There are currently 170 active clinical trials seeking participants for Heart Failure research studies. The states with the highest number of trials for Heart Failure participants are California, Florida, Texas and New York.
Magnetic Resonance Elastography as a Method to Estimate Stiffness of Soft Tissues
NCT01757730
Recruiting
Magnetic resonance elastography is a novel non-invasive MRI technique to obtain stiffness of soft tissues such as liver, heart, kidneys, etc. In this imaging technique a person is laid in an MR scanner and a paddle (plastic drum) is put on the area of interest to send sound vibration via a speaker placed outside the scan room which is connecting plastic drum via a plastic tube. These vibrations are scanned using MRI to estimate the stiffness of soft tissues such as liver, heart, kidneys, breast... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/23/2023
Locations: The Ohio State University Wexner Medical Center, Columbus, Ohio
Conditions: Heart Failure, Liver Fibrosis, Cardiac Transplant Rejection, Aortic Aneurysms
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Early Assessment and Initiation of GuideLine-Directed Evidence-Based Management-HF
NCT06849752
Recruiting
EAGLE-HF (Early Assessment and initiation of GuideLine-directed Evidence-based management-HF) is a prospective single site study of a multinational, unblinded, randomized-controlled, longitudinal trial called SYMPHONY. Primary, secondary and exploratory outcomes that are part of SYMPHONY are not described herein as they replicate SYMPHONY outcomes. Data associated with SYMPHONY outcomes will be sent to the SYMPHONY coordinating center. In EAGLE-HF, site investigators will examine if a new-onset... Read More
Gender:
ALL
Ages:
40 years and above
Trial Updated:
03/17/2025
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Heart Failure, Socioeconomic Adversity
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Music Therapy to Address Patients' Journeys with Chronic Illness, Outcomes, and Readmission - MAJOR CHORD RCT
NCT06546319
Recruiting
Conduct a randomized trial (n = 60: with n = 30 receiving music therapy and n = 30 receiving usual care) to investigate the feasibility, acceptability, and preliminary efficacy of the MAJOR CHORD music therapy intervention compared to usual care on (a) health-related quality of life (e.g., physical function, depression, anxiety, fatigue, and pain interference), (b) perceived stress, (c) self-efficacy, and (d) 30-day readmission rates
Gender:
ALL
Ages:
Between 30 years and 89 years
Trial Updated:
10/01/2024
Locations: University Hospitals Cleveland Medical Center, Cleveland, Ohio
Conditions: Heart Failure, Chronic Obstructive Pulmonary Disease
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Physiological Effects Ketone Ester in Heart
NCT05924802
Recruiting
The study is aimed to phenotype with cardiac MRI the physiological effects of ketone esters on the heart. Patients with heart failure will be recruited and given ketone esters or placebo in a randomized fashion. Cardiac MRI will be performed at baseline and after 12weeks follow up.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/19/2024
Locations: Cardiovascular Innovation Research Center, Cleveland, Ohio
Conditions: Heart Failure
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Optimizing Beta Blocker Dosage in Women While Using the Wearable Cardioverter Defibrillator
NCT04504188
Recruiting
The primary objective of this pilot study is to document the percentage achievement in effective HR control (average nighttime HR \< 70 bpm) during WCD use in a cohort of female patients with cardiomyopathy in an outpatient setting using continuous heart rate (HR) trends data from the WCD to optimize BB/ivabradine dosage, as compared to a prior historical control.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
07/23/2024
Locations: TriHealth Hatton Research Institute, Cincinnati, Ohio +3 locations
Conditions: Cardiomyopathies, Heart Failure
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Implantation of a Permanent Interatrial Shunt to Reduce Left Atrial Filling Pressures Following MitraClip
NCT04729933
Recruiting
This is an investigator initiated, prospective study to demonstrate the safety and feasibility of implantation of the V-Wave Interatrial Shunt System (herein called the "V-Wave Shunt" in patients immediately following percutaneous mitral valve repair using the MitraClip system.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/19/2024
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Heart Failure, Mitral Regurgitation
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Development of CIRC Technologies
NCT05654272
Recruiting
Cardiovascular disease is the leading cause of death worldwide. Advanced cardiovascular imaging using Magnetic Resonance Imaging (MRI) has proven to be effective in providing gold standard myocardial tissue characterization. Moreover, the intrinsic advantage of MRI's lack of exposure to ionizing radiation is particularly beneficial. At the same time, blood work can be very useful in early detection of certain cardiomyopathy, such as amyloid. However, there is a lack of agreement of on which mark... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/05/2024
Locations: Cardiovascular Innovation Research Center, Cleveland, Ohio
Conditions: Cardiovascular Diseases, Heart Failure, Ischemic Heart Disease, Non-ischemic Cardiomyopathy, Valvular Heart Disease, Metabolic Cardiomyopathy, Congenital Heart Disease, Aortic Diseases, Atrial Fibrillation, Ventricular Fibrillation
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CV Imaging of Metabolic Interventions
NCT05650307
Recruiting
Cardiovascular disease is the leading cause of death worldwide. It is becoming clearer that heart failure (HF) is closely associated with body's metabolism. Even before the heart becomes weaker, it responds to the stresses by changing the fuels it burns, which results in a reduction in the heart's metabolic efficiency that worsens the heart's condition. Since the heart burns so much fuel and consumes fats and carbohydrates along with other available substrates, any changes in its metabolic effic... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/05/2024
Locations: Cardiovascular Innovation Research Center, Cleveland, Ohio
Conditions: Bariatric Surgery Candidate, Heart Failure, Cardiovascular Diseases
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Screening for earlY Heart Failure Diagnosis and Management in Primary Care or at HOme Using Natriuretic Peptides and echocardiographY "SYMPHONY-HF"
NCT05919342
Recruiting
This is an international prospective, multicentre, unblinded, randomised-controlled trial. The primary aim is to assess a targeted screening strategy to detect undiagnosed heart failure in high-risk patients.
Gender:
ALL
Ages:
40 years and above
Trial Updated:
08/02/2023
Locations: Cleveland Clinic, Cleveland, Ohio +6 locations
Conditions: Heart Failure, Cardiovascular Diseases
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A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure
NCT06424288
Recruiting
This study is open to adults aged 18 or above legal age with heart failure. People can join the study if they have heart failure symptoms and a left ventricular ejection fraction (LVEF) of 40% or more. The purpose of this study is to find out whether vicadrostat (BI 690517) in combination with empagliflozin helps people with heart failure. Participants are put into 2 groups by chance. Every participant has an equal chance of being in each group. The groups are: * Vicadrostat and empagliflozin... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/27/2025
Locations: Pinnacle Research Group, LLC, Anniston, Alabama +588 locations
Conditions: Heart Failure
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Study to Evaluate Safety, Tolerability and Drug Levels of BMS-986435/MYK-224 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)
NCT06122779
Recruiting
The purpose of this study is to evaluate the safety, tolerability, and exposure-response (E-R) of BMS-986435/MYK-224 in participants with symptomatic Heart Failure with Preserved Ejection Fraction (HFpEF).
Gender:
ALL
Ages:
Between 40 years and 90 years
Trial Updated:
05/27/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama +114 locations
Conditions: Heart Failure
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Acalabrutinib Monotherapy vs Investigator's Choice of Treatment in Patients With CL Leukaemia and Heart Failure
NCT06651970
Recruiting
This will be a global Phase IV, open-label, randomised study to evaluate the safety and tolerability of acalabrutinib (monotherapy, 100 mg orally \[po\], twice daily \[bd\]) compared to investigator's choice of treatment, in patients with CLL (TN or R/R) and moderate to severe cardiac impairment. All patients will have cardiac impairment as defined by LVEF of \< 50%. Randomisation will be stratified by LVEF \> 40% vs ≤ 40% to stratify for moderate and severe cardiac impairment, which for this s... Read More
Gender:
ALL
Ages:
Between 18 years and 130 years
Trial Updated:
05/26/2025
Locations: Research Site, Charlotte, North Carolina +22 locations
Conditions: Chronic Lymphocytic Leukaemia, Heart Failure
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