There are currently 2781 clinical trials in Boston, Massachusetts looking for participants to engage in research studies. Trials are conducted at various facilities, including Massachusetts General Hospital, Dana Farber Cancer Institute, Beth Israel Deaconess Medical Center and Brigham and Women's Hospital. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Life-Steps Counseling to Enhance Adherence and Engagement in PrEP Care
NCT04316715
Recruiting
The purpose of this study is to test how different types of interventions may affect how someone takes their pre-exposure prophylaxis (PrEP) medication.
Gender:
Male
Ages:
18 years and above
Trial Updated:
08/14/2023
Locations: Fenway Health, Boston, Massachusetts
Conditions: Adherence, Medication
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Effect of Vitamin D Status and Repletion on Postoperative Total Joint Arthroplasty Complications
NCT04229368
Recruiting
Vitamin D status has been shown to have an effect on post-operative outcomes in total joint arthroplasty. The goal of this study is to determine if pre-operative supplementation and correction of Vitamin D deficiency can reduce postoperative complications.
Gender:
All
Ages:
18 years and above
Trial Updated:
08/14/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Hip Arthropathy, Knee Arthropathy, Vitamin D Deficiency
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RESIST-ADT (Androgen Deprivation Therapy)
NCT04485767
Recruiting
The overall goal of this study is to determine if implementing structured exercises prevent decline in muscle mass, muscle strength and physical function in men with prostate cancer undergoing androgen deprivation therapy (ADT). Our main hypothesis is that structured resistance exercise training in men undergoing ADT will preserve physical function assessed by loaded stair climbing power compared with the control group. The trial will also examine the efficacy of the exercise regimen on muscle s... Read More
Gender:
Male
Ages:
60 years and above
Trial Updated:
08/14/2023
Locations: Dana-Farber Cancer Institute, Boston, Massachusetts +1 locations
Conditions: Prostate Cancer, Physical Function
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The Relationship Between Brain MRI Phenotypes, Genes and Cognitive Outcome in CHD Adults
NCT05258981
Recruiting
The main purpose of this proposal is to perform novel MRI analyses to determine the brain organizational changes associated with altered executive function and the modulating role of variants in neuroresilience and hypoxia response genes in adults with d-transposition of the great arteries (d-TGA).
Gender:
All
Ages:
Between 24 years and 35 years
Trial Updated:
08/14/2023
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Congenital Heart Disease
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Veterans Coordinated Community Care (3C) Study
NCT05272176
Recruiting
Veterans Coordinated Community Care (3C) Study will recruit 850 Veterans at risk for suicide post inpatient hospitalization. Each participant will be randomly assigned to treatment as usual (TAU) or TAU plus the Coping Long Term with Active Suicide Program (CLASP), with follow-up for 6 months after discharge. Outcomes include suicide-related behaviors (including deaths due to suicide, opioid overdose, or other substance-related accidents; and nonfatal suicide attempts) and suicidal ideation and... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
08/14/2023
Locations: VA Boston Healthcare System, Boston, Massachusetts
Conditions: Suicide
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Testing Sacituzumab Govitecan Therapy in Patients With HER2-Negative Breast Cancer and Brain Metastases
NCT04647916
Recruiting
This phase II trial studies the effect of sacituzumab govitecan in treating patients with HER2-negative breast cancer that has spread to the brain (brain metastases). Sacituzumab govitecan is a monoclonal antibody, called sacituzumab, linked to a chemotherapy drug, called govitecan. Sacituzumab is a form of targeted therapy because it attaches to specific molecules on the surface of cancer cells, known as Trop-2 receptors, and delivers govitecan to kill them. Giving sacituzumab govitecan may shr... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
08/11/2023
Locations: Dana-Farber Cancer Institute, Boston, Massachusetts
Conditions: Anatomic Stage IV Breast Cancer AJCC v8, Invasive Breast Carcinoma, Metastatic HER2 Negative Breast Carcinoma, Metastatic Malignant Neoplasm in the Brain, Prognostic Stage IV Breast Cancer AJCC v8
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S1803, Lenalidomide +/- Daratumumab/rHuPh20 as Post-ASCT Maintenance for MM w/MRD to Direct Therapy Duration
NCT04071457
Recruiting
Patients are enrolled to screening (Reg Step 1) prior to or after ASCT but prior to Reg Step 2. Patients are followed until they will begin Maintenance and then registered to Reg Step 2 (first randomization). Patients are randomized between Lenalidomide for 2 years and Lenalidomide + Daratumumab/rHuPH20. After 2 years of Maintenance, MRD is assessed to guide further therapy. MRD-positive patients will continue with the assigned treatment. MRD-negative patients will be further randomized (Reg Ste... Read More
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
08/11/2023
Locations: Boston Medical Center, Boston, Massachusetts
Conditions: Multiple Myeloma
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Bone Mineral Density Status in Pediatric and Adolescent Survivors of Childhood Cancer With History of Bone Fracture
NCT02355340
Recruiting
This research study is evaluating bone mineral density in childhood cancer survivors who have a history of bone fracture.
Gender:
All
Ages:
Between 8 years and 20 years
Trial Updated:
08/11/2023
Locations: Boston Children's Hospital, Boston, Massachusetts +1 locations
Conditions: Bone Mineral Density, Childhood Cancer Survivors
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A Study to Evaluate the PK and PD of IM or SQ Injections of Levonorgestrel Butanoate (LB) for Female Contraception
NCT04143659
Recruiting
This is a Phase I multicenter, open-label, dose-ranging, three-dose PK and PD study of injectable LB administered as an IM or SQ injection at 40 mg, and subsequently at 50mg SQ and then 60 mg SQ depending on the preliminary pharmacokinetic and pharmacodynamic results obtained with 40 mg dosing.
Gender:
Female
Ages:
Between 18 years and 40 years
Trial Updated:
08/11/2023
Locations: Boston Medical Center Corporation, Boston, Massachusetts
Conditions: Healthy Women, Female Contraception
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Prehabilitation Exercise Training in Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation
NCT05706766
Recruiting
The goal of this research study is to investigate whether a virtual, home-based, prehabilitation aerobic and resistance exercise (PARE) training program implemented 8 weeks prior to receiving autologous stem cell transplant (ASCT) for multiple myeloma participants will improve muscular strength, physical capacity, patient reported outcomes, and cardiometabolic health outcomes. The names of the study interventions involved in this study are: Prehabilitative aerobic and resistance exercise (PARE... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
08/10/2023
Locations: Dana Farber Cancer Institute, Boston, Massachusetts +1 locations
Conditions: Multiple Myeloma, Stem Cell Transplant Complications
Register for Updates
NIRS Monitoring in Premature Infants
NCT02601339
Recruiting
This study uses frequency domain near-infrared spectroscopy coupled with diffuse correlation spectroscopy (FDNIRS-DCS) technology for monitoring cerebral blood flow (CBF) and cerebral oxygen metabolism (CMRO2) at the bedside for newborns with germinal matrix-intraventricular hemorrhage (GM-IVH) and/or post-hemorrhagic hydrocephalus (PHH) in comparison to newborns with hydrocephalus of a different etiology (VC) and healthy controls (HC). We hypothesize that baseline cerebral metabolic dysfunction... Read More
Gender:
All
Ages:
Between 0 months and 12 months
Trial Updated:
08/09/2023
Locations: Boston Children's Hospital, Boston, Massachusetts +2 locations
Conditions: Hemorrhage, Premature Infants, Newborn, Hydrocephalus
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Preterm Lung Patient Registry
NCT00951366
Recruiting
The goal of the Preterm Lung Patient Registry is to collect data on individuals with neonatal lung disease to better understand the illness and ultimately improve their care and survival. The Patient Registry was established in 2008 as a means to monitor important trends in the BPD population and to improve understanding, treatment, and survival.
Gender:
All
Ages:
All
Trial Updated:
08/09/2023
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Bronchopulmonary Disease
Register for Updates