There are currently 147 active clinical trials seeking participants for Chronic Pain research studies. The states with the highest number of trials for Chronic Pain participants are California, Florida, Texas and New York.
Retrospective-Prospective PNS Study
NCT06845631
Recruiting
This is a retrospective-prospective study in which 40 patients have received a permanent Freedom PNS System. Subjects presented with chronic, intractable pain of peripheral nerve origin refractory to standard medical and/or surgical treatment. A retrospective chart review will be conducted to assess baseline and follow-up parameters in patients who have received a permanent implant with the Freedom PNS system for at least 12 months. Missing data might be collected after informed consent.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/24/2025
Locations: The Metrohealth System, Cleveland, Ohio
Conditions: Chronic Pain
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Overlapping Pain Trajectory Study
NCT05752396
Recruiting
The goal of this observational study is to learn about spatial and temporal nociceptive filtering in adolescents with chronic overlapping pain conditions (COPCs). The main questions it aims to answer are: 1. If spatial and temporal filtering of nociceptive information is disrupted in youth with COPCs compared with youth with localized pain conditions and healthy controls. 2. If disrupted nociceptive processing at baseline is associated with the transition from a single localized pain condition... Read More
Gender:
ALL
Ages:
Between 10 years and 19 years
Trial Updated:
08/20/2024
Locations: Cincinnati Children's Hospital, Cincinnati, Ohio
Conditions: Migraine, Musculoskeletal Pain, Functional Abdominal Pain Disorders, Chronic Pain, Widespread Chronic Pain, Low Back Pain, Healthy Volunteers
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Impact of 4PCP on Practitioner and Patient Outcomes
NCT05580419
Recruiting
Reducing opioid prescribing and improving outcomes in patients with chronic pain would benefit our nation. Neither addiction nor chronic pain spares any race, gender, or particular socio-economic status. This study is investigating a potentially inexpensive way of providing a previously costly service (the intensive chronic pain rehabilitation program), which is why insurers stopped covering it. Although it is unusual for an application from an academic institution to include a startup company (... Read More
Gender:
ALL
Ages:
Between 14 years and 80 years
Trial Updated:
07/03/2024
Locations: Case Western Reserve University, Cleveland, Ohio +3 locations
Conditions: Chronic Pain
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Equity Using Interventions for Pain and Depression
NCT06500780
Recruiting
This project is part of the NIH Helping to End Addiction Long-term (HEAL) initiative (https://heal.nih.gov/). This randomized controlled trial (RCT) is phase 2 of a two-phase, 5-year project with the overarching goal of testing a decision aid (DA)/coaching intervention, tailored to Black patients with comorbid chronic pain and depression, to encourage use of and adherence to nonpharmacological pain treatments (NPTs). This 2-arm trial will randomize 304 patients with comorbid chronic musculoskel... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/15/2025
Locations: Eskenazi Health Primary Care, Indianapolis, Indiana
Conditions: Chronic Pain, Musculoskeletal Pain, Depression, Health Equity
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SCS for Patient With Painful Diabetic Neuropathy and Peripheral Arterial Disease
NCT06480786
Recruiting
The study involves permanent spinal cord stimulator (SCS) placement in participants with peripheral arterial disease (PAD) and painful diabetic neuropathy (PDN). Participants will be between 19 and 89 years old, have diabetes with symptoms of neuropathy, and have a starting pain level of at least 5 cm on a visual pain scale. They must also have PAD, confirmed by an ankle-brachial index under 0.90 or vascular imaging, and experience pain from walking with a pain level of at least 6 cm for at leas... Read More
Gender:
ALL
Ages:
Between 19 years and 89 years
Trial Updated:
04/15/2025
Locations: University of Nebraska Medical Center, Omaha, Nebraska
Conditions: Peripheral Arterial Disease, Painful Diabetic Neuropathy, Diabetes Mellitus, Type 2, Chronic Pain, Spinal Cord Stimulation, Chronic Pain Syndrome, Limb Pain
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Neuroimaging of Opioid Phase (OPAL)
NCT05905419
Recruiting
The purpose of this study is to compare activity in the brains of female adults with chronic pain and/or opioid use, and healthy female adults that may help to develop new and targeted treatments for adults with chronic pain and alternatives to opioid therapy.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/11/2025
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Chronic Pain, Opioid Use
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Matching Adults to Treatments for Chronic Pain (MATCH) Study
NCT05699252
Recruiting
Chronic pain is a prevalent, disabling problem affecting as many as 50% of men and 75% of women Veterans. Cognitive Behavioral Therapy (CBT) is the current gold standard treatment for chronic pain. However, while some individuals do respond to CBT, many individuals do not obtain meaningful benefit. As a result, the average response to CBT treatment in groups of individuals with chronic pain is only modest. To address the need for effective treatments, the investigators have developed and adapte... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/11/2025
Locations: University of Washington, Ninth and Jefferson Building, Seattle, Washington +2 locations
Conditions: Chronic Pain
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Chronic Pain Management In Primary Care Using Behavioral Health Consultants
NCT04680000
Recruiting
The purpose of this randomized pragmatic trial is to assess the effect of monthly booster contacts on long-term Brief Cognitive Behavioral Therapy for Chronic Pain (BCBT-CP) pain outcomes compared to BCBT-CP without a booster in 716 Military Health Systems (MHS) beneficiaries referred to a Behavioral Health Consultant (BHC) for pain management using BCBT-CP. Patients will be randomly assigned to receive either standard BCBT-CP (working with a BHC in the medical home clinic) or standard BCBT-CP w... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/10/2025
Locations: Uniformed Services University for the Health Sciences, Bethesda, Maryland +4 locations
Conditions: Chronic Pain
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Patient Retrospective Outcomes (PRO)
NCT01550575
Recruiting
This study will evaluate de-identified (anonymous) data in subject medical charts to review the clinical outcomes of various treatment approaches in the treatment of chronic pain.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/09/2025
Locations: Lakeside Spine & Pain, Lake Havasu City, Arizona +137 locations
Conditions: Chronic Pain
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HOnest Placebos With Explanations: Evaluating Open-Label Placebos for Chronic Pain
NCT06931158
Recruiting
The goal of this clinical trial is to examine the effect of rationale condition when taking open-label placebos on pain by 1) comparing each rationale to the no rationale control condition and the no treatment control condition; and 2) comparing the rationale conditions to each other. We also aim to examine the effect of rationale condition on prescription opioid use by 1) comparing each rationale to the no rationale control condition and the no treatment control condition; and 2) comparing the... Read More
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
04/08/2025
Locations: Rhode Island Hospital, Providence, Rhode Island
Conditions: Chronic Low-back Pain, Chronic Pain
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A DirEct to PatieNt Study in Chronic Pain
NCT05515341
Recruiting
To compile real-world, direct from patient clinical outcomes and objective metrics in patients who have received or plan to receive a commercially approved interventional medical device therapy/procedure for chronic pain in routine clinical practice.
Gender:
ALL
Ages:
22 years and above
Trial Updated:
04/02/2025
Locations: Boston Scientific Neuromodulation, Valencia, California
Conditions: Chronic Pain
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Managing Chronic Tendon Pain by Metformin
NCT06100822
Recruiting
The purpose of the current exploratory clinical trial is to determine the effect of oral ingestion of metformin (OIM) in non-diabetic patients with chronic Achilles tendon pain. The trial has two aims; 1) to assess the effects of OIM treatment on tendon pain, and 2) to determine the effects of OIM capsules on tendon healing and repair. Twenty participants will be treated with metformin capsules for 16 weeks combined with a home exercise program. A comparison group of 20 participants will be trea... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
04/01/2025
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Tendinopathy, Chronic Pain, Achilles Tendinopathy
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