Jacksonville, FL Clinical Trials

A listing of Jacksonville, FL clinical trials actively recruiting patient volunteers.

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861 trials found

Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY

NCT04916210

The overall goal of the DISCOVERY study is to better understand what factors contribute to changes in cognitive (i.e., thinking and memory) abilities in patients who experienced a stroke. The purpose of the study is to help doctors identify patients at risk for dementia (decline in memory, thinking and other mental abilities that significantly affects daily functioning) after their stroke so that future treatments may be developed to improve outcomes in stroke patients. For this study, a "stroke ...

Conditions: Ischemic Stroke, Intracerebral Hemorrhage, Subarachnoid Hemorrhage, Dementia, Vascular, Mild Cognitive Impairment, Vascular Cognitive Impairment

Exercise Training to Improve Cardiopulmonary Hemodynamics in Heart Failure Patients

NCT04909008

This research study is being done to find out if exercise therapy can help improve the heart function, overall health, and quality of life of patients with pulmonary hypertension caused by heart failure.

Conditions: Heart Failure, Pulmonary Hypertension
Phase: Not Applicable

Intestinal Permeability and Gastroparesis

NCT04894656

The purpose of this study is to investigate potential mechanisms that could lead to the development of a condition known as gastroparesis.

Conditions: Gastroparesis, Healthy
Phase: Not Applicable

Study to Evaluate Adverse Events and Change in Disease Activity in Participants Between 18 to 75 Years of Age Treated With Subcutaneous (SC) Injections of ABBV-154 for Moderately to Severely Active Rheumatoid Arthritis (RA)

NCT04888585

Rheumatoid Arthritis (RA) is an inflammatory disease of the joints causing pain, stiffness, swelling and loss of joint function. This study evaluates how safe and effective ABBV-154 is in participants treated for moderately to severely active RA. Adverse events and change in the disease activity will be assessed. ABBV-154 is an investigational drug being evaluated for the treatment of RA. Study doctors place the participants in 1 of 5 treatment groups or arms, each arm receiving a different tre ...

Conditions: Rheumatoid Arthritis (RA)

Happy Gut Study - Fermented Vegetables and Cardiovascular Biomarkers

NCT04887662

The purpose of this project is to determine whether regular consumption of fermented vegetables can decrease inflammation and change the types of bacteria that are normally present in the large intestine. Recent research studies have linked the gut bacteria to many disorders and conditions, such as obesity, cardiovascular disease, diabetes, etc. We also know that certain bacteria are considered probiotic bacteria because they contribute to a healthy gut, while others have been associated with in ...

Conditions: Cardiovascular Diseases
Phase: Not Applicable

A Study Evaluating the Efficacy and Safety of Adjuvant Atezolizumab or Placebo and Trastuzumab Emtansine for Participants With HER2-Positive Breast Cancer at High Risk of Recurrence Following Preoperative Therapy

NCT04873362

This is a Phase III, two-arm, randomized, double-blind placebo-controlled study in participants with HER2-positive primary breast cancer who have received preoperative chemotherapy and HER2-directed therapy, including trastuzumab followed by surgery, with a finding of residual invasive disease in the breast and/or axillary lymph nodes.

Conditions: Breast Cancer

Efficacy and Safety of COVID-19 Vaccine in Cancer Patients

NCT04865133

This early phase I study gathers information about how the body responds to COVID-19 vaccine during cancer treatment compared to healthy individuals. The information gained may help determine how effective currently available COVID-19 vaccines are in cancer patients receiving chemotherapy and learn more regarding how long an immune response will last compared to healthy individuals.

Conditions: COVID-19 Infection, Malignant Solid Neoplasm

A Study of Lirentelimab (AK002) in Patients With Active Eosinophilic Duodenitis

NCT04856891

This is a Phase 3, multi-center, randomized, double-blind, placebo-controlled study to assess the efficacy and safety of lirentelimab (AK002) given monthly for 6 doses in adult patients with active eosinophilic duodenitis. Subjects who complete the randomized, double-blind, placebo-controlled treatment may have the option to receive 6 doses of open-label lirentelimab (AK002) through the OLE Period of the study.

Conditions: Eosinophilic Duodenitis, Eosinophilic Gastroenteritis

Safety and Efficacy of bb2121 (Ide-cel) Combinations in Multiple Myeloma

NCT04855136

This is a global, open-label, multi-arm, multi-cohort, multi-center, phase 1/2 study to determine the safety, tolerability, efficacy, PK of bb2121 in combination with other therapies in adult subjects with R/RMM. The following combinations will be Arm A will test bb2121 in combination with CC-220 (± low-dose dexamethasone) Arm B will test bb2121 in combination with BMS-986405 (JSMD194) Arm C will test bb2121 in combination with one of the following standard triplet regimens: 1) Daratumumab (DA ...

Conditions: Multiple Myeloma
Phase: Phase 1/2

Evaluation of Dryness in a Silicone Hydrogel Daily Disposable Contact Lens

NCT04849780

This is a multi-site, randomized, bilateral, dispensing, parallel design study with two arms to evaluate contact lens related dry eye symptoms and subjective comfort.

Conditions: Visual Acuity
Phase: Not Applicable

Tafasitamab + Lenalidomide + R-CHOP Versus R-CHOP in Newly Diagnosed High-intermediate and High Risk DLBCL Patients

NCT04824092

This is a phase 3, multicenter, randomized, double-blind, placebo-controlled trial designed to compare the efficacy and safety of the humanized monoclonal anti CD19 antibody tafasitamab plus lenalidomide in addition to R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) versus R-CHOP in previously untreated, high-intermediate and high-risk patients with newly-diagnosed DLBCL

Conditions: Diffuse Large B-cell Lymphoma

CAM Procedure With BMAC for Shoulder OA

NCT04826224

Researchers want to find out more about the side effects of Bone Marrow Aspirate Concentrate (BMAC) and what doses of BMAC are safe for people.

Conditions: Shoulder Osteoarthritis