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All Clinical Trials in Canada
A listing of 3905 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
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A Phase 2 Trial of ENV-101 in Patients With Lung Fibrosis (WHISTLE-PF Trial)
Recruiting
The goal of this clinical trial is to evaluate the impact that ENV-101 has on lung function and key measures of fibrosis in adult patients with idiopathic pulmonary fibrosis (IPF). Another goal of this study is to better understand the safety and tolerability of ENV-101 in this patient population.
The goal of this clinical trial is to evaluate the impact that ENV-101 has on lung function and key measures of fibrosis in adult patients with idiopathic pulmonary fibrosis (IPF). Another goal of this study is to better understand the safety and tolerability of ENV-101 in this patient population. Read Less
Gender:
ALL
Ages:
40 years and above
Trial Updated:
08/21/2025
Locations: Research Site, Quilmes, Buenos Aires +80 locations
Research Site, Quilmes, Buenos Aires
Research Site, Buenos Aires, Not set
Research Site, Buenos Aires, Not set
Research Site, Mendoza, Not set
Research Site, Mendoza, Not set
Research Site, Camperdown, New South Wales
Research Site, Macquarie Park, New South Wales
Research Site, Brisbane, Queensland
Research Site, South Brisbane, Queensland
Research Site, Adelaide, South Australia
Research Site, Box Hill, Victoria
Research Site, Melbourne, Victoria
Research Site, Nedlands, Western Australia
Research Site, Graz, Steiermark
Research Site, Vienna, Not set
Research Site, Dinant, Namur
Research Site, Brussels, Not set
Research Site, Brussels, Not set
Research Site, Edmonton, Alberta
Research Site, Vancouver, British Columbia
Research Site, Ajax, Ontario
Research Site, Montréal, Quebec
Research Site, Sherbrooke, Quebec
Research Site, Trois-Rivières, Quebec
Research Site, Angers, Not set
Research Site, Bordeaux, Not set
Research Site, Caen, Not set
Research Site, Dijon, Not set
Research Site, Montpellier, Not set
Research Site, Nantes, Not set
Research Site, Paris, Not set
Research Site, Paris, Not set
Research Site, Rennes, Not set
Research Site, Tours, Not set
Research Site, Giessen, Hessen
Research Site, Immenhausen, Hessen
Research Site, Hannover, Lower Saxony
Research Site, Essen, North Rhine-Westphalia
Research Site, Berlin, Not set
Research Site, Leipzig, Not set
Research Site, Dublin, Leinster
Research Site, Dublin, Leinster
Research Site, Cork, Munster
Research Site, Dublin, Not set
Research Site, Bologna, Forli-Cesena
Research Site, Padova, Padua
Research Site, Florence, Tuscany
Research Site, Catania, Not set
Research Site, Milan, Not set
Research Site, Turin, Not set
Research Site, Seoul, (Deogyang District)
Research Site, Ulsan, (Dong District)
Research Site, Seoul, (Gangnam District)
Research Site, Busan, (Haeundae District)
Research Site, Seoul, (Seongbuk District)
Research Site, Seoul, (Songpa District)
Research Site, Seoul, (Yongsan District)
Research Site, Seoul, Not set
Research Site, Kuala Lumpur, Selangor
Research Site, Kuala Lumpur, Selangor
Research Site, Kuala Lumpur, Selangor
Research Site, Monterrey, Nuevo Leon
Research Site, Monterrey, Nuevo Leon
Research Site, San Nicolás De Los Garza, Nuevo Leon
Research Site, San Juan Del Río, Queretaro
Research Site, Chihuahua, Not set
Research Site, Mexico City, Not set
Research Site, Oaxaca, Not set
Research Site, Puebla, Not set
Research Site, Auckland, Not set
Research Site, Christchurch, Not set
Research Site, Hamilton, Not set
Research Site, Belfast, Not set
Research Site, Birmingham, Not set
Research Site, Birmingham, Not set
Research Site, Cambridge, Not set
Research Site, Edinburgh, Not set
Research Site, Exeter, Not set
Research Site, Leicester, Not set
Research Site, Londonderry, Not set
Research Site, London, Not set
Conditions: Idiopathic Pulmonary Fibrosis, Progressive Fibrosing Interstitial Lung Disease
A Study to Investigate Changes in Symptoms in Adult Participants With Chronic Rhinosinusitis With Nasal Polyposis Initiating Treatment With Tezepelumab
Recruiting
The main objective of this study is to evaluate treatment outcomes of tezepelumab among participants with physician-determined surgery-eligible CRSwNP, with or without asthma.
Study details include:
1. The study duration will be up to 40 weeks.
2. The treatment duration will be up to 24 weeks.
3. The visit frequency will be once every 4 weeks (Q4W).
The main objective of this study is to evaluate treatment outcomes of tezepelumab among participants with physician-determined surgery-eligible CRSwNP, with or without asthma.
Study details include:
1. The study duration will be up to 40 weeks.
2. The treatment duration will be up to 24 weeks.
3. The visit frequency will be once every 4 weeks (Q4W). Read Less
Gender:
ALL
Ages:
Between 18 years and 130 years
Trial Updated:
08/21/2025
Locations: Research Site, Newport Beach, California +43 locations
Research Site, Newport Beach, California
Research Site, Chicago, Illinois
Research Site, Chestnut Hill, Massachusetts
Research Site, Columbia, Missouri
Research Site, Plovdiv, Not set
Research Site, Sofia, Not set
Research Site, Sofia, Not set
Research Site, Hamilton, Ontario
Research Site, Quebec, Not set
Research Site, Quebec, Not set
Research Site, Le Kremlin-Bicêtre, Not set
Research Site, Lille, Not set
Research Site, Marseille, Not set
Research Site, Nantes Cedex 1, Not set
Research Site, Pierre Benite, Not set
Research Site, Poitiers, Not set
Research Site, Toulouse Cedex 9, Not set
Research Site, Düsseldorf, Not set
Research Site, Marburg, Not set
Research Site, Tubingen, Not set
Research Site, Villingen-Schwenningen, Not set
Research Site, Wiesbaden, Not set
Research Site, Budapest, Not set
Research Site, Budapest, Not set
Research Site, Nyiregyhaza, Not set
Research Site, Pécs, Not set
Research Site, Bologna, Not set
Research Site, Catania, Not set
Research Site, Firenze, Not set
Research Site, Napoli, Not set
Research Site, Padua, Not set
Research Site, Pisa, Not set
Research Site, Roma, Not set
Research Site, Rozzano, Not set
Research Site, Bialystok, Not set
Research Site, Bydgoszcz, Not set
Research Site, Zawadzkie, Not set
Research Site, Łódź, Not set
Research Site, Barcelona, Not set
Research Site, Barcelona, Not set
Research Site, Cadiz, Not set
Research Site, Madrid, Not set
Research Site, Salamanca, Not set
Research Site, Santiago de Compostela, Not set
Conditions: Chronic Rhinosinusitis With Nasal Polyps
Evaluation of Efficacy of Povetacicept in Adults With Immunoglobulin A Nephropathy (IgAN)
Recruiting
The purpose of this study is to evaluate the efficacy of povetacicept in adult participants compared with placebo in reducing proteinuria and preserving renal function.
The purpose of this study is to evaluate the efficacy of povetacicept in adult participants compared with placebo in reducing proteinuria and preserving renal function. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/21/2025
Locations: Apogee Clinical Research, LLC, Huntsville, Alabama +296 locations
Apogee Clinical Research, LLC, Huntsville, Alabama
Arizona Kidney Disease and Hypertension Center - Thomas Office, Phoenix, Arizona
Arizona Kidney Disease and Hypertension Center - Tuscon, Tucson, Arizona
West Coast Kidney, Fremont, California
The Medical Research Group, Inc. (FRENOVA), Fresno, California
CARE Institute - Carabello Kidney, Los Angeles, California
Providence Medical Foundation - Orange, Orange, California
UC Davis Health, Sacramento, California
Zuckerberg San Francisco General Hospital and Trauma Center, San Francisco, California
University of California San Francisco (UCSF), San Francisco, California
Western Nephrology, Arvada, Colorado
Colorado Kidney Care, Denver, Colorado
South Florida Nephrology Group PA, Research Div., Coral Springs, Florida
Dolphin Medical Research, Doral, Florida
Nephrology Associates of Central Florida, Hollywood, Florida
Tectum Medical Research, LLC, Hollywood, Florida
South Florida Research Institute, Lauderdale Lakes, Florida
Florida Kidney Physicians - Melbourne, Melbourne, Florida
Med-Care Research, Miami, Florida
Professional Research Center, Miami, Florida
Nephrology Associates of South Miami, Miami, Florida
On Health Research Center, Miami, Florida
Combined Research Orlando Phase I-IV, Orlando, Florida
BioResearch Partner, Pembroke Pines, Florida
D&H Pompano Research Center, Pompano Beach, Florida
Cordova Research Institute, LLC, Sweetwater, Florida
SciMerge Clinical Research, Atlanta, Georgia
Georgia Nephrology - Lawrenceville, Lawrenceville, Georgia
Randomize Now - Midtown, Newnan, Georgia
Care Institute - Chubbuck, ID, Chubbuck, Idaho
Care Institute - Idaho Falls, Idaho Falls, Idaho
CARE - Boise Kidney Institute, Meridian, Idaho
Bioluminux Clinical Research, Naperville, Illinois
Rockford Nephrology Associates, Rockford, Illinois
Nephrology Associates of Northern Illinois and Indiana (NANI), Indianapolis, Indiana
Nephrology Physicians LLC, Mishawaka, Indiana
Nephrology Associates of Kentuckiana, Louisville, Kentucky
Renal Associates of Baton Rouge, Baton Rouge, Louisiana
Velocity Clinical Research - Metairie, Metairie, Louisiana
Johns Hopkins School of Medicine, Baltimore, Maryland
St. Clair Nephrology Research, Shelby, Michigan
InterMed Consultants / DaVita Clinical Research, Edina, Edina, Minnesota
Mayo Clinic - Rochester, Rochester, Minnesota
Nephrology and Hypertension Associates, LTD, Tupelo, Mississippi
Somnos Clinical Research, Lincoln, Nebraska
DaVita Clinical Research Nevada - Las Vegas, Las Vegas, Nevada
Bioluminux Clinical Research New Jersey, Hamilton, New Jersey
New Jersey Kidney Care, LLC (FRENOVA), Jersey City, New Jersey
Renal Medicine Associates, Albuquerque, New Mexico
New York Nephrology Vasculitis and Glomerular Center, Albany, New York
Queens Hospital Center, Jamaica, New York
The Rogosin Institute, New York, New York
Metrolina Nephrology Associates, Charlotte, North Carolina
Thomas Jefferson University, Philadelphia, Pennsylvania
Nephrology Associates Inc, East Providence, Rhode Island
Hypertension & Nephrology Inc., Providence, Rhode Island
Knoxville Kidney Center (KKC), PLLC, Knoxville, Tennessee
Velocity Clinical Research, Abilene, Texas
Introscience Research LLC, Bellaire, Texas
Dallas Renal Group, Dallas, Texas
Renal Disease Research Institute - Dallas, Dallas, Texas
Davita Clinical Research - El Paso, El Paso, Texas
Prolato Clinical Research Center, Houston, Texas
Houston Medical Research Institute, LLC (FRENOVA), Houston, Texas
R & H Clinical Research, Katy, Texas
North Texas Kidney Disease Associates, Lewisville, Texas
P&I Clinical Research, LLC, Lufkin, Texas
Renal Specialists of Houston, Pasadena, Texas
Utah Kidney Research Institute, Salt Lake City, Utah
University of Vermont, Burlington, Vermont
Virginia Nephrology Group, Fairfax, Virginia
Kidney and Hypertension Specialist PLLC, Manassas, Virginia
Grampians Health Ballarat, Ballarat, Not set
Bendigo Hospital, Bendigo, Not set
Sunshine Coast University Hospital, Birtinya, Not set
Core Research Group Pty Ltd, Brisbane, Not set
Royal Prince Alfred Hospital, Camperdown, Not set
Monash Health, Clayton, Not set
Concord Repatriation General Hospital, Concord, Not set
Canberra Hospital, Garran, Not set
Renal Research Gosford, Gosford, Not set
Austin Hospital, Heidelberg, Not set
Western Health (Sunshine Hospital), Melbourne, Not set
Fiona Stanley Hospital, Murdoch, Not set
John Hunter Hospital, Newcastle, Not set
Sir Charles Gairdner Hospital, Perth, Not set
Melbourne Renal Research, Reservoir, Not set
Gold Coast University Clinical Trials Unit, Southport, Not set
Princess Alexandra Hospital, Woolloongabba, Not set
LKH Feldkirch, Feldkirch, Not set
Ordensklinikum Linz GmbH Elisabethinen, Linz, Not set
Medizinische Universitaet Wien, Vienna, Not set
Klinikum Wels- Grieskirchen, Wels-Grieskirchen, Not set
Universitaire Ziekenhuizen Leuven, Leuven, Not set
Centro de Pesquisa Clinica do Coracao, Aracaju, Not set
Freire Pesquisa Clinica, Belo Horizonte, Not set
Hospital Evangelico de Belo Horizonte, Belo Horizonte, Not set
Associacao Ampara a Saude, Brasilia, Not set
HU Hospital Walter Cantidio, Fortaleza, Not set
UFG Hospital de Clinicas da Universidad Federal de Golas, Goiania, Not set
Hospital de Caridade de Ijui, Ijui, Not set
Fundacao Pro-Rim Santa Catarina, Joinville, Not set
Centro Mineiro de Pesquisa, Juiz de Fora, Not set
Hospital das Clinicas da Universidade Federal de Pernambuco (UFPE), Recife, Not set
Hospital Universitario Pedro Ernesto - UERJ, Rio de Janeiro, Not set
Universidade Federal da Bahia, Salvador, Not set
Hospital Nove de Julho - DASA, Sao Paolo, Not set
Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Not set
Hospital do Rim Fundacao Oswaldo Ramos, Sao Paulo, Not set
St. Josephs Healthcare - Hamilton, Hamilton, Not set
Beijing Tsinghua Changgung Hospital, Beijing, Not set
Peking University First Hos, Beijing, Not set
Cangzhou People's Hospital, Cangzhou, Not set
The Second Norman Bethune Hospital of Jilin University, Changchun, Not set
Heping Hospital Affiliated to Changzhi Medical College, Changzhi, Not set
Sichuan People s Hospital, Chengdu, Not set
Bishan Hospital of Chongqing, Chongqing, Not set
The Second Affiliated Hospital of Chongqing Medical University, Chongqing, Not set
Dongguan People s Hospital, Dongguan, Not set
The First People's Hospital of Foshan, Foshan, Not set
Fuyang People's Hospital, Fuyang City, Not set
Fujian Medical University Union Hospital, Fuzhou, Not set
Guangdong Provincial People's Hospital, Guangzhou, Not set
The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Not set
Third Affiliated Hospital of Southern Medical University, Guangzhou, Not set
Zhujiang Hospital, Southern Medical University, Guangzhou, Not set
Affiliated Hospital of Guilin Medical University, Guilin, Not set
Guizhou Provincial People's Hospital, Guiyang, Not set
Sir Run Run Shaw Hospital Zhejiang University School of Medicine, Hangzhou, Not set
The First Affiliated Hospital of Anhui Medical University, Hefei, Not set
The Second Affiliated Hospital of Anhui Medical University, Hefei, Not set
The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Not set
The First Affiliated Hospital of Shandong First Medical University (Shandong Provincial Qianfoshan Hospital), Jinan, Not set
The Second Hospital of Shandong University, Jinan, Not set
Linyi People's Hospital, Lin Yi City, Not set
The First Affiliate Hospital of Henan University of Science and Technology, Luoyang, Not set
The First Affiliated Hospital of Nanchang University, Nanchang, Not set
Affiliated Hospital of Nantong University, Nantong City, Not set
Ningbo No.2 Hospital, Ningbo, Not set
The First Affiliated Hospital of Ningbo University, Ningbo, Not set
The First Affiliated Hospital of Xian JiaoTong University, Shaanxi, Not set
Shanghai General Hospital, Shanghai, Not set
Shengjing Hospital of China Medical University, Shenyang, Not set
The University of Hong Kong - Shenzhen Hospital, Shenzhen, Not set
The Second Hospital of Hebei Medical University, Shijiazhuang, Not set
Taian City Central Hospital, Taian, Not set
Second Hospital of Shanxi Medical University, Taiyuan, Not set
The Second Hospital of Tianjin Medical University, Tianjin, Not set
Wuxi People s Hospital, Wuxi, Not set
Xuancheng People s Hospital, Xuancheng, Not set
Yancheng No. 1 People's Hospital, Yancheng City, Not set
Affiliated Hospital Yangzhou University, Yangzhou City, Not set
Yantai YuHuangDing Hospital, Yantai, Not set
Yichang central people Hos, Yichang, Not set
General Hospital of Ningxia Medical University, Yinchuan, Not set
Clinical Hospital Dubrava, Zagreb, Not set
Clinical Hospital Merkur, Zagreb, Not set
Polyclinic Somed, Zagreb, Not set
Fakultni Nemocnice Brno, Brno, Not set
Vseobecna fakultni nemocnice v Praze, Nove Mesto, Not set
Nemocnice AGEL Novy Jicin a.s., Nový Jičín, Not set
Aalborg University Hospital, Aalborg, Not set
Center for Cancer and Organ Diseases - Rigshospitalet - Hornum Mads, Copenhagen, Not set
Hillerod Hospital, Hillerod, Not set
Sygehus Lillebaelt - Kolding, Kolding, Not set
North Estonia Medical Centre Foundation, Tallin, Not set
Tartu University Hospital, Tartu, Not set
Groupe Hospitalier Pellegrin, CHU De Bordeaux, Bordeaux, Not set
Hopitaux Universitaires Henri Mondor, Creteil, Not set
Centre Hospitalier Emile Roux, Le Puy-en-Velay, Not set
AP-HM - Hopital de La Conception, Marseille, Not set
CHU de Nantes - Hotel-Dieu, Nantes, Not set
Hopital Necker - Enfants Malades, Paris, Not set
Université Paris-Descartes / Hôpital Européen Georges Pompidou, Paris, Not set
Centre Hospitalier Universitaire (CHU) de Saint-Etienne - Hopital Nord, St Priest en Jarez, Not set
Centre Hospitalier de Valencienes, Valenciennes, Not set
Medizinische Klinik II, Aachen, Not set
Charite Universitaetsnedizin Berlin, Berlin, Not set
Universitaetsklinikum Carl Gustav Carus Dresden, Dresden, Not set
Universitaetsklinikum Leipzig, Leipzig, Not set
Queen Mary Hospital, Hong Kong, Not set
Prince Wales Hospital, Shatin, Not set
Tung Wah Hospital, Sheung Wan, Not set
Pecsi Tudomanyegyetem Klinikai Kozpont, Pecs, Not set
Cork University Hospital, Cork, Not set
Beaumont Hospital, Dublin, Not set
University Hospital Galway, Galway, Not set
University Hospital Waterford, Waterford, Not set
Barzilai Medical Center, Ashkelon, Not set
Rabin Medical Center, Petah Tivka, Not set
Sheba Medical Center, Tel Hashomer, Not set
Shamir Medical Center, Zerifin, Not set
Ospedale Policlinico San Martino IRCCS, Genova, Not set
Istituti Clinici Scientifici Maugeri-IRCCS Pavia, Pavia, Not set
Fujita Health University Hos, Aichi, Not set
Hyogo Amagasaki Gen Med Ctr, Amagasaki, Not set
Fukuoka University Hospital, Fukuoka, Not set
Japanese Red Cross Fukuoka Hospital, Fukuoka, Not set
Nihon University Itabashi Hospital, Itabashi-ku, Not set
Kanazawa Medical Uni Hospital, Kahoku, Not set
Kanazawa University Hospital, Kanazawa, Not set
Nara Med University Hos, Kashihara, Not set
Kasugai Municipal Hospital, Kasugai, Not set
Okayama University Hospital, Kita-ku, Not set
Kokura Memorial Hospital, Kitakyushu-shi, Not set
Kobe University Hospital, Kobe, Not set
Dokkyo Medical University Saitama Medical Center, Koshigaya, Not set
Japanese Red Cross Kyoto Daini Hospital, Kyoto-shi, Not set
Kyoto University Hospital, Kyoto, Not set
University of Miyazaki Hos, Miyazaki, Not set
Osaka City General Hospital, Osaka, Not set
Osaka General Medical Center, Osaka, Not set
Sapporo City General Hospital, Sapporo-shi, Not set
Tohoku University Tohoku University Hospital, Sendai-shi, Not set
Juntendo Hospital Affiliated to Juntendo University School of Medicine, Tokyo, Not set
Juntendo University Nerima Hospital, Tokyo, Not set
The Jikei Uni Daisan Hospital, Tokyo, Not set
The Jikei University Hospital, Tokyo, Not set
Tokyo Med University Hospital, Tokyo, Not set
Tokyo Women's Medical University Hospital, Tokyo, Not set
YUUAI Medical Center, Tomigusuku, Not set
Toyama Prefectural Central Hospital, Toyama-shi, Not set
Juntendo Uni Urayasu Hospital, Urayasu-shi, Not set
Hallym University Sacred Heart Hospital, Anyang, Not set
Seoul National University Hospital, Cheonan, Not set
Soon Chun Hyang University Cheonan Hospital, Cheonan, Not set
Keimyung University Dongsan Medical Center, Daegu, Not set
Kyungpook National University Hospital, Daegu, Not set
Konyang University Hospital, Daejeon, Not set
Hallym University Chuncheon Sacred Heart Hospital, Gangwon-do, Not set
Wonju Severance Christian Hospital, Gangwon-do, Not set
NHIS Ilsan Hospital, Goyang-si, Not set
Seoul National University Bundang Hospital, Seongnam-si, Not set
Asan Medical Center, Seoul, Not set
Chung-Ang University Hospital, Seoul, Not set
Konkuk University Medical Center, Seoul, Not set
Korea University Guro Hospital, Seoul, Not set
Korea University Medical Center (KUMC)-Korea University Anam Hospital, Seoul, Not set
Kyung Hee University Hospital at Gangdong (KUIMS), Seoul, Not set
Samsung Medical Center, Seoul, Not set
Severance Hospital, Yonsei University Health System, Seoul, Not set
The Catholic University of Korea Eunpyeong St. Mary's Hospital, Seoul, Not set
The Catholic University of Korea, Seoul ST. Mary's Hospital, Seoul, Not set
Ajou University Hospital, Suwon, Not set
Yongin Severance Hospital, Yongin-Si, Not set
Paula Stradina Clinical University Hospital, Riga, Not set
Vidzemes Hospital, Valmiera, Not set
Hospital of Lithuanian University of Health Sciences (LSMU) Kauno klinikos, Kaunas, Not set
Vilnius University Hospital Santaros Klinikos, Vilnius, Not set
Arke SMO SA de CV, Veracruz, Not set
University Medical Center Groningen, Groningen, Not set
UMC St. Radboud, Nijmegen, Not set
Haukeland University Hospital, Bergen, Not set
Oslo University Hospital - Ulleval Hospital, Oslo, Not set
SCM Sp. Z o.o, Krakow, Not set
Klinika Nefrologii, Centralny Szpital Kliniczny Uniwersytetu Medycznego w Łodzi, Lodzkie, Not set
Panstwowy Instytut Medyczny MSWiA - Klinika Chorob Wewnetrznych, Nefrologii i Transplantologii, Warszawa, Not set
Velocity Zamosc, Zamosc, Not set
Hospital Universitatio Vall d'Hebron, Barcelona, Not set
Hospital Universitario Reina Sofia, Cordoba, Not set
Hospital Universitari Arnau de Vilanova - Lleida, Lleida, Not set
Clinica Universidad de Navarra - Madrid, Madrid, Not set
Hospital Fundacion Jimenez Diaz, Madrid, Not set
Hospital Universitario Puerta de Hierro, Madrid, Not set
Hospital Universitario Ramon y Cajal, Madrid, Not set
Clinica Universidad de Navarra - Pamplona, Pamplona, Not set
Hospital Clinico Universitario de Santiago, Santiago de Compostela, Not set
Hospital Universitario Virgen Macarena, Sevilla, Not set
Hospital Universitario Doctor Peset, Valencia, Not set
Nephrology Clinic, Danderyd University Hospital, Danderyd, Not set
Sahlgrenska University Hospital, Goteborg, Not set
Karolinska University Hospital Huddinge, Huddinge, Not set
Linkoping University Hospital, Linköping, Not set
Uppsala University Hospital, Uppsala, Not set
Shuang Ho Hospital, New Taipei City, Not set
Tungs' Taichung Metroharbour Hospital, Taichung, Not set
National Taiwan University Hospital (NTUH), Taipei, Not set
Taipei Medical University Hospital, Taipei, Not set
Taipei Veterans General Hospital (TP-VGH), Taipei, Not set
Hacettepe University Hospital, Ankara, Not set
Istanbul University Cerrahpasa Medical Faculty, Istanbul, Not set
Kocaeli University Medical School, Kocaeli, Not set
Belfast Health and Social Care Trust, Belfast, Not set
FutureMeds - Soho Road Health Centre, Birmingham, Not set
Southmead Hospital, Bristol, Not set
Cambridge University - Addenbrooke's Hospital, Cambridge, Not set
FutureMeds - CPS Research, Glasgow, Not set
Queen Elizabeth University Hospital - Glasgow, Glasgow, Not set
Gloucestershire Royal Hospital, Gloucester, Not set
Leicester General Hospital, Leicester, Not set
Barts Health NHS Trust, London, Not set
Imperial College Healthcare NHS Trust, London, Not set
King's College Hospital, London, Not set
St Pancras Clinical Research, London, Not set
FutureMeds Newcastle, Newcastle-Upon-Tyne, Not set
FutureMeds Tesside, Stockton on Tees, Not set
FutureMeds Liverpool, Wirral (Liverpool), Not set
Conditions: Immunoglobulin A Nephropathy
A Study to Evaluate Efficacy and Safety of Giredestrant Compared With Fulvestrant (Plus a CDK4/6 Inhibitor), in Participants With ER-Positive, HER2-Negative Advanced Breast Cancer Resistant to Adjuvant Endocrine Therapy (pionERA Breast Cancer)
Recruiting
This is a Phase III, randomized, open-label multicenter study that will evaluate the efficacy and safety of giredestrant compared with fulvestrant, both in combination with the investigator's choice of a CDK4/6 inhibitor (palbociclib, ribociclib or abemaciclib), in participants with estrogen receptor-positive (ER+), human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer who have developed resistance to adjuvant endocrine therapy.
This is a Phase III, randomized, open-label multicenter study that will evaluate the efficacy and safety of giredestrant compared with fulvestrant, both in combination with the investigator's choice of a CDK4/6 inhibitor (palbociclib, ribociclib or abemaciclib), in participants with estrogen receptor-positive (ER+), human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer who have developed resistance to adjuvant endocrine therapy. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/21/2025
Locations: Southern Cancer Center, Daphne, Alabama +345 locations
Southern Cancer Center, Daphne, Alabama
Sutter Auburn Faith Hospital, Auburn, California
La Hematology Oncology Medical Group, Glendale, California
Marin Cancer Care Inc, Greenbrae, California
Kaiser Permanente - Harbor City, Harbor City, California
USC Norris Comprehensive Cancer Center, Los Angeles, California
USC Norris Cancer Center, Newport Beach, California
Sutter Medical Group, Roseville Clinic, Roseville, California
Sutter Health Medical Center, Sacramento, California
The Lundquist Institute for BioMedical Innovation at Harbor-UCLA Medical Cente, Torrance, California
Rocky Mountain Cancer Centers, Littleton, Colorado
Georgetown University Medical Center, Washington, District of Columbia
MedStar Washington Hosp Center, Washington, District of Columbia
AdventHealth Altamonte, Altamonte Springs, Florida
Florida Cancer Specialists - Fort Myers (Gladiolus Dr), Fort Myers, Florida
Cancer Specialists of North Florida, Jacksonville, Florida
Comprehensive Hematology Oncology, Saint Petersburg, Florida
Florida Cancer Specialists - Tampa, Tampa, Florida
Florida Cancer Specialists - EAST - SCRI - PPDS, West Palm Beach, Florida
Grady Health System, Atlanta, Georgia
Winship Cancer Institute of Emory University, Atlanta, Georgia
Advocate Lutheran General Hospital, Park Ridge, Illinois
Springfield Clinic, Springfield, Illinois
Mission Cancer + Blood - IMMC, Des Moines, Iowa
Baptist Health Lexington, Lexington, Kentucky
Baptist Health Hamburg, Lexington, Kentucky
Baptist Health Louisville, Louisville, Kentucky
New England Cancer Specialists, Scarborough, Maine
Maryland Oncology Hematology, Annapolis, Maryland
Frederick Health Hospital, Frederick, Maryland
Dana Farber Cancer Institute, Boston, Massachusetts
Henry Ford Hospital, Detroit, Michigan
HCA Midwest Division, Kansas City, Missouri
Cancer Care Center of O'Fallon, O'Fallon, Missouri
Oncology Hematology West - Legacy, Omaha, Nebraska
Astera Cancer Care East Brunswick, East Brunswick, New Jersey
Capital Health Regional Medical Center, Pennington, New Jersey
Queens Hospital Cancer Center, Jamaica, New York
Duke Women Cancer Care, Raleigh, North Carolina
Oncology Hematology Care, Cincinnati, Ohio
Asante Rogue Regional Medical Center, Medford, Oregon
Alliance Cancer Specialists, Bensalem, Pennsylvania
Ann B. Barshinger Cancer Institute, Lancaster, Pennsylvania
Abramson Cancer Center; Univ of Pennsylvania; Clinical Research Unit, Philadelphia, Pennsylvania
WellSpan Oncology Research, York, Pennsylvania
Brown University Health, Providence, Rhode Island
Medical University of South Carolina, Charleston, South Carolina
Avera Cancer Institute - Aberdeen, Aberdeen, South Dakota
Avera Cancer Institute, Sioux Falls, South Dakota
West Cancer Center, Germantown, Tennessee
SCRI Oncology Partners, Nashville, Tennessee
Texas Oncology Cancer Center, Austin, Texas
JPS Oncology & Infusion Center, Fort Worth, Texas
Texas Oncology - DFW, Irving, Texas
Virginia Cancer Specialists, PC, Fairfax, Virginia
Virginia Commonwealth University - Massey Cancer Center, Richmond, Virginia
Northwest Medical Specialties, Tacoma, Washington
West Virginia University Hospitals Inc, Morgantown, West Virginia
Aurora BayCare Medical Center, Green Bay, Wisconsin
Aurora St Lukes Medical Center, Milwaukee, Wisconsin
Inst. de Oncologia Angel H. Roffo, Buenos aires, Not set
Fundación CENIT para la Investigación en Neurociencias, Ciudad Autonoma Buenos Aires, Not set
Centro Oncologico Korben, Ciudad Autonoma Buenos Aires, Not set
Sanatorio Allende, Cordoba, Not set
Centro Oncologico Riojano Integral (CORI), La Rioja, Not set
Hospital Alemán, Recoleta, Not set
Instituto de Oncología de Rosario, Rosario, Not set
Sanatorio Parque S.A., Rosario, Not set
Hospital Provincial del Centenario, Rosario, Not set
Centro Oncológico de Excelencia, San Juan, Not set
Northern Beaches Hospital, Frenchs Forest, New South Wales
Nepean Hospital, Kingswood, New South Wales
Mater Hospital, North Sydney, New South Wales
University of the Sunshine Coast, Sippy Downs, Queensland
Mater Misericordiae Limited, South Brisbane, Queensland
Cancer Research SA, Adelaide, South Australia
Barwon Health, Geelong, Victoria
Sunshine Hospital, St Albans, Victoria
South West Healthcare, Warrnambool, Victoria
Lkh-Univ. Klinikum Graz, Graz, Not set
Medical University Innsbruck, Innsbruck, Not set
Ordensklinikum Linz Barmherzige Schwestern, Linz, Not set
Oö. Gesundheits- und Spitals-AG/LKH Steyr, Steyr, Not set
Medizinische Universität Wien, Wien, Not set
Cliniques Universitaires St-Luc, Bruxelles, Not set
GHdC Site Les Viviers, Charleroi, Not set
UZ Gent, Gent, Not set
UZ Leuven Gasthuisberg, Leuven, Not set
CHU de Liège (Sart Tilman), Liège, Not set
AZ St Maarten Campus Leopoldstr, Mechelen, Not set
Clinique Ste-Elisabeth, Namur, Not set
ZAS Sint Augustinus Wilrijk, Wilrijk, Not set
Obras Sociais Irma Dulce - Osid, Salvador, Bahia
Crio - Centro Regional Integrado de Oncologia, Fortaleza, Ceará
Hospital Sírio-Libanês, Brasilia, Distrito Federal
CEDOES - Diagnóstico e Pesquisa, Vitoria, Espírito Santo
Hospital Araujo Jorge, Goiania, Goiás
Hospital Sao Domingos, Sao Luis, Maranhão
Hospital do Cancer de Pernambuco - HCP, Recife, Pernambuco
Vencer Oncoclínica - Centro de Pesquisa do Piauí, Teresina, Piauí
Oncosite - Centro de Pesquisa Clinica Em Oncologia Ltda, Ijui, Rio Grande Do Sul
Santa Casa de Misericordia de Porto Alegre, Porto Alegre, Rio Grande Do Sul
Hospital Moinhos de Vento, Porto Alegre, Rio Grande Do Sul
Hospital Sao Lucas - PUCRS, Porto Alegre, Rio Grande Do Sul
Hospital Nossa Senhora da Conceicao, Porto Alegre, Rio Grande Do Sul
Hospital de Cancer de Barretos, Barretos, São Paulo
Hospital Amaral Carvalho, Jau, São Paulo
Hospital Sírio-Libanês, Sao Paulo, São Paulo
Clinica de Pesquisa e Centro de Estudos em Oncologia Ginecologica e Mamaria Ltda, Sao Paulo, São Paulo
Hospital A. C. Camargo, Sao Paulo, São Paulo
Instituto D'Or de Pesquisa e Ensino, Rio de Janeiro, Not set
Cross Cancer Institute, Edmonton, Alberta
Royal Victoria Regional Health Centre, Barrie, Ontario
Credit Valley Hospital/Carlo Fidani Peel Regional Cancer Centre, Mississauga, Ontario
Lakeridge Health Oshawa, Oshawa, Ontario
Thunder Bay Regional Health Sciences Centre, Thunder Bay, Ontario
North York General Hospital, Toronto, Ontario
Princess Margaret Cancer Center, Toronto, Ontario
CIUSSS du Saguenay Lac-Saint-Jean, Chicoutimi Hospital, Chicoutimi, Quebec
CISSS Chaudière-Appalaches, Levis, Quebec
Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec
McGill University Health Centre - Glen Site, Montreal, Quebec
CHU de Québec - Hôpital du Saint-Sacrement, Quebec City, Quebec
Hopital regional de saint jerome, Saint-jerome, Quebec
Centre hospitalier regional de Trois-Rivieres, Trois-Rivieres, Quebec
Allan Blair Cancer Centre, Regina, Saskatchewan
Saskatoon Cancer Centre, Saskatoon, Saskatchewan
Hospital las Higueras, Concepción, Región Bio Bio
Oncovida, Providencia, Not set
Clínica Puerto Montt, Puerto Montt, Not set
Centro De Cancer Universidad Catolica, Santiago, Not set
Instituto Nacional del Cancer, Santiago, Not set
Icegclinic, Santiago, Not set
Beijing Cancer Hospital, Beijing, Not set
the First Hospital of Jilin University, Changchun City, Not set
Hunan Cancer Hospital, Changsha CITY, Not set
West China Hospital of Sichuan University, Chengdu City, Not set
Sichuan Provincial People's Hospital, Chengdu, Not set
The First Affiliated Hospital, Chongqing Medical University, Chongqing, Not set
Fujian Medical University Union Hospital, Fuzhou City, Not set
No. 900 Hospital (Fuzhou General Hospital), Fuzhou City, Not set
Cancer Center, Sun Yat-sen University of Medical Sciences, Guangzhou City, Not set
The Second Affiliated Hospital of Zhejiang University College, Hangzhou, Not set
Harbin Medical University Cancer Hospital, Harbin, Not set
Jinan Central Hospital, Jinan City, Not set
Shandong Cancer Hospital, Jinan, Not set
The First People's Hospital of Yunnan Province, Kunming City, Not set
The First Affiliated Hospital to Henan University of Science and Technology, Luoyang, Not set
Guangxi Cancer Hospital of Guangxi Medical University, Nanning, Not set
Fudan University Shanghai Cancer Center, Shanghai City, Not set
Zhongshan Hospital Fudan University, Shanghai, Not set
Shanxi Province Cancer Hospital, Taiyuan City, Not set
Taizhou Hospital of Zhejiang Province, Taizhou, Not set
Tianjin Cancer Hospital, Tianjin, Not set
The Tumor Hospital of Xinjiang Medical University, Urumqi, Not set
Union Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan City, Not set
Hubei Cancer Hospital, Wuhan, Not set
The Second Affiliated Hospital of Xi'an Jiao Tong University, Xi'an City, Not set
Xi'an International Medical Center Hospital, Xian, Not set
The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Not set
Zhejiang Cancer Hospital, Zhejiang, Not set
The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Not set
Fundación CTIC - Centro de Tratamiento e Investigación sobre Cáncer Luis Carlos Sarmiento Angulo, Bogota, D.C., Not set
IPS Salud SURA Chipichape Cali, Cali, Not set
Oncomedica S.A., Monteria, Not set
Sociedad de Oncología y hematología del Cesar Ltda, Valledupar, Not set
Clinica CIMCA, San José, Not set
ICIMED Instituto de Investigación en Ciencias Médicas, San José, Not set
Proclinical Pharma, San José, Not set
Kuopio Uni Hospital, Kuopio, Not set
Tampere University Hospital, Tampere, Not set
ICO Paul Papin, Angers, Not set
Institut Sainte Catherine, Avignon, Not set
Hopital Jean Minjoz, Besancon, Not set
Centre Francois Baclesse, Caen, Not set
Centre Jean Perrin, Clermont Ferrand, Not set
Centre Hospitalier Saint Louis, La Rochelle, Not set
Centre Oscar Lambret, Lille, Not set
Centre Leon Berard, Lyon, Not set
Centre Cancerologie Grand Montpellier, Montpellier, Not set
Institut Jean Godinot, Reims CEDEX, Not set
Centre Eugene Marquis, Rennes, Not set
IUCT Oncopole, Toulouse, Not set
Gustave Roussy, Villejuif, Not set
Sozialstiftung Bamberg, Klinikum am Bruderwald, Gynäkologie, Bamberg, Not set
DONAU ISAR Klinikum Deggendorf, Deggendorf, Not set
Gynonco Düsseldorf, MVZ Medical Center GmbH, Düsseldorf, Not set
Universitätsklinikum Erlangen, Erlangen, Not set
Kliniken Essen-Mitte, Essen, Not set
Praxis für Interdisziplinäre Onkologie und Hämatologie GbR, Freiburg, Not set
Nationales Centrum für Tumorerkrankungen (NCT), Heidelberg, Not set
Universitätsklinikum des Saarlandes, Homburg/Saar, Not set
St. Elisabeth Krankenhaus Köln GmbH, Koeln, Not set
Rotkreuzklinikum München, Muenchen, Not set
Brustzentrum Rhein-Ruhr Servicegesellschaft mbH, Mönchengladbach, Not set
Anticancer Hospital Ag. Savas, Athens, Not set
Aretaieio Hospital of Athens, Athina, Not set
University Hospital of Larissa, Larissa, Not set
University Hospital of Patras Medical Oncology, Patras, Not set
European Interbalkan Medical Center, Thessaloniki, Not set
Celan S.A., Ciudad de Guatemala, Not set
INTEGRA Cancer Institute, Ciudad de Guatemala, Not set
Onco Go, S.A., Ciudad de Guatemala, Not set
Medi-k, ciudad de Guatemala, Not set
Grupo Angeles, Guatemala City, Not set
Oncomedica, Guatemala, Not set
Centro Medico Integral de Cancerologia CEMIC, Salcajá, Not set
Pamela Youde Nethersole Eastern Hospital, Hong Kong, Not set
Queen Mary Hospital, Hong Kong, Not set
Orszagos Onkologiai Intezet, Budapest, Not set
Bács-Kiskun Vármegyei Oktatókórház, Kecskemét, Not set
B-A-Z Vármegyei Központi Kórház és Egyetemi Oktatókórház, Miskolc, Not set
Nograd Varmegyei Szent Lazar Korhaz, Salgótarján, Not set
Max Super Speciality Hospital, New Delhi, Delhi
HealthCare Global Enterprises Limited, Banglore, Karnataka
MVR Cancer Centre and Research Institute, Kozhikode, Kerala
Regional Cancer Centre, Trivandrum, Kerala
Sir H. N. Reliance Foundation Hospital and Research Centre, Mumbai, Maharashtra
Grant Medical Foundation, Ruby Hall Clinic, Pune, Maharashtra
Sahyadri Speciality Hospital, Pune, Maharashtra
Sunact Cancer Institute, Thane, Maharashtra
Hadassah Ein Karem Hospital, Jerusalem, Not set
Rabin Medical Center, Petah Tikva, Not set
Sheba MC, Ramat Gan, Not set
Sourasky Medical Center, Tel-Aviv, Not set
Azienda Ospedaliera di Rilievo Nazionale e di Alta Specialita San Giuseppe Moscati, Avellino, Campania
Azienda Ospedaliera Universitaria Federico II, Napoli, Campania
Istituto Nazionale Tumori Irccs Fondazione g. PASCALE, Napoli, Campania
Policlinico S.Orsola-Malpighi, Bologna, Emilia-Romagna
I.R.S.T Srl IRCCS, Meldola, Emilia-Romagna
A.O. Universitaria Di Parma, Parma, Emilia-Romagna
RCCS - Centro di Riferimento, Aviano (PN), Friuli-Venezia Giulia
A.O. Universitaria S. Maria Della Misericordia Di Udine, Udine, Friuli-Venezia Giulia
Policlinico Universitario Agostino Gemelli, Roma, Lazio
Università Campus Bio-Medico di Roma, Roma, Lazio
Asst Papa Giovanni XXIII, Bergamo, Lombardia
Asst Degli Spedali Civili Di Brescia, Brescia, Lombardia
Irccs Istituto Nazionale Dei Tumori (Int), Milano, Lombardia
Istituto Clinico Humanitas, Rozzano, Lombardia
Ospedale Di Macerata, Macerata, Marche
A.O.U. Maggiore della Carità, Novara, Piemonte
Presidio Ospedaliero di Summa-Perrino, Brindisi, Puglia
Humanitas Centro Catanese Di Oncologia, Misterbianco (CT), Sicilia
Azienda Ospedaliera Universitaria Careggi, Florence, Toscana
IOV - Istituto Oncologico Veneto - IRCCS, Padova, Veneto
University of Nairobi - Institute of Tropical and Infectious Diseases, Nairobi, Not set
Kyungpook National University Chilgok Hospital, Daegu, Not set
Seoul National University Bundang Hospital, Seongnam-si, Not set
Korea University Anam Hospital, Seoul, Not set
Seoul National University Hospital, Seoul, Not set
Severance Hospital, Yonsei University Health System, Seoul, Not set
Asan Medical Center, Seoul, Not set
Gangnam Severance Hospital, Seoul, Not set
Ewha Womans University Mokdong Hospital, Seoul, Not set
Samsung Medical Center, Seoul, Not set
Ulsan University Hosiptal, Ulsan, Not set
Panamerican Clinical Research S.A de C.V., Guadalajara, Jalisco
RENATI INNOVATION S.A.P.I. de C.V, Guadalajara, Jalisco
Productos y Servicios Oncologicos Acacias SA de CV, Ciudad de México, Mexico CITY (federal District)
Centro Oncológico Hematológico Roma, Mexico City, Mexico CITY (federal District)
Hospital Zambrano Hellion TecSalud, Monterrey, Nuevo LEON
Centro de Investigacion Clinica de Oaxaca, Oaxaca de Juárez, Oaxaca
PanAmerican Clinical Research, Querétaro, Queréaro, Queretaro
CENEIT Oncologicos, Mexico City, Not set
Centro Medico Dalinde, Mexico City, Not set
Christchurch Hospital, Christchurch, Not set
Palmerston North Hospital, Palmerston North, Not set
Whangarei Hospital, Whangarei, Not set
Centro Medico Monte Carmelo, Arequipa, Not set
Hospital Goyeneche, Arequipa, Not set
Clínica Santa Beatriz, Lima, Not set
Hospital Nacional Arzobispo Loayza, Lima, Not set
Oncosalud Sac, Lima, Not set
Instituto Nacional de Enfermedades Neoplasicas, Lima, Not set
Clinica Internacional, Sede San Borja, Lima, Not set
Instituto Peruano de Oncología y Radioterapia, Lima, Not set
Clinica San Antonio;Investigaciones Trujillo S.A.C., Trujillo, Not set
Clinica Peruana Americana, Trujillo, Not set
Instituto Regional de Enfermedades Neoplasicas - IREN Norte, Trujillo, Not set
Instytut "Centrum Zdrowia Matki Polki", ?ód?, Not set
Centrum Onkologii im. Prof. Franciszka ?ukaszczyka, Bydgoszcz, Not set
Szpital Morski Im. Pck, Gdynia, Not set
Narodowy Instytut Onkologii Odzia? w Gliwicach, Gliwice, Not set
?wi?tokrzyskie Centrum Onkologii, Kielce, Not set
Przychodnia Lekarska KOMED, Roman Karaszewski, Konin, Not set
Szpital Wojewódzki im. Miko?aja Kopernika, Koszalin, Not set
Centrum Onkologii Ziemi Lubelskiej im. sw. Jana z Dukli, Lublin, Not set
Opolskie Centrum Onkologii, Opole, Not set
Mazowiecki Szpital Wojewódzki im. ?w. Jana Paw?a II, Siedlce, Not set
Zachodniopomorskie Centrum Onkologii, Szczecin, Not set
Narodowy Inst.Onkologii im.Sklodowskiej-Curie Panstw.Inst.Bad, Warszawa, Not set
IPO de Coimbra, Coimbra, Not set
Hospital de S. Francisco Xavier, Lisboa, Not set
Hospital da Luz, Lisboa, Not set
IPO do Porto, Porto, Not set
CHVNG/E_Unidade 1, Vila Nova de Gaia, Not set
PanOncology Trials, San Juan, Not set
Spitalul Clinic Filantropia, Bucuresti, Not set
Institutul Oncologic Prof. Dr. Alexandru Trestioreanu, Bucuresti, Not set
Amethyst Cluj, Cluj County, Not set
Institutul Oncologic Prof. Dr. Ion Chiricuta Cluj Napoca, Cluj Napoca, Not set
Centrul de Oncologie Sfantul Nectarie, Craiova, Not set
Institutul Regional de Oncologie Iasi, Iasi, Not set
Centrul de Oncologie Oncohelp, Timisoara, Not set
National University Hospital, Singapore, Not set
National Cancer Centre, Singapore, Not set
Icon Cancer Centre Gleneagles, Singapore, Not set
Institute of Oncology Ljubljana, Ljubljana, Not set
Cancercare Rondebosch Oncology, Cape Town, Not set
Cancercare, Port Elizabeth, Not set
Steve Biko Academic Hospital, Pretoria, Not set
Institut Catala d?Oncologia Hospital Germans Trias i Pujol, Badalona, Barcelona
Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Sant Andreu de La Barca, Barcelona
Hospital de Jerez de la Frontera, Jerez de La Frontera, Cadiz
Hospital Quiron de Madrid, Pozuelo de Alarcon, Madrid
Hospital Universitario Virgen de La Arrixaca, EL Palmar (EL Palmar), Murcia
Hospital Alvaro Cunqueiro, Vigo, Pontevedra
Hospital Universitari Dexeus - Grupo Quironsalud, Barcelona, Not set
Hospital Juan Ramon Jimenez, Huelva, Not set
Complejo Hospitalario de Jaen-Hospital Universitario Medico Quirurgico, Jaen, Not set
Centro Oncologico MD Anderson Internacional, Madrid, Not set
Hospital de Madrid Norte Sanchinarro- Centro Integral Oncologico Clara Campal, Madrid, Not set
Hospital Universitario Virgen Macarena, Sevilla, Not set
Hospital Universitario Virgen del Rocio, Sevilla, Not set
Instituto Valenciano Oncologia, Valencia, Not set
Hospital Arnau de Vilanova (Valencia) Servicio de Oncologia, Valencia, Not set
Hsin-Chu Branch of National Taiwan University Hospital, Hsinchu City, Not set
China Medical University Hospital, Taichung, Not set
Koo Foundation Sun Yat-Sen Cancer Center, Taipei City, Not set
Veterans General Hospital, Taipei, Not set
National Taiwan Uni Hospital, Taipei, Not set
Veterans General Hospital - Taichung, Xitun Dist., Not set
Chulalongkorn Hospital, Bangkok, Not set
National Cancer Institute, Bangkok, Not set
Rajavithi Hospital, Bangkok, Not set
Chulabhorn Hospital, Lak Si, Not set
Maharaj Nakorn Chiang Mai Hospital;Depart of Radiology, Muang Chiang MAI Delivery Branch 3, Not set
Songklanagarind Hospital, Songkhla, Not set
Sakarya Training and Research Hospital, Adapazar?, Not set
Ankara City Hospital, Ankara, Not set
Bakirkoy Dr. Sadi Konuk Egitim ve Arastirma Hastanesi, Tibbi Onkoloji, Bakirkoy / Istanbul, Not set
Katip Celebi University Ataturk Training and Research Hospital, Izmir, Not set
Goztepe Prof.Dr. Suleyman Yalcin City Hospital, Kadiköy, Not set
Mersin City Education and Research Hospital, Mersin, Not set
Medikal Park Samsun, Samsun, Not set
Hacettepe Uni Medical Faculty Hospital, Sihhiye/Ankara, Not set
Conditions: Estrogen Receptor-Positive, HER2-Negative Advanced Breast Cancer
EASi-KIDNEY™ (The Studies of Heart & Kidney Protection With BI 690517 in Combination With Empagliflozin)
Recruiting
This study is open to adults with chronic kidney disease at risk of progression. People with and without type 2 diabetes can take part in this study. The study is open to people who take other medicines called angiotensin converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARB). People who already take empagliflozin or any other sodium-glucose cotransporter-2 inhibitor (SGLT2i) can also join. The study is also open to people who currently do not take any of these treatments. Th... Read More
This study is open to adults with chronic kidney disease at risk of progression. People with and without type 2 diabetes can take part in this study. The study is open to people who take other medicines called angiotensin converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARB). People who already take empagliflozin or any other sodium-glucose cotransporter-2 inhibitor (SGLT2i) can also join. The study is also open to people who currently do not take any of these treatments. The purpose of this study is to find out whether a medicine called BI 690517 helps people with chronic kidney disease when taken in combination with a study medicine called empagliflozin. Worsening of kidney function increases the risk for kidney failure, cardiovascular disease, and heart disease.
This study has 2 parts. In the first part, participants get empagliflozin or placebo matching BI 690517 for at least 6 weeks. Participants continue taking ACEi or ARB throughout the study if such treatments are indicated. In the second part, participants are divided into 2 groups by chance. One group takes BI 690517 tablets and the other group takes placebo tablets. Placebo tablets look like BI 690517 tablets but do not contain any medicine. Participants take 1 tablet once a day in addition to empagliflozin for the duration of the study.
The doctors document when participants experience worsening of their kidney disease, go to hospital due to heart failure, or die of cardiovascular problems during the study. The time to these events is compared between the 2 treatment groups to see whether the treatment works. The study continues until the required number of events have occurred which is about 3 to 4 years. During this time, participants visit the study site about 4 times within the first 6 months. Then they visit the study site every 6 months. At the visits, doctors regularly check participants' health, take blood and urine samples, measure blood pressure and weight, check kidney function, and take note of any unwanted effects. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/21/2025
Locations: Apogee Clinical Research, Huntsville, Alabama +188 locations
Apogee Clinical Research, Huntsville, Alabama
Southwest Kidney Institute, Surprise, Arizona
Florida Kidney Physicians LLC, Jacksonville Beach, Florida
Total Research Group, LLC, Miami, Florida
East Coast Institute For Research LLC, Macon, Georgia
Kootenai Research Services, Coeur d'Alene, Idaho
Kansas Nephrology Research Institute, LLC, Wichita, Kansas
Lake Michigan Nephrology, Saint Joseph, Michigan
St. Clair Nephrology Research, LLC, Shelby, Michigan
Great Plains Nephrology, North Platte, Nebraska
Seacoast Kidney and Hypertension Specialists, Portsmouth, New Hampshire
Metrolina Nephrology Associates, PA, Charlotte, North Carolina
Brookview Hills Research Associates LLC, Winston-Salem, North Carolina
Northeast Endocrine Metabolic Associates, Philadelphia, Pennsylvania
Clinical Renal Associates, Upland, Pennsylvania
Nephrology Associates, Inc, East Providence, Rhode Island
Dallas Nephrology Associates Medical Clinic, DeSoto, Texas
Texas Institute for Kidney and Endocrine Disorders, Lufkin, Texas
Renal Specialists of Houston, PA, Pasadena, Texas
University of Virginia Health System, Charlottesville, Virginia
Tidewater Physicians Multispecialty Group, Newport News, Virginia
Providence Medical Research Center, Spokane, Washington
Fundação Oswaldo Ramos (Hospital do Rim), São Paulo, Not set
University of Alberta Hospital (University of Alberta), Edmonton, Alberta
Royal Inland Hospital, Kamloops, British Columbia
Kelowna General Hospital, Kelowna, British Columbia
Northern Health, Prince George, British Columbia
Fraser Health, Surrey, British Columbia
St. Paul's Hospital (Vancouver), Vancouver, British Columbia
CIUSSS Nord de l'île de Montreal, Quebec, Montréal
Queen's University, Kingston, Ontario
London Regional Cancer Program - London Health Sciences Ctr., London, Ontario
Lakeridge Health Oshawa, Oshawa, Ontario
Sunnybrook Health Sciences Centre, Toronto, Ontario
St. Michael's Hospital, Toronto, Ontario
Toronto General Hospital, Toronto, Ontario
Centre hospitalier de l'Université de Montréal (CHUM), Montréal, Not set
CHU de Quebec-Universite Laval Research Centre, Quebec, Not set
Herlev and Gentofte Hospital, Herlev, Not set
Kolding Hospital, Kolding, Not set
Rigshospitalet, København, København, Not set
Odense University Hospital, Odense, Not set
Zealand University Hospita; Roskilde, Roskilde, Not set
Universitätsklinikum Aachen, AöR, Aachen, Not set
Nephrologische Gemeinschaftspraxis Bad Nenndorf, Bad Nenndorf, Not set
Herz- und Diabeteszentrum Nordrhein-Westfalen, Bad Oeynhausen, Bad Oeynhausen, Not set
Praxis für Nierenkrankheiten und Dialyse Helle Mitte, Berlin, Not set
Universitätsklinikum Bonn AöR, Bonn, Not set
Städtisches Klinikum Braunschweig gGmbH, Braunschweig, Not set
Klinikum Dortmund gGmbH, Dortmund, Not set
Universitätsklinikum Düsseldorf, Düsseldorf, Not set
Dialysezentrum Elsenfeld, Elsenfeld, Not set
Agaplesion Markus Krankenhaus, Frankfurt am Main, Not set
Universitätsklinikum Frankfurt, Frankfurt am Main, Not set
ClinPhenomics CVC GmbH, Frankfurt, Not set
Nierenzentrum Freiburg, Freiburg, Not set
Universitätsklinikum Gießen und Marburg GmbH, Gießen, Not set
Universitätsklinikum Hamburg, Eppendorf, Hamburg, Not set
Medizinische Hochschule Hannover, Hannover, Not set
Zentrum Für Nieren Hochdruck und Stoffwechselerkrankungen, Hannover, Not set
BAG für Nephrologie und Dialyse, Heilbronn, Not set
Ruhr-Universität Bochum, Herne, Not set
Universität des Saarlandes, Homburg, Not set
Universitätsklinikum Schleswig-Holstein, Campus Kiel, Kiel, Not set
Klinikum Konstanz, Konstanz, Not set
Dr. Vehling-Kaiser MVZ GmbH, Landshut, Not set
KfH Nierenzentrum Leipzig, Leipzig, Not set
Universitätsklinikum Magdeburg AöR, Magdeburg, Not set
Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz, Not set
Klinikum der Universität München - Campus Innenstadt, München, Not set
Dialysezentrum Neckarsulm, Neckarsulm, Not set
Dialysezentrum Rotenburg, Rotenburg, Not set
MVZ Dialysezentrum Schweinfurt, Schweinfurt, Not set
Robert-Bosch-Krankenhaus GmbH, Stuttgart, Not set
KfH-Nierenzentrum Traunstein, Traunstein, Not set
Nephrologisches Zentrum Villingen-Schwenningen, Villingen-Schwenningen, Not set
Nierenzentrum Wiesbaden, Wiesbaden, Not set
Helios Universitätsklinikum Wuppertal, Wuppertal, Not set
Universitätsklinikum Würzburg AÖR, Würzburg, Not set
Manipal Hospital, Bangalore, Not set
St John's Medical College, Bangalore, Not set
Institute of Post Graduate Medical Education and Research, Chandigarh, Not set
Karnataka Medical college and research institute, Hubballi, Not set
Osmania Medical College & Hospital, Hyderabad, Not set
Nil Ratan Sircar Medical College & Hospital, Kolkata, Not set
IQRAA International hospital & research centre., Kozhikode, Not set
Dr Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Not set
Muljibhai Patel Urological Hospital, Nadiad, Not set
Max Super Specialty Hospital, Saket, New Delhi, Not set
Epitome Kidney Urology Institute and Lions Hospital, New Delhi, Not set
All India Institute of Medical Sciences, New Delhi, Not set
Indira Gandhi Institute of Medical Sciences, Patna, Not set
Jawaharlal Institute of Postgraduate Medical Education, Pondicherry, Not set
All India Institute of Medical Sciences, Raipur, Not set
Yashoda Hospitals - Secunderabad, Secunderabad, Not set
Kimshealth, Trivandrum, Not set
Christian Medical College, Vellore, Not set
Ospedale Civile Ss. Antonio e Biagio, Alessandria, Not set
Asti-Ospedale Cardinal Massaia, Asti, Not set
Azienda Universitaria Ospedaliera Consorziale Policlinico Bari, Bari, Not set
ASST Papa Giovanni XXIII, Bergamo, Not set
Policlinico S. Orsola-Malpighi, Bologna, Not set
Azienda Ospedaliera ARNAS G. Brotzu, Cagliari, Not set
Chieri-Ospedale Maggiore, Chieri, Not set
A.S.O.S. Croce e Carle, Cuneo, Not set
Firenze-Ospedale San Giovanni di Dio, Firenze, Not set
Azienda Ospedaliera Careggi, Firenze, Not set
Azienda Ospedaliera San Martino, Genova, Not set
Asst Santi Paolo E Carlo, Milano, Not set
Fondazione IRCCS San Gerardo dei Tintori, Monza, Not set
Ospedale Maggiore della Carità, Novara, Not set
Azienda Ospedaliera Unversitaria di Parma, Parma, Not set
Fondazione Salvatore Maugeri, Pavia, Not set
Azienda Ospedaliera Universitaria Pisana, Pisa, Not set
Prato-Ospedale Santo Stefano, Prato, Not set
Azienda Ospedaliera Sant'Andrea-Università di Roma La Sapienza, Roma, Not set
IRCCS Ospedale "Casa Sollievo della Sofferenza", San Giovanni Rotondo (Foggia), Not set
Azienda Sociosanitaria Ligure 2, Savona, Not set
Todi-Nuovo Ospedale Media Valle del Tevere, Todi, Not set
Torino-Ospedale Oftalmico, Turin, Not set
Ospedale Castelli - Verbania, Verbania, Not set
Ospedale San Bortolo, Vicenza, Not set
Hospital Ampang, Ampang Jaya, Not set
Hospital Selayang, Batu Caves, Not set
Hospital Sultanah Nora Ismail, Batu Pahat, Not set
Hospital Pulau Pinang-Pulau Pinang-21953, Georgetown, Not set
Hospital Raja Permaisuri Bainun, Ipoh, Not set
Hospital Sultanah Aminah, Johor Bahru, Not set
Hospital Kajang, Kajang, Selangor, Not set
Hospital Tengku Ampuan Rahimah, Klang, Not set
Hospital Queen Elizabeth, Kota Kinabalu, Not set
Hospital Kuala Lumpur, Kuala Lumpur, Not set
University of Malaya Medical Centre, Kuala Lumpur, Not set
Hospital Tuanku Ampuan Najihah, Kuala Pilah, Not set
Hospital Tengku Ampuan Afzan, Kuantan, Not set
Hospital Umum Sarawak, Kuching, Not set
Hospital Kulim, Kulim, Not set
Hospital Melaka, Melaka, Not set
Hospital Pakar Sultanah Fatimah, Muar, Not set
Hospital Seberang Jaya, Perai, Not set
Hospital Sultan Abdul Aziz Shah, Serdang, Not set
Hospital Tuanku Ja'afar, Seremban, Not set
Hospital Taiping, Taiping, Not set
Hospital Teluk Intan, Teluk Intan, Not set
Hospital Sultan Haji Ahmad Shah, Temerloh, Not set
ULS da Região de Aveiro, Aveiro, Not set
Unidade Local de Saúde do Algarve, E.P.E, Faro, Not set
SESARAM, Funchal, Not set
ULS de São João, Porto, Not set
Unidade Local de Saúde de Matosinhos, Senhora da Hora, Not set
Unidade Local De Saude Da Arrabida E.P.E., Setúbal, Not set
E-Da Hospital, Kaohsiung City, Not set
Lotung Poh-Ai Hospital, Luodong Township, Not set
Taipei Medical University-Shuang Ho Hospital, New Taipei City, Not set
Fu Jen Catholic University Hospital, New Taipei City, Not set
Tungs' Taichung MetroHarbor Hospital, Taichung, Not set
National Cheng Kung University Hospital, Tainan City, Not set
Cathay General Hospital, Taipei, Not set
Taipei Medical University Hospital, Taipei, Not set
Taipei Municipal Wanfang Hospital, Taipei, Not set
South Eastern Health & Social Care Trust, Belfast, Not set
Belfast Health and Social Care Trust, Belfast, Not set
Oakenhurst Medical Practice, Blackburn, Not set
University Hospitals Sussex NHS Foundation Trusts, Brighton, Not set
Southmead Hospital, Bristol, Not set
West Suffolk NHS Foundation Trust, Bury St Edmunds, Not set
Broomfield Hospital, Chelmsford, Not set
Hathaway Medical Centre, Chippenham, Not set
Clevedon Medical Centre, Clevedon, Not set
Queen Alexandra Hospital, Cosham, Not set
Daisy Hill Hospital, County Down, Not set
Dorset County Hospital NHS Foundation Trust, Dorset, Not set
Highland Clinical Research Facility, Fulwood, Not set
Gloucestershire Royal Hospital, Gloucester, Not set
Hereford County Hospital, Hereford, Not set
Aintree University Hospital, Liverpool, Not set
Altnagelvin Area Hospital, Londonderry, Not set
St George's University Hospitals NHS Foundation Trust, London, Not set
Imperial College Healthcare NHS Trust, London, Not set
Norfolk and Norwich University Hospital, Norfolk, Not set
Nottingham University Hospitals NHS Trust, Nottingham, Not set
Churchill Hospital, Oxford, Not set
Pickering Medical Practice, Pickering, Not set
Royal Berkshire Hospital, Reading, Not set
Alexandra Hospital, Redditch, Not set
Alexandra Hospital, Redditch, Not set
The Royal Shrewsbury Hospital, Shrewsbury, Not set
Great Western Hospital, Swindon, Not set
Royal Cornwall Hospital, Truro, Not set
Conditions: Kidney Disease, Chronic
A Study to Compare the Efficacy and Safety of BMS-986489 (BMS-986012+ Nivolumab Fixed Dose Combination) in Combination With Carboplatin Plus Etoposide to That of Atezolizumab With Carboplatin Plus Etoposide as First-Line Therapy in Participants With Extensive-Stage Small Cell Lung Cancer (TIGOS).
Recruiting
The Purpose of the Study is to Compare the Efficacy and Safety of BMS-986489 (Anti-fucosyl-GM1+ Nivolumab Fixed Dose Combination) in Combination with Carboplatin plus Etoposide to that of Atezolizumab with Carboplatin plus Etoposide as First-Line Therapy in Participants with Extensive-Stage Small Cell Lung Cancer.
The Purpose of the Study is to Compare the Efficacy and Safety of BMS-986489 (Anti-fucosyl-GM1+ Nivolumab Fixed Dose Combination) in Combination with Carboplatin plus Etoposide to that of Atezolizumab with Carboplatin plus Etoposide as First-Line Therapy in Participants with Extensive-Stage Small Cell Lung Cancer. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/21/2025
Locations: Southern Cancer Center, PC, Daphne, Alabama +190 locations
Southern Cancer Center, PC, Daphne, Alabama
Local Institution - 0283, Hot Springs, Arkansas
Florida Cancer Specialists - South, Fort Myers, Florida
Mid Florida Hematology and Oncology Center, Orange City, Florida
Florida Cancer Specialists - North, Saint Petersburg, Florida
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital, Marietta, Georgia
Illinois Cancer Care, Peoria, Illinois
Local Institution - 0037, Minneapolis, Minnesota
University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico
Duke Cancer Institute, Durham, North Carolina
Oncology Hematology Care, Cincinnati, Ohio
Local Institution - 0239, Cleveland, Ohio
Sanford Cancer Center, Sioux Falls, South Dakota
Local Institution - 0307, Knoxville, Tennessee
SCRI Oncology Partners, Nashville, Tennessee
Texas Oncology - Central/South Texas, Austin, Texas
Texas Oncology - Northeast Texas, Tyler, Texas
Oncology & Hematology Associates of Southwest Virginia, Inc., Roanoke, Virginia
Swedish Cancer Institute - Edmonds, Edmonds, Washington
Swedish Medical Center, Seattle, Washington
Local Institution - 0007, Tacoma, Washington
Instituto Alexander Fleming, Ciudad Autónoma de Buenos Aires, Buenos Aires
Hospital Italiano de Buenos Aires, ABB, Ciudad Autónoma De Buenos Aires
Local Institution - 0100, Buenos Aires, Ciudad Autónoma De Buenos Aires
Clinica Adventista Belgrano, Caba, Ciudad Autónoma De Buenos Aires
Instituto Médico Río Cuarto, Río Cuarto, Córdoba
GenesisCare - Campbelltown, Campbelltown, New South Wales
Nepean Hospital, Penrith, New South Wales
Gallipoli Medical Research Ltd, Brisbane, Queensland
Grampians Health, Ballarat Central, Victoria
St. John of God Murdoch Hospital, Murdoch, Western Australia
Klinikum Wels-Grieskirchen GmbH, Wels, Oberösterreich
Medizinische Universität Graz, Graz, Steiermark
Kepler Universitätsklinikum, Linz, Not set
Landeskrankenhaus Rankweil, Rankweil, Not set
Local Institution - 0250, Wien, Not set
Cliniques universitaires Saint-Luc, Brussels, Bruxelles-Capitale, Région De
UZ Gent, Gent, Oost-Vlaanderen
VITAZ, Sint-Niklaas, Oost-Vlaanderen
Local Institution - 0180, Leuven, Vlaams-Brabant
Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman, Liège, Not set
Local Institution - 0166, Fortaleza, Ceará
Local Institution - 0165, Porto Alegre, Rio Grande Do Sul
Local Institution - 0169, Porto Alegre, Rio Grande Do Sul
Local Institution - 0170, Santa Cruz do Sul, Rio Grande Do Sul
Local Institution - 0163, Itajaí, Santa Catarina
Local Institution - 0178, Barretos, São Paulo
Local Institution - 0111, Sao Paulo, São Paulo
Local Institution - 0289, Edmonton, Alberta
CIUSSS- saguenay-Lac-Saint-Jean, Chicoutimi, Quebec
Centre intégré de santé et de services sociaux du Bas Saint-Laurent- Hôpital régional de Rimouski, Rimouski, Quebec
IUCPQ, Quebec, Not set
Orlandi Oncologia, Santiago, Región Metropolitana De Santiago
Fundacion Arturo Lopez Perez (FALP), Santiago, Región Metropolitana De Santiago
Pontificia Universidad Catolica de Chile, Santiago, Región Metropolitana De Santiago
Bradfordhill, Santiago, Región Metropolitana De Santiago
Oncocentro Apys, Viña del Mar, Valparaíso
Beijing Cancer hospital, Beijing, Beijing
Beijing Chest Hospital,Capital Medical University, Beijing, Beijing
Chongqing University Cancer Hospital, Chongqing, Chongqing
Fujian Cancer Hospital, Fuzhou, Fujian
Local Institution - 0212, Xiamen, Fujian
Cancer Hospital of Shantou University Medical College, Shantou, Guangdong
Local Institution - 0227, Harbin, Heilongjiang
Local Institution - 0208, Wuhan, Hubei
Hubei Cancer Hospital, Wuhan, Hubei
Local Institution - 0216, Changsha, Hunan
The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi
Jilin Province Tumor Hospital, Changchun, Jilin
Local Institution - 0235, Shenyang, Liaoning
Xi'an International Medical Center Hospital, Xi'an, Shaanxi
Shandong Cancer Hospital, Jinan, Shandong
Local Institution - 0206, Shanghai, Shanghai
Zhongshan Hospital,Fudan University, Shanghai, Shanghai
Sichuan Cancer hospital, Chengdu, Sichuan
Tianjin Medical University Cancer Institute & Hospital, Tianjin, Tianjin
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang
Zhejiang Cancer Hospital, Hangzhou, Zhejiang
Taizhou Hospital of Zhejiang Province, Linhai, Zhejiang
Shanghai East Hospital, Shanghai, Not set
Masarykuv onkologicky ustav, Brno, Brno-město
Nemocnice AGEL Ostrava - Vitkovice a.s., Ostrava, Ostrava Město
Fakultni Thomayerova nemocnice, Prague, Praha 4
Fakultni nemocnice Olomouc, Olomouc, Not set
Hôpital Arnaud de Villeneuve - CHU Montpellier, Montpellier, Hérault
Chu Grenoble Alpes, La Tronche, Isère
CHU Lille - Institut Coeur Poumon, Lille Cedex, Nord
L Hopital Nord Ouest, Gleize, Rhône
Centre Hospitalier Lyon Sud, Pierre-Bénite, Rhône
Centre Hospitalier Intercommunal de Créteil, Créteil, Val-de-Marne
Gustave Roussy, Villejuif, Val-de-Marne
Assistance Publique Hôpitaux de Marseille - Hôpital Nord, Marseille, Not set
Institut Curie, Paris, Not set
Centre Hospitalier de Cornouaille Quimper - Concarneau, Quimper, Not set
Krankenhaus Nordwest GmbH, Frankfurt, Hessen
Pius Hospital Oldenburg, Oldenburg, Niedersachsen
Klinikum Köln-Merheim, Köln, Nordrhein-Westfalen
Krankenhaus Martha-Maria Halle-Dölau, Halle, Sachsen-Anhalt
Zentralklinik Bad Berka, Bad Berka, Thüringen
Local Institution - 0263, Berlin, Not set
Asklepios Klinik Gauting GmbH, Gauting, Not set
LungenClinic Grosshansdorf, Grosshansdorf, Not set
Thoraxklinik-Heidelberg gGmbH, Heidelberg, Not set
Robert Bosch Krankenhaus GmbH, Stuttgart, Not set
Errikos Dunant Hospital Center, Athens, Attikí
Thoracic General Hospital of Athens "I Sotiria", Athens, Attikí
"Theagenio" Cancer Hospital of Thessaloniki, Thessaloniki, Kentrikí Makedonía
European Interbalkan Medical Center, Thessaloniki, Thessaloníki
University General Hospital of Larissa, Larissa, Thessalía
Local Institution - 0278, New Delhi, Delhi
Local Institution - 0274, Bengaluru, Karnataka
Local Institution - 0271, Madurai, Tamil Nadu
Local Institution - 0277, Varanasi, Uttar Pradesh
Local Institution - 0273, Kolkata, West Bengal
Istituto Nazionale Tumori IRCCS Fondazione Pascale, Napoli, Campania
Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Lombardia
Istituto Nazionale Tumori Regina Elena, Rome, Roma
AO Santa Maria della Misericordia, Perugia, Umbria
Casa di Cura Dott. Pederzoli, Peschiera del Garda, Verona
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola, Bologna, Not set
Istituto Europeo di Oncologia IRCCS, Milano, Not set
National Hospital Organization Shikoku Cancer Center, Matsuyama, Ehime
Kurume University Hospital, Kurume, Fukuoka
Hokkaido University Hospital, Sapporo, Hokkaido
Kobe City Medical Center General Hospital, Kobe-shi, Hyogo
Kanazawa University Hospital, Kanazawa, Ishikawa
Kanagawa Cardiovascular and Respiratory Center, Yokohama, Kanagawa
Sendai Kousei Hospital, Sendai, Miyagi
Nara Medical University Hospital, Kashihara city, Nara
Kurashiki Central Hospital, Kurashiki, Okayama
Kansai Medical University Hospital, Hirakata, Osaka
Kindai University Hospital- Osakasayama Campus, Osaka Sayama, Osaka
Osaka Medical and Pharmaceutical University Hospital, Takatsuki, Osaka
Saitama Medical University International Medical Center, Hidaka, Saitama
Saitama Prefectural Cancer Center, Ina-machi, Saitama
Hamamatsu University Hospital, Hamamatsu, Shizuoka
Nippon Medical School Hospital, Bunkyo-ku, Tokyo
The Cancer Institute Hospital of JFCR, Koto, Tokyo
Fukushima Medical University, Fukushima, Not set
Chungbuk National University Hospital, Cheongju-si, Chungcheongbuk-do [Chungbuk]
Seoul National University Bundang Hospital, Seongnam, Kyǒnggi-do
Ajou University Hospital, Suwon-si, Kyǒnggi-do
Severance Hospital, Yonsei University Health System, Seoul, Seoul-teukbyeolsi [Seoul]
Asan Medical Center, Seoul, Seoul-teukbyeolsi [Seoul]
Keimyung University Dongsan Hospital, Daegu, Taegu-Kwangyǒkshi
Local Institution - 0311, Kuching, Sarawak
Local Institution - 0310, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur
Local Institution - 0312, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur
Local Institution - 0148, Pachuca, Hidalgo
Local Institution - 0146, Guadalajara, Jalisco
Local Institution - 0147, Monterrey, Nuevo León
Local Institution - 0145, Puebla, Not set
Amsterdam UMC, locatie VUmc, Amsterdam, Noord-Holland
Ziekenhuis Rijnstate, Arnhem, Not set
University Medical Center Groningen, Groningen, Not set
Szpital Specjalistyczny w Prabutach Spolka z o.o., Prabuty, Pomorskie
Przychodnia Lekarska KOMED, Konin, Wielkopolskie
Pratia Poznań, Poznań, Wielkopolskie
Centrum Onkologii im. Prof. Franciszka Lukaszczyka, Bydgoszcz, Not set
Instytut Centrum Zdrowia Matki Polki, Łódź, Łódzkie
SC Memorial Healthcare International SRL, Bucharest, București
Institutul Oncologic Bucuresti, Bucharest, București
SC Radiotherapy Center Cluj SRL, Florești, Cluj
Centrul de Oncologie "Sfântul Nectarie", Craiova, Dolj
Institutul Oncologic Cluj, Cluj, Not set
S.C. Centrul de Oncologie Euroclinic S.R.L., Iași, Not set
Institutul Regional de Oncologie, Iași, Not set
CHUS - Hospital Clinico Universitario, Santiago de Compostela, A Coruña [La Coruña]
Hospital Clínic de Barcelona, Barcelona, Catalunya [Cataluña]
Hospital de la Santa Creu i Sant Pau, Barcelona, Catalunya [Cataluña]
Hospital Universitario de Jaen, Jaen, Jaén
Hospital Universitario Ramón y Cajal, Madrid, Madrid, Comunidad De
Hospital Universitario 12 de Octubre, Madrid, Madrid, Comunidad De
Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid, Comunidad De
Hospital General Universitario de Valencia, Valencia, Valenciana, Comunitat
Local Institution - 0299, Sevilla, Not set
Hospital Universitario Virgen Del Rocio, Sevilla, Not set
Kantonsspital Graubünden, Chur, Not set
Kantonsspital Winterthur, Winterthur, Not set
UniversitätsSpital Zürich, Zürich, Not set
Local Institution - 0158, Cigli, İzmir
Local Institution - 0154, Adana, Not set
Local Institution - 0157, Ankara, Not set
Local Institution - 0177, Ankara, Not set
Local Institution - 0153, Istanbul, Not set
Local Institution - 0197, London, London, City Of
James Cook University Hospital, Central Middlesbrough, Middlesbrough
Aberdeen Royal Infirmary, Aberdeen, Not set
Local Institution - 0108, Leicester, Not set
The Christie NHS Foundation Trust, Manchester, Not set
The Clatterbridge Cancer Centre, Wirral, Not set
Conditions: Extensive-Stage Small Cell Lung Cancer
A Study to Investigate the Safety and Effectiveness of a Coagulation Factor IX Gene Insertion Therapy (REGV131-LNP1265) in Pediatric, Adolescent and Adult Participants With Hemophilia B
Recruiting
Participants in this study have a genetic mutation, specifically in the coagulation (blood clotting) Factor 9 gene that causes severe or moderately severe hemophilia B. This study is researching an experimental gene insertion therapy (the adding of a gene into your DNA) called REGV131-LNP1265, also called the "study drug". Gene insertion therapy aims to teach the body how to produce clotting factor long-term, without the need for factor replacement therapy.
The main aim of this study is to find... Read More
Participants in this study have a genetic mutation, specifically in the coagulation (blood clotting) Factor 9 gene that causes severe or moderately severe hemophilia B. This study is researching an experimental gene insertion therapy (the adding of a gene into your DNA) called REGV131-LNP1265, also called the "study drug". Gene insertion therapy aims to teach the body how to produce clotting factor long-term, without the need for factor replacement therapy.
The main aim of this study is to find a safe and well-tolerated dose of the study drug by checking the side effects that may happen from taking it.
The study is looking at several other research questions including:
* How much study drug is in the blood at different times
* Whether the body makes antibodies against parts of the study drug, which could make the drug less effective or could lead to side effects. Antibodies are proteins produced by the body's immune system in response to a foreign substance
* Whether the body makes antibodies against the clotting factor replacement therapy
* How quality of life is affected by hemophilia B and if it changes after taking study drug
* How joint health is affected by hemophilia B and if it changes after taking study drug
* How often visits are required for the emergency room, urgent care center, physician's office, hospital, telephone or online are required as a result of bleeding events, and if the frequency changes after taking study drug
* How often factor replacement therapy is needed, both on a regular basis for prevention of bleeding, and as needed to treat bleeding events (and it if changes after taking study drug)
* Whether there is a difference in 2 different methods for measuring Factor 9 activity in the blood Read Less
Gender:
MALE
Ages:
18 years and above
Trial Updated:
08/21/2025
Locations: Orthopaedic Hemophilia Treatment Center, Los Angeles, California +21 locations
Orthopaedic Hemophilia Treatment Center, Los Angeles, California
David Geffen School of Medicine at UCLA, Los Angeles, California
Children's Hospital Los Angeles, Los Angeles, California
University of California Davis, Sacramento, California
University California San Francisco, San Francisco, California
Yale HTC, New Haven, Connecticut
Tulane University School of Medicine, Louisiana Center for Bleeding and Clotting Disorders, New Orleans, Louisiana
University of Michigan, Ann Arbor, Michigan
Children's Hospital of Philadelphia (CHOP), Philadelphia, Pennsylvania
McMaster University Medical Centre - Hamilton Health Sciences, Hamilton, Ontario
Hopital Necker, Paris, Ile-de-France
Hospices Civils de Lyon, Bron, Lyon
University Hospital Frankfurt, Frankfurt, Hesse
Hospital Universitario Central de Asturias, Oviedo, Asturias
Complejo Hospitalario Universitario de A Coruna, A Coruna, Galicia
Hospital Clinico Universitario Virgen De La Arrixaca, El Palmar, Murcia
Hospital Universitario Miguel Servet, Zaragoza, Not set
Glasgow Royal Infirmary - Clinical Research Facility, Glasgow, Scotland
Addenbrooke's Hospital, Cambridge University Hospitals NHS FT, Cambridge, Not set
Royal Free London NHS Foundation Trust, London, Not set
St. Thomas' Hospital, London, Not set
Hammersmith Hospital Comprehensive Care Centre, London, Not set
Conditions: Hemophilia B
A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)
Recruiting
This study will assess if adding sacituzumab tirumotecan with pembrolizumab after surgery is effective in treating NSCLC for participants not achieving pathological complete response. The primary hypothesis of this study is sacituzumab tirumotecan plus pembrolizumab is superior to pembrolizumab monotherapy with respect to disease free survival (DFS) as assessed by blinded independent central review (BICR).
This study will assess if adding sacituzumab tirumotecan with pembrolizumab after surgery is effective in treating NSCLC for participants not achieving pathological complete response. The primary hypothesis of this study is sacituzumab tirumotecan plus pembrolizumab is superior to pembrolizumab monotherapy with respect to disease free survival (DFS) as assessed by blinded independent central review (BICR). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/21/2025
Locations: UAMS Winthrop P. Rockefeller Cancer Institute ( Site 0060), Little Rock, Arkansas +223 locations
UAMS Winthrop P. Rockefeller Cancer Institute ( Site 0060), Little Rock, Arkansas
Highlands Oncology Group-Research Department ( Site 0062), Springdale, Arkansas
Beverly Hills Cancer Center ( Site 0070), Beverly Hills, California
The Angeles Clinic and Research Institute ( Site 0040), Los Angeles, California
The Angeles Clinic and Research Institute- A Cedars-Sinai Affiliate ( Site 0079), Los Angeles, California
San Francisco Oncology Associates ( Site 0066), San Francisco, California
Stamford Hospital ( Site 0083), Stamford, Connecticut
Mount Sinai Cancer Center ( Site 0038), Miami Beach, Florida
Mid Florida Hematology and Oncology Center ( Site 0018), Orange City, Florida
Emory University School of Medicine-Phase I ( Site 0056), Atlanta, Georgia
Northside Hospital ( Site 0055), Atlanta, Georgia
Centricity Research Columbus Cancer Center ( Site 0005), Columbus, Georgia
Southeastern Regional Medical Center ( Site 0065), Newnan, Georgia
Lewis Cancer and Research Pavilion ( Site 0063), Savannah, Georgia
Archbold Cancer Center ( Site 0071), Thomasville, Georgia
Edward-Elmhurst Healthcare, Elmhurst Hospital-Nancy W. Knowles Cancer Center ( Site 0017), Elmhurst, Illinois
Edward-Elmhurst Healthcare, Edward Hospital-Edward Cancer Center ( Site 0078), Naperville, Illinois
Parkview Research Center at Parkview Regional Medical Center ( Site 0089), Fort Wayne, Indiana
Indiana University Health Arnett Cancer Center ( Site 0076), Lafayette, Indiana
Saint Elizabeth Medical Center Edgewood-Cancer Care Center ( Site 0061), Edgewood, Kentucky
Our Lady of the Lake Physician Group-Medical Oncology ( Site 0080), Baton Rouge, Louisiana
Allina Health Cancer Institute - Abbott Northwestern Hospital ( Site 0027), Minneapolis, Minnesota
Mercy Research - David C. Pratt Cancer Center ( Site 0006), Saint Louis, Missouri
Renown Regional Medical Center-Renown Health Medical Oncology ( Site 0037), Reno, Nevada
Atlantic Health Morristown Medical Center ( Site 0077), Morristown, New Jersey
Cayuga Medical Center ( Site 0086), Ithaca, New York
Stony Brook University-Cancer Center ( Site 0054), Stony Brook, New York
Sanford Fargo Medical Center-Roger Maris Cancer Center ( Site 0057), Fargo, North Dakota
Oregon Health and Science University ( Site 0052), Portland, Oregon
Lancaster General Hospital - Ann B Barshinger Cancer Institute ( Site 0068), Lancaster, Pennsylvania
Medical University of South Carolina-Hollings Cancer Center ( Site 0045), Charleston, South Carolina
Sanford Cancer Center ( Site 0053), Sioux Falls, South Dakota
Avera Cancer Institute- Research ( Site 0090), Sioux Falls, South Dakota
University of Tennessee Medical Center Knoxville ( Site 0082), Knoxville, Tennessee
Millennium Research & Clinical Development ( Site 0039), Houston, Texas
Huntsman Cancer Institute ( Site 0042), Salt Lake City, Utah
Hospital Italiano de Buenos Aires-Clinical Oncology ( Site 0213), Ciudad Autonoma de Buenos Aires, Buenos Aires
Hospital Británico de Buenos Aires-Oncology ( Site 0207), Ciudad autónoma de Buenos Aires, Buenos Aires
Sanatorio Británico-Clinical Oncology Department ( Site 0206), Rosario, Santa Fe
Sanatorio Parque ( Site 0205), Rosario, Santa Fe
Clínica Mayo de Urgencias Médicas Cruz Blanca S.R.L ( Site 0217), San Miguel de Tucuman, Tucuman
Hospital Aleman-Oncology ( Site 0202), Buenos Aires, Not set
Hospital Privado Universitario de Córdoba-Hematology and Oncology ( Site 0204), Cordoba, Not set
Westmead Hospital ( Site 0701), Westmead, New South Wales
The Prince Charles Hospital ( Site 0700), Brisbane, Queensland
Fiona Stanley Hospital-Medical Oncology ( Site 0705), Murdoch, Western Australia
Ordensklinikum Linz GmbH Elisabethinen-Department of Pneumology ( Site 1402), Linz, Oberosterreich
Medizinische Universitaet Innsbruck-Department for Internal Medicine V ( Site 1403), Innsbruck, Tirol
Klinik Floridsdorf-Abteilung für Innere Medizin und Pneumologie ( Site 1400), Wien, Not set
Antwerp University Hospital-Thoracic Oncology ( Site 1503), Edegem, Antwerpen
Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant-Godinne - Site Godi ( Site 1502), Yvoir, Namur
VITAZ ( Site 1500), Sint-Niklaas, Oost-Vlaanderen
Liga Norte Riograndense Contra o Câncer ( Site 0301), Natal., Rio Grande Do Norte
Irmandade da Santa Casa de Misericórdia de Porto Alegre ( Site 0303), Porto Alegre, Rio Grande Do Sul
Hospital Nossa Senhora da Conceição ( Site 0302), Porto Alegre, Rio Grande Do Sul
Instituto de Oncologia Saint Gallen ( Site 0319), Santa Cruz do Sul, Rio Grande Do Sul
Fundação Pio XII - Hospital de Câncer de Barretos ( Site 0304), Barretos, Sao Paulo
Fundação Faculdade Regional de Medicina de São José do Rio Preto ( Site 0313), São José do Rio Preto, Sao Paulo
Centre Intégré de Santé et de Services Sociaux de la Montérégie-Centre ( Site 0100), Greenfield Park, Quebec
St. Marys Hospital Center ( Site 0107), Montreal, Quebec
Centre Hospitalier de l'Université de Montréal ( Site 0104), Montréal, Quebec
FALP-UIDO ( Site 0401), Providencia, Region M. De Santiago
Centro de Estudios Clínicos SAGA-CECSAGA ( Site 0404), Santiago., Region M. De Santiago
Bradfordhill-Clinical Area ( Site 0400), Santiago, Region M. De Santiago
ONCOCENTRO APYS-ACEREY ( Site 0410), Viña del Mar, Valparaiso
Beijing Cancer hospital-Thoracic Surgery department I ( Site 1301), Beijing, Beijing
Beijing Peking Union Medical College Hospital-Thoracic surgery department ( Site 1302), Beijing, Beijing
Peking University People's Hospital. ( Site 1300), Beijing, Beijing
Fujian Cancer Hospital-oncology department ( Site 1314), Fuzhou, Fujian
The First Affiliated Hospital of Guangzhou Medical University-thoracic surgery department ( Site 1320), Guangzhou, Guangdong
Southern Medical University Nanfang Hospital-Thoracic surgery department ( Site 1313), Guangzhou, Guangdong
Henan Cancer Hospital-henan cancer hospital ( Site 1316), Zhengzhou, Henan
Union Hospital Tongji Medical College Huazhong University of Science and Technology-Thoracic Surgery ( Site 1306), Wuhan, Hubei
Hubei Cancer Hospital ( Site 1308), Wuhan, Hubei
Xiangya Hospital Central South University-Thoracic surgery ( Site 1311), Changsha, Hunan
Hunan Cancer Hospital ( Site 1312), Changsha, Hunan
Nanjing First Hospital ( Site 1310), Nanjing, Jiangsu
The First Affiliated Hospital of Soochow University-Thoracic Surgery Department ( Site 1318), Suzhou, Jiangsu
The First affiliated hospital of Nanchang University (Xianghu campus) ( Site 1330), Nanchang, Jiangxi
The First Hospital of Jilin University ( Site 1324), Changchun, Jilin
The Second Affiliated Hospital of Air Force Medical University ( Site 1332), Xian, Shaanxi
Shandong Cancer Hospital ( Site 1321), Jinan, Shandong
Zhongshan Hospital Fudan University ( Site 1325), Shangai, Shanghai
Shanghai Pulmonary Hospital-Thoracic Surgery department ( Site 1304), Shanghai, Shanghai
Sichuan Cancer hospital. ( Site 1327), Chengdu, Sichuan
The Second People's Hospital of Neijiang ( Site 1322), Neijiang, Sichuan
Yunnan Province Cancer Hospital ( Site 1315), Kunming, Yunnan
The first Affiliated Hospital, Zhejiang University School of-Thoracic Cardiovascular Surgery Ward ( Site 1303), Hangzhou, Zhejiang
Zhejiang Cancer Hospital ( Site 1309), Hangzhou, Zhejiang
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine ( Site 1328), Hangzhou, Zhejiang
Taizhou Hospital of Zhejiang Province ( Site 1329), Linhai, Zhejiang
Ningbo No. 2 Hospital ( Site 1305), Ningbo, Zhejiang
Masarykuv onkologicky ustav-Klinika komplexni onkologicke pece ( Site 1600), Brno, Brno-mesto
Nemocnice AGEL Ostrava - Vitkovice a.s.-Plicni oddeleni ( Site 1601), Ostrava, Ostrava Mesto
CHRU de Brest ( Site 1804), Brest, Finistere
CHU de Toulouse - Hopital Larrey-service de pneumologie ( Site 1801), Toulouse, Haute-Garonne
CHU Charles Nicolle ( Site 1803), Rouen, Haute-Normandie
Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren ( Site 1805), Limoges, Haute-Vienne
Groupe hospitalier Paris saint Joseph. ( Site 1807), Paris, Ile-de-France
Clinique Teissier Groupe ( Site 1811), Valenciennes, Nord
Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne-ONCOLOGY ( Site 1810), Clermont-Ferrand, Puy-de-Dome
Hospices Civils de Lyon - Hopital Louis Pradel ( Site 1809), Bron, Rhone
HIA Sainte Anne ( Site 1800), Toulon, Var
Hôpital Tenon ( Site 1802), Paris, Not set
Klinikum Esslingen-Klinik für Kardiologie und Pneumologie ( Site 1914), Esslingen, Baden-Wurttemberg
Katholisches Klinikum Koblenz ( Site 1911), Koblenz, Rheinland-Pfalz
Krankenhaus Martha-Maria Halle-Dölau-Klinik für Innere Medizin II ( Site 1908), Halle, Sachsen-Anhalt
Universitätsklinikum Leipzig ( Site 1915), Leipzig, Sachsen
SRH Wald-Klinikum Gera-Lungenkrebszentrum ( Site 1900), Gera, Thuringen
Vivantes Hospital Spandau-Klinik für Innere Medizin, Hämatologie, Onkologie und Gastroenterologie- ( Site 1912), Berlin, Not set
Helios Klinikum Emil von Behring Berlin-Zehlendorf ( Site 1916), Berlin, Not set
UNIVERSITY HOSPITAL OF PATRAS-DIVISION OF ONCOLOGY ( Site 2006), Patras, Achaia
251 Hellenic Air Force General Hospital ( Site 2003), Athens, Attiki
THORACIC GENERAL HOSPITAL OF ATHENS "I SOTIRIA"-3rd Dept of Internal Medicine and Laboratory, Oncol ( Site 2000), Athens, Attiki
Athens Medical Center ( Site 2005), Athens, Attiki
Metaxa Cancer Hospital of Piraeus ( Site 2002), Piraeus, Attiki
University General Hospital of Heraklion-Internal Medicine-Oncology ( Site 2001), Heraklion, Irakleio
University General Hospital of Larissa-Oncology Clinic ( Site 2004), Larissa, Thessalia
European Interbalkan Medical Center ( Site 2007), Thessaloniki, Not set
Queen Mary Hospital ( Site 3400), Hksar, Not set
Hong Kong United Oncology Centre ( Site 3403), Kowloon, Not set
Queen Elizabeth Hospital ( Site 3402), Yau Ma Tei, Not set
Rambam Health Care Campus-Oncology Division ( Site 2203), Haifa, Not set
Shaare Zedek Medical Center ( Site 2206), Jerusalem, Not set
Rabin Medical Center ( Site 2204), Petah Tikva, Not set
Sheba Medical Center ( Site 2200), Ramat Gan, Not set
Humanitas Istituto Clinico Catanese ( Site 2315), Misterbianco, Catania
IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"-Oncologia Medica ( Site 2302), Meldola, Emilia-Romagna
Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 2300), Milan, Lombardia
Fondazione IRCCS San Gerardo dei Tintori-Oncologia ( Site 2301), Monza, Lombardia
Istituto Nazionale Tumori Regina Elena-Oncologia Medica 2 ( Site 2309), Rome, Roma
Azienda Ospedaliera Universitaria Careggi-SOD ONCOLOGIA MEDICA ( Site 2307), Firenze, Toscana
Humanitas Gavazzeni-ONCOLOGY ( Site 2310), Bergamo, Not set
Ospedale San Martino ( Site 2313), Genova, Not set
Ospedale San Raffaele-Oncologia Medica ( Site 2311), Milano, Not set
Azienda Ospedaliero Universitaria di Parma-UO Oncologia Medica ( Site 2312), Parma, Not set
Fondazione IRCCS Policlinico San Matteo-Oncology ( Site 2303), Pavia, Not set
Fondazione Policlinico Universitario Agostino Gemelli IRCCS -Medical Oncology ( Site 2306), Roma, Not set
APSS- Presidio Ospedaliero S. Chiara ( Site 2304), Trento, Not set
National Hospital Organization Shikoku Cancer Center ( Site 1216), Matsuyama, Ehime
Hospital of the University of Occupational and Environmental Health, Japan ( Site 1217), Kitakyushu, Fukuoka
Kobe City Medical Center General Hospital ( Site 1213), Kobe, Hyogo
St. Marianna University Hospital ( Site 1207), Kawasaki, Kanagawa
Kanagawa Cancer Center ( Site 1206), Yokohama, Kanagawa
Kansai Medical University Hospital ( Site 1211), Hirakata, Osaka
Kindai University Hospital ( Site 1212), Osakasayama, Osaka
Saitama Prefectural Cancer Center ( Site 1201), Kitaadachi-gun, Saitama
Juntendo University Hospital ( Site 1204), Bunkyo-ku, Tokyo
Tokyo Medical University Hospital ( Site 1203), Shinjuku, Tokyo
National Hospital Organization Kyushu Cancer Center ( Site 1218), Fukuoka, Not set
Fukushima Medical University Hospital ( Site 1200), Fukushima, Not set
Hiroshima University Hospital ( Site 1215), Hiroshima, Not set
Niigata Cancer Center Hospital ( Site 1208), Niigata, Not set
Okayama University Hospital ( Site 1214), Okayama, Not set
Osaka International Cancer Institute ( Site 1210), Osaka, Not set
Nippon Medical School Hospital ( Site 1205), Tokyo, Not set
Chungbuk National University Hospital-Internal medicine ( Site 1000), Cheongju-si, Chungbuk
National Cancer Center-Lung Cancer Center ( Site 1002), Goyang-si, Kyonggi-do
Seoul National University Bundang Hospital-Medical Oncology ( Site 1003), Seongnam, Kyonggi-do
The Catholic University Of Korea St. Vincent's Hospital-Medical Oncology ( Site 1001), Suwon-si, Kyonggi-do
Keimyung University Dongsan Hospital CRC room 1 ( Site 1006), Daegu, Taegu-Kwangyokshi
Asan Medical Center-Lung Cancer Center ( Site 1005), Seoul, Not set
Samsung Medical Center-Division of Hematology/Oncology ( Site 1004), Seoul, Not set
CIO - Centro de Inmuno-Oncología de Occidente ( Site 0506), Guadalajara, Jalisco
Centro de Investigacion Clinica de Oaxaca ( Site 0509), Oaxaca de Juarez, Oaxaca
Unidad de Mastologia Avanzada de Chihuahua S.A de C.V ( Site 0504), Chihuahua, Not set
Mediadvance Clinical ( Site 0502), Chihuahua, Not set
Oaxaca Site Management Organization S.C. ( Site 0507), Oaxaca, Not set
Amphia Ziekenhuis, locatie Breda Molengracht-long oncologie ( Site 3453), Breda, Noord-Brabant
Isala, locatie Zwolle-Poli Longziekten ( Site 3454), Zwolle, Overijssel
Meander Medisch Centrum-Researchbureau Longgeneeskunde ( Site 3458), Amersfoort, Utrecht
Erasmus Medisch Centrum ( Site 3452), Rotterdam, Zuid-Holland
University Medical Center Groningen ( Site 3459), Groningen, Not set
Sint Antonius Ziekenhuis ( Site 3455), Utrecht, Not set
Auckland City Hospital ( Site 0800), Auckland, Not set
Akershus Universitetssykehus ( Site 2501), Lørenskog, Akershus
Drammen Sykehus, Vestre Viken HF ( Site 2502), Drammen, Buskerud
Sykehuset Innlandet HF Gjøvik ( Site 2503), Gjøvik, Oppland
Oslo universitetssykehus HF. Radiumhospitalet ( Site 2504), Oslo, Not set
IPOR Instituto Peruano de Oncología & Radioterapia-Centro de Investigación ( Site 0604), Lima, Not set
Oncosalud ( Site 0602), Lima, Not set
INSTITUTO NACIONAL DE ENFERMEDADES NEOPLASICAS-Medical Oncology ( Site 0600), Lima, Not set
Instituto Neuro Cardiovascular de las Americas ( Site 0607), Lima, Not set
Hospital Nacional Edgardo Rebagliati Martins-medical oncology ( Site 0603), Lima, Not set
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworow Pluca i Klatki Pier ( Site 2600), Warszawa, Mazowieckie
Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu ( Site 2601), Przemysl, Podkarpackie
Bialostockie Centrum Onkologii ( Site 2604), Bialystok, Podlaskie
Uniwersyteckie Centrum Kliniczne ( Site 2610), Gdansk, Pomorskie
Szpital Specjalistyczny w Prabutach Spolka z o.o. ( Site 2613), Prabuty, Pomorskie
Warmińsko - Mazurskie Centrum Chorób Płuc w Olsztynie-Oddzial Onkologii z Pododdzialem Chemioterapii ( Site 2606), Olsztyn, Warminsko-mazurskie
Wielkopolskie Centrum Pulmonologii i Torakochirurgii-Oddzial Onkologii Klinicznej z Pododdzialem Dz ( Site 2602), Poznan, Wielkopolskie
UNIDADE LOCAL DE SAUDE DE MATOSINHOS-Serviço de Oncologia ( Site 2705), Matosinhos, Porto
Instituto Portugês de Oncologia de Coimbra Francisco Gentil-Oncologia Médica ( Site 2704), Coimbra, Not set
Instituto Português de Oncologia do Porto Francisco Gentil, EPE ( Site 2702), Porto, Not set
MEMORIAL HEALTHCARE INTERNATIONAL S.R.L.. ( Site 2803), Bucharest, Bucuresti
Spitalul Universitar de Urgență Elias ( Site 2804), București, Bucuresti
Cardiomed SRL Cluj-Napoca-Medical Oncology ( Site 2801), Cluj-Napoca, Cluj
SC Radiotherapy Center Cluj SRL-Oncologie Medicala ( Site 2802), Florești, Cluj
Centrul de Oncologie Sfantul Nectarie-Medical ( Site 2805), Craiova, Dolj
Spitalul Clinic Municipal De Urgenta Timisoara ( Site 2806), Timişoara, Timis
SC ONCO CARD SRL ( Site 2808), Brasov, Not set
Institut Català d'Oncologia - L'Hospitalet-Medical Oncology ( Site 2901), L Hospitalet, Barcelona
CHUS - Hospital Clinico Universitario-Servicio de Oncologia ( Site 2905), Santiago de Compostela, La Coruna
Hospital Insular de Gran Canaria-Oncology ( Site 2903), Las Palmas de Gran Canaria, Las Palmas
HOSPITAL UNIVERSITARIO QUIRONSALUD MADRID-ONCOLOGIA MEDICA ( Site 2902), Pozuelo de Alarcon, Madrid
Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 2900), Barcelona, Not set
Hospital Clinico San Carlos-Oncology Department ( Site 2904), Madrid, Not set
Kantonsspital Graubünden-Medizin ( Site 3006), Chur, Grisons
Kantonsspital Münsterlingen - Spital Thurgau AG ( Site 3005), Munsterlingen, Thurgau
CHUV (centre hospitalier universitaire vaudois) ( Site 3003), Lausanne, Vaud
HFR Fribourg - Hôpital Cantonal ( Site 3004), Fribourg, Not set
National Taiwan University Cancer Center (NTUCC) ( Site 1105), Taipei City, Taipei
Tri-Service General Hospital ( Site 1100), Taipei City, Taipei
Taoyuan General Hospital ( Site 1106), Taoyuan City, Taoyuan
Kaohsiung Medical University Chung-Ho Memorial Hospital ( Site 1103), Kaohsiung, Not set
Taichung Veterans General Hospital-Chest ( Site 1101), Taichung, Not set
National Cheng Kung University Hospital-Clinical Trial Center ( Site 1102), Tainan, Not set
National Taiwan University Hospital-Oncology ( Site 1104), Taipei, Not set
Adana Medical Park Seyhan Hastanesi-Medikal Onkoloji ( Site 3106), Adana, Not set
Gulhane Egitim Arastirma Hastanesi-Onkoloji ( Site 3104), Ankara, Not set
Hacettepe Universite Hastaneleri-oncology hospital ( Site 3101), Ankara, Not set
Memorial Ankara Hastanesi-Medical Oncology ( Site 3110), Ankara, Not set
Ankara Bilkent Şehir Hastanesi-Medical Oncology ( Site 3103), Ankara, Not set
TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 3107), Istanbul, Not set
Conditions: Non Small Cell Lung Cancer
A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure
Recruiting
This study is open to adults aged 18 or above legal age with heart failure. People can join the study if they have heart failure symptoms and a left ventricular ejection fraction (LVEF) of 40% or more. The purpose of this study is to find out whether vicadrostat (BI 690517) in combination with empagliflozin helps people with heart failure.
Participants are put into 2 groups by chance. Every participant has an equal chance of being in each group. The groups are:
* Vicadrostat and empagliflozin... Read More
This study is open to adults aged 18 or above legal age with heart failure. People can join the study if they have heart failure symptoms and a left ventricular ejection fraction (LVEF) of 40% or more. The purpose of this study is to find out whether vicadrostat (BI 690517) in combination with empagliflozin helps people with heart failure.
Participants are put into 2 groups by chance. Every participant has an equal chance of being in each group. The groups are:
* Vicadrostat and empagliflozin group: participants take vicadrostat and empagliflozin as tablets once a day.
* Placebo and empagliflozin group: participants take placebo and empagliflozin as tablets once a day.
Participants can stay in the study as long as they benefit from treatment and can tolerate it. During this time, they visit their doctors regularly. The doctors regularly check participants' health and take note of any unwanted effects. The study staff may also contact the participants by phone. Participants also regularly answer questions about their well-being.
The study does not have a fixed duration. It continues until there is enough data to see if the treatment is working. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/21/2025
Locations: Diagnostic and Medical Clinic, Mobile, Alabama +574 locations
Diagnostic and Medical Clinic, Mobile, Alabama
Mobile Heart Specialists, PC, Mobile, Alabama
Velocity Clinical Research-Chula Vista-67286, Chula Vista, California
University of California Irvine, Orange, California
North America Research Institute, San Dimas, California
Orange County Research Center, Tustin, California
Amicis Research Center (ARC), Valencia, California
Bridgeport Hospital, Bridgeport, Connecticut
Excel Medical Clinical Trials, Boca Raton, Florida
Bay Area Cardiology, Brandon, Florida
Clearwater Cardiovascular and Interventional Consultants, Clearwater, Florida
Cardiology Associates Research Co., Daytona Beach, Florida
Malcom Randall VA Medical Center, Gainesville, Florida
Velocity Clinical Research-Hallandale Beach-67888, Hallandale Beach, Florida
University of Florida Health Jacksonville, Jacksonville, Florida
East Coast Institute for Research, LLC-Jacksonville-55146, Jacksonville, Florida
First Coast Cardiovascular Institute, Jacksonville, Florida
Clearwater Cardiovascular Consultants-Largo-69917, Largo, Florida
University of Miami, Miami, Florida
Sacred Heart Medical Specialty Group, Miramar Beach, Florida
Advanced Research for Health Improvement, LLC, Naples, Florida
Southwest Florida Research, LLC, Naples, Florida
Ocala Cardiovascular Research, Ocala, Florida
Ocala Research Institute, Inc, Ocala, Florida
Charlotte Cardiovascular Institute, PA, Port Charlotte, Florida
East Coast Institute for Research, LLC-Saint Augustine-63032, Saint Augustine, Florida
University of South Florida, Tampa, Florida
Cardiology Partners Clinical Research Institute, Wellington, Florida
Cozy Research LLC, Wesley Chapel, Florida
Clinical Site Partners, LLC, Winter Park, Florida
Atlanta Clinical Research Centers, Atlanta, Georgia
Columbus Regional Research Institute, Columbus, Georgia
NSC Research Inc, Johns Creek, Georgia
Kootenai Medical Center, Coeur d'Alene, Idaho
Northwest Heart Clinical Research, LLC, Arlington Heights, Illinois
Illinois Masonic Hospital, Chicago, Illinois
Chicago Medical Research, Hazel Crest, Illinois
Clinical Investigation Specialists, Inc.-Libertyville-69941, Libertyville, Illinois
AMR Park Ridge, Park Ridge, Illinois
Midwest Cardiovascular Research and Education Foundation, Elkhart, Indiana
St. Francis Medical Group-Indiana Heart Physicians, Inc, Indianapolis, Indiana
Indiana Medical Research Institute, Merrillville, Indiana
Cardiovascular Research of Northwest Indiana, LLC, Munster, Indiana
Reid Hospital, Richmond, Indiana
The Iowa Clinic, PC, West Des Moines, Iowa
West Houston Area Clinical Trial Consultants, LLC, Wichita, Kansas
Norton Heart Specialists, Louisville, Kentucky
Grace Research, LLC-Bossier City-51040, Bossier City, Louisiana
Heart Clinic of Hammond, Hammond, Louisiana
Grace Research, LLC-Shreveport-64616, Shreveport, Louisiana
Louisiana Heart Center - Slidell, Slidell, Louisiana
Ascension Saint Agnes Heart Care, Baltimore, Maryland
AMR Dearborn, Dearborn, Michigan
Sparrow Clinical Research Institute, Lansing, Michigan
Trinity Health Michigan D/B/A Michigan Heart, Ypsilanti, Michigan
Minneapolis VA Health Care System, Minneapolis, Minnesota
Jackson Heart Clinic, P.A., Jackson, Mississippi
Kansas City VA Medical Center, Kansas City, Missouri
North Kansas City Hospital, North Kansas City, Missouri
St. Louis Heart and Vascular, P.C., Saint Louis, Missouri
Velocity Clinical Research-Lincoln-69943, Lincoln, Nebraska
Advanced Heart Care, LLC, Bridgewater, New Jersey
Garden State Heart Care, PC, Manalapan, New Jersey
Cardio Metabolic Institute, Somerset, New Jersey
Cardiac Care and Vascular Medicine, PLLC, Bronx, New York
NYU Langone Health, New York, New York
Mount Sinai Hospital-New York-52529, New York, New York
Medication Management, LLC, Greensboro, North Carolina
WakeMed, Raleigh, North Carolina
K and R Research LLC, Marion, Ohio
Mercy Health St. Vincent Medical Center, Toledo, Ohio
Bon Secours Medical Group Greenville Specialty Care, LLC, Greenville, South Carolina
Monument Health, Rapid City, South Dakota
Helios CR Inc, Jackson, Tennessee
East Coast Institute For Research LLC, Jefferson City, Tennessee
Pharmatex Research, Amarillo, Texas
Amarillo Heart Clinical Research Institute, Incorporated, Amarillo, Texas
Texas Health Research and Education Institute, Dallas, Texas
Texas Health Research and Education Institute, Dallas, Texas
Southwest Family Medicine Associates, Dallas, Texas
University of Texas Southwestern Medical Center, Dallas, Texas
Helios CR Inc, Fort Worth, Texas
Private Practice Leadership, LLC, Katy, Texas
Texas Cardiology Research Center PLLC, Kingwood, Texas
DCOL Center for Clinical Research, Longview, Texas
North Texas Research Associates, McKinney, Texas
Texas Institute Of Cardiology, McKinney, Texas
University of Utah Hospital, Salt Lake City, Utah
Carient Heart and Vascular, Manassas, Virginia
Sentara Norfolk General Hospital, Norfolk, Virginia
Selma Medical Associates, Winchester, Winchester, Virginia
Virginia Mason Medical Center, Seattle, Washington
Drug Research and Analysis Corporation, Madison, Wisconsin
ProHealth Care Research Institute and Cardiology Associates, Waukesha, Wisconsin
Inst de Inv Clinicas-Bahia Blanca, Bahia Blanca, Not set
Swiss Medical Center Barrio Parque, Buenos Aire, Not set
Centro de Investigaciones Metabolicas (CINME)-Ciudad Autonoma Buenos Aires-41221, Ciudad Autonoma Buenos Aires, Not set
Mautalen- Salud e Investigacion, Ciudad Autonoma Buenos Aires, Not set
Centro Medico Dra Laura Maffei, Ciudad Autonoma Buenos Aires, Not set
Fundacion Favaloro, Ciudad Autonoma Buenos Aires, Not set
Instituto Cardiovascular de Buenos Aires, Ciudad Autonoma Buenos Aires, Not set
Glenny Corp. S.A. Bioclinica Argentina, Ciudad Autonoma Buenos Aires, Not set
Centro Medico Viamonte, Ciudad Autonoma de Bs As, Not set
Hospital Italiano de Buenos Aires, Ciudad Autónoma de Bs As, Not set
Instituto Medico Elsa Perez SRL (IMEP), Ciudadela, Not set
Clinica Privada Colombo- Fundacion Clinica Colombo, Cordoba, Not set
Instituto Médico DAMIC S.R.L., Cordoba, Not set
Centro Medico Luquez, Cordoba, Not set
Clinica Coronel Suárez, Coronel Suarez, Not set
Sanatorio Allende S.A., Córdoba, Not set
Well Medica, Córdoba, Not set
Centro de Investigaciones Medicas Mar del Plata, Mar del Plata, Not set
Hospital Universitario Austral, Pilar, Not set
Instituto de Investigaciones Clínicas de Quilmes, Quilmes, Not set
DIM Clinica Privada, Ramos Mejía, Not set
Instituto de Investigaciones Clinicas de Rosario, Rosario, Not set
Instituto CAICI, Rosario, Not set
Centro Cardiovascular Salta, Salta, Not set
Corporacion Medica de Gral. San Martin S.A., San Martin, Not set
Investigaciones Clinicas Tucuman, San Miguel de Tucuman, Not set
Clinica Mayo, San Miguel de Tucuman, Not set
Instituto de Investigaciones Clinicas San Nicolas, San Nicolas, Not set
Centro de Investigaciones Clínicas del Litoral, Santa Fe, Not set
CEMEDIC - Centro de Especialidades Medicas, Villa Luro, Not set
Canberra Hospital, Garran, Australian Capital Territory
Concord Repatriation General Hospital, Concord, New South Wales
Gosford Hospital, Gosford, New South Wales
Nepean Hospital, Kingswood, New South Wales
Pendlebury Research, Kotara, New South Wales
Royal Brisbane and Women's Hospital, Brisbane, Queensland
Prince Charles Hospital, Chermside, Queensland
John Flynn Private Hospital, Tugun, Queensland
Royal Adelaide Hospital, Adelaide, South Australia
The Queen Elizabeth Hospital, Woodville, South Australia
Total Cardiovascular Care, Frankston, Victoria
Royal Melbourne Hospital, Parkville, Victoria
Mount Hospital, Perth, Western Australia
Ziekenhuis Oost-Limburg - Campus Sint-Jan, Genk, Not set
AZ Sint-Lucas - Campus Sint Lucas, Gent, Not set
Grand Hôpital de Charleroi, Gilly, Not set
Jessa Ziekenhuis, Hasselt, Not set
Kortrijk - HOSP AZ Groeninge Kennedylaan, Kortrijk, Not set
UZ Leuven, Leuven, Not set
Hospital Vera Cruz, Belo Horizonte, Not set
Cardresearch Cardiologia Assistencial e de Pesquisas Ltda, Belo Horizonte, Not set
L2IP -Instituto de Pesquisas Clínicas Ltda., Brasilia, Not set
CECAP - Centro de Cardiologia Clínica, Brasília, Not set
Hospital Angelina Caron, Campina Grande do Sul, Not set
IPECC - Instituto de Pesquisa Clínica de Campinas, Campinas, Not set
Centro Especializado em Cardiol Loema Instituto de Pesq Clin, Campinas, Not set
Hospital do Rocio, Campo Largo, Not set
PUC Trials - Núcleo de Pesquisa Clínica da Escola de Medicina da PUC-PR, Curitiba, Not set
Via Medica, Goiânia, Not set
ICM - Instituto do Coracao de Marilia, Marília, Not set
Instituto Mederi de Pesquisa e Saude, Passo Fundo, Not set
Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, Not set
Hospital de Clínicas de Porto Alegre, Porto Alegre, Not set
Universidade Federal do Rio Grande do Sul, Porto Alegre, Not set
Hospital Mae de Deus, Porto Alegre, Not set
Hospital das Clínicas FMRP-USP, Ribeirão Preto, Not set
Instituto Brasil de Pesquisa Clinica (IBPClin), Rio de Janeiro, Not set
Ruschel Medicina e Pesquisa Clínica, Rio Do Janeiro, Not set
Pesquisare, Santo Andre, Not set
Praxis Pesquisa Medica, Santo Andre, Not set
Fundacao Faculdade Regional de Medicina, Sao Jose, Sao Jose Rio Preto, Not set
Centro de Pesquisa Clinica - CPCLIN, Sao Paulo, Not set
CEPIC - Centro Paulista de Investigacao Clinica, Sao Paulo, Not set
CEDOES - Diagnóstico e Pesquisa,Vitória, Vitória, Not set
Integral Pesquisa e Ensino, Votuporanga, Not set
Ambulatory for Individual Practice for Specialized Medical Care in Cardiology - Dr Nikolay Iliev, Pleven, Not set
Medical Center Medconsult Pleven LTD, Pleven, Not set
Multiprofile Hospital for Active Treatment Heart and Brain EAD, Pleven, Not set
UMHAT Sv.Georgi, Plovdiv, Not set
National Multiprofile Transport Hospital, Sofia, Sofia, Not set
Diagnostic Consultative Center Alexandrovska, Sofia, Not set
University Multidisciplinary Hospital for Active Treatment Sveta Ekaterina EAD, Sofia, Not set
University Multiprofile Hospital for Active Treatement "Alexandrovska" EAD, Sofia, Not set
Medical Center Hera EOOD, Sofia, Not set
MHAT "Tsaritsa Yoanna-ISUL" Clinic of Cardiology, Sofia, Sofia, Not set
Multiprofile Hospital MHATEM 'Pirogov', Sofia, Sofia, Not set
Kalimat Medical Center Ltd., Sofia, Not set
Medical Center Zara-Med EOOD, Stara Zagora, Not set
DCC 'Chaika', EOOD, Varna, Varna, Not set
MHAT St Panteleimon, Yambol, Not set
MHAT St Panteleimon, Yambol, Not set
Cambridge Cardiac Care Centre, Cambridge, Ontario
Curnew Medicine Professional Corporation, Hamilton, Ontario
KMH Cardiology Centres (Mississauga), Mississauga, Ontario
Oakville Trafalgar Memorial Hospital, Oakville, Ontario
James Cha, MD, Oshawa, Ontario
Kawartha Cardiology Clinical Trials, Peterborough, Ontario
CardioQuest Research Centre, Sarnia, Ontario
KMH Cardiology Centers (Hamilton), Stoney Creek, Ontario
Diabetes Heart Research Centre, Toronto, Ontario
ViaCar Recherches Cliniques Inc. (Greenfield Park), Greenfield Park, Quebec
Jewish General Hospital, Montreal, Quebec
Diex Recherche (Trois-Rivieres), Trois-Rivières, Quebec
Royal Alexandra Hospital, Edmonton, Not set
Clinical Research Solutions Inc. (Kitchener), Kitchener, Not set
Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Not set
Montreal General Hospital - McGill University Health Centre, Montreal, Not set
CardioVasc HR Inc., St. Jean sur Richelieu, Not set
Health Sciences North, Sudbury, Not set
Quantum Research Santiago, Puerto Varas, Puerto Varas, Not set
Sociedad Medica Cardiologica El Llano, Santiago, Not set
Hospital Las Higueras, Talcahuano, Not set
CECMI Ltda, Temuco, Not set
CINVEC - Centro de Investigacion Clinica V Reg.,Vina del Mar, Viña del Mar, Not set
The First Affiliated Hospital of Baotou Medical College, Baotou, Not set
Baotou Central Hospital, Baotou, Not set
Beijing AnZhen Hospital, Beijing, Not set
Cardiovascular Institute and Fu Wai Hospital, Beijing, Not set
Peking University Third Hospital, Beijing, Not set
Jilin Province People's Hospital, Changchun, Not set
The First Hospital of Jilin University, Changchun, Not set
China-Japan Union Hospital of Jilin University, Changchun, Not set
Changde Second People's Hospital, Changde City, Not set
Changsha Central Hospital, Changsha, Not set
The Second Xiangya Hospital Of Central South University, Changsha, Not set
The third xiangya hospital of Central South University, Changsha, Not set
The Third Hospital of Changsha, Changsha, Not set
Chengdu Second People's Hospital, Chengdu, Not set
West China Hospital of Sichuan University, Chengdu, Not set
The First Affiliated Hospital of Chengdu Medical College, Chengdu, Not set
Chenzhou No.1 people's Hospital, Chenzhou, Not set
Affiliated Zhongshan Hospital of Dalian University, Dalian, Not set
Daqing Oilfield General Hospital, Daqing City, Not set
People's Hospital of Deyang City, Deyang, Not set
The First People's Hospital of Foshan, Foshan, Not set
The First Affiliated Hospital of Fujian Medical University, Fuzhou, Not set
No.900 Hospital of PLA Joint Logistics Support Force, Fuzhou, Not set
Guangdong Provincial People's Hospital, Guangzhou, Not set
Sun yet-sen Memorial Hospital, Sun yet-sen Univesity, Guangzhou, Not set
Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Not set
The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Not set
The Affiliated Panyu Central Hospital of Guangzhou Medical University, Guangzhou, Not set
The Affiliated Hospital of Guizhou Medical University, Guiyang City, Not set
Guizhou People's Hospital, Guiyang, Not set
Hainan General Hospital, Haikou, Not set
Hangzhou First People's Hospital, Hangzhou, Not set
The First Affiliated Hospital of Harbin Medical University, Harbin, Not set
Huainan First People's Hospital, Huainan, Not set
Jiangmen Central Hospital, Jiangmen, Not set
Center Hospital of Jinan, Jinan, Not set
Jining No.1 people's hospital, Jining, Not set
Lanzhou University Second Hospital, Lanzhou, Not set
Linfen Central Hospital, Linfen, Not set
The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Not set
Luoyang Third People's Hospital, Luoyang, Not set
The First Affiliated Hospital of Nanchang University, Nanchang City, Not set
Jiangxi Province Integrated Tractional Chinese Medicine& Western Medicine Hospital, Nanchang, Not set
Nanjing Drum Tower Hospital, Nanjing, Not set
Nanjing Jiangning Hospital, Nanjing, Not set
The First Affiliated Hospital of Guangxi Medical University, Nanning, Not set
Nanyang First People's Hospital, Nanyang, Not set
Nanyang Second General Hospital, Nanyang, Not set
Panjin Liao Oil Gem Flower Hospital, Panjin, Not set
Pingxiang People's Hospital, Pingxiang, Not set
Zhongshan Hospital Affiliated to Fudan University, Shanghai, Not set
Tongren hospital, Shanghai Jiaotong University School of Medicine, Shanghai, Not set
Shanghai General Hospital, Shanghai, Not set
Shengjing Hospital of China Medical University, Shengyang, Not set
Shenzhen People's Hospital, Shenzhen, Not set
The Second Hospital of Hebei Medical University, Shijiazhuang, Not set
Tianjin Union Medical Center Nankai University Affiliated Hospital, Tianjin, Not set
Hubei Province Zhongshan Hospital, Wuhan, Not set
Wuhan Puai Hospital, Wuhan, Not set
Renmin Hospital of Wuhan University, Wuhan, Not set
Shaanxi Provincial People's Hospital, XI An, Not set
Xiangtan Central Hospital, Xiangtan, Not set
The People's Hospital Of Xuancheng City, Xuancheng, Not set
The General Hospital of XZCMG (The Second Affiliated Hospital of Xuzhou Medical University), Xuzhou, Not set
Yanbian University Hospital, Yanji, Not set
The first People's Hosptal of Yinchuan, Yinchuan, Not set
Yueyang Central Hospital, Yueyang, Not set
Yuncheng Central Hospital, Yuncheng, Not set
The First Affiliated Hospital of Hebei North University, Zhangjiakoou, Not set
The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Not set
Affiliated Hospital of Jiangsu University, Zhenjiang, Not set
Cardiomet CEQUIN S.A.S, Armenia, Not set
IPS Centro Cientifico-Asistencial S.A.S, Barranquilla, Not set
Corazon IPS S.A.S., Barranquilla, Not set
Centro de Investigacion Medico Asistencial S.A.S, Barranquilla, Not set
IPS Centro Medico Julián Coronel S.A., Cali, Not set
Centro De Diagnostico Cardiologico Ltda, Cartagena, Not set
Fundacion Cardiovascular de Colombia, Floridablanca, Not set
IPS médicos internistas de Caldas S.A.S., Manizales, Not set
T Y C Inversiones S.A.S Grupsalud, Santa Marta, Not set
Healthy Medical Center S.A.S, Zipaquirá, Zipaquirá, Not set
Medicus Services Ltd., Brandys nad Labem, Not set
Interni Ordinace s.r.o., Brandýs nad Labem, Not set
University Hospital at St. Anna, Brno, Not set
Internal and Cardiology Practice, MUDr. Karel Kamenik, Brno, Brno, Not set
University Hospital Brno, Brno, Not set
Vojenska nemocnice Brno, Brno, Not set
Poliklinika Bílovec, Bílovec, Not set
MUDr. Jan Hubac, s.r.o. Kardiologicka ambulance, Chrudim, Not set
Regional Hospital Havlickuv Brod, Havlickuv Brod, Not set
Kardiologie KarMa s.r.o, Jablonec nad Nisou, Not set
Hospital Jihlava, Jihlava, Not set
MUDr Petra Maskova PhD, Litovel, Not set
InterKardioML s.r.o., Marianske Lazne, Not set
Cardiology and Angiology Private Practice, Prague 10, Not set
Motol University Hospital, Prag, Not set
Kardiologie Vinohrady s r o, Praha 1, Not set
Thomayer University Hospital, Praha 4-Krc, Not set
Institute for Clinical and Experimental Medicine -Praha 4-58982, Praha 4, Not set
Internist Care s r o, Smirice, Not set
Kardiologicka ambulance MUDr. Ferkl s.r.o., Trutnov, Not set
Clinical Trials Services s.r.o, Uherske Hradiste, Not set
MUDr. Nina Zemkova s.r.o., Uherske Hradiste, Not set
Cardio Research s.r.o., Zlin, Not set
Universitätsklinikum Aachen, AöR, Aachen, Not set
Klinikum am Plattenwald, Bad Friedrichshall, Not set
Praxis Dr. Rieker, Berlin, Berlin, Not set
Charite Universitätsmedizin Berlin KöR, Berlin, Not set
Praxis Dr. Toursarkissian, 13347 Berlin, Berlin, Not set
Charité Campus Virchow-Klinikum, Berlin, Not set
Vivantes Netzwerk für Gesundheit GmbH, Berlin, Not set
Vivantes Netzwerk für Gesundheit GmbH, Berlin, Not set
Universitätsklinikum Bonn AöR, Bonn, Not set
Praxis Dr. Menzel, Dessau-Roßlau, Not set
Städtisches Klinikum Dresden, Dresden, Not set
Helios Klinikum Erfurt, Erfurt, Not set
ClinPhenomics CVC GmbH, Frankfurt, Not set
Medizinische Hochschule Hannover, Hannover, Not set
Universitätsklinikum Jena, Jena, Not set
Praxis Joachim Heisters, Kamp-Lintfort, Not set
Asklepios Klinik Langen-Seligenstadt GmbH, Langen, Not set
Praxis Dr. Sarnighausen, Lüneburg, Lüneburg, Not set
Marienhaus Klinikum St. Elisabeth, Neuwied, Neuwied, Not set
Gemeinschaftspraxis Dres Haggenmiller/Jeserich, Nürnberg, Not set
Kardiologische Praxis Papenburg, Papenburg, Not set
Universitätsklinikum Regensburg, Regensburg, Not set
Gemeinschaftspraxis Stuhr-Brinkum, Stuhr, Not set
Praxis Dr. Großkopf Wilma, Wallerfing, Wallerfing, Not set
Kardiologische Praxis, Wermsdorf, Wermsdorf, Not set
Lausmed Kft. Outpatient Unit of Internal Medicine, Baja, Not set
Buda Hospital of the Hospitaller Order of Saint John of God, Budapest, Not set
Obuda Health Center, Budapest, Not set
Belvaros-Lipotvaros Egeszsegugyi Szolgalat, Budapest, Not set
Semmelweis University, Budapest, Not set
Gottsegen National Cardiovascular Center, Budapest, Not set
Semmelweis University, Budapest, Not set
Privat Doktor Egeszseguegyi Szolgaltato Zrt., Budapest, Not set
UNO Medical Trials Kft., Budapest, Not set
Bekes Varmegyei Koezponti Korhaz, Gyula, Not set
BKS Research Ltd, Hatvan, Not set
Borsod-Abauj-Zemplen Megyei Korhaz es Egyetemi Oktato Korhaz, Miskolc, Not set
IPR Hungary Kft., Miskolc, Not set
Dr. Nagy Laszlo Kardiologiai Maganrendeles, Oroshaza, Not set
Coromed-Smo Kft., Pecs, Not set
Pécsi Tudományegyetem Klinikai Központ, Pecs, Not set
Da Vinci Private Clinic, Pecs, Not set
Ujszeged Egeszsegkozpont Diabetes Centrum, Szeged, Not set
Tolna County Balassa Janos Hospital, Szekszard, Not set
Jasz-Nagykun-Szolnok Megyei Hetenyi G. Korhaz-Rendelointezet, Szolnok, Not set
Belvarosi Egeszseghaz Kft., Zalaegerszeg, Not set
Kamalnayan Bajaj Hospital, Aurangabad, Not set
Narayana Institute of Cardiac Sciences, Bangalore, Not set
Bangalore Medical college, Bengaluru, Not set
S.P. Medical College & Associated Group of Hospitals, Bikaner, Not set
Tamil Nadu Government Multi Super Speciality Hospital TNGMSSH, Chennai, Not set
Apollo Main Hospital, Chennai, Not set
Medanta-The Medicity, Gurgaon, Not set
GNRC Hospital, Guwahati, Not set
IPGMER and SSKM Hospital, Kolkata, Not set
Max Super Speciality Hospital, Delhi, New Delhi, Not set
King George Hospital, Vishakhapatnam, Not set
Humanitas Gavazzeni, Bergamo, Not set
ASST Papa Giovanni XXIII, Bergamo, Not set
Az.Osp. Universitaria "Ospedali Riuniti", Foggia, Not set
Azienda Ospedaliera San Martino, Genova, Not set
Azienda Ospedaliera Universitaria "Federico II", Napoli, Not set
Fondazione IRCCS Policlinico S. Matteo, Pavia, Not set
Azienda Ospedaliera Sant'Andrea-Università di Roma La Sapienza, Roma, Not set
Istituto Clinico Humanitas, Rozzano, Not set
Kasugai Municipal Hospital, Aichi, Kasugai, Not set
Azumino Red Cross Hospital, Azumino-shi, Not set
Chiba Heart Clinic, Chiba, Chiba, Not set
Tokyo-Eki Center-building Clinic, Chuo-Ku, Not set
Kokura Memorial Hospital, Fukuoka, Kitakyushu, Not set
National Hospital Organization Hamada Medical Center, Hamada-shi, Not set
NHO Mito Medical Center, Higashiibaraki-gun, Not set
Hyogo Prefectural Harima-Himeji General Medical Center, Himeji-shi, Not set
Matsuda Cardiovascular Clinic, Hokkaido, Sapporo, Not set
Oji General Hospital, Hokkaido, Tomakomai, Not set
Hyogo Prefectural Amagasaki General Medical Center, Hyogo, Amagasaki, Not set
National Hospital Organization Kanazawa Medical Center, Ishikawa, Kanazawa, Not set
National Hospital Organization Iwakuni Clinical Center, Iwakuni-shi, Not set
Kagawa Prefectural Central Hospital, Kagawa, Takamatsu, Not set
Tokushukai Shonan Kamakura General Hospital, Kamakura-shi, Not set
Tokushukai Hayama Heart Center, Kanagawa, Miura-gun, Not set
Kanagawa Cardiovascular and Respiratory Center, Kanagawa, Yokohama, Not set
Yokohama Sakae Kyosai Hospital, Kanagawa, Yokohama, Not set
Mitoyo General Hospital, Kanonji-shi, Not set
Tokushukai Kishiwada Tokushukai Hospital, Kishiwada-shi, Not set
North Alps Medical Center Azumi Hospital, Kitaazumi-gun, Not set
National Hospital Organization Kobe Medical Center, Kobe-shi, Not set
Shinshu University Hospital, Matsumoto-shi, Not set
Ehime Prefectural Central Hospital, Matsuyama-shi, Not set
Matsuyama Shimin Hospital, Matsuyama-shi, Not set
Mito Saiseikai General Hospital, Mito-shi, Not set
Hokushin General Hospital, Nakano-shi, Not set
NHO Oita Medical Center, Oita-shi, Not set
Okayama City General Medical Center Okayama City Hospital, Okayama, Okayama, Not set
Naha City Hospital, Okinawa, Naha, Not set
Urasoe General Hospital, Okinawa, Urasoe, Not set
Kitano Hospital, Osaka, Osaka, Not set
Osaka Keisatsu Hospital, Osaka, Osaka, Not set
Nippon Life Hospital, Osaka, Osaka, Not set
Japan Community Health care Organization Osaka Hospital, Osaka, Osaka, Not set
Osaka General Medical Center, Osaka, Osaka, Not set
Saga-Ken Medical Centre Koseikan, Saga-shi, Not set
Sainokuni Higashiomiya Medical Center, Saitama-shi, Not set
San-Ai Hospital, Saitama-shi, Not set
NHO Sendai Medical Center, Sendai-shi, Not set
The University of Osaka Hospital, Suita-shi, Not set
Tokushima Prefectural Central Hospital, Tokushima-shi, Not set
Ome Municipal General Hospital, Tokyo, Ome, Not set
Tomakomai City Hospital, Tomakomai-shi, Not set
Inje University Busan Paik Hospital, Busan, Not set
Dong-A University Hospital, Busan, Not set
Pusan National Univ. Hosp, Busan, Not set
Chonnam National University Hospital, Gwangju, Not set
Gachon University Gil Medical Center, Incheon, Not set
Seoul National University Bundang Hospital, Seongnam, Not set
Seoul National University Hospital, Seoul, Not set
Severance Hospital, Seoul, Not set
Samsung Medical Center, Seoul, Not set
Korea University Guro Hospital, Seoul, Not set
Yonsei University Wonju Severance Christian Hospital, Wonju-si, Gangwon State, Not set
Fundación Cardiovascular de Aguascalientes A.C, Aguascalientes, Not set
Hospital Cardiologica Aguascalientes, Aguascalientes, Not set
Centro Medico Culiacán, Culiacan, Not set
Centro de Investigacion Biomedica y Farmaceutica, S.C., Distrito Federal, Not set
CICEJ Centro de Investigacion Clinica Endocrinologica de Jalisco S.C., Guadalajara, Not set
Salud Cardiovascular, Guadalajara, Not set
Proactive CR Mexico S.A. de C.V., Irapuato, Not set
Cardiolink Clin Trials S.C., Monterrey, Not set
Hospital Universitario Dr Jose Eleuterio Gonzalez, Monterrey, Not set
Clinstile S.A. de C.V., México, Not set
Clinical Research Institute S.C., Tlalnepantla, Not set
Centro de Investigacion Medica Alberto Bazzoni S.A. de C.V., Torreon, Not set
Rijnstate Hospital, Arnhem, Not set
Amphia Ziekenhuis, Breda, Not set
Deventer Ziekenhuis, Deventer, Not set
Catharina Ziekenhuis, Eindhoven, Not set
Groene Hart ziekenhuis, Gouda, Not set
Alrijne Leiderdorp, Leiderdorp, Not set
St. Antonius ziekenhuis, locatie Nieuwegein, Nieuwegein, Not set
Ikazia Ziekenhuis, Rotterdam, Not set
Jeroen Bosch Ziekenhuis-Hertogenbosch, s Hertogenbosch, Not set
De Heel - Zaans Medisch Centrum, Zaandam, Not set
Univ. Clinic Hosp, Bialystok, Bialystok, Not set
INTERCORE Medical Center, Bydgoszcz, Not set
NZOZ Medical Center KERmed, Bydgoszcz, Not set
Poradnia Kardiologiczna Jaroslaw Jurowiecki, Gdansk, Not set
Individual Specialist Medical Practice Krzysztof Cymerman, Gdynia, Not set
Pratia Katowice Medical Center, Katowice, Not set
Clinical Medical Research Sp. z o.o., Katowice, Not set
Specialistic Cardiology&Hypertension Out-patient Clin,Kielce, Kielce, Not set
Leszek Bryniarski Specialized Medical Cabinet, Krakow, Not set
Linden Sp. z o.o. sp.k., Kraków, Not set
Beata Miklaszewicz & Dariusz Dabrowski Cardiamed Sp. j., Legnica, Not set
SANTA FAMILIA Centrum Badan, Profilaktyki i Leczenia, Lodz, Not set
Individual Specialized Practice, Lodz, Not set
Lowickie Cardiology Center, Lowicz, Not set
Velocity Lublin, Lublin, Not set
Zanamed Medical Clinic Sp. z o.o., Lublin, Not set
Medeusz-Plus, Olsztyn, Not set
Medicome Sp. z o.o., Oswiecim, Not set
NZOZ HEUREKA, Piaseczno, Piaseczno, Not set
Non-Public Outpatient Clinic Neuro-Kard Ilkowski & Partners, Poznan, Not set
Aka-Med Centrum Sp. z o.o. S.K., Ruda Slaska, Not set
MEDYK Medical Center, Rzeszow, Not set
Lukmed Lukasz Wozniak, Siedlce, Not set
Velocity Skierniewice Sp. z o.o, Skierniewice, Not set
RCMed- Regionalne Centrum Medyczne, Sochaczew, Not set
NZOZ Procordis, Cardiology Research Center of Sopot, Sopot, Not set
Velocity Staszow, Staszow, Not set
FutureMeds Sp. z o.o., Warsaw, Not set
Balsammedica Sp. z o. o., Warszawa, Not set
4. Military Clinical Hospital with Polyclinic SP ZOZ, Wroclaw, Not set
Sedimed Sp. z o.o., Wroclaw, Not set
KO-MED Clinical Centers Zamosc, Zamosc, Not set
NZOZ Centrum Medyczne SERAFIN-MED Halina Serafin, Zarow, Not set
Spitalul Clinic De Urgenta Prof Dr Agrippa Ionescu, Balotesti, Not set
Spitalul Judetean de Urgenta Braila, Braila, Not set
S.C.Centrul Medical Unirea SRL, Brasov, Not set
S.C. Policlinica CCBR S.R.L., Bucharest, Not set
Emergency University Hospital, Bucharest, Bucharest, Not set
Clinica Medicala Data Plus SRL, Bucuresti, Not set
Spitalul Angiocare SRL, Cluj-Napoca, Not set
S.C.Centrul Medical Unirea S.R.L., Iasi, Not set
Sal Med Srl, Pitesti, Not set
Cmi Dr. Podoleanu Cristian, Targu Mures, Not set
Country Clinical Emergency Hospital, Targu-Mures, Targu-Mures, Not set
S.C Medicali's S.R.L, Timisoara, Not set
King AbdulAziz University Hospital, Jeddah, Not set
King Faisal Specialist Hospital and Research Center, Riyadh, Not set
King Abdulaziz Medical City, Riyadh, Not set
King Fahad Medical City, Riyadh, Not set
King Saud Medical City, Riyadh, Not set
Clinical Hospital Center Dr. Dragisa Misovic, Belgrade, Not set
Institute for Cardiovascular diseases Dedinje, Belgrade, Not set
University Clinical Center of Serbia, Belgrade, Not set
Clinical Hospital Center Zemun, Belgrade, Not set
University Clinical Center of Kragujevac, Kragujevac, Not set
Institute for Treatment and Rehabilitation, Niska Banja, Niska Banja, Not set
University Clinical Center Nis, Nis, Not set
General Hospital Pancevo, Pancevo, Not set
General Hospital Sveti Luka, Smederevo, Not set
Health Centre Zajecar, Zajecar, Not set
General Hospital Celje, Celje, Not set
University Hospital Golnik, Golnik, Not set
General Hospital Jesenice, Jesenice, Not set
University Medical Center Ljubljana, Ljubljana, Not set
General Hospital Murska Sobota, Murska Sobota, Not set
General Hospital Trbovlje, Trbovlje, Not set
Iatros International, Bloemfontein, Not set
Josha Research Centre, Bloemfontein, Not set
TREAD Research, Cape Town, Not set
Badenhorst, JCW, Centurion, Not set
Chris Hani Baragwanath Hospital: Cardiology Department, Johannesburg, Not set
Dr JM Engelbrecht, Somerset West, Not set
Clinical Projects Research, Worcester, Not set
Hospital Quiron. I.C.U., Barcelona, Not set
Hospital Universitario Virgen de la Arrixaca, El Palmar, Not set
Hospital General Universitario Gregorio Marañón, Madrid, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
Hospital La Paz, Madrid, Not set
Hospital Virgen de la Victoria, Malaga, Not set
Hospital Virgen del Camino, Sanlúcar de Barrameda, Not set
Complexo Hospitalario Universitario De Santiago, Santiago de Compostela, Not set
Hospital Clínico de Valencia, Valencia, Not set
Hospital General Universitario de Valencia, Valencia, Not set
Hospital Politècnic La Fe, Valencia, Not set
Hospital Virgen de las Montañas, Villamartin, Villamartin, Cardiz, Not set
E-Da Hospital, Kaohsiung, Not set
China Medical University Hospital, Taichung, Not set
Taichung Veterans General Hospital, Taichung, Not set
Taipei Medical University Hospital, Taipei City, Not set
National Taiwan University Hospital, Taipei, Not set
Taipei Veterans General Hospital, Taipei, Not set
Cheng Hsin General Hospital, Taipei, Not set
Chang Gung Memorial Hospital(Linkou), Taoyuan County, Not set
Çukurova Ü. Tip Fak., Balcali Hastanesi, Kardiyoloji, Adana, Not set
Afyon Kocatepe University Medical Faculty, Afyon, Not set
Etlik City Hospital, Ankara, Not set
Firat University Hospital, Elazıg, Not set
Ataturk Universitesi Tip Fakultesi, Erzurum, Not set
Osmangazi Uni Medical Faculty, Eskisehir, Not set
Gaziantep University Medical Faculty Sahinbey Educational Research Hospital, Gaziantep, Not set
Siyami Ersek Gogus Kalp ve Damar Cerrahisi Hastanesi, Istanbul, Not set
Marmara University Pendik Training and Research Hospital, Istanbul, Not set
Medical Park Pendik Hospital, Istanbul, Not set
Kutahya Health Science University, Kutahya, Not set
Inonu Universitesi Tip Fakultesi Gogus Hastaliklari ABD, Malatya, Not set
Mersin University Medical Faculty, Mersin, Not set
KTU Tip Fakultesi Farabi Hastanesi, Trabzon, Not set
Barnet Hospital, Barnet, Not set
Southmead Hospital, Bristol, Not set
Royal Devon and Exeter Hospital, Wonford, Exeter, Not set
Calderdale Royal Hospital, Halifax, Not set
St Bartholomew's Hospital, London, Not set
The Royal Oldham Hospital, Oldham, Not set
Northern General Hospital, Sheffield, Not set
Royal Cornwall Hospital, Truro, Not set
York and Scarborough Teaching Hospitals NHS Foundation Trust York Hospital, York, Not set
Bach Mai hospital, Hanoi, Not set
Cho Ray Hospital, Ho Chi Minh City, Not set
Nguyen Tri Phuong Hospital, Ho Chi Minh City, Not set
Tam Duc Heart Hospital, Ho Chi Minh, Not set
Thong Nhat Hospital HCMC, Ho Chi Minh, Not set
Conditions: Heart Failure
A Study With Tovorafenib (DAY101) as a Treatment Option for Progressive, Relapsed, or Refractory Langerhans Cell Histiocytosis
Recruiting
This phase II trial tests the safety, side effects, best dose and activity of tovorafenib (DAY101) in treating patients with Langerhans cell histiocytosis that is growing, spreading, or getting worse (progressive), has come back (relapsed) after previous treatment, or does not respond to therapy (refractory). Langerhans cell histiocytosis is a type of disease that occurs when the body makes too many immature Langerhans cells (a type of white blood cell). When these cells build up, they can form... Read More
This phase II trial tests the safety, side effects, best dose and activity of tovorafenib (DAY101) in treating patients with Langerhans cell histiocytosis that is growing, spreading, or getting worse (progressive), has come back (relapsed) after previous treatment, or does not respond to therapy (refractory). Langerhans cell histiocytosis is a type of disease that occurs when the body makes too many immature Langerhans cells (a type of white blood cell). When these cells build up, they can form tumors in certain tissues and organs including bones, skin, lungs and pituitary gland and can damage them. This tumor is more common in children and young adults. DAY101 may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Using DAY101 may be effective in treating patients with relapsed or refractory Langerhans cell histiocytosis. Read Less
Gender:
ALL
Ages:
Between 180 days and 22 years
Trial Updated:
08/21/2025
Locations: Children's Hospital of Alabama, Birmingham, Alabama +103 locations
Children's Hospital of Alabama, Birmingham, Alabama
Arkansas Children's Hospital, Little Rock, Arkansas
Kaiser Permanente Downey Medical Center, Downey, California
Loma Linda University Medical Center, Loma Linda, California
Children's Hospital Los Angeles, Los Angeles, California
Valley Children's Hospital, Madera, California
UCSF Benioff Children's Hospital Oakland, Oakland, California
Kaiser Permanente-Oakland, Oakland, California
Children's Hospital of Orange County, Orange, California
Lucile Packard Children's Hospital Stanford University, Palo Alto, California
UCSF Medical Center-Mission Bay, San Francisco, California
Children's Hospital Colorado, Aurora, Colorado
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center, Denver, Colorado
Connecticut Children's Medical Center, Hartford, Connecticut
Yale University, New Haven, Connecticut
Alfred I duPont Hospital for Children, Wilmington, Delaware
Children's National Medical Center, Washington, District of Columbia
Golisano Children's Hospital of Southwest Florida, Fort Myers, Florida
University of Florida Health Science Center - Gainesville, Gainesville, Florida
Nemours Children's Clinic-Jacksonville, Jacksonville, Florida
Nicklaus Children's Hospital, Miami, Florida
Arnold Palmer Hospital for Children, Orlando, Florida
Nemours Children's Hospital, Orlando, Florida
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa, Florida
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia
Memorial Health University Medical Center, Savannah, Georgia
Lurie Children's Hospital-Chicago, Chicago, Illinois
University of Chicago Comprehensive Cancer Center, Chicago, Illinois
Saint Jude Midwest Affiliate, Peoria, Illinois
Riley Hospital for Children, Indianapolis, Indiana
Blank Children's Hospital, Des Moines, Iowa
University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa
University of Kentucky/Markey Cancer Center, Lexington, Kentucky
Children's Hospital New Orleans, New Orleans, Louisiana
Sinai Hospital of Baltimore, Baltimore, Maryland
Michigan State University, East Lansing, Michigan
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids, Michigan
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis, Minnesota
University of Minnesota/Masonic Cancer Center, Minneapolis, Minnesota
University of Mississippi Medical Center, Jackson, Mississippi
Cardinal Glennon Children's Medical Center, Saint Louis, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Mercy Hospital Saint Louis, Saint Louis, Missouri
Children's Hospital and Medical Center of Omaha, Omaha, Nebraska
University of Nebraska Medical Center, Omaha, Nebraska
Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas, Nevada
Summerlin Hospital Medical Center, Las Vegas, Nevada
Hackensack University Medical Center, Hackensack, New Jersey
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick, New Jersey
Saint Joseph's Regional Medical Center, Paterson, New Jersey
Albany Medical Center, Albany, New York
Montefiore Medical Center - Moses Campus, Bronx, New York
Maimonides Medical Center, Brooklyn, New York
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York
Memorial Sloan Kettering Cancer Center, New York, New York
NYP/Weill Cornell Medical Center, New York, New York
New York Medical College, Valhalla, New York
Mission Hospital, Asheville, North Carolina
Duke University Medical Center, Durham, North Carolina
East Carolina University, Greenville, North Carolina
Wake Forest University Health Sciences, Winston-Salem, North Carolina
Rainbow Babies and Childrens Hospital, Cleveland, Ohio
Nationwide Children's Hospital, Columbus, Ohio
Dayton Children's Hospital, Dayton, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Oregon Health and Science University, Portland, Oregon
Geisinger Medical Center, Danville, Pennsylvania
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Saint Christopher's Hospital for Children, Philadelphia, Pennsylvania
Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
Prisma Health Richland Hospital, Columbia, South Carolina
BI-LO Charities Children's Cancer Center, Greenville, South Carolina
East Tennessee Childrens Hospital, Knoxville, Tennessee
The Children's Hospital at TriStar Centennial, Nashville, Tennessee
Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee
Dell Children's Medical Center of Central Texas, Austin, Texas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas
El Paso Children's Hospital, El Paso, Texas
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas
M D Anderson Cancer Center, Houston, Texas
Children's Hospital of San Antonio, San Antonio, Texas
Methodist Children's Hospital of South Texas, San Antonio, Texas
University of Texas Health Science Center at San Antonio, San Antonio, Texas
Scott and White Memorial Hospital, Temple, Texas
Primary Children's Hospital, Salt Lake City, Utah
University of Virginia Cancer Center, Charlottesville, Virginia
Children's Hospital of The King's Daughters, Norfolk, Virginia
VCU Massey Comprehensive Cancer Center, Richmond, Virginia
Seattle Children's Hospital, Seattle, Washington
Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington
West Virginia University Charleston Division, Charleston, West Virginia
Sydney Children's Hospital, Randwick, New South Wales
Queensland Children's Hospital, South Brisbane, Queensland
Perth Children's Hospital, Perth, Western Australia
University of Alberta Hospital, Edmonton, Alberta
IWK Health Centre, Halifax, Nova Scotia
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton, Ontario
Children's Hospital, London, Ontario
Hospital for Sick Children, Toronto, Ontario
Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke, Quebec
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Quebec, Not set
Conditions: Recurrent Langerhans Cell Histiocytosis, Refractory Langerhans Cell Histiocytosis
A Study of CT-388 in Participants Who Are Overweight or Obese With Type 2 Diabetes Mellitus
Recruiting
This is a multi-center, randomized, double-blind, placebo-controlled, parallel group dose-finding study to evaluate the efficacy and safety of CT-388 at low, middle, and high doses in participants who are overweight or obese with Type 2 diabetes mellitus (T2DM).
This is a multi-center, randomized, double-blind, placebo-controlled, parallel group dose-finding study to evaluate the efficacy and safety of CT-388 at low, middle, and high doses in participants who are overweight or obese with Type 2 diabetes mellitus (T2DM). Read Less
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
08/21/2025
Locations: Pinnacle Research Group, Llc; Central, Anniston, Alabama +83 locations
Pinnacle Research Group, Llc; Central, Anniston, Alabama
Central Alabama Research, Birmingham, Alabama
University of Alabama at Birmingham (UAB), Birmingham, Alabama
Alabama Clinical Therapeutics, Birmingham, Alabama
Lakeview Clinical Research, LLC, Guntersville, Alabama
Synexus - Clinical Research Advantage - Central Phoenix Medical Clinic LLC, Phoenix, Arizona
Yuma Clinical Trials, Yuma, Arizona
AMCR Institute, Escondido, California
Orange Country Research Center, Lake Forest, California
Ark Clinical Research, Long Beach, California
Catalina Research Institute, LLC, Montclair, California
Asclepes Research Centers, Sherman Oaks, California
Encompass Clinical Research, Spring Valley, California
Flourish Research - Boca Raton, Boca Raton, Florida
Tampa Bay Medical Research, Clearwater, Florida
ASCLEPES Research Centers, Lutz, Florida
K2 Medical Research, LLC - Maitland, Maitland, Florida
K2 Medical Research, LLC - Orlando, Maitland, Florida
Flourish Research Acquisition, LLC, Miami, Florida
K2 Medical Research, LLC - South Orlando, Orlando, Florida
Aging Well Associates, Saint Petersburg, Florida
K2 Medical Research Tampa, Tampa, Florida
K2 Summit Research, The Villages, Florida
Privia Medical Group Georgia, LLC, Fayetteville, Georgia
Javara Inc. /Privia Medical Group Georgia, LLC, Richmond Hill, Georgia
Privia Medical Group Georgia - Thomasville, Thomasville, Georgia
Rophe Adult and Pediatric Medicine/SKYCRNG, Union City, Georgia
Duly Health and Care, Lombard, Illinois
McFarland Clinic, Ames, Iowa
Cotton O'Neil Clinical Research Center, Topeka, Kansas
NOLA Cares, LLC, Metairie, Louisiana
Flourish Research Acquisition, LLC dba Flourish Bowie, Bowie, Maryland
Centennial Medical Group, Elkridge, Maryland
NECCR PrimaCare Research LLC, Fall River, Massachusetts
Ahmed Arif Medical Research Center (AA MRC LLC), Flint, Michigan
Prime Health and Wellness, Fayette, Mississippi
Olive Branch Family Medical Center; Family Medicine, Olive Branch, Mississippi
SKY Integrative Medical Center/SKYCRNG, Ridgeland, Mississippi
University of Nebraska Medical Center, Omaha, Nebraska
Ellipsis Research Group, Brooklyn, New York
Accellacare of Cary, Cary, North Carolina
Accellacare - Hickory, Hickory, North Carolina
Accellacare of Rocky Mount, Rocky Mount, North Carolina
Accellacare of Piedmont Healthcare, Statesville, North Carolina
Accellacare of Wilmington, LLC, Wilmington, North Carolina
Accellacare Research of Winston Salem, Winston-Salem, North Carolina
Diabetes and Endocrinology Associates of Stark County, Inc., Canton, Ohio
Tekton Research, Edmond, Oklahoma
Alliance for Multispecialty Research, LLC (AMR Norman), Norman, Oklahoma
Roper St. Francis Physician Partners - Primary Care, Mount Pleasant, South Carolina
Internal Medicine and Pediatrics Associates of Bristol; PMG Research of Bristol, Bristol, Tennessee
Accellacare - Knoxville, Jefferson, Tennessee
Norwood Family Medicine, Knoxville, Tennessee
Summit-Halls Family Practice, Knoxville, Tennessee
Clinical Research Associates, Nashville, Tennessee
FutureSearch Trials of Neurology, Austin, Texas
Velocity Clinical Research - Dallas, Dallas, Texas
University of Texas Southwestern Medical Center Investigation Drug Services, Dallas, Texas
Juno Research, LLC, Houston, Texas
Consano Clinical Research, Shavano Park, Texas
Privia Medical Group North Texas - Stephenville, Stephenville, Texas
Manassas Clinical Research Center, Manassas, Virginia
Centro Medico Viamonte SRL, Buenos Aires, Provincia De Buenos
Centricity Research Brampton Endocrinology, Brampton, Ontario
Aggarwal and Associates, Brampton, Ontario
Centricity Research Oshawa Multispecialty, Oshawa, Ontario
LMC Clinical Research Inc, Toronto, Ontario
CEMDEC S.A. de C.V., Cuauhtemoc, Not set
Instituto de Diabetes Obesidad y Nutricion, SC, Cuernavaca, Not set
SINACOR, Culiacan, Not set
Medical Care and Research S.A de C.V, Merida, Not set
Centro De Investigacion En Artritis Y Osteopososis, Mexicali, Not set
Clinicos Asociados Bocm, S.C., Mexico City, Not set
Avant Santé Research Center, San Pedro Garza García, Not set
Sociedad de Metabolismo y Corazon S.C., Veracruz, Not set
FAICIC S de R.L. de C.V, Veracruz, Not set
Optimal Clinical Trials - North, Rosedale, Auckland
New Zealand Clinical Research - Auckland, Auckland, Not set
Momentum Pukekohe, Auckland, Not set
New Zealand Clinical Research - Christchurch, Christchurch, Not set
Optimal Clinical Trials, Grafton, Not set
Tauranga Hospital, Tauranga, Not set
Momentum Wellington, Wellington, Not set
ISIS Clinical Research Center, Guaynabo, Not set
Conditions: Overweight or Obese, Type 2 Diabetes Mellitus (T2DM)
Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.
Recruiting
Multi-center, global, prospective, non-randomized, interventional, pre-market trial. All subjects enrolled with receive the study device.
Multi-center, global, prospective, non-randomized, interventional, pre-market trial. All subjects enrolled with receive the study device. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/21/2025
Locations: University of Alabama Birmingham (UAB), Birmingham, Alabama +84 locations
University of Alabama Birmingham (UAB), Birmingham, Alabama
Abrazo Heart Hospital, Phoenix, Arizona
Scripps Memorial Hospital, La Jolla, California
PIH Health Good Samaritan Hospital, Los Angeles, California
Kaiser Permanente Los Angeles Medical Center, Los Angeles, California
Keck Hospital of the University of Southern California, Los Angeles, California
Cedars Sinai Medical Center, Los Angeles, California
El Camino, Mountain View, California
Kaiser Permanente San Francisco Medical Center, San Francisco, California
Stanford Hospital and Clinics, Stanford, California
Los Robles Regional Medical Center, Thousand Oaks, California
Hartford Hospital, Hartford, Connecticut
Yale New Haven Hospital, New Haven, Connecticut
MedStar Washington Hospital Center, Washington, District of Columbia
JFK Medical Center, Atlantis, Florida
Morton Plant, Clearwater, Florida
HealthPark Medical Center, Fort Myers, Florida
North Florida Regional Medical Center, Gainesville, Florida
Baptist Medical Center Jacksonville, Jacksonville, Florida
University of South Florida, Tampa, Florida
Emory University, Atlanta, Georgia
Piedmont Atlanta Hospital, Atlanta, Georgia
Northwestern Memorial Hospital, Chicago, Illinois
Rush University Medical Center, Chicago, Illinois
Mercy Medical Center, Des Moines, Iowa
The University of Kansas Hospital, Kansas City, Kansas
University of Maryland Medical Center, Baltimore, Maryland
The Johns Hopkins Hospital, Baltimore, Maryland
Massachusetts General Hospital, Boston, Massachusetts
Brigham and Women's Hospital, Boston, Massachusetts
Beth Israel Deaconess Medical Center, Boston, Massachusetts
University of Michigan Health System, Ann Arbor, Michigan
Henry Ford Saint John Hospital, Detroit, Michigan
Corewell Health, Grand Rapids, Michigan
Abbott Northwestern Hospital, Minneapolis, Minnesota
M Health Fairview University of Minnesota Medical Center - East Bank, Minneapolis, Minnesota
Barnes-Jewish Hospital, Saint Louis, Missouri
Providence St Patrick, Missoula, Montana
Morristown Medical Center, Morristown, New Jersey
Jersey Shore University Medical Center, Neptune, New Jersey
North Shore University Hospital, Manhasset, New York
NYU Langone Hospital - Long Island, Mineola, New York
NYU Langone Medical Center, New York, New York
The Mount Sinai Hospital, New York, New York
New York-Presbyterian Hospital Columbia University Medical Center, New York, New York
Montefiore Medical Center, New York, New York
Saint Francis Hospital, Roslyn, New York
Duke University Medical Center, Durham, North Carolina
The Christ Hospital, Cincinnati, Ohio
University Hospitals Cleveland Medical Center, Cleveland, Ohio
The Ohio State University Wexner Medical Center, Columbus, Ohio
OhioHealth Riverside Methodist Hospital, Columbus, Ohio
INTEGRIS Baptist Medical Center, Oklahoma City, Oklahoma
Providence Saint Vincent Medical Center, Portland, Oregon
Oregon Health and Science University, Portland, Oregon
UPMC Pinnacle Harrisburg Campus, Harrisburg, Pennsylvania
University of Pittsburgh Medical Center UPMC Presbyterian, Pittsburgh, Pennsylvania
Lankenau Medical Center, Wynnewood, Pennsylvania
Vanderbilt University Medical Center, Nashville, Tennessee
Heart Hospital of Austin, Austin, Texas
Texas Health Presbyterian Hospital Dallas, Dallas, Texas
Baylor Jack and Jane Hamilton Heart and Vascular Hospital, Dallas, Texas
CHI Saint Luke's Health-Baylor Saint Luke's Medical Center, Houston, Texas
Houston Methodist Hospital, Houston, Texas
The University of Texas Health Science Center at Houston, Houston, Texas
Baylor Scott & White Health (The Heart Hospital Baylor Plano), Plano, Texas
Methodist Hospital, San Antonio, Texas
The University of Vermont Medical Center, Burlington, Vermont
University of Virginia Medical Center, Charlottesville, Virginia
Inova Fairfax Hospital, Fairfax, Virginia
Sentara Norfolk General Hospital, Norfolk, Virginia
Saint Mary's Hospital/Bon Secours, Richmond, Virginia
Carilion Roanoke Memorial Hospital, Roanoke, Virginia
Winchester Medical Center, Winchester, Virginia
The Swedish Medical Center Cherry Hill, Seattle, Washington
University of Washington, Seattle, Washington
Providence Sacred Heart Medical Center & Children's Hospital, Spokane, Washington
Aurora St. Luke's Medical Center, Milwaukee, Wisconsin
Royal Columbian Hospital, New Westminster, British Columbia
St. Paul's Hospital, Vancouver, British Columbia
Sunnybrook Health Sciences Centre, Toronto, Ontario
St. Michael's Hospital, Toronto, Ontario
Montreal Heart Insitute, Montreal, Quebec
Glen Royal Victoria Hospital, Montreal, Quebec
Rigshospitalet, Copenhagen, Not set
Conditions: Mitral Valve Regurgitation
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