There are currently 2781 clinical trials in Boston, Massachusetts looking for participants to engage in research studies. Trials are conducted at various facilities, including Massachusetts General Hospital, Dana Farber Cancer Institute, Beth Israel Deaconess Medical Center and Brigham and Women's Hospital. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Predicting Progression of Developing Myeloma in a High-Risk Screened Population (PROMISE)
Recruiting
The PROMISE Study aims to establish a prospective cohort of individuals with precursor conditions to multiple myeloma, such as monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM). We will study these patients as a means to identify risk factors for progression to symptomatic multiple myeloma.
Gender:
All
Ages:
30 years and above
Trial Updated:
07/30/2023
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: Multiple Myeloma
Phase 1a and Phase 2 Study for Safety, Preliminary Efficacy, PK and PD of ST-067
Recruiting
This is a multiphase, multicenter study, which includes a Phase 1a open-label, dose escalation monotherapy study of ST-067 given as an SC injection with or without obinutuzumab [Gazyva®] pre-treatment, by IV infusion, and in combination with pembrolizumab. A Phase 2 monotherapy arm is also planned; the exact design of the Phase 2 study elements with respect to formulation and pre-treatment will be determined after completion of the Phase 1 study portion of the trial.
Gender:
All
Ages:
18 years and above
Trial Updated:
07/30/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Cancer, Solid Tumor, Melanoma, Renal Cell Carcinoma, Triple-negative Breast Cancer, Non Small Cell Lung Cancer, Squamous Cell Carcinoma of the Head and Neck, Carcinoma, MSI-High
A Pilot Study of Fenofibrate to Prevent Kidney Function Loss in Type 1 Diabetes
Recruiting
Diabetic kidney disease remains the leading cause of end-stage kidney disease (ESKD), rising in frequency in parallel with the epidemic of diabetes worldwide. The estimated lifetime risk of kidney disease in persons with type 1 diabetes (T1D) has been reported to be as high as 50-70%, although risk may be lower in excellent care environments. Two previous studies have suggested that a generic drug used to lower fats in blood (fenofibrate) may protect the kidney from damage due to diabetes. These... Read More
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
07/29/2023
Locations: Joslin Diabetes Center, Boston, Massachusetts
Conditions: Diabetic Nephropathies
Atrial Late Gadolinium Enhancement in Patients With Repaired Congenital Heart Disease
Recruiting
In this research study the investigators want to learn more about how well the investigators can visualize scar tissue in the heart by MRI. In patients with congenital heart disease who need a procedure in the electrophysiology laboratory, how the MRI findings match the findings in the electrophysiology laboratory is not known. This study works to answer these questions. Participants will undergo a cardiac MRI as part of the routine clinical care that was ordered by their doctors and additional... Read More
Gender:
All
Ages:
13 years and above
Trial Updated:
07/28/2023
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Congenital Heart Disease, Fibrosis Myocardial, Fibrosis; Heart
Multi-Center Development of a Novel Diagnostic Test for Alzheimer's Disease
Recruiting
In this multi-center study, the investigators plan to develop a simple blood-based test for early detection of Alzheimer's disease (AD). The test is based on a single injection of Pramlintide, an amylin analogue and FDA-approved drug currently used for treatment of diabetes. The investigative team has provided evidence in humans with full-blown AD and AD-relevant mouse models that a single injection of Pramlintide transiently renders the blood brain barrier (BBB) more permeable to Amyloidbeta (A... Read More
Gender:
All
Ages:
Between 60 years and 90 years
Trial Updated:
07/28/2023
Locations: BU Alzheimer Disease Center, Boston, Massachusetts
Conditions: Alzheimer Disease, Mild Cognitive Impairment
Feasibility of [11C]Acetate-PET in LAM and TSC
Recruiting
This study aims to assess [11C]acetate positron emission tomography (PET)/computed tomography (CT) as a biomarker for renal angiomyolipomas and pulmonary lymphangioleiomyomatosis (LAM) and an early biomarker of response to rapamycin in LAM patients. [11C]Acetate is a radioactive form of acetate, a nutrient commonly processed in our body's cells to generate fat and energy. Preclinical studies support the hypothesis that TSC tumors enhance lipid synthesis compared to normal tissues, suggesting th... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
07/28/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Lymphangioleiomyomatosis, Tuberous Sclerosis Complex
A 90 Day, Phase 3,Open Labeled Exploratory Study of RELiZORB
Recruiting
Children with inadequate intestinal absorption due to loss of large amounts of small bowel require intravenous nutrition (feeding through the vein) to sustain hydration and nutrition to avoid starvation and dehydration; however, intravenous (IV) nutrition can lead to complications including liver failure. Tube feeding directly to the small intestine avoids the complications of IV nutrition, but fats are not fully digestible due to inadequate bowel function. We propose to predigest the fat using... Read More
Gender:
All
Ages:
Between 2 years and 18 years
Trial Updated:
07/28/2023
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Short Bowel Syndrome, Malabsorption
Home-based Neuromodulation to Target Depression And Memory Symptoms in Older Adults
Recruiting
This project aims to explore the feasibility and effects of a symptom-specific, brain-circuit-based, home-based neuromodulation therapy for addressing mood and memory symptoms in older adults with major depressive disorder (MDD) in the context of dementia.
Gender:
All
Ages:
55 years and above
Trial Updated:
07/27/2023
Locations: Hinda and Arthur Marcus Institute for Aging Research, Boston, Massachusetts
Conditions: Major Depressive Disorder, Alzheimer Disease, Dementia, Nervous System Diseases, Memory Disorders, Depressive Disorder
COVID-19-Related Opioid Treatment Policy Evaluation
Recruiting
Our nation is facing the COVID-19 pandemic during an ongoing opioid epidemic. Effective treatment for patients with opioid use problems involves a treatment method called Medication-Assisted Treatment, or MAT. In MAT, patients receive a medication that reduces cravings and withdrawal symptoms and can prevent overdose. Patients also receive counseling. Because the medications that are used in MAT are controlled substances, this treatment is subject to a number of federal regulations. The need for... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
07/27/2023
Locations: VA Boston Healthcare System, Boston, Massachusetts
Conditions: Opioid-use Disorder, Alcohol Use Disorder
MR Antagonist and LSD1
Recruiting
Lysine specific demethylase-1 (LSD1) is an epigenetic regulator of gene transcription involved in the pathophysiology of elevated blood pressure and likely renal damage in Blacks. This project investigates whether a genetically driven anti-hypertensive approach proves superior in controlling blood pressure and mitigating renal injury in Blacks who carry the risk allele for LSD1 (rs587168). The findings of these investigations may lead to a new approach in treating a subset (~30%) of the essentia... Read More
Gender:
All
Ages:
17 years and above
Trial Updated:
07/27/2023
Locations: Brigham and Women's, Boston, Massachusetts
Conditions: Hypertension, Mineralocorticoid Excess
Vascularized Composite Allotransplantation for Treatment of Abdominal Wall Defects
Recruiting
Abdominal wall transplantation surgery is the transfer of abdominal wall tissues from a deceased human donor to a patient with a large abdominal wall defect. Abdominal wall transplantation is an innovative reconstructive procedure that has the potential to significantly improve the lives of patients with large abdominal wall defects. The purpose of this study is to develop the best practices for abdominal wall transplantation that will improve the outcomes of future abdominal wall transplant rec... Read More
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
07/26/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Abdominal Wall Defect
InAdvance: Surveillance, Prevention, and Interception in a Population at Risk for Cancer
Recruiting
This research study is creating a way to collect and store specimens and information from participants who may be at an increased risk of developing cancer, or has been diagnosed with an early phase of a cancer or a family member who has a family member with a precursor condition for cancer. The objective of this study is to identify exposures as well as clinical, molecular, and pathological changes that can be used to predict early development of cancer, malignant transformation, and risks of... Read More
Gender:
All
Ages:
All
Trial Updated:
07/26/2023
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: Cancer Risk, Cancer Predisposition Syndrome, Hereditary Cancer Prediction, Childhood Cancer Survivors, Adult Cancer Survivors, IARC Carcinogens, Smoking History, Lung Cancer, Ductal/Lobular Carcinoma, Barrett Esophagus, Pancreatic Precursor Lesions, Colonic Dysplasia/Adenomata, Non-Alcoholic Fatty Liver Disease, Non Alcoholic Steatohepatitis, Cirrhosis, High Grade Prostatic Epithelial Neoplasia, High-grade Bladder Urothelial Dysplasia/Carcinoma in Situ, Adenomatous Hyperplasia, High-risk Oral Precancerous Diseases, Melanocytic Lesion, Adult, Hematologic Malignancy, Lung; Node, Serous Tubal Intraepithelial Carcinoma, Endometrial Intraepithelial Neoplasia, Cervical and Endocervical Carcinoma in Situ, Vulvar Intraepithelial Neoplasia, Nephrogenic Rests, Benign Bone Lesions With Risk of Malignant Degeneration, Giant Cell Tumor, Osteochondroma, Spitz Nevus