There are currently 2781 clinical trials in Boston, Massachusetts looking for participants to engage in research studies. Trials are conducted at various facilities, including Massachusetts General Hospital, Dana Farber Cancer Institute, Beth Israel Deaconess Medical Center and Brigham and Women's Hospital. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Concurrent Laparoscopic Hysterectomy and Weight Loss Surgery in Obese Patients With Endometrial Carcinoma or Endometrial Intraepithelial Neoplasia
Recruiting
To assess the feasibility of an expedited referral process for the obese endometrial cancer or EIN patient from her gynecologic oncologist to the Brigham Center for Metabolic and Bariatric Surgery (CMBS) in order to undergo concurrent weight loss surgery and hysterectomy within 8 weeks of first appointment with a gynecologic oncologist (or 12 weeks for EIN patients).
Gender:
Female
Ages:
18 years and above
Trial Updated:
07/26/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts +1 locations
Conditions: Endometrial Carcinoma, Obesity, EIN, Endometrial Intraepithelial Neoplasia, Endometrial Cancer Stage I
A Phase 1 Trial of ZN-A-1041 Enteric Capsules or Combination in Patients With HER2-Positive Advanced Solid Tumors
Recruiting
This will be a Phase 1, multicenter, open-label trial to evaluate the safety, tolerability, PK and efficacy of ZN-A-1041 as a monotherapy or in combination in patients with HER2-positive advanced solid tumors with or without brain metastases. The study will consist of three phases: Phase 1a (dose escalation with ZN-A-1041 monotherapy), Phase 1b (dose escalation with ZN-A-1041 combination therapy) and Phase 1c (dose expansion with ZN-A-1041 combination therapy).
Gender:
All
Ages:
18 years and above
Trial Updated:
07/26/2023
Locations: Dana-Farber Cancer Insitute, Boston, Massachusetts
Conditions: Advanced Solid Tumors, HER2-positive Breast Cancer
Lipid Management in Renal Transplant Recipients Using Evolocumab.
Recruiting
Cardiovascular disease is the leading cause of mortality after renal transplantation, accounting for more than 30% of deaths. Elevated lipid levels (hyperlipidemia) are a frequent finding following transplantation and the immunosuppressive medications play a central role in the development or worsening of hyperlipidemia. In the general population, the correlation between elevated serum cholesterol and increased risk of cardiovascular disease is well established and the reduction in serum LDL cho... Read More
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
07/25/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Hyperlipidemias
Brief Title: Project 4 Example: Mixed Hybrid Checklist
Recruiting
In "Mixed Hybrid Search", participants look for 3 specific target (e.g. this boot, this cat, this hat) and 3 categorical items (ANY fruit, ANY car, ANY game). In this task, participants tend to miss many categorical items. This is analogous to radiologists missing "incidental findings" when reading medical images. In this experiment, participants were given a checklist to help them to find categorical targets.
Gender:
All
Ages:
18 years and above
Trial Updated:
07/25/2023
Locations: Visual Attention Lab / Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Incidental Findings, Visual Attention, Visual Search, Hybrid Search
Project 3 Example: Human-AI Collaboration Tester (HAICT) Exp. 7
Recruiting
The study is one part of a "bundle" of experiments that constitute Project Three of a National Eye Institute grant. Project Three includes a series of experiments that investigate how changing the input from a simulated AI can affect the decisions made by human observers in a two-alternative forced choice task (like the decision to recall a woman for further examination in mammography). HAICT 7, the experiment described here, investigates how changing prevalence affects human performance when AI... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
07/25/2023
Locations: Visual Attention Lab / Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Decision Making, Computer Aided Diagnosis
Vascularized Composite Allotransplantation for Multiple Extremity Amputations
Recruiting
Limb transplantation surgery is the transfer of one or more limbs from a deceased human donor to a patient with single or multiple limb amputation. Hand transplantation is an innovative reconstructive procedure that has the potential to significantly improve the lives of hand amputees. The purpose of this study is to develop the best practices for multiple limb transplantation that will improve the outcomes of future limb transplant recipients.
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
07/25/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Limb Amputation, Extremity Amputation
Biomarkers for Circadian Timing in Healthy Adults
Recruiting
Study investigators want to learn more about the underlying biological clock and to see if the timing of that clock can be estimated from a single blood sample.
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
07/25/2023
Locations: Brigham & Women's Hospital, Boston, Massachusetts
Conditions: Sleep Wake Disorders, Sleep Disorders, Circadian Rhythm, Sleep Disorders, Intrinsic, Advanced Sleep Phase Syndrome (ASPS), Advanced Sleep Phase Syndrome, Advanced Sleep Phase, Delayed Sleep Phase, Delayed Sleep Phase Syndrome, Non-24 Hour Sleep-Wake Disorder, Irregular Sleep-Wake Syndrome, Shift-Work Sleep Disorder, Shift Work Type Circadian Rhythm Sleep Disorder, Delayed Phase Sleep Syndrome
Safety and Efficacy of Atorvastatin v. Placebo on HCC Risk
Recruiting
Prospective randomized, multi-center, double blind placebo-controlled trial to assess the chemopreventive impact of atorvastatin (20 mg oral) vs placebo in up to 60 adults with advanced fibrosis at high risk of developing HCC.
Gender:
All
Ages:
18 years and above
Trial Updated:
07/25/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Liver Fibroses, Cirrhosis
The Functional Neuroanatomy of the Human Physiological Stress Response
Recruiting
The purpose of this study is to examine the effect of a moderately low blood sugar stress on the nervous system. The investigators hope that information obtained from completing this study will help to reveal information about how a non-psychological stress impacts the parts of the brain that react to stress and the autonomic nervous system. The autonomic nervous system is the part of the nervous system that provides the body with involuntary or automatic control of heart rate, blood pressure, a... Read More
Gender:
All
Ages:
Between 18 years and 45 years
Trial Updated:
07/25/2023
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts +1 locations
Conditions: Hypoglycemia, Physiological Stress
The Effect of Sleep Loss on Emotion Regulation
Recruiting
The study is designed to investigate the impact of three nights of sleep restricted to 4 hours per night, on the processing and regulation of emotional information compared to Insomnia Disorder and control. The investigators will address and attempt to answer two questions. (i) How do three nights of reduced sleep or a diagnosis of Insomnia Disorder affect the processing and regulation of emotional information compared to typical, undisturbed sleep? (ii) What overlapping and distinct neural mec... Read More
Gender:
All
Ages:
Between 18 years and 40 years
Trial Updated:
07/25/2023
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Sleep, Insomnia, Sleep Deprivation
Perinatal Brain Injury: Potential of Innovative NIRS to Optimize Hypothermia
Recruiting
The purpose of this study is to improve the ability of the investigators to monitor brain health in newborn babies at risk of brain injuries. The researchers will be using an investigational system of devices to non-invasively (that, is, without penetrating the skin), measure the amount of oxygen going to and being used by the brain. They will be taking some bedside research measurements during the babies' stay at the hospital. With these measurements, the intention is to study the role of oxyge... Read More
Gender:
All
Ages:
2 years and below
Trial Updated:
07/24/2023
Locations: Boston Children's Hospital, Boston, Massachusetts +2 locations
Conditions: Hypoxic Ischemic Brain Injury, Neonatal Encephalopathy
A Pilot Study on Neuroimaging in SCD: Part of The Boston Consortium to Cure Sickle Cell Disease
Recruiting
Sickle Cell Disease (SCD) impairs oxygen transport to tissue and causes endothelial injury. Thus, therapeutic interventions aim to improve both, but there is an unmet need for biomarkers to determine when intervention is necessary and evaluate the effectiveness of the chosen intervention in individual patients. This study proposes to monitor SCD and its treatment through their impact on cerebral hemodynamics, as the brain is one of the most vulnerable and consequential targets of the disease. Sp... Read More
Gender:
All
Ages:
Between 8 years and 18 years
Trial Updated:
07/24/2023
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Sickle Cell Disease