District Of Columbia is currently home to 918 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Washington, Washington, D.C., Washington DC and Washington, Dc. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Evaluating the Effectiveness of a Cognitive Behavioral Intervention (CBI)
NCT05782348
Recruiting
This is a Phase III, randomized, one-center, three arm parallel group, open label and single blind clinical study to evaluate the effectiveness of a cognitive behavioral intervention (CBI) adjunctive to a smart powered toothbrush on the oral health of adolescents.
Gender:
All
Ages:
Between 14 years and 17 years
Trial Updated:
03/13/2023
Locations: Friendship Public Charter School, Washington, District of Columbia
Conditions: Adolescent Behavior, Dental Plaque, Gingivitis, Cognitive Change
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Omalizumab Before Onset of Exacerbations
NCT05332067
Recruiting
OBOE is a prospective, pilot, parallel group RCT with the overall aim of examining the effect of a single dose of anti-IgE (omalizumab) vs. placebo administered at the onset of URIs in the fall season among highly exacerbation-prone, urban, and atopic youth aged 6-17 years with persistent asthma. OBOE will recruit and randomize participants over 3 years (3 annual cohorts of participants). Recruitment for each of the yearly cohorts of OBOE will begin in February. Each cohort will be followed for... Read More
Gender:
All
Ages:
Between 6 years and 17 years
Trial Updated:
03/13/2023
Locations: Children's National Hospital, Washington, District of Columbia
Conditions: Asthma in Children, Atopy, Viral Upper Respiratory Infection
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Cobimetinib in Refractory Langerhans Cell Histiocytosis (LCH), and Other Histiocytic Disorders
NCT04079179
Recruiting
This is a research study of a drug called cobimetinib in children and adults diagnosed with Langerhans cell histiocytosis (LCH), and other histiocytic disorders that has returned or does not respond to treatment. Cobimetinib blocks activation of a protein called Mitogen-activated protein kinase (MEK) that is part of incorrect growth signals in histiocytosis cells. Four different groups of patients will be enrolled.
Gender:
All
Ages:
All
Trial Updated:
03/13/2023
Locations: Children's National Hospital, Washington, District of Columbia
Conditions: Langerhan's Cell Histiocytosis, Juvenile Xanthogranuloma, Erdheim-Chester Disease, Rosai Dorfman Disease, Neuro-Degenerative Disease, Histiocytic Sarcoma, Histiocytic Disorders, Malignant
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Artificial Intelligence Mobile Health Trial Of A Digital Platform To Optimize GDMT Using Wearable Sensors
NCT04191330
Recruiting
The goal of this real-world, multi-center, randomized, outpatient study is to assess the effectiveness of the Biofourmis cloud based BiovitalsHFTM platform to recommend optimal titration of Guideline-Directed Medical Therapy (GDMT) for heart failure with reduced ejection fraction (HFrEF) subjects.
Gender:
All
Ages:
22 years and above
Trial Updated:
03/09/2023
Locations: Medstar Washington Hospital Center, Washington, District of Columbia
Conditions: Heart Failure
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Older Breast Cancer Patients: Risk for Cognitive Decline
NCT03451383
Recruiting
The goal of this study is to evaluate the impact of systemic therapy on cognition in older breast cancer patients, explore change in APE, LM and Cognition domains, measure associations between cognitive decline and QOL, and describe how genetic polymorphisms, inflammatory biomarkers, sleep and physical measures moderate cognitive outcomes. This study is being done nationally, with recruiting sites at Georgetown University, Montgomery General Hospital, Virginia Cancer Specialists, Washington Hosp... Read More
Gender:
Female
Ages:
Between 60 years and 105 years
Trial Updated:
03/09/2023
Locations: Georgetown University, Washington, District of Columbia
Conditions: Cancer, Breast, Age-related Cognitive Decline, Cognitive Decline
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Improving Genetic Counseling for BRCA+ Mothers
NCT04258280
Recruiting
Genetic counseling and testing for hereditary breast cancer may reveal that you, and possibly your blood relatives, are at increased risk for the disease across the lifespan. This includes biological children, both male and female. We do not yet know the best ways to educate mothers who have a risk gene (are BRCA+) about whether, when, and how to share genetic information with their children or manage their thoughts and feelings. The purpose of this study is to help mothers make more informed ch... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
02/22/2023
Locations: MedStar Georgetown University Hospital, Washington, District of Columbia
Conditions: Breast Cancer
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Quality of Life in Patients With Clinically Localized Prostate Cancer Treated With Radiosurgery
NCT01766492
Recruiting
Quality of life data following SBRT for prostate cancer has been obtained in only a small numbers of patients. A prospective study using validated quality of life questionnaires is needed to determine outcomes after treatment with SBRT. Our study will be the first essential step in developing a better evidence base on the comparative risks and benefits of SBRT treatment with regards to quality of life assessment and outcomes.
Gender:
Male
Ages:
Between 18 years and 99 years
Trial Updated:
02/22/2023
Locations: Georgetown University Hospital, Washington, District of Columbia
Conditions: Prostate Cancer, Localized Malignant Neoplasm
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Measuring Impact of Computer Gaming on Arm Use in Rett Syndrome
NCT05012475
Recruiting
Using a tele-research approach, we will recruit, enroll, guide and support carers and participants to engage in computer based activities (modified virtual reality) with the primary outcome of reducing stereotypies and increasing independent arm and hand use and secondary outcome of improving quality of living. Because of our virtual approach, we are able to recruit from multiple countries and all states and territories of the USA.
Gender:
All
Ages:
Between 4 years and 60 years
Trial Updated:
02/21/2023
Locations: Georgetown University School of Medicine, Washington, District of Columbia
Conditions: Rett Syndrome
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Technology-Enhanced Executive Functioning Intervention for ADHD
NCT04729439
Recruiting
This study develops and refines an online platform that will support clinician-directed behavioral and organizational skills intervention for adolescents with Attention-Deficit/Hyperactivity Disorder (ADHD) with input guided from key stakeholders during focus groups and interviews (phase 1), extended usability testing (phase 2), and a pilot randomized trial (phase 3) of the online tool used in conjunction with an organizational skills intervention.
Gender:
All
Ages:
Between 11 years and 14 years
Trial Updated:
02/20/2023
Locations: Children's National Research Institute, Washington, District of Columbia
Conditions: ADHD, Attention Deficit Hyperactivity Disorder, Attention Deficit Disorder, ADD, ADHD Predominantly Inattentive Type, ADHD - Combined Type, ADHD, Predominantly Hyperactive - Impulsive, Attention-Deficit Disorder in Adolescence, Attention-Deficit Hyperactivity Disorder Symptoms, Attention-Deficit Hyperactivity Disorder
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Prospective Research Assessment in Multiple Myeloma: An Observational Evaluation (PREAMBLE)
NCT01838512
Recruiting
The purpose of this study is to assess the clinical effectiveness of all approved multiple myeloma (MM) therapies in the newly-diagnosed (NDMM) and the relapsed/refractory MM (RRMM) settings in real-world clinical practice.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/16/2023
Locations: Local Institution - 0057, Washington, District of Columbia
Conditions: Multiple Myeloma
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Clinical Study Of a Micro-Implantable Pulse Generator For The Treatment of Peripheral Neuropathic Pain
NCT05287373
Recruiting
This post market study is being conducted to document the comparative effectiveness and safety of peripheral nerve stimulation plus conventional medical management versus conventional medical management alone in the treatment of chronic, intractable peripheral neuralgia of post-traumatic or post-surgical origin. This is a prospective, minimal risk, multi-center, randomized control trial.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
02/13/2023
Locations: International Spine, Pain and Performance Center, Washington, District of Columbia
Conditions: Peripheral Neuralgia, Chronic Pain
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Neuroimaging and Neuropsychological Outcomes in Urea Cycle Disorders
NCT02935283
Recruiting
In proximal urea cycle disorders (UCD), particularly ornithine transcarbamylase deficiency (OTCD), hyperammonemia (HA) causes increased brain glutamine (Gln) which perturbation is thought to be at the core of the neurological injury. In contrast, in distal UCD such as citrullinemia (argininosuccinate synthetase deficiency; (ASSD) and argininosuccinic aciduria (argininosuccinate lyase deficiency); (ASLD) cognitive impairment and neuropsychiatric disease are common even in the absence of acute HA.... Read More
Gender:
All
Ages:
Between 7 years and 50 years
Trial Updated:
02/11/2023
Locations: Children's Research Institute, Washington, District of Columbia
Conditions: Urea Cycle Disorders
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