There are currently 178 active clinical trials seeking participants for Heart Failure research studies. The states with the highest number of trials for Heart Failure participants are California, Florida, Texas and Pennsylvania.
MRI to Predict Rejection and Failure in Transplant and Cardiomyopathy Patients
NCT03822442
Recruiting
Overall Research Strategy of this protocol is to refine and validate noninvasive CMR imaging sequences with invasive hemodynamic and pathology results to create a comprehensive, noninvasive, radiation-reduced regimen for pediatric cardiomyopathy and cardiac transplant assessment. We were the first to perform MR-guided cardiac catheterization in US children, and have accumulated the largest US experience, having performed over 75 procedures to date. Our unique experience puts us in strong positio... Read More
Gender:
ALL
Ages:
6 months and above
Trial Updated:
10/30/2024
Locations: Children's National Health System, Washington, District of Columbia
Conditions: Heart Failure, Cardiac Imaging Techniques, Congenital Heart Defects
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Enhanced Nutritional Optimization in LVAD Trial
NCT05655910
Recruiting
The goal of this clinical trial is to assess whether a peri-operative intervention with nutritional immune modulating intervention (Ensure Surgery Immunonutrition shake) has beneficial effects on the complex interplay between gut microbiome, systemic inflammation and malnutrition that is commonly present in advanced heart failure and the adverse events associated with left ventricular assist device (LVAD) placement in hospitalized advanced heart failure patients awaiting LVAD implantation. The m... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/29/2024
Locations: Columbia University Medical Center, New York, New York
Conditions: Heart Failure, Gut Microbiome, Nutritional Deficiency
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Lymphatic System Stimulation in Heart Failure
NCT05834400
Recruiting
The goal of this pilot clinical trial is to obtain preliminary data on the effects of lymphatic exercise training in patients with heart failure. The main question\[s\] it aims to answer are: 1. Does performing lymphatic exercise decrease fluid overload symptoms (shortness of breath, lower legs swelling, fatigue), thoracic fluid content, and body fluid level? 2. Does performing lymphatic exercise improve sleep and quality of life (QOL)? Participants with heart failure will be randomly assigned... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
10/24/2024
Locations: Cooper University Health Care (Cooper), Camden, New Jersey
Conditions: Heart Failure
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Inspiratory Muscle Training in HFpEF
NCT06510231
Recruiting
This study is being done to determine how inspiratory muscle training impacts inspiratory muscle function during exercise in heart failure patients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/10/2024
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Heart Failure
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Cardiac Power Output in Cardiogenic Shock Patients
NCT05700617
Recruiting
The main purpose of this study is to determine whether differences in myocardial reserve predict clinical outcomes for heart failure patients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/09/2024
Locations: The University of Chicago, Chicago, Illinois
Conditions: Heart Failure, Cardiogenic Shock
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Post Approval Study (PAS) of the OPTIMIZER Smart and CCM Therapy
NCT03970343
Recruiting
The OPTIMIZER Smart Post-Approval Study is a prospective, multi-center, non-randomized, single arm open label study of 620 subjects receiving an OPTIMIZER implant as standard of care. Patients to be included will have NYHA functional class III symptoms and a left ventricular ejection fraction of 25-45%
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/09/2024
Locations: CardioVascular Associates of Mesa (CVAM), Mesa, Arizona +92 locations
Conditions: Heart Failure
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Informational Nudge to Improve Heart Failure Prescribing
NCT05986695
Recruiting
This study addresses a critical gap of care for Veterans with heart failure (HF). Only 1/3 or fewer eligible Veterans are receiving recommended SGLT2 and MRA therapies that save lives and prevents HF hospitalizations. The investigators will compare the effect of clinician directed nudges as strategies to improve the health of Veterans with HF.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/08/2024
Locations: Southern Arizona VA Health Care System, Tucson, AZ, Tucson, Arizona
Conditions: Heart Failure
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Mechanisms of Diuretic Resistance in Heart Failure, Aim 3
NCT06209359
Recruiting
Randomized double-blind placebo-controlled crossover study design
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/03/2024
Locations: Yale University, New Haven, Connecticut
Conditions: Heart Failure, Diuretic Resistance
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Randomized Controlled Trial of urinE chemiStry Guided aCute heArt faiLure treATmEnt (ESCALATE)
NCT04481919
Recruiting
This is a randomized trial of protocolized diuretic therapy guided by urinary sodium compared to structured usual care in ED patients with AHF. Participants will be recruited following an initial standard evaluation in the ED and randomized in a 1:1 fashion to structured usual care or protocolized diuretic therapy guided by urinary sodium.
Gender:
ALL
Ages:
19 years and above
Trial Updated:
10/02/2024
Locations: VA Tennessee Valley Health Service, Nashville, Tennessee +1 locations
Conditions: Heart Failure, Acute Heart Failure
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Access BNP Clinical Enrollment Study
NCT06624293
Recruiting
The goal of this study is to collect blood from subjects with a suspicion of either new onset or worsened heart failure to be used for testing studies for a new product to aid in the diagnosis of heart failure.
Gender:
ALL
Ages:
22 years and above
Trial Updated:
10/01/2024
Locations: Loma Linda University Medical Center Department of Emergency Medicine, Loma Linda, California +16 locations
Conditions: Heart Failure
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A Study to Evaluate Breathing Muscle Training in Cardiac Rehab
NCT04984473
Recruiting
The purpose of this study is to understand if breathing muscle training combined with cardiac rehabilitation influences the blood flow and blood pressure response during exercise.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/26/2024
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Healthy, Heart Failure
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Empagliflozin in ESKD - A Feasibility Study
NCT05687058
Recruiting
The aim of this study is to learn about the safety of empagliflozin in dialysis patients as a preparation for a future large clinical trial. Empagliflozin has been approved by the Food and Drug Administration for the treatment of either type 2 diabetes, heart failure, or chronic kidney disease among patients not on dialysis. The use of empagliflozin has not been studied or approved among patients on dialysis for kidney failure because empagliflozin acts on the kidneys. However, recent experiment... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/11/2024
Locations: University of Mississippi Medical Center, Jackson, Mississippi +1 locations
Conditions: Kidney Failure, Chronic, Heart Failure
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