There are currently 74 active clinical trials seeking participants for Atrial Fibrillation research studies. The states with the highest number of trials for Atrial Fibrillation participants are Florida, California, Ontario and Texas.
The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial Fibrillation
NCT05836987
Recruiting
REACT-AF is a multicenter prospective, randomized, open-label, blinded endpoint (PROBE design), controlled trial comparing the current Standard Of Care (SOC) of continuous Direct Oral Anticoagulation (DOAC) use versus time-delimited (1 month) DOAC guided by an AF-sensing Smart Watch (AFSW) in participants with a history of paroxysmal or persistent Atrial Fibrillation (AF) and low-to-moderate stroke risk.
Gender:
ALL
Ages:
Between 22 years and 85 years
Trial Updated:
08/07/2025
Locations: Banner University, Phoenix, Arizona +83 locations
Conditions: Atrial Fibrillation
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Prevention of Postoperative Atrial Fibrillation (POAF) Using Intra-Pericardial Amiodarone
NCT06063538
Recruiting
The purpose of this study is to evaluate the combination of CardiaMend, with the addition of amiodarone in the prevention of postoperative atrial fibrillation (POAF) in patients undergoing cardiac arterial bypass grafting (CABG) or valve surgery.
Gender:
ALL
Ages:
Between 20 years and 85 years
Trial Updated:
08/06/2025
Locations: The University of Chicago, Chicago, Illinois
Conditions: Atrial Fibrillation, Post-Op Complication
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Semaglutide for Metabolic Intervention and Adipose Loss to Treat Atrial Fibrillation
NCT06499857
Recruiting
The goal of the study is to learn how a weight loss medication called semaglutide, which is used to treat obesity, in addition to standard AF treatment might affect AF, atrial fibrillation severity, and whether it changes the risk of atrial fibrillation recurring after standard AF treatments.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
08/01/2025
Locations: The University of Arizona College of Medicine- Phoenix, Phoenix, Arizona +1 locations
Conditions: Overweight or Obesity, Atrial Fibrillation
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PULSED AF Post-Approval Study
NCT06578104
Recruiting
PULSED AF PAS is a prospective, global, multi-center, non-randomized, observational trial. Subjects will be treated with the PulseSelect™ PFA System and followed through 36 months.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/17/2025
Locations: Pikeville Medical Center, Whitesburg, Kentucky +10 locations
Conditions: Atrial Fibrillation
Register for Updates
The Fourth Left Atrial Appendage Occlusion Study
NCT05963698
Recruiting
LAAOS-4 aims to determine if catheter-based endovascular left atrial appendage occlusion prevents ischemic stroke or systemic embolism in participants with atrial fibrillation, who remain at high risk of stroke, despite receiving ongoing treatment with oral anticoagulation.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/09/2025
Locations: Affinity Hospital dba Grandview Medical Center, Birmingham, Alabama +63 locations
Conditions: Atrial Fibrillation, Stroke, Ischemic, Systemic Embolism
Register for Updates
Pericardiotomy in Cardiac Surgery
NCT06486636
Recruiting
PRINCE is an international, multicentre, randomized controlled trial of posterior pericardiotomy in patients without a history of atrial fibrillation (AF) or flutter undergoing cardiac surgery.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/09/2025
Locations: Weill Cornell Medicine, New York, New York +3 locations
Conditions: Atrial Fibrillation, Atrial Flutter, Cardiac Events
Register for Updates
Safety and Efficacy of Workflows of High Volume Single Operators in a LAAO Device Implant Procedural Day
NCT06436924
Recruiting
SAFE HV is an observational, prospective, multi-center, non-randomized study evaluating real-world clinical experience of centers where a single procedural physician schedules eight or more left atrial appendage occlusion (LAAO) device implant procedures in a single calendar day.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/08/2025
Locations: Grandview Medical Center, Birmingham, Alabama +6 locations
Conditions: Atrial Fibrillation
Register for Updates
Clinical and Healthcare Outcomes From Real-World Use in the United States of a Companion AI During AF Ablation
NCT06056271
Recruiting
Observational, multi-center, clinical device registry for US patients with a primary goal to observe the clinical outcomes in patients who are mapped with Volta Medical's VX1 or AF-Explorer systems during AF ablation procedures.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
06/30/2025
Locations: Endeavor Health, Evanston, Illinois +3 locations
Conditions: Atrial Fibrillation
Register for Updates
Insertable Cardiac Monitor-Guided Early Intervention to Reduce Atrial Fibrillation Burden Following Catheter Ablation
NCT04922281
Recruiting
To prospectively investigate the efficacy of an insertable cardiac monitor-guided atrial fibrillation (AF) management in reducing subsequent AF burden in patients with persistent or paroxysmal AF undergoing atrial catheter ablation (CA).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/30/2025
Locations: University of Rochester Medical Center, Rochester, New York
Conditions: Atrial Fibrillation, Cardiovascular Diseases, Heart Diseases, Arrhythmias, Cardiac, Pathologic Processes
Register for Updates
Anticoagulation in ICH Survivors for Stroke Prevention and Recovery
NCT03907046
Recruiting
Primary Aim: To determine if apixaban is superior to aspirin for prevention of the composite outcome of any stroke (hemorrhagic or ischemic) or death from any cause in patients with recent ICH and atrial fibrillation (AF). Secondary Aim: To determine if apixaban, compared with aspirin, results in better functional outcomes as measured by the modified Rankin Scale.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/23/2025
Locations: University of Alabama Hospital, Birmingham, Alabama +175 locations
Conditions: Intracerebral Hemorrhage, Atrial Fibrillation
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Anticoagulation for Stroke Prevention In Patients With Recent Episodes of Perioperative AF After Noncardiac Surgery
NCT03968393
Recruiting
Multinational, investigator-initiated study of oral anticoagulation versus no anticoagulation for the prevention of stroke and other adverse cardiovascular events in patients with transient perioperative atrial fibrillation after noncardiac surgery and additional stroke risk factors.
Gender:
ALL
Ages:
55 years and above
Trial Updated:
06/10/2025
Locations: Cedars-Sinai Medical Center, Los Angeles, California +104 locations
Conditions: Stroke, Atrial Fibrillation
Register for Updates
Safety and Efficacy of the Sentinel Cerebral Protection Device in Atrial Fibrillation Ablation
NCT04685317
Recruiting
The purpose of the study is to see if the Sentinel® Cerebral Protection System may prevent occurrence of stroke during an ablation procedure for atrial fibrillation (AF). The secondary purpose of this study is to study if cognitive function after AF ablation differs between those treated with the Sentinel cerebral protection device and those who do not receive the device.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/09/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Arrhythmia, Atrial Fibrillation
Register for Updates