There are currently 2699 clinical trials in Boston, Massachusetts looking for participants to engage in research studies. Trials are conducted at various facilities, including Massachusetts General Hospital, Dana Farber Cancer Institute, Brigham and Women's Hospital and Beth Israel Deaconess Medical Center. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
EPPIC-Net: Platform Protocol to Assess Treatments for Painful Diabetic Peripheral Neuropathy
NCT05476276
Recruiting
This is a Platform Protocol to perform Phase II clinical trials in The Early Phase Pain Investigation Clinical Network (EPPIC-Net), under The Helping to End Addiction Long-termSM Initiative, or NIH HEAL InitiativeSM, related to the treatment of Painful Diabetic Peripheral Neuropathy (PDPN) in a platform setting to test multiple assets under a single protocol.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/20/2024
Locations: MGH Department of Anesthesia, Critical Care, and Pain, Boston, Massachusetts
Conditions: Painful Diabetic Neuropathy
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A 90 Day, Phase 3,Open Labeled Exploratory Study of RELiZORB
NCT03530852
Recruiting
Children with inadequate intestinal absorption due to loss of large amounts of small bowel require intravenous nutrition (feeding through the vein) to sustain hydration and nutrition to avoid starvation and dehydration; however, intravenous (IV) nutrition can lead to complications including liver failure. Tube feeding directly to the small intestine avoids the complications of IV nutrition, but fats are not fully digestible due to inadequate bowel function. We propose to predigest the fat using... Read More
Gender:
ALL
Ages:
Between 2 years and 18 years
Trial Updated:
08/19/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Short Bowel Syndrome, Malabsorption
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Effects of Whole vs. Nonfat Milk Consumption on Body Composition in Children
NCT05464186
Recruiting
This study will evaluate the effects of whole vs. nonfat milk consumption on body composition, cardiometabolic disease risk factors, and dietary quality.
Gender:
ALL
Ages:
Between 9 years and 12 years
Trial Updated:
08/19/2024
Locations: New Balance Foundation Obesity Prevention Center, Boston, Massachusetts
Conditions: Obesity, Diabetes, Cardiovascular Diseases
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Exposure-Based CBT for Avoidant/Restrictive Food Intake in Functional Dyspepsia
NCT05587127
Recruiting
Randomized controlled trial of an exposure-based behavioral treatment (CBT) in adults with functional dyspepsia who meet criteria for avoidant/restrictive food intake disorder (ARFID) with weight loss.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/19/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Avoidant/Restrictive Food Intake Disorder, Dyspepsia, Feeding and Eating Disorders, Cognitive Behavioral Therapy, Appetite Regulation, Functional Dyspepsia, Post-prandial Distress Syndrome, Behavioral Medicine
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Self-Adjusted Nitrous Oxide: A Feasibility Study in the Setting of Vasectomy
NCT05895383
Recruiting
This study is being done to see if nitrous oxide during vasectomy decreases pain and anxiety, and also assess whether patients have better satisfaction when they control their own level of nitrous oxide during the procedure. If we find that patients experience less pain or anxiety with nitrous oxide, it could be suggested that self-adjusted nitrous oxide (SANO) may be a useful tool for improving experience of care during vasectomy.
Gender:
MALE
Ages:
Between 21 years and 85 years
Trial Updated:
08/17/2024
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Procedural Pain, Pain Catastrophizing, Procedural Anxiety
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A Phase II Evaluation of Afatinib in Patients With Persistent or Recurrent HER2-positive Uterine Serous Carcinoma
NCT02491099
Recruiting
Primary Objective: To assess the activity of Afatinib in patients with persistent or recurrent uterine serous carcinoma overexpressing HER2/neu with the frequency of patients who survive progression-free for at least 6 months after initiating therapy. Secondary Objectives: To assess objective response rate and durable disease control rate. To assess overall survival. To assess the safety profile of Afatinib in uterine serous carcinoma patients.
Gender:
FEMALE
Ages:
Between 18 years and 100 years
Trial Updated:
08/16/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: HER2/Neu+ Uterine Serous Carcinoma
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Androgen Receptor Signaling and Prostate-Specific Membrane Antigen Expression
NCT05683964
Recruiting
The goal of this research study is to determine whether hormonal therapies used early in the course of prostate cancer could increase the amount of Prostate-Specific Membrane Antigen (PSMA) as detected by PET/CT scans for participants with recurrent prostate cancer. This study will measure PSMA levels using standard PET/CT scans and participants will receive standard-of-care androgen receptor antagonist monotherapy. The names of the treatment interventions involved in this study are: * Androge... Read More
Gender:
MALE
Ages:
40 years and above
Trial Updated:
08/15/2024
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Prostate Adenocarcinoma, Prostate Cancer, Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)
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Child and Adolescent Registry for Participants With Narcolepsy
NCT04899947
Recruiting
CATNAP is a patient registry designed to improve the understanding of the natural history of narcolepsy in pediatric patients. Descriptive statistics on disease characteristics will be performed. The study has 16 active clinical sites and a virtual site that widens participation to anywhere in the United States. For more information about the study or to access the Online Patient Enrollment System, visit the CATNAP website: https://catnap.healthie.net/welcome or email catnap@pulseinfoframe.com.... Read More
Gender:
ALL
Ages:
17 years and below
Trial Updated:
08/13/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Narcolepsy
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Tau PET/CT Imaging in the Mismatch Prospective Cohort Study (MPC-TAU)
NCT05658913
Recruiting
To collect Tau PET/CT imaging in older adults diagnosed with Mild Cognitive Impairment (MCI) or Alzheimer's Disease (AD) in the Mismatch Prospective Cohort Study (MPC-Tau) study to determine relationship to clinical, cognitive, and other biomarker data. Findings from this study will likely provide insight into the phenotypic variability of Alzheimer's Disease and other related pathologies.
Gender:
ALL
Ages:
Between 18 years and 120 years
Trial Updated:
08/13/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Alzheimer's Disease
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The PRECISION II Study: Evaluating the Accuracy of the LabPatch Glucose Sensing System
NCT05754281
Recruiting
The purpose of this study is to evaluate the accuracy of the Cambridge Medical Technologies, LLC second generation (2nd Gen) LabPatch glucose sensing system compared to a laboratory glucose analyzer (YSI 2300 STAT Plus) and 2 commercial glucometers, OneTouch Verio and Freestyle Lite. The primary endpoint of this study is the mean absolute relative difference (MARD) for 2nd Gen LabPatch system compared to each of the above mentioned glucose references over a 6 hour outpatient visit.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
08/13/2024
Locations: Joslin Diabetes Center, Boston, Massachusetts
Conditions: Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus
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US National OCS Liver Perfusion (OLP) Registry
NCT05940857
Recruiting
This Registry is a sponsor-initiated, multi-center, observational, post-approval registry with an independent academic oversight. TransMedics has contracted with United Network for Organ Sharing (UNOS) the Federal manager of the U.S. national transplant outcomes registry to obtain data that is routinely collected by the Organ Procurement and Transplantation Network (OPTN) on all transplanted organs in the U.S. for both the OCS liver transplanted patients as well as patients transplanted using o... Read More
Gender:
ALL
Ages:
All
Trial Updated:
08/13/2024
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Liver Transplant
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Mobile App-based Approach for Reducing Pain and Hazardous Drinking: a Pilot Study
NCT06281821
Recruiting
Chronic pain and heavy drinking are common co-occurring conditions among patients presenting to primary care settings. Given their impact on functioning and medical outcomes, there would be considerable benefit to developing an accessible, easily utilized, integrative approach to reduce alcohol use and pain that can be readily incorporated into the health care settings. The objective of this study is to test a modified version of a smartphone-based intervention for reducing pain and alcohol use... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/13/2024
Locations: Boston University, Boston, Massachusetts
Conditions: Alcohol Drinking, Chronic Pain
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