There are currently 1093 clinical trials in Rochester, Minnesota looking for participants to engage in research studies. Trials are conducted at various facilities, including Mayo Clinic, Mayo Clinic in Rochester, Mayo Clinic - Rochester and Mayo Clinic Cancer Center. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Retifanlimab with Bevacizumab and Hypofractionated Radiotherapy for the Treatment of Recurrent Glioblastoma
NCT06160206
Recruiting
This phase II trial tests how well retifanlimab with bevacizumab and hypofractionated radiotherapy, compared to bevacizumab and hypofractionated radiotherapy alone, works in treating patients with glioblastoma that has come back after a period of improvement (recurrent). A monoclonal antibody is a type of protein that can bind to certain targets in the body, such as molecules that cause the body to make an immune response (antigens). Immunotherapy with monoclonal antibodies, such as retifanlimab... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/14/2024
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Recurrent Glioblastoma, Recurrent WHO Grade 4 Glioma
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Myocardial Mechanisms in Heart Failure With Preserved Ejection Fraction
NCT06517186
Recruiting
The purpose of this study is to identify changes in heart tissue structure and biological function in patients with heart failure by performing an endomyocardial biopsy (EMB or heart biopsy) during a right heart catheterization (RHC). The ultimate goal is to use this information to develop new treatments for heart failure.
Gender:
ALL
Ages:
30 years and above
Trial Updated:
11/14/2024
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Heart Failure, Heart Failure With Preserved Ejection Fraction
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Phase 1/2a Study of Belantamab Mafodotin in Relapsed or Refractory AL Amyloidosis
NCT05145816
Recruiting
The goal of this study is to test the safety of drug, Belantamab Mafodotin, and see what effects (good and bad) it has on people who take it and amyloidosis, and to determine the most effective dose of the drug. The study will have 2 phases (parts). The first phase of the study will test different doses of Belantamab Mafodotin. The second phase will test Belantamab Mafodotin at the dose level found to be safe and effective in phase 1
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/13/2024
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: AL Amyloidosis, Amyloidosis
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A Study of Endoscopic Sleeve Gastroplasty for Obesity in Ulcerative Colitis
NCT05739162
Recruiting
The purpose of this research is to gather information on the safety and effectiveness of Endoscopic Sleeve Gastroplasty (ESG) for weight loss in a population of obese UC patients undergoing colectomy with eventual IPAA.
Gender:
ALL
Ages:
Between 22 years and 69 years
Trial Updated:
11/13/2024
Locations: Mayo Clinic Minnesota, Rochester, Minnesota
Conditions: Obesity, Ulcerative Colitis
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Shared Decision Making for Kidney Transplant Candidates to Plan for an Organ Offer Decision
NCT05879302
Recruiting
The goal of this pilot randomized trial is to learn about shared decision making in kidney transplant candidates. The aim of this proposal is to evaluate the Donor Plan Donor Choice tool to promote high-quality Shared Decision Making for providers and kidney transplant candidates at two transplant centers. Participants will: * Review an online education tool, Donor Plan Donor Choice. * Discuss a Kidney Offer Plan with a transplant provider. * Answer questions about willingness to consider diff... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/13/2024
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: End Stage Renal Disease, End-Stage Kidney Disease, Kidney Transplantation, Esrd
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ADSTILADRIN Early Utilization and Outcomes in the Real World Setting
NCT06026332
Recruiting
Multi-center, prospective non-interventional study to collect data on the early use of Adstiladrin in the US and Israel. Data will be collected from patients and prescribing physicians in a real-world setting
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/12/2024
Locations: Ferring Investigational Site, Rochester, Minnesota
Conditions: Bladder Cancer
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NOX4 and Related Biomarkers in ADPKD
NCT04630613
Recruiting
To determine the value of NOX4, markers of mitochondria injury and function, and oxidative stress as real-time biomarkers to assess disease severity in patients with early autosomal dominant polycystic kidney disease (ADPKD).
Gender:
ALL
Ages:
Between 15 years and 40 years
Trial Updated:
11/08/2024
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Autosomal Dominant Polycystic Kidney Disease
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Longitudinal Multi-Modality Imaging in Progressive Apraxia of Speech
NCT01818661
Recruiting
The study is designed to determine the relationship between structural and functional changes in the brain on imaging and progression of speech and language, neurological and neuropsychological features in patients with neurodegenerative apraxia of speech (AOS).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/07/2024
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: PPA, Non-fluent Aphasia, Apraxia of Speech, Primary Progressive Non-fluent Aphasia, Primary Progressive Aphasia
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A Molecular Anatomic Imaging Analysis of Tau in Progressive Supranuclear Palsy
NCT02605785
Recruiting
This study is designed to learn more about overall tau burden in the brain of patients with Progressive Supranuclear Palsy (PSP).
Gender:
ALL
Ages:
35 years and above
Trial Updated:
11/07/2024
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Progressive Supranuclear Palsy
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Clinical and Basic Investigations Into Congenital Disorders of Glycosylation
NCT04199000
Recruiting
The purpose of this research is to study the natural history of congenital disorders of glycosylation and its causes and treatments.
Gender:
ALL
Ages:
All
Trial Updated:
11/07/2024
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Congenital Disorders of Glycosylation
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Study of Tadalafil Vs. Placebo for Improving Hemodynamics and End-Organ Dysfunction in Fontan Physiology
NCT05206955
Recruiting
The purpose of this study is to find out more about the effectiveness of Tadalafil in improving hemodynamic capabilities, endothelial function, and end-organ function in patients who have previously undergone a Fontan Palliation.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/07/2024
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Fontan Palliation
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North American Prodromal Synucleinopathy Consortium Stage 2
NCT05826457
Recruiting
This study will enroll participants with idiopathic REM sleep behavior disorder (RBD) and healthy controls for the purpose of preparing for a clinical trial of neuroprotective treatments against synucleinopathies.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/04/2024
Locations: Mayo Clinic Rochester, Rochester, Minnesota
Conditions: REM Sleep Behavior Disorder, Parkinson Disease, Lewy Body Dementia, Dementia With Lewy Bodies, Multiple System Atrophy, REM Sleep Parasomnias
Register for Updates