District Of Columbia is currently home to 862 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Washington, Washington, D.C., Washington DC and Washington, Dc. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Impact of Nilotinib on Safety, Tolerability, Pharmacokinetics and Biomarkers in Dementia With Lewy Bodies
NCT04002674
Recruiting
Dementia with Lewy Bodies (DLB) is an alphasynucleinopathy and the second most common form of dementia in the elderly. DLB shares striking neuropathological and clinical similarities with both Parkinson's disease (PD) and Alzheimer's disease (AD). Nilotinib (Tasigna®, AMN107, Novartis, Switzerland) is approved by the FDA and is well tolerated for CML treatment at oral doses of 600-800mg daily. The Investigators propose to perform a phase II randomized, double blinded, placebo controlled study to... Read More
Gender:
All
Ages:
Between 25 years and 90 years
Trial Updated:
05/11/2023
Locations: MedStar Georgetown University Hospital, Washington, District of Columbia
Conditions: Dementia With Lewy Bodies
Register for Updates
Helping Toddlers and Parents Together
NCT04864808
Recruiting
Using stakeholder feedback (i.e., behavioral health providers & caregivers), the goal of this study is to develop a behavioral parenting program that focuses on both parent mental health and parenting for parents of toddlers (12-35 months old). Using a deployment focused intervention model, this study will : (1) develop an early parenting intervention for parents of at-risk toddlers which integrates a focus on parent mental health with evidence-based behavioral parenting strategies, and (2) exam... Read More
Gender:
All
Ages:
Between 12 months and 55 years
Trial Updated:
05/09/2023
Locations: Children's National Medical Center, Washington, District of Columbia
Conditions: ADHD, Parenting
Register for Updates
Vibroacoustic Study of Lung Development in Newborn Infants
NCT05827250
Recruiting
Investigators hypothesize that premature newborns with poor cardiopulmonary performance have higher morbidities and poorer physical and cognitive developmental outcomes. Investigators further hypothesize that audible sounds combined with novel inaudible vibrations above and below human perception interpreted with transparent and auditable AI algorithms can detect and identify early gas and fluid movement anomalies not uncovered by conventional tools in an non-invasive, easy, fast, and low cost... Read More
Gender:
All
Ages:
Between 0 years and 2 years
Trial Updated:
04/11/2023
Locations: Medstar Georgetown University Hospital, Washington, District of Columbia
Conditions: Prematurity, Premature Birth, Premature Lungs, Prematurity; Extreme
Register for Updates
LCH-IV, International Collaborative Treatment Protocol for Children and Adolescents With Langerhans Cell Histiocytosis
NCT02205762
Recruiting
The LCH-IV is an international, multicenter, prospective clinical study for pediatric Langerhans Cell Histiocytosis LCH (age < 18 years).
Gender:
All
Ages:
18 years and below
Trial Updated:
03/21/2023
Locations: Children's National Medical Center, Washington, District of Columbia
Conditions: Langerhans Cell Histiocytosis
Register for Updates
Evaluating the Effectiveness of a Cognitive Behavioral Intervention (CBI)
NCT05782348
Recruiting
This is a Phase III, randomized, one-center, three arm parallel group, open label and single blind clinical study to evaluate the effectiveness of a cognitive behavioral intervention (CBI) adjunctive to a smart powered toothbrush on the oral health of adolescents.
Gender:
All
Ages:
Between 14 years and 17 years
Trial Updated:
03/13/2023
Locations: Friendship Public Charter School, Washington, District of Columbia
Conditions: Adolescent Behavior, Dental Plaque, Gingivitis, Cognitive Change
Register for Updates
Omalizumab Before Onset of Exacerbations
NCT05332067
Recruiting
OBOE is a prospective, pilot, parallel group RCT with the overall aim of examining the effect of a single dose of anti-IgE (omalizumab) vs. placebo administered at the onset of URIs in the fall season among highly exacerbation-prone, urban, and atopic youth aged 6-17 years with persistent asthma. OBOE will recruit and randomize participants over 3 years (3 annual cohorts of participants). Recruitment for each of the yearly cohorts of OBOE will begin in February. Each cohort will be followed for... Read More
Gender:
All
Ages:
Between 6 years and 17 years
Trial Updated:
03/13/2023
Locations: Children's National Hospital, Washington, District of Columbia
Conditions: Asthma in Children, Atopy, Viral Upper Respiratory Infection
Register for Updates
Quality of Life in Patients With Clinically Localized Prostate Cancer Treated With Radiosurgery
NCT01766492
Recruiting
Quality of life data following SBRT for prostate cancer has been obtained in only a small numbers of patients. A prospective study using validated quality of life questionnaires is needed to determine outcomes after treatment with SBRT. Our study will be the first essential step in developing a better evidence base on the comparative risks and benefits of SBRT treatment with regards to quality of life assessment and outcomes.
Gender:
Male
Ages:
Between 18 years and 99 years
Trial Updated:
02/22/2023
Locations: Georgetown University Hospital, Washington, District of Columbia
Conditions: Prostate Cancer, Localized Malignant Neoplasm
Register for Updates
Technology-Enhanced Executive Functioning Intervention for ADHD
NCT04729439
Recruiting
This study develops and refines an online platform that will support clinician-directed behavioral and organizational skills intervention for adolescents with Attention-Deficit/Hyperactivity Disorder (ADHD) with input guided from key stakeholders during focus groups and interviews (phase 1), extended usability testing (phase 2), and a pilot randomized trial (phase 3) of the online tool used in conjunction with an organizational skills intervention.
Gender:
All
Ages:
Between 11 years and 14 years
Trial Updated:
02/20/2023
Locations: Children's National Research Institute, Washington, District of Columbia
Conditions: ADHD, Attention Deficit Hyperactivity Disorder, Attention Deficit Disorder, ADD, ADHD Predominantly Inattentive Type, ADHD - Combined Type, ADHD, Predominantly Hyperactive - Impulsive, Attention-Deficit Disorder in Adolescence, Attention-Deficit Hyperactivity Disorder Symptoms, Attention-Deficit Hyperactivity Disorder
Register for Updates
EXCOR Active Driving System for the EXCOR Pediatric VAD IDE Study
NCT05610787
Recruiting
The purpose of this study is to evaluate the device performance and monitor the safety and effectiveness of the Berlin Heart EXCOR Active Driving System while being used with the approved EXCOR Pediatric Ventricular Assist Device. EXCOR Active Driving System is intended for use with the approved EXCOR Pediatric VAD. The EXCOR Pediatric VAD is intended to provide mechanical circulatory support as a bridge to cardiac transplantation for pediatric patients. Pediatric candidates with severe isolat... Read More
Gender:
All
Ages:
21 years and below
Trial Updated:
02/06/2023
Locations: Children's National, Washington, District of Columbia
Conditions: Heart Failure, Transplant; Failure, Heart, Congenital Heart Disease
Register for Updates
Ultrasound for Scoliosis Diagnostic Evaluation
NCT03222739
Recruiting
Scoliosis is a complex 3-dimensional deformity of the spine. It may occur at any time throughout growth and development and is typically detected through x-ray imaging. Although effective at visualizing a curve, x-ray imaging is costly and may expose children to potentially harmful ionizing radiation. This is a 30 patient study to evaluate the reliability of ultrasound, an imaging technique without radiation, to effectively measure scoliosis deformities compared to the gold-standard of x-ray.
Gender:
All
Ages:
Between 7 years and 17 years
Trial Updated:
01/31/2023
Locations: Children's National Health System, Washington, District of Columbia
Conditions: Scoliosis Idiopathic, Scoliosis; Juvenile
Register for Updates
Digital Dysmorphology Project
NCT02651493
Recruiting
In this study, the investigators propose a novel method to detect Down syndrome using photography for facial dysmorphology, a tool called computer-aided diagnosis (CAD). After validating the method, this technology will be expanded to perform similar functions to assist in the detection of other dysmorphic syndromes. By using photography and image analysis this automated assessment tool would have the potential to improve the diagnosis rate and allow for remote, non-invasive diagnostic evaluati... Read More
Gender:
All
Ages:
18 years and below
Trial Updated:
01/31/2023
Locations: Children's National, Washington, District of Columbia
Conditions: Down Syndrome
Register for Updates
Efficacy of EsoGuard Assay on Esophageal Surface Cells Collected With EsoCheck vs EGD for the Diagnosis of BE or EAC
NCT04295811
Recruiting
The study will assess the performance of the combined system, i.e., the use of the EsoGuard assay (lab developed test) on cells collected using the EsoCheck (501k cleared device) to detect Barrett's Esophagus (BE), with or without dysplasia, and esophageal adenocarcinoma (EAC) as compared to Esophagogastroduodenoscopy (EGD) plus biopsies in both confirmed cases of BE/EAC and in controls (subjects without a prior diagnosis but undergoing screening for BE/EAC)
Gender:
Male
Ages:
50 years and above
Trial Updated:
01/23/2023
Locations: Lucid Investigative Site, Washington, District of Columbia
Conditions: Barrett Esophagus, Esophageal Adenocarcinoma, Barretts Esophagus With Dysplasia, Barrett's Esophagus Without Dysplasia
Register for Updates