There are currently 1093 clinical trials in Rochester, Minnesota looking for participants to engage in research studies. Trials are conducted at various facilities, including Mayo Clinic, Mayo Clinic in Rochester, Mayo Clinic - Rochester and Mayo Clinic Cancer Center. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
A Study of Voruciclib Alone or in Combination With Venetoclax in Subjects With B-Cell Malignancies or AML
NCT03547115
Recruiting
This is a Phase 1, open-label, dose escalation study to determine the safety and preliminary efficacy of voruciclib monotherapy in subjects with relapsed/refractory B cell malignancies or AML after failure of standard therapies or voruciclib in combination with venetoclax in subjects with relapsed or refractory AML
Gender:
All
Ages:
18 years and above
Trial Updated:
08/03/2023
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Follicular Lymphoma (FL), Mantle Cell Lymphoma (MCL), Marginal Zone Lymphoma (MZL), Small Lymphocytic Lymphoma (SLL), Chronic Lymphocytic Leukemia (CLL), Diffuse Large B-cell Lymphoma (DLBCL), Acute Myeloid Leukemia (AML)
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HELP-HY: Health Education and sLeep Program in HYpertension
NCT03255746
Recruiting
Hypertension is the major risk factor for cardiovascular and cerebrovascular diseases worldwide. The escalating prevalence of inadequate sleep now parallels that of hypertension. Observational and experimental evidence favoring a causal relation between insufficient sleep and hypertension are particularly compelling - sleeping 6 hours or less per night is associated with a 20-32% higher probability of incident hypertension. Since sleep curtailment is largely voluntary, sleep deficiency may be co... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
08/02/2023
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Prehypertension, Hypertension
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Catheter Ablation of Ventricular Arrhythmia Reduces Skin Sympathetic Activity
NCT04837183
Recruiting
This study is being done to determine whether there is an increase in sympathetic nerve activity before the onset of ventricular arrhythmias or irregular heartbeat rhythm. In addition, this study is looking at the relationship between sympathetic nerve activity and how patients with ventricular arrhythmias respond to catheter ablation treatment.
Gender:
All
Ages:
18 years and above
Trial Updated:
08/01/2023
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Ventricular Tachycardia
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Genetic Markers of Cardiovascular Disease in Epilepsy
NCT02824822
Recruiting
Epilepsy is a common condition which affects over 3 million people in the US. Patients with uncontrolled epilepsy have a lifetime risk of sudden unexpected death (SUDEP) of 35%, which is greatest in those under 40 years of age. The exact mechanisms and causes are not understood but can be due to underlying conditions which affect the heart and brain, which may lead to dangerous heart rhythms and death. Some of these conditions which affect heart and brain have an identifiable genetic cause. This... Read More
Gender:
All
Ages:
Between 18 years and 50 years
Trial Updated:
08/01/2023
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Epilepsy, Seizures, Syncope, Channelopathy, Cardiomyopathies
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Prospective Sinonasal Cancer Multi-institution Study
NCT04755855
Recruiting
This is a multi-institution prospective study of patients with sinonasal malignancies. The goal of this study is to learn more about the course of sinonasal cancer, treatment outcomes, and patient quality of life. In addition, central mutational and genomic analysis of tumor tissue will be evaluated.
Gender:
All
Ages:
Between 30 days and 99 years
Trial Updated:
08/01/2023
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Sinonasal Carcinoma
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Study of RP1 Monotherapy and RP1 in Combination With Nivolumab
NCT03767348
Recruiting
RPL-001-16 is a Phase 1/2, open label, dose escalation and expansion clinical study of RP1 alone and in combination with nivolumab in adult subjects with advanced and/or refractory solid tumors, to determine the maximum tolerated dose (MTD) and recommended Phase 2 dose (RP2D), as well as to evaluate preliminary efficacy.
Gender:
All
Ages:
18 years and above
Trial Updated:
08/01/2023
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Cancer, Melanoma (Skin), Mismatch Repair Deficiency, Microsatellite Instability, Non-melanoma Skin Cancer, Cutaneous Melanoma, NSCLC
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Prevalence of Transthyretin Cardiac Amyloidosis in Clinically Significant Aortic Stenosis
NCT04899180
Recruiting
The purpose of this study is to determine the prevalence of transthyretin cardiac amyloidosis (TTR-CA) among patients with moderate and severe aortic stenosis in Southeast Minnesota using 99mTc-PYP single-photon positive emission computed tomography with computed tomography (SPECT/CT).
Gender:
All
Ages:
75 years and above
Trial Updated:
07/31/2023
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Aortic Stenosis, Transthyretin Amyloidosis, Transthyretin Amyloid Cardiomyopathy, Transthyretin Cardiac Amyloidosis
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Predicting Progression of Developing Myeloma in a High-Risk Screened Population (PROMISE)
NCT03689595
Recruiting
The PROMISE Study aims to establish a prospective cohort of individuals with precursor conditions to multiple myeloma, such as monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM). We will study these patients as a means to identify risk factors for progression to symptomatic multiple myeloma.
Gender:
All
Ages:
30 years and above
Trial Updated:
07/30/2023
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Multiple Myeloma
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Determining How Indoor Lighting Affects the Brain Health of Older Adults
NCT05978934
Recruiting
The goal of this randomized, cross-over, single-site trial followed by an exploratory third intervention is to understand how indoor lighting affects different measures of brain health in older adults living in independent living residences. This is a community based study occurring in a local senior living facility. The main question this study aims to answer is: - How does the quality of ambient indoor lighting an older adult is exposed to affect measures of brain health, such as sleep qualit... Read More
Gender:
All
Ages:
60 years and above
Trial Updated:
07/28/2023
Locations: The Waters on Mayowood, Rochester, Minnesota
Conditions: Sleep, Physical Activity, Cognitive Function, Social Isolation
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AIM1: Adequate Selection of Patients for Thyroid Biopsy: Evaluation of a Shared Decision Making Conversation Aid
NCT04472026
Recruiting
There is an epidemic of thyroid cancer that is harmful to patients and the medical system. The study hypothesizes that the use of an electronic conversation aid during clinical visits can help patients and clinicians collaborate when deciding the next step in management for a thyroid nodule. The study aims to update a conversation aid prototype that was developed to support shared decision making in the diagnosis of thyroid cancer.
Gender:
All
Ages:
Between 18 years and 99 years
Trial Updated:
07/26/2023
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Thyroid Nodules, Thyroid Cancer
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Trial of Parkinson's And Zoledronic Acid
NCT03924414
Recruiting
This home-based study is a randomized (1:1) placebo-controlled trial of a single infusion of zoledronic acid-5 mg (ZA) for the prevention of fractures in men and women aged 60 years and older with Parkinson's disease and parkinsonism with at least 2 years of follow-up. A total of 3500 participants will be enrolled and randomized in the United States. Participants, follow-up outcome assessors, and study investigators will be blinded to assigned study treatment. This trial is funded by the Nationa... Read More
Gender:
All
Ages:
60 years and above
Trial Updated:
07/24/2023
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Parkinson Disease, Osteoporosis, Parkinsonism, Parkinson's Disease and Parkinsonism, Atypical Parkinsonism, Progressive Supranuclear Palsy, Multiple System Atrophy, Vascular Parkinsonism, Dementia With Lewy Bodies
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A Study to Evaluate Breathing Muscle Training in Cardiac Rehab
NCT04984473
Recruiting
The purpose of this study is to understand if breathing muscle training combined with cardiac rehabilitation influences the blood flow and blood pressure response during exercise.
Gender:
All
Ages:
18 years and above
Trial Updated:
07/24/2023
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Healthy, Heart Failure
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