There are currently 146 active clinical trials seeking participants for Chronic Pain research studies. The states with the highest number of trials for Chronic Pain participants are California, Florida, Texas and New York.
Neuroimaging of Opioid Phase (OPAL)
Recruiting
The purpose of this study is to compare activity in the brains of female adults with chronic pain and/or opioid use, and healthy female adults that may help to develop new and targeted treatments for adults with chronic pain and alternatives to opioid therapy.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/11/2025
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Chronic Pain, Opioid Use
Mind Body Intervention for Chronic Upper Extremity Pain (Repetitive Stress Injury)
Recruiting
The goal of this nonrandomized pilot study is to test a mind-body interventional approach for the treatment of chronic upper extremity pain or repetitive stress injury of the upper extremity (wrist/shoulder/elbow). 1. To determine if a mind-body intervention improves upper extremity functional capacity (ie., Disability of Arm Shoulder Hand - DASH) among people with chronic wrist, elbow, and shoulder pain 2. To determine if a mind-body intervention decreases pain intensity, pain-related anxiety,... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
03/26/2025
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Chronic Pain, Chronic Pain Syndrome, Repetitive Stress Injury
Physical Therapy Integrated With Mindfulness for Patients With Chronic Pain and Opioid Treatment
Recruiting
This study will use multiple methods to assess the feasibility of conducting a fully powered multisite clinical trial to test the effectiveness of integrating mindfulness-based interventions into physical therapy for patients with chronic musculoskeletal pain and long-term opioid treatment. First, researchers will develop a manual for training physical therapists to provide mindfulness-based interventions to patients with chronic musculoskeletal pain and long-term opioid treatment. Next, the re... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
03/21/2025
Locations: University of Florida, Gainesville, Florida +1 locations
Conditions: Chronic Pain, Pain, Musculoskeletal, Opioid Use, Physical Therapy
Mind Body Intervention for Chronic Migraine Headaches
Recruiting
The goal of this exploratory study is to test a mind-body interventional approach for the treatment of chronic migraines. The main goal is to obtain feasibility information on the protocol which has been used in other similar conditions. We will also evaluate multiple measurement tools in order to optimize a follow-up pilot study evaluating the impact of the protocol on migraines.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/19/2025
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts +1 locations
Conditions: Migraines, Chronic Pain
Generate and Test the Reliability of a PD Model of OXT on Pupillary Hippus as a Measure of CNS Activity
Recruiting
The purpose of this research is to evaluate the effects of oxytocin (naturally occurring hormone) given by an intramuscular (IM; into the muscle) injection, has on your parasympathetic nervous system. The parasympathetic nervous system is the part of the involuntary nervous system that is sometimes called the "rest and digest" system; the parasympathetic system conserves energy as it slightly slows the heart rate, increases intestinal and gland activity, and relaxes sphincter muscles in the gast... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
03/19/2025
Locations: Wake Forest Baptist Health, Winston-Salem, North Carolina
Conditions: Chronic Pain, Osteoarthritis, Knee
PAIN: a Project Assessing the Impact of a Novel Cannabinoid Product
Recruiting
This study is a clinical trial of a high-cannabidiol (CBD) sublingual product compared to placebo for 9 weeks in patients with chronic pain conditions. The study will assess the impact of CBD on chronic pain symptoms, conventional medication use, clinical state, quality of life, cognition, and biomarkers.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
03/14/2025
Locations: McLean Hospital, Belmont, Massachusetts
Conditions: Chronic Pain
VR Mindfulness Training for Veterans With SCI
Recruiting
This study involves delivering a mindfulness program that was developed for Veterans called VA Compassionate Awareness Learning Module (VA CALM) to Veterans with spinal cord injuries (SCI) to develop accommodations to make the VA CALM program more accessible for those with SCI. It will involve delivering the unmodified curriculum to a group of Veterans with SCI first to determine what areas need accommodations, working with a group of stakeholders to develop appropriate accommodations, and then... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/14/2025
Locations: Michael E. DeBakey VA Medical Center, Houston, TX, Houston, Texas
Conditions: Spinal Cord Injury, Chronic Pain
Our Whole Lives Gemini: Virtual Integrative Medical Group Visits for Managing Chronic Pain
Recruiting
The goal of this research study is to test the efficacy of a non-prescription medicine, web-based platform solution for patients with chronic pain, to improve pain self-management and related outcomes. The main question investigators aim to answer is; would the use of this web-based intervention plus an online group visit compared to control result in better pain-related outcomes and improved pain impact?
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/12/2025
Locations: Cambridge Health Alliance Center for Mindfulness and Compassion, Malden, Massachusetts
Conditions: Chronic Pain
Stanford Pragmatic Effectiveness Comparison
Recruiting
Chronic pain is a major healthcare problem with an annual cost of above $600 billion. The quality of data available for treatments of chronic pain is not optimal. Generalizability of explanatory randomized controlled trial data is problematic as these trials exclude up to 90% of patients: leaving out real-world patients with serious medical and psychological comorbidities. Pragmatic trials embedded in patient care compare effectiveness of currently used treatments in real-world application leadi... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/03/2025
Locations: Stanford Pain Management Center, Redwood City, California
Conditions: Chronic Pain
Pain Self-Management and Treatment Engagement for Patients Taking Opioids
Recruiting
The goal of this study is to learn if Pain Self-Management (PSM) can improve chronic pain care in individuals with opioid misuse or opioid use disorder (OUD) The main questions it aims to answer are: * Does PSM help participants manage their chronic pain more effectively? * Does PSM help participants engage in treatment for opioid use? Researchers will compare PSM to standard care to see if PSM is effective in managing chronic pain and engagement in treatment. Participants will: * Take part... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/03/2025
Locations: Community Medicine, Inc., Pittsburgh, Pennsylvania +8 locations
Conditions: Chronic Pain, Opioid Use Disorder, Opioid Misuse and Addiction
Partners4Pain & Wellbeing Equity: A Randomized Trial of Community Supported Complementary and Integrative Health Self-management for Back Pain
Recruiting
The goal of this clinical trial is to learn how well two community-based self-management programs work in people with chronic back or neck pain from populations that have been minoritized based on race, ethnicity, or income. The main question it aims to answer is: How well does a community-based self-management program teaching mind-body skills such as mindfulness and cognitive behavioral approaches (Partners4Pain) work for reducing pain intensity and interference with general activities and en... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/13/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Chronic Pain, Back Pain, Neck Pain, Self-management, Complementary Therapies, Health Inequity
Dronabinol as an Adjunct for Reducing Pain
Recruiting
This exploratory, proof-of-concept study is a double-blind (participants and investigators will be blinded), placebo-controlled, randomized, two-arm clinical trial of Marinol \[dronabinol, synthetic Δ9-tetrahydrocannabinol (THC)\] for chronic low back pain (cLBP) with a 2:1 allocation ratio. Up to 75 subjects will be enrolled in this pilot study and randomized to receive doses of THC (up to 30 mg/day), orally, over 8 weeks. This study will be conducted at a single site; it does not include any s... Read More
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
02/13/2025
Locations: Michael E Debakey VA Medical Center, Houston, Texas
Conditions: Low Back Pain, Chronic Pain, Back Injuries