Chronic Pain Clinical Trials & Research Studies Near You (Updated 5/25)

Retrospective-Prospective PNS Study

NCT06845631

Recruiting

This is a retrospective-prospective study in which 40 patients have received a permanent Freedom PNS System. Subjects presented with chronic, intractable pain of peripheral nerve origin refractory to standard medical and/or surgical treatment. A retrospective chart review will be conducted to assess baseline and follow-up parameters in patients who have received a permanent implant with the Freedom PNS system for at least 12 months. Missing data might be collected after informed consent.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

02/24/2025

Locations: The Metrohealth System, Cleveland, Ohio

Conditions: Chronic Pain

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Overlapping Pain Trajectory Study

NCT05752396

Recruiting

The goal of this observational study is to learn about spatial and temporal nociceptive filtering in adolescents with chronic overlapping pain conditions (COPCs). The main questions it aims to answer are: 1. If spatial and temporal filtering of nociceptive information is disrupted in youth with COPCs compared with youth with localized pain conditions and healthy controls. 2. If disrupted nociceptive processing at baseline is associated with the transition from a single localized pain condition... Read More

Gender:

ALL

Ages:

Between 10 years and 19 years

Trial Updated:

08/20/2024

Locations: Cincinnati Children's Hospital, Cincinnati, Ohio

Conditions: Migraine, Musculoskeletal Pain, Functional Abdominal Pain Disorders, Chronic Pain, Widespread Chronic Pain, Low Back Pain, Healthy Volunteers

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Impact of 4PCP on Practitioner and Patient Outcomes

NCT05580419

Recruiting

Reducing opioid prescribing and improving outcomes in patients with chronic pain would benefit our nation. Neither addiction nor chronic pain spares any race, gender, or particular socio-economic status. This study is investigating a potentially inexpensive way of providing a previously costly service (the intensive chronic pain rehabilitation program), which is why insurers stopped covering it. Although it is unusual for an application from an academic institution to include a startup company (... Read More

Gender:

ALL

Ages:

Between 14 years and 80 years

Trial Updated:

07/03/2024

Locations: Case Western Reserve University, Cleveland, Ohio +3 locations

Conditions: Chronic Pain

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The PROACTIVE Study for Black Elders

NCT06512727

Recruiting

Chronic musculoskeletal pain (CMP), while a leading cause of physical disablement, is a neglected national health disparity issue in Black communities. The purpose of this study is to test a novel culturally congruent pain self-management intervention. A total of 120 persons aged 50-92, self-identifying as Black or African American having CMP will be invited to participate in this study. The primary outcome measured throughout this 3-year study is movement-evoked pain (MEP).

Gender:

ALL

Ages:

Between 50 years and 92 years

Trial Updated:

05/08/2025

Locations: University of Florida, Gainesville, Florida

Conditions: Musculoskeletal Pain, Chronic Pain, Osteoarthritis, Pain, Chronic, Movement Evoked Pain

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A DirEct to PatieNt Study in Chronic Pain

NCT05515341

Recruiting

To compile real-world, direct from patient clinical outcomes and objective metrics in patients who have received or plan to receive a commercially approved interventional medical device therapy/procedure for chronic pain in routine clinical practice.

Gender:

ALL

Ages:

22 years and above

Trial Updated:

05/08/2025

Locations: Boston Scientific Neuromodulation, Valencia, California

Conditions: Chronic Pain

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Patient Retrospective Outcomes (PRO)

NCT01550575

Recruiting

This study will evaluate de-identified (anonymous) data in subject medical charts to review the clinical outcomes of various treatment approaches in the treatment of chronic pain.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

05/08/2025

Locations: Lakeside Spine & Pain, Lake Havasu City, Arizona +137 locations

Lakeside Spine & Pain, Lake Havasu City, Arizona

Hope Research Institute, Phoenix, Arizona

Kern Neuroscience Institute, Bakersfield, California

Pain Consultants of San Diego, Chula Vista, California

Pain Medicine Associates, Inc., Fountain Valley, California

UCSD Medical Center - Jacobs Medical Center, La Jolla, California

California Orthopedics & Spine, Larkspur, California

MarinHealth Spine Institute, Larkspur, California

Newport Beach Headache and Pain, Newport Beach, California

Vitamed Research, Rancho Mirage, California

Pacific Pain Management, Inc., Ventura, California

IPM Medical Group Inc., Walnut Creek, California

Barolat Neuroscience, Denver, Colorado

Advanced Diagnostic Pain Treatment Centers, New Haven, Connecticut

South Lake Pain Institute, Inc, Clermont, Florida

Florida Spine Specialists, Fort Lauderdale, Florida

Louis J. Raso, MD, PA, Jupiter, Florida

Florida Pain Institute, Merritt Island, Florida

Advanced Interventional Pain Management and Research Clinic, Inc., Miami Gardens, Florida

Florida Pain Clinic, Ocala, Florida

Orthomicrospine, Pensacola, Florida

HCA Florida West Orthopedic Specialists, Pensacola, Florida

West Florida Orthopedics and Spine Surgery, Pensacola, Florida

Interventional Spine and Pain Institute, Vero Beach, Florida

Orthopedic Research Foundation, Savannah, Georgia

Centurion Spine and Pain, Waycross, Georgia

Tripler Army Medical Center, Honolulu, Hawaii

Pain and Spine Specialists of Idaho, Idaho Falls, Idaho

North Idaho Day Surgery, Post Falls, Idaho

Northwestern Memorial Hospital, Chicago, Illinois

Summit Research Institute, Fort Wayne, Indiana

Henry Community Health, New Castle, Indiana

Precision Spine Care, Overland Park, Kansas

Willis-Knighton River Cities Clinical Research Center, Shreveport, Louisiana

Pain and Spine Specialist of Maryland, Mount Airy, Maryland

Michigan Orthopedic Center, Lansing, Michigan

Multidisciplinary Pain Management Services, Okemos, Michigan

Forest Health Medical Center, Ypsilanti, Michigan

Twin Cities Pain Clinic & Surgery Center, Edina, Minnesota

NeuroSpecs-Gulfport Performance Spine, Gulfport, Mississippi

Comprehensive Pain & Rehabilitation, Pascagoula, Mississippi

Saint Louis Pain Consultants, Chesterfield, Missouri

Mercy Medical Research Institute, Springfield, Missouri

Albany Medical Center, Albany, New York

Jeffrey M. Epstein, M.D. PC, Babylon, New York

Montefiore Medical Center, Bronx, New York

Spine and Skeletal Pain Medicine, Utica, New York

Integrative Pain and Wellness Associates, Williamsville, New York

Vidant Roanoke - Chowan Hospital Pain Center, Ahoskie, North Carolina

Carolinas Research Institute, PLLC, Huntersville, North Carolina

Crystal Coast Pain Management, New Bern, North Carolina

Piedmont Interventional Pain Care, Salisbury, North Carolina

The Center for Clinical Research, LLC, Winston-Salem, North Carolina

Interventional Pain and Spine, Cincinnati, Ohio

University Hospitals of Cleveland, Cleveland, Ohio

Orthopaedic and Spine Center, Dublin, Ohio

Cincinnati Comprehensive Pain Center, Fairfield, Ohio

Western Reserve Spine and Pain Institute, Kent, Ohio

Interventional Pain Consultants, Toledo, Ohio

Toledo Clinic, Toledo, Ohio

University of Toledo Medical Center, Toledo, Ohio

Pacific Sports and Spine, LLC, Eugene, Oregon

Pain Specialists of Southern Oregon, Medford, Oregon

Quave Clinic, Medford, Oregon

Southern Oregon Orthopedics, Medford, Oregon

Summit Spine, Portland, Oregon

Geisinger Medical Center, Danville, Pennsylvania

Florence Neurosurgery and Spine, Florence, South Carolina

PCPMG Clinical Research Unit, LLC, Greenville, South Carolina

Interventional Spine and Pain Center, Manchester, Tennessee

Comprehensive Pain & Neurology Center, Murfreesboro, Tennessee

Pain Center Physicians, Austin, Texas

Balcones Pain Consultants, Austin, Texas

KSF Orthopaedics, Houston, Texas

Central Texas Pain Institute, Killeen, Texas

Advanced Spine Pain Solutions, Laredo, Texas

Spine Team Texas, Southlake, Texas

Space City Pain Specialists, Webster, Texas

University of Utah Orthopaedic Center, Salt Lake City, Utah

Carilion Roanoke Memorial Hospital, Roanoke, Virginia

EvergreenHealth Pain Care, Kirkland, Washington

Mind Your Body Institute, Seattle, Washington

Northwest Pain Care, Spokane, Washington

West Virginia University Hospitals, Morgantown, West Virginia

Interventional Pain Specialists of Wisconsin, Rice Lake, Wisconsin

Berwick Pain Management, Berwick, Not set

Hunter Pain Clinic, Broadmeadow, Not set

Monash Clinical Research, Caulfield South, Not set

Green Lizard Science, Claremont, Not set

Sydney Spine and Pain Pty Ltd, Hurstville, Not set

Sunshine Coast Clinical Research, Noosa Heads, Not set

Womens Health and Research Institute of Australia, Sydney, Not set

Pain Medicine of South Australia, Wayville, Not set

Clinique Saint-Pierre Ottignies, Ottignies, Not set

Clinique de la Sauvegarde, Lyon, Not set

Hopital Prive du Confluent SAS, Nantes, Not set

Fondation Ophtalmologique Adolphe de Rothschild, Paris, Not set

CHU La Miletrie, Poitiers, Not set

CHU de Nantes-Hopital Laennec, Saint-Herblain, Not set

Hopital Foch, Suresnes, Not set

University Berlin, Charite Virchow Standort, Wedding, Berlin-Wedding, Not set

Inter Neuro, Berlin, Not set

Uniklinik Köln, Cologne, Not set

Universitaetsklinikum Dusseldorf, Duesseldorf, Not set

St. Marien-Hospital Hamm, Hamm, Not set

Pres. Osp. Civile Santi Antonio e Biagio, Alessandria, Not set

Az. Osp. Monaldi, Napoli, Not set

Ospedale San Giuliano, Rionero In Vulture, Not set

Ospedale S. Giovanni Addolorata, Rome, Not set

Policlinico Universitario Agostino Gemelli, Rome, Not set

Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Not set

Alrijne Ziekenhuis Leiderdorp, Leiderdorp, Not set

Ziekenhuis Rijnstate, Velp, Not set

Ponce Interventional Pain Center, Ponce, Not set

Hospital De Bellvitge, Barcelona, Not set

H. Puerta Del Mar, Cadiz, Not set

Complejo Hospitalario Universitario de Cartagena, Cartagena, Not set

Hospital Universitario Doctor Jose Molina Orosa, Las Palmas, Not set

Hospital San Pedro, Logroño, Not set

Fundacion Jimenez Diaz, Madrid, Not set

Hospital Clinico San Carlos, Madrid, Not set

Hospital La Paz, Madrid, Not set

Hospital Universitario Quiron Madrid, Madrid, Not set

Hospital Puerta de Hierro, Majadahonda, Not set

Complexo Hospitalario Universitario de Ourense (CHUO), Orense, Not set

Hospital Virgen Del Rocio, Sevilla, Not set

H. Clinico Universitario, Valencia, Not set

Hospital de la Ribera, Valencia, Not set

Hospital Universitario La Fe, Valencia, Not set

Sahlgrenska University Hospital, Goeteborg, Not set

La Tour Hospital, Meyrin, Not set

Ospedale Regionale di Lugano, Viganello, Not set

Basildon and Thurrock University Hospitals NHS, Basildon, Not set

Southmead Hospital Bristol, Bristol, Not set

Royal Devon & Exeter Hospital, Exeter, Not set

The General Infirmary, Leeds, Not set

St. Bartholomews Hospital, London, Not set

James Cook University Hospital, Middlesbrough, Not set

Conditions: Chronic Pain

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Tele-Collaborative Outreach to Rural Patients With Chronic Pain

NCT06091202

Recruiting

This is a randomized controlled trial comparing the effectiveness of a remotely delivered collaborative care intervention for chronic pain versus a minimally enhanced control group. The specific aims of the study are: (1) compare the effectiveness of tele-collaborative pain care vs. minimally enhanced usual care to improve pain interference over 12 months of follow-up, and (2) oversample women and rural veterans of minoritized race/ethnicity to test heterogeneity of treatment effects across birt... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

05/06/2025

Locations: VA Minneapolis Health Care System, Minneapolis, Minnesota +3 locations

Conditions: Chronic Pain

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Anatomical and Functional Imaging Correlates of Chronic Pain in Cerebral Palsy

NCT05197946

Recruiting

The investigators hope to use MRI biomarkers to identify and characterize sensorimotor network disruption patterns associated with chronic pain and sensory deficits in CP. Investigators will use existing information in the medical record as well as subjective reports from interview, physical exam data, and anatomical and functional MRI data to non-invasively identify brain injury correlates of pain and sensory deficits.

Gender:

ALL

Ages:

8 years and above

Trial Updated:

05/01/2025

Locations: F.M. Kirby Center, Baltimore, Maryland +3 locations

Conditions: Cerebral Palsy, Chronic Pain

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Placebo Impacts Sleep and Pain Modulation in Chronic Pain

NCT06225817

Recruiting

The goal of this free-choice parallel design clinical trial is to examine the potential beneficial effects of using open-label placebo (OLP) in improving chronic pain related outcomes and sleep quality in people with temporomandibular disorders. This study will enroll a cohort of participants with temporomandibular disorders (TMD) which lasts for more than 3 months. The main questions it aims to answer are: 1. Will participants with TMD be more likely to take open-label placebo pills if they ar... Read More

The goal of this free-choice parallel design clinical trial is to examine the potential beneficial effects of using open-label placebo (OLP) in improving chronic pain related outcomes and sleep quality in people with temporomandibular disorders. This study will enroll a cohort of participants with temporomandibular disorders (TMD) which lasts for more than 3 months. The main questions it aims to answer are: 1. Will participants with TMD be more likely to take open-label placebo pills if they are introduced to the effects of placebo (e.g., going through an expectation management session)? 2. Will taking open-label placebo plus expectation management improve chronic pain related outcomes, such as chronic pain intensity, interference, levels of anxiety and depression, in the cohort of TMD? 3. Will open-label placebo plus expectation management improve sleep quality in participants suffering from TMD? To answer the above questions, participants with TMD will be randomly assigned to three groups: 1. Open-label placebo plus expectation management group, where participants will complete a 1-hour discussion session about their expectations toward open-lable placebo intervention, and then take 1 open-labe placebo pill per day for a total of 45 days. 2. Open-label placebo only group where participants will be asked to take open-label placebo pills, one pill per day, for a total of 45 days. 3. standard of care group where participants will maintain their usual care without introducing open-label placebo to them during the 45 days monitoring. Researchers will compare the chronic pain intensity, interference, mood, anxiety, and sleep quality between the open-label placebo group and the wait-list group. Daily chronic pain will be measured using visual analog scale (VAS) ranging from 0=no pain at all to 100=maximum tolerable pain. Chronic pain interference using Patient-Reported Outcomes Measurement Information System (PROMIS) pain interference and pain behavior. Anxiety and depression will be measured using PROMIS-anxiety, and PROMIS-depression scales respectively. Finally, sleep quality will be quantified using the objective measurement Motion Watch during the 45 days intervention and monitoring. In order to have a rigorous measurement of the baseline pain and sleep fluctuation, this study will include a 7-day phenotyping period before the starting of the 45-day intervention and monitoring. During the 7-day phenotyping period, participants will record their daily chronic pain and sleep quality using polysomnography. Read Less

Gender:

ALL

Ages:

Between 18 years and 88 years

Trial Updated:

04/30/2025

Locations: University of Maryland Baltimore School of Nursing, Baltimore, Maryland

Conditions: Headache, Chronic Pain

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Divided or Single Exposure (DOSE) Study

NCT05459402

Recruiting

This study will evaluate whether once versus twice daily dosing of methadone will be an effective method for managing comorbid pain and opioid use disorder.

Gender:

ALL

Ages:

Between 18 years and 100 years

Trial Updated:

04/28/2025

Locations: Addiction Treatment Services (ATS), Baltimore, Maryland

Conditions: Opioid Use Disorder, Chronic Pain, Methadone

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STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis

NCT05603702

Recruiting

The investigators propose to conduct a dose-escalation trial of an FDA-approved antiepileptic drug, lacosamide, added to opioid therapy in patients with chronic abdominal pain from chronic pancreatitis (CP). This pilot trial will test the feasibility of the study design and provide reassurance regarding the tolerability and safety of lacosamide used concomitantly with opioids in this patient population to reduce the condition known clinically as opioid-induced hyperalgesia (OIH).

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/27/2025

Locations: Stanford University, Stanford, California +4 locations

Conditions: Chronic Pain, Chronic Pain Syndrome, Chronic Pancreatitis, Hyperalgesia, Opioid Use Disorder, Opioid-Related Disorders, Opioid Dependence, Chronic Abdominal Pain, ERCP, Pancreatic Surgery

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Moderators and Mediators (M & M Trial) of Psychosocial Treatments of Chronic Pain

NCT06044649

Recruiting

Chronic musculoskeletal pain (CP) is a major public health concern. Psychosocial treatments have been shown to be efficacious when compared to largely inert control conditions, but they are characterized by modest effects on primary outcomes. One strategy to boost efficacy is to increase our understanding of treatment mediators. Studies of mediators that directly compare different treatments with each other are needed to determine which mediators are treatment-specific, which are shared across t... Read More

Chronic musculoskeletal pain (CP) is a major public health concern. Psychosocial treatments have been shown to be efficacious when compared to largely inert control conditions, but they are characterized by modest effects on primary outcomes. One strategy to boost efficacy is to increase our understanding of treatment mediators. Studies of mediators that directly compare different treatments with each other are needed to determine which mediators are treatment-specific, which are shared across treatments, and which contribute the most to clinical outcomes. Another strategy is to identify the patient characteristics that moderate treatment responses. Research is needed that is guided by theoretical models and that tests moderators across multiple treatments. Identifying subgroups of patients more likely to respond to one or another treatment can advance precision medicine by informing a priori patient-treatment matches that can optimize treatment effects. To accomplish these goals, the authors will conduct a randomized clinical trial to compare the mediators and moderators of the clinical effects of Cognitive-Behavioral Therapy (CBT), Acceptance and Commitment Therapy (ACT), and Emotional Awareness and Expression Therapy (EAET) on adults with chronic spinal (axial) pain. Following baseline assessment of outcome variables as well as potential mediators and moderators, 460 participants will be randomized to CBT, ACT, EAET, or treatment-as-usual control (TAU). The three treatments will be conducted as individual therapy provided weekly for 8 weeks via telehealth. The researchers will conduct weekly assessments of both potential mediators and outcomes, as well as post-treatment and 6-month follow-up assessments. The goal of the study is to identify the most powerful treatment mechanisms - specific and shared -- and reveal for whom the mediator-outcome pathways are strongest.This project can increase the effects of our psychosocial chronic pain treatments by identifying the most effective treatment mechanisms and by informing patient-treatment matches that can optimize treatment effects. Read Less

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/24/2025

Locations: Rush University Medical Center, Chicago, Illinois +1 locations

Conditions: Chronic Pain, Neck Pain, Back Pain

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Chronic Pain Clinical Trials

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