There are currently 2781 clinical trials in Boston, Massachusetts looking for participants to engage in research studies. Trials are conducted at various facilities, including Massachusetts General Hospital, Dana Farber Cancer Institute, Beth Israel Deaconess Medical Center and Brigham and Women's Hospital. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Immunogenicity of the 9vHPV Vaccination 2-dose Regimen Among Children 4 to 8 Years Old, An Exploratory Immunogenicity Study
NCT05329961
Recruiting
This study is an open-label nonrandomized exploratory proof of concept and descriptive 4-year immunogenicity study to assess immunogenicity after administration of a 2-dose regimen of 9-valent human papillomavirus vaccine (9vHPV) vaccine separated by 12 months (months 0, 12).
Gender:
All
Ages:
Between 4 years and 8 years
Trial Updated:
10/02/2023
Locations: Boston Medical Center, Boston, Massachusetts
Conditions: Human Papilloma Virus
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A Phase I Intravesical PPM Therapy for NMIBC
NCT05519241
Recruiting
This clinical trial is to determine the safety and effectiveness of an investigational bladder cancer drug named "PLZ4-coated paclitaxel-loaded nanoscale micelle (PPM)." PPM is tiny particles that contain the chemotherapy drug paclitaxel. PLZ4 is a molecule that can possibly guide PPM to specifically target and deliver paclitaxel into and kill bladder cancer cells. In this trial, PPM will be instilled into the bladder cavity to treat bladder cancer that does not invade into the muscle layer of t... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
10/02/2023
Locations: VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston, Massachusetts
Conditions: Non-muscle-invasive Bladder Cancer
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Mobile CARE-App to Promote Coping for Caregivers of Patients Receiving Stem Cell Transplant
NCT05709912
Recruiting
The goal of this research study is to determine whether a self-administered, psychosocial mobile application (CARE app) is effective at improving the quality of life and experience of caregivers of patients receiving hematopoietic stem cell transplantation (HCT).
Gender:
All
Ages:
18 years and above
Trial Updated:
10/02/2023
Locations: Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Conditions: Bone Marrow Transplant Complications, Hematologic Malignancy
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Local Bisphosphonate Effect on Recurrence Rate in Extremity Giant Cell Tumor of Bone
NCT03295981
Recruiting
The purpose of the clinical study is to investigate whether the local delivery of bisphosphonate as a surgical adjuvant can decrease the chance of a giant cell tumor of bone coming back to the same location. The hypothesis is that the local administration of bisphosphonate will decrease the rate of the tumor returning compared to traditional aggressive surgical removal of the tumor.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/02/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts +2 locations
Conditions: Giant Cell Tumor of Bone
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A Phase 2a Study of LAM-001 for the Treatment of Pulmonary Hypertension
NCT05798923
Recruiting
This is a clinical trial to assess the efficacy and safety of LAM-001 as an add-on therapy for the treatment pulmonary hypertension.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/02/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Pulmonary Hypertension
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A Single-arm, Multicenter Study to Assess the Efficacy, Safety, and Tolerability of P1101 in Adults With ET
NCT05482971
Recruiting
A Single-arm, Multicenter Study to Assess the Efficacy, Safety, and Tolerability of Ropeginterferon alfa-2b-njft (P1101) in Adult Patients with Essential Thrombocythemia
Gender:
All
Ages:
18 years and above
Trial Updated:
10/01/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts +1 locations
Conditions: Essential Thrombocythemia
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Checkpoint Inhibition In Pediatric Hepatocellular Carcinoma
NCT04134559
Recruiting
This research study is studying an immunotherapy drug (pembrolizumab or KEYTRUDA) as a possible treatment for pediatric hepatocellular carcinoma or hepatocellular neoplasm not otherwise specified (HCN NOS).
Gender:
All
Ages:
Between 0 years and 30 years
Trial Updated:
09/30/2023
Locations: Children's Hospital Boston, Boston, Massachusetts +1 locations
Conditions: Hepatocellular Carcinoma, Childhood, Liver Cancer, Fibrolamellar Carcinoma, Liver Cancer, Pediatric
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Study to Evaluate R2R01 Plus Terlipressin Versus Terlipressin Alone in Patients With Hepatorenal Syndrome
NCT05875948
Recruiting
This study aims to evaluate the safety, tolerability and efficacy of R2R01 combined with terlipressin as compared to terlipressin alone in the treatment of patients with HRS-AKI
Gender:
All
Ages:
18 years and above
Trial Updated:
09/29/2023
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Hepatorenal Syndrome, Acute Kidney Injury
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Luspatercept and Lenalidomide (L2) in Lower-risk, Non-del(5q) MDS Patients
NCT04539236
Recruiting
The purpose of this study is to evaluate if the combination of drugs, Lenalidomide and Luspatercept, will help improve the treatment of anemia in patients with lower-risk Myelodysplastic Syndrome (MDS).
Gender:
All
Ages:
18 years and above
Trial Updated:
09/29/2023
Locations: Dana-Farber Cancer Institute, Boston, Massachusetts
Conditions: Myelodysplastic Syndromes
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TRUDI: TDXD+Durva in HER2+/Low IBC
NCT05795101
Recruiting
The purpose of this study is to test the safety and effectiveness of an investigational drug combination (trastuzumab deruxtecan and durvalumab) to learn whether the intervention works in treating Human Epidermal growth factor Receptor-2 (HER2)-expressing inflammatory breast cancer. The names of the study drugs involved in this study are: Trastuzumab deruxtecan Durvalumab
Gender:
Female
Ages:
18 years and above
Trial Updated:
09/28/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts +1 locations
Conditions: Invasive Breast Cancer, Inflammatory Breast Cancer Stage III, HER2-positive Breast Cancer, HER2 Low Breast Adenocarcinoma, Breast Cancer
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Surgical Treatments for Postamputation Pain
NCT05009394
Recruiting
This is a double-blind randomised controlled trial (RCT) which compares the effectiveness of three surgical techniques for alleviating residual limb pain (RLP), neuroma pain and phantom limb pain (PLP). The three surgical treatments are Targeted Muscles Reinnervation (TMR), Regenerative Peripheral Nerve Interface (RPNI), and an active control (neuroma excision and muscle burying). Patients will be follow-up for 4 years.
Gender:
All
Ages:
18 years and above
Trial Updated:
09/27/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Amputation Neuroma, Phantom Limb Pain, Pain, Neuropathic, Pain, Nerve, Residual Limb Pain
Register for Updates
Post-Approval Study of the TREO Abdominal Stent-Graft System
NCT04697784
Recruiting
The purpose of this study is to determine the long-term performance of the TREO Abdominal Stent-Graft as a treatment for patients with Infrarenal Abdominal Aortic Aneurysms or Aorto-iliac Aneurysms.
Gender:
All
Ages:
18 years and above
Trial Updated:
09/27/2023
Locations: Tufts Medical Center, Boston, Massachusetts
Conditions: Abdominal Aortic Aneurysm
Register for Updates