Chronic Pain Clinical Trials & Research Studies Near You (Updated 7/25)

Clinical Utility of Neurophysiological Measurements of ECAP-controlled Closed-loop SCS to Guide Treatment of Chronic Pain

NCT06229470

Recruiting

The purpose of this study is to evaluate the clinical utility of neurophysiological measurements of ECAP-controlled closed-loop SCS (i.e., neural panel metrics) to guide treatment of chronic pain of the trunk and/or limbs.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/11/2025

Locations: Lakeside Spine and Pain, Lake Havasu City, Arizona +24 locations

Lakeside Spine and Pain, Lake Havasu City, Arizona

Spanish Hills Interventional Pain Specialists, Camarillo, California

Pain Consultants of San Diego, La Mesa, California

Pacific Research Institute, Santa Rosa, California

Boomerang Healthcare, Walnut Creek, California

DBPS Research, Greenwood Village, Colorado

Pohlman Pain Associates, Delray Beach, Florida

Horizon Clinical Research, Jasper, Georgia

Rockford Pain Center, Rockford, Illinois

Goodman Campbell Brain and Spine, Carmel, Indiana

Metro Anesthesia & Pain Management, Des Moines, Iowa

Restorative Pain Institute, Louisville, Kentucky

Advanced Pain Institute, Hammond, Louisiana

Spine and Joint Institute, Glen Burnie, Maryland

Michigan Pain Specialists, Ann Arbor, Michigan

Pain Clinic of Michigan, Rochester Hills, Michigan

Tricity Research Center, LLC, Grand Island, Nebraska

Reno Tahoe Pain Associates, Reno, Nevada

Garden State Pain and Orthopedics, Clifton, New Jersey

Seaside Clinical Research Institute, Wilmington, North Carolina

Cleveland Clinic Foundation, Cleveland, Ohio

Premier Pain Treatment Institute, Loveland, Ohio

Carolinas Center for Advanced Management of Pain, Greenville, South Carolina

Institute of Precision Pain Medicine, Corpus Christi, Texas

Victoria Pain and Rehabilitation Center, Victoria, Texas

Conditions: Chronic Pain

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Impact of 4PCP on Practitioner and Patient Outcomes

NCT05580419

Recruiting

Reducing opioid prescribing and improving outcomes in patients with chronic pain would benefit our nation. Neither addiction nor chronic pain spares any race, gender, or particular socio-economic status. This study is investigating a potentially inexpensive way of providing a previously costly service (the intensive chronic pain rehabilitation program), which is why insurers stopped covering it. Although it is unusual for an application from an academic institution to include a startup company (... Read More

Gender:

ALL

Ages:

Between 14 years and 80 years

Trial Updated:

07/11/2025

Locations: Case Western Reserve University, Cleveland, Ohio +3 locations

Conditions: Chronic Pain

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Emotional Awareness and Expression Therapy for People With Persistent Pain Following Orthopedic Trauma

NCT05989230

Recruiting

The purpose of this single-arm trial is to determine the feasibility of emotional awareness and expression therapy (EAET) for individuals with persistent pain following orthopedic trauma. As part of this study, participants will be asked to attend weekly EAET treatment sessions and complete assessments (including pre-treatment, post-treatment, and follow-up) consisting of questionnaires and sensory testing procedures.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/10/2025

Locations: Johns Hopkins School of Medicine, Baltimore, Maryland

Conditions: Orthopaedic Trauma, Chronic Pain, Musculoskeletal Injury

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Examining Racial and Socioeconomic Differences in Chronic Low Back Pain

NCT05991440

Recruiting

The purpose of this research study is to gain a better understanding of how people's racial background and socioeconomic status (e.g., income, education, and employment) impact their experiences of chronic low back pain (cLBP).

Gender:

ALL

Ages:

Between 18 years and 85 years

Trial Updated:

07/09/2025

Locations: Washington University School of Medicine, St. Louis, Missouri

Conditions: Chronic Pain

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Developing a Tailored Psychosocial Education Intervention for Chronic Pain Management for Asian Americans

NCT06725329

Recruiting

Health inequalities in chronic pain exists in the US, with a greater burden of chronic pain and higher rate of misdiagnosis and undertreatment reported in minoritized groups compared to non-Hispanic Whites. Asian Americans (AA) are the fastest-growing racial/ethnic group in the US, yet despite the rapid growth in their numbers, AA remain under-represented in pain disparity research. Cultural norms of Asians may discourage reporting their pain to avoid burdening others or being seen as weak. Rath... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/09/2025

Locations: The George washington University, Washington, District of Columbia +1 locations

Conditions: Chronic Pain

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Patient Retrospective Outcomes (PRO)

NCT01550575

Recruiting

This study will evaluate de-identified (anonymous) data in subject medical charts to review the clinical outcomes of various treatment approaches in the treatment of chronic pain.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/08/2025

Locations: Lakeside Spine & Pain, Lake Havasu City, Arizona +140 locations

Lakeside Spine & Pain, Lake Havasu City, Arizona

Hope Research Institute, Phoenix, Arizona

Kern Neuroscience Institute, Bakersfield, California

Pain Consultants of San Diego, Chula Vista, California

Pain Medicine Associates, Inc., Fountain Valley, California

UCSD Medical Center - Jacobs Medical Center, La Jolla, California

California Orthopedics & Spine, Larkspur, California

MarinHealth Spine Institute, Larkspur, California

Loma Linda University Medical Center, Loma Linda, California

Newport Beach Headache and Pain, Newport Beach, California

Vitamed Research, Rancho Mirage, California

Pacific Pain Management, Inc., Ventura, California

IPM Medical Group Inc., Walnut Creek, California

Barolat Neuroscience, Denver, Colorado

Advanced Diagnostic Pain Treatment Centers, New Haven, Connecticut

South Lake Pain Institute, Inc, Clermont, Florida

Florida Spine Specialists, Fort Lauderdale, Florida

Louis J. Raso, MD, PA, Jupiter, Florida

Florida Pain Institute, Merritt Island, Florida

Advanced Interventional Pain Management and Research Clinic, Inc., Miami Gardens, Florida

Florida Pain Clinic, Ocala, Florida

Orthomicrospine, Pensacola, Florida

HCA Florida West Orthopedic Specialists, Pensacola, Florida

West Florida Orthopedics and Spine Surgery, Pensacola, Florida

Interventional Spine and Pain Institute, Vero Beach, Florida

Orthopedic Research Foundation, Savannah, Georgia

Centurion Spine and Pain, Waycross, Georgia

Tripler Army Medical Center, Honolulu, Hawaii

Pain and Spine Specialists of Idaho, Idaho Falls, Idaho

North Idaho Day Surgery, Post Falls, Idaho

Northwestern Memorial Hospital, Chicago, Illinois

Summit Research Institute, Fort Wayne, Indiana

Henry Community Health, New Castle, Indiana

Precision Spine Care, Overland Park, Kansas

Willis-Knighton River Cities Clinical Research Center, Shreveport, Louisiana

Pain and Spine Specialist of Maryland, Mount Airy, Maryland

Michigan Orthopedic Center, Lansing, Michigan

Multidisciplinary Pain Management Services, Okemos, Michigan

Forest Health Medical Center, Ypsilanti, Michigan

Twin Cities Pain Clinic & Surgery Center, Edina, Minnesota

NeuroSpecs-Gulfport Performance Spine, Gulfport, Mississippi

Comprehensive Pain & Rehabilitation, Pascagoula, Mississippi

Saint Louis Pain Consultants, Chesterfield, Missouri

Mercy Medical Research Institute, Springfield, Missouri

Albany Medical Center, Albany, New York

Jeffrey M. Epstein, M.D. PC, Babylon, New York

Montefiore Medical Center, Bronx, New York

Spine and Skeletal Pain Medicine, Utica, New York

Integrative Pain and Wellness Associates, Williamsville, New York

Vidant Roanoke - Chowan Hospital Pain Center, Ahoskie, North Carolina

Carolinas Research Institute, PLLC, Huntersville, North Carolina

Crystal Coast Pain Management, New Bern, North Carolina

Piedmont Interventional Pain Care, Salisbury, North Carolina

The Center for Clinical Research, LLC, Winston-Salem, North Carolina

Interventional Pain and Spine, Cincinnati, Ohio

University Hospitals of Cleveland, Cleveland, Ohio

Orthopaedic and Spine Center, Dublin, Ohio

Cincinnati Comprehensive Pain Center, Fairfield, Ohio

Western Reserve Spine and Pain Institute, Kent, Ohio

Interventional Pain Consultants, Toledo, Ohio

Toledo Clinic, Toledo, Ohio

University of Toledo Medical Center, Toledo, Ohio

Pacific Sports and Spine, LLC, Eugene, Oregon

Pain Specialists of Southern Oregon, Medford, Oregon

Quave Clinic, Medford, Oregon

Southern Oregon Orthopedics, Medford, Oregon

Summit Spine, Portland, Oregon

Geisinger Medical Center, Danville, Pennsylvania

Florence Neurosurgery and Spine, Florence, South Carolina

PCPMG Clinical Research Unit, LLC, Greenville, South Carolina

Interventional Spine and Pain Center, Manchester, Tennessee

Comprehensive Pain & Neurology Center, Murfreesboro, Tennessee

Pain Center Physicians, Austin, Texas

Balcones Pain Consultants, Austin, Texas

KSF Orthopaedics, Houston, Texas

Central Texas Pain Institute, Killeen, Texas

Advanced Spine Pain Solutions, Laredo, Texas

Spine Team Texas, Southlake, Texas

Space City Pain Specialists, Webster, Texas

University of Utah Orthopaedic Center, Salt Lake City, Utah

Carilion Roanoke Memorial Hospital, Roanoke, Virginia

EvergreenHealth Pain Care, Kirkland, Washington

Mind Your Body Institute, Seattle, Washington

Northwest Pain Care, Spokane, Washington

West Virginia University Hospitals, Morgantown, West Virginia

Interventional Pain Specialists of Wisconsin, Rice Lake, Wisconsin

Berwick Pain Management, Berwick, Not set

Hunter Pain Clinic, Broadmeadow, Not set

Monash Clinical Research, Caulfield South, Not set

Green Lizard Science, Claremont, Not set

Sydney Spine and Pain Pty Ltd, Hurstville, Not set

Sunshine Coast Clinical Research, Noosa Heads, Not set

Womens Health and Research Institute of Australia, Sydney, Not set

Pain Medicine of South Australia, Wayville, Not set

Clinique Saint-Pierre Ottignies, Ottignies, Not set

Clinique de la Sauvegarde, Lyon, Not set

Hopital Prive du Confluent SAS, Nantes, Not set

Fondation Ophtalmologique Adolphe de Rothschild, Paris, Not set

CHU La Miletrie, Poitiers, Not set

CHU de Nantes-Hopital Laennec, Saint-Herblain, Not set

Hopital Foch, Suresnes, Not set

University Berlin, Charite Virchow Standort, Wedding, Berlin-Wedding, Not set

Inter Neuro, Berlin, Not set

Uniklinik Köln, Cologne, Not set

Universitaetsklinikum Dusseldorf, Duesseldorf, Not set

St. Marien-Hospital Hamm, Hamm, Not set

Pres. Osp. Civile Santi Antonio e Biagio, Alessandria, Not set

Az. Osp. Monaldi, Napoli, Not set

AUSL della Romagna, Ravenna, Not set

Ospedale San Giuliano, Rionero In Vulture, Not set

Ospedale S. Giovanni Addolorata, Rome, Not set

Policlinico Universitario Agostino Gemelli, Rome, Not set

Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Not set

Alrijne Ziekenhuis Leiderdorp, Leiderdorp, Not set

Ziekenhuis Rijnstate, Velp, Not set

CHU Sao Joao, Porto, Not set

Ponce Interventional Pain Center, Ponce, Not set

Hospital De Bellvitge, Barcelona, Not set

H. Puerta Del Mar, Cadiz, Not set

Complejo Hospitalario Universitario de Cartagena, Cartagena, Not set

Hospital Universitario Doctor Jose Molina Orosa, Las Palmas, Not set

Hospital San Pedro, Logroño, Not set

Fundacion Jimenez Diaz, Madrid, Not set

Hospital Clinico San Carlos, Madrid, Not set

Hospital La Paz, Madrid, Not set

Hospital Universitario Quiron Madrid, Madrid, Not set

Hospital Puerta de Hierro, Majadahonda, Not set

Complexo Hospitalario Universitario de Ourense (CHUO), Orense, Not set

Hospital Virgen Del Rocio, Sevilla, Not set

H. Clinico Universitario, Valencia, Not set

Hospital de la Ribera, Valencia, Not set

Hospital Universitario La Fe, Valencia, Not set

Sahlgrenska University Hospital, Goeteborg, Not set

La Tour Hospital, Meyrin, Not set

Ospedale Regionale di Lugano, Viganello, Not set

Basildon and Thurrock University Hospitals NHS, Basildon, Not set

Southmead Hospital Bristol, Bristol, Not set

Royal Devon & Exeter Hospital, Exeter, Not set

The General Infirmary, Leeds, Not set

St. Bartholomews Hospital, London, Not set

James Cook University Hospital, Middlesbrough, Not set

Conditions: Chronic Pain

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A DirEct to PatieNt Study in Chronic Pain

NCT05515341

Recruiting

To compile real-world, direct from patient clinical outcomes and objective metrics in patients who have received or plan to receive a commercially approved interventional medical device therapy/procedure for chronic pain in routine clinical practice.

Gender:

ALL

Ages:

22 years and above

Trial Updated:

07/07/2025

Locations: Boston Scientific Neuromodulation, Valencia, California

Conditions: Chronic Pain

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Pain Self-Management and Patient-Oriented Dosing for Pain and in Retention Opioid Treatment

NCT06367387

Recruiting

This study seeks to improve the treatment of chronic pain in people who are taking buprenorphine (also known as Suboxone, Subutex, Zubsolv). The research study is testing two different interventions along with usual clinical care: 1. Pain Self-Management (PSM): an educational program in which individuals with chronic pain work with a trained pain coach and a pain peer to explore strategies to effectively manage the daily problems that arise from chronic pain. 2. Patient-Oriented Dosing (POD):... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/03/2025

Locations: Alcohol and Drug Abuse Program (ADAP) - UM Addiction Treatment Center, Baltimore, Maryland +12 locations

Conditions: Opioid Use Disorder, Chronic Pain

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Virtual Reality Treatment for Adults With Chronic Back Pain (VRNT)

NCT07033195

Recruiting

Participants with chronic back pain will complete an online Qualtrics eligibility survey. After signing a consent form, eligible participants enter a two-week baseline period ("Baseline Period") during which they complete two assessments of the Primary and Secondary Outcome Measures and Potential Mediators. After the baseline period, participants are randomized into a treatment group ("Therapy Group") or a control intervention group ("Control Group") with a ratio of 1:1 (treatment:control). Both... Read More

Gender:

ALL

Ages:

Between 18 years and 85 years

Trial Updated:

07/03/2025

Locations: University of Colorado Boulder, Boulder, Colorado

Conditions: Chronic Pain, Chronic Back Pain, Chronic Lower Back Pain (CLBP)

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Group Integrative Breathwork for Chronic Pain

NCT06977984

Recruiting

The aim of the proposed research is to iteratively develop, pilot test, and refine an integrative breathwork intervention that is suitable for group delivery to individuals with chronic pain. The intervention will be evaluated for feasibility, acceptability, and plausibility for clinically significant effects in people with chronic musculoskeletal pain.

Gender:

ALL

Ages:

Between 18 years and 70 years

Trial Updated:

06/27/2025

Locations: University of Florida Clinical Research Center, Gainesville, Florida

Conditions: Chronic Pain

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Tele-Collaborative Outreach to Rural Patients With Chronic Pain

NCT06091202

Recruiting

This is a randomized controlled trial comparing the effectiveness of a remotely delivered collaborative care intervention for chronic pain versus a minimally enhanced control group. The specific aims of the study are: (1) compare the effectiveness of tele-collaborative pain care vs. minimally enhanced usual care to improve pain interference over 12 months of follow-up, and (2) oversample women and rural veterans of minoritized race/ethnicity to test heterogeneity of treatment effects across birt... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/27/2025

Locations: VA Minneapolis Health Care System, Minneapolis, Minnesota +3 locations

Conditions: Chronic Pain

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A Mobile Intervention to Reduce Pain and Improve Health-III

NCT06623669

Recruiting

The experience of chronic pain powerfully and negatively affects quality of life and functional independence in aging. Unfortunately, while as many as three in four older adults experience chronic pain, few have access to effective non-pharmacological pain management strategies. Participating in regular physical activity, avoiding sustained sitting, and maintaining a healthy weight are important and interrelated lifestyle inputs to chronic pain, and socially rich behavioral interventions informe... Read More

The experience of chronic pain powerfully and negatively affects quality of life and functional independence in aging. Unfortunately, while as many as three in four older adults experience chronic pain, few have access to effective non-pharmacological pain management strategies. Participating in regular physical activity, avoiding sustained sitting, and maintaining a healthy weight are important and interrelated lifestyle inputs to chronic pain, and socially rich behavioral interventions informed by contemporary theories of behavior change appear important for engaging in activity and healthy eating in the long term. Our group has demonstrated in a series of Stage I trials that a group-mediated behavioral intervention combining dietary behavior change and a physical activity program focused on moving often throughout the day contributes to meaningful weight loss, and lasting weight maintenance, with pilot data suggesting this may contribute to improved pain, physical function, and health-related quality of life among older adults with chronic pain. As these were NIH Stage I trials, there are several important gaps to be addressed in the present trial: (1) both studies of chronic pain recruited small samples and were 12 weeks in duration, limiting our ability to establish efficacy and the durability of changes to activity, HRQOL, and pain outcomes; (2) participants included anyone with chronic pain, regardless of pain type, a likely contributor to heterogeneous pain intensity and interference findings; and (3) the investigators have yet to examine behavioral maintenance. The overarching goal of the proposed Stage II "mobile intervention to reduce pain and improve health-III (MORPH-III)" is to establish the efficacy of the intervention for enhancing physical activity via steps (primary), and for reducing pain interference and body weight while enhancing physical function (secondary) among older adults with chronic knee or hip osteoarthritic (OA) pain. The investigators will recruit 200 older adults with knee or hip osteoarthritic pain to engage in a 6-month remotely delivered intervention comprising weekly group or individual intervention meetings plus brief individual goal-setting coaching calls. This will be followed by a 12-month no-contact maintenance period, where participants will attempt to sustain behavioral goals on their own. The Specific Aims are: Specific Aim 1: To examine the impact of MORPH on ActivPAL-assessed daily steps relative to an enhanced usual care control. Hypotheses: MORPH will significantly increase steps relative to control at month 6. Specific Aim 2: To examine the impact of MORPH on pain interference, change in body weight, and physical function relative to the enhanced usual care control. Hypotheses: MORPH will result in significant reductions in pain interference and body weight and improvement in physical function relative to control at month 6. Exploratory Aims: Aim 1: To investigate the impact of the MORPH intervention on steps, weight change, pain interference, and physical function at month 18. Aim 2: If the MORPH intervention results in reduced pain interference at 6 and/or 18 months, the investigators will examine the extent to which 6-month change in steps, weight, pain self-efficacy, and catastrophizing mediate change in interference at 6 and/or 18 months. Read Less

Gender:

ALL

Ages:

65 years and above

Trial Updated:

06/26/2025

Locations: Wake Forest University, Winston Salem, North Carolina

Conditions: Chronic Pain, Osteoarthritis, Obesity and Overweight, Inactivity

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