There are currently 2781 clinical trials in Boston, Massachusetts looking for participants to engage in research studies. Trials are conducted at various facilities, including Massachusetts General Hospital, Dana Farber Cancer Institute, Beth Israel Deaconess Medical Center and Brigham and Women's Hospital. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Lung-Resident Memory Th2 Cells in Asthma
NCT03455959
Recruiting
Determining how memory T helper type 2 (Th2) initiate recall responses to aeroallergens has the potential to change the therapeutic approach to allergic asthma, the most common asthma subtype. ~5-10% of effector Th2 cells recruited into the lung give rise to long-lived tissue resident memory cells that are poised to respond upon allergen re-exposure.Consequently, targeting memory Th2 cell activation is an attractive therapeutic strategy. However, it is not well understood how allergen inhalation... Read More
Gender:
All
Ages:
Between 18 years and 55 years
Trial Updated:
09/06/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Asthma, Allergic
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Neuroimaging Sleep and Mood in Depression
NCT05497414
Recruiting
This study will investigate how sleep and mood are related in patients with depression and in healthy controls. It will use MRI-based measures of brain function to determine how neural systems are modulated by sleep and sleep deprivation, and its links to mood in depression.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
08/26/2022
Locations: Boston University, Boston, Massachusetts
Conditions: Major Depression
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Postoperative Pain Control Using Local Wound Infiltration in Adolescent Idiopathic Surgery
NCT04730531
Recruiting
Non-opioid methods of pain management following posterior spinal fusion (PSF) have become increasingly popular given the rise of opioid abuse and opioid-related deaths. Orthopedic surgery remains one of the highest prescribing subspecialties. Local wound infiltration is an effective method of acute pain management following surgical intervention and is the standard in some surgical subspecialties, however, no randomized control trials (RCT) exist in the pediatric spine literature. This would be... Read More
Gender:
All
Ages:
Between 10 years and 17 years
Trial Updated:
08/23/2022
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Postoperative Pain, Spinal Fusion
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FOLFIRINOX + NIS793 in Pancreatic Cancer
NCT05417386
Recruiting
This research is being done to evaluate the safety and effectiveness of the drug NIS793 in combination with the standard of care treatment FOLFIRINOX (consists of the drugs 5-Fluorouracil (5-FU), Oxaliplatin, Irinotecan, and Leucovorin), chemoradiation and surgery for people with metastatic pancreas adenocarcinoma. The drugs involved in this study are: NIS793 FOLFIRINOX (consists of the drugs 5-Fluorouracil (5-FU), Oxaliplatin, Irinotecan, and Leucovorin) Other interventions include chemorad... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
08/19/2022
Locations: Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Conditions: Pancreas Cancer, Metastatic Pancreatic Cancer, Metastatic Pancreatic Adenocarcinoma
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Effect of Using Placental Membranes on Healing and Post-op Pain After Gum Surgery
NCT04957342
Recruiting
When harvesting autogenous free grafts to treat periodontal conditions (e.g., lack of attached keratinized tissue, ridge defects, and other mucogingival deformities), the hard palate is the preferred donor site. The primary disadvantage of this technique is the creation of a second surgical site. This sacrificial traumatic lesion on the palate is associated with significant post-operative morbidities, including patient discomfort, infection, inflammation, hemorrhage, and necrosis. A pilot, blin... Read More
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
08/17/2022
Locations: Harvard School of Dental Medicine, Boston, Massachusetts
Conditions: Pain, Postoperative, Gingival Diseases
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Impact of a Patient-Centered Program for Low Anterior Resection Syndrome A Multicenter Randomized Controlled Trial
NCT03828318
Recruiting
After undergoing restorative proctectomy for rectal cancer, many patients are left with significant bowel dysfunction, known as Low Anterior Resection Syndrome (LARS). Increased LARS severity correlates with worse perceived global health status and quality of life (QoL). Among patients undergoing rectal resection with a permanent ostomy, there is evidence that supportive and educational interventions improve QoL, ostomy proficiency, self-efficacy and knowledge. However, evidence regarding the im... Read More
Gender:
All
Ages:
Between 18 years and 99 years
Trial Updated:
08/17/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Rectal Cancer, Surgery, Patient Activation, Low Anterior Resection, Low Anterior Resection Syndrome
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Neural Circuits for Action Perception
NCT05507320
Recruiting
Study the mechanisms underlying action recognition and execution
Gender:
All
Ages:
Between 14 years and 70 years
Trial Updated:
08/17/2022
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Epilepsy
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Pediatric Pulmonary Hypertension Network (PPHNet) Informatics Registry
NCT02249923
Recruiting
Patients are being asked to be in this research study because medical researchers hope that by gathering information about a large number of children with pulmonary hypertension over time, their understanding of the disease process will increase and lead to better treatment. Investigators believe that pulmonary hypertension in children is different than pulmonary hypertension in adults and this study will help us understand those differences.
Gender:
All
Ages:
Between 1 day and 21 years
Trial Updated:
08/10/2022
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Pulmonary Vascular Disease, Pulmonary Arterial Hypertension
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Diagnostic Accuracy and Safety of DBV1605 for the Diagnosis of Non-IgE Mediated Cow's Milk Allergy in Children
NCT04492683
Recruiting
Study to assess the diagnostic accuracy (sensitivity, specificity, positive and negative predictive value) of DBV1605 for the diagnosis of non-Immunoglobulin E (IgE) mediated cow's milk allergy (CMA) in children with symptoms suggestive of non-IgE mediated CMA.
Gender:
All
Ages:
Between 29 days and 24 months
Trial Updated:
08/09/2022
Locations: Massachusets General Hospital, Boston, Massachusetts
Conditions: Cow's Milk Allergy
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Thoracoabdominal Asynchrony and Respiratory Distress
NCT04626154
Recruiting
The investigators hypothesize that a simple 3-point tracking device that uses motion sensors attached to the abdomen and chest of a child will provide information regarding thoracoabdominal asynchrony (TAA), a major component of respiratory distress, and ultimately help guide a clinician to initiate, escalate, de-escalate, or stop respiratory support interventions. AIMS To determine if the TAA-monitoring device can be used to detect differences in respiratory synchrony in a manner that is clini... Read More
Gender:
All
Ages:
Between 28 days and 17 years
Trial Updated:
08/08/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Respiratory Insufficiency
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GaitBetter: Motor and Cognitive Training for Gait Rehabilitation and Falls Prevention in Stroke Survivors.
NCT04625127
Recruiting
In this research study, the investigators aim to test the usability and efficacy of the GaitBetter system for gait rehabilitation after stroke.
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
08/04/2022
Locations: Spaulding Rehabilitation Hospital Boston, Boston, Massachusetts
Conditions: Stroke, Gait, Hemiplegic, Hemiplegia
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Salivary Profiling in Infants Treated for Suspected Sepsis: The SPITSS Study
NCT05490212
Recruiting
The aim of this study is to develop a faster, safer, and more accurate method for determining if a newborn has an infection. This study involves analyzing saliva for markers of infection and inflammation known as cytokines. We will analyze infant's saliva repeatedly for inflammatory biomarkers (cytokines) within the first 36 hours of their standard of care treatment. We hypothesize that levels of these cytokines will more quickly predict which babies are truly infected and which babies are not c... Read More
Gender:
All
Ages:
All
Trial Updated:
08/04/2022
Locations: Tufts Medical Center, Boston, Massachusetts
Conditions: Infection; Newborn
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