Chronic Pain Clinical Trials & Research Studies Near You (Updated 6/25)

Telehealth for Pain and Unhealthy Drinking Among PLWH

NCT05503173

Recruiting

This randomized controlled trial is a between-groups design to compare the Motivational and Cognitive Behavioral Management for Alcohol and Pain (MCBMAP) Intervention to a Brief Advice and Information Control condition. Two-hundred and fifty participants who have HIV with moderate or greater chronic pain will be randomized for the trial. Recruitment will take place through digital media. A unique feature of this intervention trial is that most of the procedures will be conducted remotely which... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/14/2025

Locations: Charles River Campus, Boston University, Psychology Department- remote study, Boston, Massachusetts

Conditions: HIV, Chronic Pain, Unhealthy Alcohol Use

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Healing Opioid Misuse and Pain Through Engagement (HOPE) Trial

NCT05571917

Recruiting

This study is a multisite randomized clinical trial of a treatment designed to reduce pain interference while simultaneously addressing relapse prevention among individuals who have co-occurring chronic pain and Opioid Use Disorder (OUD). This study will recruit approximately 160 individuals who are currently being treated in clinics specializing in the physician management of OUD. To increase generalizability of study findings and increase internal validity of the physician management component... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/11/2025

Locations: University of Michigan, Ann Arbor, Michigan +1 locations

Conditions: Opioid Use Disorder, Chronic Pain

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Opioids, Low Nicotine Cigarettes, and Chronic Pain

NCT06747871

Recruiting

The purpose of this study is to evaluate the effects of switching to very low nicotine content (VLNC) cigarettes versus normal nicotine content (NNC) cigarettes on craving, withdrawal, and pain among individuals with chronic pain who smoke cigarettes daily and are attending office-based buprenorphine treatment (OBBT).

Gender:

ALL

Ages:

21 years and above

Trial Updated:

06/11/2025

Locations: North Pavilion, Durham, North Carolina

Conditions: Chronic Pain, Tobacco Use, Opioid Substitution Treatment

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Pain Care at Home to Amplify Function (Pain CHAMP)

NCT05333341

Recruiting

This project aims to test simultaneously the effectiveness of telemedicine and collaborative management (TCM) vs. TCM plus Cooperative Pain Education and Self-Management (COPES) on patient level outcomes and the impact of site-tailored Implementation Facilitation to work toward long term opioid therapy dose reduction. Pain CHAMP is a patient-level randomized hybrid II effectiveness-implementation trial comparing TCM vs. TCM + COPES on the primary composite outcome of pain interference and OUD/mi... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/11/2025

Locations: Little Rock VAMC, Little Rock, Arkansas +2 locations

Conditions: Opioid Use Disorder, Opioid Misuse, Chronic Pain

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Patient Retrospective Outcomes (PRO)

NCT01550575

Recruiting

This study will evaluate de-identified (anonymous) data in subject medical charts to review the clinical outcomes of various treatment approaches in the treatment of chronic pain.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/10/2025

Locations: Lakeside Spine & Pain, Lake Havasu City, Arizona +140 locations

Lakeside Spine & Pain, Lake Havasu City, Arizona

Hope Research Institute, Phoenix, Arizona

Kern Neuroscience Institute, Bakersfield, California

Pain Consultants of San Diego, Chula Vista, California

Pain Medicine Associates, Inc., Fountain Valley, California

UCSD Medical Center - Jacobs Medical Center, La Jolla, California

California Orthopedics & Spine, Larkspur, California

MarinHealth Spine Institute, Larkspur, California

Loma Linda University Medical Center, Loma Linda, California

Newport Beach Headache and Pain, Newport Beach, California

Vitamed Research, Rancho Mirage, California

Pacific Pain Management, Inc., Ventura, California

IPM Medical Group Inc., Walnut Creek, California

Barolat Neuroscience, Denver, Colorado

Advanced Diagnostic Pain Treatment Centers, New Haven, Connecticut

South Lake Pain Institute, Inc, Clermont, Florida

Florida Spine Specialists, Fort Lauderdale, Florida

Louis J. Raso, MD, PA, Jupiter, Florida

Florida Pain Institute, Merritt Island, Florida

Advanced Interventional Pain Management and Research Clinic, Inc., Miami Gardens, Florida

Florida Pain Clinic, Ocala, Florida

Orthomicrospine, Pensacola, Florida

HCA Florida West Orthopedic Specialists, Pensacola, Florida

West Florida Orthopedics and Spine Surgery, Pensacola, Florida

Interventional Spine and Pain Institute, Vero Beach, Florida

Orthopedic Research Foundation, Savannah, Georgia

Centurion Spine and Pain, Waycross, Georgia

Tripler Army Medical Center, Honolulu, Hawaii

Pain and Spine Specialists of Idaho, Idaho Falls, Idaho

North Idaho Day Surgery, Post Falls, Idaho

Northwestern Memorial Hospital, Chicago, Illinois

Summit Research Institute, Fort Wayne, Indiana

Henry Community Health, New Castle, Indiana

Precision Spine Care, Overland Park, Kansas

Willis-Knighton River Cities Clinical Research Center, Shreveport, Louisiana

Pain and Spine Specialist of Maryland, Mount Airy, Maryland

Michigan Orthopedic Center, Lansing, Michigan

Multidisciplinary Pain Management Services, Okemos, Michigan

Forest Health Medical Center, Ypsilanti, Michigan

Twin Cities Pain Clinic & Surgery Center, Edina, Minnesota

NeuroSpecs-Gulfport Performance Spine, Gulfport, Mississippi

Comprehensive Pain & Rehabilitation, Pascagoula, Mississippi

Saint Louis Pain Consultants, Chesterfield, Missouri

Mercy Medical Research Institute, Springfield, Missouri

Albany Medical Center, Albany, New York

Jeffrey M. Epstein, M.D. PC, Babylon, New York

Montefiore Medical Center, Bronx, New York

Spine and Skeletal Pain Medicine, Utica, New York

Integrative Pain and Wellness Associates, Williamsville, New York

Vidant Roanoke - Chowan Hospital Pain Center, Ahoskie, North Carolina

Carolinas Research Institute, PLLC, Huntersville, North Carolina

Crystal Coast Pain Management, New Bern, North Carolina

Piedmont Interventional Pain Care, Salisbury, North Carolina

The Center for Clinical Research, LLC, Winston-Salem, North Carolina

Interventional Pain and Spine, Cincinnati, Ohio

University Hospitals of Cleveland, Cleveland, Ohio

Orthopaedic and Spine Center, Dublin, Ohio

Cincinnati Comprehensive Pain Center, Fairfield, Ohio

Western Reserve Spine and Pain Institute, Kent, Ohio

Interventional Pain Consultants, Toledo, Ohio

Toledo Clinic, Toledo, Ohio

University of Toledo Medical Center, Toledo, Ohio

Pacific Sports and Spine, LLC, Eugene, Oregon

Pain Specialists of Southern Oregon, Medford, Oregon

Quave Clinic, Medford, Oregon

Southern Oregon Orthopedics, Medford, Oregon

Summit Spine, Portland, Oregon

Geisinger Medical Center, Danville, Pennsylvania

Florence Neurosurgery and Spine, Florence, South Carolina

PCPMG Clinical Research Unit, LLC, Greenville, South Carolina

Interventional Spine and Pain Center, Manchester, Tennessee

Comprehensive Pain & Neurology Center, Murfreesboro, Tennessee

Pain Center Physicians, Austin, Texas

Balcones Pain Consultants, Austin, Texas

KSF Orthopaedics, Houston, Texas

Central Texas Pain Institute, Killeen, Texas

Advanced Spine Pain Solutions, Laredo, Texas

Spine Team Texas, Southlake, Texas

Space City Pain Specialists, Webster, Texas

University of Utah Orthopaedic Center, Salt Lake City, Utah

Carilion Roanoke Memorial Hospital, Roanoke, Virginia

EvergreenHealth Pain Care, Kirkland, Washington

Mind Your Body Institute, Seattle, Washington

Northwest Pain Care, Spokane, Washington

West Virginia University Hospitals, Morgantown, West Virginia

Interventional Pain Specialists of Wisconsin, Rice Lake, Wisconsin

Berwick Pain Management, Berwick, Not set

Hunter Pain Clinic, Broadmeadow, Not set

Monash Clinical Research, Caulfield South, Not set

Green Lizard Science, Claremont, Not set

Sydney Spine and Pain Pty Ltd, Hurstville, Not set

Sunshine Coast Clinical Research, Noosa Heads, Not set

Womens Health and Research Institute of Australia, Sydney, Not set

Pain Medicine of South Australia, Wayville, Not set

Clinique Saint-Pierre Ottignies, Ottignies, Not set

Clinique de la Sauvegarde, Lyon, Not set

Hopital Prive du Confluent SAS, Nantes, Not set

Fondation Ophtalmologique Adolphe de Rothschild, Paris, Not set

CHU La Miletrie, Poitiers, Not set

CHU de Nantes-Hopital Laennec, Saint-Herblain, Not set

Hopital Foch, Suresnes, Not set

University Berlin, Charite Virchow Standort, Wedding, Berlin-Wedding, Not set

Inter Neuro, Berlin, Not set

Uniklinik Köln, Cologne, Not set

Universitaetsklinikum Dusseldorf, Duesseldorf, Not set

St. Marien-Hospital Hamm, Hamm, Not set

Pres. Osp. Civile Santi Antonio e Biagio, Alessandria, Not set

Az. Osp. Monaldi, Napoli, Not set

AUSL della Romagna, Ravenna, Not set

Ospedale San Giuliano, Rionero In Vulture, Not set

Ospedale S. Giovanni Addolorata, Rome, Not set

Policlinico Universitario Agostino Gemelli, Rome, Not set

Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Not set

Alrijne Ziekenhuis Leiderdorp, Leiderdorp, Not set

Ziekenhuis Rijnstate, Velp, Not set

CHU Sao Joao, Porto, Not set

Ponce Interventional Pain Center, Ponce, Not set

Hospital De Bellvitge, Barcelona, Not set

H. Puerta Del Mar, Cadiz, Not set

Complejo Hospitalario Universitario de Cartagena, Cartagena, Not set

Hospital Universitario Doctor Jose Molina Orosa, Las Palmas, Not set

Hospital San Pedro, Logroño, Not set

Fundacion Jimenez Diaz, Madrid, Not set

Hospital Clinico San Carlos, Madrid, Not set

Hospital La Paz, Madrid, Not set

Hospital Universitario Quiron Madrid, Madrid, Not set

Hospital Puerta de Hierro, Majadahonda, Not set

Complexo Hospitalario Universitario de Ourense (CHUO), Orense, Not set

Hospital Virgen Del Rocio, Sevilla, Not set

H. Clinico Universitario, Valencia, Not set

Hospital de la Ribera, Valencia, Not set

Hospital Universitario La Fe, Valencia, Not set

Sahlgrenska University Hospital, Goeteborg, Not set

La Tour Hospital, Meyrin, Not set

Ospedale Regionale di Lugano, Viganello, Not set

Basildon and Thurrock University Hospitals NHS, Basildon, Not set

Southmead Hospital Bristol, Bristol, Not set

Royal Devon & Exeter Hospital, Exeter, Not set

The General Infirmary, Leeds, Not set

St. Bartholomews Hospital, London, Not set

James Cook University Hospital, Middlesbrough, Not set

Conditions: Chronic Pain

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Emotional Awareness and Expression Therapy for Chronic Pain and Opioid Use Disorder

NCT06865560

Recruiting

The study is intended to test whether a group-based Zoom behavioral treatment can help adults with chronic pain and opioid use disorder (OUD) learn effective strategies for reducing pain, disability and other problems that can come with these conditions (such as depression, anxiety, and difficulty managing emotions).

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/06/2025

Locations: The University of Michigan, Ann Arbor, Michigan

Conditions: Chronic Pain, Opioid Use Disorder

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Clinical Utility of Neurophysiological Measurements of ECAP-controlled Closed-loop SCS to Guide Treatment of Chronic Pain

NCT06229470

Recruiting

The purpose of this study is to evaluate the clinical utility of neurophysiological measurements of ECAP-controlled closed-loop SCS (i.e., neural panel metrics) to guide treatment of chronic pain of the trunk and/or limbs.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/06/2025

Locations: Lakeside Spine and Pain, Lake Havasu City, Arizona +24 locations

Lakeside Spine and Pain, Lake Havasu City, Arizona

Spanish Hills Interventional Pain Specialists, Camarillo, California

Pain Consultants of San Diego, La Mesa, California

Pacific Research Institute, Santa Rosa, California

Boomerang Healthcare, Walnut Creek, California

DBPS Research, Greenwood Village, Colorado

Pohlman Pain Associates, Delray Beach, Florida

Horizon Clinical Research, Jasper, Georgia

Rockford Pain Center, Rockford, Illinois

Goodman Campbell Brain and Spine, Carmel, Indiana

Metro Anesthesia & Pain Management, Des Moines, Iowa

Restorative Pain Institute, Louisville, Kentucky

Advanced Pain Institute, Hammond, Louisiana

Spine and Joint Institute, Glen Burnie, Maryland

Michigan Pain Specialists, Ann Arbor, Michigan

Pain Clinic of Michigan, Rochester Hills, Michigan

Tricity Research Center, LLC, Grand Island, Nebraska

Reno Tahoe Pain Associates, Reno, Nevada

Garden State Pain and Orthopedics, Clifton, New Jersey

Seaside Clinical Research Institute, Wilmington, North Carolina

Cleveland Clinic Foundation, Cleveland, Ohio

Premier Pain Treatment Institute, Loveland, Ohio

Carolinas Center for Advanced Management of Pain, Greenville, South Carolina

Institute of Precision Pain Medicine, Corpus Christi, Texas

Victoria Pain and Rehabilitation Center, Victoria, Texas

Conditions: Chronic Pain

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A DirEct to PatieNt Study in Chronic Pain

NCT05515341

Recruiting

To compile real-world, direct from patient clinical outcomes and objective metrics in patients who have received or plan to receive a commercially approved interventional medical device therapy/procedure for chronic pain in routine clinical practice.

Gender:

ALL

Ages:

22 years and above

Trial Updated:

06/06/2025

Locations: Boston Scientific Neuromodulation, Valencia, California

Conditions: Chronic Pain

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Brief Intervention for Chronic Pain and History of Stressful Experiences

NCT06983327

Recruiting

The goal of this study is to understand whether a brief, three session program can be helpful in reducing symptoms related to both chronic pain and stressful experiences/trauma.

Gender:

ALL

Ages:

21 years and above

Trial Updated:

06/06/2025

Locations: Brigham and Women's Hospital, Chestnut Hill, Massachusetts

Conditions: Chronic Pain, Trauma, Adverse Childhood Experiences

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Operant Conditioning of Sensory Brain Responses to Reduce Phantom Limb Pain in People With Limb Amputation

NCT05880251

Recruiting

The study will investigate the application of a non-pharmacological operant conditioning approach to reduce phantom limb pain (PLP). PLP afflicts 60-90% people who have lost a limb. It can last for years and lead to drug dependence, job loss, and poor quality of life. Current non-pharmacological interventions are encouraging but limited, and their efficacy remains unclear. Limb amputation is known to lead to abnormal sensorimotor reorganization in the brain. Multiple studies have shown that PLP... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/05/2025

Locations: Albany VA Medical Center Samuel S. Stratton, Albany, NY, Albany, New York

Conditions: Phantom Limb Pain After Amputation, Lower Limb Amputation, Upper Limb Amputation, Phantom Pain, Chronic Pain

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Placebo Impacts Sleep and Pain Modulation in Chronic Pain

NCT06225817

Recruiting

The goal of this free-choice parallel design clinical trial is to examine the potential beneficial effects of using open-label placebo (OLP) in improving chronic pain related outcomes and sleep quality in people with temporomandibular disorders. This study will enroll a cohort of participants with temporomandibular disorders (TMD) which lasts for more than 3 months. The main questions it aims to answer are: 1. Will participants with TMD be more likely to take open-label placebo pills if they ar... Read More

The goal of this free-choice parallel design clinical trial is to examine the potential beneficial effects of using open-label placebo (OLP) in improving chronic pain related outcomes and sleep quality in people with temporomandibular disorders. This study will enroll a cohort of participants with temporomandibular disorders (TMD) which lasts for more than 3 months. The main questions it aims to answer are: 1. Will participants with TMD be more likely to take open-label placebo pills if they are introduced to the effects of placebo (e.g., going through an expectation management session)? 2. Will taking open-label placebo plus expectation management improve chronic pain related outcomes, such as chronic pain intensity, interference, levels of anxiety and depression, in the cohort of TMD? 3. Will open-label placebo plus expectation management improve sleep quality in participants suffering from TMD? To answer the above questions, participants with TMD will be randomly assigned to three groups: 1. Open-label placebo plus expectation management group, where participants will complete a 1-hour discussion session about their expectations toward open-lable placebo intervention, and then take 1 open-labe placebo pill per day for a total of 45 days. 2. Open-label placebo only group where participants will be asked to take open-label placebo pills, one pill per day, for a total of 45 days. 3. standard of care group where participants will maintain their usual care without introducing open-label placebo to them during the 45 days monitoring. Researchers will compare the chronic pain intensity, interference, mood, anxiety, and sleep quality between the open-label placebo group and the wait-list group. Daily chronic pain will be measured using visual analog scale (VAS) ranging from 0=no pain at all to 100=maximum tolerable pain. Chronic pain interference using Patient-Reported Outcomes Measurement Information System (PROMIS) pain interference and pain behavior. Anxiety and depression will be measured using PROMIS-anxiety, and PROMIS-depression scales respectively. Finally, sleep quality will be quantified using the objective measurement Motion Watch during the 45 days intervention and monitoring. In order to have a rigorous measurement of the baseline pain and sleep fluctuation, this study will include a 7-day phenotyping period before the starting of the 45-day intervention and monitoring. During the 7-day phenotyping period, participants will record their daily chronic pain and sleep quality using polysomnography. Read Less

Gender:

ALL

Ages:

Between 18 years and 88 years

Trial Updated:

06/03/2025

Locations: University of Maryland Baltimore School of Nursing, Baltimore, Maryland

Conditions: Headache, Chronic Pain

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Divided or Single Exposure (DOSE) Study

NCT05459402

Recruiting

This study will evaluate whether once versus twice daily dosing of methadone will be an effective method for managing comorbid pain and opioid use disorder.

Gender:

ALL

Ages:

Between 18 years and 100 years

Trial Updated:

06/02/2025

Locations: Addiction Treatment Services (ATS), Baltimore, Maryland

Conditions: Opioid Use Disorder, Chronic Pain, Methadone

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Chronic Pain Clinical Trials

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