There are currently 852 clinical trials in Jacksonville, Florida looking for participants to engage in research studies. Trials are conducted at various facilities, including Mayo Clinic in Florida, Mayo Clinic - Jacksonville, Mayo Clinic and Mayo Clinic Florida. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Testing the Addition of the Chemotherapy Drug Lomustine (Gleostine®) to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed MGMT Methylated Glioblastoma
NCT05095376
Recruiting
This phase III trial compares the effect of adding lomustine to temozolomide and radiation therapy versus temozolomide and radiation therapy alone in shrinking or stabilizing newly diagnosed MGMT methylated glioblastoma. Chemotherapy drugs, such as lomustine and temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high energy photons to kill tumor cells and s... Read More
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
01/09/2024
Locations: Baptist MD Anderson Cancer Center, Jacksonville, Florida
Conditions: Glioblastoma, Gliosarcoma
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Testing the Addition of Whole Brain Radiotherapy Using a Technique That Avoids the Hippocampus to Stereotactic Radiosurgery in People With Cancer That Has Spread to the Brain and Come Back in Other Areas of the Brain After Earlier Stereotactic Radiosurgery
NCT04588246
Recruiting
This phase III trial compares the effect of adding whole brain radiotherapy with hippocampal avoidance and memantine to stereotactic radiosurgery versus stereotactic radiosurgery alone in treating patients with cancer that has spread to the brain and come back in other areas of the brain after earlier stereotactic radiosurgery. Hippocampus avoidance during whole-brain radiation therapy decreases the amount of radiation that is delivered to the hippocampus, which is a brain structure that is impo... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/09/2024
Locations: Mayo Clinic in Florida, Jacksonville, Florida
Conditions: Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma, Metastatic Digestive System Carcinoma, Metastatic Lung Non-Small Cell Carcinoma, Metastatic Malignant Neoplasm in the Brain, Metastatic Melanoma, Metastatic Renal Cell Carcinoma, Prognostic Stage IV Breast Cancer AJCC v8, Recurrent Brain Neoplasm, Stage IV Lung Cancer AJCC v8, Stage IV Renal Cell Cancer AJCC v8, Stage IVA Lung Cancer AJCC v8, Stage IVB Lung Cancer AJCC v8
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NKTR-255 vs Placebo Following CD19-directed CAR-T Therapy in Patients With Relapsed/Refractory Large B-cell Lymphoma
NCT05664217
Recruiting
This study will evaluate the safety and efficacy of NKTR-255 following CD19-directed chimeric antigen (CAR)-T cell therapy in patients with relapsed or refractory (R/R) large B-cell lymphoma (LBCL). NKTR-255 is an investigational IL-15 receptor agonist designed to boost the immune system's natural ability to fight cancer. T cells are infection fighting blood cells that can kill tumor cells. Chimeric antigen (CAR)-T cell product consists of genetically engineered T-cells, modified to recognize C... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/05/2024
Locations: Mayo Clinic Jacksonville, Jacksonville, Florida
Conditions: Non-Hodgkin Lymphoma, Relapsed/Refractory Diffuse Large B-cell Lymphoma
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Comparison of 24-hours Versus 72-hours of Octreotide Infusion in Preventing Early Rebleed From Esophageal Varices
NCT03624517
Recruiting
This study evaluates the safety and efficacy of 24-hour vs 72-hour octreotide infusion after variceal banding in cirrhotic patients with bleeding esophageal varices.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/05/2024
Locations: University of Florida Health, Jacksonville, Florida
Conditions: Esophageal Varices, Liver Cirrhoses, Bleeding Esophageal Varices, Upper Gastrointestinal Bleeding
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ONC-392 and Pembrolizumab in Platinum Resistant Ovarian Cancer
NCT05446298
Recruiting
This is a study to test the safety and efficacy with the combination of a next generation anti-CTLA-4 antibody, ONC-392, and anti-PD-1 antibody, pembrolizumab, in platinum resistant ovarian cancer patients.
Gender:
Female
Ages:
18 years and above
Trial Updated:
01/05/2024
Locations: Baptist MD Anderson Cancer Center, 404, Jacksonville, Florida
Conditions: Ovarian Cancer, High Grade Serous Adenocarcinoma of Ovary, Primary Peritoneal Carcinoma, Fallopian Tube Cancer
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A Study to Evaluate EDP 938 Regimens in Children With RSV
NCT04816721
Recruiting
A 2-part study to evaluate the safety, pharmacokinetics and efficacy of EDP-938 in children with RSV infection.
Gender:
All
Ages:
Between 28 days and 36 months
Trial Updated:
01/04/2024
Locations: University of Florida Health, Jacksonville, Florida
Conditions: Respiratory Syncytial Virus (RSV)
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A Safety/Tolerability and PK Study With Azstarys® in Children With ADHD
NCT05721235
Recruiting
The is a multicenter, dose-optimized, open-label, safety/ tolerability and pharmacokinetic (PK) study with Azstarys® in children 4 and 5 years of age with attention-deficit/hyperactivity disorder (ADHD). The primary objective is to determine the safety and tolerability of treating children 4 and 5 years-of-age with ADHD with Azstarys® for up 12 months. Approximately 100 subjects will be enrolled. Approximately 20 sites will participate.
Gender:
All
Ages:
Between 4 years and 5 years
Trial Updated:
01/04/2024
Locations: Clinical Neuroscience Solutions - Orlando, Jacksonville, Florida
Conditions: Attention Deficit/Hyperactivity Disorder
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TJ-68 Clinical Trial in Patients With Amyotrophic Lateral Sclerosis (ALS) and Muscle Cramps
NCT04998305
Recruiting
The primary objective of the study is to demonstrate the safety and potential efficacy of TJ-68 for improving muscle cramps in participants with ALS based on a two-site, randomized, placebo-controlled double-blind multi-period crossover (N-of-1) study design.
Gender:
All
Ages:
Between 20 years and 84 years
Trial Updated:
01/03/2024
Locations: Mayo Clinic, Jacksonville, Florida
Conditions: Amyotrophic Lateral Sclerosis, Muscle Cramp
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BioFLO for Respiratory Recovery in SCI
NCT06011876
Recruiting
Acute intermittent hypoxia (AIH) involves brief (1 min), repeated episodes (~15) of breathing low oxygen air to stimulate spinal neuroplasticity. Animal and human studies show that AIH improves motor function after spinal cord injury, particularly with slightly increased carbon dioxide (hypercapnic AIH; AIHH) and task-specific training. Using a double blind cross-over design, the study will test whether AIHH improves breathing more than AIH and whether specific genetic variations are related to... Read More
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
01/02/2024
Locations: Brooks Rehabilitation, Jacksonville, Florida
Conditions: Spinal Cord Injuries
Register for Updates
A Comparative Clinical Study to Determine the Optimal Initial Therapy for Multiple Myeloma
NCT06151717
Recruiting
This study evaluates the outcomes of patients undergoing initial therapy for multiple myeloma.
Gender:
All
Ages:
All
Trial Updated:
12/29/2023
Locations: Mayo Clinic in Florida, Jacksonville, Florida
Conditions: Multiple Myeloma
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Enfortumab Vedotin for the Treatment of Patients With Metastatic or Unresectable Squamous Cell Carcinoma of the Penis
NCT06104618
Recruiting
This phase II trial tests how well enfortumab vedotin works for treating patients with squamous cell carcinoma of the penis that has spread to other places in the body (metastatic) or cannot be removed by surgery (unresectable). Enfortumab vedotin is a monoclonal antibody, enfortumab, linked to an anticancer drug called vedotin. It works by helping the immune system to slow or stop the growth of tumor cells. Enfortumab attaches to a protein called nectin-4 on tumor cells in a targeted way and de... Read More
Gender:
Male
Ages:
18 years and above
Trial Updated:
12/21/2023
Locations: Mayo Clinic in Florida, Jacksonville, Florida
Conditions: Metastatic Penile Squamous Cell Carcinoma, Stage III Penile Cancer AJCC v8, Stage IV Penile Cancer AJCC v8, Unresectable Penile Squamous Cell Carcinoma
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HostDx Sepsis in the Diagnosis and Prognosis of Emergency Department Patients With Suspected Infections and Suspected Sepsis
NCT04094818
Recruiting
This study will analyze gene expression and other laboratory data from biological samples collected from participants with suspected respiratory, urinary, intra-abdominal, and/or skin & soft tissue infections; or suspected sepsis of any cause.
Gender:
All
Ages:
18 years and above
Trial Updated:
12/21/2023
Locations: University of Florida (UF) - Jacksonville, Jacksonville, Florida
Conditions: Respiratory Tract Infections, Urinary Tract Infections, Intra-Abdominal Infections, Skin and Soft Tissue Infection, Sepsis, Suspected Meningitis/Encephalitis or Any Other Infection
Register for Updates