Chronic Pain Clinical Trials

A listing of 146 Chronic Pain clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.

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There are currently 146 active clinical trials seeking participants for Chronic Pain research studies. The states with the highest number of trials for Chronic Pain participants are California, Florida, Texas and New York.

Featured Trial

Healthy Participants Needed (Colonoscopy + Cancer Screening)

Recruiting

Earn $325 - $475 in electronic payment card compensation for your time and effort by participating in a clinical study to develop a blood test that may one day help screen for colon cancer. Take a quick quiz to see if you qualify.

Conditions:

Healthy

Healthy Volunteers

Healthy Subjects

Healthy Volunteer

Healthy Participants

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Featured Trial

Paid Clinical Studies Nationwide

Recruiting

Nationwide clinical trials offered in your area. Some trials offering up to several thousand dollars in compensation for participation.

Conditions:

Healthy

Healthy Volunteer Study

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Featured Trial

Buy Retatrutide Online Through Celia

Recruiting

Retatrutide (formerly M25) is an investigational peptide being studied for its potential in supporting weight management and metabolic health. It acts on GLP-1, GIP, and glucagon receptors to influence appetite, energy regulation, and fat metabolism.

Conditions:

Healthy

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Featured Trial

Vaccine (18+) Clinical Study

Recruiting

We are seeking healthy individuals aged 18 and above who are interested in participating in a vaccine clinical trial.

Conditions:

Vaccine (18+)

Healthy

Healthy Individuals

Healthy Volunteers

Healthy Subjects

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Decision Making in Chronic Pain and Alcohol Use Disorder

NCT05901610

Recruiting

The objective of this within-subject study is to test the effects of Episodic Future Thinking (EFT) and Low-intensity Focused Ultrasound (LIFU) interventions on the pain of subjects who have chronic pain and alcohol use disorder(s).

Gender:

ALL

Ages:

21 years and above

Trial Updated:

02/10/2025

Locations: Fralin Biomedical Research Institute at VTC, Roanoke, Virginia

Conditions: Alcohol Use Disorder, Chronic Pain

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Low-Intensity Focused Ultrasound and the Complex Patient

NCT06297200

Recruiting

Studying the effects of Low Intensity Focused Ultrasound (LIFU) on measures of pain, craving, and anxiety in a complex patient population.

Gender:

ALL

Ages:

Between 18 years and 65 years

Trial Updated:

01/09/2025

Locations: Fralin Biomedical Research Institute at VTC, Roanoke, Virginia

Conditions: Opioid Use Disorder, Chronic Pain, Anxiety Disorder

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Insula Neuromodulation for Chronic Neuropathic Pain

NCT05404581

Recruiting

This study will comprehensively investigate the insula as a brain target for neuromodulation to treat chronic neuropathic pain.

Gender:

ALL

Ages:

Between 18 years and 80 years

Trial Updated:

12/04/2024

Locations: University of Virginia, Charlottesville, Virginia

Conditions: Neuropathic Pain, Chronic Pain

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Low-Intensity Focused Ultrasound For Insular Neuromodulation in Chronic Pain

NCT05751096

Recruiting

Study investigating the potential benefit for chronic pain patients (CRPS and FM) using low-intensity focused ultrasound for neuromodulation.

Gender:

ALL

Ages:

Between 18 years and 65 years

Trial Updated:

10/12/2023

Locations: Fralin Biomedical Research Institute, Roanoke, Virginia

Conditions: Fibromyalgia, Complex Regional Pain Syndromes, Chronic Pain

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Clinical Utility of Neurophysiological Measurements of ECAP-controlled Closed-loop SCS to Guide Treatment of Chronic Pain

NCT06229470

Recruiting

The purpose of this study is to evaluate the clinical utility of neurophysiological measurements of ECAP-controlled closed-loop SCS (i.e., neural panel metrics) to guide treatment of chronic pain of the trunk and/or limbs.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

08/19/2025

Locations: Lakeside Spine and Pain, Lake Havasu City, Arizona +24 locations

Lakeside Spine and Pain, Lake Havasu City, Arizona

Spanish Hills Interventional Pain Specialists, Camarillo, California

Pain Consultants of San Diego, La Mesa, California

Pacific Research Institute, Santa Rosa, California

Boomerang Healthcare, Walnut Creek, California

DBPS Research, Greenwood Village, Colorado

Pohlman Pain Associates, Delray Beach, Florida

Horizon Clinical Research, Jasper, Georgia

Rockford Pain Center, Rockford, Illinois

Goodman Campbell Brain and Spine, Carmel, Indiana

Metro Anesthesia & Pain Management, Des Moines, Iowa

Restorative Pain Institute, Louisville, Kentucky

Advanced Pain Institute, Hammond, Louisiana

Spine and Joint Institute, Glen Burnie, Maryland

Michigan Pain Specialists, Ann Arbor, Michigan

Pain Clinic of Michigan, Rochester Hills, Michigan

Tricity Research Center, LLC, Grand Island, Nebraska

Reno Tahoe Pain Associates, Reno, Nevada

Garden State Pain and Orthopedics, Clifton, New Jersey

Seaside Clinical Research Institute, Wilmington, North Carolina

Cleveland Clinic Foundation, Cleveland, Ohio

Premier Pain Treatment Institute, Loveland, Ohio

Carolinas Center for Advanced Management of Pain, Greenville, South Carolina

Institute of Precision Pain Medicine, Corpus Christi, Texas

Victoria Pain and Rehabilitation Center, Victoria, Texas

Conditions: Chronic Pain

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Brief Intervention for Chronic Pain and History of Stressful Experiences

NCT06983327

Recruiting

The goal of this study is to understand whether a brief, three session program can be helpful in reducing symptoms related to both chronic pain and stressful experiences/trauma.

Gender:

ALL

Ages:

21 years and above

Trial Updated:

08/18/2025

Locations: Brigham and Women's Hospital, Chestnut Hill, Massachusetts

Conditions: Chronic Pain, Trauma, Adverse Childhood Experiences

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TMS-EEG Biomarkers for Chronic Pain

NCT07116278

Recruiting

In this study the investigators aim to assess the correlates of neurophysiological measures (measurement of brain magnetically evoked response) using DELPHI system. The DELPHI system device is a computerized, electromechanical medical device that produces and delivers non-invasive Transcranial Magnetic Stimulation (TMS) fields to induce electrical currents directed at regions of the cerebral cortex and records the resultant Electroencephalogram (EEG) brain electrophysiological response. DELPHI a... Read More

Gender:

ALL

Ages:

Between 18 years and 80 years

Trial Updated:

08/15/2025

Locations: UCSF, San Francisco, California

Conditions: Chronic Pain

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Effect of Music on Pain and Anxiety in Chronic Pain Patients Undergoing Lumbar Interventional Procedures.

NCT04924244

Recruiting

The purpose of this study is to evaluate, subjectively and objectively, whether playing music during procedures for treatment of chronic lower back pain has an effect on patients' anxiety and pain. The investigators hypothesize that playing music will result in reduced patient reported anxiety and pain scores and less variation from baseline of vital signs versus patients in the control group without music therapy. This is a pilot study.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

08/14/2025

Locations: Milton S. Hershey Medical Center, Hershey, Pennsylvania

Conditions: Chronic Pain, Anxiety

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Under-Resourced Adults With Chronic Pain eHealth Study

NCT06688864

Recruiting

The purpose of this study is to examine the feasibility of the dissemination of a cognitive-behavioral eHealth application (app) for pain self-management with Black and LGBTQ+ adults with high-impact chronic pain lasting at least 3 months and disrupting daily functioning (Implementation aim).

Gender:

ALL

Ages:

18 years and above

Trial Updated:

08/12/2025

Locations: Mayo Clinic in Rochester, Rochester, Minnesota

Conditions: Chronic Pain

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Patient Retrospective Outcomes (PRO)

NCT01550575

Recruiting

This study will evaluate de-identified (anonymous) data in subject medical charts to review the clinical outcomes of various treatment approaches in the treatment of chronic pain.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

08/11/2025

Locations: Lakeside Spine & Pain, Lake Havasu City, Arizona +141 locations

Lakeside Spine & Pain, Lake Havasu City, Arizona

Hope Research Institute, Phoenix, Arizona

Kern Neuroscience Institute, Bakersfield, California

Pain Consultants of San Diego, Chula Vista, California

Pain Medicine Associates, Inc., Fountain Valley, California

UCSD Medical Center - Jacobs Medical Center, La Jolla, California

California Orthopedics & Spine, Larkspur, California

MarinHealth Spine Institute, Larkspur, California

Loma Linda University Medical Center, Loma Linda, California

Newport Beach Headache and Pain, Newport Beach, California

Vitamed Research, Rancho Mirage, California

Pacific Pain Management, Inc., Ventura, California

IPM Medical Group Inc., Walnut Creek, California

Barolat Neuroscience, Denver, Colorado

Advanced Diagnostic Pain Treatment Centers, New Haven, Connecticut

South Lake Pain Institute, Inc, Clermont, Florida

Florida Spine Specialists, Fort Lauderdale, Florida

Louis J. Raso, MD, PA, Jupiter, Florida

Florida Pain Institute, Merritt Island, Florida

Advanced Interventional Pain Management and Research Clinic, Inc., Miami Gardens, Florida

Florida Pain Clinic, Ocala, Florida

Orthomicrospine, Pensacola, Florida

HCA Florida West Orthopedic Specialists, Pensacola, Florida

West Florida Orthopedics and Spine Surgery, Pensacola, Florida

Interventional Spine and Pain Institute, Vero Beach, Florida

Orthopedic Research Foundation, Savannah, Georgia

Centurion Spine and Pain, Waycross, Georgia

Tripler Army Medical Center, Honolulu, Hawaii

Pain and Spine Specialists of Idaho, Idaho Falls, Idaho

North Idaho Day Surgery, Post Falls, Idaho

Northwestern Memorial Hospital, Chicago, Illinois

Summit Research Institute, Fort Wayne, Indiana

Comprehensive Pain and Spine Specialists, Muncie, Indiana

Henry Community Health, New Castle, Indiana

Precision Spine Care, Overland Park, Kansas

Willis-Knighton River Cities Clinical Research Center, Shreveport, Louisiana

Pain and Spine Specialist of Maryland, Mount Airy, Maryland

Michigan Orthopedic Center, Lansing, Michigan

Multidisciplinary Pain Management Services, Okemos, Michigan

Forest Health Medical Center, Ypsilanti, Michigan

Twin Cities Pain Clinic & Surgery Center, Edina, Minnesota

NeuroSpecs-Gulfport Performance Spine, Gulfport, Mississippi

Comprehensive Pain & Rehabilitation, Pascagoula, Mississippi

Saint Louis Pain Consultants, Chesterfield, Missouri

Mercy Medical Research Institute, Springfield, Missouri

Albany Medical Center, Albany, New York

Jeffrey M. Epstein, M.D. PC, Babylon, New York

Montefiore Medical Center, Bronx, New York

Spine and Skeletal Pain Medicine, Utica, New York

Integrative Pain and Wellness Associates, Williamsville, New York

Vidant Roanoke - Chowan Hospital Pain Center, Ahoskie, North Carolina

Carolinas Research Institute, PLLC, Huntersville, North Carolina

Crystal Coast Pain Management, New Bern, North Carolina

Piedmont Interventional Pain Care, Salisbury, North Carolina

The Center for Clinical Research, LLC, Winston-Salem, North Carolina

Interventional Pain and Spine, Cincinnati, Ohio

University Hospitals of Cleveland, Cleveland, Ohio

Orthopaedic and Spine Center, Dublin, Ohio

Cincinnati Comprehensive Pain Center, Fairfield, Ohio

Western Reserve Spine and Pain Institute, Kent, Ohio

Interventional Pain Consultants, Toledo, Ohio

Toledo Clinic, Toledo, Ohio

University of Toledo Medical Center, Toledo, Ohio

Pacific Sports and Spine, LLC, Eugene, Oregon

Pain Specialists of Southern Oregon, Medford, Oregon

Quave Clinic, Medford, Oregon

Southern Oregon Orthopedics, Medford, Oregon

Summit Spine, Portland, Oregon

Geisinger Medical Center, Danville, Pennsylvania

Florence Neurosurgery and Spine, Florence, South Carolina

PCPMG Clinical Research Unit, LLC, Greenville, South Carolina

Interventional Spine and Pain Center, Manchester, Tennessee

Comprehensive Pain & Neurology Center, Murfreesboro, Tennessee

Pain Center Physicians, Austin, Texas

Balcones Pain Consultants, Austin, Texas

KSF Orthopaedics, Houston, Texas

Central Texas Pain Institute, Killeen, Texas

Advanced Spine Pain Solutions, Laredo, Texas

Spine Team Texas, Southlake, Texas

Space City Pain Specialists, Webster, Texas

University of Utah Orthopaedic Center, Salt Lake City, Utah

Carilion Roanoke Memorial Hospital, Roanoke, Virginia

EvergreenHealth Pain Care, Kirkland, Washington

Mind Your Body Institute, Seattle, Washington

Northwest Pain Care, Spokane, Washington

West Virginia University Hospitals, Morgantown, West Virginia

Interventional Pain Specialists of Wisconsin, Rice Lake, Wisconsin

Berwick Pain Management, Berwick, Not set

Hunter Pain Clinic, Broadmeadow, Not set

Monash Clinical Research, Caulfield South, Not set

Green Lizard Science, Claremont, Not set

Sydney Spine and Pain Pty Ltd, Hurstville, Not set

Sunshine Coast Clinical Research, Noosa Heads, Not set

Womens Health and Research Institute of Australia, Sydney, Not set

Pain Medicine of South Australia, Wayville, Not set

Clinique Saint-Pierre Ottignies, Ottignies, Not set

Clinique de la Sauvegarde, Lyon, Not set

Hopital Prive du Confluent SAS, Nantes, Not set

Fondation Ophtalmologique Adolphe de Rothschild, Paris, Not set

CHU La Miletrie, Poitiers, Not set

CHU de Nantes-Hopital Laennec, Saint-Herblain, Not set

Hopital Foch, Suresnes, Not set

University Berlin, Charite Virchow Standort, Wedding, Berlin-Wedding, Not set

Inter Neuro, Berlin, Not set

Uniklinik Köln, Cologne, Not set

Universitaetsklinikum Dusseldorf, Duesseldorf, Not set

St. Marien-Hospital Hamm, Hamm, Not set

Pres. Osp. Civile Santi Antonio e Biagio, Alessandria, Not set

Az. Osp. Monaldi, Napoli, Not set

AUSL della Romagna, Ravenna, Not set

Ospedale San Giuliano, Rionero In Vulture, Not set

Ospedale S. Giovanni Addolorata, Rome, Not set

Policlinico Universitario Agostino Gemelli, Rome, Not set

Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Not set

Alrijne Ziekenhuis Leiderdorp, Leiderdorp, Not set

Ziekenhuis Rijnstate, Velp, Not set

CHU Sao Joao, Porto, Not set

Ponce Interventional Pain Center, Ponce, Not set

Hospital De Bellvitge, Barcelona, Not set

H. Puerta Del Mar, Cadiz, Not set

Complejo Hospitalario Universitario de Cartagena, Cartagena, Not set

Hospital Universitario Doctor Jose Molina Orosa, Las Palmas, Not set

Hospital San Pedro, Logroño, Not set

Fundacion Jimenez Diaz, Madrid, Not set

Hospital Clinico San Carlos, Madrid, Not set

Hospital La Paz, Madrid, Not set

Hospital Universitario Quiron Madrid, Madrid, Not set

Hospital Puerta de Hierro, Majadahonda, Not set

Complexo Hospitalario Universitario de Ourense (CHUO), Orense, Not set

Hospital Virgen Del Rocio, Sevilla, Not set

H. Clinico Universitario, Valencia, Not set

Hospital de la Ribera, Valencia, Not set

Hospital Universitario La Fe, Valencia, Not set

Sahlgrenska University Hospital, Goeteborg, Not set

La Tour Hospital, Meyrin, Not set

Ospedale Regionale di Lugano, Viganello, Not set

Basildon and Thurrock University Hospitals NHS, Basildon, Not set

Southmead Hospital Bristol, Bristol, Not set

Royal Devon & Exeter Hospital, Exeter, Not set

The General Infirmary, Leeds, Not set

St. Bartholomews Hospital, London, Not set

James Cook University Hospital, Middlesbrough, Not set

Conditions: Chronic Pain

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A DirEct to PatieNt Study in Chronic Pain

NCT05515341

Recruiting

To compile real-world, direct from patient clinical outcomes and objective metrics in patients who have received or plan to receive a commercially approved interventional medical device therapy/procedure for chronic pain in routine clinical practice.

Gender:

ALL

Ages:

22 years and above

Trial Updated:

08/11/2025

Locations: Boston Scientific Neuromodulation, Valencia, California

Conditions: Chronic Pain

Learn More ›

A Bionic Breast Project Using Neuroprosthesis to Reduce Chronic Pain After Mastectomy

NCT06382272

Recruiting

This trial seeks to establish whether or not touch sensation can be restored to the breast via neural stimulation. Data will also be obtained to inform future feasibility (including safety), efficacy, and acceptability trials.

Gender:

FEMALE

Ages:

18 years and above

Trial Updated:

08/07/2025

Locations: University of Chicago Medicine Comprehensive Cancer Center, Chicago, Illinois

Conditions: Mastectomy, Breast, Chronic Pain

Learn More ›