The city of Orlando, Florida, currently has 9 active clinical trials seeking participants for Healthy research studies.
Study of an Investigational Pentavalent Meningococcal ABCYW Vaccine in Adults and Adolescents
Recruiting
The purpose of VAN00010 study is to assess the safety and immunogenicity of the investigational pentavalent meningococcal ABCYW vaccine in adults and adolescents. The study duration will be up to 12 months for all participants.
Gender:
All
Ages:
Between 10 years and 25 years
Trial Updated:
06/17/2024
Locations: Accel Research - Nona Pediatric Center Site Number : 8400079, Orlando, Florida
Conditions: Meningococcal Infection, Healthy Volunteers, Meningococcal Immunisation
A Study to Assess the Drug Levels of Repotrectinib in Healthy Participants and Participants With Moderate and Severe Hepatic Impairment
Recruiting
The purpose of this study is to assess the drug levels of a single oral dose of repotrectinib in participants with moderate and severe HI, and in healthy matched control participants with normal hepatic function.
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
06/12/2024
Locations: Local Institution - 0005, Orlando, Florida +1 locations
Conditions: Hepatic Impairment, Healthy Volunteers
A Study to Test How Avenciguat (BI 685509) is Taken up in the Body of People With and Without Liver Problems
Recruiting
This study is open to people with and without severe liver problems. People can join the study if they are 18 to 80 years of age and have a body mass index (BMI) between 18.5 and 42 kg/m2. Avenciguat (BI 685509) is a medicine that is being developed to treat high blood pressure in the portal vein (main vessel going to the liver). The purpose of this study is to find out whether having liver problems influences how Avenciguat (BI 685509) is taken up in the body. All participants take Avenciguat... Read More
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
04/30/2024
Locations: Orlando Clinical Research Center, Orlando, Florida
Conditions: Healthy, Liver Diseases
Study of Bemnifosbuvir in Subjects With Normal and Impaired Hepatic Function
Recruiting
To Assess the Effect of Hepatic Impairment on the Pharmacokinetics of Bemnifosbuvir After a Single Dose
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
02/01/2024
Locations: Atea Study Site Orlando Clinical Research Center, Orlando, Florida
Conditions: Healthy Volunteer, Hepatic Impairment
A Study of LY3502970 in Participants With Impaired and Normal Liver Function
Recruiting
The main purpose of this study is to measure how much of LY3502970 gets into the bloodstream and how long it takes the body to eliminate it in participants with mild, moderate and severe impaired liver function compared to participants with normal liver function. The safety and tolerability of LY3502970 will also be evaluated. The study may last up to 6 weeks for each participant including the screening period.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
01/29/2024
Locations: Orlando Clinical Research Center, Orlando, Florida
Conditions: Healthy, Hepatic Insufficiency
A Study of TAK-279 in Adults With or Without Liver Damage
Recruiting
The main aim of this study is to find out how the body processes 1 dose of TAK-279 (pharmacokinetics) in participants with liver problems compared to participants without liver problems. Other aims are to check for side effects from TAK-279 and to learn how well participants tolerate 1 dose of TAK-279. The participants will need to stay at the clinic for 11 days.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/21/2023
Locations: Orlando Clinical Research Center, Orlando, Florida
Conditions: Hepatic Impairment, Healthy Volunteers
Tumor-Derived FGF19
Recruiting
Identify and test thresholds, specificity and sensitivity for a potential cancer associated biomarker protein, FGF19, (and associated markers) for detection in human blood in the blood of breast and colorectal in cancer patients, and see if occurs at higher rates than healthy controls
Gender:
All
Ages:
18 years and above
Trial Updated:
10/09/2023
Locations: Burnett School Biomedical Sciences, Orlando, Florida
Conditions: Colorectal Cancer, Breast Cancer, Healthy
Blood Collection for COM/BSBS
Recruiting
The objective of this biospecimen collection protocol is the acquisition of blood from adult volunteers. These biospecimens will be transferred to the College of Medicine (COM)/Burnett School of Biomedical Sciences (BSBS) research scientists and their research teams for testing according to their separate IRB-approved/exempted protocols. These separate IRBapproved protocols cannot be for genetic testing.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/08/2023
Locations: University of Central Florida, Orlando, Florida
Conditions: Healthy
Study of ALXN2050 in Participants With Hepatic Impairment
Recruiting
This study will investigate the impact of impaired hepatic function (IHF) on the plasma pharmacokinetics of ALXN2050 in order to provide dosing recommendations for future indications in individuals with varying degrees of IHF.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
06/22/2023
Locations: Clinical Trial Site, Orlando, Florida
Conditions: Impaired Hepatic Function, Healthy