There are currently 49 active clinical trials seeking participants for Amyotrophic Lateral Sclerosis research studies. The states with the highest number of trials for Amyotrophic Lateral Sclerosis participants are California, Florida, Pennsylvania and New York.
AIM's Writing for Healing: A Workshop for Individuals Living With Paralysis
NCT04721717
Recruiting
The UAB Institute for Arts In Medicine (AIM) is currently implementing an expressive emotional writing pilot project for adults with paralysis caused by neurological conditions such as traumatic head or spinal cord injury.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/19/2024
Locations: 354 School of Health Professions Building, Birmingham, Alabama
Conditions: Spinal Cord Injuries, Multiple Sclerosis, Transverse Myelitis, Amyotrophic Lateral Sclerosis
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Studies in Amyotrophic Lateral Sclerosis (ALS) and Other Neurodegenerative Motor Neuron Disorders
NCT05474235
Recruiting
The purpose of this study is to collect, from patients with sporadic and familial ALS and their family members, clinical data and blood samples for extraction of DNA, RNA, preparation of lymphocytes, plasma and serum to establish a repository for future investigations of genetic contributions to ALS pathogenesis. Blood samples for DNA extraction also would be collected from control subjects with no personal or family history of ALS phenotypes.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/13/2024
Locations: Mayo Clinic Florida, Jacksonville, Florida
Conditions: Amyotrophic Lateral Sclerosis
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Intermuscular Coherence as a Biomarker for ALS
NCT05104710
Recruiting
The specific aims of this study are to: 1. Determine if a painless and quick measurement of muscle activity using surface electrodes can help with the diagnosis of ALS. Specifically, we ask if a measure of intermuscular coherence (IMC-βγ), when added to current diagnostic criteria (Awaji criteria), can differentiate ALS from mimic diseases more accurately and earlier than currently possible. 2. Characterize IMC-βγ in neurotypical subjects by age, sex, race, and ethnicity. 3. Follow a cohort of... Read More
Gender:
ALL
Ages:
Between 20 years and 90 years
Trial Updated:
08/02/2024
Locations: University of California Center for Clinical Research, Irvine, California +3 locations
Conditions: Amyotrophic Lateral Sclerosis
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Digital Assessment of Speech and Fine Motor Control in ALS
NCT06315673
Recruiting
This is a single-session, case-control study that incorporates digital tools for assessing speech and motor function in motor neuron disease. Patients with motor neuron disease (including amyotrophic lateral sclerosis (ALS), primary lateral sclerosis (PLS), and progressive muscular atrophy (PMA)) and age-matched healthy controls will be enrolled. Subjects will complete a speech and handwriting assessment during the study visit on a tablet computer (BioSensics LLC, Newton, MA). We will explore wh... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/01/2024
Locations: Milton S. Hershey Medical Center, Hershey, Pennsylvania
Conditions: Amyotrophic Lateral Sclerosis, Primary Lateral Sclerosis, Progressive Muscular Atrophy
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Investigation on the Cortical Communication (CortiCom) System
NCT03567213
Recruiting
The CortiCom system consists of 510(k)-cleared components: platinum PMT subdural cortical electrode grids, a Blackrock Microsystems patient pedestal, and an external NeuroPort Neural Signal Processor. Up to two grids will be implanted in the brain, for a total channel count of up to 128 channels, for six months. In each participant, the grid(s) will be implanted over areas of cortex that encode speech and upper extremity movement.
Gender:
ALL
Ages:
Between 22 years and 70 years
Trial Updated:
07/01/2024
Locations: Johns Hopkins Medicine, Baltimore, Maryland
Conditions: Tetraplegia, Locked-in Syndrome, Brainstem Stroke, Amyotrophic Lateral Sclerosis
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The National Amyotrophic Lateral Sclerosis Registry
NCT01772602
Recruiting
The purpose of this registry is to (A) better describe the incidence and prevalence of Amyotrophic Lateral Sclerosis (ALS) in the United States;(B) examine appropriate factors, such as environmental and occupational, that may be associated with the disease; (C) better outline key demographic factors (such as age, race or ethnicity, gender, and family history of individuals who are diagnosed with the disease) associated with the disease; and (D) better examine the connection between ALS and other... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/06/2024
Locations: CDC, Atlanta, Georgia
Conditions: Amyotrophic Lateral Sclerosis
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CNS10-NPC-GDNF Delivered to the Motor Cortex for ALS
NCT05306457
Recruiting
The investigator is examining the safety of transplanting cells, that have been engineered to produce a growth factor, into the motor cortex (brain) of patients with Amyotrophic Lateral Sclerosis (ALS). The cells are called neural progenitor cells, which are a type of stem cell that can become several different types of cells in the nervous system. These cells have been derived to specifically become astrocytes, which is a type of neural cell. The growth factor is called glial cell line-derived... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/05/2024
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Amyotrophic Lateral Sclerosis
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A Mindful Community for People With ALS and Their Primary Caregivers
NCT05595850
Recruiting
The psychological impact of ALS on patients and caregivers is high, significantly affecting their quality of life (QOL). Despite this impact, there is not much research about psychological interventions that could reduce psychological distress and improve QOL. The efficacy of mindfulness-based treatments for the improvement of QOL was previously demonstrated by the investigator's group. Despite preliminary positive results, treatment efficacy tends to weaken over time. The investigators believe... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/13/2024
Locations: Harvard University, Cambridge, Massachusetts
Conditions: Amyotrophic Lateral Sclerosis, Caregiver Burden
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PatientSpot Formerly Known as ArthritisPower
NCT03840928
Recruiting
Patient Power is a patient research network and database (registry) to collect prospective information about demographics, self-reported diagnoses and medications, and willingness to participate in research from participants with rheumatoid arthritis (RA), spondyloarthritis (SpA), other musculoskeletal conditions, chronic neurological conditions like migraine, chronic pulmonary conditions like Chronic Obstructive Pulmonary Disease (COPD), asthma, autoimmune dermatological conditions such as psor... Read More
Gender:
ALL
Ages:
19 years and above
Trial Updated:
12/12/2023
Locations: Global Healthy Living Foundation, Upper Nyack, New York
Conditions: Rheumatoid Arthritis, Ankylosing Spondylitis, Fibromyalgia, Gout, Crohn Disease, Juvenile Idiopathic Arthritis, Lupus Erythematosus, Myositis, Osteoarthritis, Osteoporosis, Psoriasis, Psoriatic Arthritis, Scleroderma, Dermatomyositis, Inflammatory Bowel Diseases, Polymyositis, Axial Spondyloarthritis, Diffuse Idiopathic Skeletal Hyperostosis, Polymyalgia Rheumatica, Giant Cell Arteritis, Temporal Arteritis, Wegener, Relapsing Polychondritis, Undifferentiated Connective Tissue Disease, Spinal Cord Injuries, Alzheimer Disease, Amyotrophic Lateral Sclerosis, Ataxia, Bell Palsy, Brain Tumor, Cerebral Aneurysm, Epilepsy, Guillain-Barre Syndrome, Headache, Head Injury, Hydrocephalus, Lumbar Disc Disease, Meningitis, Multiple Sclerosis, Muscular Dystrophy, Neurocutaneous Syndromes, Parkinson Disease, Stroke, Cluster Headache, Tension-Type Headache, Chronic Obstructive Pulmonary Disease, Asthma, Lung Cancer, Cystic Fibrosis, Sleep Apnea, Eczema, Alopecia, Chronic Inflammation, Unstable Angina, Heart Attack, Heart Failure, Arrythmia, Valve Heart Disease, High Blood Pressure, Congenital Heart Disease, Peripheral Arterial Disease, Diabetes, Chronic Liver Disease, Obesity
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A Longitudinal Analysis of Biomarkers in Patients With ALS
NCT05309408
Recruiting
Longitudinally collect biomarkers from patients with amyotrophic lateral sclerosis (ALS) and control participants in order to further elucidate both potential causes and treatments for ALS. Samples and clinical information will be collected from patients with ALS and controls.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/21/2023
Locations: Holy Cross Hospital, Fort Lauderdale, Florida
Conditions: Amyotrophic Lateral Sclerosis
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Telehealth Implementation of Brain-Computer Interface
NCT05951556
Recruiting
Determine if Telehealth intervention can allow/empower a caregiver (who is untrained) to effectively implement and utilize a Brain-Computer Interface for communication with a participant who is "Locked in" following progression of Amyotrophic Lateral Sclerosis and other conditions.
Gender:
ALL
Ages:
Between 16 years and 100 years
Trial Updated:
07/18/2023
Locations: ShirleyRyan AbilityLab, Chicago, Illinois
Conditions: Amyotrophic Lateral Sclerosis, Stroke
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NuroSleeve Powered Brace & Stimulation System to Restore Arm Function
NCT04798378
Recruiting
The purpose of this study is to investigate if a person with weakness or paralysis in one or both arms, can use the NuroSleeve combined powered arm brace (orthosis) and muscle stimulation system to help restore movement in one arm sufficient to perform daily activities. This study could lead to the development of a product that could allow people with arm weakness or arm paralysis to use the NuroSleeve and similar devices to improve arm health and independent function.
Gender:
ALL
Ages:
4 years and above
Trial Updated:
04/11/2023
Locations: Nemours Children's Hospital, Wilmington, Delaware +1 locations
Conditions: Neurologic Diseases, Hemiparesis, Quadriplegia, Muscular Dystrophies, Arthrogryposis, Spinal Cord Injuries, Charcot-Marie-Tooth, Stroke, Weakness of Extremities as Sequela of Stroke, Weakness Due to Upper Motor Neuron Dysfunction, Amyotrophic Lateral Sclerosis, Spinal Muscular Atrophy, Arm Paralysis, Cerebral Palsy
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