District Of Columbia is currently home to 920 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Washington, Washington, D.C., Washington DC and Washington, Dc. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure With Preserved Ejection Fraction
NCT02901184
Recruiting
Heart failure with preserved ejection fraction (HFPEF) is common and deadly but without therapy. Inconclusive studies such as TOPCAT (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist) suggest spironolactone may be effective in HFPEF, but it is generic and will not be studied by industry. SPIRRIT is a unique Registry-Randomized Clinical Trial (RRCT) that will test the hypothesis that spironolactone plus standard of care compared to standard of care alone reduc... Read More
Gender:
All
Ages:
Between 50 years and 99 years
Trial Updated:
02/15/2024
Locations: MedStar Cardiovascular Research Network, Washington, District of Columbia
Conditions: Heart Failure With Preserved Ejection Fraction
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A Phase 2 Study of Sonodynamic Therapy Using SONALA-001 and Exablate 4000 Type 2.0 in Patients With DIPG
NCT05123534
Recruiting
The primary objectives of this trial are to evaluate the safety and tolerability of sonodynamic therapy (SDT) using SONALA-001 and Exablate Type 2.0 device and to determine the maximum tolerated dose (MTD) or recommended phase 2 dose (RP2D) of MR-Guided Focused Ultrasound (MRgFUS) energy in combination with SONALA-001 in subjects with diffuse intrinsic pontine glioma Funding Source - FDA OOPD
Gender:
All
Ages:
5 years and above
Trial Updated:
02/14/2024
Locations: Children's National / Children's Research Institute, Washington, District of Columbia
Conditions: Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma
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A Patient and Provider Intervention to Address Health Disparities in Lung Cancer Screening
NCT04675476
Recruiting
To test the impact of a multilevel intervention on primary (provider-patient communication, intentions, and knowledge) and secondary (screening referrals and completion) outcomes.
Gender:
All
Ages:
Between 50 years and 80 years
Trial Updated:
02/14/2024
Locations: MedStar Health, Washington, District of Columbia
Conditions: Lung Cancer
Register for Updates
Bentracimab in Ticagrelor-treated Patients With Uncontrolled Bleeding or Requiring Urgent Surgery or Invasive Procedure
NCT04286438
Recruiting
This is a multi-center, open-label, prospective single-arm study of reversal of the antiplatelet effects of ticagrelor with bentracimab (PB2452) in patients who present with uncontrolled major or life-threatening bleeding or who require urgent surgery or invasive procedure. At least 200 patients will be enrolled from approximately 200 centers in North America, Europe, and Asia-Pacific regions, including mainland China. Patients with reported use of ticagrelor within the prior 3 days who require... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/14/2024
Locations: MedStar Health Research Institute, Washington, District of Columbia
Conditions: Hemorrhage, Urgent Surgery, Invasive Procedure
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Study to Investigate the Efficacy, Safety, and Tolerability of Topical HT-001 for the Treatment of Skin Toxicities Associated With Epidermal Growth Factor Receptor Inhibitors
NCT05639933
Recruiting
The goal of this clinical trial is to learn about HT-001 Topical Gel for treatment of EGFR inhibitor-induced skin toxicities. The main questions it aims to answer are: Determine the therapeutic effect of HT-001 for treatment of patients who develop acneiform rash undergoing Epidermal Growth Factor inhibitor (EGFRI) therapy using the acneiform rash investigator's global assessment scale [ARIGA] Evaluate the safety of HT-001 during treatment Participants will apply HT-001 Gel once per day for 6... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/13/2024
Locations: The George Washington University Medical Faculty Associates, Washington, District of Columbia
Conditions: Acneiform Eruption Due to Chemical, Xerosis Cutis, Paronychia
Register for Updates
Observational Study of Pediatric Rheumatic Diseases: The CARRA Registry
NCT02418442
Recruiting
Continuation of the CARRA Registry as described in the protocol will support data collection on patients with pediatric-onset rheumatic diseases. The CARRA Registry will form the basis for future CARRA studies. In particular, this observational registry will be used to answer pressing questions about therapeutics used to treat pediatric rheumatic diseases, including safety questions.
Gender:
All
Ages:
21 years and below
Trial Updated:
02/13/2024
Locations: Childrens National Medical Center, Washington, District of Columbia
Conditions: Rheumatic Joint Disease
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Neoadjuvant Pembrolizumab and IO102-103 for Squamous Cell Carcinoma of the Head and Neck (SCCHN).
NCT05977907
Recruiting
This research is being done to see if it is safe to give investigational combination of study drugs (Pembrolizumab and IO102-103) before surgery to people with surgically resectable (removable) newly diagnosed or recurrent metastatic SCCHN. This will be done by watching participants closely for possible side effects from Pembrolizumab and IO102-103. In addition, participants will be monitored for any delays to their surgery due to the study drugs.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/12/2024
Locations: Sibley Memorial Hospital, Washington, District of Columbia
Conditions: Head and Neck Squamous Cell Carcinoma
Register for Updates
International Rare Brain Tumor Registry
NCT05697874
Recruiting
The objective of the International Rare Brain Tumor Registry (IRBTR) is to better understand rare brain tumors through the collection of biospecimens and matched clinical data of children, adolescents, and young adult patients diagnosed with rare brain tumors.
Gender:
All
Ages:
45 years and below
Trial Updated:
02/12/2024
Locations: Children's National Hospital, Washington, District of Columbia
Conditions: Astroblastoma, BCOR ITD Sarcoma, CNS Sarcoma, Unclassified Tumor, Malignant
Register for Updates
IN.PACT™ AV Access Post-Approval Study (PAS002)
NCT04543539
Recruiting
Long-term safety will be summarized
Gender:
All
Ages:
21 years and above
Trial Updated:
02/12/2024
Locations: Medstar Washington Hospital, Washington, District of Columbia
Conditions: Arteriovenous Fistula, Arteriovenous Fistula Stenosis, Arteriovenous Fistula Occlusion, Fistula
Register for Updates
Pilot Imaging Study of Leukemia
NCT03633955
Recruiting
This is a prospective pilot study, the primary aim of which is to determine whether the presence of 18F FLT imaging signal uptake abnormalities correlate with clinically validated evidence of hematopoietic malignant disease (e.g. MRD, molecular, flow or histology) after immunotherapy and other treatments.
Gender:
All
Ages:
Between 4 years and 80 years
Trial Updated:
02/12/2024
Locations: Children's National Health System, Washington, District of Columbia
Conditions: Acute Lymphocytic Leukemia, Acute Myeloid Leukemia, Ambiguous Lineage Leukemia or Lymphoma, Myeloma
Register for Updates
SELUTION 4 De Novo Small Vessel IDE Trial
NCT05946629
Recruiting
Prospective, randomized controlled, single-blind, multicenter, clinical trial to demonstrate the safety and efficacy of the SELUTION SLR 014 PTCA DEB for treatment of de novo lesions in small coronary vessels, defined as reference vessel diameter (RVD) of 2.00 mm to 2.75 mm, in support of a pre-market approval (PMA) application to the United States (US) FDA. The Study will enroll up to 910 randomized subjects, up to 30 subjects in a parallel angiographic substudy, and up to 20 subjects in a par... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/10/2024
Locations: MedStar Washington Hospital Center, Washington, District of Columbia
Conditions: Coronary Artery Disease
Register for Updates
Longitudinal Study of Urea Cycle Disorders
NCT00237315
Recruiting
Urea cycle disorders (UCD) are a group of rare inherited metabolism disorders. Infants and children with UCD commonly experience episodes of vomiting, lethargy, and coma. The purpose of this study is to perform a long-term analysis of a large group of individuals with various UCDs. The study will focus on the natural history, disease progression, treatment, and outcome of individuals with UCD.
Gender:
All
Ages:
All
Trial Updated:
02/10/2024
Locations: Children's National Medical Center, Washington, District of Columbia
Conditions: Brain Diseases, Metabolic, Inborn, Amino Acid Metabolism, Inborn Errors, Urea Cycle Disorders
Register for Updates