemotherapy and surgery or chemoimmunotherapy (chemotherapy plus dinutuximab) and surgery during Induction therapy. Chemotherapy drugs administered during Induction include, cyclophosphamide, topotecan, cisplatin, etoposide, vincristine, and doxorubicin. These drugs work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing or by stopping them from spreading. Upon completion of 5 cycles of Induction therapy, a disease evaluation is completed to determine how well the treatment worked. If the tumor responds to therapy, patients receive a tandem transplantation with stem cell rescue. If the tumor has little improvement or worsens, patients receive chemoimmunotherapy on Extended Induction. During Extended Induction, dinutuximab is given with irinotecan, temozolomide. Patients with a good response to therapy move on to Consolidation therapy, when very high doses of chemotherapy are given at two separate points to kill any remaining cancer cells. Following, transplant, radiation therapy is given to the site where the cancer originated (primary site) and to any other areas that are still active at the end of Induction. The final stage of therapy is Post-Consolidation. During Post-Consolidation, dinutuximab is given with isotretinoin, with the goal of maintaining the response achieved with the previous therapy. Adding dinutuximab to Induction chemotherapy along with standard of care surgical resection of the primary tumor, radiation, stem cell transplantation, and immunotherapy may be better at treating children with newly diagnosed high-risk neuroblastoma. Read Less

Gender:

ALL

Ages:

30 years and below

Trial Updated:

07/17/2025

Locations: Children's Hospital of Alabama, Birmingham, Alabama +157 locations

Children's Hospital of Alabama, Birmingham, Alabama

USA Health Strada Patient Care Center, Mobile, Alabama

Banner Children's at Desert, Mesa, Arizona

Phoenix Childrens Hospital, Phoenix, Arizona

Banner University Medical Center - Tucson, Tucson, Arizona

Arkansas Children's Hospital, Little Rock, Arkansas

Kaiser Permanente Downey Medical Center, Downey, California

City of Hope Comprehensive Cancer Center, Duarte, California

Loma Linda University Medical Center, Loma Linda, California

Miller Children's and Women's Hospital Long Beach, Long Beach, California

Children's Hospital Los Angeles, Los Angeles, California

Cedars Sinai Medical Center, Los Angeles, California

Mattel Children's Hospital UCLA, Los Angeles, California

Valley Children's Hospital, Madera, California

UCSF Benioff Children's Hospital Oakland, Oakland, California

Kaiser Permanente-Oakland, Oakland, California

Children's Hospital of Orange County, Orange, California

Lucile Packard Children's Hospital Stanford University, Palo Alto, California

University of California Davis Comprehensive Cancer Center, Sacramento, California

UCSF Medical Center-Mission Bay, San Francisco, California

Children's Hospital Colorado, Aurora, Colorado

Connecticut Children's Medical Center, Hartford, Connecticut

Yale University, New Haven, Connecticut

Alfred I duPont Hospital for Children, Wilmington, Delaware

Children's National Medical Center, Washington, District of Columbia

Broward Health Medical Center, Fort Lauderdale, Florida

Golisano Children's Hospital of Southwest Florida, Fort Myers, Florida

University of Florida Health Science Center - Gainesville, Gainesville, Florida

Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood, Florida

Nemours Children's Clinic-Jacksonville, Jacksonville, Florida

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida

Nicklaus Children's Hospital, Miami, Florida

AdventHealth Orlando, Orlando, Florida

Arnold Palmer Hospital for Children, Orlando, Florida

Nemours Children's Hospital, Orlando, Florida

Johns Hopkins All Children's Hospital, Saint Petersburg, Florida

Saint Mary's Medical Center, West Palm Beach, Florida

Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia

Lurie Children's Hospital-Chicago, Chicago, Illinois

University of Illinois, Chicago, Illinois

University of Chicago Comprehensive Cancer Center, Chicago, Illinois

Advocate Children's Hospital-Oak Lawn, Oak Lawn, Illinois

Advocate Children's Hospital-Park Ridge, Park Ridge, Illinois

Saint Jude Midwest Affiliate, Peoria, Illinois

Southern Illinois University School of Medicine, Springfield, Illinois

Riley Hospital for Children, Indianapolis, Indiana

Blank Children's Hospital, Des Moines, Iowa

University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa

Wesley Medical Center, Wichita, Kansas

University of Kentucky/Markey Cancer Center, Lexington, Kentucky

Children's Hospital New Orleans, New Orleans, Louisiana

Eastern Maine Medical Center, Bangor, Maine

Maine Children's Cancer Program, Scarborough, Maine

University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland

Sinai Hospital of Baltimore, Baltimore, Maryland

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland

Dana-Farber Cancer Institute, Boston, Massachusetts

C S Mott Children's Hospital, Ann Arbor, Michigan

Children's Hospital of Michigan, Detroit, Michigan

Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids, Michigan

Bronson Methodist Hospital, Kalamazoo, Michigan

Corewell Health Children's, Royal Oak, Michigan

Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis, Minnesota

University of Minnesota/Masonic Cancer Center, Minneapolis, Minnesota

Mayo Clinic in Rochester, Rochester, Minnesota

University of Mississippi Medical Center, Jackson, Mississippi

Children's Mercy Hospitals and Clinics, Kansas City, Missouri

Washington University School of Medicine, Saint Louis, Missouri

Mercy Hospital Saint Louis, Saint Louis, Missouri

Children's Hospital and Medical Center of Omaha, Omaha, Nebraska

University of Nebraska Medical Center, Omaha, Nebraska

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire

Hackensack University Medical Center, Hackensack, New Jersey

Morristown Medical Center, Morristown, New Jersey

Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick, New Jersey

Saint Joseph's Regional Medical Center, Paterson, New Jersey

Albany Medical Center, Albany, New York

Montefiore Medical Center - Moses Campus, Bronx, New York

Roswell Park Cancer Institute, Buffalo, New York

NYU Langone Hospital - Long Island, Mineola, New York

The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, New York

Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York

University of Rochester, Rochester, New York

New York Medical College, Valhalla, New York

Mission Hospital, Asheville, North Carolina

UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina

Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina

Novant Health Presbyterian Medical Center, Charlotte, North Carolina

Duke University Medical Center, Durham, North Carolina

East Carolina University, Greenville, North Carolina

Wake Forest University Health Sciences, Winston-Salem, North Carolina

Sanford Broadway Medical Center, Fargo, North Dakota

Children's Hospital Medical Center of Akron, Akron, Ohio

Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio

Rainbow Babies and Childrens Hospital, Cleveland, Ohio

Cleveland Clinic Foundation, Cleveland, Ohio

Nationwide Children's Hospital, Columbus, Ohio

Dayton Children's Hospital, Dayton, Ohio

ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo, Ohio

University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

Legacy Emanuel Children's Hospital, Portland, Oregon

Oregon Health and Science University, Portland, Oregon

Geisinger Medical Center, Danville, Pennsylvania

Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

Saint Christopher's Hospital for Children, Philadelphia, Pennsylvania

Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania

Rhode Island Hospital, Providence, Rhode Island

Medical University of South Carolina, Charleston, South Carolina

Prisma Health Richland Hospital, Columbia, South Carolina

BI-LO Charities Children's Cancer Center, Greenville, South Carolina

Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota

East Tennessee Childrens Hospital, Knoxville, Tennessee

Saint Jude Children's Research Hospital, Memphis, Tennessee

The Children's Hospital at TriStar Centennial, Nashville, Tennessee

Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee

Dell Children's Medical Center of Central Texas, Austin, Texas

Driscoll Children's Hospital, Corpus Christi, Texas

Medical City Dallas Hospital, Dallas, Texas

UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas

El Paso Children's Hospital, El Paso, Texas

Cook Children's Medical Center, Fort Worth, Texas

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas

M D Anderson Cancer Center, Houston, Texas

Covenant Children's Hospital, Lubbock, Texas

UMC Cancer Center / UMC Health System, Lubbock, Texas

Children's Hospital of San Antonio, San Antonio, Texas

Methodist Children's Hospital of South Texas, San Antonio, Texas

University of Texas Health Science Center at San Antonio, San Antonio, Texas

Primary Children's Hospital, Salt Lake City, Utah

University of Virginia Cancer Center, Charlottesville, Virginia

Naval Medical Center - Portsmouth, Portsmouth, Virginia

Seattle Children's Hospital, Seattle, Washington

Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington

Mary Bridge Children's Hospital and Health Center, Tacoma, Washington

University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin

Marshfield Medical Center-Marshfield, Marshfield, Wisconsin

Children's Hospital of Wisconsin, Milwaukee, Wisconsin

Sydney Children's Hospital, Randwick, New South Wales

The Children's Hospital at Westmead, Westmead, New South Wales

Queensland Children's Hospital, South Brisbane, Queensland

Royal Children's Hospital, Parkville, Victoria

Perth Children's Hospital, Perth, Western Australia

Alberta Children's Hospital, Calgary, Alberta

University of Alberta Hospital, Edmonton, Alberta

British Columbia Children's Hospital, Vancouver, British Columbia

CancerCare Manitoba, Winnipeg, Manitoba

IWK Health Centre, Halifax, Nova Scotia

McMaster Children's Hospital at Hamilton Health Sciences, Hamilton, Ontario

Children's Hospital, London, Ontario

Children's Hospital of Eastern Ontario, Ottawa, Ontario

Hospital for Sick Children, Toronto, Ontario

The Montreal Children's Hospital of the MUHC, Montreal, Quebec

Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec

Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke, Quebec

Jim Pattison Children's Hospital, Saskatoon, Saskatchewan

CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Quebec, Not set

Starship Children's Hospital, Grafton, Auckland

Conditions: Neuroblastoma, Ganglioneuroblastoma, Nodular

Learn More ›

A Study of JNJ-89853413 for Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Neoplasms

NCT06618001

Recruiting

The purpose of Part 1 (Dose Escalation) of the study is to assess the safety and tolerability, and to identify the recommended Phase 2 dose\[s\] (RP2D\[s\]) in participants with relapsed or refractory (R/R) acute myeloid leukemia (AML) (that is a type of blood cancer that has come back after treatment/or has stopped responding to treatment) or R/R higher-risk type of myelodysplastic neoplasms (MDS, type of blood cancer). The purpose of Part 2 (Cohort Expansion) is to further assess the safety, t... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/17/2025

Locations: Vancouver General Hospital, Vancouver, British Columbia +6 locations

Conditions: Leukemia, Myeloid, Acute, Myelodysplastic Neoplasms

Learn More ›

A Study Using Nivolumab, in Combination With Chemotherapy Drugs to Treat Nasopharyngeal Carcinoma (NPC)

NCT06064097

Recruiting

This phase II trial tests effects of nivolumab in combination with chemotherapy drugs prior to radiation therapy patients with nasopharyngeal carcinoma (NPC). Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs, such as gemcitabine and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping the... Read More

Gender:

ALL

Ages:

21 years and below

Trial Updated:

07/17/2025

Locations: Children's Hospital of Alabama, Birmingham, Alabama +57 locations

Children's Hospital of Alabama, Birmingham, Alabama

Arkansas Children's Hospital, Little Rock, Arkansas

Kaiser Permanente Downey Medical Center, Downey, California

Loma Linda University Medical Center, Loma Linda, California

Valley Children's Hospital, Madera, California

UCSF Benioff Children's Hospital Oakland, Oakland, California

Kaiser Permanente-Oakland, Oakland, California

Rady Children's Hospital - San Diego, San Diego, California

UCSF Medical Center-Mission Bay, San Francisco, California

Children's Hospital Colorado, Aurora, Colorado

Alfred I duPont Hospital for Children, Wilmington, Delaware

Children's National Medical Center, Washington, District of Columbia

University of Florida Health Science Center - Gainesville, Gainesville, Florida

Nemours Children's Clinic-Jacksonville, Jacksonville, Florida

Nicklaus Children's Hospital, Miami, Florida

Arnold Palmer Hospital for Children, Orlando, Florida

Nemours Children's Hospital, Orlando, Florida

Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa, Florida

Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia

Lurie Children's Hospital-Chicago, Chicago, Illinois

Riley Hospital for Children, Indianapolis, Indiana

Children's Hospital New Orleans, New Orleans, Louisiana

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland

Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids, Michigan

Mayo Clinic in Rochester, Rochester, Minnesota

University of Mississippi Medical Center, Jackson, Mississippi

Children's Mercy Hospitals and Clinics, Kansas City, Missouri

Washington University School of Medicine, Saint Louis, Missouri

Children's Hospital and Medical Center of Omaha, Omaha, Nebraska

University of Nebraska Medical Center, Omaha, Nebraska

Hackensack University Medical Center, Hackensack, New Jersey

Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick, New Jersey

Newark Beth Israel Medical Center, Newark, New Jersey

Albany Medical Center, Albany, New York

Sanford Broadway Medical Center, Fargo, North Dakota

Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio

Rainbow Babies and Childrens Hospital, Cleveland, Ohio

Nationwide Children's Hospital, Columbus, Ohio

University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

Penn State Children's Hospital, Hershey, Pennsylvania

Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania

Prisma Health Richland Hospital, Columbia, South Carolina

Saint Jude Children's Research Hospital, Memphis, Tennessee

The Children's Hospital at TriStar Centennial, Nashville, Tennessee

Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee

Dell Children's Medical Center of Central Texas, Austin, Texas

UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas

Cook Children's Medical Center, Fort Worth, Texas

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas

M D Anderson Cancer Center, Houston, Texas

Children's Hospital of San Antonio, San Antonio, Texas

University of Virginia Cancer Center, Charlottesville, Virginia

Children's Hospital of The King's Daughters, Norfolk, Virginia

Virginia Commonwealth University/Massey Cancer Center, Richmond, Virginia

Seattle Children's Hospital, Seattle, Washington

Mary Bridge Children's Hospital and Health Center, Tacoma, Washington

Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec

Conditions: Stage II Nasopharyngeal Carcinoma AJCC v8, Stage III Nasopharyngeal Carcinoma AJCC v8, Stage IV Nasopharyngeal Carcinoma AJCC v8

Learn More ›

A Study in Participants With Major Depressive Disorder (MDD) With Anhedonia and Inadequate Response to Current Antidepressant Therapy Including a Selective Serotonin Reuptake Inhibitor (SSRI) or Serotonin Norepinephrine Reuptake Inhibitor (SNRI)

NCT05841030

Recruiting

The purpose of this study is to assess the socio-demographic, disease-related and treatment-related characteristics, and the standard of care (SOC) treatment patterns of participants with major depressive disorder (MDD) with anhedonia with inadequate response to their current antidepressant treatments and treated according to the standard of care treatment.

Gender:

ALL

Ages:

Between 18 years and 74 years

Trial Updated:

07/17/2025

Locations: University of Alabama at Birmingham, Birmingham, Alabama +92 locations

University of Alabama at Birmingham, Birmingham, Alabama

University of Alabama at Birmingham, Homewood, Alabama

ATP Clinical Research, California City, California

University of Connecticut Health Center, Farmington, Connecticut

Flagler Hospital and Florida Center for TMS, Saint Augustine, Florida

Center for Revitalizing Psychiatry, Sarasota, Florida

Interventional Psychiatry of Tampa Bay, Tampa, Florida

Atlanta Behavioral Research, LLC, Atlanta, Georgia

Psych Atlanta, P.C., Marietta, Georgia

University of Chicago, Chicago, Illinois

Loyola University Medical Center, Maywood, Illinois

Baber Research Group, Naperville, Illinois

Lumin Health, Newton, Massachusetts

Univeristy of Massachusetts, Worcester, Massachusetts

Missouri University Health Care South Providence Psychiatry, Columbia, Missouri

Signature Research Associates Inc., Fairlawn, Ohio

Lehigh Center for Clinical Research, Allentown, Pennsylvania

Seattle Neuropsychiatric Treatment Center, Tacoma, Washington

Hospital Fleni, Ciudad Autonoma Buenos Aires, Not set

Fundacion para el Estudio y Tratamiento de las Enfermedades Mentales, Ciudad Autonoma de Buenos Aires, Not set

Hospital Italiano de Buenos Aires, Ciudad Autonoma de Buenos Aires, Not set

Resolution, Ciudad de Mendoza, Not set

CEN Consultorios Especializados en Neurociencias, Cordoba, Not set

Instituto Medico DAMIC, Cordoba, Not set

Centro Medico Luquez, Cordoba, Not set

Hospital Sao Vicente de Paulo, Passo Fundo, Not set

Centro Integrado Facili, Sao Bernardo do Campo, Not set

Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto Hospital de Base, Sao Jose Rio Preto, Not set

Clinica Viver - Centro de Desospitalizacao Humana, Sao Paulo, Not set

Hospital Das Clinicas Da Faculdade De Medicina Da USP, Sao Paulo, Not set

The Medical Arts Health Research Group, West Vancouver, British Columbia

Providence Care Hospital, Kingston, Ontario

St. Michael's Hospital, Toronto, Ontario

Jodha Tishon Inc., Toronto, Ontario

Introspect Clinic, Ontario, Not set

CHU Angers - Hopital Hotel Dieu, Angers, Not set

CHU Clermont-Ferrand - Hopital Gabriel Montpied, Clermont Ferrand, Not set

Cabinet Medical des Drs Prizac-Desbonnet Scottez, Douai, Not set

Hopital la Colombiere, Montpellier Cedex 5, Not set

CHU de Nantes hotel Dieu, Nantes, Not set

Cabinet De Psychiatrie Neurostim, Paris, Not set

Groupe Hospitalier Pitie-Salpetriere, Paris, Not set

Universitaetsklinikum der RWTH Aachen, Aachen, Not set

Praxis Dr. med. Kirsten Hahn, Berlin, Not set

Vivantes Klinikum Spandau, Berlin, Not set

Universitaetsklinikum Frankfurt, Frankfurt, Not set

Universitatsklinikum Jena, Jena, Not set

Universitatsmedizin der Johannes Gutenberg Universitat Mainz, Mainz, Not set

Pharmakologisches Studienzentrum Chemnitz GmbH, Mittweida, Not set

Gemeinschaftspraxis Prof. Steinbach und Dr. Steib, Nuernberg, Not set

Praxis Kuehn, Oranienburg, Not set

Praxis Dipl.-med. Stefan Kusserow, Stralsund, Not set

ASL ROMA, Colleferro, Not set

Ospedale Policlinico San Martino IRCCS, Genova, Not set

AUSL LE di Lecce, Lecce, Not set

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Pad. Marcora, Milano, Not set

Ospedale San Raffaele, Milano, Not set

Azienda Ospedaliero Universitaria di Parma, Parma, Not set

Universita degli Studi di Perugia, Perugia, Not set

Policlinico Tor Vergata, Roma, Not set

University of Siena, Siena, Not set

Kyungpook National University Hospital, Daegu, Not set

CHA University ilsan Medical Center, Goyang, Not set

Gachon University Gil Medical Center, Incheon, Not set

Jeju National University Hospital, Jeju Special, Not set

Kangbuk Samsung Hospital, Seoul, Not set

Hallym University Kangdong Sacred Heart Hospital, Seoul, Not set

Gangnam Severance Hospital, Yonsei University Health System, Seoul, Not set

Samsung Medical Center, Seoul, Not set

Hosp. de La Santa Creu I Sant Pau, Barcelona, Not set

Hosp Clinic de Barcelona, Barcelona, Not set

Hosp. Gral. de Villalba, Collado Villalba, Not set

Hosp. de Jerez de La Frontera, Jerez de la Frontera, Not set

Hosp. Univ. Infanta Leonor, Madrid, Not set

Csm Fuencarral, Madrid, Not set

Hosp Regional Univ de Malaga, Málaga, Not set

Hosp. El Bierzo, Ponferrada, Not set

Hosp. Univ. I Politecni La Fe, Valencia, Not set

Hosp. Prov. de Zamora, Zamora, Not set

Gustavsbergs Vardcentral, Gustavsberg, Not set

Affecta Pskyiatrimottagning, Halmstad, Not set

ProbarE i Lund AB, Lund, Not set

ONE LIFETIME Lakarmottagning, Skovde, Not set

Abraham Cowley Unit, Chertsey, Not set

Kingsway Hospital, Derby, Not set

Wonford House Hospital, Exeter, Not set

Kings College Hospital, London, Not set

Greater Manchester Mental Health NHSFT, Manchester, Not set

Cumbria, Northumberland, Tyne and Wear NHS Foundation Trust, Newcastle upon Tyne, Not set

Lincolnshire Partnership NHS Foundation Trust (LPFT), Sleaford, Not set

Moorgreen Hospital, Southampton, Not set

St George's Hospital, Stafford, Not set

South West Yorkshire Trust, Wakefield, Not set

Conditions: Depressive Disorder, Major

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A Study of Daratumumab-Based Therapies in Participants With Amyloid Light Chain (AL) Amyloidosis

NCT05250973

Recruiting

The purpose of this study is to characterize cardiac safety of Daratumumab, Cyclophosphamide, Bortezomib, and Dexamethasone (D-VCd) treatment regimens (Arm A: daratumumab + immediate VCd treatment and Arm B: daratumumab + deferred VCd) in newly diagnosed systemic amyloid light chain (AL) amyloidosis with cardiac involvement and to identify potential mitigation strategies for cardiac toxicity (cohort 1); to characterize the pharmacokinetics of subcutaneous (SC) daratumumab, among racial and ethni... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/17/2025

Locations: City of Hope, Duarte, California +45 locations

City of Hope, Duarte, California

Smilow Cancer Hospital/Yale Cancer Center, New Haven, Connecticut

Moffitt Cancer Center, Tampa, Florida

Winship Cancer Institute Emory University, Atlanta, Georgia

Tufts Medical Center, Boston, Massachusetts

Boston University Medical Center, Boston, Massachusetts

Barbara Ann Karmanos Cancer Institute, Detroit, Michigan

Memorial Sloan Kettering, New York, New York

Levine Cancer Institute, Charlotte, North Carolina

Wake Forest University - Baptist Medical Center, Winston-Salem, North Carolina

University Hospital of Cleveland, Cleveland, Ohio

Ohio Health Research Institute, Columbus, Ohio

West Penn Hospital, Pittsburgh, Pennsylvania

UT Southwestern Medical Center, Dallas, Texas

VCU Medical Center, Richmond, Virginia

University of Washington, Seattle, Washington

Tom Baker Cancer Center, Calgary, Alberta

Cross Cancer Institute, Edmonton, Alberta

University Health Network UHN Princess Margaret Cancer Centre, Toronto, Ontario

Peking University First Hospital, Beijing, Not set

Peking University People s Hospital, Beijing, Not set

West China Hospital Si Chuan University, Chengdu, Not set

First affiliated Hospital of Zhejiang University, Hangzhou, Not set

Ruijin Hospital Shanghai Jiao Tong University, Shanghai, Not set

CHU de Limoges, Limoges Cedex, Not set

Centre hospitalier Lyon-Sud, Pierre Benite cedex, Not set

CHU De Poitiers, Poitiers, Not set

CHU Rangueil, Toulouse, Not set

Charite Campus Benjamin Franklin, Berlin, Not set

Universitatsklinikum Essen, Essen, Not set

Universitaetsklinikum Heidelberg Medizinische Klinik V, Heidelberg, Not set

Alexandra General Hospital of Athens, Athens, Not set

Università Degli Studi Di Napoli Federico Ii, Napoli, Not set

Fondazione IRCCS Policlinico San Matteo, Pavia, Not set

DIPARTIMENTO DI BIOTECNOLOGIE CELLULARI ED EMATOLOGIA - UNIVERSITà ''LA SAPIENZA'', Roma, Not set

University Medical Center Groningen, Groningen, Not set

Hospital Maastricht University Medical Center, Maastricht, Not set

UMC Utrecht, Utrecht, Not set

Hosp. Univ. Germans Trias I Pujol, Badalona, Not set

Hosp Univ Vall D Hebron, Barcelona, Not set

Hosp Clinic de Barcelona, Barcelona, Not set

Clinica Univ. de Navarra, Madrid, Not set

Clinica Univ. de Navarra, Pamplona, Not set

Hosp Clinico Univ de Salamanca, Salamanca, Not set

Leicester Royal Infirmary - Haematology, Leicester, Not set

University College Hospital, London, Not set

Conditions: Amyloidosis

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A Study of Guselkumab in Participants With Fistulizing, Perianal Crohn's Disease

NCT05347095

Recruiting

The purpose of this study to evaluate the clinical efficacy of guselkumab in fistulizing, perianal Crohn's disease and to assess the overall safety of guselkumab.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/17/2025

Locations: University of Alabama at Birmingham, Birmingham, Alabama +152 locations

University of Alabama at Birmingham, Birmingham, Alabama

Yale University, New Haven, Connecticut

University of Miami, Miami, Florida

Gastroenterology Group Of Naples, Naples, Florida

AdventHealth Medical Group Blood & Marrow Transplant at Orlando, Orlando, Florida

Kansas University Medical Center, Kansas City, Kansas

University of Kentucky Chandler Medical Center, Lexington, Kentucky

University of Louisville, Louisville, Kentucky

Washington University School Of Medicine, Saint Louis, Missouri

Mount Sinai School of Medicine, New York, New York

Digestive Disease Specialists Inc, Oklahoma City, Oklahoma

Gastro One, Germantown, Tennessee

Vanderbilt University Medical Center, Nashville, Tennessee

Tyler Research Institute, LLC, Tyler, Texas

Swedish Medical Center, Seattle, Washington

Flinders Medical Centre, Adelaide, Not set

St Vincent's Hospital - Melbourne, Fitzroy, Not set

Liverpool Hospital, Liverpool, Not set

Fiona Stanley Hospital, Murdoch, Not set

Royal Prince Alfred Hospital, Newtown, Not set

Royal Adelaide Hospital, North Terrace, Not set

Royal Melbourne Hospital, Parkville, Not set

Royal Perth Hospital, Perth, Not set

Mater Hospital, South Brisbane, Not set

Hopital Erasme, Bruxelles, Not set

Ziekenhuis Oost-Limburg, Genk, Not set

UZ Leuven, Leuven, Not set

CHU Sart Tilman, Liege, Not set

University of Alberta- Ziedler Ledcor Centre, Edmonton, Alberta

Nova Scotia Health Authority, Halifax, Nova Scotia

London Health Sciences Centre, London, Ontario

Mount Sinai Hospital, Toronto, Ontario

McGill University Health Centre, Montreal, Quebec

Nemocnice Ceske Budejovice a s, Ceske Budejovice, Not set

ISCARE a.s., Praha 9, Not set

Alexandria University Hospital, Alexandria, Not set

National Hepatology and Tropical Medicine Research Institute, Cairo, Not set

Ain Shams University Hospital, Cairo, Not set

Cairo university, Giza, Not set

Clinique Ambroise Pare, Neuilly-sur-Seine, Not set

CHU de Nice Hopital de l Archet, Nice, Not set

Hopital Saint Joseph, Paris, Not set

Centre Hospitalier Lyon Sud, Pierre-Benite, Not set

CHRU Hopital de Pontchaillou, Rennes, Not set

CHRU Nancy Brabois, Vandoeuvre les Nancy, Not set

Charite - Campus Mitte, Berlin, Not set

JWG-University Hospital, Frankfurt, Not set

Universitatsklinikum Schleswig Holstein Kiel, Kiel, Not set

Universitaetsklinikum Mannheim, Mannheim, Not set

Universitaetsklinikum Ulm, Ulm, Not set

Alexandra General Hospital of Athens, Athens Attica, Not set

Evangelismos General Hospital of Athens, Athens, Not set

Hippokration Hospital, Athens, Not set

Sotiria General State Hospital of Chest Diseases, Athens, Not set

University Hospital of Heraklion, Heraklion, Not set

University Hospital Of Larissa, Larissa, Not set

Patras University Hospital, Patras, Not set

Hippokration Hospital, Thessaloniki, Not set

Magyar Honvedseg Egeszsegugyi Kozpont, Budapest, Not set

Semmelweis Egyetem, Budapest, Not set

Pecsi Tudomanyegyetem Orvostudomanyi Es Egeszsegtudomanyi Centrum, I. Belgyogyaszati Klinika, Pecs, Not set

Szegedi Tud Egyetem Szent Gyorgyi Albert Klin Kozp, Szeged, Not set

Haemek Medical Center, Afula, Not set

Rambam Medical Center, Haifa, Not set

Shaare Zedek Medical Center, Jerusalem, Not set

Rabin Medical Center Beilinson Campus, Petah Tikva, Not set

Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milano, Not set

Ospedale Classificato Equiparato Sacro Cuore Don Calabria di Negrar, Negrar ( Ve), Not set

Azienda Ospedaliera Universitaria Pisana, Pisa, Not set

Azienda Ospedaliera G.Salvini Ospedale di Rho, RHO, Not set

Policlinico Universitario Agostino Gemelli, Roma, Not set

Istituto Clinico Humanitas, Rozzano, Not set

Casa Sollievo della Sofferenza, San Giovanni Rotondo, Not set

KOKIKAI Tokatsu Tsujinaka Hospital, Abiko, Not set

Fukuoka University Chikushi Hospital, Chikushino-shi, Not set

Kitakyushu Municipal Medical Center, Fukuoka-ken, Not set

Fukuoka University Hospital, Fukuoka, Not set

Hiroshima University Hospital, Hiroshima shi, Not set

Hospital of the University of Occupational and Enviromental Health, Hukuoka, Not set

Sameshima Hospital, Kagoshima, Not set

Nara Medical University Hospital, Kashihara, Not set

Tsujinaka Hospital Kashiwanoha, Kashiwa, Not set

Nagasaki University Hospital, Nagasaki, Not set

Kojunkai Daido Clinic, Nagoya, Not set

Nagoya University Hospital, Nagoya, Not set

The Hospital of Hyogo College of Medicine, Nishinomiya, Not set

Okayama University Hospital, Okayama, Not set

Kinshukai Infusion Clinic, Osaka, Not set

JOHAS Osaka Rosai Hospital, Sakai, Not set

Sapporo Higashi Tokushukai Hospital, Sapporo, Not set

Tokyo Yamate Medical Center, Shinjuku-ku, Not set

Matsuda Hospital, Shizuoka, Not set

Osaka University Hospital, Suita, Not set

Kyorin University Hospital, Tokyo, Not set

Ieda Hospital, Toyota, Not set

Mie University Hospital, Tsu, Not set

Yokkaichi Hazu Medical Center, Yokkaichi, Not set

Yokohama Municipal Citizen's Hospital, Yokohama, Not set

The Speciality Hospital (TSH) / Advanced Clinical Center, Amman, Not set

Jordan University Hospital, Amman, Not set

Abdali Hospital, Amman, Not set

Irbid Specialty Hospital, Irbid, Not set

King Abdullah University Hospital, Irbid, Not set

Inje University Haeundae Paik Hospital, Busan, Not set

Yeungnam University Hospital, Daegu, Not set

Seoul National University Bundang Hospital, Gyeonggi-do, Not set

Seoul National University Hospital, Seoul, Not set

Gangnam Severance Hospital, Yonsei University Health System, Seoul, Not set

Academisch Medisch Centrum Universiteit van Amsterdam, Amsterdam, Not set

Radboudumc, Nijmegen, Not set

Erasmus MC, Rotterdam, Not set

UMC Utrecht, Utrecht, Not set

Gastromed Kralisz Romatowski Stachurska Sp. j., Bialystok, Not set

Centrum Medyczne Promed, Krakow, Not set

Centrum Medyczne Med Gastr, Lodz, Not set

Centrum Medyczne Medyk, Rzeszow, Not set

Twoja Przychodnia - Szczecinskie Centrum Medyczne, Szczecin, Not set

GASTROMED Kopon Zmudzinski i wspolnicy SP j Specjalistyczne Centrum Gastrologii i Endoskopii, Torun, Not set

WIP Warsaw IBD Point Profesor Kierkus, Warszawa, Not set

Melita Medical Sp. z o.o., Wroclaw, Not set

Centrum Medyczne Oporow, Wroclaw, Not set

Uls Braga - Hosp. Braga, Braga, Not set

Uls Sao Jose - Hosp. Sto Antonio Dos Capuchos, Lisboa, Not set

H. Santo António - Centro Hospitalar do Porto, Porto, Not set

King Fahad Specialist hospital, Dammam, Not set

King Abdulaziz Medical City, Jeddah, Not set

King Saud University Medical City, Riyadh, Not set

King Faisal Specialist Hospital & Research Center, Riyadh, Not set

Hosp Clinic de Barcelona, Barcelona, Not set

Hosp. Arquitecto Marcide, Ferrol, Not set

Hosp. Univ. Dr. Josep Trueta, Girona, Not set

Hosp. Univ. de La Princesa, Madrid, Not set

Hosp. Univ. Pta. de Hierro Majadahonda, Majadahonda, Not set

Hosp. Virgen Macarena, Sevilla, Not set

Hosp. Alvaro Cunqueiro, Vigo, Not set

Hosp. Univ. Miguel Servet, Zaragoza, Not set

Changhua Christian Hospital, Changhua, Not set

Taichung Veterans General Hospital, Taichung, Not set

National Taiwan University Hospital, Taipei City, Not set

Chang Gung Memorial Hospital Linkou Branch, Taoyuan City, Not set

Gazi University Medical Faculty, Ankara, Not set

Istanbul University Cerrahpasa Medical Faculty, Istanbul, Not set

Acibadem Kozyatagi Hospital, Istanbul, Not set

Ege University Medical Faculty, İzmir, Not set

Mersin University Medical Faculty Hospital, Mersin, Not set

Hull University Teaching Hospitals NHS Trust, Hull, Not set

London North West University Healthcare NHS Trust, London, Not set

Guys and St Thomas NHS Foundation Trust, London, Not set

St George's University Hospital NHS Foundation Trust, London, Not set

Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, Not set

Pennine Acute Hospitals NHS Trust, Salford, Not set

Conditions: Fistulizing Crohns Disease, Perianal Crohns Disease

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Study of Erdafitinib Intravesical Delivery System for Localized Bladder Cancer

NCT05316155

Recruiting

The purpose of the study in Part 1 (dose escalation) and in Part 2 (dose expansion) is to determine the recommended Phase 2 dose(s) (RP2D\[s\]) and evaluate preliminary clinical efficacy. Part 3 (dose expansion) will confirm safety and preliminary clinical activity at the RP2D. Part 4 (RP2D expansion) will assess the overall complete response (CR) in participants with intermediate-risk-non-muscle invasive bladder cancer (IR-NMIBC; means the cancer cells are only in the bladder's inner lining).

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/17/2025

Locations: University of Southern California, Los Angeles, California +46 locations

University of Southern California, Los Angeles, California

Urology Associates of Denver, Lone Tree, Colorado

Urological Research Network, Hialeah, Florida

Advanced Urology Institute, Largo, Florida

Advanced Urology Institute, Oxford, Florida

H Lee Moffitt Cancer Center, Tampa, Florida

Associated Urological Specialists, Chicago Ridge, Illinois

Northwestern University, Chicago, Illinois

Urology of Indiana, Greenwood, Indiana

Urologic Specialists of Northwest Indiana, Merrillville, Indiana

University of Kentucky, Lexington, Kentucky

Southern Urology LLC, Lafayette, Louisiana

Greater Boston Urology, Plymouth, Massachusetts

Associated Medical Professionals, Syracuse, New York

Levine Cancer Institute, Carolinas HealthCare System, Charlotte, North Carolina

Central Ohio Urology Group, Gahanna, Ohio

Carolina Urologic Research Center, Myrtle Beach, South Carolina

Low Country Urology Clinics, North Charleston, South Carolina

Urology Associates, Nashville, Tennessee

Urology San Antonio Research, San Antonio, Texas

Vancouver Prostate Centre Diamond Health Care Centre, Vancouver, British Columbia

Nova Scotia Health Authority, Halifax, Nova Scotia

Universitatsklinikum Frankfurt, Frankfurt am Main, Not set

Marien hospital Herne, Herne, Not set

Universitatsklinikum Munster, Münster, Not set

Universitaetsklinikum Ulm, Ulm, Not set

Rambam Medical Center, Haifa, Not set

Carmel Medical Center, Haifa, Not set

Rabin Medical Center, Petah Tikva, Not set

Tel Aviv Sourasky Medical Center, Tel Aviv Yafo, Not set

National Hospital Organization Kyushu Medical Center, Fukuoka, Not set

Yamanashi Prefectural Central Hospital, Kofu, Not set

Toyama University Hospital, Toyama-shi, Not set

National Cancer Center, Goyang-Si, Not set

Chonnam National University Hospital, Gwangju, Not set

Seoul National University Hospital, Seoul, Not set

Severance Hospital Yonsei University Health System, Seoul, Not set

The Catholic University of Korea Seoul St Marys Hospital, Seoul, Not set

Radboud Umcn, Nijmegen, Not set

UMC Utrecht, Utrecht, Not set

Fund. Puigvert, Barcelona, Not set

Hosp Univ Vall D Hebron, Barcelona, Not set

Hosp Clinic de Barcelona, Barcelona, Not set

Hosp Reina Sofia, Cordoba, Not set

Hosp. Univ. 12 de Octubre, Madrid, Not set

Hosp. Univ. La Paz, Madrid, Not set

Instituto Valenciano de Oncologia, Valencia, Not set

Conditions: Urinary Bladder Neoplasms, Receptors, Fibroblast Growth Factor

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Transmural Healing and Disease-Modifying Effect of Guselkumab in Crohn's Disease Patients

NCT06408935

Recruiting

The purpose of this study is to evaluate the efficacy of guselkumab in healing of all layers of the digestive tract (transmural healing) with the help of a score called Magnetic Resonance Index of Activity (MaRIA) based on a scan at Week 48.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/17/2025

Locations: The Queen Elizabeth Hospital, Adelaide, Not set +66 locations

The Queen Elizabeth Hospital, Adelaide, Not set

Concord Repatriation General Hospital, Concord, Not set

Northern Hospital, Melbourne, Not set

Fiona Stanley Hospital, Murdoch, Not set

Mater Hospital Brisbane, South Brisbane, Not set

Cliged, Macae, Not set

Instituto Mederi de Pesquisa e Saude, Passo Fundo, Not set

NPCRS Nucleo de Pesquisa Clinica do Rio Grande do Sul, Porto Alegre, Not set

INTEGRAL Pesquisa e Ensino, Votuporanga, Not set

Foothills Hospital, Calgary, Alberta

Western University & London Health Sciences Centre, London, Ontario

Hopital du Sacre-Coeur de Montreal, Montreal, Quebec

Nemocnice Ceske Budejovice a s, Ceske Budejovice, Not set

Hepato-gastroenterologie HK, s.r.o., Hradec Kralove, Not set

ISCARE a.s., Praha 9, Not set

Klinikum Augsburg, Augsburg, Not set

Charite Universitaetsmedizin Berlin, Berlin, Not set

Praxis Für Gastroenteroligie, Berlin, Not set

Medizinisches Versorgungszentrum (MVZ) Dachau, Dachau, Not set

Universitatsklinikum Frankfurt/ Medizinische Klinik 1, Frankfurt, Not set

Universitatsmedizin Gottingen, Gottingen, Not set

BSF Studiengesellschaft, Halle, Not set

Medizinische Hochschule Hannover, Hannover, Not set

Universitatsklinikum Schleswig Holstein, Kiel, Not set

Staedtisches Klinikum Lueneburg, Lüneburg, Not set

MVZ Portal 10, Münster, Not set

Siloah St Trudpert Klinikum, Pforzheim, Not set

Universitaetsklinikum Ulm, Ulm, Not set

Rambam Medical Center, Haifa, Not set

The Edith Wolfson Medical Center, Holon, Not set

Hadassah Medical Organization, Jerusalem, Not set

Galilee Medical Center, Nahariya, Not set

Rabin Medical Center, Petah Tikva, Not set

The Chaim Sheba Medical Center, Ramat Gan, Not set

Tel Aviv Sourasky Medical Center, Tel Aviv, Not set

Azienda Ospedaliera Policlinico S. Orsola-Malpighi, Bologna, Not set

IRCCS Ospedale San Raffaele, Milano, Not set

Asst Rhodense - Ospedale Di Rho, Rho, Not set

Universita Campus Bio-Medico di Roma, Roma, Not set

Fondazione Policlinico Tor Vergata, Roma, Not set

Fondazione Policlinico Universitario A Gemelli IRCCS, Roma, Not set

IRCCS Humanitas Rozzano-IBD Center Malattie Infiammatorie Croniche Intestinali, Rozzano, Not set

IRCCS Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo, Not set

NZOZ Centrum Medyczne KERmed, Bydgoszcz, Not set

Centrum Medyczne Medyk, Rzeszow, Not set

GASTROMED Sp. z o.o., Torun, Not set

WIP Warsaw IBD Point Profesor Kierkus, Warszawa, Not set

Melita Medical Sp. z o.o., Wroclaw, Not set

Centrum Medyczne Oporow, Wroclaw, Not set

EuroMediCare Szpital Specjalistyczny z Przychodnia, Wroclaw, Not set

ETG Zamosc, Zamosc, Not set

FNsP F.D.R. Banska Bystrica, Banska Bystrica, Not set

Cliniq s.r.o., Bratislava, Not set

KM Management spol. s r.o., Nitra, Not set

GASTRO I. s.r.o., Presov, Not set

Hosp. Gral. Univ. Dr. Balmis, Alicante, Not set

Hosp Reina Sofia, Cordoba, Not set

Complejo Hosp Univ. de Ferrol, Ferrol, Not set

Hosp. Univ. de La Paz, Ferrol, Not set

Hosp. Univ. de La Princesa, Madrid, Not set

Hosp. Univ. Pta. de Hierro Majadahonda, Madrid, Not set

Hosp. Clinico Univ. de Valencia, Valencia, Not set

Hosp. Alvaro Cunqueiro, Vigo, Not set

Chang-Hua Christian Hospital, Changhua, Not set

Far Eastern Memorial Hospital, New Taipei, Not set

National Taiwan University Hospital, Taipei, Not set

Taipei Veterans General Hospital, Taipei, Not set

Conditions: Crohn's Disease

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ATTUNE® Revision- Complex Primary in Total Knee Arthroplasty Population

NCT03153449

Recruiting

Five-year, Prospective, multi-center, non-randomized, non-controlled study of the ATTUNE® Revision total knee prostheses, utilizing the fixed bearing (FB) and rotating platform (RP) tibial component with the posterior stabilizing (PS) femoral component in complex primary total knee arthroplasty.

Gender:

ALL

Ages:

Between 22 years and 80 years

Trial Updated:

07/17/2025

Locations: Scripps Clinic Torrey Pines, San Diego, California +36 locations

Scripps Clinic Torrey Pines, San Diego, California

Colorado Joint Replacement, Denver, Colorado

Orthopaedic Center of the Rockies, Fort Collins, Colorado

Orthopedic Partners, Niantic, Connecticut

Florida Orthopedic Associates, DeLand, Florida

Arthroplasty Foundation, Louisville, Kentucky

University of Mississippi Medical Center, Jackson, Mississippi

Mery Hospital, Ozark, Missouri

Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire

Rothman Institute, Egg Harbor Township, New Jersey

UNC Orthopaedics, Chapel Hill, North Carolina

OrthoCarolina Hip and Knee Center, Charlotte, North Carolina

The Ohio State University Wexner Medical Center, Columbus, Ohio

Southern Joint Replacement Institute, Nashville, Tennessee

Texas Institute for Hip & Knee Surgery, Austin, Texas

Fondren Orthopedic Group, Houston, Texas

Finders Private Hospital, Adelaide, Not set

St. John of God Murdoch Hospital, Perth, Not set

Krankenhaus der Barmherzigen Schwestern Linz Betriebsgesellschaft m.b.H., Linz, Not set

MoRe Foundation, Antwerp, Not set

London Health Sciences Centre University Hospital, London, Ontario

Concordia Joint Replacement, Winnipeg, Not set

Centre Hospitalier Universitaire de Rennes, Rennes, Not set

Klinik und Poliklinik für Orthopädie und Sportorthopädie am Klinikum rechts der Isar der Technischen Universität Münche, Munich, Not set

Asklepios Orthopädische Klinik Lindenlohe, Schwandorf, Not set

South Infirmary Public Hospital, Cork, Not set

Ospedale Sacro Cuore, Verona, Not set

University Hospital Maastricht, Maastricht, Not set

Wellington Hospital, Wellington, Not set

Kantonsspital Baselland (Bruderholz, Liestal, Laufen), Department of Orthopaedic Surgery and Traumatology, Basel, Not set

Hampshire Hospitals NHS Foundation Trust, Basingstoke, Not set

Victoria Hospital NHS Fife, Kirkcaldy, Not set

Chapel Allerton Orthopaedic Centre, Leeds, Not set

James Cook University Hospital, Middlesbrough, Not set

The Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Foundation Trust, Oswestry, Not set

Nuffield Orthopaedic Centre, Oxford, Not set

Wrightington Hospital, Wigan, Not set

Conditions: Primary Knee Arthroplasty

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A Study of JNJ-87562761 in Participants With Relapsed or Refractory Multiple Myeloma

NCT06604715

Recruiting

The purpose of this study is to determine the recommended phase 2 dose(s) (RP2D\[s\]) of JNJ-87562761 in Part 1 (dose escalation), and to determine the safety and tolerability at RP2D in Part 2 (dose expansion) in participants with multiple myeloma (MM) whose disease has come back after treatment (relapsed) or hasn't responded to treatment (refractory).

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/17/2025

Locations: Princess Margaret Hospital, Toronto, Ontario +6 locations

Conditions: Relapsed or Refractory Multiple Myeloma

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