There are currently 82 active clinical trials seeking participants for Obstructive Sleep Apnea research studies. The states with the highest number of trials for Obstructive Sleep Apnea participants are California, Ohio, Florida and Pennsylvania.
MicroRNAs as Biomarkers for Obstructive Sleep Apnea
NCT06189755
Recruiting
Although obstructive sleep apnea (OSA) is a common disorder, there are no blood biomarkers for identification and management of these patients. This project will study microRNAs in order to develop and validate blood biomarkers that are specific to OSA, useful for identification of cases with OSA, reflective of efficacy of therapy, and able to predict blood pressure response to treatment of OSA.
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
05/07/2024
Locations: The Ohio State University - Martha Morehouse Medical Pavilion, Suite 2600, Columbus, Ohio +2 locations
Conditions: Obstructive Sleep Apnea
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Motivational Enhancement - Acute Decompensated Heart Failure and OSA
NCT04752462
Recruiting
A feasibility randomized controlled trial will be conducted with a 6-month follow up to: Examine the impact of early intensive telemedicine motivational enhancement (TIME) vs standard of care on PAP adherence (n=40/group) and continuity of care at 3 and 6 months post-discharge in patients admitted with ADHF with a new inpatient diagnosis of OSA(REI>5). Assess the effect of early telemedicine integrated with motivational enhancement (TIME) vs standard of care on patient reported outcomes includin... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/09/2024
Locations: Cleveland Clinic Foundation, Cleveland, Ohio
Conditions: Acute Decompensated Heart Failure, Obstructive Sleep Apnea, Motivational Enhancement, PAP Adherence
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Effect of CPAP on Blood Pressure in Excessively Sleepy Obstructive Sleep Apnea Subtype
NCT05742360
Recruiting
The primary objective of this study is to determine the longer-term (6 months) effect of CPAP therapy on change in 24-hour mean blood pressure (24hMBP) in OSA subjects with the excessively sleepy symptom subtype.
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
04/03/2024
Locations: The Ohio State University - Martha Morehouse Medical Pavilion, Suite 2600, Columbus, Ohio +1 locations
Conditions: Obstructive Sleep Apnea
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Improving Outcomes in Pediatric Obstructive Sleep Apnea With Computational Fluid Dynamics
NCT04991389
Recruiting
To create a validated computational tool to predict surgical outcomes for pediatric patients with obstructive sleep apnea (OSA). The first line of treatment for children with OSA is to remove their tonsils and adenoids; however, these surgeries do not always cure the patient. Another treatment, continuous positive airway pressure (CPAP) is only tolerated by 50% of children. Therefore, many children undergo surgical interventions aimed at soft tissue structures surrounding the airway, such as ton... Read More
Gender:
All
Ages:
Between 3 years and 18 years
Trial Updated:
10/23/2023
Locations: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Conditions: Obstructive Sleep Apnea
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Obstructive Sleep Apnea (OSA) and Sex-Specific Responses to N-acetylcysteine (NAC)
NCT06311045
Recruiting
This is a randomized controlled trial (RCT) of 4 weeks of study supplement N-acetylcysteine (NAC) versus placebo in persons with significant obstructive sleep apnea (OSA) who are receiving positive airway pressure therapy (PAP), the standard of care therapy. The purpose of the study is to determine if NAC is associated with sex-specific changes in overnight oxidative stress, inflammation, as well as endothelial dysfunction in persons with OSA.
Gender:
All
Ages:
Between 55 years and 75 years
Trial Updated:
06/20/2024
Locations: NYU Langone Health, New York, New York
Conditions: Obstructive Sleep Apnea
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TipTraQ Home Sleep Test Validation Study
NCT06351878
Recruiting
A validation study has been designed to assess the performance of a home sleep test device, TipTraQ, for screening sleep apnea. The study involves participants wearing the TipTraQ device on their fingertip during a traditional sleep test, known as polysomnography (PSG), conducted in a sleep center. The performance of the device will then be evaluated by comparing the results from the TipTraQ system with those from the traditional sleep test.
Gender:
All
Ages:
20 years and above
Trial Updated:
06/19/2024
Locations: Duke University, Durham, North Carolina
Conditions: Obstructive Sleep Apnea
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A Study of Retatrutide (LY3437943) in Participants With Type 2 Diabetes Mellitus Who Have Obesity or Overweight
NCT05929079
Recruiting
The purpose of this study is to is to evaluate the efficacy and safety of retatrutide in participants with type 2 diabetes in participants who have obesity or overweight (J1I-MC-GZBK master protocol) including a subset of participants who have obstructive sleep apnea (OSA) (J1I-MC-GSA2). The study will last about 89 weeks and will include up to 24 visits.
Gender:
All
Ages:
18 years and above
Trial Updated:
06/17/2024
Locations: Pinnacle Research Group, LLC, Anniston, Alabama +102 locations
Conditions: Type 2 Diabetes, Obesity, Overweight, Obstructive Sleep Apnea
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Restoring Metabolic and Reproductive Health With Sleep in PCOS Study, CPAP Trial
NCT05920694
Recruiting
In this study, the researchers are trying to learn more about the relationship between Polycystic Ovary Syndrome and Obstructive Sleep Apnea (OSA). Obstructive Sleep Apnea is a sleep-related breathing disorder that involves a decrease or complete stop in airflow. The purpose of this study is to find out why some people with obstructive sleep apnea have higher levels of insulin resistance, and the investigators will study the role of hypoxia (low levels of oxygen in the blood at night) in insulin... Read More
Gender:
Female
Ages:
Between 18 years and 40 years
Trial Updated:
06/17/2024
Locations: University of California, San Francisco, San Francisco, California
Conditions: Polycystic Ovary Syndrome, Obstructive Sleep Apnea
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A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight
NCT05929066
Recruiting
The purpose of this study is to evaluate the efficacy and safety of retatrutide in participants who have obesity or overweight (J1I-MC-GZBJ master protocol) including subsets of participants who have knee osteoarthritis (OA) (J1I-MC-GOA1) or who have obstructive sleep apnea (OSA) (J1I-MC-GSA1). This study will last about 89 weeks and will include up to 24 visits.
Gender:
All
Ages:
18 years and above
Trial Updated:
06/17/2024
Locations: Central Phoenix Medical Clinic, Phoenix, Arizona +138 locations
Conditions: Obesity, Overweight, Knee Pain Chronic, Knee Osteoarthritis, Obstructive Sleep Apnea
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A Study of Sex Differences in Neurocirculatory Control
NCT06261034
Recruiting
The purpose of this study is to investigate potential sex differences in neurocirculatory control of blood pressure in patients with untreated obstructive sleep apnea (OSA).
Gender:
All
Ages:
Between 20 years and 70 years
Trial Updated:
06/07/2024
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Obstructive Sleep Apnea
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Whole Food Plant-based Diet Effect on Obstructive Sleep Apnea
NCT06395181
Recruiting
This research aims to develop a better understanding and clinical knowledge of the effects of a plant based diet on severity and daytime sleepiness in Obstructive Sleep Apnea.
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
06/04/2024
Locations: Mayo Clinic Florida, Jacksonville, Florida
Conditions: Obstructive Sleep Apnea, Daytime Sleepiness
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Rescue Pharmacotherapy for OSA
NCT05293600
Recruiting
Persistent obstructive sleep apnea (OSA) is common in people treated with mandibular advancement device (MAD) or hypoglossal nerve stimulation (HGNS). For most patients, these treatments are the last line of defense. If MAD or HGNS do not work, then patients are left to suffer the consequences of undertreated OSA. In this study, the investigators want to test the addition of a drug treatment to their regimen. Endotypes will be targeted pharmacologically with one of the following drugs: acetazola... Read More
Gender:
All
Ages:
Between 21 years and 70 years
Trial Updated:
06/03/2024
Locations: Sleep Disorders Research Program Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Obstructive Sleep Apnea
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