There are currently 2700 clinical trials in Boston, Massachusetts looking for participants to engage in research studies. Trials are conducted at various facilities, including Massachusetts General Hospital, Dana Farber Cancer Institute, Brigham and Women's Hospital and Beth Israel Deaconess Medical Center. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
A Study of TSR-022 in Participants With Advanced Solid Tumors (AMBER)
NCT02817633
Recruiting
This is a first-in-human study evaluating the anti-T cell immunoglobulin and mucin containing protein-3 (TIM-3) antibody TSR-022. The study will be conducted in 2 parts with Part 1 consisting of dose escalation and Part 2 dose expansion. Part 1 will determine the recommended Phase 2 dose (RP2D) of TSR-022 and Part 2 will evaluate the antitumor activity of TSR-022 in combination with TSR-042 or docetaxel and as monotherapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/18/2024
Locations: GSK Investigational Site, Boston, Massachusetts +1 locations
Conditions: Neoplasms
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Anti-Inflammatory Treatment of Uremic Cardiomyopathy With Colchicine
NCT04500665
Recruiting
This study is designed to determine the efficacy and safety of colchicine in patients with chronic kidney disease.
Gender:
ALL
Ages:
Between 21 years and 80 years
Trial Updated:
06/18/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Chronic Kidney Diseases
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Oral Tafenoquine Plus Standard of Care Versus Placebo Plus Standard of Care for Babesiosis
NCT06207370
Recruiting
This study is a double-blind, randomized, multisite, placebo-controlled trial comparing the safety and efficacy of TQ versus placebo in patients hospitalized for babesiosis with low risk for relapsing disease who will also be administered a standard-of-care antimicrobial regimen (A/A) that is recommended in the 2020 IDSA guideline on the diagnosis and management of babesiosis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/18/2024
Locations: Tufts Medical Center, Boston, Massachusetts
Conditions: Babesiosis
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Molecular and Genetic Studies of Congenital Myopathies
NCT00272883
Recruiting
In the Congenital Myopathy Research Program at Boston Children's Hospital and Harvard Medical School, the researchers are studying the congenital myopathies (neuromuscular diseases present from birth), including central core disease, centronuclear/myotubular myopathy, congenital fiber type disproportion, multiminicore disease, nemaline myopathy, rigid spine muscular dystrophy, SELENON (SEPN1), RYR1 myopathy, ADSS1 (ADSSL) Myopathy and undefined congenital myopathies. The primary goal of the rese... Read More
Gender:
ALL
Ages:
All
Trial Updated:
06/17/2024
Locations: Genetics Division, Boston Children's Hospital, Boston, Massachusetts
Conditions: Central Core Disease, Centronuclear Myopathy, Congenital Fiber Type Disproportion, Multiminicore Disease, Myotubular Myopathy, Nemaline Myopathy, Rigid Spine Muscular Dystrophy, Undefined Congenital Myopathy
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Predicting SSRI Efficacy in Veterans With PTSD
NCT04183205
Recruiting
This is a research study to examine the effectiveness of a brief screening method that may predict which people with posttraumatic stress disorder (PTSD) or depression are most likely to show a positive response to selective serotonin reuptake inhibitor (SSRI) medications. Participants will be recruited over approximately 5.25 years, until at least 94 participants complete the 17 week study.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
06/17/2024
Locations: VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston, Massachusetts
Conditions: Posttraumatic Stress Disorder, Major Depressive Disorder
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Vertical Soft Tissue Augmentation With CTG vs ADM
NCT05729607
Recruiting
The study aims at comparing two different approaches for vertical soft tissue augmentation at implant sites exhibiting soft tissue dehiscences: autogenous connective tissue graft vs acellular dermal matrix + enamel matrix derivative
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
06/17/2024
Locations: Harvard School of Dental Medicine, Boston, Massachusetts
Conditions: Implant Complication
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EXHIT ENTRE Implementation Trial of High Intensity Versus Low Intensity Strategy
NCT04921787
Recruiting
This study is a multi-site, cluster randomized, two group implementation trial comparing a low- versus high-intensity implementation strategy for supporting hospital-based opioid use disorder treatment (HBOT) in community hospital settings where medication for opioid use disorder (MOUD) treatment has not been implemented.
Gender:
ALL
Ages:
All
Trial Updated:
06/14/2024
Locations: Boston University, Boston, Massachusetts
Conditions: Substance Use Disorders, Opioid Use Disorder, Severe, Opioid Use Disorder, Moderate
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Phase I Study of Cell Therapies for the Treatment of Patients With Relapsed or Refractory AML or High-risk MDS
NCT05457010
Recruiting
The purpose of this study is to evaluate the safety and preliminary activity of ARC-T cells and SPRX002 in participants with relapsed or refractory acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/10/2024
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: Acute Myeloid Leukemia, Myelodysplastic Syndromes
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Category Learning Retention in Adults With and Without Developmental Language Disorder
NCT05901493
Recruiting
Approximately 7% of the population experiences developmental language disorder (DLD), a language disorder with unclear causes. DLD affects communication beyond adolescence and poses challenges for education and career advancement due to difficulties in learning and memory. Recent research suggests that adults with DLD struggle with overnight memory consolidation, indicating a need for effective learning and memory support. This project aims to determine the optimal training schedule for perceptu... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
06/10/2024
Locations: Northeastern University, Boston, Massachusetts
Conditions: Developmental Language Disorder, Adults Without Language Disorder
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Neuroactive Steroid to Treat Depressed Mood: A Trial for People With HIV
NCT05570812
Recruiting
This study will determine the effects of pregnenolone on brain function, inflammation and depressive symptoms in people with HIV who have depression. Participants in this study will receive a pill of either pregnenolone or placebo, and can stay on their current antidepression medications. Brain imaging and behavioral assessments will be performed during the study.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
06/07/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Major Depressive Disorder, Anxiety Depression, Hiv
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Toward Understanding Drivers of Patient Engagement With Digital Mental Health Interventions - Part II
NCT05555875
Recruiting
This study is a clinical trial that evaluates what drives patient engagement and tests the impact of two strategies-automated motivational push messaging and coach support-to improve engagement with an evidence-based mobile app intervention for depression and/or anxiety.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
06/05/2024
Locations: Jessica Morrow Lipschitz, Boston, Massachusetts
Conditions: Depression, Anxiety Disorders
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Rescue Pharmacotherapy for OSA
NCT05293600
Recruiting
Persistent obstructive sleep apnea (OSA) is common in people treated with mandibular advancement device (MAD) or hypoglossal nerve stimulation (HGNS). For most patients, these treatments are the last line of defense. If MAD or HGNS do not work, then patients are left to suffer the consequences of undertreated OSA. In this study, the investigators want to test the addition of a drug treatment to their regimen. Endotypes will be targeted pharmacologically with one of the following drugs: acetazola... Read More
Gender:
ALL
Ages:
Between 21 years and 70 years
Trial Updated:
06/03/2024
Locations: Sleep Disorders Research Program Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Obstructive Sleep Apnea
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