There are currently 2700 clinical trials in Boston, Massachusetts looking for participants to engage in research studies. Trials are conducted at various facilities, including Massachusetts General Hospital, Dana Farber Cancer Institute, Brigham and Women's Hospital and Beth Israel Deaconess Medical Center. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Gene Expression Profiling in Subjects With Postoperative Atrial Fibrillation After Cardiac Surgery (GENEXPRO Surg)
NCT00833313
Recruiting
Atrial fibrillation is a type of irregular heartbeat that is common after having heart surgery. There may be many different reasons why some people get atrial fibrillation after their heart surgery. These reasons may include that a person is older or that he/she is taking certain types of medications before surgery. Genes may also be a reason. Genes contain the material passed from parent to child that determines the make-up of the body and mind. For example, some genes control the color of your... Read More
Gender:
ALL
Ages:
Between 20 years and 99 years
Trial Updated:
02/06/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Atrial Fibrillation
Register for Updates
Assessing the Burden of Perioperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery
NCT04880265
Recruiting
Background and Significance: In the United States approximately 220,000 patients undergo cardiac surgery per annum. Among potential complications, the incidence of atrial fibrillation (AF) is estimated at 30 - 60 %, and therefore presents the most common adverse event after cardiac surgery. Multiple complications may be associated with AF: Patients are usually subject to an increased length-of-stay in the intensive care unit and in the hospital. Furthermore, the risk for stroke and development... Read More
Gender:
ALL
Ages:
Between 20 years and 90 years
Trial Updated:
02/06/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Atrial Fibrillation, Cardiac Surgery
Register for Updates
Prospectively Collected Pleural Biopsies for Validation of Malignant Pleural Mesothelioma Prognostic Biomarkers
NCT03683680
Recruiting
This research study is evaluating a new method for determining stage and prognosis of individuals with malignant pleural mesothelioma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/23/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Mesothelioma
Register for Updates
Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk Patients With Depression
NCT05450432
Recruiting
The study will consist of a 24-week-long trial examining outcomes in patients with Major Depressive Disorder and suicidal ideation who will receive intravenous (IV) ketamine and intranasal (IN) esketamine, compared to a large sample of matched historical controls. Patients will be recruited from an inpatient psychiatric unit. Eligible patients who provided informed consent will be enrolled in the study that will include a eight IV ketamine treatments, 13 esketamine treatment visits, seven long a... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
01/20/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Major Depressive Disorder
Register for Updates
Transplantation of Autologously Derived Mitochondria Following Ischemia
NCT02851758
Recruiting
The investigators propose a robust therapeutic intervention to ameliorate myocardial ischemia/ reperfusion injury and significantly decrease morbidity and mortality in patients requiring extracorporeal membrane oxygenation (ECMO), by direct injection of autogeneic mitochondria into the ischemic myocardium.
Gender:
ALL
Ages:
17 years and below
Trial Updated:
01/09/2023
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Extracorporeal Membrane Oxygenation Complication
Register for Updates
Rett Syndrome Registry
NCT05432349
Recruiting
The Rett Syndrome Registry is a longitudinal observational study of individuals with MECP2 mutations and a diagnosis of Rett syndrome. Designed together with the IRSF Rett Syndrome Center of Excellence Network medical directors, this study collects data on the signs and symptoms of Rett syndrome as reported by the Rett syndrome experts and by the caregivers of individuals with Rett syndrome. This study will be used to develop consensus based guidelines for the care of your loved ones with Rett s... Read More
Gender:
ALL
Ages:
Between 0 years and 99 years
Trial Updated:
01/09/2023
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Rett Syndrome, Rett Syndrome, Atypical, Genetic Disease, Genetic Diseases, X-Linked, Intellectual Disability, Neurobehavioral Manifestations, Neurologic Manifestations, Neurologic Disorder, Neurodevelopmental Disorders, Nervous System Diseases
Register for Updates
RCT Study to Validate niPGT-A Clinical Benefit.
NCT04000152
Recruiting
Chromosomal aneuploidies are linked with spontaneous miscarriages and abnormal offspring in human pregnancies. In addition, some types of aneuploidies are reported to prevent implantation. Thus, there is a need to identify the embryos with highest implantation potential on in vitro fertilization (IVF) programs. Since embryo morphology and kinetics have a weak association with embryo ploidy, trophectoderm biopsy plus Next-Generation Sequencing (NGS) is becoming a very popular approach to determi... Read More
Gender:
FEMALE
Ages:
Between 20 years and 40 years
Trial Updated:
12/13/2022
Locations: Boston IVF Fertility Clinic, Boston, Massachusetts
Conditions: Aneuploidy, Chromosome Abnormality, Infertility
Register for Updates
First in Human Phase 1 Ascending Dose Study of PanChol in Healthy Volunteers
NCT05657782
Recruiting
This study is a first-in-human, Phase 1 study of the safety, tolerability, and immunogenicity of PanChol in healthy volunteers. There will be three modules in this clinical trial assessing dosing, safety, and immunogenicity: 1. a fixed dose-ranging module, 2. an adaptive dose-finding/optimization module, and 3. a placebo-controlled expansion module.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
12/11/2022
Locations: Brigham and Women's Hospital Vaccine Unit, Boston, Massachusetts
Conditions: Cholera, Cholera Vaccine Toxicity
Register for Updates
Computer-based Training of Face Recollection to Improve Face Recognition in Developmental Prosopagnosia
NCT04799340
Recruiting
This study will examine the effectiveness of a cognitive training intervention targeting face recollection, repetition lag training, at improving face recognition in Developmental Prosopagnosia.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
11/23/2022
Locations: VA Boston Healthcare System, 150 S. Huntington Ave., Boston, Massachusetts
Conditions: Developmental Prosopagnosia
Register for Updates
Improving Spatial Perception and Speech Understanding in Multitalker Mixtures
NCT05260307
Recruiting
The purpose of this study is to investigate several approaches for improving spatial perception and speech intelligibility in multitalker listening situations for hearing-aid users. The hypotheses are that spatial perception and speech intelligibility will be improved by (1) increased high-frequency audibility, (2) speech envelope enhancement, and/or (3) appropriate sound image externalization.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
11/16/2022
Locations: Boston University, Boston, Massachusetts
Conditions: Hearing Loss
Register for Updates
Study on Allopregnanolone and Depression in Perimenopausal Women
NCT05329779
Recruiting
This study aims to identify how the progesterone metabolite allopregnanolone affects behavior and neurobiology that may underlie perimenopausal depression.
Gender:
FEMALE
Ages:
Between 40 years and 60 years
Trial Updated:
11/08/2022
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Depression
Register for Updates
MOON Shoulder Instability-Cohort of Patients Undergoing Operative Treatment.
NCT02075775
Recruiting
This project will be a multi-center, prospective longitudinal cohort for all patients undergoing primary shoulder instability surgery, excluding isolated SLAP repairs. We will be looking for risk factors for recurrent instability, revision surgery, and poor outcomes. Patients will be asked to complete the RAND-36, ASES, Shoulder Activity, EQ-5D and WOSI outcome measures, as well as demographic and socioeconomic information. Surgeons will complete a form after surgery with information on radiogra... Read More
Gender:
ALL
Ages:
Between 12 years and 99 years
Trial Updated:
11/07/2022
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Other Instability, Shoulder, Dislocations, Subluxations, Recurrent Dislocation of Shoulder Region
Register for Updates