There are currently 2667 clinical trials in Boston, Massachusetts looking for participants to engage in research studies. Trials are conducted at various facilities, including Massachusetts General Hospital, Dana Farber Cancer Institute, Beth Israel Deaconess Medical Center and Brigham and Women's Hospital. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
BEACON: A Study Evaluating the Safety and Efficacy of BEAM-101 in Patients With Severe Sickle Cell Disease
NCT05456880
Recruiting
This is an open-label, single-arm, multicenter, Phase 1/2 study evaluating the safety and efficacy of the administration of autologous base edited CD34+ HSPCs (BEAM-101) in patients with severe SCD
Gender:
ALL
Ages:
Between 18 years and 35 years
Trial Updated:
01/09/2025
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Sickle Cell Disease
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A Study of FF-10850 Topotecan Liposome Injection in Advanced Solid Tumors Including Merkel Cell Carcinoma
NCT04047251
Recruiting
To determine the safety profile, maximum tolerated dose (MTD), dose-limiting toxicities (DLTs), and recommended Phase 2 dose (RP2D) of FF-10850 (topotecan liposome injection) in patients with advanced solid tumors including Merkel Cell Carcinoma
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/09/2025
Locations: Dana Farber Cancer Institute (DFCI), Boston, Massachusetts
Conditions: Advanced Solid Tumors, Merkel Cell Carcinoma
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Natural History Study of Patients With Canavan Disease (CANinform Study)
NCT04126005
Recruiting
This study uses medical records that allow retrospective data extraction of critical milestone and motor function data. In addition, prospective assessments collect data relevant to the natural history of Canavan disease in children.
Gender:
ALL
Ages:
All
Trial Updated:
01/09/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Canavan Disease
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Venetoclax in Combination With Intensive Induction and Consolidation Chemotherapy in Treatment Naïve AML
NCT03709758
Recruiting
This research study is studying the combination of venetoclax and chemotherapy as a possible treatment for acute myelogenous leukemia (AML). The drugs involved in this study are: * Venetoclax * Daunorubicin * Cytarabine
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
01/09/2025
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: Acute Myeloid Leukemia
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Study to Determine Optimal Dose and Evaluate Safety, Tolerability, and Pharmacokinetics of Progerinin in Patients with Hutchinson-Gilford Progeria Syndrome (HGPS)
NCT06775041
Recruiting
Researchers will compare treatment with progerinin plus lonafarnib vs lonafarnib alone to assess optimal dosing, safety, tolerability, and pharmacokinetics in patients with Hutchinson-Gilford Progeria Syndrome (HGPS). Subjects in the randomized study arms will continue to take the standard of care (SOC), lonafarnib, and will be randomized to either take SOC alone or in combination with progerinin.
Gender:
ALL
Ages:
1 year and above
Trial Updated:
01/09/2025
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Hutchinson-Gilford Progeria Syndrome
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Study of INBRX-109 in Conventional Chondrosarcoma
NCT04950075
Recruiting
Randomized, blinded, placebo-controlled, Phase 2 study of INBRX-109 in unresectable or metastatic conventional chondrosarcoma patients.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
01/09/2025
Locations: Dana Farber Cancer Institute, Boston, Massachusetts +1 locations
Conditions: Conventional Chondrosarcoma
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FUVID Study: Functional Characterization of Children With Chronic Venous Thromboembolic Disease
NCT04583878
Recruiting
This is a multi-center prospective cohort study of patients with first-episode deep venous thrombosis and pulmonary embolism.
Gender:
ALL
Ages:
Between 8 years and 21 years
Trial Updated:
01/09/2025
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Deep Venous Thrombosis, Pulmonary Embolism
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Savolitinib Plus Osimertinib Versus Platinum-based Doublet Chemotherapy in Participants With Non-Small Cell Lung Cancer Who Have Progressed on Osimertinib Treatment
NCT05261399
Recruiting
Clinical study to investigate the efficacy and safety of savolitinib in combination with osimertinib versus platinum-based doublet chemotherapy in participants with EGFR mutated, MET-overexpressed and/or amplified, locally advanced or metastatic NSCLC who have progressed on treatment with Osimertinib.
Gender:
ALL
Ages:
Between 18 years and 130 years
Trial Updated:
01/09/2025
Locations: Research Site, Boston, Massachusetts +1 locations
Conditions: Carcinoma, Non-Small-Cell Lung
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Phase I/II Study of SKG0106 Intravitreal Injection in Patients With Neovascular Age-related Macular Degeneration (nAMD)
NCT05986864
Recruiting
This is a phase 1/2 clinical study to evaluate the safety, preliminary efficacy, immunogenicity, and pharmacokinetic (PK) characteristics of SKG0106 in subjects with nAMD. Based on results from the phase 1 dose escalation study, the phase 2 expansion study will be conducted.
Gender:
ALL
Ages:
50 years and above
Trial Updated:
01/08/2025
Locations: Ophthalmic Consultants of Boston, Boston, Massachusetts
Conditions: Neovascular Age-related Macular Degeneration
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Evaluation of Pro-Inflammatory Leukocyte Activity in Patients Undergoing Cardiac Surgery
NCT04299828
Recruiting
The goal of this proposal is to prospectively collect data from a series of 100 patients (all ages) undergoing complex cardiac surgical procedures involving cardiopulmonary bypass (CPB) to: 1. Measure the number of blood activated circulating monocytes before, during and after cardiac surgery and serum GABA and pro-inflammatory cytokine levels 2. Understand the correlation between GABA and inflammatory cytokines (and/or activated monocytes) and 3. Assess the correlation between thrombosis and m... Read More
Gender:
ALL
Ages:
All
Trial Updated:
01/08/2025
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Congenital Heart Disease, Coagulation
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Validation of a Novel Cerebellar-striatal Satiety Circuit in Humans
NCT06105164
Recruiting
This study uses a noninvasive technique called transcranial magnetic stimulation (TMS) to study satiety in healthy individuals. TMS is a noninvasive way of stimulating the brain, using a magnetic field to change activity in the brain. The magnetic field is produced by a coil that is held next to the scalp. In this study, the investigators will be stimulating the brain to learn more about the role of the cerebellum in satiety.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
01/08/2025
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Appetitive Behavior, Obesity
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Non-invasive Point-Of-Care Hemoglobin Testing In An Obstetric Population
NCT06521840
Recruiting
Anemia is common during pregnancy due to increased metabolic rate and normal physiologic changes associated with pregnancy. Anemia during pregnancy has been associated with increased of adverse outcomes during delivery and the postpartum period. Currently, it is recommended to screen for anemia at three pre-specified points during routine prenatal care, typically 3 months apart. This screening method may miss patients who develop anemia between these intervals and lead to a delay in diagnosis an... Read More
Gender:
FEMALE
Ages:
Between 18 years and 60 years
Trial Updated:
01/08/2025
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Pregnancy Anemia
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