There are currently 1093 clinical trials in Rochester, Minnesota looking for participants to engage in research studies. Trials are conducted at various facilities, including Mayo Clinic, Mayo Clinic in Rochester, Mayo Clinic - Rochester and Mayo Clinic Cancer Center. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Depemokimab in Participants With Hypereosinophilic Syndrome, Efficacy, and Safety Trial
NCT05334368
Recruiting
This is a 52-week, randomized, placebo-controlled, double-blind, parallel group, multicenter study of depemokimab in adults with uncontrolled HES receiving standard of care (SoC) therapy. The study will recruit patients with a confirmed diagnosis of HES and who are on stable HES therapy for at least 4 weeks prior to randomization (Visit 2). Eligible participants must have uncontrolled HES with a history of repeated flare (≥2 flares in the previous 12 months) and blood eosinophil count of ≥1,000... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
09/06/2023
Locations: GSK Investigational Site, Rochester, Minnesota
Conditions: Hypereosinophilic Syndrome
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Abatacept in Immune Checkpoint Inhibitor Myocarditis
NCT05335928
Recruiting
The primary aim is to test whether abatacept, as compared to placebo, is associated with a reduction in major adverse cardiac events (MACE) among participants hospitalized with myocarditis secondary to an immune checkpoint inhibitor (ICI). The primary outcome, MACE, is a composite of first occurrence of cardiovascular death, non-fatal sudden cardiac arrest, cardiogenic shock, significant ventricular arrythmias, significant bradyarrythmias, or incident heart failure.
Gender:
All
Ages:
18 years and above
Trial Updated:
09/06/2023
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Myocarditis Acute, Cancer
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Post-Intensive Care Syndrome - Pediatrics (PICS-p): Longitudinal Cohort Study
NCT04967365
Recruiting
Pediatric Intensive Care Unit (PICU) survival has increased substantially over the past three decades. Currently, an understanding of PICU morbidity and recovery among PICU survivors and their families is limited. Post-intensive care syndrome (PICS) consists of new or worsening impairments in physical, cognitive, or mental health status that arise and may persist after critical illness. The characteristics of PICS in children (PICS-p) are unknown. The objective of this study is to learn about pe... Read More
Gender:
All
Ages:
Between 1 month and 16 years
Trial Updated:
09/06/2023
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Critical Illness, Post Intensive Care Unit Syndrome
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Early Feasibility Study - Transcatheter Atrial Shunt System
NCT03523416
Recruiting
The purpose of this study is to evaluate initial clinical safety, device functionality and effectiveness of the Edwards Transcatheter Atrial Shunt System.
Gender:
All
Ages:
18 years and above
Trial Updated:
09/05/2023
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Heart Failure
Register for Updates
Nonlinear Elasticity Mapping of Breast Masses
NCT04863443
Recruiting
This proposed technique, called "Nonlinear Elasticity Mapping (NEM)", is an innovative approach to estimate (i.e., linear and nonlinear) elasticity to provide complementary and relevant information for identification and characterization of breast masses. The proposed technique includes imaging the (nonlinear) elasticity parameter in a quantitative manner and measuring two new and relevant parameters. These parameters, together with linear elasticity, are used to differentiate breast masses. Th... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
09/05/2023
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Breast Cancer
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Mucosal and Microbiota Changes During Acute Campylobacteriosis
NCT03223077
Recruiting
Gastrointestinal (GI) infection with Campylobacter causes inflammation in the bowel and can change bacteria in the gut. Certain individuals with Campylobacter infection are also known to develop chronic bowel problems such as Irritable Bowel Syndrome (IBS). The researchers are doing this study to understand if changes in gut bacteria and gut mucosal lining during an acute infection can help identify individuals who might be at risk for developing problems in the future.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
09/05/2023
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Irritable Bowel Syndrome
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Safety Study of OA-235i in Subjects With Nonalcoholic Steatohepatitis
NCT05680233
Recruiting
This study is a Phase 1, first-in-human single-dose escalation study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of OA-235i in subjects with nonalcoholic steatohepatitis.
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
09/05/2023
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Nonalcoholic Steatohepatitis, Nonalcoholic Fatty Liver
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OMEGA: Outcome Measures in Eosinophilic Gastrointestinal Disorders Across the Ages
NCT02523118
Recruiting
The purpose of this observational study is to find the best measures to define how well a person with eosinophilic disorder is doing. People with EoE, EG, EGE and EC normally undergo endoscopy and/or colonoscopy where cells are collected for microscopic analysis. Treatments are then decided based on how the cells look. We are aiming to compare different tissue components such as inflammatory cell types with clinical symptoms. We want to see if scores on standard questionnaires can give us an ide... Read More
Gender:
All
Ages:
3 years and above
Trial Updated:
09/01/2023
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Eosinophilic Gastrointestinal Disorders (EGIDs), Eosinophilic Esophagitis, Eosinophilic Colitis, Eosinophilic Gastritis, Eosinophilic Gastroenteritis
Register for Updates
Personalized Therapy Study - Intrinsic Antitachycardia Pacing Post-Approval Study (iATP PAS)
NCT04496518
Recruiting
Medtronic is sponsoring the Intrinsic Antitachycardia Pacing Post-Approval Study (iATP PAS) to further confirm safety and effectiveness of ventricular iATP therapy in routine clinical practice, following commercial release of iATP-capable devices. The iATP PAS is conducted within Medtronic's Product Surveillance Registry platform (NCT01524276).
Gender:
All
Ages:
All
Trial Updated:
08/29/2023
Locations: Mayo Clinic (Rochester MN), Rochester, Minnesota
Conditions: Ventricular Tachycardia
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A Clinical Registry of Spontaneous Intracranial Hypotension
NCT05922514
Recruiting
The purpose of this research is to determine the efficacy of paraspinal vein embolization for treatment of digital subtraction myelography (DSM) or CT myelography (CTM) confirmed cerebrospinal fluid (CSF)-venous fistulas so that researchers can inform the development and design of future clinical trials of this technique.
Gender:
All
Ages:
18 years and above
Trial Updated:
08/29/2023
Locations: Mayo Clinic Minnesota, Rochester, Minnesota
Conditions: Spontaneous Intracranial Hypotension
Register for Updates
Ommaya Reservoir Placement for Brain Tumor Biomarker Access
NCT04692337
Recruiting
The purpose of this study is to determine the safety and feasibility of intra-operative Ommaya Reservoir placement during a clinically indicated operation for brain tumor. The Ommaya reservoir will facilitate a longitudinal access to cerebrospinal fluid (CSF) for analysis of potential biomarkers for brain tumor research and individualized monitoring.
Gender:
All
Ages:
18 years and above
Trial Updated:
08/29/2023
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Brain Tumor
Register for Updates
Personalized Therapy Study - HFRS (TriageHF) Post Approval Study
NCT04489225
Recruiting
Medtronic is sponsoring the HFRS PAS to evaluate the HFRS feature (TriageHF) when used in routine clinical practice following commercial release. The HFRS PAS is conducted within Medtronic's Product Surveillance Registry (PSR) platform.
Gender:
All
Ages:
All
Trial Updated:
08/29/2023
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Heart Failure
Register for Updates