There are currently 144 active clinical trials seeking participants for Autism Spectrum Disorder research studies. The states with the highest number of trials for Autism participants are California, New York, Ohio and Massachusetts.
Peer Interventions for Preschoolers With Autism
Recruiting
This proposal will evaluate a series of peer-mediated interventions (PMIs) for preschool children (3 to 6 years) with ASD and limited or no spoken language, using an innovative Sequential Multiple Assignment Randomized Trial (SMART) design. Available evidence supports the beneficial effects of PMIs for improving social communication in children with ASD. Peer-related social competence is vital to a wide range of child outcomes, such as improved communication and fewer behavioral problems. Unfort... Read More
Gender:
All
Ages:
Between 3 years and 6 years
Trial Updated:
03/26/2024
Locations: Juniper Gardens Children's Project, Kansas City, Kansas +1 locations
Conditions: Autism Spectrum Disorder
taVNS for Anxiety in ASD
Recruiting
Investigators will recruit up to 10 patients with Anxiety comorbid with Autism Spectrum Disorder (ASD) from the outpatient clinics at MUSC. This pilot trial will be an open-label investigation of the safety and feasibility of transcutaneous auricular vagus nerve stimulation (taVNS) as a nonpharmacological wearable intervention used to manage anxiety and other neuropsychiatric symptoms at home, with patients/caretakers self-administering treatments. Each subject will undergo an initial in-person... Read More
Gender:
All
Ages:
Between 12 years and 17 years
Trial Updated:
03/26/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Autism Spectrum Disorder, Anxiety
Early Diagnostic Response Model (EDRM)
Recruiting
Babies Can't Wait (BCW) in Georgia will be referring families with children seeking an autism spectrum disorder (autism) diagnosis at the Emory Autism Center's (EAC) Child Screening and Assessment Clinic.The objective of this study is to develop, pilot, and evaluate a diagnostic protocol for children identified at high risk for autism in the BCW early intervention program screening (part of a public health service). This program evaluation will be using pre- and post-data and data collected thro... Read More
Gender:
All
Ages:
Between 16 months and 36 months
Trial Updated:
03/22/2024
Locations: Emory Autism Center, Atlanta, Georgia
Conditions: Autism Spectrum Disorder, Autism
Patterns of Neurodevelopmental Disorders
Recruiting
The purpose of this study is to systematically evaluate the results of medical investigations to identify symptom and biological patterns and common etiologies of neurodevelopmental disorders.
Gender:
All
Ages:
All
Trial Updated:
03/22/2024
Locations: Rossignol Medical Center, Phoenix, Arizona
Conditions: Neurodevelopmental Disorders, Autism Spectrum Disorder, Pediatric Autoimmune Neuropsychiatric Disorder Associated With Streptococcal Infection, Pediatric Acute-Onset Neuropsychiatric Syndrome, Down Syndrome, Epilepsy, Mitochondrial Encephalomyopathies, Cerebral Folate Deficiency
Role of GABAergic Transmission in Auditory Processing in Autism Spectrum Disorder
Recruiting
Background: Autism spectrum disorder (ASD) is a complex neurodevelopmental syndrome. Researchers think brain development may be controlled by gamma-aminobutyric acid (GABA). They want to learn how abnormalities in the GABA system may contribute to ASD. Objective: To see if repetitive transcranial magnetic stimulation (rTMS) creates short-term changes in how different parts of the brain communicate. Eligibility: Right-handed people ages 14-17 with ASD, and healthy volunteers ages 18-25. Des... Read More
Gender:
All
Ages:
Between 14 years and 25 years
Trial Updated:
03/21/2024
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Autism Spectrum Disorder
Predicting Language and Literacy Growth in Children With ASD Using Statistical Learning
Recruiting
The goal of this observational study is to test a reciprocal relationship between statistical learning and the development of language and literacy in first-graders with autism and their non-autistic peers. The main questions it aims to answer are: whether children's statistical learning abilities can predict their long-term improvement of language and literacy skills in school; how children's brains automatically learn patterns from speech and prints; whether children's learning in the lab ref... Read More
Gender:
All
Ages:
Between 72 months and 90 months
Trial Updated:
03/20/2024
Locations: Northeastern University, Boston, Massachusetts +1 locations
Conditions: Autism Spectrum Disorder, Language Development, Literacy
Adapting BA for Minimally Verbal Autistic Adults
Recruiting
The present study aims to adapt and evaluate the feasibility of the BeatIt-2 behavioral activation intervention for people with intellectual disabilities and low mood to be implemented with minimally verbal autistic individuals.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/20/2024
Locations: Rutgers University - New Brunswick, Piscataway, New Jersey
Conditions: Autism, Depression, Autism Spectrum Disorder With Impaired Functional Language, Autism Spectrum Disorder
Evaluating the Effects of Tasimelteon in Individuals With Autism Spectrum Disorder (ASD) and Sleep Disturbances
Recruiting
This is a multicenter, open-label study to evaluate the efficacy and safety of a daily single oral dose of tasimelteon in treating sleep disturbances in pediatric and adult participants with ASD.
Gender:
All
Ages:
Between 2 years and 65 years
Trial Updated:
03/19/2024
Locations: Vanda Investigational Site, San Jose, California +4 locations
Conditions: Autism Spectrum Disorder, Sleep Disorder, Neurological Disorder, Sleep Disturbance
Melatonin and Sleep Spindles in Autism
Recruiting
Sleep disturbances and sensory sensitivities are common disabling features of autism, but their underlying causes are not clear. We hypothesize that both of these difficulties reflect disrupted communication between a deep brain structure, the thalamus, and the brain's outer layer, the cortex. This communication is mediated by the thalamic reticular nucleus (TRN). Due to its small size and location deep in the brain, we cannot assess TRN function without invasive techniques. Fortunately, sleep s... Read More
Gender:
All
Ages:
Between 12 years and 18 years
Trial Updated:
03/18/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Autism Spectrum Disorder
Natural Treatments for the Management of Emotional Dysregulation in Youth With Non-verbal Learning Disability (NVLD) and/or Autism Spectrum Disorders (ASD)
Recruiting
This study consists of a 6-week, open-label, randomized clinical trial study to compare efficacy and tolerability of the natural treatments omega-3 fatty acids, inositol, and N-acetylcysteine (NAC) in the treatment of mood dysregulation in children and adolescents with non-verbal learning disability (NVLD) or Autism Spectrum Disorder (ASD). Subjects will include youth ages 5-17 years with a non-verbal learning disability (NVLD) or autism spectrum disorder (ASD) and current symptoms of emotional... Read More
Gender:
All
Ages:
Between 5 years and 17 years
Trial Updated:
03/15/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Non-verbal Learning Disorder, Autism Spectrum Disorder, Autism
The Autism Biomarkers Consortium for Clinical Trials: Confirmation Study
Recruiting
This is a multicenter longitudinal study that aims to validate a set of measures that were previously identified as promising candidate biomarkers and/or sensitive and reliable objective measures of social function in ASD for potential use in clinical trials. The confirmation study will repeat the data collection and analysis protocols from the original ABC-CT study. This confirmation study will recruit 200 ASD and 200 TD comparison participants who are 6-11 years old, matching the overall sampl... Read More
Gender:
All
Ages:
Between 6 years and 11 years
Trial Updated:
03/15/2024
Locations: Children's Hospital Los Angeles, Los Angeles, California +4 locations
Conditions: Autism Spectrum Disorder
Targeting Insomnia in School Aged Children With Autism Spectrum Disorder
Recruiting
Children with Autism Spectrum Disorder (ASD) and insomnia, and their parent(s) will undergo 4 sessions of behavioral therapy for sleep problems followed by 4 bimonthly booster sessions. Children and their families will be randomly assigned to one of three conditions: cognitive behavioral therapy (in-person), cognitive behavioral therapy (remote), or behavioral therapy (remote). Arousal will be measured through heart-rate variability. Sleep and secondary outcomes (child daytime behavior, parent s... Read More
Gender:
All
Ages:
Between 6 years and 12 years
Trial Updated:
03/12/2024
Locations: Thompson Center for Autism and Neurodevelopmental Disorders, Columbia, Missouri
Conditions: Insomnia Chronic, Autism Spectrum Disorder