There are currently 1519 clinical trials in Baltimore, Maryland looking for participants to engage in research studies. Trials are conducted at various facilities, including Johns Hopkins University, Johns Hopkins Hospital, University of Maryland and Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Left Ventricular Structural Predictors of Sudden Cardiac Death
NCT01076660
Recruiting
Sudden cardiac death (SCD) poses a significant health care challenge with high annual incidence and low survival rates. Implantable cardioverter defibrillators (ICDs) prevent SCD in patients with poor heart function. However, the critical survival benefit afforded by the devices is accompanied by short and long-term complications and a high economic burden. Moreover, in using current practice guidelines of reduced heart function, specifically left ventricular ejection fraction (LVEF)≤35%, as the... Read More
Gender:
ALL
Ages:
Between 21 years and 80 years
Trial Updated:
01/10/2025
Locations: Johns Hopkins Medical Institutions, Baltimore, Maryland
Conditions: Ischemic Cardiomyopathy, Nonischemic Cardiomyopathy
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Imaging Techniques for Identifying Factors of Sudden Cardiac Death Risk
NCT00181233
Recruiting
Sudden cardiac death is a tragic event that strikes all age groups and is unfortunately increasing in prevalence. Because it is difficult to predict those at highest risk, this study is designed to test the hypothesis that new imaging techniques (magnetic resonance imaging \[MRI\] and computed tomography \[CT\]) are useful for identifying factors which put people at high risk for sudden death.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/09/2025
Locations: Johns Hopkins Medical Institutions, Baltimore, Maryland
Conditions: Sudden Cardiac Death
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Image-guided Focal Brachytherapy Utilizing Combined 18F-DCFPyl PET/CT
NCT03861676
Recruiting
The Principal Investigator's (PI) working hypothesis is that the PI can utilize the high predictive value of 18F-DCFPyl PSMA to identify clinically significant tumors in patients who will undergo brachytherapy, as well as areas which are uninvolved or contain only clinically insignificant disease. In the PI's clinical trial, the uninvolved regions (as defined by combined PET-MR-biopsy data) will not be targeted and receive only fall-off dose, which we have shown to be associated with reductions... Read More
Gender:
MALE
Ages:
Between 18 years and 100 years
Trial Updated:
01/09/2025
Locations: SKCCC at Johns Hopkins, Baltimore, Maryland
Conditions: Prostate Cancer
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T-DM1 and Tucatinib Compared with T-DM1 Alone in Preventing Relapses in People with High Risk HER2-Positive Breast Cancer, the CompassHER2 RD Trial
NCT04457596
Recruiting
This phase III trial studies how well trastuzumab emtansine (T-DM1) and tucatinib work in preventing breast cancer from coming back (relapsing) in patients with high risk, HER2 positive breast cancer. T-DM1 is a monoclonal antibody, called trastuzumab, linked to a chemotherapy drug, called DM1. Trastuzumab is a form of targeted therapy because it attaches to specific molecules (receptors) on the surface of cancer cells, known as HER2 receptors, and delivers DM1 to kill them. Tucatinib may stop t... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/09/2025
Locations: Greater Baltimore Medical Center, Baltimore, Maryland +5 locations
Conditions: Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIA Breast Cancer AJCC v8, Anatomic Stage IIB Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8, Anatomic Stage IIIB Breast Cancer AJCC v8, Anatomic Stage IIIC Breast Cancer AJCC v8, HER2 Positive Breast Carcinoma, Invasive Breast Carcinoma, Multifocal Breast Carcinoma, Prognostic Stage I Breast Cancer AJCC v8, Prognostic Stage IA Breast Cancer AJCC v8, Prognostic Stage IB Breast Cancer AJCC v8, Prognostic Stage II Breast Cancer AJCC v8, Prognostic Stage IIA Breast Cancer AJCC v8, Prognostic Stage IIB Breast Cancer AJCC v8, Prognostic Stage III Breast Cancer AJCC v8, Prognostic Stage IIIA Breast Cancer AJCC v8, Prognostic Stage IIIB Breast Cancer AJCC v8, Prognostic Stage IIIC Breast Cancer AJCC v8, Synchronous Bilateral Breast Carcinoma
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Study of INBRX-109 in Conventional Chondrosarcoma
NCT04950075
Recruiting
Randomized, blinded, placebo-controlled, Phase 2 study of INBRX-109 in unresectable or metastatic conventional chondrosarcoma patients.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
01/09/2025
Locations: Johns Hopkins, Baltimore, Maryland
Conditions: Conventional Chondrosarcoma
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Scrambler Therapy for Post-Stroke Pain
NCT05563038
Recruiting
The Investigators will enroll patients who have had a stroke and are experiencing post-stroke pain secondary to their infarct and disruption of the sensory system in a research study to compare the effectiveness of Scrambler Therapy to traditional pharmacologic therapies.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/09/2025
Locations: Johns Hopkins Bayview Hospital, Baltimore, Maryland
Conditions: Post Stroke Pain
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Gender Related Coping and Survivorship for Genitourinary Cancers
NCT05649306
Recruiting
This research is being done to learn more about coping and survivorship of women with bladder cancer, specifically regarding psychosocial distress and sexual dysfunction. This study is a non-therapeutic study and will randomize participants to a standard of care group and education group. Patients in both groups will be asked to complete surveys regarding their mood and sexual function. Patients in the intervention group will be asked to complete attendance diaries regarding educational and supp... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
01/09/2025
Locations: Johns Hopkins Hospital, Baltimore, Maryland
Conditions: Bladder Cancer
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Outcomes of High-risk Non-muscle Invasive Bladder Cancer Treated With Blue Light Resection
NCT06525571
Recruiting
Comparing white-light cystoscopy (WLC) and blue-light cystoscopy (BLC) in TURBT for high risk (HR) non-muscle invasive bladder cancer (NMIBC) patients is crucial to determine the most effective method for reducing residual disease burden and improving recurrence-free survival. Enhanced visualization with BLC may lead to more accurate resections, potentially decreasing recurrence rates and improving long-term outcomes for bladder cancer patients. Patients will be randomized to either WLC TURBT or... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/09/2025
Locations: Johns Hopkins University School of Medicine, Baltimore, Maryland
Conditions: Bladder Cancer
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Ketamine for Multiple Sclerosis Fatigue
NCT05378100
Recruiting
The proposed study is a single-center, phase II, randomized, double-blind, parallel-group, active-placebo-controlled trial of intravenous low-dose ketamine in patients with MS fatigue.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
01/08/2025
Locations: Johns Hopkins University, Baltimore, Maryland
Conditions: Multiple Sclerosis Fatigue
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QST Study: Predicting Treatment Response in Chronic Pancreatitis Using Quantitative Sensory Testing
NCT03434392
Recruiting
Quantitative Sensory Testing (QST) is a novel investigative technique used in other pain conditions to evaluate patterns of chronic pain, and in this study will be used to elucidate pain patterns in patients with Chronic Pancreatitis (CP). QST uses a specific series of standardized stimulations to map the pain system. QST has the potential to change and improve the treatment paradigm for patients with CP and may eventually be able to predict response to invasive CP therapies.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/07/2025
Locations: Johns Hopkins Medical Institutions, Baltimore, Maryland
Conditions: Chronic Pancreatitis, Chronic Pain
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Pancreatic Quantitative Sensory Testing (P-QST) to Predict Treatment Response for Pain in Chronic Pancreatitis
NCT04996628
Recruiting
Abdominal pain in chronic pancreatitis (CP) affects up to 90% of patients during the course of their disease, and response to currently available therapies is suboptimal and unpredictable. The proposed clinical trial will evaluate the predictive capability of Pancreatic Quantitative Sensory Testing (P-QST) - a novel assessment of neurosensory phenotyping- for improvement in pain in patients with CP who are undergoing medically-indicated invasive treatment with endoscopic therapy or surgery.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/07/2025
Locations: Johns Hopkins Medical Institutions, Baltimore, Maryland
Conditions: Chronic Pancreatitis, Chronic Pain
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Minimizing ICU Neurological Dysfunction With Dexmedetomidine-induced Sleep (MINDDS II)
NCT06192615
Recruiting
This is a pragmatic phase III, randomized, blinded, double placebo-controlled, three-arm trial of elderly patients following cardiac surgery to assess the relationship between nighttime intravenous (IV) and sublingual dexmedetomidine on postoperative delirium and functional outcomes after surgery.
Gender:
ALL
Ages:
60 years and above
Trial Updated:
01/06/2025
Locations: University of Maryland School of Medicine, Baltimore, Maryland
Conditions: Delirium
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