Heart Failure Clinical Trials

A listing of 172 Heart Failure clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.

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There are currently 172 active clinical trials seeking participants for Heart Failure research studies. The states with the highest number of trials for Heart Failure participants are California, Florida, Texas and New York.

Featured Trial

Paid Clinical Studies Nationwide

Recruiting

Nationwide clinical trials offered in your area. Some trials offering up to several thousand dollars in compensation for participation.

Conditions:

Healthy

Healthy Volunteer Study

Learn More

* Compensation for time may be available

Featured Trial

Heart Failure Clinical Trial

Recruiting

You or someone you love may be eligible for a heart failure clinical study. Eligible participants will receive study-related assessments, care, and treatment at no cost. You may be reimbursed for travel while participating. See if you are eligible.

Conditions:

Heart Failure

Congestive Heart Failure

Chronic Heart Failure

Heart Failure

Congestive

Learn More

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Recruiting

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Conditions:

Overweight

Overweight and Obesity

Obesity

Weight Loss

Morbid Obesity

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The Impact of an Adaptive Patient-centered Web Application on Medication Optimization in HFrEF Patients

NCT05858320

Recruiting

The SmartHF study is a 12-week prospective randomized controlled multicenter clinical trial. This study will investigate the efficacy of an adaptive web application to facilitate guideline-directed medical therapy (GDMT) optimization in HFrEF patients. Eligible participants will be randomized to the web application intervention or control in a 1:1 manner, stratified by site. The intervention is an adaptive medication optimization web application that extracts and analyzes the EHR data with a co... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/02/2025

Locations: Emory University, Grady Hospital, Atlanta, Georgia +4 locations

Conditions: Heart Failure

Learn More ›

Assessment of CCM in HF With Higher Ejection Fraction

NCT05064709

Recruiting

The AIM HIGHer Clinical Trial will evaluate the safety and efficacy of Cardiac Contractility Modulation (CCM) therapy in patients with heart failure with LVEF ≥40% and ≤70%.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/02/2025

Locations: Grandview Medical Group Research, LLC, Birmingham, Alabama +103 locations

Grandview Medical Group Research, LLC, Birmingham, Alabama

The University of Alabama at Birmingham, Birmingham, Alabama

CardioVascular Associates of Mesa, Mesa, Arizona

Chan Heart Rhythm Institute, Mesa, Arizona

Southwest Cardiovascular Associates, Mesa, Arizona

Banner Health- Phoenix, Phoenix, Arizona

Arizona Heart Rhythm, Phoenix, Arizona

Cardiovascular Consultants, Ltd, Phoenix, Arizona

HonorHealth, Scottsdale, Arizona

Pima Heart and Vascular, Tuscon, Arizona

John Muir Health, Concord, California

Northbay Heart and Vascular, Fairfield, California

University of California San Diego, La Jolla, California

USC Keck School of Medicine, Los Angeles, California

Cedars Sinai Medical Center, Los Angeles, California

Valley Clinical Trials Pasadena, Northridge, California

Valley Clinical Trials- Northridge, Northridge, California

Sequoia Hospital, Redwood City, California

University of California Davis Health, Sacramento, California

University of California, San Francisco, San Francisco, California

Hartford Healthcare, Hartford, Connecticut

Nuvance Health, Wilton, Connecticut

HCA Florida JFK Hospital, Atlantis, Florida

Nouvelle Clinical Research LLC, Cutler Bay, Florida

Holy Cross Hospital, Fort Lauderdale, Florida

Broward Health, Fort Lauderdale, Florida

Memorial Healthcare System, Hollywood, Florida

Baptist Health South Florida, Miami, Florida

NCA Research Institute - Florida, Naples, Florida

AdventHealth Orlando, Orlando, Florida

Revival Clinical Research, Orlando, Florida

Tallahassee Research Institute, Tallahassee, Florida

Cleveland Clinic Foundation - Florida Weston Hospital, Weston, Florida

Piedmont Healthcare, Atlanta, Georgia

WellStar Health System, Inc, Marietta, Georgia

Franciscan Health Indianapolis, Indianapolis, Indiana

Ascension Medical Group St. Vincent, Indianapolis, Indiana

University of Iowa, Iowa City, Iowa

MercyOne Iowa Heart, West Des Moines, Iowa

University of Kansas Medical Center, Kansas City, Kansas

Kansas City Cardiac Arrhythmia Research LLC, Overland Park, Kansas

Baptist Health Lexington, Lexington, Kentucky

University of Kentucky Research Foundation, Lexington, Kentucky

Ochsner Clinic Foundation, New Orleans, Louisiana

Massachusetts General Hospital, Boston, Massachusetts

Ascension St. John, Detroit, Michigan

Ascension Providence Hospital, Southfield, Michigan

Trinity health- Michigan Heart, Ypsilanti, Michigan

Minneapolis Heart Institute at Abbott Northwestern Hospital, Minneapolis, Minnesota

North Mississippi Medical Center, Tupelo, Mississippi

St. Louis Heart and Vascular, Bridgeton, Missouri

St. Luke's Hospital, Chesterfield, Missouri

St. Lukes Hospital Kansas City (Mid America Heart Institute), Kansas City, Missouri

Bryan Heart, Lincoln, Nebraska

University of Nebraska Medical Center, Omaha, Nebraska

Catholic Medical Center, Manchester, New Hampshire

Our Lady of Lourdes, Camden, New Jersey

Hackensack University Medical Center, Edison, New Jersey

Jersey Shore University Medical Center, Edison, New Jersey

Cooper Hospital- Cardiovascular Associates of Delaware Valley, Haddon Heights, New Jersey

Atlantic Health System- Morristown Medical Center, Morristown, New Jersey

Rutgers New Jersey Medical School, Piscataway, New Jersey

Weill Cornell Medicine, New York, New York

Sanger Heart and Vascular, Charlotte, North Carolina

TriHealth Bethesda, Cincinnati, Ohio

University Hospitals Cleveland Medical Center, Cleveland, Ohio

Cleveland Clinic Foundation, Cleveland, Ohio

Ohio State University Wexner Medical Center, Columbus, Ohio

OhioHealth Research Institute, Columbus, Ohio

Mercy Health- St. Vincent Medical Center LLC, Toledo, Ohio

Oklahoma Heart Institute, Tulsa, Oklahoma

St. Francis Hospital - Tulsa, Tulsa, Oklahoma

Providence Heart & Vascular, Portland, Oregon

Bryn Mawr Medical Specialists Association, Bryn Mawr, Pennsylvania

UPMC Pinnacle Harrisburg, Harrisburg, Pennsylvania

Penn State Hershey Medical City, Hershey, Pennsylvania

Lancaster General Hospital, Lancaster, Pennsylvania

Penn Presbyterian Medical Center, Philadelphia, Pennsylvania

Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania

Thomas Jefferson University Hospital, Philadelphia, Pennsylvania

Temple University Hospital, Philadelphia, Pennsylvania

Allegheny General Hospital, Pittsburgh, Pennsylvania

University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania

Tower Health Reading Hospital, Reading, Pennsylvania

WellSpan Health, York, Pennsylvania

Prisma Health Upstate, Greenville, South Carolina

Bon Secours Upstate Cardiology, Greenville, South Carolina

The Stern Cardiovascular Foundation, Germantown, Tennessee

Texas Cardiac Arrhythmia Research Foundation, Austin, Texas

Ascension Seton, Austin, Texas

Austin Heart, Austin, Texas

Baylor Scott and White Research Institute, Dallas, Texas

HCA Medical City Dallas, Dallas, Texas

Baylor Scott White- All Saints- Fort Worth, Fort Worth, Texas

Medical City Fort Worth Hospital, Fort Worth, Texas

Baylor College of Medicine, Houston, Texas

Houston Methodist, Houston, Texas

Memorial Hermann Texas Medical Center, Houston, Texas

Heart Rhythm Specialists, McKinney, Texas

Baylor Scott and White- The Heart Hospital- Plano, Plano, Texas

Baylor Scott and White Research Institute - Round Rock, Round Rock, Texas

Methodist Hospital, San Antonio, Texas

Swedish Medical Center, Seattle, Washington

Peace Health, Vancouver, Washington

Conditions: Heart Failure, Heart Failure With Preserved Ejection Fraction, Heart Failure With Mid Range Ejection Fraction, Heart Failure With Moderately Reduced Ejection Fraction, Diastolic Heart Failure

Learn More ›

Donor Bone Marrow Derived Mesenchymal Stem Cells in Controlling Heart Failure in Patients With Cardiomyopathy Caused by Anthracyclines

NCT02962661

Recruiting

This randomized pilot phase I trial studies the side effects of donor bone marrow derived mesenchymal stem cells in controlling heart failure in patients with cardiomyopathy caused by anthracyclines. Donor bone marrow derived mesenchymal stem cells may help to control symptoms of heart failure and improve heart function.

Gender:

ALL

Ages:

Between 18 years and 80 years

Trial Updated:

06/01/2025

Locations: M D Anderson Cancer Center, Houston, Texas

Conditions: Cardiomyopathy, Heart Failure, Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm

Learn More ›

Heart Failure Precision Medicine Study

NCT04196842

Recruiting

The study aims to test the hypothesis that multi-omics studies can identify Heart Failure profiles at risk of adverse outcomes and evaluate a telemonitoring intervention in the optimization of guideline-directed medical therapy.

Gender:

ALL

Ages:

21 years and above

Trial Updated:

05/31/2025

Locations: UC Davis Medical Center, Sacramento, California

Conditions: Heart Failure

Learn More ›

Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products

NCT00271180

Recruiting

The main purpose of the Product Performance Report (formerly referred to as System Longevity Study) is to evaluate long-term performance of Medtronic market-released cardiac rhythm products by analyzing product survival probabilities.

Gender:

ALL

Ages:

All

Trial Updated:

05/30/2025

Locations: Not set, Birmingham, Alabama +311 locations

Not set, Birmingham, Alabama

Not set, Anchorage, Alaska

Not set, Chandler, Arizona

Not set, Jonesboro, Arkansas

Not set, Little Rock, Arkansas

Not set, Bakersfield, California

Not set, Chula Vista, California

Not set, La Jolla, California

Not set, Los Angeles, California

Not set, Palm Springs, California

Not set, Rancho Mirage, California

Not set, Redwood City, California

Not set, Salinas, California

Not set, San Diego, California

Not set, Stanford, California

Not set, Torrance, California

Not set, Van Nuys, California

Not set, Ventura, California

Not set, Aurora, Colorado

Not set, Centennial, Colorado

Not set, Colorado Springs, Colorado

Not set, Denver, Colorado

Not set, Lakewood, Colorado

Not set, Hartford, Connecticut

Not set, New Haven, Connecticut

Not set, Washington, District of Columbia

Not set, Bradenton, Florida

Not set, Clearwater, Florida

Not set, Hollywood, Florida

Not set, Jacksonville, Florida

Not set, Panama City, Florida

Not set, Safety Harbor, Florida

Not set, Sarasota, Florida

Not set, Atlanta, Georgia

Not set, Marietta, Georgia

Not set, Evansville, Indiana

Not set, Indianapolis, Indiana

Not set, West Des Moines, Iowa

Not set, Kansas City, Kansas

Not set, Edgewood, Kentucky

Not set, Louisville, Kentucky

Not set, Baton Rouge, Louisiana

Not set, Shreveport, Louisiana

Not set, Baltimore, Maryland

Not set, Bethesda, Maryland

Not set, Clinton, Maryland

Not set, Hyattsville, Maryland

Not set, Salisbury, Maryland

Not set, Silver Spring, Maryland

Not set, Takoma Park, Maryland

Not set, Boston, Massachusetts

Not set, Lansing, Michigan

Not set, Marquette, Michigan

Not set, Ypsilanti, Michigan

Not set, Coon Rapids, Minnesota

Not set, Minneapolis, Minnesota

Not set, Robbinsdale, Minnesota

Not set, Rochester, Minnesota

Not set, Saint Cloud, Minnesota

Not set, Saint Paul, Minnesota

Not set, Hattiesburg, Mississippi

Not set, Columbia, Missouri

Not set, Kansas City, Missouri

Not set, Saint Louis, Missouri

Not set, Omaha, Nebraska

Not set, Marlton, New Jersey

Not set, Morristown, New Jersey

Not set, New Brunswick, New Jersey

Not set, Ocean, New Jersey

Not set, Ridgewood, New Jersey

Not set, Albuquerque, New Mexico

Not set, Huntington, New York

Not set, Manhasset, New York

Not set, New York, New York

Not set, Poughkeepsie, New York

Not set, Utica, New York

Not set, Durham, North Carolina

Not set, Raleigh, North Carolina

Not set, Akron, Ohio

Not set, Cincinnati, Ohio

Not set, Cleveland, Ohio

Not set, Columbus, Ohio

Not set, Toledo, Ohio

Not set, Oklahoma City, Oklahoma

Not set, Portland, Oregon

Not set, Allentown, Pennsylvania

Not set, Bethlehem, Pennsylvania

Not set, Danville, Pennsylvania

Not set, Erie, Pennsylvania

Not set, Lancaster, Pennsylvania

Not set, Philadelphia, Pennsylvania

Not set, Pittsburgh, Pennsylvania

Not set, Wilkes-Barre, Pennsylvania

Not set, Columbia, South Carolina

Not set, Germantown, Tennessee

Not set, Nashville, Tennessee

Not set, Austin, Texas

Not set, Dallas, Texas

Not set, Fort Worth, Texas

Not set, Houston, Texas

Not set, Plano, Texas

Not set, The Woodlands, Texas

Not set, Tyler, Texas

Not set, Burlington, Vermont

Not set, Charlottesville, Virginia

Not set, Olympia, Washington

Not set, Spokane, Washington

Not set, Madison, Wisconsin

Not set, Milwaukee, Wisconsin

Not set, Chermside, Not set

Not set, Douglas, Not set

Not set, Murdoch, Not set

Not set, Southport, Not set

Not set, Graz, Not set

Not set, Innsbruck, Not set

Not set, Linz, Not set

Not set, Wien, Not set

Not set, Brugge, Not set

Not set, Brussel, Not set

Not set, Edegem, Not set

Not set, Leuven, Not set

Not set, Liège, Not set

Not set, Yvoir, Not set

Not set, Calgary, Not set

Not set, Kingston, Not set

Not set, Montreal, Not set

Not set, Québec, Not set

Not set, Beijing, Not set

Not set, Changsha, Not set

Not set, Dalian, Not set

Not set, Fuzhou, Not set

Not set, Guangzhou, Not set

Not set, Hangzhou, Not set

Not set, Harbin, Not set

Not set, Kunming, Not set

Not set, Nanchang, Not set

Not set, Shanghai, Not set

Not set, Shantou, Not set

Not set, Suzhou, Not set

Not set, Taiyuan, Not set

Not set, Tianjin, Not set

Not set, Praha, Not set

Not set, Copenhagen, Not set

Not set, Hellerup, Not set

Not set, Hillerød, Not set

Not set, Odense, Not set

Not set, Århus, Not set

Not set, Helsinki, Not set

Not set, Avignon, Not set

Not set, Bayonne, Not set

Not set, Brest, Not set

Not set, Caen, Not set

Not set, Chambray-lès-Tours, Not set

Not set, Clermont-Ferrand, Not set

Not set, Dijon, Not set

Not set, La Rochelle, Not set

Not set, La Tronche, Not set

Not set, Lille, Not set

Not set, Montpellier, Not set

Not set, Nantes, Not set

Not set, Neuilly-sur-Seine, Not set

Not set, Paris, Not set

Not set, Pessac, Not set

Not set, Pringy, Not set

Not set, Rennes, Not set

Not set, Saint-Priest-en-Jarez, Not set

Not set, Strasbourg, Not set

Not set, Toulouse, Not set

Not set, Vandoeuvre les Nancy, Not set

Not set, Villeurbanne, Not set

Not set, Aachen, Not set

Not set, Bad Oeynhausen, Not set

Not set, Bremen, Not set

Not set, Dresden, Not set

Not set, Düsseldorf, Not set

Not set, Essen, Not set

Not set, Hamburg, Not set

Not set, Hannover, Not set

Not set, Heidelberg, Not set

Not set, Homburg, Not set

Not set, Jena, Not set

Not set, Köln, Not set

Not set, München, Not set

Not set, Münster, Not set

Not set, Tübingen, Not set

Not set, Ulm, Not set

Not set, Villingen-Schwenningen, Not set

Not set, Athens, Not set

Not set, Marousi, Not set

Not set, Thessaloníki, Not set

Not set, Hong Kong, Not set

Not set, Budapest, Not set

Not set, Reykjavik, Not set

Not set, Bangalore, Not set

Not set, Gurgaon, Not set

Not set, New Delhi, Not set

Not set, Ashkelon, Not set

Not set, Be'er Sheva, Not set

Not set, Jerusalem, Not set

Not set, Ramat Gan, Not set

Not set, Ancona, Not set

Not set, Bari, Not set

Not set, Bologna, Not set

Not set, Brescia, Not set

Not set, Castrovillari, Not set

Not set, Cotignola, Not set

Not set, Lecce, Not set

Not set, Milano, Not set

Not set, Monza, Not set

Not set, Pisa, Not set

Not set, Taranto, Not set

Not set, Udine, Not set

Not set, Ageo, Not set

Not set, Gifu, Not set

Not set, Hidaka, Not set

Not set, Hiroshima City, Not set

Not set, Kagoshima, Not set

Not set, Kamakura, Not set

Not set, Kawasaki, Not set

Not set, Kitakyushu, Not set

Not set, Koshigaya, Not set

Not set, Kumamoto, Not set

Not set, Kyoto, Not set

Not set, Mitaka, Not set

Not set, Nagoya, Not set

Not set, Niigata, Not set

Not set, Okayama, Not set

Not set, Sapporo, Not set

Not set, Shinagawa-Ku, Not set

Not set, Shizuoka, Not set

Not set, Suita, Not set

Not set, Tokyo, Not set

Not set, Toyoake, Not set

Not set, Urasoe, Not set

Not set, Yamagata, Not set

Not set, Yokohama, Not set

Not set, Ōsaka-sayama, Not set

Not set, Cheongju-si, Not set

Not set, Daejeon, Not set

Not set, Gyeonggi-do, Not set

Not set, Seoul, Not set

Not set, Suwon-si, Not set

Not set, Hadiya, Not set

Not set, Kuwait, Not set

Not set, Kuala Lumpur, Not set

Not set, Amsterdam, Not set

Not set, Breda, Not set

Not set, Den Haag, Not set

Not set, Eindhoven, Not set

Not set, Enschede, Not set

Not set, Groningen, Not set

Not set, Leiden, Not set

Not set, Maastricht, Not set

Not set, Nieuwegein, Not set

Not set, Rotterdam, Not set

Not set, Christchurch, Not set

Not set, Bergen, Not set

Not set, Oslo, Not set

Not set, Trondheim, Not set

Not set, Poznań, Not set

Not set, Warsaw, Not set

Not set, Zabrze, Not set

Not set, Carnaxide, Not set

Not set, Creixomil, Not set

Not set, Lisboa, Not set

Not set, Porto, Not set

Not set, Santarém, Not set

Not set, Jeddah, Not set

Not set, Riyadh, Not set

Not set, Belgrade, Not set

Not set, Bratislava, Not set

Not set, Košice, Not set

Not set, Ljubljana, Not set

Not set, A Coruña, Not set

Not set, Barcelona, Not set

Not set, Córdoba, Not set

Not set, Girona, Not set

Not set, Granada, Not set

Not set, Madrid, Not set

Not set, Palma De Mallorca, Not set

Not set, Salamanca, Not set

Not set, Santa Cruz De Tenerife, Not set

Not set, Santiago de Compostela, Not set

Not set, Toledo, Not set

Not set, Valencia, Not set

Not set, Valladolid, Not set

Not set, Vitoria-Gasteiz, Not set

Not set, Göteborg, Not set

Not set, Lund, Not set

Not set, Skövde, Not set

Not set, Uppsala, Not set

Not set, Basel, Not set

Not set, Bern, Not set

Not set, Fribourg, Not set

Not set, Geneva, Not set

Not set, Lausanne, Not set

Not set, Lugano, Not set

Not set, Zürich, Not set

Not set, Birmingham, Not set

Not set, Blackpool, Not set

Not set, Bristol, Not set

Not set, Leeds, Not set

Not set, Leicester, Not set

Not set, Liverpool, Not set

Not set, London, Not set

Not set, Manchester, Not set

Not set, Middlesbrough, Not set

Not set, Northampton, Not set

Not set, Nottingham, Not set

Not set, Sheffield, Not set

Not set, Southampton, Not set

Conditions: Arrhythmia, Bradycardia, Heart Failure, Sinus Tachycardia

Learn More ›

Staged Kidney Transplantation During Combined Heart/Kidney Transplantation

NCT06877169

Recruiting

The primary purpose of this study is to evaluate the safety and efficacy of ex vivo machine perfusion with staged implantation of kidney allografts during combined heart/kidney transplantation.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

05/29/2025

Locations: Cedars-Sinai Medical Center, Los Angeles, California

Conditions: Heart Failure, Chronic Kidney Disease, End-stage Kidney Disease

Learn More ›

Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin

NCT06677060

Recruiting

Participants include men and women ≥ 40 years of age with T2DM, established CV disease, a history of HTN with an SBP of at least 130 mmHg at screening, who meet the predefined serum potassium level, and with at least one additional risk factor for HF. The study will include an optional pre-screening period to facilitate sites' identification of potentially eligible participants to enter the full screening assessments. Participants will not be required to visit the site and no informed consent i... Read More

Gender:

ALL

Ages:

40 years and above

Trial Updated:

05/29/2025

Locations: Research Site, Birmingham, Alabama +806 locations

Research Site, Birmingham, Alabama

Research Site, Centreville, Alabama

Research Site, Fairhope, Alabama

Research Site, Mobile, Alabama

Research Site, Vestavia Hills, Alabama

Research Site, Glendale, Arizona

Research Site, Dublin, California

Research Site, Huntington Beach, California

Research Site, Inglewood, California

Research Site, Lakewood, California

Research Site, Lincoln, California

Research Site, Loma Linda, California

Research Site, San Diego, California

Research Site, San Dimas, California

Research Site, San Francisco, California

Research Site, Thousand Oaks, California

Research Site, Englewood, Colorado

Research Site, Waterbury, Connecticut

Research Site, Crystal River, Florida

Research Site, Fort Lauderdale, Florida

Research Site, Fort Myers, Florida

Research Site, Gainesville, Florida

Research Site, Hialeah, Florida

Research Site, Jacksonville, Florida

Research Site, Lakeland, Florida

Research Site, Miami, Florida

Research Site, Palmetto Bay, Florida

Research Site, Saint Augustine, Florida

Research Site, Atlanta, Georgia

Research Site, Canton, Georgia

Research Site, Columbus, Georgia

Research Site, Suwanee, Georgia

Research Site, Woodstock, Georgia

Research Site, Chicago, Illinois

Research Site, Indianapolis, Indiana

Research Site, Munster, Indiana

Research Site, South Bend, Indiana

Research Site, El Dorado, Kansas

Research Site, Lenexa, Kansas

Research Site, Wichita, Kansas

Research Site, Paducah, Kentucky

Research Site, Baltimore, Maryland

Research Site, Beltsville, Maryland

Research Site, Potomac, Maryland

Research Site, New Bedford, Massachusetts

Research Site, Roslindale, Massachusetts

Research Site, Troy, Michigan

Research Site, Mankato, Minnesota

Research Site, Columbia, Missouri

Research Site, Saint Louis, Missouri

Research Site, Missoula, Montana

Research Site, Norfolk, Nebraska

Research Site, Omaha, Nebraska

Research Site, Portsmouth, New Hampshire

Research Site, Albuquerque, New Mexico

Research Site, Brooklyn, New York

Research Site, Massapequa, New York

Research Site, Charlotte, North Carolina

Research Site, Durham, North Carolina

Research Site, Monroe, North Carolina

Research Site, New Bern, North Carolina

Research Site, Raleigh, North Carolina

Research Site, Beavercreek, Ohio

Research Site, Cincinnati, Ohio

Research Site, Columbus, Ohio

Research Site, Norman, Oklahoma

Research Site, Grants Pass, Oregon

Research Site, Medford, Oregon

Research Site, Horsham, Pennsylvania

Research Site, Greenville, South Carolina

Research Site, Mount Pleasant, South Carolina

Research Site, North Charleston, South Carolina

Research Site, Morristown, Tennessee

Research Site, Nashville, Tennessee

Research Site, Abilene, Texas

Research Site, Austin, Texas

Research Site, Beaumont, Texas

Research Site, El Paso, Texas

Research Site, Mesquite, Texas

Research Site, Paris, Texas

Research Site, Pearland, Texas

Research Site, Sugar Land, Texas

Research Site, Woodway, Texas

Research Site, Roy, Utah

Research Site, Burke, Virginia

Research Site, Charlottesville, Virginia

Research Site, Falls Church, Virginia

Research Site, Richmond, Virginia

Research Site, Salem, Virginia

Research Site, Buenos Aires, Not set

Research Site, Caba, Not set

Research Site, Cordoba, Not set

Research Site, Córdoba, Not set

Research Site, La Plata, Not set

Research Site, Mar del Plata, Not set

Research Site, Rosario, Not set

Research Site, San Nicolas de los Arroyos, Not set

Research Site, San Nicolás, Not set

Research Site, San Vicente, Not set

Research Site, Santa Fe, Not set

Research Site, Adelaide, Not set

Research Site, Elizabeth Vale, Not set

Research Site, Fremantle, Not set

Research Site, Geelong, Not set

Research Site, Kingswood, Not set

Research Site, Leabrook, Not set

Research Site, Maroubra, Not set

Research Site, Merewether, Not set

Research Site, Milton, Not set

Research Site, Mulgrave, Not set

Research Site, Osborne Park, Not set

Research Site, Rockhampton, Not set

Research Site, Wollongong, Not set

Research Site, Belem, Not set

Research Site, Blumenau, Not set

Research Site, Bragança Paulista, Not set

Research Site, Brasilia, Not set

Research Site, Campina Grande do Sul, Not set

Research Site, Campinas, Not set

Research Site, Curitiba, Not set

Research Site, Juiz de Fora, Not set

Research Site, Natal, Not set

Research Site, Porto Alegre, Not set

Research Site, Rio de Janeiro, Not set

Research Site, Sao Jose Do Rio Preto, Not set

Research Site, Sao Jose dos Campos, Not set

Research Site, Sao Paulo, Not set

Research Site, São Paulo, Not set

Research Site, Tatuí, Not set

Research Site, Haskovo, Not set

Research Site, Panagyurishte, Not set

Research Site, Petrich, Not set

Research Site, Pleven, Not set

Research Site, Plovdiv, Not set

Research Site, Russe, Not set

Research Site, Shumen, Not set

Research Site, Sofia, Not set

Research Site, Varna, Not set

Research Site, Calgary, Alberta

Research Site, Sherwood Park, Alberta

Research Site, Surrey, British Columbia

Research Site, Moncton, New Brunswick

Research Site, St. John, New Brunswick

Research Site, St. John's, Newfoundland and Labrador

Research Site, Halifax, Nova Scotia

Research Site, Sydney, Nova Scotia

Research Site, Cambridge, Ontario

Research Site, Guelph, Ontario

Research Site, Hamilton, Ontario

Research Site, Markham, Ontario

Research Site, Newmarket, Ontario

Research Site, North York, Ontario

Research Site, Oakville, Ontario

Research Site, Ottawa, Ontario

Research Site, Sarnia, Ontario

Research Site, Toronto, Ontario

Research Site, Laval, Quebec

Research Site, Levis, Quebec

Research Site, Mirabel, Quebec

Research Site, Montreal, Quebec

Research Site, Saint-Charles-Borromee, Quebec

Research Site, Sherbrooke, Quebec

Research Site, Terrebonne, Quebec

Research Site, Trois-Rivières, Quebec

Research Site, Regina, Saskatchewan

Research Site, Quebec, Not set

Research Site, Baotou, Not set

Research Site, Beijing, Not set

Research Site, Changchun, Not set

Research Site, Changde, Not set

Research Site, Changsha, Not set

Research Site, Changzhou, Not set

Research Site, Chengdu, Not set

Research Site, Chifeng, Not set

Research Site, Chongqing, Not set

Research Site, Guangzhou, Not set

Research Site, Harbin, Not set

Research Site, Hengyang, Not set

Research Site, Heze, Not set

Research Site, Huangshi, Not set

Research Site, Huizhou, Not set

Research Site, Jinan, Not set

Research Site, Jining, Not set

Research Site, Kaifeng, Not set

Research Site, Liaocheng, Not set

Research Site, Linhai, Not set

Research Site, Linyi, Not set

Research Site, Lishui, Not set

Research Site, Luoyang, Not set

Research Site, Meihekou, Not set

Research Site, Nanchang, Not set

Research Site, Nanjing, Not set

Research Site, Nantong, Not set

Research Site, Nanyang, Not set

Research Site, Panjin, Not set

Research Site, Pingxiang, Not set

Research Site, Sanya, Not set

Research Site, Shanghai, Not set

Research Site, Shenyang, Not set

Research Site, Siping, Not set

Research Site, Suzhou, Not set

Research Site, Taiyuan, Not set

Research Site, Tianjin, Not set

Research Site, Wenzhou, Not set

Research Site, Wuhan, Not set

Research Site, Xi'an, Not set

Research Site, Xianyang, Not set

Research Site, Xuzhou, Not set

Research Site, Yinchuan, Not set

Research Site, Zhumadian, Not set

Research Site, Zigong, Not set

Research Site, Benesov, Not set

Research Site, Brandys nad Labem, Not set

Research Site, Brno, Not set

Research Site, Broumov, Not set

Research Site, Chlumec nad Cidlinou, Not set

Research Site, Hodonin, Not set

Research Site, Humpolec, Not set

Research Site, Jílové u Prahy, Not set

Research Site, Krnov, Not set

Research Site, Olomouc, Not set

Research Site, Ostrava, Not set

Research Site, Plzeň, Not set

Research Site, Police nad Metují, Not set

Research Site, Prague, Not set

Research Site, Praha 10, Not set

Research Site, Praha 2, Not set

Research Site, Praha 4, Not set

Research Site, Praha, Not set

Research Site, Aalborg, Not set

Research Site, Aarhus N, Not set

Research Site, Aarhus, Not set

Research Site, Esbjerg, Not set

Research Site, Frederiksberg, Not set

Research Site, Gistrup, Not set

Research Site, Herlev, Not set

Research Site, Herning, Not set

Research Site, Hillerød, Not set

Research Site, Hjørring, Not set

Research Site, Holbæk, Not set

Research Site, Hvidovre, Not set

Research Site, København, Not set

Research Site, Roskilde, Not set

Research Site, Slagelse, Not set

Research Site, Svendborg, Not set

Research Site, Viborg, Not set

Research Site, Amiens, Not set

Research Site, Angers, Not set

Research Site, Aurillac Cedex, Not set

Research Site, Besançon Cedex, Not set

Research Site, Bobigny, Not set

Research Site, Bois-Guillaume, Not set

Research Site, Brest Cedex, Not set

Research Site, Caen, Not set

Research Site, Cholet, Not set

Research Site, Clermont-Ferrand, Not set

Research Site, Colombes, Not set

Research Site, Corbeil Essonnes Cedex, Not set

Research Site, Dijon, Not set

Research Site, La Roche Sur Yon Cedex 9, Not set

Research Site, La Rochelle, Not set

Research Site, Le Coudray, Not set

Research Site, Le Creusot, Not set

Research Site, Lyon, Not set

Research Site, Marseille, Not set

Research Site, Montpellier Cedex 5, Not set

Research Site, Nantes Cedex 1, Not set

Research Site, Narbonne CEDEX, Not set

Research Site, PARIS Cedex 15, Not set

Research Site, Paris, Not set

Research Site, Pierre Benite, Not set

Research Site, TOULOUSE Cedex 9, Not set

Research Site, Vandoeuvre les Nancy Cedex, Not set

Research Site, Villeurbanne, Not set

Research Site, Aachen, Not set

Research Site, Amberg, Not set

Research Site, Bad Homburg, Not set

Research Site, Bad Oeynhausen, Not set

Research Site, Bamberg, Not set

Research Site, Bechhofen, Not set

Research Site, Berlin, Not set

Research Site, Bochum, Not set

Research Site, Bremen, Not set

Research Site, Deggingen, Not set

Research Site, Dresden, Not set

Research Site, Elsterwerda, Not set

Research Site, Essen, Not set

Research Site, Frankfurt, Not set

Research Site, Freiburg, Not set

Research Site, Friedrichsthal, Not set

Research Site, Fulda, Not set

Research Site, Gelnhausen, Not set

Research Site, Görlitz, Not set

Research Site, Hamburg, Not set

Research Site, Haßloch, Not set

Research Site, Heidelberg, Not set

Research Site, Homburg, Not set

Research Site, Kaiserslautern, Not set

Research Site, Kassel, Not set

Research Site, Köln, Not set

Research Site, Langen, Not set

Research Site, Leipzig, Not set

Research Site, Ludwigshafen, Not set

Research Site, Markkleeberg, Not set

Research Site, Munich, Not set

Research Site, Münster, Not set

Research Site, Naunhof, Not set

Research Site, Neuruppin, Not set

Research Site, Nittendorf, Not set

Research Site, Obertshausen, Not set

Research Site, Oldenburg, Not set

Research Site, Osnabrück, Not set

Research Site, Papenburg, Not set

Research Site, Pirna, Not set

Research Site, Potsdam, Not set

Research Site, Reinfeld (Holstein), Not set

Research Site, Völklingen, Not set

Research Site, Wallerfing, Not set

Research Site, Wangen, Not set

Research Site, Weinheim, Not set

Research Site, Zwenkau, Not set

Research Site, Athens, Not set

Research Site, Chania, Not set

Research Site, Ioannina, Not set

Research Site, Larissa, Not set

Research Site, Piraeus, Not set

Research Site, Thessaloniki, Not set

Research Site, Balatonfüred, Not set

Research Site, Budapest, Not set

Research Site, Békéscsaba, Not set

Research Site, Debrecen, Not set

Research Site, Gyöngyös, Not set

Research Site, Kalocsa, Not set

Research Site, Nyíregyháza-Sóstóhegy, Not set

Research Site, Nyíregyháza, Not set

Research Site, Orosháza, Not set

Research Site, Pécs, Not set

Research Site, Szeged, Not set

Research Site, Szigetvár, Not set

Research Site, Szolnok, Not set

Research Site, Székesfehérvár, Not set

Research Site, Ahmedabad, Not set

Research Site, Ajmer, Not set

Research Site, Bangalore, Not set

Research Site, Belagavi, Not set

Research Site, Delhi, Not set

Research Site, Gurgaon, Not set

Research Site, Hyderabad, Not set

Research Site, Karamsad, Not set

Research Site, Kolkata, Not set

Research Site, Lucknow, Not set

Research Site, Nagpur, Not set

Research Site, New Delhi, Not set

Research Site, Surat, Not set

Research Site, Vijayawada, Not set

Research Site, Beer Sheba, Not set

Research Site, Haifa, Not set

Research Site, Herzelia, Not set

Research Site, Holon, Not set

Research Site, Jerusalem, Not set

Research Site, Petah Tikva, Not set

Research Site, Ramat Gan, Not set

Research Site, Tel Aviv, Not set

Research Site, Tel-Aviv, Not set

Research Site, Alessandria, Not set

Research Site, Bari, Not set

Research Site, Bergamo, Not set

Research Site, Brescia, Not set

Research Site, Chiavari, Not set

Research Site, Cona, Not set

Research Site, Foggia, Not set

Research Site, Milano, Not set

Research Site, Milan, Not set

Research Site, Mondovi, Not set

Research Site, Monza, Not set

Research Site, Napoli, Not set

Research Site, Novara, Not set

Research Site, Orbassano, Not set

Research Site, Palermo, Not set

Research Site, Pavia, Not set

Research Site, Potenza, Not set

Research Site, Roma, Not set

Research Site, Rome, Not set

Research Site, Rozzano, Not set

Research Site, Siena, Not set

Research Site, Torino, Not set

Research Site, Udine, Not set

Research Site, Aizu Wakamatsu-shi, Not set

Research Site, Amagasaki-shi, Not set

Research Site, Asahikawa-shi, Not set

Research Site, Azumino-shi, Not set

Research Site, Hakusan-shi, Not set

Research Site, Himeji, Not set

Research Site, Itabashi-ku, Not set

Research Site, Itabashi, Not set

Research Site, Izumo-shi, Not set

Research Site, Kakegawa-shi, Not set

Research Site, Kamakura-shi, Not set

Research Site, Kanazawa-shi, Not set

Research Site, Kawaguchi-shi, Not set

Research Site, Kishiwada-shi, Not set

Research Site, Kita-ku, Not set

Research Site, Kyoto-shi, Not set

Research Site, Matsudo-shi, Not set

Research Site, Meguro-ku, Not set

Research Site, Mito-shi, Not set

Research Site, Miyazaki-shi, Not set

Research Site, Nagano, Not set

Research Site, Ogaki-shi, Not set

Research Site, Oita-shi, Not set

Research Site, Osaka-shi, Not set

Research Site, Osaka, Not set

Research Site, Saitama-shi, Not set

Research Site, Sapporo-shi, Not set

Research Site, Sendai-shi, Not set

Research Site, Shizuoka-shi, Not set

Research Site, Takamatsu-shi, Not set

Research Site, Toyota-Shi, Not set

Research Site, Tsuchiura-shi, Not set

Research Site, Ueda-shi, Not set

Research Site, Uwajima-shi, Not set

Research Site, Yanagawa-shi, Not set

Research Site, Yokkaichi-shi, Not set

Research Site, Yokohama-shi, Not set

Research Site, Bucheon-si, Not set

Research Site, Cheongju-si, Not set

Research Site, Daegu, Not set

Research Site, Seongnam-si, Not set

Research Site, Seoul, Not set

Research Site, Suwon-si, Not set

Research Site, Wonju-si, Not set

Research Site, Yangsan-si, Not set

Research Site, Alor Setar, Not set

Research Site, Johor Bahru, Not set

Research Site, Kota Samarahan, Not set

Research Site, Kuantan, Not set

Research Site, Kuching, Not set

Research Site, Malacca, Not set

Research Site, Rawang, Not set

Research Site, Sarawak Miri, Not set

Research Site, Seri Manjung, Not set

Research Site, Sungai Buloh, Not set

Research Site, Acapulco, Not set

Research Site, Aguascalientes, Not set

Research Site, Ciudad de México, Not set

Research Site, Cuauhtemoc, Not set

Research Site, Cuernavaca, Not set

Research Site, Culiacan, Not set

Research Site, Culiacán, Not set

Research Site, Durango, Not set

Research Site, Guadalajara, Not set

Research Site, Monterey, Not set

Research Site, San Juan del Rio, Not set

Research Site, Santiago de Querétaro, Not set

Research Site, Veracruz, Not set

Research Site, Xalapa, Not set

Research Site, Zapopan, Not set

Research Site, Amsterdam, Not set

Research Site, Beek, Not set

Research Site, Den Bosch, Not set

Research Site, Deventer, Not set

Research Site, Ede, Not set

Research Site, Enschede, Not set

Research Site, Groningen, Not set

Research Site, Haarlem, Not set

Research Site, Harderwijk, Not set

Research Site, Hengelo, Not set

Research Site, Hoogeveen, Not set

Research Site, Nijmegen, Not set

Research Site, Roosendaal, Not set

Research Site, Rotterdam, Not set

Research Site, Venlo, Not set

Research Site, Zwolle, Not set

Research Site, Bellavista, Not set

Research Site, Chorrillos, Not set

Research Site, Lima, Not set

Research Site, LIma, Not set

Research Site, Lima, Not set

Research Site, Piura, Not set

Research Site, Angeles City, Not set

Research Site, Cebu, Not set

Research Site, Davao City, Not set

Research Site, Fuente Osmena Cebu City, Not set

Research Site, Iloilo City, Not set

Research Site, Las Pinas, Not set

Research Site, Lipa City, Not set

Research Site, Manadaluyong City, Not set

Research Site, Puerto Princesa City, Not set

Research Site, Quezon City, Not set

Research Site, Roxas City, Not set

Research Site, Biała Podlaska, Not set

Research Site, Białystok, Not set

Research Site, Bydgoszcz, Not set

Research Site, Chojnice, Not set

Research Site, Chrzanów, Not set

Research Site, Częstochowa, Not set

Research Site, Gdańsk, Not set

Research Site, Gdynia, Not set

Research Site, Jasło, Not set

Research Site, Katowice, Not set

Research Site, Krakow, Not set

Research Site, Kraków, Not set

Research Site, Lublin, Not set

Research Site, Myszków, Not set

Research Site, Olsztyn, Not set

Research Site, Ostrów Mazowiecka, Not set

Research Site, Piaseczno, Not set

Research Site, Piekary Śląskie, Not set

Research Site, Poznań, Not set

Research Site, Przemyśl, Not set

Research Site, Płock, Not set

Research Site, Radzionków, Not set

Research Site, Rzeszów, Not set

Research Site, Skórzewo, Not set

Research Site, Szczecin, Not set

Research Site, Tarnów, Not set

Research Site, Toruń, Not set

Research Site, Warszawa, Not set

Research Site, Wrocław, Not set

Research Site, Zabrze, Not set

Research Site, Łódź, Not set

Research Site, Bacau, Not set

Research Site, Baia Mare, Not set

Research Site, Brasov, Not set

Research Site, Bucharest, Not set

Research Site, Bucuresti, Not set

Research Site, Craiova, Not set

Research Site, Iasi, Not set

Research Site, Ploiesti, Not set

Research Site, Satu Mare, Not set

Research Site, Targu Mures, Not set

Research Site, Bratislava, Not set

Research Site, Brezno, Not set

Research Site, Kosice, Not set

Research Site, Košice, Not set

Research Site, Lucenec, Not set

Research Site, Malacky, Not set

Research Site, Namestovo, Not set

Research Site, Prievidza, Not set

Research Site, Rimavska Sobota, Not set

Research Site, Roznava, Not set

Research Site, Sabinov, Not set

Research Site, Svidník, Not set

Research Site, Ľubochňa, Not set

Research Site, Benoni, Not set

Research Site, Brackenfell, Not set

Research Site, Cape Town, Not set

Research Site, Centurion, Not set

Research Site, Diepkloof, Soweto, Not set

Research Site, Durban, Not set

Research Site, East London, Not set

Research Site, George, Not set

Research Site, Lenasia, Not set

Research Site, Midrand, Not set

Research Site, Paarl, Not set

Research Site, Parow, Not set

Research Site, Pretoria, Not set

Research Site, Somerset West, Not set

Research Site, Umkomaas, Not set

Research Site, Worcester, Not set

Research Site, A Coruña, Not set

Research Site, Barcelona, Not set

Research Site, Cordoba, Not set

Research Site, Hospitalet de Llobregat(Barcel, Not set

Research Site, Madrid, Not set

Research Site, Málaga, Not set

Research Site, Sant Joan Despi, Not set

Research Site, Santiago(A Coruña), Not set

Research Site, Sevilla, Not set

Research Site, Valencia, Not set

Research Site, Vigo, Not set

Research Site, Göteborg, Not set

Research Site, Helsingborg, Not set

Research Site, Huddinge, Not set

Research Site, Lund, Not set

Research Site, Mölndal, Not set

Research Site, Norrköping, Not set

Research Site, Stockholm, Not set

Research Site, Uppsala, Not set

Research Site, Changhua, Not set

Research Site, Hsinchu, Not set

Research Site, Hualien City, Not set

Research Site, Kaohsiung, Not set

Research Site, New Taipei, Not set

Research Site, Taichung City, Not set

Research Site, Taichung, Not set

Research Site, Tainan, Not set

Research Site, Taipei City, Not set

Research Site, Taipei, Not set

Research Site, Taoyuan, Not set

Research Site, Bangkok, Not set

Research Site, Banphaeo, Not set

Research Site, Bansuan, Muang, Chonburi, Not set

Research Site, Chiang Mai, Not set

Research Site, Dusit, Not set

Research Site, Hat Yai, Not set

Research Site, Khlong Luang, Not set

Research Site, Khon Kaen, Not set

Research Site, Muang, Not set

Research Site, Naimuang, Not set

Research Site, Ubonratchathani, Not set

Research Site, Adana, Not set

Research Site, Afyonkarahisar, Not set

Research Site, Ankara, Not set

Research Site, Antalya, Not set

Research Site, Eskisehir, Not set

Research Site, Istanbul, Not set

Research Site, Izmir, Not set

Research Site, Kahramanmaras, Not set

Research Site, Kocaeli, Not set

Research Site, Kütahya, Not set

Research Site, Malatya, Not set

Research Site, Samsun, Not set

Research Site, Sivas, Not set

Research Site, Chernivtsі, Not set

Research Site, Ivano-Frankivsk, Not set

Research Site, Kyiv, Not set

Research Site, Ternopil, Not set

Research Site, Uzhhorod, Not set

Research Site, Vinnytsia, Not set

Research Site, Zhytomyr, Not set

Research Site, Aberdeen, Not set

Research Site, Chesterfield, Not set

Research Site, Dundee, Not set

Research Site, Gatley, Not set

Research Site, Glasgow, Not set

Research Site, London, Not set

Research Site, Norwich, Not set

Research Site, Penzance, Not set

Research Site, Redruth, Not set

Research Site, Sandbach, Not set

Research Site, Southampton, Not set

Research Site, Stockton-on-Tees, Not set

Research Site, Swansea, Not set

Research Site, Weston-Super-Mare, Not set

Research Site, Wolverhampton, Not set

Research Site, Woodbridge, Not set

Research Site, Yate, Not set

Research Site, Ha Noi, Not set

Research Site, Hai Phong, Not set

Research Site, Hanoi, Not set

Research Site, Hcmc, Not set

Research Site, Ho Chi Minh City, Not set

Research Site, Ho Chi Minh, Not set

Research Site, Hue, Not set

Research Site, Vinh Yen, Not set

Conditions: Heart Failure

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Early Feasibility Study of the NORM™ System in Heart Failure Patients (FUTURE-HFII)

NCT05763407

Recruiting

Early Feasibility Study of the NORM™ System in Heart Failure Patients

Gender:

ALL

Ages:

18 years and above

Trial Updated:

05/28/2025

Locations: Columbia University Irving Medical Center/ New York Presbyterian Hospital, New York, New York +5 locations

Conditions: Heart Failure

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Sotagliflozin to Slow Kidney Function Decline in Persons With Type 1 Diabetes and Diabetic Kidney Disease

NCT06217302

Recruiting

Powerful new drugs that can prevent or delay end stage kidney disease (ESKD) - so called sodium-glucose cotransporter-2 inhibitors (SGLT2i) - are now available for patients with type 2 diabetes. Whether these drugs have similar effects in patients with type 1 diabetes (T1D) remains unknown because of the few studies in this population, due to concerns about the increase in risk of diabetic ketoacidosis (DKA, a serious, potentially fatal acute complication of diabetes due to the accumulation of substances called ketone bodies) observed with SGLT2i therapy in T1D. One of the few T1D studies conducted to date showed that implementing an enhanced DKA prevention plan can reduce the risk of DKA associated with the SGLT2i sotagliflozin (SOTA) to very low levels. In the present study, a similar DKA prevention program will be used to carry-out a 3-year trial to test the kidney benefit of SOTA in 150 persons with T1D and moderate to advanced DKD. After a 2-month period, during which diabetes care will be standardized and education on monitoring and minimizing DKA implemented, eligible study subjects will be randomly assigned (50/50) to take one tablet of SOTA (200 mg) or a similarly looking inactive tablet (placebo) every day for 3 years followed by 2-months without treatment. Neither the participants nor the study staff will know whether a person was assigned to taking SOTA or the inactive tablet. Kidney function at the end of the study will be compared between the two treatment groups to see whether SOTA prevented kidney function loss in those treated with this drug as compared to those who took the inactive tablet. The DKA prevention program will include participant education, close follow-up with study staff, continuous glucose monitoring, and systematic ketone body self-monitoring with a meter provided by the study. If successful, this study will provide efficacy and safety data that could be used to seek FDA approval of SOTA for the prevention of kidney function decline in patients with T1D and DKD. Read Less

Gender:

ALL

Ages:

Between 18 years and 75 years

Trial Updated:

05/28/2025

Locations: Stanford University Medical Center, Stanford, California +17 locations

Conditions: Diabetic Nephropathies, Kidney Failure, Chronic, Diabetes Mellitus Type 1, Heart Failure

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Study to Evaluate Safety, Tolerability and Drug Levels of BMS-986435/MYK-224 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)

NCT06122779

Recruiting

The purpose of this study is to evaluate the safety, tolerability, and exposure-response (E-R) of BMS-986435/MYK-224 in participants with symptomatic Heart Failure with Preserved Ejection Fraction (HFpEF).

Gender:

ALL

Ages:

Between 40 years and 90 years

Trial Updated:

05/27/2025

Locations: University of Alabama at Birmingham, Birmingham, Alabama +114 locations

University of Alabama at Birmingham, Birmingham, Alabama

Local Institution - 0096, Lakewood, Colorado

Local Institution - 0077, Jacksonville, Florida

Infinite Clinical Research, Miami, Florida

Local Institution - 0099, Miami, Florida

Local Institution - 0014, Atlanta, Georgia

Local Institution - 0048, Atlanta, Georgia

Bluhm Cardiovascular Institute of Northwestern, Chicago, Illinois

Chicago Medical Research, LLC, Hazel Crest, Illinois

Ascension Medical Group St. Vincent - Indianapolis Heart Care, Indianapolis, Indiana

Local Institution - 0045, Indianapolis, Indiana

St. Louis Heart and Vascular, Saint Louis, Missouri

Local Institution - 0043, Saint Louis, Missouri

Local Institution - 0070, Albany, New York

Local Institution - 0105, Brooklyn, New York

Weill Cornell Medicine, New York, New York

Local Institution - 0059, Rochester, New York

Local Institution - 0076, Rochester, New York

Local Institution - 0094, Rosedale, New York

Local Institution - 0095, Durham, North Carolina

Local Institution - 0058, Cincinnati, Ohio

Local Institution - 0041, Oklahoma City, Oklahoma

South Oklahoma Heart Research, Oklahoma City, Oklahoma

Local Institution - 0078, Abington, Pennsylvania

Tennessee Center for Clinical Trials, Tullahoma, Tennessee

Local Institution - 0104, Austin, Texas

University of Texas Southwestern Medical Center, Dallas, Texas

Angiocardiac Care of Texas - PA - PPDS, Houston, Texas

Local Institution - 0051, Houston, Texas

Local Institution - 0066, Falls Church, Virginia

Local Institution - 0060, Ciudad Autónoma de Buenos Aires, Buenos Aires

Local Institution - 0054, General San Martín, Buenos Aires

Local Institution - 0107, Zárate, Buenos Aires

Local Institution - 0115, Zárate, Buenos Aires

Local Institution - 0090, Córdoba, Cordoba

Local Institution - 0053, Córdoba, Cordoba

Local Institution - 0073, Rosario, Santa FE

Local Institution - 0061, San Miguel De Tucumán, Tucuman

Local Institution - 0067, Ciudad Autonoma de Buenos Aires, Not set

Local Institution - 0068, Ciudad Autónoma de Buenos Aires, Not set

Local Institution - 0074, Córdoba, Not set

Local Institution - 0069, Salta, Not set

Local Institution - 0102, Santa Fe, Not set

Hamilton General Hospital, Hamilton, Ontario

Medicus MFC Inc., Toronto, Ontario

Local Institution - 0030, Toronto, Ontario

Local Institution - 0040, Toronto, Ontario

Local Institution - 0011, Montreal, Quebec

Local Institution - 0035, Trois-Rivieres, Quebec

Peking Union Medical College Hospital, Beijing, Beijing

Local Institution - 0087, Guangzhou, Guangdong

Local Institution - 0080, Luoyang, Henan

Local Institution - 0079, Changsha, Hunan

The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang

Local Institution - 0109, Jerusalem, Yerushalayim

Local Institution - 0113, Jerusalem, Yerushalayim

Local Institution - 0112, Be'er - Ya'akov, Not set

Local Institution - 0111, Be'er Sheva, Not set

Local Institution - 0108, Haifa, Not set

Local Institution - 0110, Petah Tikva, Not set

Local Institution - 0106, Rehovot, Not set

Local Institution - 0019, Napoli, Campania

Local Institution - 0023, Milano, Lombardia

Local Institution - 0033, Milano, Lombardia

IRCCS Policlinico San Donato, San Donato Milanese, Lombardia

Local Institution - 0050, San Donato Milanese, Lombardia

Local Institution - 0027, Foggia, Puglia

Local Institution - 0038, Foggia, Puglia

Local Institution - 0052, Massa, Toscana

Local Institution - 0009, Bergamo, Not set

Local Institution - 0017, Pisa, Not set

Local Institution - 0092, Himeji-Shi, Hyogo

Local Institution - 0100, Kanazawa, Ishikawa

Local Institution - 0091, Okayama-Shi, Okayama

Local Institution - 0093, Kishiwada, Osaka

Local Institution - 0103, Takatsuki-Shi, Osaka

Local Institution - 0088, Daegu, Daegu Gwang'yeogsi

Local Institution - 0084, Daejeon, Daejeon Gwang'yeogsi

Local Institution - 0083, Gwangju, Gwangju Gwang'yeogsi

Inha University Hospital, Jung-gu, Incheon Gwang'yeogsi

Local Institution - 0085, Seoul, Seoul Teugbyeolsi

Local Institution - 0114, Seoul, Seoul Teugbyeolsi

Local Institution - 0055, Seoul, Seoul Teugbyeolsi

Local Institution - 0086, Busan, Not set

Local Institution - 0098, Seongnam-si, Not set

Local Institution - 0081, Seoul, Not set

Clinical Trials UMED Sp. z o.o., Lódz, Lódzkie

Local Institution - 0031, Bialystok, Podlaskie

Local Institution - 0044, Bialystok, Podlaskie

Local Institution - 0020, Lublin, Woj. Lubelskie

Local Institution - 0049, Lublin, Woj. Lubelskie

Local Institution - 0006, Krakow, Not set

Local Institution - 0024, Oswiecim, Not set

Local Institution - 0012, Hospitalet de Llobregat, Barcelona

Local Institution - 0025, Majadahonda, Madrid

Local Institution - 0047, Majadahonda, Madrid

Hospital Universitario Virgen de La Arrixaca, El Palmar, Murcia

Local Institution - 0039, El Palmar, Murcia

Local Institution - 0042, Malaga, Málaga

Local Institution - 0026, Madrid, Not set

Local Institution - 0034, Madrid, Not set

Local Institution - 0032, Malaga, Not set

Hospital Nuestra Señora de Valme, Sevilla, Not set

Local Institution - 0046, Sevilla, Not set

Local Institution - 0010, Valencia, Not set

Local Institution - 0063, Harrow, Greater London

Local Institution - 0071, North Shields, Northumberland

Local Institution - 0062, Oxford, Oxfordshire

Local Institution - 0072, Leeds, Yorkshire

Local Institution - 0057, Sheffield, Yorkshire

Local Institution - 0101, Bristol, Not set

Local Institution - 0097, Dundee, Not set

Local Institution - 0075, London, Not set

Local Institution - 0065, Stockton-On-Tees, Not set

Local Institution - 0064, Wolverhampton, Not set

Conditions: Heart Failure

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Acalabrutinib Monotherapy vs Investigator's Choice of Treatment in Patients With CL Leukaemia and Heart Failure

NCT06651970

Recruiting

This will be a global Phase IV, open-label, randomised study to evaluate the safety and tolerability of acalabrutinib (monotherapy, 100 mg orally \[po\], twice daily \[bd\]) compared to investigator's choice of treatment, in patients with CLL (TN or R/R) and moderate to severe cardiac impairment. All patients will have cardiac impairment as defined by LVEF of \< 50%. Randomisation will be stratified by LVEF \> 40% vs ≤ 40% to stratify for moderate and severe cardiac impairment, which for this s... Read More

Gender:

ALL

Ages:

Between 18 years and 130 years

Trial Updated:

05/26/2025

Locations: Research Site, Charlotte, North Carolina +22 locations

Conditions: Chronic Lymphocytic Leukaemia, Heart Failure

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A Multi-center, National, Open-label, Prospective Study to Evaluate the Performance of the V-Lap™ System

NCT06147336

Recruiting

The objective of this study is to evaluate the safety and performance of the V-LAP System in subjects with New York Heart Association (NYHA) functional class II and III HF, irrespective of left ventricular ejection fraction.

Gender:

ALL

Ages:

Between 22 years and 88 years

Trial Updated:

05/25/2025

Locations: One Boston Medical Center Place, Boston, Massachusetts

Conditions: Heart Failure

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