There are currently 173 active clinical trials seeking participants for Heart Failure research studies. The states with the highest number of trials for Heart Failure participants are California, Florida, Texas and Pennsylvania.
Implantation of a Permanent Interatrial Shunt to Reduce Left Atrial Filling Pressures Following MitraClip
NCT04729933
Recruiting
This is an investigator initiated, prospective study to demonstrate the safety and feasibility of implantation of the V-Wave Interatrial Shunt System (herein called the "V-Wave Shunt" in patients immediately following percutaneous mitral valve repair using the MitraClip system.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/19/2024
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Heart Failure, Mitral Regurgitation
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CV Imaging of Metabolic Interventions
NCT05650307
Recruiting
Cardiovascular disease is the leading cause of death worldwide. It is becoming clearer that heart failure (HF) is closely associated with body's metabolism. Even before the heart becomes weaker, it responds to the stresses by changing the fuels it burns, which results in a reduction in the heart's metabolic efficiency that worsens the heart's condition. Since the heart burns so much fuel and consumes fats and carbohydrates along with other available substrates, any changes in its metabolic effic... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/05/2024
Locations: Cardiovascular Innovation Research Center, Cleveland, Ohio
Conditions: Bariatric Surgery Candidate, Heart Failure, Cardiovascular Diseases
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Development of CIRC Technologies
NCT05654272
Recruiting
Cardiovascular disease is the leading cause of death worldwide. Advanced cardiovascular imaging using Magnetic Resonance Imaging (MRI) has proven to be effective in providing gold standard myocardial tissue characterization. Moreover, the intrinsic advantage of MRI's lack of exposure to ionizing radiation is particularly beneficial. At the same time, blood work can be very useful in early detection of certain cardiomyopathy, such as amyloid. However, there is a lack of agreement of on which mark... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/05/2024
Locations: Cardiovascular Innovation Research Center, Cleveland, Ohio
Conditions: Cardiovascular Diseases, Heart Failure, Ischemic Heart Disease, Non-ischemic Cardiomyopathy, Valvular Heart Disease, Metabolic Cardiomyopathy, Congenital Heart Disease, Aortic Diseases, Atrial Fibrillation, Ventricular Fibrillation
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Music Therapy to Address Patients' Journeys With Chronic Illness, Outcomes, and Readmission
NCT06214325
Recruiting
Conduct a pilot study (n = 20) to explore the feasibility and acceptability of the MAJOR CHORD music therapy (MT) intervention (i.e., two in-person MT sessions prior to discharge and two virtual MT sessions post-discharge) and collection of patient-reported outcomes through 30 days after hospital discharge. The investigators will uncover any potential modifications that need to be made to the intervention and data collection process prior to initiating the randomized trial.
Gender:
All
Ages:
Between 40 years and 89 years
Trial Updated:
01/26/2024
Locations: University Hospitals Cleveland Medical Center, Cleveland, Ohio
Conditions: Heart Failure, Chronic Obstructive Pulmonary Disease
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Magnetic Resonance Elastography as a Method to Estimate Stiffness of Soft Tissues
NCT01757730
Recruiting
Magnetic resonance elastography is a novel non-invasive MRI technique to obtain stiffness of soft tissues such as liver, heart, kidneys, etc. In this imaging technique a person is laid in an MR scanner and a paddle (plastic drum) is put on the area of interest to send sound vibration via a speaker placed outside the scan room which is connecting plastic drum via a plastic tube. These vibrations are scanned using MRI to estimate the stiffness of soft tissues such as liver, heart, kidneys, breast... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
10/23/2023
Locations: The Ohio State University Wexner Medical Center, Columbus, Ohio
Conditions: Heart Failure, Liver Fibrosis, Cardiac Transplant Rejection, Aortic Aneurysms
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ALT-FLOW II Trial of the Edwards APTURE Transcatheter Shunt System
NCT05686317
Recruiting
This is a prospective, multi-center, randomized, sham-controlled clinical trial.
Gender:
All
Ages:
18 years and above
Trial Updated:
09/05/2023
Locations: The Ohio State University, Columbus, Ohio
Conditions: Heart Failure
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Screening for earlY Heart Failure Diagnosis and Management in Primary Care or at HOme Using Natriuretic Peptides and echocardiographY "SYMPHONY-HF"
NCT05919342
Recruiting
This is an international prospective, multicentre, unblinded, randomised-controlled trial. The primary aim is to assess a targeted screening strategy to detect undiagnosed heart failure in high-risk patients.
Gender:
All
Ages:
40 years and above
Trial Updated:
08/02/2023
Locations: Cleveland Clinic, Cleveland, Ohio +6 locations
Conditions: Heart Failure, Cardiovascular Diseases
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Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)
NCT05714085
Recruiting
This study aims to compare the efficacy of vericiguat versus placebo on change in n-terminal pro-brain natriuretic peptide (NTproBNP) from baseline to Week 16. The primary hypothesis is Vericiguat is superior to placebo in reducing NT-proBNP at Week 16.
Gender:
All
Ages:
Between 29 days and 17 years
Trial Updated:
06/20/2024
Locations: Loma Linda University Health System ( Site 0008), Loma Linda, California +65 locations
Conditions: Heart Failure, Left Ventricular Systolic Dysfunction
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Improving Cardiac Rehabilitation Exercise Using Target Heart Rate Trial
NCT05925634
Recruiting
The goal of this clinical trial is to compare two types of exercise prescriptions in cardiac rehabilitation eligible older adults (60 years or older) with heart disease. The investigators found in a single site pilot trial (insert NCTxxx) that one exercise prescription was better and are now repeating this study in a larger population at two sites (Baystate Medical Center, Springfield MA and Henry Ford Health System, Detroit MI). The main questions the investigators aim to answer are: Compare t... Read More
Gender:
All
Ages:
Between 60 years and 101 years
Trial Updated:
06/20/2024
Locations: Baystate Medical Center, Springfield, Massachusetts +1 locations
Conditions: Myocardial Infarction, Coronary Artery Bypass, Percutaneous Coronary Intervention, Heart Failure, Cardiac Valve Surgery
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A Study of LY3540378 in Participants With Worsening Chronic Heart Failure With Preserved Ejection Fraction (HFpEF)
NCT05592275
Recruiting
The main purpose of this study is to assess the efficacy and safety of LY3540378 in adults with worsening heart failure with preserved ejection fraction
Gender:
All
Ages:
18 years and above
Trial Updated:
06/19/2024
Locations: Valley Clinical Trials, Inc., Covina, California +130 locations
Conditions: Heart Failure, Heart Failure With Preserved Ejection Fraction
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A Study to Test Whether BI 690517 in Combination With Empagliflozin Helps People With Heart Failure
NCT06424288
Recruiting
This study is open to adults aged 18 or above legal age with heart failure. People can join the study if they have heart failure symptoms and a left ventricular ejection fraction (LVEF) of 40% or more. The purpose of this study is to find out whether BI 690517 in combination with empagliflozin helps people with heart failure. Participants are put into 2 groups by chance. Every participant has an equal chance of being in each group. The groups are: BI 690517 and empagliflozin group: participant... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
06/17/2024
Locations: Excel Medical Clinical Trials, LLC, Boca Raton, Florida
Conditions: Heart Failure
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Contrast Echocardiography During Exercise to Assess Pulmonary Blood Volume
NCT06195059
Recruiting
The purpose of this study is to evaluate whether pulmonary blood volume (PBV) derived from contrast echocardiography can serve as a non-invasive surrogate for invasive pulmonary artery wedge pressure (PAWP) during exercise. Also, to compare changes in PBV with exercise in patients with and without heart failure and pulmonary vascular disease.
Gender:
All
Ages:
18 years and above
Trial Updated:
06/17/2024
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Heart Failure, Pulmonary Vascular Disease
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