There are currently 70 active clinical trials seeking participants for Obstructive Sleep Apnea research studies. The states with the highest number of trials for Obstructive Sleep Apnea participants are California, Ohio, Florida and Pennsylvania.
Effect of CPAP on Blood Pressure in Excessively Sleepy Obstructive Sleep Apnea Subtype
Recruiting
The primary objective of this study is to determine the longer-term (6 months) effect of CPAP therapy on change in 24-hour mean blood pressure (24hMBP) in OSA subjects with the excessively sleepy symptom subtype.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
08/08/2025
Locations: The Ohio State University - Martha Morehouse Medical Pavilion, Suite 2600, Columbus, Ohio +1 locations
Conditions: Obstructive Sleep Apnea
MicroRNAs as Biomarkers for Obstructive Sleep Apnea
Recruiting
Although obstructive sleep apnea (OSA) is a common disorder, there are no blood biomarkers for identification and management of these patients. This project will study microRNAs in order to develop and validate blood biomarkers that are specific to OSA, useful for identification of cases with OSA, reflective of efficacy of therapy, and able to predict blood pressure response to treatment of OSA.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
07/15/2025
Locations: The Ohio State University - Martha Morehouse Medical Pavilion, Suite 2600, Columbus, Ohio +2 locations
Conditions: Obstructive Sleep Apnea
Improving Outcomes in Pediatric Obstructive Sleep Apnea With Computational Fluid Dynamics
Recruiting
To create a validated computational tool to predict surgical outcomes for pediatric patients with obstructive sleep apnea (OSA). The first line of treatment for children with OSA is to remove their tonsils and adenoids; however, these surgeries do not always cure the patient. Another treatment, continuous positive airway pressure (CPAP) is only tolerated by 50% of children. Therefore, many children undergo surgical interventions aimed at soft tissue structures surrounding the airway, such as ton... Read More
Gender:
ALL
Ages:
Between 3 years and 18 years
Trial Updated:
11/18/2024
Locations: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Conditions: Obstructive Sleep Apnea
PAP for Children With DS and OSAS
Recruiting
Determine the efficacy of family-informed intervention (INT) vs standard clinical care over a period of twelve months in children with obstructive sleep apnea and Down Syndrome.
Gender:
ALL
Ages:
Between 6 years and 18 years
Trial Updated:
08/11/2025
Locations: University of Miami, Miami, Florida +2 locations
Conditions: Down Syndrome, Obstructive Sleep Apnea
DISE: Phenotyping Obstruction Patterns
Recruiting
Drug-induced sleep endoscopy (DISE) represents an opportunity to evaluate the upper airway in sleep-like conditions. In its current clinical form, however, DISE does not routinely determine the functional impact of anatomic and neuromuscular factors on airflow obstruction. The investigators will apply nasal pressure (CPAP) during DISE to generate pressure-flow and pressure-area relationships, deriving functional determinants of upper airway obstruction during sleep. In addition, they will use o... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/08/2025
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Obstructive Sleep Apnea
Evaluating the Genetics and Immunology of Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) Syndrome and Other Tonsil Disorders
Recruiting
Background: Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) is the most common periodic fever syndrome of childhood. Symptoms can include swelling of the glands in the throat, mouth ulcers, and tonsillitis. Removal of the tonsils can stop the periodic flareups. But researchers do not know how PFAPA develops. In this natural history study, researchers will collect specimens and data from people with PFAPA to see what they might have in common. Objective: To coll... Read More
Gender:
ALL
Ages:
Between 1 month and 99 years
Trial Updated:
07/31/2025
Locations: Children's National Medical Center, Washington, District of Columbia +2 locations
Conditions: Periodic Fever, Aphthous Stomatitis, Pharyngitis, And Cervical Adenitis (Pfapa), Obstructive Sleep Apnea, Tonsillitis, Tonsil Disorder, Sleep Disordered Breathing
Alesis OSA-1 Obstructive Sleep Apnea Treatment
Recruiting
The goal of randomized clinical trial is to determine if the Alesis OSA-1 low laser light therapy device can reduce apnea-hypopnea index scores and treat sleep apnea in adult participants over the age of 18 who are diagnosed with obstructive sleep apnea (OSA). The main questions it aims to answer are\]: • Does the use of the Alesis OSA-1 device reduce the number of AHI events after six treatments of 12 minutes each, 2x per week x 3 weeks, in adult OSA patients? Researchers will compare results... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/23/2025
Locations: JD Medical Group, LLC, Miami, Florida +1 locations
Conditions: Obstructive Sleep Apnea
A Study to Assess the Efficacy and Safety of Lorundrostat in Participants With Obstructive Sleep Apnea and Hypertension
Recruiting
The primary purpose of the study is to assess the effect of lorundrostat taken orally (po) once a day on the Apnea-Hypopnea Index (AHI) in participants with moderate to severe obstructive sleep apnea (OSA) and hypertension.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
07/18/2025
Locations: The University of Alabama, Tuscaloosa, Alabama +26 locations
Conditions: Obstructive Sleep Apnea, Hypertension
Cardiometabolic Risk Effects of Short-term Cessation of Neurostimulation Therapy
Recruiting
Hypoglossal nerve stimulation (HGNS) is an implantable therapy that treats obstructive sleep apnea. The study will evaluate the effect of this treatment on cardiovascular and metabolism-related measures to see if it affects patients' risk of medical problems associated with obstructive sleep apnea (OSA).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/05/2025
Locations: Columbia University Medical Center, New York, New York
Conditions: Obstructive Sleep Apnea, Obstructive Sleep Apnea of Adult
Functional Improvement in OSA and COPD With a Telehealth LifeStyle and Exercise Intervention
Recruiting
The investigators will conduct a Type I hybrid effectiveness-implementation study to test an integrated telehealth intervention among 400 overweight and obese patients with Chronic Obstructive Pulmonary Disease (COPD) and Obstructive Sleep Apnea (OSA). The investigators will include eligible participants receiving primary care at one of five Department of Veterans Affairs (VA) medical centers and their community-based outpatient clinics. The investigators will randomize patients in a 1:1 ratio t... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/27/2025
Locations: Boise VA Medical Center, Boise, Idaho +4 locations
Conditions: Chronic Obstructive Pulmonary Disease, Obstructive Sleep Apnea, Overweight and Obesity
Endotypic Traits and Obstructive Sleep Apnea Surgery
Recruiting
This study will examine factors associated with outcomes after soft palate surgery and medications (acetazolamide, eszopiclone) that may treat other potential causes of obstructive sleep apnea (loop gain, arousal threshold).
Gender:
ALL
Ages:
21 years and above
Trial Updated:
06/26/2025
Locations: UCLA Santa Monica Medical Center, Santa Monica, California +1 locations
Conditions: Obstructive Sleep Apnea
Smart Pillows for Enhancing Sleep Quality
Recruiting
The purpose of this study is to examine the impact of smart pillows on the sleep quality of individuals who experience a snoring issue and/or obstructive sleep apnea (OSA), as well as their sleep partners. Furthermore, this study will explore whether enhancements in sleep quality positively influence depressive symptoms, physical activity, heart rate, blood oxygen levels, and cognitive functions.
Gender:
ALL
Ages:
50 years and above
Trial Updated:
06/26/2025
Locations: Indiana University, Indianapolis, Indiana
Conditions: Snoring, Obstructive Sleep Apnea