There are currently 2707 clinical trials in Boston, Massachusetts looking for participants to engage in research studies. Trials are conducted at various facilities, including Massachusetts General Hospital, Dana Farber Cancer Institute, Brigham and Women's Hospital and Beth Israel Deaconess Medical Center. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Dexmedetomidine Infusion and Postoperative Lung Aeration After Thoracic Surgery
NCT06502002
Recruiting
This will be a randomized, placebo-controlled, double-blinded, pilot trial with two parallel groups (1:1 ratio) receiving either dexmedetomidine (initial bolus of 1 mcg/kg over 30 min after induction, followed by an infusion rate of 0.3 mcg/kg/hr that will be stopped 30-45 minutes before the end of the surgery or upon reaching maximum dose of 2mcg/kg, whichever comes first) or placebo (normal saline as a bolus followed by maintenance infusion at the same rate of the intervention group). Dexmede... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
08/21/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Surgery-Complications, Respiratory Complication, Lung Injury, Acute
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Neural Mechanisms of Family-Focused Treatment for Youth Depression
NCT06289010
Recruiting
The goal of this interventional study is to compare the baseline neural mechanisms and parenting in depressed and non-depressed children and to examine baseline neural mechanisms and parenting as predictors of Family-Focused Treatment for Childhood-Depression (FFT-CD) outcomes. The main questions it aims to answer are: * What are differences between depressed and non-depressed participants on baseline neural and parenting indicators? * Do baseline neural and parenting indicators predict respons... Read More
Gender:
ALL
Ages:
Between 7 years and 12 years
Trial Updated:
08/21/2024
Locations: Boston University, Boston, Massachusetts
Conditions: Childhood Depression
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S1803, Lenalidomide +/- Daratumumab/rHuPh20 as Post-ASCT Maintenance for MM w/MRD to Direct Therapy Duration
NCT04071457
Recruiting
Patients are enrolled to screening (Reg Step 1) prior to or after ASCT but prior to Reg Step 2. Patients are followed until they will begin Maintenance and then registered to Reg Step 2 (first randomization). Patients are randomized between Lenalidomide for 2 years and Lenalidomide + Daratumumab/rHuPH20. After 2 years of Maintenance, MRD is assessed to guide further therapy. MRD-positive patients will continue with the assigned treatment. MRD-negative patients will be further randomized (Reg Ste... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
08/21/2024
Locations: Boston Medical Center, Boston, Massachusetts
Conditions: Multiple Myeloma
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EPPIC-Net: Platform Protocol to Assess Treatments for Painful Diabetic Peripheral Neuropathy
NCT05476276
Recruiting
This is a Platform Protocol to perform Phase II clinical trials in The Early Phase Pain Investigation Clinical Network (EPPIC-Net), under The Helping to End Addiction Long-termSM Initiative, or NIH HEAL InitiativeSM, related to the treatment of Painful Diabetic Peripheral Neuropathy (PDPN) in a platform setting to test multiple assets under a single protocol.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/20/2024
Locations: MGH Department of Anesthesia, Critical Care, and Pain, Boston, Massachusetts
Conditions: Painful Diabetic Neuropathy
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Developing Fast Pediatric Imaging
NCT03761121
Recruiting
This research study is evaluating the investigational software for magnetic resonance imaging (MRI) systems and techniques to process magnetic resonance (MR) images
Gender:
ALL
Ages:
0 years and above
Trial Updated:
08/20/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts +2 locations
Conditions: Pediatric Low-grade Gliomas
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Advanced Fetal Imaging - Phase II
NCT02840019
Recruiting
The goal of Advanced Fetal Imaging - Phase II is to advance fetal MRI imaging by designing MRI coils specifically for pregnant women and testing recently developed MRI image acquisition techniques. The investigators aim to more reliably obtain higher quality fetal MRI images when compared to current clinical fetal MRI.
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
08/20/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Pregnancy
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MRI Assessment of Placental Health
NCT02297724
Recruiting
The ultimate goal of this project is to develop methods that allow informed decision-making on the delivery time of fetuses that are at increased risk of stillbirth due to IUGR. In placenta related IUGR pregnancies, there can be multiple concurrent placental pathologies. Although there is no specific correspondence between a single type of pathology and IUGR, the common result of these pathologies is placental insufficiency, which limits the maternal-fetal exchange. Oxygen and nutrition transpor... Read More
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
08/20/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Intrauterine Growth Restriction
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rHSC-DIPGVax Plus Checkpoint Blockade for the Treatment of Newly Diagnosed DIPG and DMG
NCT04943848
Recruiting
This is a phase I, open label, plus expansion clinical trial evaluating the safety and tolerability of rHSC-DIPGVax in combination with BALSTILIMAB and ZALIFRELIMAB. rHSC-DIPGVax is an off-the-shelf neo-antigen heat shock protein containing 16 peptides reflecting neo-epitopes found in the majority of DIPG and DMG tumors. Newly diagnosed patients with DIPG and DMG who have completed radiation six to ten weeks prior to enrollment are eligible.
Gender:
ALL
Ages:
Between 12 months and 18 years
Trial Updated:
08/20/2024
Locations: Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts
Conditions: Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, H3 K27M-Mutant
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Impact of Diet on the Gut-Muscle Axis in Older Adults
NCT05549622
Recruiting
Muscle health declines during aging. One factor that may impact muscle health is the community of bacteria that live in our intestines, but studies aimed at improving muscle health by targeting the gut in older adults are sparse. The primary goal of this study is to use a diet that is enriched in soluble fiber, which is exclusively utilized by gut bacteria to make substances that can impact muscle health, to improve muscle-related measures in older adults.
Gender:
ALL
Ages:
65 years and above
Trial Updated:
08/20/2024
Locations: Jean Mayer Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts
Conditions: Sarcopenia, Dietary Exposure, Microbial Colonization
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The Osteoarthritis Prevention Study
NCT05946044
Recruiting
The goal of this study is to establish the efficacy of an intervention of dietary weight loss, exercise, and weight-loss maintenance for knee Osteoarthritis (OA) prevention in adult females aged ≥ 50 years with obesity and no or infrequent knee pain. The primary aim is to compare the effects of a dietary weight loss, exercise, and weight-loss maintenance to an attention control group in preventing the development of structural Magnetic Resonance Imaging (MRI) knee OA. Secondary aims will determi... Read More
Gender:
FEMALE
Ages:
50 years and above
Trial Updated:
08/20/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Osteoarthritis, Knee
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Exposure-Based CBT for Avoidant/Restrictive Food Intake in Functional Dyspepsia
NCT05587127
Recruiting
Randomized controlled trial of an exposure-based behavioral treatment (CBT) in adults with functional dyspepsia who meet criteria for avoidant/restrictive food intake disorder (ARFID) with weight loss.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/19/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Avoidant/Restrictive Food Intake Disorder, Dyspepsia, Feeding and Eating Disorders, Cognitive Behavioral Therapy, Appetite Regulation, Functional Dyspepsia, Post-prandial Distress Syndrome, Behavioral Medicine
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A 90 Day, Phase 3,Open Labeled Exploratory Study of RELiZORB
NCT03530852
Recruiting
Children with inadequate intestinal absorption due to loss of large amounts of small bowel require intravenous nutrition (feeding through the vein) to sustain hydration and nutrition to avoid starvation and dehydration; however, intravenous (IV) nutrition can lead to complications including liver failure. Tube feeding directly to the small intestine avoids the complications of IV nutrition, but fats are not fully digestible due to inadequate bowel function. We propose to predigest the fat using... Read More
Gender:
ALL
Ages:
Between 2 years and 18 years
Trial Updated:
08/19/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Short Bowel Syndrome, Malabsorption
Register for Updates