An Efficacy, Safety, Tolerability and Dose Finding Study of XXB750 in Resistant Hypertension Patients.
Recruiting
The purpose of this 20-week randomized double-blind study in patients with resistant hypertension (rHTN) is to evaluate the efficacy, safety, and tolerability, of different doses of XXB750 administered as subcutaneous (SC) injections, compared to placebo. Since all study participants will be patients with rHTN, all study treatments will be given on top of maximally tolerated background antihypertensive therapy recommended by international guidelines for treatment of HTN (i.e., a thiazide or a th... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
10/27/2023
Locations: Novartis Investigative Site, Anniston, Alabama +108 locations
Conditions: Resistant Hypertension
Allopurinol Improves Heart Function in African Americans With Resistant Hypertension
Recruiting
African American adults in the United States have the highest prevalence rate of high blood pressure (hypertension) and heart failure in the world. African Americans with treatment resistant hypertension have higher levels of the enzyme - xanthine oxidase compared to Caucasians. This trial will test if administration of the xanthine oxidase inhibitor - Allopurinol (commonly used in the treatment of gout), given over a period of 8 weeks, will improve heart function, exercise ability and quality o... Read More
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
08/17/2023
Locations: Birmingham VA Medical Center, Birmingham, AL, Birmingham, Alabama
Conditions: Heart Failure Preserved Ejection Fraction, Resistant Hypertension