There are currently 76 active clinical trials seeking participants for Obstructive Sleep Apnea research studies. The states with the highest number of trials for Obstructive Sleep Apnea participants are California, Ohio, Florida and Pennsylvania.
Atomoxetine and DAW2022 on OSA Severity
Recruiting
Obstructive sleep apnea (OSA) is common and has major health implications but treatment options are limited. In previous research atomoxetine and oxybutynin showed promising effect at reducing OSA severity, however they reduced arousal threshold, one of the key traits responsible for OSA. Since oxybutynin was used mainly as a hypnotic, but it is burdened by several anti-cholinergic side effects, DAW2020, a hypnotic which prolonged the total sleep time in a previous trial in OSA patients, could b... Read More
Gender:
All
Ages:
Between 21 years and 70 years
Trial Updated:
07/05/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Obstructive Sleep Apnea
Postoperative Neurocognitive Disorders
Recruiting
The purpose of this study is to examine the mechanisms of brain injury contributing to postoperative neurocognitive disorders (PNCD) in an at-risk population (obstructive sleep apnea (OSA)) undergoing surgery. The investigators will enroll 50 OSA patients scheduled for surgery. All patients will have a brain scan (fMRI) within five days before surgery and two days and six months after surgery. During this visit cognitive function will be assessed using the Wide Range Assessment of Memory and Lea... Read More
Gender:
All
Ages:
Between 40 years and 75 years
Trial Updated:
04/26/2023
Locations: Ronald Reagan UCLA Medical Center, Department of Anesthesiology & Perioperative Medicine, Los Angeles, California
Conditions: Obstructive Sleep Apnea, Neurocognitive Disorders
Pharmacological Activation of HMN for OSA Aim 2
Recruiting
Obstructive sleep apnea (OSA) is common and has major health implications but treatment options are limited. OSA patients show a marked reduction in upper airway (UA) dilator muscle activity at sleep onset and this phenomenon leads to increased collapsibility of UA compared to normal subjects. In this protocol the investigators will test the effect of LTM1201AZ, LTM1201AT, LTM1201AD, LTM1201AG administered before sleep on OSA phenotype traits and OSA severity during sleep.
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
09/19/2022
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Obstructive Sleep Apnea
Capnography in the Post-Anesthesia Care Unit (PACU)
Recruiting
To understand if a progressive increase in end-tidal carbon dioxide (CO2) levels are heralding respiratory difficulties before desaturation measured from capnography in obstructive sleep apnea patients, with the use of nasal prongs, transcutaneous monitors, Capnostream, and Massimo technologies.
Gender:
All
Ages:
18 years and above
Trial Updated:
06/23/2022
Locations: Tampa General Hospital, Tampa, Florida
Conditions: Obstructive Sleep Apnea, Bariatric Surgery Candidate, Respiratory Insufficiency