There are currently 1574 clinical trials in Baltimore, Maryland looking for participants to engage in research studies. Trials are conducted at various facilities, including Johns Hopkins University, Johns Hopkins Hospital, University of Maryland and Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Perioperative Gemcitabine, Cisplatin, and Pembrolizumab in Potentially Resectable Biliary Tract Cancers
Recruiting
The purpose of this study is to determine the safety of peri-operative gemcitabine, cisplatin, and pembrolizumab in patients with BTC, as well as whether the combination of gemcitabine, cisplatin, and pembrolizumab (gem/cis/pembro) is feasible and lead to pathologic responses.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/24/2024
Locations: SKCCC Johns Hopkins, Baltimore, Maryland
Conditions: Pancreatic Cancer
Exploration of Personalized Biomarkers During Neoadjuvant Radiation Therapy for Spinal and Sacral Chordoma
Recruiting
In this study the investigators will study the effects of neoadjuvant radiation therapy (RT), in the form of either proton therapy or stereotactic body radiation therapy (SBRT), on the Circulating tumor DNA (ctDNA), radiographic changes and radiomics, and the validity of these findings will be compared using the current gold standard- pathologic findings. The purpose of this work is to explore whether the biomarkers may be used diagnostically to better understand radiographic changes following R... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/24/2024
Locations: Johns Hopkins Hospital, Baltimore, Maryland
Conditions: Chordoma of Spine, Chordoma of Skull Base, Chordoma of Sacrum
Investigation on the Bidirectional Cortical Neuroprosthetic System
Recruiting
The Bidirectional Cortical Neuroprosthetic System (BiCNS) consists of NeuroPort Microelectrode Array Systems and NeuroPort Electrodes (Sputtered Iridium Oxide Film), Patient Pedestals, the NeuroPort BioPotential Signal Processing System, and the CereStim C96 Programmable Stimulator. The goals of this early feasibility study consist of safety and efficacy evaluations of this device.
Gender:
ALL
Ages:
Between 22 years and 65 years
Trial Updated:
07/24/2024
Locations: Department of Neurology, Baltimore, Maryland
Conditions: Tetraplegia, Quadriplegia
Substance Checking Outreach and Pre-Exposure Prophylaxis (PrEP) Engagement Study
Recruiting
Through the proposed Substance Checking Outreach and Pre-Exposure Prophylaxis (PrEP) Engagement (SCOPE) study, the investigators will design and evaluate an overdose prevention and HIV prevention study among people who use drugs (PWUD). Specifically, SCOPE will provide access to drug-checking services for PWUD to better understand the contents of the drug supply, in combination with PrEP for those who are HIV-, to both reduce overdose and HIV among PWUD in Baltimore City.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/22/2024
Locations: Johns Hopkins School of Public Health, Baltimore, Maryland
Conditions: HIV Infections
Remote Monitoring in Progressive Supranuclear Palsy (PSP)
Recruiting
This is a single-arm, longitudinal, observational study on the use of wearable sensors and digital health technology to measure fall frequency and motor, speech, and cognitive function in patients with PSP over the course of approximately one year. Participants will perform supervised remote assessments monthly and in-person assessments approximately every 6 months.
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
07/22/2024
Locations: Johns Hopkins, Baltimore, Maryland
Conditions: Progressive Supranuclear Palsy, Parkinson Disease, MSA - Multiple System Atrophy
An Engineering-Based Balance Assessment and Training Platform
Recruiting
This is a proposal to develop a Balanced Reach Training Protocol (BRTP) to evaluate and train dynamic standing balance. The BRTP is based upon the Balanced Reach Test (BRT) that the investigators previously developed and validated. In the BRT subjects stand and point to a target disk moving unpredictably across a large projection screen in front of them without stepping. Body movements undertaken to track the disk are integral to many daily activities and represent an important class of "expecte... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
07/19/2024
Locations: Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD, Baltimore, Maryland
Conditions: Balance Deficits, Stroke
Utility of Hyperpolarized 13C-pyruvate Metabolic Magnetic Resonance Imaging
Recruiting
This is a two-tiered pilot study in which there will be no randomization and no placebo treatment. This study will be to perform metabolic magnetic resonance imaging on men suspected to have a prostate cancer to understand if metabolic MRI can be safely performed on this population
Gender:
MALE
Ages:
Between 40 years and 80 years
Trial Updated:
07/18/2024
Locations: University of Maryland Medical Center, Baltimore, Maryland
Conditions: Prostate Cancer
Hyperpolarized 13C-pyruvate Metabolic MRI With Infiltrating Gliomas
Recruiting
The purpose of this study is to examine the safety and feasibility of performing hyperpolarized metabolic MRI in the diagnosis of brain tumor. This study will also assess the accuracy of hyperpolarized metabolic MRI to diagnose intermediate to patients with infiltrating gliomas and examine the added utility of metabolic MRI over standard MRI imaging The FDA is allowing the use of hyperpolarized \[1-13C\] pyruvate (HP 13C-pyruvate) in this study. Up to 5 patients may take part in this study at... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
07/18/2024
Locations: Rosy Njonkou Tchoquessi, Baltimore, Maryland
Conditions: Glioma
Trial of CORT108297 to Attenuate the Effects of Acute Stress in the Allocortex (CORT-X)
Recruiting
CORT-X will examine if mitigation of stress-mediated pathogenesis of Alzheimer's disease (AD) is a feasible target for intervention in individuals at risk for this disease. This single-site (Baltimore, Maryland) phase II clinical trial is a 2-week, randomized, placebo-controlled crossover study of the effects of the selective glucocorticoid receptor antagonist, CORT108297, on cognitive test performance in 26 individuals with mild cognitive impairment (MCI) due to AD and in 26 cognitively normal... Read More
Gender:
ALL
Ages:
55 years and above
Trial Updated:
07/17/2024
Locations: Johns Hopkins School of Medicine, Baltimore, Maryland
Conditions: Mild Cognitive Impairment, Alzheimer Disease, Memory Impairment
Resiliency in U.S. Air Force Personnel
Recruiting
The goal of this clinical trial is to examine the effectiveness of the Stress Management and Resilience Training (SMART) in increasing resilience in a population of U.S. Air Force personnel at Joint Base Andrews, Joint Base San Antonio-Lackland, Nellis Air Force Base, and Wright-Patterson Air Force Base. The main questions it aims to answer are: 1. When delivered in real-world conditions, to what extent does SMART increase levels of resiliency and decrease levels of stress in a sample of activ... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/17/2024
Locations: Johns Hopkins University, School of Nursing (Joint Base Andrews), Baltimore, Maryland
Conditions: Stress, Quality, Anxiety, Resilience
Pancreatic Cancer Registry: For Any Person With a Personal or Family History
Recruiting
The NFPTR was established in 1994 to find the causes of pancreatic cancer. In brief, the investigators are interested in both the genetic and non-genetic causes of pancreatic cancer. The investigators are particularly interested in finding the genes that cause pancreatic cancer to cluster in some families. Up to 10% of pancreatic cancer patients have another close relative who has also developed pancreatic cancer. This clustering of pancreatic cancers in families has yet to be explained; however... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/16/2024
Locations: Johns Hopkins Hospital, Baltimore, Maryland
Conditions: Pancreatic Cancer, ATM, BRCA, Hereditary Cancer
Behavioral Weight Loss for Cancer Survivors in Maryland: A Trial With Adaptive Interventions
Recruiting
The objective of the HELPLINE Weight Loss Program is to determine the comparative effectiveness of two active multi-component, augmented interventions for cancer survivors with overweight or obesity who do not achieve early weight loss goal in the initial intervention period (termed, early non-responders). The core study design is randomized controlled trial with adaptive intervention. 1. CORE Helpline in all participants (first 2 months) 2. Extended Helpline in early responders (additional 6 m... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/16/2024
Locations: Johns Hopkins ProHealth, Baltimore, Maryland
Conditions: Weight Loss