There are currently 2647 clinical trials in Boston, Massachusetts looking for participants to engage in research studies. Trials are conducted at various facilities, including Massachusetts General Hospital, Dana Farber Cancer Institute, Beth Israel Deaconess Medical Center and Brigham and Women's Hospital. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Skills to Enhance Positivity in Suicidal Youth
NCT04994873
Recruiting
This is a Hybrid Type I Effectiveness-Implementation design. Specifically, this study proposes to test the effectiveness of STEP in reducing suicidal events and ideation in 216 adolescents, admitted to inpatient psychiatric care due to suicide risk. Participants will be randomized to either STEP or ETAU. STEP involves 4 in-person sessions (3 individual, 1 family) focused on psychoeducation regarding positive and negative affect, mindfulness meditation, gratitude, and savoring. Mood monitoring pr... Read More
Gender:
ALL
Ages:
Between 12 years and 60 years
Trial Updated:
05/19/2024
Locations: Children's Hospital, Boston, Massachusetts
Conditions: Suicide, Attempted
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Genetic Studies of Strabismus, Nystagmus, and Associated Disorders
NCT04770519
Recruiting
Strabismus (misalignment of the eyes) often runs in families. In this study, the investigators are looking for genetic variants associated with strabismus and nystagmus. Three types of subects will be enrolled: (1) Families with at least 3 members with strabismus, (2) individuals with infantile esotropia and their parents and siblings, and (3) individuals with infantile nystagmus and their parents. Whole exome and/or whole genome sequencing will be used to identify genetic variants shared by fam... Read More
Gender:
ALL
Ages:
All
Trial Updated:
05/17/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Strabismus, Nystagmus, Congenital
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REFLECTION: A Clinical Practice Learning Program for Galleri®
NCT05205967
Recruiting
REFLECTION is a multi-center, prospective, non-interventional, cohort study that will enroll approximately 17,000 individuals who have opted to be screened with Galleri®, a blood-based, multi-cancer early detection (MCED) test in routine clinical settings. The purpose of the study is to understand the real-world experience of Galleri® in clinical settings.
Gender:
ALL
Ages:
22 years and above
Trial Updated:
05/17/2024
Locations: Boston VA Research Institute (VA Boston), Boston, Massachusetts
Conditions: Early Detection of Cancer, Cancer
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Paxalisib (GDC-0084) In Recurrent Or Refractory PCNSL
NCT04906096
Recruiting
This research study is studying a drug called Paxalisib (GDC-0084) as a possible treatment for primary central nervous system lymphoma (PCNSL)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/16/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts +1 locations
Conditions: Primary Central Nervous System Lymphoma, Non-Hodgkin Lymphoma of Extranodal Site
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Parkinson's Disease in Asian Americans
NCT05532982
Recruiting
The ultimate goal of this project is to use the findings to develop culturally appropriate programs and resources that can be disseminated to key stakeholders to improve access to PD care and increase inclusivity in PD research for Asian Americans. This study will serve as a first step towards developing broader community and patient education programs and active outreach campaigns to increase PD-specific literacy among Asian Americans. The results from this study will elucidate the role that la... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/16/2024
Locations: Tufts University School of Medicine, Boston, Massachusetts
Conditions: Parkinson's Disease
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Effect on Body Movement and Mental Skills in Patients Who Received Gadolinium-based Contrast Media for Magnetic Resonance Examination Multiple Times Within 5 Years
NCT04373564
Recruiting
This study is a postmarketing requirement jointly carried out by four NDA holders (Bayer AG, Bracco, GE Healthcare and Guerbet) and the CRO IQVIA. The study aims to create detailed images of the organs and tissue of the human body during x-ray, CT-scan or MRI investigations, doctors are using contrast media (a kind of dye) which can be given to patients by injection into a blood vessel or by mouth. In this study researchers want to find out whether so called gadolinium-based contrast agents (G... Read More
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
05/15/2024
Locations: Massachussets General Hospital, Boston, Massachusetts +2 locations
Conditions: Motor Function, Cognitive Function, Contrast Media
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Impact of Thrombocytopenia and Platelet Transfusions on Neonatal Bleeding and Inflammation
NCT03848923
Recruiting
This is a prospective observational study that was designed with the following two Specific Aims: 1. To determine whether the Immature Platelet Fraction percentage (IPF%) and the Immature Platelet Count (IPC) are better predictors of bleeding than the platelet count alone in neonates of different gestational and post-conceptional ages and with different etiologies of thrombocytopenia; and 2. To characterize the effects of neonatal thrombocytopenia and platelet transfusions (PLT Tx) on bleeding... Read More
Gender:
ALL
Ages:
Between 0 days and 6 months
Trial Updated:
05/14/2024
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts +1 locations
Conditions: Neonatal Thrombocytopenia
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Ketamine for OUD and Suicidal Ideation in the ED
NCT06111339
Recruiting
This is a pilot, double-blind, placebo-controlled randomized clinical trial of individuals with opioid use disorder (OUD) with suicidal ideation in the emergency department (ED) to receive either a single infusion of ketamine 0.8mg/kg (n=25) or saline placebo (n=25). The primary aim is to evaluate the safety of the ketamine treatment. The secondary aim is to determine the preliminary efficacy of opioid- and suicide-related outcomes.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/14/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Opioid Use Disorder, Suicidal Ideation
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Targeting Specific Brain Networks to Treat Specific Symptoms in Depression
NCT05523817
Recruiting
Repetitive transcranial magnetic stimulation (rTMS) is a way of non-invasively stimulating specific brain networks and is an established treatment for Major Depressive Disorder (MDD). This proposal will reveal network mechanisms of the therapeutic effects of rTMS by investigating how stimulating each network specifically changes network connectivity and behavior. This will be done in a highly individualized manner in depressed and healthy patients, leading to more effective and more individualiz... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
05/14/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Major Depressive Disorder
Register for Updates
Implementation of Whole Genome Sequencing as Screening in a Diverse Cohort of Healthy Infants
NCT05161169
Recruiting
This research study is exploring the use of genomic sequencing in the newborn period to screen healthy babies for current and future health risks. The study will enroll a diverse cohort of 500 healthy infants and their parents from Boston, MA; New York City, NY; and Birmingham, AL. A small blood sample will be collected from each infant, and whole genome sequencing will be performed in 1/2 of the cohort following a randomized controlled trial design. 3 months later, the randomization status and... Read More
Gender:
ALL
Ages:
Between 0 months and 12 months
Trial Updated:
05/14/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Genetic Predisposition to Disease, Hereditary Diseases
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IMPact on Revascularization Outcomes of IVUS Guided Treatment of Complex Lesions and Economic Impact
NCT04221815
Recruiting
Intravascular ultrasound (IVUS)-guided percutaneous coronary intervention (PCI) has been shown in clinical trials, registries, and meta-analyses to reduce recurrent events after PCI. This is accomplished by improving the angiographic result with lesion and vessel assessment to guide stent selection and implantation and intravascular imaging following stent implantation to ensure an adequate treatment endpoint has been achieved. Despite extensive literature supporting the use of IVUS in PCI, util... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/14/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts +1 locations
Conditions: Atherosclerosis
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Oxytocin for Weight Loss in Adolescents
NCT04551482
Recruiting
This is a randomized, double blind, placebo-controlled study of the effects of intranasal oxytocin in youths with obesity, ages 12-18 years old. Subjects will be randomized to receive intranasal oxytocin or placebo (3 sprays per nostril, 4 times per day) for 12 weeks. Study visits include screening to determine eligibility, 2-part main study visits at baseline, week 8, and week 12, and safety check-in visits at weeks 1, and 4; phone calls at weeks 2, 6, and 10, with a safety follow-up visit 6 we... Read More
Gender:
ALL
Ages:
Between 12 years and 18 years
Trial Updated:
05/14/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Obesity, Adolescent, Oxytocin
Register for Updates